dimethyltubocurarinium ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
quaternary ammonium compounds 908 5152-30-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • trimethyltubocurarine iodide
  • metocurine iodide
  • dimethyltubocurarine
  • metocurine
  • dimethyltubocurarinium
  • dimethyltubocurarinium chloride
from Chinese herb Cyclea hainanensis Mrr
  • Molecular weight: 652.83
  • Formula: C40H48N2O6
  • CLOGP: 0.52
  • LIPINSKI: 1
  • HAC: 8
  • HDO: 0
  • TPSA: 55.38
  • ALOGS: -8.05
  • ROTB: 4

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 3 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.33 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.20 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.65 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
None FDA LILLY

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M03AA04 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS
Curare alkaloids
MeSH PA D009465 Neuromuscular Agents
MeSH PA D009466 Neuromuscular Blocking Agents
MeSH PA D003473 Neuromuscular Nondepolarizing Agents
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Muscle relaxation, function indication 11977004




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Acetylcholine receptor Ion channel ANTAGONIST IC50 7.75 WOMBAT-PK CHEMBL
Neuronal acetylcholine receptor; alpha2/beta2 Ion channel WOMBAT-PK

External reference:

IDSource
4017449 VUID
N0000145837 NUI
D00761 KEGG_DRUG
7601-55-0 SECONDARY_CAS_RN
35-67-6 SECONDARY_CAS_RN
203206 RXNORM
4017449 VANDF
CHEBI:6900 CHEBI
CU9 PDB_CHEM_ID
CHEMBL1259 ChEMBL_ID
CHEMBL1739 ChEMBL_ID
CHEMBL2105841 ChEMBL_ID
C032943 MESH_SUPPLEMENTAL_RECORD_UI
C015836 MESH_SUPPLEMENTAL_RECORD_UI
DB00416 DRUGBANK_ID
DB01336 DRUGBANK_ID
5100 MMSL
d00950 MMSL
002401 NDDF
004814 NDDF
1325004 SNOMEDCT_US
373781002 SNOMEDCT_US
89664002 SNOMEDCT_US
C0700566 UMLSCUI
21233 PUBCHEM_CID
O0U0E87X7F UNII

Pharmaceutical products:

None