| Stem definition | Drug id | CAS RN |
|---|---|---|
| N-methylated xanthine derivatives | 901 | 523-87-5 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
A drug combination that contains diphenhydramine and theophylline. It is used for treating VERTIGO, MOTION SICKNESS, and NAUSEA associated with PREGNANCY.
|
| Dose | Unit | Route |
|---|---|---|
| 0.30 | g | O |
| 0.30 | g | R |
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| May 31, 1972 | FDA | ALRA |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Urine abnormality | 431.77 | 14.80 | 168 | 43954 | 6851 | 63438049 |
| Lymphocyte count decreased | 334.57 | 14.80 | 227 | 43895 | 30030 | 63414870 |
| Urine leukocyte esterase positive | 275.70 | 14.80 | 101 | 44021 | 3478 | 63441422 |
| White blood cells urine positive | 210.23 | 14.80 | 92 | 44030 | 5066 | 63439834 |
| Red blood cells urine positive | 207.13 | 14.80 | 79 | 44043 | 3047 | 63441853 |
| Blood urine present | 205.56 | 14.80 | 129 | 43993 | 14940 | 63429960 |
| Enthesopathy | 199.01 | 14.80 | 104 | 44018 | 8510 | 63436390 |
| Tongue disorder | 181.65 | 14.80 | 105 | 44017 | 10475 | 63434425 |
| Urinary sediment present | 180.23 | 14.80 | 65 | 44057 | 2138 | 63442762 |
| Tenosynovitis | 170.56 | 14.80 | 111 | 44011 | 13684 | 63431216 |
| Blood parathyroid hormone decreased | 162.34 | 14.80 | 95 | 44027 | 9696 | 63435204 |
| Aplastic anaemia | 159.07 | 14.80 | 93 | 44029 | 9476 | 63435424 |
| Urine ketone body present | 150.69 | 14.80 | 59 | 44063 | 2444 | 63442456 |
| Chest discomfort | 150.17 | 14.80 | 272 | 43850 | 109697 | 63335203 |
| Panniculitis | 149.12 | 14.80 | 95 | 44027 | 11290 | 63433610 |
| Flushing | 143.32 | 14.80 | 216 | 43906 | 74871 | 63370029 |
| Red blood cell sedimentation rate | 142.68 | 14.80 | 69 | 44053 | 4785 | 63440115 |
| Granuloma skin | 137.61 | 14.80 | 81 | 44041 | 8356 | 63436544 |
| Urine analysis abnormal | 137.55 | 14.80 | 68 | 44054 | 4948 | 63439952 |
| Skin necrosis | 136.19 | 14.80 | 97 | 44025 | 13853 | 63431047 |
| Rheumatoid nodule | 122.57 | 14.80 | 99 | 44023 | 17056 | 63427844 |
| Death | 121.75 | 14.80 | 54 | 44068 | 374327 | 63070573 |
| Crystal urine present | 121.20 | 14.80 | 45 | 44077 | 1609 | 63443291 |
| Red cell distribution width increased | 109.28 | 14.80 | 76 | 44046 | 10448 | 63434452 |
| Haemoglobin urine present | 105.48 | 14.80 | 34 | 44088 | 789 | 63444111 |
| Tendonitis | 105.10 | 14.80 | 96 | 44026 | 19519 | 63425381 |
| Ulcer | 104.68 | 14.80 | 109 | 44013 | 25998 | 63418902 |
| Culture urine positive | 104.13 | 14.80 | 51 | 44071 | 3636 | 63441264 |
| Alanine aminotransferase abnormal | 102.95 | 14.80 | 54 | 44068 | 4450 | 63440450 |
| Neovascularisation | 102.04 | 14.80 | 36 | 44086 | 1109 | 63443791 |
| Bacterial test positive | 100.05 | 14.80 | 56 | 44066 | 5251 | 63439649 |
| Febrile neutropenia | 96.21 | 14.80 | 237 | 43885 | 118212 | 63326688 |
| Fear of injection | 86.97 | 14.80 | 57 | 44065 | 7107 | 63437793 |
| Specific gravity urine decreased | 86.89 | 14.80 | 29 | 44093 | 753 | 63444147 |
| Lymphocyte percentage decreased | 86.43 | 14.80 | 42 | 44080 | 2943 | 63441957 |
| Arterial occlusive disease | 86.29 | 14.80 | 53 | 44069 | 5905 | 63438995 |
| Gastric disorder | 85.18 | 14.80 | 117 | 44005 | 37252 | 63407648 |
| Gangrene | 84.96 | 14.80 | 53 | 44069 | 6070 | 63438830 |
| Oesophageal spasm | 84.63 | 14.80 | 42 | 44080 | 3081 | 63441819 |
| Hypercalcaemia | 83.93 | 14.80 | 101 | 44021 | 28221 | 63416679 |
| Bacterial test | 82.59 | 14.80 | 31 | 44091 | 1143 | 63443757 |
| Hand deformity | 81.91 | 14.80 | 8 | 44114 | 159449 | 63285451 |
| Nausea | 80.06 | 14.80 | 925 | 43197 | 853546 | 62591354 |
| Basal cell carcinoma | 78.37 | 14.80 | 97 | 44025 | 27894 | 63417006 |
| Eosinophil count increased | 75.81 | 14.80 | 62 | 44060 | 10866 | 63434034 |
| Neutrophil percentage increased | 75.10 | 14.80 | 38 | 44084 | 2905 | 63441995 |
| Wound | 74.62 | 14.80 | 12 | 44110 | 163251 | 63281649 |
| Feeling hot | 74.39 | 14.80 | 129 | 43993 | 50225 | 63394675 |
| Drug ineffective | 72.88 | 14.80 | 428 | 43694 | 1044337 | 62400563 |
| Eosinophil percentage increased | 71.76 | 14.80 | 27 | 44095 | 1002 | 63443898 |
| Drug eruption | 71.75 | 14.80 | 94 | 44028 | 28600 | 63416300 |
| Oesophageal pain | 69.62 | 14.80 | 39 | 44083 | 3662 | 63441238 |
| Body temperature increased | 69.51 | 14.80 | 106 | 44016 | 37086 | 63407814 |
| Swelling | 68.01 | 14.80 | 55 | 44067 | 275323 | 63169577 |
| Monocyte percentage increased | 65.39 | 14.80 | 26 | 44096 | 1122 | 63443778 |
| Heart sounds | 65.37 | 14.80 | 25 | 44097 | 971 | 63443929 |
| Blood creatinine decreased | 64.60 | 14.80 | 43 | 44079 | 5502 | 63439398 |
| Alveolitis | 63.93 | 14.80 | 34 | 44088 | 2881 | 63442019 |
| Prolonged expiration | 63.05 | 14.80 | 25 | 44097 | 1071 | 63443829 |
| Rash pruritic | 62.21 | 14.80 | 132 | 43990 | 59667 | 63385233 |
| Infusion site pain | 61.55 | 14.80 | 67 | 44055 | 16802 | 63428098 |
| Urticaria | 60.64 | 14.80 | 252 | 43870 | 165550 | 63279350 |
| Oropharyngeal pain | 60.39 | 14.80 | 173 | 43949 | 94314 | 63350586 |
| Paradoxical drug reaction | 60.29 | 14.80 | 37 | 44085 | 4115 | 63440785 |
| Mean cell haemoglobin concentration increased | 60.23 | 14.80 | 20 | 44102 | 511 | 63444389 |
| C-reactive protein abnormal | 57.81 | 14.80 | 110 | 44012 | 45986 | 63398914 |
| Completed suicide | 57.68 | 14.80 | 15 | 44107 | 145658 | 63299242 |
| Toxicity to various agents | 56.65 | 14.80 | 53 | 44069 | 247197 | 63197703 |
| Insomnia | 56.53 | 14.80 | 297 | 43825 | 214955 | 63229945 |
| Poor venous access | 56.18 | 14.80 | 60 | 44062 | 14725 | 63430175 |
| Monocyte count decreased | 55.52 | 14.80 | 28 | 44094 | 2125 | 63442775 |
| Headache | 55.32 | 14.80 | 677 | 43445 | 632564 | 62812336 |
| Heart rate increased | 54.00 | 14.80 | 166 | 43956 | 94072 | 63350828 |
| Myocardial reperfusion injury | 53.39 | 14.80 | 13 | 44109 | 101 | 63444799 |
| Blood thyroid stimulating hormone increased | 52.41 | 14.80 | 42 | 44080 | 7152 | 63437748 |
| Angina pectoris | 52.40 | 14.80 | 83 | 44039 | 29995 | 63414905 |
| Blood uric acid decreased | 52.19 | 14.80 | 20 | 44102 | 781 | 63444119 |
| Hyponatraemia | 51.63 | 14.80 | 8 | 44114 | 111892 | 63333008 |
| Granuloma | 51.53 | 14.80 | 38 | 44084 | 5723 | 63439177 |
| Blood pressure fluctuation | 51.40 | 14.80 | 105 | 44017 | 46212 | 63398688 |
| Pericarditis | 51.24 | 14.80 | 14 | 44108 | 131565 | 63313335 |
| Stress | 50.94 | 14.80 | 131 | 43991 | 67036 | 63377864 |
| Skin ulcer | 50.65 | 14.80 | 100 | 44022 | 42945 | 63401955 |
| Alanine aminotransferase increased | 50.61 | 14.80 | 173 | 43949 | 103597 | 63341303 |
| Impaired healing | 50.46 | 14.80 | 6 | 44116 | 102536 | 63342364 |
| Drug interaction | 50.30 | 14.80 | 51 | 44071 | 229080 | 63215820 |
| Loss of personal independence in daily activities | 49.93 | 14.80 | 165 | 43957 | 97125 | 63347775 |
| Intestinal pseudo-obstruction | 49.67 | 14.80 | 20 | 44102 | 892 | 63444008 |
| Erythema | 49.26 | 14.80 | 247 | 43875 | 175504 | 63269396 |
| Rhinorrhoea | 46.77 | 14.80 | 125 | 43997 | 65452 | 63379448 |
| Nitrite urine present | 46.66 | 14.80 | 20 | 44102 | 1046 | 63443854 |
| Haematocrit decreased | 45.82 | 14.80 | 91 | 44031 | 39249 | 63405651 |
| Rheumatoid lung | 45.21 | 14.80 | 30 | 44092 | 3818 | 63441082 |
| Protein urine present | 45.16 | 14.80 | 36 | 44086 | 6084 | 63438816 |
| Acute kidney injury | 44.96 | 14.80 | 71 | 44051 | 263344 | 63181556 |
| Cough | 43.04 | 14.80 | 349 | 43773 | 292394 | 63152506 |
| Neutrophil count increased | 42.65 | 14.80 | 55 | 44067 | 16472 | 63428428 |
| Red cell distribution width decreased | 42.25 | 14.80 | 23 | 44099 | 2042 | 63442858 |
| Bradycardia | 41.95 | 14.80 | 129 | 43993 | 73098 | 63371802 |
| Arteriovenous fistula occlusion | 41.89 | 14.80 | 14 | 44108 | 365 | 63444535 |
| Oedema peripheral | 41.79 | 14.80 | 42 | 44080 | 189469 | 63255431 |
| Creatinine urine decreased | 41.64 | 14.80 | 12 | 44110 | 188 | 63444712 |
| Blood pressure increased | 41.41 | 14.80 | 222 | 43900 | 161840 | 63283060 |
| Drug tolerance | 41.16 | 14.80 | 36 | 44086 | 6913 | 63437987 |
| Heart rate decreased | 41.09 | 14.80 | 95 | 44027 | 45465 | 63399435 |
| pH urine increased | 41.08 | 14.80 | 14 | 44108 | 388 | 63444512 |
| Body temperature decreased | 40.95 | 14.80 | 60 | 44062 | 20259 | 63424641 |
| Blue toe syndrome | 40.91 | 14.80 | 14 | 44108 | 393 | 63444507 |
| Alopecia | 39.95 | 14.80 | 112 | 44010 | 337424 | 63107476 |
| Cardiac failure congestive | 39.61 | 14.80 | 8 | 44114 | 92425 | 63352475 |
| Urine leukocyte esterase | 39.52 | 14.80 | 11 | 44111 | 151 | 63444749 |
| Neurologic neglect syndrome | 38.88 | 14.80 | 24 | 44098 | 2697 | 63442203 |
| Injection site pain | 38.65 | 14.80 | 21 | 44101 | 129779 | 63315121 |
| Carotid artery thrombosis | 38.30 | 14.80 | 24 | 44098 | 2770 | 63442130 |
| Leukocyturia | 37.82 | 14.80 | 19 | 44103 | 1430 | 63443470 |
| CFTR gene mutation | 37.47 | 14.80 | 10 | 44112 | 116 | 63444784 |
| Cystitis | 37.39 | 14.80 | 103 | 44019 | 54888 | 63390012 |
| Lymphoedema | 36.79 | 14.80 | 43 | 44079 | 11649 | 63433251 |
| Red blood cell sedimentation rate increased | 36.72 | 14.80 | 89 | 44033 | 43893 | 63401007 |
| Depressive symptom | 36.56 | 14.80 | 27 | 44095 | 4075 | 63440825 |
| Product dose omission issue | 36.44 | 14.80 | 67 | 44055 | 234246 | 63210654 |
| Red blood cells urine | 36.43 | 14.80 | 14 | 44108 | 551 | 63444349 |
| Urinary retention | 36.38 | 14.80 | 71 | 44051 | 30230 | 63414670 |
| Thrombocytopenia | 36.28 | 14.80 | 31 | 44091 | 151126 | 63293774 |
| Specific gravity urine increased | 36.19 | 14.80 | 11 | 44111 | 209 | 63444691 |
| Blood thyroid stimulating hormone decreased | 36.02 | 14.80 | 28 | 44094 | 4562 | 63440338 |
| Red blood cell count increased | 35.93 | 14.80 | 24 | 44098 | 3088 | 63441812 |
| Arthropathy | 35.75 | 14.80 | 68 | 44054 | 234724 | 63210176 |
| Influenza | 35.68 | 14.80 | 160 | 43962 | 108562 | 63336338 |
| Joint injury | 35.15 | 14.80 | 69 | 44053 | 29503 | 63415397 |
| Mean cell haemoglobin decreased | 35.12 | 14.80 | 29 | 44093 | 5150 | 63439750 |
| Anaemia | 34.98 | 14.80 | 97 | 44025 | 293333 | 63151567 |
| Blood cholesterol increased | 34.78 | 14.80 | 11 | 44111 | 94021 | 63350879 |
| Red blood cell count decreased | 34.74 | 14.80 | 83 | 44039 | 40562 | 63404338 |
| Migraine | 34.60 | 14.80 | 153 | 43969 | 103193 | 63341707 |
| Myelocyte count increased | 34.38 | 14.80 | 12 | 44110 | 358 | 63444542 |
| Chills | 34.36 | 14.80 | 163 | 43959 | 113215 | 63331685 |
| Multiple sclerosis relapse | 34.15 | 14.80 | 92 | 44030 | 48386 | 63396514 |
| Vascular malformation | 34.06 | 14.80 | 12 | 44110 | 368 | 63444532 |
| Brain death | 33.94 | 14.80 | 24 | 44098 | 3386 | 63441514 |
| Respiratory tract congestion | 33.56 | 14.80 | 51 | 44071 | 17781 | 63427119 |
| Thyroxine free increased | 33.55 | 14.80 | 15 | 44107 | 869 | 63444031 |
| Paranasal cyst | 33.26 | 14.80 | 12 | 44110 | 395 | 63444505 |
| C-reactive protein increased | 33.07 | 14.80 | 142 | 43980 | 94565 | 63350335 |
| Confusional state | 32.98 | 14.80 | 72 | 44050 | 236308 | 63208592 |
| Neuropathy peripheral | 32.96 | 14.80 | 19 | 44103 | 113648 | 63331252 |
| Blood pressure systolic increased | 32.44 | 14.80 | 89 | 44033 | 47308 | 63397592 |
| Mean cell haemoglobin increased | 32.31 | 14.80 | 22 | 44100 | 2921 | 63441979 |
| Tri-iodothyronine free decreased | 32.00 | 14.80 | 11 | 44111 | 313 | 63444587 |
| Respiration abnormal | 31.65 | 14.80 | 30 | 44092 | 6387 | 63438513 |
| Irritable bowel syndrome | 31.64 | 14.80 | 9 | 44113 | 82403 | 63362497 |
| Tachycardia | 31.64 | 14.80 | 164 | 43958 | 117992 | 63326908 |
| Drug tolerance decreased | 31.52 | 14.80 | 49 | 44073 | 17424 | 63427476 |
| Gastrointestinal disorder | 31.39 | 14.80 | 27 | 44095 | 131212 | 63313688 |
| Adjustment disorder | 30.78 | 14.80 | 22 | 44100 | 3156 | 63441744 |
| Band neutrophil percentage increased | 30.78 | 14.80 | 10 | 44112 | 238 | 63444662 |
| Blister | 30.69 | 14.80 | 27 | 44095 | 129787 | 63315113 |
| Band sensation | 30.55 | 14.80 | 14 | 44108 | 859 | 63444041 |
| Aspartate aminotransferase increased | 30.48 | 14.80 | 134 | 43988 | 90143 | 63354757 |
| Urine oxalate increased | 30.24 | 14.80 | 10 | 44112 | 252 | 63444648 |
| Throat irritation | 30.18 | 14.80 | 75 | 44047 | 37572 | 63407328 |
| Heart rate irregular | 29.97 | 14.80 | 55 | 44067 | 22366 | 63422534 |
| Drug abuse | 29.60 | 14.80 | 7 | 44115 | 72511 | 63372389 |
| Crystalluria | 29.14 | 14.80 | 11 | 44111 | 412 | 63444488 |
| Inappropriate schedule of product administration | 29.02 | 14.80 | 146 | 43976 | 103819 | 63341081 |
| Osteoarthritis | 29.01 | 14.80 | 15 | 44107 | 95328 | 63349572 |
| Cardiac failure | 28.68 | 14.80 | 13 | 44109 | 89129 | 63355771 |
| Affect lability | 28.60 | 14.80 | 37 | 44085 | 11114 | 63433786 |
| Mean cell haemoglobin concentration decreased | 28.27 | 14.80 | 22 | 44100 | 3590 | 63441310 |
| Mastoiditis | 28.03 | 14.80 | 14 | 44108 | 1041 | 63443859 |
| Bulimia nervosa | 27.92 | 14.80 | 11 | 44111 | 463 | 63444437 |
| Transfusion | 27.90 | 14.80 | 43 | 44079 | 15174 | 63429726 |
| Disease progression | 27.29 | 14.80 | 27 | 44095 | 122731 | 63322169 |
| Renal failure | 27.18 | 14.80 | 25 | 44097 | 117627 | 63327273 |
| Infection | 27.12 | 14.80 | 76 | 44046 | 229097 | 63215803 |
| Hyperkalaemia | 27.09 | 14.80 | 3 | 44119 | 54200 | 63390700 |
| Feeling abnormal | 26.91 | 14.80 | 186 | 43936 | 148206 | 63296694 |
| Appetite disorder | 26.57 | 14.80 | 29 | 44093 | 7292 | 63437608 |
| Osteomyelitis | 26.54 | 14.80 | 57 | 44065 | 25963 | 63418937 |
| Rales | 26.32 | 14.80 | 38 | 44084 | 12659 | 63432241 |
| Band neutrophil count increased | 26.23 | 14.80 | 10 | 44112 | 385 | 63444515 |
| Concussion | 25.81 | 14.80 | 32 | 44090 | 9212 | 63435688 |
| Dizziness | 25.53 | 14.80 | 430 | 43692 | 429495 | 63015405 |
| Hepatic enzyme increased | 25.52 | 14.80 | 65 | 44057 | 202263 | 63242637 |
| Tinnitus | 25.48 | 14.80 | 68 | 44054 | 35560 | 63409340 |
| Anuria | 25.20 | 14.80 | 37 | 44085 | 12514 | 63432386 |
| Noninfective encephalitis | 25.09 | 14.80 | 10 | 44112 | 434 | 63444466 |
| Extrapyramidal disorder | 25.01 | 14.80 | 38 | 44084 | 13246 | 63431654 |
| Mean cell volume decreased | 24.35 | 14.80 | 21 | 44101 | 3957 | 63440943 |
| Multiple organ dysfunction syndrome | 24.13 | 14.80 | 5 | 44117 | 56747 | 63388153 |
| Myelocyte percentage increased | 24.03 | 14.80 | 8 | 44114 | 206 | 63444694 |
| Gingival bleeding | 23.69 | 14.80 | 36 | 44086 | 12551 | 63432349 |
| Lip pruritus | 23.50 | 14.80 | 12 | 44110 | 935 | 63443965 |
| Abdominal pain | 23.46 | 14.80 | 309 | 43813 | 293147 | 63151753 |
| Vertigo | 23.43 | 14.80 | 93 | 44029 | 59794 | 63385106 |
| Palpitations | 23.26 | 14.80 | 146 | 43976 | 112624 | 63332276 |
| Maternal exposure during pregnancy | 23.16 | 14.80 | 77 | 44045 | 219985 | 63224915 |
| Angioedema | 23.12 | 14.80 | 3 | 44119 | 47962 | 63396938 |
| Personality disorder | 22.82 | 14.80 | 24 | 44098 | 5787 | 63439113 |
| Teratoma benign | 22.69 | 14.80 | 6 | 44116 | 67 | 63444833 |
| Monocyte count increased | 22.65 | 14.80 | 27 | 44095 | 7466 | 63437434 |
| Inflammation | 22.58 | 14.80 | 115 | 44007 | 82158 | 63362742 |
| Discomfort | 22.50 | 14.80 | 52 | 44070 | 167322 | 63277578 |
| Immune thrombocytopenia | 22.48 | 14.80 | 32 | 44090 | 10524 | 63434376 |
| Therapeutic response shortened | 22.37 | 14.80 | 34 | 44088 | 11854 | 63433046 |
| Mean cell volume increased | 22.25 | 14.80 | 19 | 44103 | 3532 | 63441368 |
| Injection site extravasation | 22.15 | 14.80 | 29 | 44093 | 8812 | 63436088 |
| Renal pain | 21.99 | 14.80 | 25 | 44097 | 6574 | 63438326 |
| Musculoskeletal disorder | 21.95 | 14.80 | 46 | 44076 | 20598 | 63424302 |
| Poor quality sleep | 21.88 | 14.80 | 45 | 44077 | 19890 | 63425010 |
| Retinal depigmentation | 21.57 | 14.80 | 8 | 44114 | 285 | 63444615 |
| Chronic kidney disease | 21.50 | 14.80 | 3 | 44119 | 45395 | 63399505 |
| Urobilinogen urine increased | 21.34 | 14.80 | 8 | 44114 | 294 | 63444606 |
| Coma | 21.31 | 14.80 | 9 | 44113 | 64355 | 63380545 |
| Thyroid disorder | 21.29 | 14.80 | 38 | 44084 | 15124 | 63429776 |
| Infusion site discomfort | 21.29 | 14.80 | 13 | 44109 | 1433 | 63443467 |
| Pain | 20.86 | 14.80 | 376 | 43746 | 740252 | 62704648 |
| Nasopharyngitis | 20.85 | 14.80 | 269 | 43853 | 253988 | 63190912 |
| Knee arthroplasty | 20.66 | 14.80 | 6 | 44116 | 54200 | 63390700 |
| Rhabdomyolysis | 20.59 | 14.80 | 3 | 44119 | 43948 | 63400952 |
| Hypoglycaemia | 20.54 | 14.80 | 8 | 44114 | 60057 | 63384843 |
| Seizure | 20.54 | 14.80 | 38 | 44084 | 132596 | 63312304 |
| Infusion site scar | 20.23 | 14.80 | 9 | 44113 | 515 | 63444385 |
| Vision blurred | 20.21 | 14.80 | 121 | 44001 | 91803 | 63353097 |
| Productive cough | 19.97 | 14.80 | 92 | 44030 | 63116 | 63381784 |
| Interstitial lung disease | 19.96 | 14.80 | 9 | 44113 | 61899 | 63383001 |
| Infusion site extravasation | 19.88 | 14.80 | 30 | 44092 | 10396 | 63434504 |
| Gestational hypertension | 19.52 | 14.80 | 15 | 44107 | 2402 | 63442498 |
| Breast cancer | 19.10 | 14.80 | 5 | 44117 | 48378 | 63396522 |
| Gastrointestinal haemorrhage | 19.04 | 14.80 | 17 | 44105 | 81159 | 63363741 |
| Thyroid cyst | 18.97 | 14.80 | 9 | 44113 | 598 | 63444302 |
| Allergic sinusitis | 18.90 | 14.80 | 11 | 44111 | 1111 | 63443789 |
| Immature granulocyte count increased | 18.82 | 14.80 | 8 | 44114 | 410 | 63444490 |
| Anxiety | 18.61 | 14.80 | 232 | 43890 | 217309 | 63227591 |
| Drug ineffective for unapproved indication | 18.57 | 14.80 | 59 | 44063 | 34004 | 63410896 |
| Fumbling | 18.42 | 14.80 | 6 | 44116 | 144 | 63444756 |
| Adverse drug reaction | 18.33 | 14.80 | 17 | 44105 | 79697 | 63365203 |
| Klebsiella test positive | 18.32 | 14.80 | 11 | 44111 | 1176 | 63443724 |
| Thyroid stimulating immunoglobulin | 18.28 | 14.80 | 5 | 44117 | 64 | 63444836 |
| Pancreatitis relapsing | 18.24 | 14.80 | 10 | 44112 | 900 | 63444000 |
| Ill-defined disorder | 18.14 | 14.80 | 18 | 44104 | 81737 | 63363163 |
| Septic shock | 18.11 | 14.80 | 12 | 44110 | 66617 | 63378283 |
| Limbal swelling | 18.11 | 14.80 | 4 | 44118 | 19 | 63444881 |
| Deep vein thrombosis | 17.97 | 14.80 | 19 | 44103 | 83781 | 63361119 |
| Creatinine urine increased | 17.92 | 14.80 | 7 | 44115 | 288 | 63444612 |
| Suicide attempt | 17.92 | 14.80 | 10 | 44112 | 60908 | 63383992 |
| Mental status changes | 17.88 | 14.80 | 3 | 44119 | 39596 | 63405304 |
| Haematocrit increased | 17.84 | 14.80 | 14 | 44108 | 2312 | 63442588 |
| Endometrial ablation | 17.70 | 14.80 | 10 | 44112 | 954 | 63443946 |
| Sinus congestion | 17.68 | 14.80 | 39 | 44083 | 18084 | 63426816 |
| Sneezing | 17.55 | 14.80 | 39 | 44083 | 18179 | 63426721 |
| Apallic syndrome | 17.50 | 14.80 | 9 | 44113 | 712 | 63444188 |
| Menstrual disorder | 17.49 | 14.80 | 20 | 44102 | 5293 | 63439607 |
| Sensory loss | 17.48 | 14.80 | 28 | 44094 | 10210 | 63434690 |
| Arthritis | 17.42 | 14.80 | 139 | 43983 | 115782 | 63329118 |
| Hypoxic-ischaemic encephalopathy | 17.36 | 14.80 | 18 | 44104 | 4269 | 63440631 |
| Metabolic acidosis | 17.16 | 14.80 | 5 | 44117 | 45064 | 63399836 |
| Lipaemic index score | 17.08 | 14.80 | 5 | 44117 | 83 | 63444817 |
| Skin papilloma | 16.85 | 14.80 | 19 | 44103 | 4950 | 63439950 |
| Dry throat | 16.66 | 14.80 | 22 | 44100 | 6743 | 63438157 |
| Ascites | 16.48 | 14.80 | 4 | 44118 | 40724 | 63404176 |
| Treatment noncompliance | 16.47 | 14.80 | 3 | 44119 | 37322 | 63407578 |
| Skin haemorrhage | 16.41 | 14.80 | 27 | 44095 | 10067 | 63434833 |
| Poor feeding infant | 16.39 | 14.80 | 7 | 44115 | 363 | 63444537 |
| Hyperhidrosis | 16.04 | 14.80 | 129 | 43993 | 107707 | 63337193 |
| Blood luteinising hormone decreased | 16.01 | 14.80 | 4 | 44118 | 35 | 63444865 |
| Multiple sclerosis | 15.92 | 14.80 | 45 | 44077 | 24327 | 63420573 |
| Hypokalaemia | 15.84 | 14.80 | 30 | 44092 | 103774 | 63341126 |
| Large intestinal ulcer haemorrhage | 15.72 | 14.80 | 5 | 44117 | 111 | 63444789 |
| Cyanosis neonatal | 15.71 | 14.80 | 7 | 44115 | 402 | 63444498 |
| Infusion site swelling | 15.70 | 14.80 | 26 | 44096 | 9744 | 63435156 |
| Feeling cold | 15.50 | 14.80 | 44 | 44078 | 23844 | 63421056 |
| Nasal congestion | 15.45 | 14.80 | 88 | 44034 | 65572 | 63379328 |
| Eating disorder | 15.36 | 14.80 | 38 | 44084 | 18978 | 63425922 |
| Decerebrate posture | 15.27 | 14.80 | 5 | 44117 | 122 | 63444778 |
| Hemiplegia | 15.24 | 14.80 | 25 | 44097 | 9298 | 63435602 |
| Femur fracture | 15.23 | 14.80 | 5 | 44117 | 41751 | 63403149 |
| Motor dysfunction | 15.15 | 14.80 | 27 | 44095 | 10734 | 63434166 |
| Basophil count increased | 15.11 | 14.80 | 9 | 44113 | 948 | 63443952 |
| Lactic acidosis | 15.03 | 14.80 | 4 | 44118 | 38283 | 63406617 |
| Pollakiuria | 14.87 | 14.80 | 48 | 44074 | 27889 | 63417011 |
| Urine bilirubin increased | 14.86 | 14.80 | 4 | 44118 | 48 | 63444852 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Aplastic anaemia | 310.69 | 17.11 | 121 | 12586 | 9595 | 34934629 |
| Tenosynovitis | 160.60 | 17.11 | 61 | 12646 | 4509 | 34939715 |
| Enthesopathy | 160.05 | 17.11 | 61 | 12646 | 4552 | 34939672 |
| Tongue disorder | 130.99 | 17.11 | 55 | 12652 | 5284 | 34938940 |
| Febrile neutropenia | 127.52 | 17.11 | 199 | 12508 | 136650 | 34807574 |
| C-reactive protein abnormal | 119.80 | 17.11 | 60 | 12647 | 8650 | 34935574 |
| Victim of child abuse | 114.09 | 17.11 | 32 | 12675 | 895 | 34943329 |
| Epidural lipomatosis | 110.03 | 17.11 | 32 | 12675 | 1022 | 34943202 |
| Respiratory depression | 106.68 | 17.11 | 69 | 12638 | 16176 | 34928048 |
| Mucosal inflammation | 102.86 | 17.11 | 96 | 12611 | 38526 | 34905698 |
| Tendonitis | 102.79 | 17.11 | 55 | 12652 | 9085 | 34935139 |
| Alanine aminotransferase abnormal | 97.58 | 17.11 | 43 | 12664 | 4645 | 34939579 |
| Synovitis | 95.46 | 17.11 | 61 | 12646 | 14005 | 34930219 |
| Erythema | 93.78 | 17.11 | 137 | 12570 | 88643 | 34855581 |
| Drug dependence | 86.17 | 17.11 | 71 | 12636 | 24146 | 34920078 |
| Red blood cell sedimentation rate | 81 | 17.11 | 26 | 12681 | 1162 | 34943062 |
| Blood pressure fluctuation | 79.51 | 17.11 | 69 | 12638 | 25180 | 34919044 |
| Granuloma skin | 79.11 | 17.11 | 26 | 12681 | 1253 | 34942971 |
| Loss of personal independence in daily activities | 77.97 | 17.11 | 77 | 12630 | 33102 | 34911122 |
| Juvenile idiopathic arthritis | 76.43 | 17.11 | 28 | 12679 | 1869 | 34942355 |
| Blood parathyroid hormone decreased | 71.53 | 17.11 | 25 | 12682 | 1455 | 34942769 |
| Psoriatic arthropathy | 68.25 | 17.11 | 57 | 12650 | 19741 | 34924483 |
| Panniculitis | 67.83 | 17.11 | 26 | 12681 | 1968 | 34942256 |
| Platelet transfusion | 66.99 | 17.11 | 24 | 12683 | 1502 | 34942722 |
| Product prescribing error | 64.91 | 17.11 | 59 | 12648 | 22868 | 34921356 |
| Nausea | 60.78 | 17.11 | 264 | 12443 | 339644 | 34604580 |
| Death | 59.08 | 17.11 | 36 | 12671 | 398013 | 34546211 |
| Rheumatoid nodule | 58.02 | 17.11 | 26 | 12681 | 2921 | 34941303 |
| Heart rate irregular | 57.59 | 17.11 | 47 | 12660 | 15760 | 34928464 |
| Product use issue | 53.31 | 17.11 | 88 | 12619 | 63128 | 34881096 |
| Foetal exposure during pregnancy | 49.45 | 17.11 | 65 | 12642 | 38036 | 34906188 |
| Child abuse | 44.72 | 17.11 | 13 | 12694 | 414 | 34943810 |
| Urine abnormality | 43.75 | 17.11 | 19 | 12688 | 1980 | 34942244 |
| Inappropriate schedule of product administration | 43.74 | 17.11 | 80 | 12627 | 62216 | 34882008 |
| Lymphocyte percentage decreased | 42.58 | 17.11 | 19 | 12688 | 2113 | 34942111 |
| Infusion related reaction | 42.24 | 17.11 | 72 | 12635 | 52985 | 34891239 |
| Alanine aminotransferase increased | 41.42 | 17.11 | 91 | 12616 | 80724 | 34863500 |
| Aspartate aminotransferase increased | 41.36 | 17.11 | 82 | 12625 | 67701 | 34876523 |
| Skin necrosis | 41.23 | 17.11 | 26 | 12681 | 5827 | 34938397 |
| Umbilical hernia | 38.63 | 17.11 | 23 | 12684 | 4654 | 34939570 |
| Hypercalcaemia | 38.37 | 17.11 | 37 | 12670 | 15431 | 34928793 |
| Heart rate decreased | 37.89 | 17.11 | 52 | 12655 | 31693 | 34912531 |
| Treatment failure | 36.68 | 17.11 | 63 | 12644 | 46634 | 34897590 |
| Perineal infection | 35.57 | 17.11 | 12 | 12695 | 627 | 34943597 |
| Scrotal infection | 35.32 | 17.11 | 12 | 12695 | 641 | 34943583 |
| Dermal cyst | 35.25 | 17.11 | 16 | 12691 | 1851 | 34942373 |
| Tooth injury | 34.95 | 17.11 | 14 | 12693 | 1191 | 34943033 |
| Optic nerve operation | 34.54 | 17.11 | 11 | 12696 | 479 | 34943745 |
| Ulcer | 33.72 | 17.11 | 27 | 12680 | 8808 | 34935416 |
| Off label use | 32.77 | 17.11 | 262 | 12445 | 419262 | 34524962 |
| Neutrophil percentage increased | 32.39 | 17.11 | 15 | 12692 | 1818 | 34942406 |
| Infected dermal cyst | 31.64 | 17.11 | 12 | 12695 | 882 | 34943342 |
| Congenital skin dimples | 30.70 | 17.11 | 8 | 12699 | 168 | 34944056 |
| Obesity | 30.44 | 17.11 | 30 | 12677 | 12848 | 34931376 |
| Transfusion | 30.16 | 17.11 | 25 | 12682 | 8560 | 34935664 |
| C-reactive protein increased | 30.09 | 17.11 | 63 | 12644 | 54035 | 34890189 |
| Lymphocyte count decreased | 28.42 | 17.11 | 38 | 12669 | 22584 | 34921640 |
| Contraindicated product administered | 28.40 | 17.11 | 37 | 12670 | 21444 | 34922780 |
| Anaemia | 28.21 | 17.11 | 26 | 12681 | 233309 | 34710915 |
| Epispadias | 26.38 | 17.11 | 7 | 12700 | 158 | 34944066 |
| Arteriovenous fistula | 25.76 | 17.11 | 11 | 12696 | 1100 | 34943124 |
| pH urine increased | 25.72 | 17.11 | 6 | 12701 | 78 | 34944146 |
| Tendon pain | 25.44 | 17.11 | 15 | 12692 | 2980 | 34941244 |
| Vomiting | 25.23 | 17.11 | 165 | 12542 | 247456 | 34696768 |
| Drug interaction | 25.22 | 17.11 | 27 | 12680 | 225919 | 34718305 |
| Cholinergic syndrome | 24.89 | 17.11 | 9 | 12698 | 578 | 34943646 |
| Anal haemorrhage | 24.80 | 17.11 | 14 | 12693 | 2564 | 34941660 |
| Intentional product use issue | 24.77 | 17.11 | 62 | 12645 | 59754 | 34884470 |
| Infection | 24.75 | 17.11 | 81 | 12626 | 90834 | 34853390 |
| Intracranial aneurysm | 24.10 | 17.11 | 12 | 12695 | 1706 | 34942518 |
| Rheumatoid lung | 24.09 | 17.11 | 10 | 12697 | 932 | 34943292 |
| Drug intolerance | 23.89 | 17.11 | 61 | 12646 | 59509 | 34884715 |
| Rheumatoid arthritis | 22.99 | 17.11 | 46 | 12661 | 38192 | 34906032 |
| Mobility decreased | 22.80 | 17.11 | 40 | 12667 | 30088 | 34914136 |
| Specific gravity urine increased | 22.22 | 17.11 | 6 | 12701 | 145 | 34944079 |
| Urine ketone body present | 22.19 | 17.11 | 10 | 12697 | 1138 | 34943086 |
| Drug hypersensitivity | 22.15 | 17.11 | 72 | 12635 | 80457 | 34863767 |
| Basal cell carcinoma | 21.66 | 17.11 | 31 | 12676 | 19627 | 34924597 |
| Headache | 21.21 | 17.11 | 135 | 12572 | 200500 | 34743724 |
| Toxicity to various agents | 21.19 | 17.11 | 25 | 12682 | 200337 | 34743887 |
| White blood cells urine positive | 21.06 | 17.11 | 10 | 12697 | 1282 | 34942942 |
| Completed suicide | 20.90 | 17.11 | 5 | 12702 | 98163 | 34846061 |
| Blood pressure systolic increased | 20.74 | 17.11 | 33 | 12674 | 22919 | 34921305 |
| Renal impairment | 19.75 | 17.11 | 5 | 12702 | 94508 | 34849716 |
| Restrictive cardiomyopathy | 19.68 | 17.11 | 8 | 12699 | 707 | 34943517 |
| Anal fistula | 19.54 | 17.11 | 16 | 12691 | 5383 | 34938841 |
| Hyperaesthesia | 19.50 | 17.11 | 15 | 12692 | 4615 | 34939609 |
| Rash pruritic | 19.40 | 17.11 | 35 | 12672 | 26906 | 34917318 |
| Blood pressure systolic abnormal | 19.33 | 17.11 | 14 | 12693 | 3934 | 34940290 |
| Fear of injection | 19.32 | 17.11 | 10 | 12697 | 1542 | 34942682 |
| Urine leukocyte esterase positive | 19.15 | 17.11 | 7 | 12700 | 464 | 34943760 |
| Band neutrophil percentage increased | 19.14 | 17.11 | 5 | 12702 | 106 | 34944118 |
| Hydrothorax | 18.67 | 17.11 | 7 | 12700 | 498 | 34943726 |
| Cardiac arrest | 18.41 | 17.11 | 6 | 12701 | 96153 | 34848071 |
| Hypogonadism | 18.39 | 17.11 | 11 | 12696 | 2244 | 34941980 |
| Pyloric stenosis | 18.13 | 17.11 | 8 | 12699 | 866 | 34943358 |
| Congenital umbilical hernia | 18.08 | 17.11 | 6 | 12701 | 298 | 34943926 |
| Hepatic enzyme increased | 17.77 | 17.11 | 42 | 12665 | 39038 | 34905186 |
| Red blood cell elliptocytes present | 17.68 | 17.11 | 5 | 12702 | 144 | 34944080 |
| Blood pressure diastolic decreased | 17.54 | 17.11 | 19 | 12688 | 9075 | 34935149 |
| Aplasia | 17.46 | 17.11 | 14 | 12693 | 4574 | 34939650 |
| Hypersensitivity | 17.16 | 17.11 | 55 | 12652 | 60980 | 34883244 |
| Drug eruption | 17.15 | 17.11 | 28 | 12679 | 19870 | 34924354 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Urine abnormality | 471.50 | 13.72 | 186 | 54134 | 8033 | 79682035 |
| Aplastic anaemia | 405.92 | 13.72 | 212 | 54108 | 17693 | 79672375 |
| Enthesopathy | 335.34 | 13.72 | 162 | 54158 | 11446 | 79678622 |
| Lymphocyte count decreased | 324.06 | 13.72 | 264 | 54056 | 47025 | 79643043 |
| Tenosynovitis | 309.87 | 13.72 | 169 | 54151 | 15385 | 79674683 |
| Tongue disorder | 298.40 | 13.72 | 159 | 54161 | 13816 | 79676252 |
| Urine leukocyte esterase positive | 286.22 | 13.72 | 107 | 54213 | 3984 | 79686084 |
| White blood cells urine positive | 229.11 | 13.72 | 102 | 54218 | 5973 | 79684095 |
| Blood parathyroid hormone decreased | 225.29 | 13.72 | 120 | 54200 | 10416 | 79679652 |
| Red blood cell sedimentation rate | 214.89 | 13.72 | 95 | 54225 | 5470 | 79684598 |
| Panniculitis | 209.93 | 13.72 | 121 | 54199 | 12250 | 79677818 |
| Granuloma skin | 203.26 | 13.72 | 107 | 54213 | 9067 | 79681001 |
| Tendonitis | 199.94 | 13.72 | 150 | 54170 | 23680 | 79666388 |
| Death | 193.93 | 13.72 | 72 | 54248 | 566442 | 79123626 |
| Red blood cells urine positive | 189.31 | 13.72 | 84 | 54236 | 4879 | 79685189 |
| Blood urine present | 185.26 | 13.72 | 137 | 54183 | 21160 | 79668908 |
| Rheumatoid nodule | 178.84 | 13.72 | 124 | 54196 | 17314 | 79672754 |
| Alanine aminotransferase abnormal | 178.42 | 13.72 | 97 | 54223 | 8770 | 79681298 |
| Urinary sediment present | 176.23 | 13.72 | 66 | 54254 | 2469 | 79687599 |
| Skin necrosis | 172.45 | 13.72 | 123 | 54197 | 17964 | 79672104 |
| Urine ketone body present | 164.40 | 13.72 | 69 | 54251 | 3496 | 79686572 |
| Febrile neutropenia | 158.30 | 13.72 | 428 | 53892 | 230571 | 79459497 |
| Chest discomfort | 156.67 | 13.72 | 312 | 54008 | 137732 | 79552336 |
| Flushing | 141.67 | 13.72 | 232 | 54088 | 88036 | 79602032 |
| Nausea | 141.65 | 13.72 | 1123 | 53197 | 956073 | 78733995 |
| Urine analysis abnormal | 141.48 | 13.72 | 75 | 54245 | 6445 | 79683623 |
| C-reactive protein abnormal | 137.17 | 13.72 | 167 | 54153 | 48200 | 79641868 |
| Ulcer | 134.91 | 13.72 | 132 | 54188 | 29840 | 79660228 |
| Crystal urine present | 127.79 | 13.72 | 50 | 54270 | 2110 | 79687958 |
| Loss of personal independence in daily activities | 122.59 | 13.72 | 237 | 54083 | 102343 | 79587725 |
| Lymphocyte percentage decreased | 118.72 | 13.72 | 61 | 54259 | 4915 | 79685153 |
| Erythema | 116.86 | 13.72 | 376 | 53944 | 222914 | 79467154 |
| Hypercalcaemia | 116.04 | 13.72 | 137 | 54183 | 38293 | 79651775 |
| Toxicity to various agents | 114.59 | 13.72 | 73 | 54247 | 421467 | 79268601 |
| Red cell distribution width increased | 112.66 | 13.72 | 89 | 54231 | 15153 | 79674915 |
| Drug interaction | 111.35 | 13.72 | 73 | 54247 | 415110 | 79274958 |
| Fear of injection | 110.80 | 13.72 | 67 | 54253 | 7407 | 79682661 |
| Basal cell carcinoma | 104.27 | 13.72 | 128 | 54192 | 37247 | 79652821 |
| Gastric disorder | 104.11 | 13.72 | 128 | 54192 | 37305 | 79652763 |
| Blood pressure fluctuation | 103.04 | 13.72 | 173 | 54147 | 66972 | 79623096 |
| Completed suicide | 103.01 | 13.72 | 21 | 54299 | 245746 | 79444322 |
| Neovascularisation | 99.80 | 13.72 | 36 | 54284 | 1209 | 79688859 |
| Headache | 99.61 | 13.72 | 773 | 53547 | 652999 | 79037069 |
| Acute kidney injury | 99.24 | 13.72 | 125 | 54195 | 519279 | 79170789 |
| Neutrophil percentage increased | 99.09 | 13.72 | 53 | 54267 | 4636 | 79685432 |
| Culture urine positive | 96.18 | 13.72 | 51 | 54269 | 4384 | 79685684 |
| Specific gravity urine decreased | 95.96 | 13.72 | 32 | 54288 | 846 | 79689222 |
| Victim of child abuse | 93.39 | 13.72 | 32 | 54288 | 921 | 79689147 |
| Haemoglobin urine present | 93.32 | 13.72 | 32 | 54288 | 923 | 79689145 |
| Bacterial test positive | 93.31 | 13.72 | 60 | 54260 | 7389 | 79682679 |
| Bacterial test | 92.95 | 13.72 | 34 | 54286 | 1189 | 79688879 |
| Oesophageal spasm | 90.14 | 13.72 | 45 | 54275 | 3411 | 79686657 |
| Epidural lipomatosis | 85.46 | 13.72 | 32 | 54288 | 1196 | 79688872 |
| Anaemia | 84.03 | 13.72 | 108 | 54212 | 444907 | 79245161 |
| Eosinophil percentage increased | 82.32 | 13.72 | 33 | 54287 | 1485 | 79688583 |
| Rash pruritic | 81.32 | 13.72 | 162 | 54158 | 71467 | 79618601 |
| Drug eruption | 79.45 | 13.72 | 122 | 54198 | 43813 | 79646255 |
| Feeling hot | 77.52 | 13.72 | 143 | 54177 | 59591 | 79630477 |
| Eosinophil count increased | 76.34 | 13.72 | 75 | 54245 | 17030 | 79673038 |
| Oesophageal pain | 75.66 | 13.72 | 43 | 54277 | 4236 | 79685832 |
| Insomnia | 74.07 | 13.72 | 347 | 53973 | 244823 | 79445245 |
| Heart rate irregular | 74.06 | 13.72 | 101 | 54219 | 32578 | 79657490 |
| Urticaria | 73.66 | 13.72 | 285 | 54035 | 184916 | 79505152 |
| Psoriatic arthropathy | 71.84 | 13.72 | 162 | 54158 | 77837 | 79612231 |
| Monocyte percentage increased | 71.40 | 13.72 | 33 | 54287 | 2108 | 79687960 |
| Arterial occlusive disease | 70.41 | 13.72 | 53 | 54267 | 8403 | 79681665 |
| Poor venous access | 69.03 | 13.72 | 73 | 54247 | 18076 | 79671992 |
| Hyponatraemia | 68.93 | 13.72 | 18 | 54302 | 177830 | 79512238 |
| Body temperature increased | 68.87 | 13.72 | 115 | 54205 | 44305 | 79645763 |
| Rheumatoid lung | 67.99 | 13.72 | 40 | 54280 | 4205 | 79685863 |
| Alanine aminotransferase increased | 67.79 | 13.72 | 254 | 54066 | 162316 | 79527752 |
| Skin ulcer | 66.98 | 13.72 | 127 | 54193 | 54023 | 79636045 |
| Infusion site pain | 66.73 | 13.72 | 64 | 54256 | 14112 | 79675956 |
| Gangrene | 65.51 | 13.72 | 52 | 54268 | 8912 | 79681156 |
| Inappropriate schedule of product administration | 65.33 | 13.72 | 220 | 54100 | 133408 | 79556660 |
| Heart rate decreased | 64.71 | 13.72 | 146 | 54174 | 70170 | 79619898 |
| Heart sounds | 62.98 | 13.72 | 24 | 54296 | 942 | 79689126 |
| Oropharyngeal pain | 62.52 | 13.72 | 190 | 54130 | 109163 | 79580905 |
| Hyperkalaemia | 62.10 | 13.72 | 4 | 54316 | 114394 | 79575674 |
| Drug tolerance decreased | 61.86 | 13.72 | 59 | 54261 | 12919 | 79677149 |
| Granuloma | 60.35 | 13.72 | 48 | 54272 | 8249 | 79681819 |
| Migraine | 58.69 | 13.72 | 161 | 54159 | 87332 | 79602736 |
| Mean cell haemoglobin concentration increased | 57.31 | 13.72 | 22 | 54298 | 881 | 79689187 |
| Prolonged expiration | 56.60 | 13.72 | 24 | 54296 | 1247 | 79688821 |
| Drug tolerance | 56.39 | 13.72 | 47 | 54273 | 8628 | 79681440 |
| Blood creatinine decreased | 56.34 | 13.72 | 45 | 54275 | 7780 | 79682288 |
| Multiple sclerosis relapse | 56.15 | 13.72 | 108 | 54212 | 46425 | 79643643 |
| Monocyte count decreased | 56.15 | 13.72 | 32 | 54288 | 3169 | 79686899 |
| Cardiac failure | 55.72 | 13.72 | 18 | 54302 | 154824 | 79535244 |
| Renal failure | 54.26 | 13.72 | 35 | 54285 | 200933 | 79489135 |
| Cardiac failure congestive | 54.06 | 13.72 | 15 | 54305 | 142387 | 79547681 |
| Myocardial reperfusion injury | 53.65 | 13.72 | 13 | 54307 | 101 | 79689967 |
| Alveolitis | 53.18 | 13.72 | 34 | 54286 | 4146 | 79685922 |
| Aspartate aminotransferase increased | 51.59 | 13.72 | 209 | 54111 | 138432 | 79551636 |
| pH urine increased | 51.50 | 13.72 | 17 | 54303 | 435 | 79689633 |
| Specific gravity urine increased | 50.99 | 13.72 | 17 | 54303 | 449 | 79689619 |
| Heart rate increased | 50.62 | 13.72 | 189 | 54131 | 120535 | 79569533 |
| Protein urine present | 50.16 | 13.72 | 47 | 54273 | 10065 | 79680003 |
| Blood uric acid decreased | 49.76 | 13.72 | 22 | 54298 | 1266 | 79688802 |
| C-reactive protein increased | 49.20 | 13.72 | 196 | 54124 | 128831 | 79561237 |
| Red blood cell sedimentation rate increased | 48.68 | 13.72 | 101 | 54219 | 45841 | 79644227 |
| Red cell distribution width decreased | 48.66 | 13.72 | 25 | 54295 | 2013 | 79688055 |
| Transfusion | 48.44 | 13.72 | 66 | 54254 | 21264 | 79668804 |
| Infusion related reaction | 48.39 | 13.72 | 295 | 54025 | 229942 | 79460126 |
| Platelet transfusion | 48.17 | 13.72 | 26 | 54294 | 2316 | 79687752 |
| Nitrite urine present | 47.84 | 13.72 | 21 | 54299 | 1188 | 79688880 |
| Oedema peripheral | 47.78 | 13.72 | 61 | 54259 | 252227 | 79437841 |
| Hand deformity | 47.63 | 13.72 | 7 | 54313 | 103912 | 79586156 |
| Multiple organ dysfunction syndrome | 46.91 | 13.72 | 12 | 54308 | 120234 | 79569834 |
| Interstitial lung disease | 46.37 | 13.72 | 10 | 54310 | 112590 | 79577478 |
| Confusional state | 45.12 | 13.72 | 93 | 54227 | 317904 | 79372164 |
| Disease progression | 44.68 | 13.72 | 36 | 54284 | 184326 | 79505742 |
| Joint injury | 44.46 | 13.72 | 78 | 54242 | 31257 | 79658811 |
| Band neutrophil percentage increased | 44.37 | 13.72 | 15 | 54305 | 414 | 79689654 |
| Body temperature decreased | 44.29 | 13.72 | 79 | 54241 | 32066 | 79658002 |
| Blood thyroid stimulating hormone increased | 44.13 | 13.72 | 43 | 54277 | 9665 | 79680403 |
| Lymphoedema | 43.82 | 13.72 | 48 | 54272 | 12365 | 79677703 |
| Leukocyturia | 43.56 | 13.72 | 23 | 54297 | 1960 | 79688108 |
| Respiratory depression | 43.45 | 13.72 | 72 | 54248 | 27558 | 79662510 |
| Blue toe syndrome | 43.32 | 13.72 | 16 | 54304 | 575 | 79689493 |
| Renal impairment | 43.24 | 13.72 | 27 | 54293 | 157756 | 79532312 |
| Paradoxical drug reaction | 42.75 | 13.72 | 37 | 54283 | 7148 | 79682920 |
| Wound | 42.70 | 13.72 | 13 | 54307 | 116166 | 79573902 |
| Blood pressure systolic increased | 42.69 | 13.72 | 121 | 54199 | 66865 | 79623203 |
| Respiratory failure | 41.78 | 13.72 | 37 | 54283 | 180874 | 79509194 |
| Stress | 41.51 | 13.72 | 134 | 54186 | 79478 | 79610590 |
| Rhinorrhoea | 41.45 | 13.72 | 130 | 54190 | 75944 | 79614124 |
| Blood thyroid stimulating hormone decreased | 41.43 | 13.72 | 33 | 54287 | 5683 | 79684385 |
| Blood pressure increased | 39.57 | 13.72 | 263 | 54057 | 211097 | 79478971 |
| Cystitis | 39.38 | 13.72 | 101 | 54219 | 52631 | 79637437 |
| Band sensation | 38.86 | 13.72 | 16 | 54304 | 772 | 79689296 |
| Mean cell haemoglobin concentration decreased | 38.79 | 13.72 | 29 | 54291 | 4550 | 79685518 |
| Influenza | 38.76 | 13.72 | 183 | 54137 | 129423 | 79560645 |
| Red blood cell count increased | 38.69 | 13.72 | 28 | 54292 | 4180 | 79685888 |
| Creatinine urine decreased | 38.59 | 13.72 | 12 | 54308 | 252 | 79689816 |
| Gastrointestinal haemorrhage | 38.15 | 13.72 | 27 | 54293 | 147692 | 79542376 |
| Product dose omission issue | 38.06 | 13.72 | 69 | 54251 | 247468 | 79442600 |
| Coma | 37.46 | 13.72 | 11 | 54309 | 100638 | 79589430 |
| Band neutrophil count increased | 37.42 | 13.72 | 15 | 54305 | 675 | 79689393 |
| Urine leukocyte esterase | 37.39 | 13.72 | 11 | 54309 | 190 | 79689878 |
| Arteriovenous fistula occlusion | 37.02 | 13.72 | 14 | 54306 | 538 | 79689530 |
| Inflammation | 37.01 | 13.72 | 144 | 54176 | 93609 | 79596459 |
| Red blood cells urine | 36.94 | 13.72 | 15 | 54305 | 698 | 79689370 |
| Child abuse | 36.63 | 13.72 | 13 | 54307 | 416 | 79689652 |
| Musculoskeletal disorder | 36.59 | 13.72 | 58 | 54262 | 21390 | 79668678 |
| Mucosal inflammation | 36.53 | 13.72 | 124 | 54196 | 75456 | 79614612 |
| Haematocrit decreased | 36.41 | 13.72 | 108 | 54212 | 61204 | 79628864 |
| Respiration abnormal | 36.35 | 13.72 | 35 | 54285 | 7753 | 79682315 |
| Drug dependence | 35.67 | 13.72 | 83 | 54237 | 40686 | 79649382 |
| Juvenile idiopathic arthritis | 35.60 | 13.72 | 28 | 54292 | 4735 | 79685333 |
| Neurologic neglect syndrome | 35.39 | 13.72 | 23 | 54297 | 2884 | 79687184 |
| Rhabdomyolysis | 35.35 | 13.72 | 13 | 54307 | 103118 | 79586950 |
| Mean cell haemoglobin decreased | 34.92 | 13.72 | 31 | 54289 | 6193 | 79683875 |
| Thrombocytopenia | 34.79 | 13.72 | 81 | 54239 | 265178 | 79424890 |
| Swelling | 34.58 | 13.72 | 59 | 54261 | 216652 | 79473416 |
| Carotid artery thrombosis | 34.36 | 13.72 | 23 | 54297 | 3030 | 79687038 |
| Pericarditis | 34.30 | 13.72 | 14 | 54306 | 104222 | 79585846 |
| CFTR gene mutation | 33.85 | 13.72 | 9 | 54311 | 105 | 79689963 |
| Vascular malformation | 33.75 | 13.72 | 12 | 54308 | 386 | 79689682 |
| Cough | 32.80 | 13.72 | 388 | 53932 | 366401 | 79323667 |
| Intestinal pseudo-obstruction | 32.64 | 13.72 | 21 | 54299 | 2588 | 79687480 |
| Palpitations | 32.36 | 13.72 | 171 | 54149 | 126439 | 79563629 |
| Throat irritation | 32.21 | 13.72 | 80 | 54240 | 40866 | 79649202 |
| Paranasal cyst | 32.19 | 13.72 | 12 | 54308 | 443 | 79689625 |
| Red blood cell count decreased | 31.99 | 13.72 | 99 | 54221 | 57414 | 79632654 |
| Rheumatoid arthritis | 31.83 | 13.72 | 247 | 54073 | 208223 | 79481845 |
| Mean cell haemoglobin increased | 31.62 | 13.72 | 25 | 54295 | 4260 | 79685808 |
| Nasopharyngitis | 31.44 | 13.72 | 287 | 54033 | 253594 | 79436474 |
| Product use issue | 31.15 | 13.72 | 247 | 54073 | 209575 | 79480493 |
| Osteomyelitis | 31.08 | 13.72 | 69 | 54251 | 32796 | 79657272 |
| Septic shock | 30.99 | 13.72 | 23 | 54297 | 122778 | 79567290 |
| Urine oxalate increased | 30.94 | 13.72 | 10 | 54310 | 239 | 79689829 |
| Angioedema | 30.80 | 13.72 | 7 | 54313 | 76028 | 79614040 |
| Tri-iodothyronine free decreased | 30.50 | 13.72 | 11 | 54309 | 369 | 79689699 |
| Lactic acidosis | 29.48 | 13.72 | 6 | 54314 | 70353 | 79619715 |
| Thyroxine free increased | 29.09 | 13.72 | 15 | 54305 | 1217 | 79688851 |
| Deep vein thrombosis | 28.80 | 13.72 | 24 | 54296 | 120895 | 79569173 |
| Respiratory tract congestion | 28.73 | 13.72 | 50 | 54270 | 19904 | 79670164 |
| Scrotal infection | 28.72 | 13.72 | 12 | 54308 | 601 | 79689467 |
| Perineal infection | 28.67 | 13.72 | 13 | 54307 | 794 | 79689274 |
| Arthritis | 28.56 | 13.72 | 154 | 54166 | 114726 | 79575342 |
| Feeling abnormal | 28.52 | 13.72 | 196 | 54124 | 159003 | 79531065 |
| Impaired healing | 28.48 | 13.72 | 12 | 54308 | 87643 | 79602425 |
| Red blood cell elliptocytes present | 28.34 | 13.72 | 9 | 54311 | 203 | 79689865 |
| Drug ineffective | 27.98 | 13.72 | 544 | 53776 | 1080369 | 78609699 |
| Blood cholesterol increased | 27.95 | 13.72 | 11 | 54309 | 83709 | 79606359 |
| Feeling cold | 27.94 | 13.72 | 61 | 54259 | 28668 | 79661400 |
| Cardio-respiratory arrest | 27.80 | 13.72 | 20 | 54300 | 108490 | 79581578 |
| Optic nerve operation | 27.78 | 13.72 | 11 | 54309 | 479 | 79689589 |
| Therapeutic response shortened | 27.20 | 13.72 | 43 | 54277 | 15820 | 79674248 |
| Infusion site extravasation | 27.19 | 13.72 | 34 | 54286 | 10074 | 79679994 |
| Chronic kidney disease | 26.98 | 13.72 | 6 | 54314 | 66148 | 79623920 |
| Seizure | 26.95 | 13.72 | 55 | 54265 | 188779 | 79501289 |
| Synovitis | 26.66 | 13.72 | 185 | 54135 | 150549 | 79539519 |
| Crystalluria | 26.64 | 13.72 | 13 | 54307 | 938 | 79689130 |
| Haematocrit increased | 26.52 | 13.72 | 22 | 54298 | 4012 | 79686056 |
| Mean cell volume decreased | 26.49 | 13.72 | 24 | 54296 | 4923 | 79685145 |
| Cardiac arrest | 26.41 | 13.72 | 48 | 54272 | 172048 | 79518020 |
| Myelocyte count increased | 26.10 | 13.72 | 12 | 54308 | 757 | 79689311 |
| Injection site pain | 26.04 | 13.72 | 30 | 54290 | 129808 | 79560260 |
| Neutrophil count increased | 25.88 | 13.72 | 60 | 54260 | 29336 | 79660732 |
| Type 2 diabetes mellitus | 25.82 | 13.72 | 4 | 54316 | 57118 | 79632950 |
| Pneumonia aspiration | 25.51 | 13.72 | 7 | 54313 | 66960 | 79623108 |
| Osteoarthritis | 25.24 | 13.72 | 14 | 54306 | 87295 | 79602773 |
| Orthostatic hypotension | 25.24 | 13.72 | 4 | 54316 | 56160 | 79633908 |
| Treatment noncompliance | 25.19 | 13.72 | 3 | 54317 | 52265 | 79637803 |
| Gastrointestinal disorder | 24.76 | 13.72 | 28 | 54292 | 122177 | 79567891 |
| Depressive symptom | 24.72 | 13.72 | 26 | 54294 | 6397 | 79683671 |
| Coronary artery disease | 24.65 | 13.72 | 7 | 54313 | 65467 | 79624601 |
| Adjustment disorder | 24.61 | 13.72 | 21 | 54299 | 3979 | 79686089 |
| Sleep apnoea syndrome | 24.32 | 13.72 | 67 | 54253 | 36411 | 79653657 |
| Acute myocardial infarction | 24.30 | 13.72 | 11 | 54309 | 77025 | 79613043 |
| Appetite disorder | 24.03 | 13.72 | 28 | 54292 | 7711 | 79682357 |
| Neuropathy peripheral | 23.91 | 13.72 | 37 | 54283 | 141268 | 79548800 |
| Treatment failure | 23.84 | 13.72 | 198 | 54122 | 170288 | 79519780 |
| Gestational hypertension | 23.20 | 13.72 | 15 | 54305 | 1864 | 79688204 |
| Therapy non-responder | 23.12 | 13.72 | 124 | 54196 | 92181 | 79597887 |
| Myelocyte percentage increased | 22.84 | 13.72 | 8 | 54312 | 246 | 79689822 |
| Metabolic acidosis | 22.77 | 13.72 | 14 | 54306 | 82515 | 79607553 |
| Monocyte count increased | 22.73 | 13.72 | 32 | 54288 | 10629 | 79679439 |
| Tinnitus | 22.54 | 13.72 | 74 | 54246 | 44259 | 79645809 |
| Tachycardia | 22.52 | 13.72 | 202 | 54118 | 177566 | 79512502 |
| Angina pectoris | 22.51 | 13.72 | 82 | 54238 | 51650 | 79638418 |
| Fatigue | 22.43 | 13.72 | 808 | 53512 | 928919 | 78761149 |
| Suicidal ideation | 22.42 | 13.72 | 12 | 54308 | 76328 | 79613740 |
| Menstrual disorder | 22.31 | 13.72 | 20 | 54300 | 4047 | 79686021 |
| Hepatic function abnormal | 22.20 | 13.72 | 11 | 54309 | 73096 | 79616972 |
| Aggression | 22.08 | 13.72 | 4 | 54316 | 50954 | 79639114 |
| Dizziness | 22.05 | 13.72 | 491 | 53829 | 525950 | 79164118 |
| Diabetes mellitus | 22.05 | 13.72 | 13 | 54307 | 78377 | 79611691 |
| Infusion site discomfort | 22.03 | 13.72 | 13 | 54307 | 1374 | 79688694 |
| Mastoiditis | 22.02 | 13.72 | 14 | 54306 | 1690 | 79688378 |
| Mental status changes | 22.02 | 13.72 | 9 | 54311 | 66950 | 79623118 |
| Respiratory arrest | 21.95 | 13.72 | 6 | 54314 | 57544 | 79632524 |
| Abdominal pain | 21.93 | 13.72 | 380 | 53940 | 389189 | 79300879 |
| Poor quality sleep | 21.81 | 13.72 | 48 | 54272 | 22674 | 79667394 |
| Suicide attempt | 21.62 | 13.72 | 15 | 54305 | 82917 | 79607151 |
| Haematuria | 21.45 | 13.72 | 10 | 54310 | 68826 | 79621242 |
| Hypokalaemia | 21.37 | 13.72 | 41 | 54279 | 143999 | 79546069 |
| Lip pruritus | 21.24 | 13.72 | 11 | 54309 | 901 | 79689167 |
| Urobilinogen urine increased | 21.14 | 13.72 | 10 | 54310 | 673 | 79689395 |
| Sepsis | 21.09 | 13.72 | 103 | 54217 | 269325 | 79420743 |
| Irritable bowel syndrome | 21.07 | 13.72 | 8 | 54312 | 62233 | 79627835 |
| Retinal depigmentation | 20.92 | 13.72 | 8 | 54312 | 317 | 79689751 |
| Sedation | 20.58 | 13.72 | 5 | 54315 | 51890 | 79638178 |
| Injection site extravasation | 20.58 | 13.72 | 29 | 54291 | 9640 | 79680428 |
| Oedema | 20.53 | 13.72 | 31 | 54289 | 119549 | 79570519 |
| Infected dermal cyst | 20.53 | 13.72 | 12 | 54308 | 1246 | 79688822 |
| Personality disorder | 20.37 | 13.72 | 23 | 54297 | 6123 | 79683945 |
| Dermal cyst | 20.29 | 13.72 | 16 | 54304 | 2716 | 79687352 |
| Cerebral haemorrhage | 20.22 | 13.72 | 7 | 54313 | 57666 | 79632402 |
| Pleural effusion | 20.14 | 13.72 | 43 | 54277 | 145219 | 79544849 |
| Brain death | 20.12 | 13.72 | 22 | 54298 | 5655 | 79684413 |
| Bone marrow failure | 20.12 | 13.72 | 5 | 54315 | 51102 | 79638966 |
| Acute respiratory distress syndrome | 20.12 | 13.72 | 3 | 54317 | 44064 | 79646004 |
| Infusion site scar | 20.06 | 13.72 | 8 | 54312 | 355 | 79689713 |
| International normalised ratio increased | 19.95 | 13.72 | 17 | 54303 | 84704 | 79605364 |
| Vision blurred | 19.93 | 13.72 | 132 | 54188 | 105766 | 79584302 |
| Tooth injury | 19.81 | 13.72 | 14 | 54306 | 2014 | 79688054 |
| Osteonecrosis of jaw | 19.60 | 13.72 | 3 | 54317 | 43223 | 79646845 |
| Concussion | 19.48 | 13.72 | 28 | 54292 | 9475 | 79680593 |
| Sneezing | 19.37 | 13.72 | 42 | 54278 | 19641 | 79670427 |
| Ascites | 19.26 | 13.72 | 14 | 54306 | 75548 | 79614520 |
| Chills | 19.24 | 13.72 | 180 | 54140 | 160054 | 79530014 |
| Transient ischaemic attack | 19.17 | 13.72 | 6 | 54314 | 52689 | 79637379 |
| Multiple sclerosis | 19.09 | 13.72 | 45 | 54275 | 22237 | 79667831 |
| Drug reaction with eosinophilia and systemic symptoms | 19.01 | 13.72 | 10 | 54310 | 64234 | 79625834 |
| Noninfective encephalitis | 18.94 | 13.72 | 9 | 54311 | 612 | 79689456 |
| Allergic sinusitis | 18.88 | 13.72 | 10 | 54310 | 857 | 79689211 |
| Lipaemic index score | 18.86 | 13.72 | 6 | 54314 | 136 | 79689932 |
| Fumbling | 18.82 | 13.72 | 6 | 54314 | 137 | 79689931 |
| Endometrial ablation | 18.61 | 13.72 | 10 | 54310 | 883 | 79689185 |
| Affect lability | 18.59 | 13.72 | 30 | 54290 | 11229 | 79678839 |
| Agranulocytosis | 18.53 | 13.72 | 4 | 54316 | 45026 | 79645042 |
| Wrong technique in product usage process | 18.42 | 13.72 | 14 | 54306 | 73861 | 79616207 |
| Mean cell volume increased | 18.38 | 13.72 | 22 | 54298 | 6231 | 79683837 |
| Infusion site pruritus | 18.27 | 13.72 | 18 | 54302 | 4100 | 79685968 |
| Syncope | 18.18 | 13.72 | 62 | 54258 | 179387 | 79510681 |
| Thyroid stimulating immunoglobulin | 18.10 | 13.72 | 5 | 54315 | 68 | 79690000 |
| Limbal swelling | 18.02 | 13.72 | 4 | 54316 | 20 | 79690048 |
| Hyperglycaemia | 17.97 | 13.72 | 13 | 54307 | 70322 | 79619746 |
| Rales | 17.80 | 13.72 | 41 | 54279 | 19960 | 79670108 |
| Blister | 17.73 | 13.72 | 34 | 54286 | 119442 | 79570626 |
| Abdominal pain upper | 17.50 | 13.72 | 231 | 54089 | 223588 | 79466480 |
| Gingival bleeding | 17.49 | 13.72 | 36 | 54284 | 16240 | 79673828 |
| Infusion site swelling | 17.44 | 13.72 | 24 | 54296 | 7802 | 79682266 |
| Staphylococcal infection | 17.36 | 13.72 | 9 | 54311 | 58286 | 79631782 |
| Arteriovenous fistula | 17.19 | 13.72 | 11 | 54309 | 1343 | 79688725 |
| Enterococcus test positive | 17.10 | 13.72 | 13 | 54307 | 2091 | 79687977 |
| Klebsiella test positive | 17.07 | 13.72 | 12 | 54308 | 1711 | 79688357 |
| Product prescribing error | 17.00 | 13.72 | 68 | 54252 | 44745 | 79645323 |
| Cerebral infarction | 16.98 | 13.72 | 5 | 54315 | 45671 | 79644397 |
| Intentional product use issue | 16.85 | 13.72 | 168 | 54152 | 151944 | 79538124 |
| Femur fracture | 16.82 | 13.72 | 3 | 54317 | 38649 | 79651419 |
| Infusion site erythema | 16.72 | 13.72 | 26 | 54294 | 9434 | 79680634 |
| Creatinine urine increased | 16.61 | 13.72 | 8 | 54312 | 561 | 79689507 |
| Pneumonia | 16.49 | 13.72 | 334 | 53986 | 659912 | 79030156 |
| Renal pain | 16.36 | 13.72 | 24 | 54296 | 8272 | 79681796 |
| Neutrophil percentage decreased | 16.28 | 13.72 | 9 | 54311 | 840 | 79689228 |
| Foetal heart rate abnormal | 16.27 | 13.72 | 7 | 54313 | 377 | 79689691 |
| Off label use | 16.23 | 13.72 | 764 | 53556 | 906451 | 78783617 |
| Thyroid disorder | 16.15 | 13.72 | 32 | 54288 | 14047 | 79676021 |
| Skin papilloma | 16.15 | 13.72 | 20 | 54300 | 5866 | 79684202 |
| Anxiety | 16.04 | 13.72 | 248 | 54072 | 248264 | 79441804 |
| Immature granulocyte count increased | 16.00 | 13.72 | 8 | 54312 | 608 | 79689460 |
| Blood glucose increased | 15.97 | 13.72 | 34 | 54286 | 114941 | 79575127 |
| Drug abuse | 15.95 | 13.72 | 57 | 54263 | 162634 | 79527434 |
| Muscle spasticity | 15.89 | 13.72 | 41 | 54279 | 21434 | 79668634 |
| Thyroid cyst | 15.88 | 13.72 | 7 | 54313 | 400 | 79689668 |
| Vomiting | 15.84 | 13.72 | 578 | 53742 | 665250 | 79024818 |
| Sinus congestion | 15.78 | 13.72 | 39 | 54281 | 19857 | 79670211 |
| Blood pressure diastolic abnormal | 15.61 | 13.72 | 38 | 54282 | 19164 | 79670904 |
| Vaginal odour | 15.59 | 13.72 | 7 | 54313 | 418 | 79689650 |
| Anuria | 15.49 | 13.72 | 40 | 54280 | 20923 | 79669145 |
| Apallic syndrome | 15.18 | 13.72 | 9 | 54311 | 959 | 79689109 |
| Anal fistula | 15.04 | 13.72 | 21 | 54299 | 6923 | 79683145 |
| Intracranial aneurysm | 15.04 | 13.72 | 17 | 54303 | 4533 | 79685535 |
| Drug resistance | 15.01 | 13.72 | 5 | 54315 | 42208 | 79647860 |
| Hypoglycaemia | 15.00 | 13.72 | 29 | 54291 | 101565 | 79588503 |
| Allergy to arthropod bite | 14.97 | 13.72 | 6 | 54314 | 270 | 79689798 |
| Pancreatitis relapsing | 14.95 | 13.72 | 9 | 54311 | 987 | 79689081 |
| Loefgren syndrome | 14.82 | 13.72 | 5 | 54315 | 137 | 79689931 |
| Adverse drug reaction | 14.82 | 13.72 | 14 | 54306 | 66378 | 79623690 |
| Dry throat | 14.78 | 13.72 | 22 | 54298 | 7684 | 79682384 |
| Sinus disorder | 14.72 | 13.72 | 41 | 54279 | 22423 | 79667645 |
| Blood creatine phosphokinase increased | 14.68 | 13.72 | 14 | 54306 | 66076 | 79623992 |
| Hypogonadism | 14.58 | 13.72 | 11 | 54309 | 1749 | 79688319 |
| Aplasia | 14.53 | 13.72 | 22 | 54298 | 7798 | 79682270 |
| Loss of consciousness | 14.45 | 13.72 | 62 | 54258 | 167881 | 79522187 |
| Hypomagnesaemia | 14.33 | 13.72 | 7 | 54313 | 46904 | 79643164 |
| Sensory loss | 14.28 | 13.72 | 29 | 54291 | 12962 | 79677106 |
| Immune thrombocytopenia | 14.23 | 13.72 | 35 | 54285 | 17770 | 79672298 |
| Cholinergic syndrome | 14.22 | 13.72 | 9 | 54311 | 1078 | 79688990 |
| Haematoma | 14.20 | 13.72 | 9 | 54311 | 52186 | 79637882 |
| Cholestasis | 14.15 | 13.72 | 9 | 54311 | 52100 | 79637968 |
| Cataract | 13.92 | 13.72 | 81 | 54239 | 62039 | 79628029 |
| Liver function test abnormal | 13.92 | 13.72 | 14 | 54306 | 64461 | 79625607 |
| Knee arthroplasty | 13.92 | 13.72 | 6 | 54314 | 43242 | 79646826 |
| Optic neuritis | 13.89 | 13.72 | 24 | 54296 | 9496 | 79680572 |
| Malaise | 13.85 | 13.72 | 434 | 53886 | 489435 | 79200633 |
| Basophil count increased | 13.82 | 13.72 | 10 | 54310 | 1493 | 79688575 |
| Flank pain | 13.78 | 13.72 | 37 | 54283 | 19807 | 79670261 |
None
| Source | Code | Description |
|---|---|---|
| ATC | R06AA11 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Aminoalkyl ethers |
| ATC | R06AA61 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Aminoalkyl ethers |
| CHEBI has role | CHEBI:37955 | H1 receptor antagonists |
| CHEBI has role | CHEBI:50919 | antiemetico |
| MeSH PA | D000932 | Antiemetics |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D005765 | Gastrointestinal Agents |
| MeSH PA | D018494 | Histamine Agents |
| MeSH PA | D006633 | Histamine Antagonists |
| MeSH PA | D006634 | Histamine H1 Antagonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Nausea and vomiting | indication | 16932000 | |
| Motion sickness | indication | 37031009 | DOID:2951 |
| Vertigo | indication | 399153001 | |
| Vomiting | indication | 422400008 | |
| Nausea | indication | 422587007 | |
| Prevention of Motion Sickness | indication | ||
| Prevention of Nausea and Vomiting | indication | ||
| Ménière's disease | off-label use | 13445001 | DOID:9849 |
| Ocular hypertension | contraindication | 4210003 | DOID:9282 |
| Hypophosphatemia | contraindication | 4996001 | |
| Alcoholism | contraindication | 7200002 | |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Low blood pressure | contraindication | 45007003 | |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Hyperglycemia | contraindication | 80394007 | DOID:4195 |
| Chronic idiopathic constipation | contraindication | 82934008 | |
| Gout | contraindication | 90560007 | DOID:13189 |
| Liver function tests abnormal | contraindication | 166603001 | |
| Arterial hemorrhage | contraindication | 234003006 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Bladder outflow obstruction | contraindication | 236645006 | |
| Pyloric obstruction | contraindication | 244815007 | |
| Benign prostatic hyperplasia | contraindication | 266569009 | |
| Retention of urine | contraindication | 267064002 | |
| Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
| Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
| Acute coronary syndrome | contraindication | 394659003 | |
| Disorder of coronary artery | contraindication | 414024009 |
None
None
None
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Histamine H1 receptor | GPCR | ANTAGONIST | Ki | 7.43 | DRUG MATRIX | CHEMBL | |||
| Alpha-2A adrenergic receptor | GPCR | Ki | 5.79 | DRUG MATRIX | |||||
| Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.31 | DRUG MATRIX | |||||
| Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.70 | DRUG MATRIX | |||||
| 5-hydroxytryptamine receptor 2A | GPCR | Ki | 6.70 | DRUG MATRIX | |||||
| 5-hydroxytryptamine receptor 2B | GPCR | Ki | 5.96 | DRUG MATRIX | |||||
| 5-hydroxytryptamine receptor 2C | GPCR | Ki | 6.48 | DRUG MATRIX | |||||
| Alpha-2B adrenergic receptor | GPCR | Ki | 5.60 | DRUG MATRIX | |||||
| Muscarinic acetylcholine receptor M1 | GPCR | Ki | 6.96 | DRUG MATRIX | |||||
| Muscarinic acetylcholine receptor M2 | GPCR | Ki | 6.79 | DRUG MATRIX | |||||
| Muscarinic acetylcholine receptor M3 | GPCR | Ki | 7.02 | DRUG MATRIX | |||||
| Muscarinic acetylcholine receptor M4 | GPCR | Ki | 7.10 | DRUG MATRIX | |||||
| Muscarinic acetylcholine receptor M5 | GPCR | Ki | 6.64 | DRUG MATRIX | |||||
| Sodium-dependent dopamine transporter | Transporter | Ki | 5.75 | DRUG MATRIX | |||||
| Cytochrome P450 2D6 | Enzyme | IC50 | 5.82 | DRUG MATRIX | |||||
| Alpha-1D adrenergic receptor | GPCR | Ki | 5.85 | DRUG MATRIX |
| ID | Source |
|---|---|
| 4018048 | VUID |
| N0000146389 | NUI |
| D00520 | KEGG_DRUG |
| 151666 | RXNORM |
| 4018048 | VANDF |
| C0012381 | UMLSCUI |
| CHEBI:4604 | CHEBI |
| CHEMBL1200406 | ChEMBL_ID |
| DB00985 | DRUGBANK_ID |
| D004111 | MESH_DESCRIPTOR_UI |
| 10660 | PUBCHEM_CID |
| 61 | INN_ID |
| JB937PER5C | UNII |
| 1568 | MMSL |
| 4605 | MMSL |
| 6646 | MMSL |
| d00861 | MMSL |
| 003371 | NDDF |
| 387469006 | SNOMEDCT_US |
| 81073007 | SNOMEDCT_US |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Wal-Dram | HUMAN OTC DRUG LABEL | 1 | 0363-0198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
| Wal-Dram | HUMAN OTC DRUG LABEL | 1 | 0363-0198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
| Wal-Dram | HUMAN OTC DRUG LABEL | 1 | 0363-0198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
| Wal-Dram | HUMAN OTC DRUG LABEL | 1 | 0363-0198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
| Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 0363-1980 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
| Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 0363-1980 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
| Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 0363-1980 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
| Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 0363-1980 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
| Driminate | HUMAN OTC DRUG LABEL | 1 | 0904-2051 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
| Driminate | HUMAN OTC DRUG LABEL | 1 | 0904-2051 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
| Driminate | HUMAN OTC DRUG LABEL | 1 | 0904-2051 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
| Driminate | HUMAN OTC DRUG LABEL | 1 | 0904-2051 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
| Driminate | HUMAN OTC DRUG LABEL | 1 | 0904-2051 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
| Driminate | HUMAN OTC DRUG LABEL | 1 | 0904-2051 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
| Dimenhydrinate | HUMAN OTC DRUG LABEL | 1 | 0904-6772 | TABLET | 50 mg | ORAL | OTC monograph final | 16 sections |
| PhysiciansCare DimenhydrinateMotion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 0924-1006 | TABLET, COATED | 50 mg | ORAL | OTC monograph final | 16 sections |
| Dimenhydrinate | HUMAN OTC DRUG LABEL | 1 | 0924-1007 | TABLET | 50 mg | ORAL | OTC monograph final | 17 sections |
| Gravol | HUMAN OTC DRUG LABEL | 1 | 10237-940 | CAPSULE, LIQUID FILLED | 50 mg | ORAL | OTC monograph final | 15 sections |
| Gravol | HUMAN OTC DRUG LABEL | 1 | 10237-941 | TABLET, COATED | 50 mg | ORAL | OTC monograph final | 15 sections |
| Gravol | HUMAN OTC DRUG LABEL | 1 | 10237-942 | SYRUP | 15 mg | ORAL | OTC monograph final | 15 sections |
| Motion Sickness | HUMAN OTC DRUG LABEL | 1 | 11673-198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
| Motion Sickness | HUMAN OTC DRUG LABEL | 1 | 11673-198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
| Motion Sickness | HUMAN OTC DRUG LABEL | 1 | 11673-198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
| Motion Sickness | HUMAN OTC DRUG LABEL | 1 | 11673-198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
| Motion Sickness | HUMAN OTC DRUG LABEL | 1 | 11673-198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
| Motion Sickness | HUMAN OTC DRUG LABEL | 1 | 11673-198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
| Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 11822-0198 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
| Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 11822-0198 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
| Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 11822-0198 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
| Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 11822-0198 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |