Stem definition | Drug id | CAS RN |
---|---|---|
N-methylated xanthine derivatives | 901 | 523-87-5 |
Molecule | Description |
---|---|
Synonyms:
|
A drug combination that contains diphenhydramine and theophylline. It is used for treating VERTIGO, MOTION SICKNESS, and NAUSEA associated with PREGNANCY.
|
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
May 31, 1972 | FDA | ALRA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Urine abnormality | 411.55 | 15.04 | 157 | 34934 | 6081 | 50563952 |
Lymphocyte count decreased | 319.43 | 15.04 | 209 | 34882 | 26098 | 50543935 |
Urine leukocyte esterase positive | 266.23 | 15.04 | 93 | 34998 | 2790 | 50567243 |
White blood cells urine positive | 201.00 | 15.04 | 86 | 35005 | 4492 | 50565541 |
Blood urine present | 198.66 | 15.04 | 119 | 34972 | 12714 | 50557319 |
Red blood cells urine positive | 194.42 | 15.04 | 73 | 35018 | 2702 | 50567331 |
Enthesopathy | 181.26 | 15.04 | 92 | 34999 | 7101 | 50562932 |
Urinary sediment present | 163.97 | 15.04 | 59 | 35032 | 1932 | 50568101 |
Tongue disorder | 159.86 | 15.04 | 92 | 34999 | 9124 | 50560909 |
Blood parathyroid hormone decreased | 156.32 | 15.04 | 83 | 35008 | 7031 | 50563002 |
Urine ketone body present | 151.27 | 15.04 | 58 | 35033 | 2275 | 50567758 |
Tenosynovitis | 148.22 | 15.04 | 92 | 34999 | 10473 | 50559560 |
Red blood cell sedimentation rate | 143.17 | 15.04 | 63 | 35028 | 3523 | 50566510 |
Panniculitis | 142.48 | 15.04 | 83 | 35008 | 8420 | 50561613 |
Flushing | 130.02 | 15.04 | 194 | 34897 | 66821 | 50503212 |
Granuloma skin | 128.17 | 15.04 | 68 | 35023 | 5750 | 50564283 |
Skin necrosis | 126.16 | 15.04 | 84 | 35007 | 10783 | 50559250 |
Urine analysis abnormal | 125.48 | 15.04 | 61 | 35030 | 4289 | 50565744 |
Crystal urine present | 122.59 | 15.04 | 44 | 35047 | 1430 | 50568603 |
Red cell distribution width increased | 118.72 | 15.04 | 74 | 35017 | 8485 | 50561548 |
Rheumatoid nodule | 116.39 | 15.04 | 85 | 35006 | 12650 | 50557383 |
Aplastic anaemia | 110.39 | 15.04 | 68 | 35023 | 7635 | 50562398 |
Haemoglobin urine present | 106.25 | 15.04 | 34 | 35057 | 772 | 50569261 |
Death | 105.35 | 15.04 | 47 | 35044 | 325332 | 50244701 |
Chest discomfort | 104.35 | 15.04 | 211 | 34880 | 92511 | 50477522 |
Culture urine positive | 101.37 | 15.04 | 49 | 35042 | 3402 | 50566631 |
Alanine aminotransferase abnormal | 101.34 | 15.04 | 52 | 35039 | 4104 | 50565929 |
Ulcer | 100.96 | 15.04 | 95 | 34996 | 20105 | 50549928 |
Bacterial test positive | 97.86 | 15.04 | 53 | 35038 | 4670 | 50565363 |
Tendonitis | 92.10 | 15.04 | 83 | 35008 | 16622 | 50553411 |
Neovascularisation | 90.92 | 15.04 | 32 | 35059 | 981 | 50569052 |
Eosinophil count increased | 87.70 | 15.04 | 62 | 35029 | 8768 | 50561265 |
Fear of injection | 85.23 | 15.04 | 53 | 35038 | 6050 | 50563983 |
Lymphocyte percentage decreased | 80.50 | 15.04 | 39 | 35052 | 2721 | 50567312 |
Bacterial test | 79.46 | 15.04 | 30 | 35061 | 1127 | 50568906 |
Hypercalcaemia | 78.93 | 15.04 | 89 | 35002 | 23263 | 50546770 |
Specific gravity urine decreased | 78.48 | 15.04 | 26 | 35065 | 661 | 50569372 |
Feeling hot | 76.72 | 15.04 | 114 | 34977 | 39088 | 50530945 |
C-reactive protein abnormal | 71.11 | 15.04 | 92 | 34999 | 27717 | 50542316 |
Eosinophil percentage increased | 70.02 | 15.04 | 26 | 35065 | 932 | 50569101 |
Neutrophil percentage increased | 69.05 | 15.04 | 35 | 35056 | 2692 | 50567341 |
Nausea | 67.37 | 15.04 | 765 | 34326 | 704633 | 49865400 |
Basal cell carcinoma | 67.26 | 15.04 | 82 | 35009 | 23274 | 50546759 |
Drug eruption | 64.95 | 15.04 | 81 | 35010 | 23525 | 50546508 |
Monocyte percentage increased | 64.35 | 15.04 | 25 | 35066 | 1016 | 50569017 |
Mean cell haemoglobin concentration increased | 62.75 | 15.04 | 20 | 35071 | 448 | 50569585 |
Insomnia | 62.17 | 15.04 | 263 | 34828 | 174602 | 50395431 |
Infusion site pain | 61.56 | 15.04 | 58 | 35033 | 12288 | 50557745 |
Blood creatinine decreased | 61.48 | 15.04 | 40 | 35051 | 4936 | 50565097 |
Rash pruritic | 59.98 | 15.04 | 114 | 34977 | 47732 | 50522301 |
Urticaria | 59.21 | 15.04 | 211 | 34880 | 129350 | 50440683 |
Gangrene | 58.67 | 15.04 | 38 | 35053 | 4654 | 50565379 |
Arterial occlusive disease | 57.82 | 15.04 | 38 | 35053 | 4770 | 50565263 |
Alveolitis | 56.89 | 15.04 | 30 | 35061 | 2504 | 50567529 |
Monocyte count decreased | 56.06 | 15.04 | 27 | 35064 | 1859 | 50568174 |
Loss of personal independence in daily activities | 55.83 | 15.04 | 139 | 34952 | 69911 | 50500122 |
Body temperature increased | 55.47 | 15.04 | 87 | 35004 | 31254 | 50538779 |
Blood uric acid decreased | 55.37 | 15.04 | 20 | 35071 | 662 | 50569371 |
Paradoxical drug reaction | 54.31 | 15.04 | 33 | 35058 | 3614 | 50566419 |
Poor venous access | 54.30 | 15.04 | 50 | 35041 | 10290 | 50559743 |
Completed suicide | 53.18 | 15.04 | 13 | 35078 | 131876 | 50438157 |
Red cell distribution width decreased | 52.63 | 15.04 | 22 | 35069 | 1083 | 50568950 |
Oropharyngeal pain | 51.44 | 15.04 | 144 | 34947 | 77657 | 50492376 |
Alanine aminotransferase increased | 51.19 | 15.04 | 156 | 34935 | 88203 | 50481830 |
Oesophageal spasm | 51.03 | 15.04 | 27 | 35064 | 2269 | 50567764 |
Heart rate increased | 50.11 | 15.04 | 142 | 34949 | 77108 | 50492925 |
Intestinal pseudo-obstruction | 49.79 | 15.04 | 19 | 35072 | 735 | 50569298 |
Blood thyroid stimulating hormone increased | 49.72 | 15.04 | 38 | 35053 | 6054 | 50563979 |
Blood pressure fluctuation | 49.48 | 15.04 | 89 | 35002 | 35734 | 50534299 |
Headache | 49.37 | 15.04 | 552 | 34539 | 505983 | 50064050 |
Gastric disorder | 48.15 | 15.04 | 79 | 35012 | 29469 | 50540564 |
Drug ineffective | 47.82 | 15.04 | 353 | 34738 | 818980 | 49751053 |
Product dose omission issue | 47.36 | 15.04 | 35 | 35056 | 183803 | 50386230 |
Protein urine present | 47.12 | 15.04 | 35 | 35056 | 5342 | 50564691 |
Mean cell haemoglobin decreased | 46.76 | 15.04 | 29 | 35062 | 3294 | 50566739 |
Red blood cell sedimentation rate increased | 45.73 | 15.04 | 77 | 35014 | 29339 | 50540694 |
Heart sounds | 45.68 | 15.04 | 17 | 35074 | 613 | 50569420 |
Toxicity to various agents | 45.66 | 15.04 | 48 | 35043 | 212451 | 50357582 |
Wound | 45.54 | 15.04 | 9 | 35082 | 105785 | 50464248 |
Skin ulcer | 45.31 | 15.04 | 85 | 35006 | 35233 | 50534800 |
Haematocrit decreased | 44.65 | 15.04 | 84 | 35007 | 34892 | 50535141 |
Neutrophil count increased | 44.42 | 15.04 | 52 | 35039 | 14143 | 50555890 |
Prolonged expiration | 43.45 | 15.04 | 17 | 35074 | 704 | 50569329 |
Creatinine urine decreased | 43.25 | 15.04 | 12 | 35079 | 163 | 50569870 |
Red blood cell count decreased | 42.87 | 15.04 | 81 | 35010 | 33754 | 50536279 |
Nitrite urine present | 42.63 | 15.04 | 18 | 35073 | 909 | 50569124 |
Erythema | 42.15 | 15.04 | 207 | 34884 | 146207 | 50423826 |
Joint injury | 42.10 | 15.04 | 63 | 35028 | 21726 | 50548307 |
Arteriovenous fistula occlusion | 41.92 | 15.04 | 14 | 35077 | 365 | 50569668 |
Hyponatraemia | 41.75 | 15.04 | 8 | 35083 | 96131 | 50473902 |
pH urine increased | 41.60 | 15.04 | 14 | 35077 | 374 | 50569659 |
Body temperature decreased | 41.53 | 15.04 | 54 | 35037 | 16341 | 50553692 |
Acute kidney injury | 41.11 | 15.04 | 59 | 35032 | 227999 | 50342034 |
Blue toe syndrome | 40.98 | 15.04 | 14 | 35077 | 392 | 50569641 |
Drug interaction | 40.77 | 15.04 | 47 | 35044 | 199574 | 50370459 |
Swelling | 40.27 | 15.04 | 48 | 35043 | 200824 | 50369209 |
Confusional state | 39.93 | 15.04 | 42 | 35049 | 185886 | 50384147 |
Cardiac failure congestive | 38.89 | 15.04 | 6 | 35085 | 84376 | 50485657 |
Oesophageal pain | 38.28 | 15.04 | 24 | 35067 | 2778 | 50567255 |
Red blood cells urine | 37.78 | 15.04 | 14 | 35077 | 499 | 50569534 |
Blood pressure increased | 37.44 | 15.04 | 187 | 34904 | 132945 | 50437088 |
Leukocyturia | 37.40 | 15.04 | 17 | 35074 | 1026 | 50569007 |
Urine leukocyte esterase | 36.96 | 15.04 | 10 | 35081 | 123 | 50569910 |
Specific gravity urine increased | 36.72 | 15.04 | 11 | 35080 | 199 | 50569834 |
C-reactive protein increased | 36.30 | 15.04 | 115 | 34976 | 66359 | 50503674 |
Heart rate decreased | 36.28 | 15.04 | 79 | 35012 | 36418 | 50533615 |
Blood thyroid stimulating hormone decreased | 36.21 | 15.04 | 27 | 35064 | 4145 | 50565888 |
Multiple sclerosis relapse | 36.07 | 15.04 | 87 | 35004 | 42877 | 50527156 |
Stress | 35.97 | 15.04 | 100 | 34991 | 53693 | 50516340 |
Thrombocytopenia | 35.96 | 15.04 | 22 | 35069 | 127651 | 50442382 |
Bradycardia | 35.68 | 15.04 | 112 | 34979 | 64314 | 50505719 |
Blood pressure systolic increased | 35.54 | 15.04 | 77 | 35014 | 35372 | 50534661 |
Myelocyte count increased | 34.95 | 15.04 | 12 | 35079 | 341 | 50569692 |
Oedema peripheral | 34.68 | 15.04 | 35 | 35056 | 157926 | 50412107 |
Granuloma | 34.67 | 15.04 | 28 | 35063 | 4830 | 50565203 |
Injection site pain | 34.36 | 15.04 | 17 | 35074 | 111007 | 50459026 |
Chills | 33.21 | 15.04 | 144 | 34947 | 96543 | 50473490 |
Psoriatic arthropathy | 33.01 | 15.04 | 89 | 35002 | 46943 | 50523090 |
Mean cell haemoglobin increased | 32.83 | 15.04 | 20 | 35071 | 2200 | 50567833 |
Tri-iodothyronine free decreased | 32.50 | 15.04 | 11 | 35080 | 299 | 50569734 |
Red blood cell count increased | 32.14 | 15.04 | 21 | 35070 | 2610 | 50567423 |
Impaired healing | 32.07 | 15.04 | 5 | 35086 | 69781 | 50500252 |
Thyroxine free increased | 31.74 | 15.04 | 14 | 35077 | 787 | 50569246 |
Inflammation | 31.57 | 15.04 | 99 | 34992 | 56813 | 50513220 |
Mean cell haemoglobin concentration decreased | 30.55 | 15.04 | 21 | 35070 | 2838 | 50567195 |
Alopecia | 30.54 | 15.04 | 79 | 35012 | 244968 | 50325065 |
Migraine | 30.50 | 15.04 | 118 | 34973 | 75162 | 50494871 |
CFTR gene mutation | 30.46 | 15.04 | 8 | 35083 | 87 | 50569946 |
Band sensation | 30.41 | 15.04 | 13 | 35078 | 677 | 50569356 |
Tachycardia | 30.10 | 15.04 | 143 | 34948 | 99620 | 50470413 |
Crystalluria | 30.06 | 15.04 | 11 | 35080 | 378 | 50569655 |
Angina pectoris | 29.89 | 15.04 | 60 | 35031 | 26128 | 50543905 |
Mean cell volume decreased | 29.73 | 15.04 | 20 | 35071 | 2609 | 50567424 |
Neuropathy peripheral | 29.66 | 15.04 | 15 | 35076 | 96742 | 50473291 |
Paranasal cyst | 29.00 | 15.04 | 10 | 35081 | 288 | 50569745 |
Aspartate aminotransferase increased | 28.98 | 15.04 | 119 | 34972 | 77879 | 50492154 |
Vascular malformation | 28.84 | 15.04 | 10 | 35081 | 293 | 50569740 |
Band neutrophil percentage increased | 27.81 | 15.04 | 9 | 35082 | 212 | 50569821 |
Disease progression | 27.72 | 15.04 | 16 | 35075 | 95850 | 50474183 |
Monocyte count increased | 27.57 | 15.04 | 26 | 35065 | 5513 | 50564520 |
Urinary retention | 27.53 | 15.04 | 58 | 35033 | 26132 | 50543901 |
Anaemia | 27.34 | 15.04 | 87 | 35004 | 252369 | 50317664 |
Throat irritation | 27.30 | 15.04 | 63 | 35028 | 30176 | 50539857 |
Urine oxalate increased | 27.19 | 15.04 | 9 | 35082 | 228 | 50569805 |
Drug ineffective for unapproved indication | 27.02 | 15.04 | 51 | 35040 | 21230 | 50548803 |
Gingival bleeding | 26.61 | 15.04 | 36 | 35055 | 11317 | 50558716 |
Rhinorrhoea | 26.13 | 15.04 | 87 | 35004 | 51496 | 50518537 |
Bulimia nervosa | 25.96 | 15.04 | 10 | 35081 | 397 | 50569636 |
Infection | 25.39 | 15.04 | 51 | 35040 | 172903 | 50397130 |
Renal failure | 25.31 | 15.04 | 22 | 35069 | 106611 | 50463422 |
Cough | 25.26 | 15.04 | 267 | 34824 | 240997 | 50329036 |
Mastoiditis | 24.92 | 15.04 | 12 | 35079 | 826 | 50569207 |
Pericarditis | 24.42 | 15.04 | 12 | 35079 | 78677 | 50491356 |
Infusion site discomfort | 24.38 | 15.04 | 12 | 35079 | 866 | 50569167 |
Injection site extravasation | 24.34 | 15.04 | 28 | 35063 | 7473 | 50562560 |
Myelocyte percentage increased | 24.05 | 15.04 | 8 | 35083 | 206 | 50569827 |
Drug abuse | 23.91 | 15.04 | 6 | 35085 | 59840 | 50510193 |
Band neutrophil count increased | 23.74 | 15.04 | 9 | 35082 | 342 | 50569691 |
Thyroid disorder | 23.56 | 15.04 | 36 | 35055 | 12641 | 50557392 |
Renal pain | 23.53 | 15.04 | 24 | 35067 | 5595 | 50564438 |
Infusion related reaction | 23.39 | 15.04 | 199 | 34892 | 169358 | 50400675 |
Mean cell volume increased | 23.08 | 15.04 | 18 | 35073 | 2954 | 50567079 |
Seizure | 22.73 | 15.04 | 29 | 35062 | 117845 | 50452188 |
Teratoma benign | 22.70 | 15.04 | 6 | 35085 | 67 | 50569966 |
Extrapyramidal disorder | 22.69 | 15.04 | 34 | 35057 | 11736 | 50558297 |
Infusion site extravasation | 22.57 | 15.04 | 26 | 35065 | 6950 | 50563083 |
Dizziness | 22.52 | 15.04 | 351 | 34740 | 346018 | 50224015 |
Anuria | 22.42 | 15.04 | 33 | 35058 | 11211 | 50558822 |
Abdominal pain | 22.23 | 15.04 | 256 | 34835 | 235972 | 50334061 |
Drug tolerance | 22.21 | 15.04 | 22 | 35069 | 4954 | 50565079 |
Myocardial reperfusion injury | 22.11 | 15.04 | 5 | 35086 | 27 | 50570006 |
Depressive symptom | 21.90 | 15.04 | 18 | 35073 | 3182 | 50566851 |
Retinal depigmentation | 21.89 | 15.04 | 8 | 35083 | 274 | 50569759 |
Immune thrombocytopenia | 21.75 | 15.04 | 29 | 35062 | 8988 | 50561045 |
Cardiac failure | 21.55 | 15.04 | 13 | 35078 | 76027 | 50494006 |
Poor quality sleep | 21.27 | 15.04 | 40 | 35051 | 16606 | 50553427 |
Irritable bowel syndrome | 20.86 | 15.04 | 5 | 35086 | 51436 | 50518597 |
Infusion site scar | 20.52 | 15.04 | 8 | 35083 | 328 | 50569705 |
Osteoarthritis | 20.48 | 15.04 | 11 | 35080 | 68595 | 50501438 |
Creatinine urine increased | 20.39 | 15.04 | 7 | 35084 | 199 | 50569834 |
Multiple organ dysfunction syndrome | 20.20 | 15.04 | 5 | 35086 | 50332 | 50519701 |
Lip pruritus | 20.17 | 15.04 | 10 | 35081 | 733 | 50569300 |
Palpitations | 20.03 | 15.04 | 123 | 34968 | 94383 | 50475650 |
Brain death | 19.78 | 15.04 | 16 | 35075 | 2767 | 50567266 |
Cerebrovascular accident | 19.63 | 15.04 | 22 | 35069 | 94658 | 50475375 |
Rales | 19.48 | 15.04 | 29 | 35062 | 9949 | 50560084 |
Urobilinogen urine increased | 19.40 | 15.04 | 7 | 35084 | 231 | 50569802 |
Rheumatoid lung | 19.29 | 15.04 | 15 | 35076 | 2450 | 50567583 |
Maternal exposure during pregnancy | 18.76 | 15.04 | 53 | 35038 | 159725 | 50410308 |
Feeling abnormal | 18.75 | 15.04 | 150 | 34941 | 125342 | 50444691 |
Gestational hypertension | 18.72 | 15.04 | 14 | 35077 | 2159 | 50567874 |
Influenza | 18.63 | 15.04 | 116 | 34975 | 89422 | 50480611 |
Fumbling | 18.59 | 15.04 | 6 | 35085 | 140 | 50569893 |
Lymphoedema | 18.52 | 15.04 | 27 | 35064 | 9095 | 50560938 |
Hypoglycaemia | 18.48 | 15.04 | 7 | 35084 | 53574 | 50516459 |
Gastrointestinal disorder | 18.45 | 15.04 | 23 | 35068 | 94433 | 50475600 |
Drug tolerance decreased | 18.43 | 15.04 | 27 | 35064 | 9133 | 50560900 |
Thyroid stimulating immunoglobulin | 18.29 | 15.04 | 5 | 35086 | 64 | 50569969 |
Interstitial lung disease | 18.26 | 15.04 | 7 | 35084 | 53169 | 50516864 |
Limbal swelling | 18.12 | 15.04 | 4 | 35087 | 19 | 50570014 |
Klebsiella test positive | 18.05 | 15.04 | 10 | 35081 | 921 | 50569112 |
Arthritis | 17.83 | 15.04 | 112 | 34979 | 86609 | 50483424 |
Vaginal discharge | 17.75 | 15.04 | 20 | 35071 | 5220 | 50564813 |
Skin papilloma | 17.60 | 15.04 | 18 | 35073 | 4211 | 50565822 |
Vitamin B12 decreased | 17.54 | 15.04 | 15 | 35076 | 2800 | 50567233 |
Rhabdomyolysis | 17.47 | 15.04 | 3 | 35088 | 39024 | 50531009 |
Ill-defined disorder | 17.47 | 15.04 | 8 | 35083 | 54646 | 50515387 |
Colitis microscopic | 17.34 | 15.04 | 22 | 35069 | 6498 | 50563535 |
Septic shock | 17.32 | 15.04 | 9 | 35082 | 57166 | 50512867 |
Nasopharyngitis | 17.22 | 15.04 | 207 | 34884 | 192720 | 50377313 |
Coma | 17.16 | 15.04 | 9 | 35082 | 56870 | 50513163 |
Lipaemic index score | 17.09 | 15.04 | 5 | 35086 | 83 | 50569950 |
Appetite disorder | 16.85 | 15.04 | 21 | 35070 | 6093 | 50563940 |
Therapy non-responder | 16.75 | 15.04 | 75 | 35016 | 50947 | 50519086 |
Dry throat | 16.72 | 15.04 | 20 | 35071 | 5564 | 50564469 |
Thirst | 16.71 | 15.04 | 28 | 35063 | 10622 | 50559411 |
Immature granulocyte count increased | 16.66 | 15.04 | 7 | 35084 | 349 | 50569684 |
Angioedema | 16.64 | 15.04 | 3 | 35088 | 37673 | 50532360 |
Injection site reaction | 16.50 | 15.04 | 7 | 35084 | 50025 | 50520008 |
Respiration abnormal | 16.48 | 15.04 | 19 | 35072 | 5083 | 50564950 |
Wrong technique in product usage process | 16.43 | 15.04 | 9 | 35082 | 55501 | 50514532 |
Thyroid cyst | 16.42 | 15.04 | 8 | 35083 | 565 | 50569468 |
Gastrointestinal haemorrhage | 16.36 | 15.04 | 16 | 35075 | 73305 | 50496728 |
Allergic sinusitis | 16.34 | 15.04 | 8 | 35083 | 571 | 50569462 |
Basophil count increased | 16.30 | 15.04 | 9 | 35082 | 823 | 50569210 |
Blood cholesterol increased | 16.27 | 15.04 | 9 | 35082 | 55206 | 50514827 |
Productive cough | 16.22 | 15.04 | 76 | 35015 | 52618 | 50517415 |
Vertigo | 16.13 | 15.04 | 75 | 35016 | 51757 | 50518276 |
Injection site bruising | 16.08 | 15.04 | 3 | 35088 | 36765 | 50533268 |
Dyspepsia | 16.05 | 15.04 | 97 | 34994 | 74000 | 50496033 |
Heart rate irregular | 16.03 | 15.04 | 39 | 35052 | 19321 | 50550712 |
Blood luteinising hormone decreased | 16.01 | 15.04 | 4 | 35087 | 35 | 50569998 |
Endometrial ablation | 16.00 | 15.04 | 9 | 35082 | 854 | 50569179 |
Injection site erythema | 15.99 | 15.04 | 17 | 35074 | 74919 | 50495114 |
Suicide attempt | 15.88 | 15.04 | 8 | 35083 | 51724 | 50518309 |
Breast cancer | 15.83 | 15.04 | 5 | 35086 | 42885 | 50527148 |
Large intestinal ulcer haemorrhage | 15.77 | 15.04 | 5 | 35086 | 110 | 50569923 |
Pain | 15.72 | 15.04 | 295 | 34796 | 578608 | 49991425 |
Infusion site swelling | 15.68 | 15.04 | 22 | 35069 | 7154 | 50562879 |
Tinnitus | 15.65 | 15.04 | 49 | 35042 | 28083 | 50541950 |
Hypokalaemia | 15.60 | 15.04 | 23 | 35068 | 87969 | 50482064 |
Cardio-respiratory arrest | 15.57 | 15.04 | 9 | 35082 | 53883 | 50516150 |
Decerebrate posture | 15.44 | 15.04 | 5 | 35086 | 118 | 50569915 |
Haematocrit increased | 15.42 | 15.04 | 12 | 35079 | 1962 | 50568071 |
Chronic gastrointestinal bleeding | 15.36 | 15.04 | 5 | 35086 | 120 | 50569913 |
Menstrual disorder | 15.35 | 15.04 | 17 | 35074 | 4353 | 50565680 |
Urinary casts | 15.31 | 15.04 | 8 | 35083 | 655 | 50569378 |
Metabolic acidosis | 15.30 | 15.04 | 4 | 35087 | 38821 | 50531212 |
Deep vein thrombosis | 15.23 | 15.04 | 17 | 35074 | 73287 | 50496746 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Aplastic anaemia | 200.82 | 17.57 | 79 | 9240 | 7431 | 29557777 |
Tenosynovitis | 146.34 | 17.57 | 52 | 9267 | 3681 | 29561527 |
Enthesopathy | 146.20 | 17.57 | 52 | 9267 | 3691 | 29561517 |
C-reactive protein abnormal | 114.87 | 17.57 | 51 | 9268 | 6485 | 29558723 |
Tongue disorder | 114.25 | 17.57 | 46 | 9273 | 4590 | 29560618 |
Victim of child abuse | 112.05 | 17.57 | 30 | 9289 | 815 | 29564393 |
Synovitis | 92.91 | 17.57 | 52 | 9267 | 10838 | 29554370 |
Alanine aminotransferase abnormal | 92.91 | 17.57 | 35 | 9284 | 2922 | 29562286 |
Tendonitis | 90.42 | 17.57 | 46 | 9273 | 7915 | 29557293 |
Respiratory depression | 84.99 | 17.57 | 53 | 9266 | 13470 | 29551738 |
Erythema | 77.93 | 17.57 | 107 | 9212 | 75499 | 29489709 |
Epidural lipomatosis | 74.60 | 17.57 | 21 | 9298 | 690 | 29564518 |
Psoriatic arthropathy | 71.35 | 17.57 | 49 | 9270 | 14642 | 29550566 |
Drug dependence | 68.26 | 17.57 | 55 | 9264 | 20926 | 29544282 |
Febrile neutropenia | 67.35 | 17.57 | 124 | 9195 | 112116 | 29453092 |
Loss of personal independence in daily activities | 61.00 | 17.57 | 56 | 9263 | 25384 | 29539824 |
Foetal exposure during pregnancy | 50.98 | 17.57 | 58 | 9261 | 33809 | 29531399 |
Product prescribing error | 49.90 | 17.57 | 43 | 9276 | 17933 | 29547275 |
Platelet transfusion | 49.33 | 17.57 | 17 | 9302 | 1097 | 29564111 |
Aspartate aminotransferase increased | 46.30 | 17.57 | 74 | 9245 | 59651 | 29505557 |
Lymphocyte percentage decreased | 46.21 | 17.57 | 19 | 9300 | 1998 | 29563210 |
Heart rate irregular | 46.11 | 17.57 | 36 | 9283 | 13081 | 29552127 |
Urine abnormality | 45.88 | 17.57 | 18 | 9301 | 1676 | 29563532 |
Juvenile idiopathic arthritis | 45.60 | 17.57 | 17 | 9302 | 1377 | 29563831 |
Nausea | 45.04 | 17.57 | 195 | 9124 | 289060 | 29276148 |
Blood pressure fluctuation | 44.23 | 17.57 | 42 | 9277 | 19852 | 29545356 |
Alanine aminotransferase increased | 43.26 | 17.57 | 79 | 9240 | 70865 | 29494343 |
Red blood cell sedimentation rate | 43.22 | 17.57 | 13 | 9306 | 541 | 29564667 |
Mucosal inflammation | 42.36 | 17.57 | 51 | 9268 | 31544 | 29533664 |
Granuloma skin | 41.21 | 17.57 | 13 | 9306 | 635 | 29564573 |
Treatment failure | 40.60 | 17.57 | 54 | 9265 | 36885 | 29528323 |
Death | 39.75 | 17.57 | 30 | 9289 | 342054 | 29223154 |
Blood parathyroid hormone decreased | 38.14 | 17.57 | 13 | 9306 | 811 | 29564397 |
Lymphocyte count decreased | 37.81 | 17.57 | 38 | 9281 | 19233 | 29545975 |
Neutrophil percentage increased | 34.86 | 17.57 | 15 | 9304 | 1766 | 29563442 |
Panniculitis | 33.16 | 17.57 | 13 | 9306 | 1208 | 29564000 |
C-reactive protein increased | 33.13 | 17.57 | 54 | 9265 | 44209 | 29520999 |
Congenital skin dimples | 31.97 | 17.57 | 8 | 9311 | 165 | 29565043 |
Transfusion | 30.00 | 17.57 | 22 | 9297 | 7276 | 29557932 |
Product use issue | 28.48 | 17.57 | 55 | 9264 | 51389 | 29513819 |
Off label use | 27.44 | 17.57 | 175 | 9144 | 300625 | 29264583 |
Epispadias | 27.37 | 17.57 | 7 | 9312 | 158 | 29565050 |
pH urine increased | 26.79 | 17.57 | 6 | 9313 | 75 | 29565133 |
Inappropriate schedule of product administration | 26.42 | 17.57 | 49 | 9270 | 44423 | 29520785 |
Rheumatoid nodule | 26.25 | 17.57 | 13 | 9306 | 2109 | 29563099 |
Drug hypersensitivity | 26.22 | 17.57 | 63 | 9256 | 68343 | 29496865 |
Vomiting | 24.85 | 17.57 | 132 | 9187 | 212128 | 29353080 |
Drug intolerance | 24.70 | 17.57 | 50 | 9269 | 48329 | 29516879 |
Drug interaction | 24.59 | 17.57 | 16 | 9303 | 197369 | 29367839 |
Headache | 24.46 | 17.57 | 114 | 9205 | 173893 | 29391315 |
Contraindicated product administered | 23.68 | 17.57 | 29 | 9290 | 18237 | 29546971 |
White blood cells urine positive | 23.35 | 17.57 | 10 | 9309 | 1164 | 29564044 |
Specific gravity urine increased | 23.23 | 17.57 | 6 | 9313 | 141 | 29565067 |
Urine leukocyte esterase positive | 21.16 | 17.57 | 7 | 9312 | 398 | 29564810 |
Urine ketone body present | 21.08 | 17.57 | 9 | 9310 | 1039 | 29564169 |
Red blood cell elliptocytes present | 20.62 | 17.57 | 5 | 9314 | 90 | 29565118 |
Child abuse | 20.55 | 17.57 | 6 | 9313 | 225 | 29564983 |
Pyloric stenosis | 20.42 | 17.57 | 8 | 9311 | 742 | 29564466 |
Band neutrophil percentage increased | 19.85 | 17.57 | 5 | 9314 | 106 | 29565102 |
Umbilical hernia | 19.41 | 17.57 | 13 | 9306 | 3722 | 29561486 |
Congenital umbilical hernia | 19.14 | 17.57 | 6 | 9313 | 287 | 29564921 |
Infusion related reaction | 18.53 | 17.57 | 42 | 9277 | 43844 | 29521364 |
Obesity | 18.52 | 17.57 | 19 | 9300 | 9844 | 29555364 |
Restrictive cardiomyopathy | 18.46 | 17.57 | 7 | 9312 | 594 | 29564614 |
Aplasia | 18.42 | 17.57 | 13 | 9306 | 4050 | 29561158 |
Heart rate decreased | 18.10 | 17.57 | 30 | 9289 | 24882 | 29540326 |
Neutrophil percentage decreased | 18.04 | 17.57 | 6 | 9313 | 347 | 29564861 |
Hypercalcaemia | 17.75 | 17.57 | 21 | 9298 | 12738 | 29552470 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Urine abnormality | 453.99 | 13.93 | 174 | 42350 | 7188 | 64449020 |
Lymphocyte count decreased | 326.46 | 13.93 | 246 | 42278 | 40453 | 64415755 |
Enthesopathy | 302.62 | 13.93 | 141 | 42383 | 9497 | 64446711 |
Urine leukocyte esterase positive | 278.27 | 13.93 | 99 | 42425 | 3304 | 64452904 |
Tenosynovitis | 275.13 | 13.93 | 141 | 42383 | 11692 | 64444516 |
Aplastic anaemia | 264.59 | 13.93 | 145 | 42379 | 13775 | 64442433 |
Tongue disorder | 260.93 | 13.93 | 137 | 42387 | 11943 | 64444265 |
White blood cells urine positive | 223.97 | 13.93 | 96 | 42428 | 5302 | 64450906 |
Blood parathyroid hormone decreased | 195.42 | 13.93 | 96 | 42428 | 7270 | 64448938 |
Red blood cell sedimentation rate | 187.59 | 13.93 | 76 | 42448 | 3638 | 64452570 |
Blood urine present | 183.91 | 13.93 | 127 | 42397 | 18213 | 64437995 |
Red blood cells urine positive | 180.40 | 13.93 | 78 | 42446 | 4400 | 64451808 |
Panniculitis | 178.48 | 13.93 | 96 | 42428 | 8783 | 64447425 |
Tendonitis | 174.66 | 13.93 | 128 | 42396 | 20154 | 64436054 |
Alanine aminotransferase abnormal | 174.51 | 13.93 | 87 | 42437 | 6801 | 64449407 |
Granuloma skin | 166.64 | 13.93 | 81 | 42443 | 5993 | 64450215 |
Urine ketone body present | 164.72 | 13.93 | 67 | 42457 | 3240 | 64452968 |
Urinary sediment present | 160.24 | 13.93 | 59 | 42465 | 2175 | 64454033 |
C-reactive protein abnormal | 157.83 | 13.93 | 140 | 42384 | 28907 | 64427301 |
Death | 153.98 | 13.93 | 63 | 42461 | 482642 | 63973566 |
Rheumatoid nodule | 151.89 | 13.93 | 98 | 42426 | 12553 | 64443655 |
Skin necrosis | 138.45 | 13.93 | 97 | 42427 | 14232 | 64441976 |
Urine analysis abnormal | 132.08 | 13.93 | 68 | 42456 | 5688 | 64450520 |
Flushing | 131.69 | 13.93 | 207 | 42317 | 78441 | 64377767 |
Crystal urine present | 131.22 | 13.93 | 49 | 42475 | 1880 | 64454328 |
Red cell distribution width increased | 127.57 | 13.93 | 87 | 42437 | 12222 | 64443986 |
Loss of personal independence in daily activities | 120.33 | 13.93 | 190 | 42334 | 72264 | 64383944 |
Nausea | 120.25 | 13.93 | 906 | 41618 | 784894 | 63671314 |
Lymphocyte percentage decreased | 115.64 | 13.93 | 58 | 42466 | 4591 | 64451617 |
Ulcer | 111.55 | 13.93 | 104 | 42420 | 22886 | 64433322 |
Chest discomfort | 111.12 | 13.93 | 240 | 42284 | 115866 | 64340342 |
Psoriatic arthropathy | 106.61 | 13.93 | 137 | 42387 | 43144 | 64413064 |
Drug interaction | 97.64 | 13.93 | 59 | 42465 | 362024 | 64094184 |
Haemoglobin urine present | 97.53 | 13.93 | 32 | 42492 | 831 | 64455377 |
Headache | 96.81 | 13.93 | 638 | 41886 | 528829 | 63927379 |
Erythema | 96.70 | 13.93 | 307 | 42217 | 186763 | 64269445 |
Culture urine positive | 95.13 | 13.93 | 49 | 42475 | 4102 | 64452106 |
Neutrophil percentage increased | 94.80 | 13.93 | 50 | 42474 | 4395 | 64451813 |
Hypercalcaemia | 92.81 | 13.93 | 109 | 42415 | 31307 | 64424901 |
Acute kidney injury | 92.50 | 13.93 | 96 | 42428 | 449144 | 64007064 |
Fear of injection | 91.87 | 13.93 | 54 | 42470 | 5858 | 64450350 |
Eosinophil count increased | 90.88 | 13.93 | 75 | 42449 | 14037 | 64442171 |
Bacterial test positive | 90.76 | 13.93 | 56 | 42468 | 6634 | 64449574 |
Bacterial test | 90.73 | 13.93 | 33 | 42491 | 1174 | 64455034 |
Toxicity to various agents | 90.21 | 13.93 | 65 | 42459 | 363448 | 64092760 |
Completed suicide | 90.16 | 13.93 | 19 | 42505 | 224395 | 64231813 |
Neovascularisation | 89.84 | 13.93 | 32 | 42492 | 1071 | 64455137 |
Victim of child abuse | 89.26 | 13.93 | 30 | 42494 | 841 | 64455367 |
Specific gravity urine decreased | 88.35 | 13.93 | 29 | 42495 | 754 | 64455454 |
Eosinophil percentage increased | 81.87 | 13.93 | 32 | 42492 | 1392 | 64454816 |
Insomnia | 79.81 | 13.93 | 299 | 42225 | 197537 | 64258671 |
Basal cell carcinoma | 78.12 | 13.93 | 99 | 42425 | 30739 | 64425469 |
Blood pressure fluctuation | 77.90 | 13.93 | 130 | 42394 | 51741 | 64404467 |
Feeling hot | 77.52 | 13.93 | 121 | 42403 | 45542 | 64410666 |
Alanine aminotransferase increased | 72.56 | 13.93 | 229 | 42295 | 138802 | 64317406 |
Monocyte percentage increased | 71.38 | 13.93 | 32 | 42492 | 1968 | 64454240 |
Infusion site pain | 70.62 | 13.93 | 57 | 42467 | 10340 | 64445868 |
Urticaria | 69.99 | 13.93 | 235 | 42289 | 147082 | 64309126 |
Rash pruritic | 69.61 | 13.93 | 131 | 42393 | 57273 | 64398935 |
Drug eruption | 63.08 | 13.93 | 97 | 42427 | 36039 | 64420169 |
Poor venous access | 61.83 | 13.93 | 57 | 42467 | 12360 | 64443848 |
Mean cell haemoglobin concentration increased | 60.96 | 13.93 | 22 | 42502 | 765 | 64455443 |
Red cell distribution width decreased | 60.86 | 13.93 | 24 | 42500 | 1069 | 64455139 |
Body temperature increased | 60.63 | 13.93 | 96 | 42428 | 36570 | 64419638 |
Multiple sclerosis relapse | 60.31 | 13.93 | 102 | 42422 | 41033 | 64415175 |
Anaemia | 59.36 | 13.93 | 99 | 42425 | 378581 | 64077627 |
Monocyte count decreased | 57.72 | 13.93 | 31 | 42493 | 2826 | 64453382 |
Gastric disorder | 57.59 | 13.93 | 83 | 42441 | 29114 | 64427094 |
Oropharyngeal pain | 56.46 | 13.93 | 157 | 42367 | 88710 | 64367498 |
Oesophageal spasm | 55.55 | 13.93 | 29 | 42495 | 2496 | 64453712 |
Blood creatinine decreased | 55.12 | 13.93 | 42 | 42482 | 7008 | 64449200 |
Epidural lipomatosis | 55.02 | 13.93 | 21 | 42503 | 856 | 64455352 |
Migraine | 54.77 | 13.93 | 125 | 42399 | 62552 | 64393656 |
Infusion related reaction | 54.61 | 13.93 | 234 | 42290 | 164233 | 64291975 |
Hyperkalaemia | 54.42 | 13.93 | 3 | 42521 | 101126 | 64355082 |
Blood uric acid decreased | 53.69 | 13.93 | 22 | 42502 | 1084 | 64455124 |
C-reactive protein increased | 52.90 | 13.93 | 160 | 42364 | 94749 | 64361459 |
Skin ulcer | 52.87 | 13.93 | 100 | 42424 | 43874 | 64412334 |
pH urine increased | 52.73 | 13.93 | 17 | 42507 | 417 | 64455791 |
Aspartate aminotransferase increased | 52.44 | 13.93 | 186 | 42338 | 119602 | 64336606 |
Protein urine present | 52.31 | 13.93 | 45 | 42479 | 8911 | 64447297 |
Specific gravity urine increased | 52.27 | 13.93 | 17 | 42507 | 429 | 64455779 |
Hyponatraemia | 51.13 | 13.93 | 17 | 42507 | 148322 | 64307886 |
Synovitis | 49.65 | 13.93 | 161 | 42363 | 98929 | 64357279 |
Red blood cell sedimentation rate increased | 49.20 | 13.93 | 80 | 42444 | 31155 | 64425053 |
Arterial occlusive disease | 48.70 | 13.93 | 39 | 42485 | 6994 | 64449214 |
Cardiac failure congestive | 48.58 | 13.93 | 13 | 42511 | 130567 | 64325641 |
Heart rate irregular | 48.42 | 13.93 | 74 | 42450 | 27339 | 64428869 |
Alveolitis | 47.79 | 13.93 | 30 | 42494 | 3662 | 64452546 |
Mean cell haemoglobin decreased | 47.19 | 13.93 | 31 | 42493 | 4091 | 64452117 |
Confusional state | 46.99 | 13.93 | 62 | 42462 | 261082 | 64195126 |
Renal failure | 46.98 | 13.93 | 31 | 42493 | 181657 | 64274551 |
Heart rate decreased | 46.10 | 13.93 | 108 | 42416 | 54959 | 64401249 |
Blood thyroid stimulating hormone increased | 45.81 | 13.93 | 39 | 42485 | 7615 | 64448593 |
Body temperature decreased | 45.81 | 13.93 | 70 | 42454 | 25858 | 64430350 |
Treatment failure | 45.76 | 13.93 | 175 | 42349 | 116641 | 64339567 |
Heart rate increased | 45.59 | 13.93 | 156 | 42368 | 98519 | 64357689 |
Gangrene | 45.17 | 13.93 | 38 | 42486 | 7300 | 64448908 |
Oedema peripheral | 44.26 | 13.93 | 44 | 42480 | 210273 | 64245935 |
Nitrite urine present | 44.25 | 13.93 | 19 | 42505 | 1053 | 64455155 |
Blue toe syndrome | 44.18 | 13.93 | 16 | 42508 | 562 | 64455646 |
Heart sounds | 43.52 | 13.93 | 16 | 42508 | 587 | 64455621 |
Joint injury | 43.46 | 13.93 | 64 | 42460 | 22883 | 64433325 |
Oesophageal pain | 43.46 | 13.93 | 27 | 42497 | 3236 | 64452972 |
Product dose omission issue | 43.02 | 13.93 | 39 | 42485 | 194708 | 64261500 |
Mean cell haemoglobin concentration decreased | 42.89 | 13.93 | 28 | 42496 | 3656 | 64452552 |
Red blood cell count decreased | 42.82 | 13.93 | 97 | 42427 | 48289 | 64407919 |
Blood thyroid stimulating hormone decreased | 42.75 | 13.93 | 32 | 42492 | 5198 | 64451010 |
Band neutrophil percentage increased | 41.80 | 13.93 | 14 | 42510 | 388 | 64455820 |
Cardiac failure | 40.91 | 13.93 | 18 | 42506 | 132355 | 64323853 |
Creatinine urine decreased | 40.82 | 13.93 | 12 | 42512 | 214 | 64455994 |
Paradoxical drug reaction | 40.40 | 13.93 | 33 | 42491 | 6087 | 64450121 |
Disease progression | 39.66 | 13.93 | 22 | 42502 | 141658 | 64314550 |
Haematocrit decreased | 39.18 | 13.93 | 101 | 42423 | 54554 | 64401654 |
Inflammation | 39.15 | 13.93 | 113 | 42411 | 65187 | 64391021 |
Febrile neutropenia | 38.99 | 13.93 | 234 | 42290 | 187423 | 64268785 |
Prolonged expiration | 38.69 | 13.93 | 16 | 42508 | 807 | 64455401 |
Red blood cells urine | 38.61 | 13.93 | 15 | 42509 | 642 | 64455566 |
Band sensation | 38.34 | 13.93 | 15 | 42509 | 654 | 64455554 |
Blood pressure systolic increased | 38.18 | 13.93 | 94 | 42430 | 49359 | 64406849 |
Interstitial lung disease | 37.76 | 13.93 | 9 | 42515 | 97723 | 64358485 |
Arteriovenous fistula occlusion | 37.54 | 13.93 | 14 | 42510 | 535 | 64455673 |
Red blood cell count increased | 36.53 | 13.93 | 25 | 42499 | 3530 | 64452678 |
Gastrointestinal haemorrhage | 36.38 | 13.93 | 21 | 42503 | 132291 | 64323917 |
Blood pressure increased | 36.38 | 13.93 | 216 | 42308 | 172336 | 64283872 |
Intestinal pseudo-obstruction | 35.71 | 13.93 | 20 | 42504 | 1980 | 64454228 |
Stress | 35.57 | 13.93 | 104 | 42420 | 60430 | 64395778 |
Urine leukocyte esterase | 35.32 | 13.93 | 10 | 42514 | 155 | 64456053 |
Band neutrophil count increased | 35.14 | 13.93 | 14 | 42510 | 641 | 64455567 |
Leukocyturia | 34.79 | 13.93 | 18 | 42506 | 1520 | 64454688 |
Platelet transfusion | 34.77 | 13.93 | 19 | 42505 | 1792 | 64454416 |
Cardio-respiratory arrest | 34.39 | 13.93 | 11 | 42513 | 98382 | 64357826 |
Multiple organ dysfunction syndrome | 34.28 | 13.93 | 12 | 42512 | 101401 | 64354807 |
Mean cell haemoglobin increased | 34.05 | 13.93 | 23 | 42501 | 3179 | 64453029 |
Renal impairment | 33.61 | 13.93 | 24 | 42500 | 134993 | 64321215 |
Infusion site extravasation | 33.29 | 13.93 | 31 | 42493 | 6806 | 64449402 |
Inappropriate schedule of product administration | 32.70 | 13.93 | 134 | 42390 | 92152 | 64364056 |
Rhabdomyolysis | 32.51 | 13.93 | 10 | 42514 | 91716 | 64364492 |
Mean cell volume decreased | 32.16 | 13.93 | 23 | 42501 | 3483 | 64452725 |
Throat irritation | 31.68 | 13.93 | 68 | 42456 | 32643 | 64423565 |
Tri-iodothyronine free decreased | 31.41 | 13.93 | 11 | 42513 | 350 | 64455858 |
Respiratory failure | 31.36 | 13.93 | 36 | 42488 | 161147 | 64295061 |
Red blood cell elliptocytes present | 31.35 | 13.93 | 9 | 42515 | 147 | 64456061 |
Transfusion | 30.97 | 13.93 | 48 | 42476 | 17946 | 64438262 |
Product use issue | 30.75 | 13.93 | 188 | 42336 | 151527 | 64304681 |
Respiratory depression | 30.29 | 13.93 | 55 | 42469 | 23388 | 64432820 |
Granuloma | 30.21 | 13.93 | 29 | 42495 | 6612 | 64449596 |
Neutrophil count increased | 29.94 | 13.93 | 57 | 42467 | 25117 | 64431091 |
Vascular malformation | 29.37 | 13.93 | 10 | 42514 | 292 | 64455916 |
Cardiac arrest | 29.34 | 13.93 | 35 | 42489 | 154029 | 64302179 |
Monocyte count increased | 28.93 | 13.93 | 31 | 42493 | 8048 | 64448160 |
Septic shock | 28.61 | 13.93 | 17 | 42507 | 105420 | 64350788 |
Coma | 28.55 | 13.93 | 11 | 42513 | 87604 | 64368604 |
Palpitations | 28.23 | 13.93 | 140 | 42384 | 104348 | 64351860 |
Paranasal cyst | 28.09 | 13.93 | 10 | 42514 | 334 | 64455874 |
Thyroxine free increased | 28.09 | 13.93 | 14 | 42510 | 1093 | 64455115 |
Urine oxalate increased | 27.90 | 13.93 | 9 | 42515 | 221 | 64455987 |
Drug tolerance decreased | 27.11 | 13.93 | 28 | 42496 | 6970 | 64449238 |
CFTR gene mutation | 27.02 | 13.93 | 7 | 42517 | 76 | 64456132 |
Myelocyte count increased | 26.74 | 13.93 | 12 | 42512 | 740 | 64455468 |
Infusion site discomfort | 26.52 | 13.93 | 12 | 42512 | 754 | 64455454 |
Drug dependence | 26.43 | 13.93 | 64 | 42460 | 33248 | 64422960 |
Haematocrit increased | 26.31 | 13.93 | 20 | 42504 | 3325 | 64452883 |
Therapy non-responder | 26.02 | 13.93 | 99 | 42425 | 65800 | 64390408 |
Wound | 25.93 | 13.93 | 9 | 42515 | 76468 | 64379740 |
Neuropathy peripheral | 25.39 | 13.93 | 24 | 42500 | 117501 | 64338707 |
Fatigue | 25.36 | 13.93 | 659 | 41865 | 748071 | 63708137 |
Nasopharyngitis | 25.29 | 13.93 | 218 | 42306 | 195855 | 64260353 |
Rhinorrhoea | 25.27 | 13.93 | 92 | 42432 | 59877 | 64396331 |
Chronic kidney disease | 25.18 | 13.93 | 4 | 42520 | 57915 | 64398293 |
Lactic acidosis | 25.05 | 13.93 | 5 | 42519 | 61405 | 64394803 |
Mental status changes | 24.90 | 13.93 | 5 | 42519 | 61157 | 64395051 |
Thrombocytopenia | 24.69 | 13.93 | 71 | 42453 | 223730 | 64232478 |
Tachycardia | 24.63 | 13.93 | 176 | 42348 | 149403 | 64306805 |
Seizure | 23.96 | 13.93 | 46 | 42478 | 166846 | 64289362 |
Lymphoedema | 23.82 | 13.93 | 31 | 42493 | 9874 | 64446334 |
Injection site extravasation | 23.78 | 13.93 | 28 | 42496 | 8058 | 64448150 |
Abdominal pain | 23.68 | 13.93 | 312 | 42212 | 312063 | 64144145 |
Myelocyte percentage increased | 23.19 | 13.93 | 8 | 42516 | 243 | 64455965 |
Arthritis | 23.13 | 13.93 | 113 | 42411 | 83701 | 64372507 |
Rheumatoid arthritis | 22.95 | 13.93 | 186 | 42338 | 164108 | 64292100 |
Chills | 22.89 | 13.93 | 162 | 42362 | 137102 | 64319106 |
Infusion site scar | 22.77 | 13.93 | 8 | 42516 | 257 | 64455951 |
Poor quality sleep | 22.65 | 13.93 | 43 | 42481 | 18908 | 64437300 |
Gestational hypertension | 22.62 | 13.93 | 14 | 42510 | 1667 | 64454541 |
Crystalluria | 22.46 | 13.93 | 11 | 42513 | 827 | 64455381 |
Cerebrovascular accident | 22.41 | 13.93 | 35 | 42489 | 137548 | 64318660 |
Myocardial reperfusion injury | 22.36 | 13.93 | 5 | 42519 | 27 | 64456181 |
Hypoglycaemia | 22.34 | 13.93 | 16 | 42508 | 89876 | 64366332 |
Pneumonia | 22.21 | 13.93 | 249 | 42275 | 559327 | 63896881 |
Influenza | 22.20 | 13.93 | 133 | 42391 | 106398 | 64349810 |
Cough | 22.16 | 13.93 | 300 | 42224 | 301848 | 64154360 |
Rheumatoid lung | 22.14 | 13.93 | 16 | 42508 | 2463 | 64453745 |
Deep vein thrombosis | 22.12 | 13.93 | 22 | 42502 | 105160 | 64351048 |
Feeling abnormal | 21.88 | 13.93 | 157 | 42367 | 133445 | 64322763 |
Feeling cold | 21.54 | 13.93 | 48 | 42476 | 23630 | 64432578 |
Injection site pain | 21.54 | 13.93 | 25 | 42499 | 111383 | 64344825 |
Angioedema | 21.44 | 13.93 | 7 | 42517 | 61814 | 64394394 |
Dyspepsia | 21.26 | 13.93 | 107 | 42417 | 80205 | 64376003 |
Retinal depigmentation | 21.25 | 13.93 | 8 | 42516 | 314 | 64455894 |
Drug tolerance | 21.18 | 13.93 | 23 | 42501 | 6062 | 64450146 |
Vaginal discharge | 21.17 | 13.93 | 19 | 42505 | 3978 | 64452230 |
Mean cell volume increased | 21.02 | 13.93 | 21 | 42503 | 5025 | 64451183 |
Orthostatic hypotension | 20.84 | 13.93 | 3 | 42521 | 46735 | 64409473 |
Acute myocardial infarction | 20.73 | 13.93 | 10 | 42514 | 69708 | 64386500 |
Coronary artery disease | 20.68 | 13.93 | 7 | 42517 | 60426 | 64395782 |
Gingival bleeding | 20.67 | 13.93 | 36 | 42488 | 14818 | 64441390 |
Diabetes mellitus | 20.59 | 13.93 | 9 | 42515 | 66465 | 64389743 |
Respiration abnormal | 20.48 | 13.93 | 23 | 42501 | 6292 | 64449916 |
Respiratory arrest | 20.22 | 13.93 | 5 | 42519 | 52980 | 64403228 |
Therapeutic response shortened | 20.18 | 13.93 | 29 | 42495 | 10141 | 64446067 |
Pneumonia aspiration | 20.05 | 13.93 | 7 | 42517 | 59264 | 64396944 |
Menstrual disorder | 19.84 | 13.93 | 17 | 42507 | 3348 | 64452860 |
Wrong technique in product usage process | 19.81 | 13.93 | 9 | 42515 | 64965 | 64391243 |
Infusion site swelling | 19.62 | 13.93 | 21 | 42503 | 5444 | 64450764 |
Mastoiditis | 19.36 | 13.93 | 12 | 42512 | 1433 | 64454775 |
Bone marrow failure | 19.35 | 13.93 | 4 | 42520 | 47948 | 64408260 |
Fumbling | 19.18 | 13.93 | 6 | 42518 | 133 | 64456075 |
Cerebral haemorrhage | 19.16 | 13.93 | 5 | 42519 | 51085 | 64405123 |
Creatinine urine increased | 19.11 | 13.93 | 8 | 42516 | 416 | 64455792 |
Suicidal ideation | 19.10 | 13.93 | 10 | 42514 | 66532 | 64389676 |
Urobilinogen urine increased | 19.07 | 13.93 | 9 | 42515 | 623 | 64455585 |
Lipaemic index score | 19.06 | 13.93 | 6 | 42518 | 136 | 64456072 |
Haematuria | 19.03 | 13.93 | 8 | 42516 | 60463 | 64395745 |
Infusion site erythema | 18.90 | 13.93 | 23 | 42501 | 6850 | 64449358 |
Renal pain | 18.63 | 13.93 | 23 | 42501 | 6951 | 64449257 |
Pancreatitis acute | 18.53 | 13.93 | 3 | 42521 | 42852 | 64413356 |
International normalised ratio increased | 18.51 | 13.93 | 15 | 42509 | 79152 | 64377056 |
Thyroid disorder | 18.48 | 13.93 | 30 | 42494 | 11662 | 64444546 |
Aggression | 18.37 | 13.93 | 4 | 42520 | 46228 | 64409980 |
Thyroid stimulating immunoglobulin | 18.27 | 13.93 | 5 | 42519 | 68 | 64456140 |
Limbal swelling | 18.15 | 13.93 | 4 | 42520 | 20 | 64456188 |
Lip pruritus | 18.14 | 13.93 | 9 | 42515 | 696 | 64455512 |
Syncope | 18.12 | 13.93 | 49 | 42475 | 157586 | 64298622 |
Neutrophil percentage decreased | 17.77 | 13.93 | 9 | 42515 | 727 | 64455481 |
Juvenile idiopathic arthritis | 17.76 | 13.93 | 17 | 42507 | 3862 | 64452346 |
Sepsis | 17.59 | 13.93 | 85 | 42439 | 230256 | 64225952 |
Klebsiella test positive | 17.40 | 13.93 | 11 | 42513 | 1359 | 64454849 |
Mean platelet volume decreased | 17.38 | 13.93 | 12 | 42512 | 1719 | 64454489 |
Pulmonary embolism | 17.20 | 13.93 | 45 | 42479 | 146311 | 64309897 |
Suicide attempt | 17.17 | 13.93 | 13 | 42511 | 70994 | 64385214 |
Metabolic acidosis | 17.15 | 13.93 | 13 | 42511 | 70945 | 64385263 |
Hypokalaemia | 17.15 | 13.93 | 34 | 42490 | 121869 | 64334339 |
Endometrial ablation | 17.05 | 13.93 | 9 | 42515 | 792 | 64455416 |
Skin papilloma | 16.96 | 13.93 | 19 | 42505 | 5184 | 64451024 |
Drug abuse | 16.89 | 13.93 | 39 | 42485 | 132335 | 64323873 |
Drug ineffective for unapproved indication | 16.87 | 13.93 | 52 | 42472 | 31081 | 64425127 |
Osteonecrosis of jaw | 16.76 | 13.93 | 3 | 42521 | 39822 | 64416386 |
Peripheral swelling | 16.71 | 13.93 | 211 | 42313 | 208942 | 64247266 |
Vitamin B12 decreased | 16.59 | 13.93 | 14 | 42510 | 2701 | 64453507 |
Hepatic function abnormal | 16.57 | 13.93 | 11 | 42513 | 64302 | 64391906 |
Child abuse | 16.48 | 13.93 | 6 | 42518 | 214 | 64455994 |
Oedema | 16.33 | 13.93 | 22 | 42502 | 91913 | 64364295 |
Rales | 16.31 | 13.93 | 33 | 42491 | 15196 | 64441012 |
Hyperglycaemia | 16.30 | 13.93 | 10 | 42514 | 60958 | 64395250 |
Acute respiratory distress syndrome | 16.24 | 13.93 | 3 | 42521 | 38932 | 64417276 |
Dizziness | 16.10 | 13.93 | 384 | 42140 | 429779 | 64026429 |
Osteoarthritis | 16.10 | 13.93 | 11 | 42513 | 63325 | 64392883 |
Impaired healing | 16.05 | 13.93 | 10 | 42514 | 60463 | 64395745 |
Drug intolerance | 16.03 | 13.93 | 192 | 42332 | 187800 | 64268408 |
Dry throat | 15.76 | 13.93 | 20 | 42504 | 6212 | 64449996 |
Depressive symptom | 15.66 | 13.93 | 17 | 42507 | 4479 | 64451729 |
Sedation | 15.66 | 13.93 | 4 | 42520 | 41458 | 64414750 |
Staphylococcal infection | 15.48 | 13.93 | 7 | 42517 | 50671 | 64405537 |
Swelling | 15.43 | 13.93 | 54 | 42470 | 160164 | 64296044 |
Basophil count increased | 15.43 | 13.93 | 10 | 42514 | 1290 | 64454918 |
General physical health deterioration | 15.39 | 13.93 | 204 | 42320 | 204221 | 64251987 |
Transient ischaemic attack | 15.33 | 13.93 | 5 | 42519 | 44177 | 64412031 |
Appetite disorder | 15.19 | 13.93 | 20 | 42504 | 6441 | 64449767 |
White blood cell count decreased | 15.16 | 13.93 | 165 | 42359 | 157672 | 64298536 |
Infusion site pruritus | 15.03 | 13.93 | 13 | 42511 | 2593 | 64453615 |
Allergic sinusitis | 15.02 | 13.93 | 7 | 42517 | 471 | 64455737 |
Injection site reaction | 14.97 | 13.93 | 6 | 42518 | 46658 | 64409550 |
Immature granulocyte count increased | 14.91 | 13.93 | 7 | 42517 | 479 | 64455729 |
Injection site bruising | 14.75 | 13.93 | 3 | 42521 | 36370 | 64419838 |
Haematoma | 14.75 | 13.93 | 6 | 42518 | 46244 | 64409964 |
Anuria | 14.58 | 13.93 | 36 | 42488 | 18928 | 64437280 |
Change in seizure presentation | 14.54 | 13.93 | 6 | 42518 | 301 | 64455907 |
Serotonin syndrome | 14.43 | 13.93 | 4 | 42520 | 39278 | 64416930 |
COVID-19 | 14.42 | 13.93 | 13 | 42511 | 65127 | 64391081 |
Pericarditis | 14.42 | 13.93 | 12 | 42512 | 62504 | 64393704 |
Cystitis | 14.35 | 13.93 | 61 | 42463 | 42614 | 64413594 |
Infusion site rash | 14.35 | 13.93 | 9 | 42515 | 1097 | 64455111 |
Drug reaction with eosinophilia and systemic symptoms | 14.34 | 13.93 | 9 | 42515 | 54208 | 64402000 |
Immune thrombocytopenia | 14.22 | 13.93 | 31 | 42493 | 15035 | 64441173 |
Drug ineffective | 14.22 | 13.93 | 434 | 42090 | 839813 | 63616395 |
Off label use | 14.18 | 13.93 | 530 | 41994 | 632276 | 63823932 |
Rash | 14.14 | 13.93 | 399 | 42125 | 458150 | 63998058 |
Tinnitus | 14.07 | 13.93 | 52 | 42472 | 34081 | 64422127 |
Aplasia | 14.05 | 13.93 | 20 | 42504 | 6933 | 64449275 |
Bradycardia | 13.97 | 13.93 | 129 | 42395 | 118090 | 64338118 |
Infusion site bruising | 13.94 | 13.93 | 10 | 42514 | 1522 | 64454686 |
None
Source | Code | Description |
---|---|---|
ATC | R06AA11 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Aminoalkyl ethers |
CHEBI has role | CHEBI:37955 | H1 receptor antagonists |
CHEBI has role | CHEBI:50919 | antiemetico |
MeSH PA | D000932 | Antiemetics |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D018494 | Histamine Agents |
MeSH PA | D006633 | Histamine Antagonists |
MeSH PA | D006634 | Histamine H1 Antagonists |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Nausea and vomiting | indication | 16932000 | |
Motion sickness | indication | 37031009 | DOID:2951 |
Vertigo | indication | 399153001 | |
Vomiting | indication | 422400008 | |
Nausea | indication | 422587007 | |
Prevention of Motion Sickness | indication | ||
Prevention of Nausea and Vomiting | indication | ||
Mรฉniรจre's disease | off-label use | 13445001 | DOID:9849 |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Hypophosphatemia | contraindication | 4996001 | |
Alcoholism | contraindication | 7200002 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Low blood pressure | contraindication | 45007003 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Chronic idiopathic constipation | contraindication | 82934008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Liver function tests abnormal | contraindication | 166603001 | |
Arterial hemorrhage | contraindication | 234003006 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Bladder outflow obstruction | contraindication | 236645006 | |
Pyloric obstruction | contraindication | 244815007 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Acute coronary syndrome | contraindication | 394659003 | |
Disorder of coronary artery | contraindication | 414024009 |
None
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Histamine H1 receptor | GPCR | ANTAGONIST | Ki | 7.43 | DRUG MATRIX | CHEMBL | |||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.31 | DRUG MATRIX | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.70 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 6.70 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 5.96 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 6.48 | DRUG MATRIX | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 5.60 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 6.96 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M2 | GPCR | Ki | 6.79 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M3 | GPCR | Ki | 7.02 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M4 | GPCR | Ki | 7.10 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M5 | GPCR | Ki | 6.64 | DRUG MATRIX | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 5.75 | DRUG MATRIX | |||||
Cytochrome P450 2D6 | Enzyme | IC50 | 5.82 | DRUG MATRIX | |||||
Alpha-2A adrenergic receptor | GPCR | Ki | 5.79 | DRUG MATRIX | |||||
Alpha-1D adrenergic receptor | GPCR | Ki | 5.85 | DRUG MATRIX |
ID | Source |
---|---|
4018048 | VUID |
N0000146389 | NUI |
D00520 | KEGG_DRUG |
151666 | RXNORM |
4018048 | VANDF |
C0012381 | UMLSCUI |
CHEBI:4604 | CHEBI |
CHEMBL1200406 | ChEMBL_ID |
DB00985 | DRUGBANK_ID |
D004111 | MESH_DESCRIPTOR_UI |
10660 | PUBCHEM_CID |
61 | INN_ID |
JB937PER5C | UNII |
1568 | MMSL |
4605 | MMSL |
6646 | MMSL |
d00861 | MMSL |
003371 | NDDF |
387469006 | SNOMEDCT_US |
81073007 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Wal-Dram | HUMAN OTC DRUG LABEL | 1 | 0363-0198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Wal-Dram | HUMAN OTC DRUG LABEL | 1 | 0363-0198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Wal-Dram | HUMAN OTC DRUG LABEL | 1 | 0363-0198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Wal-Dram | HUMAN OTC DRUG LABEL | 1 | 0363-0198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 0363-1980 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 0363-1980 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Driminate | HUMAN OTC DRUG LABEL | 1 | 0904-2051 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Driminate | HUMAN OTC DRUG LABEL | 1 | 0904-2051 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Driminate | HUMAN OTC DRUG LABEL | 1 | 0904-2051 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Driminate | HUMAN OTC DRUG LABEL | 1 | 0904-2051 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Dimenhydrinate | HUMAN OTC DRUG LABEL | 1 | 0904-6772 | TABLET | 50 mg | ORAL | OTC monograph final | 16 sections |
PhysiciansCare DimenhydrinateMotion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 0924-1006 | TABLET, COATED | 50 mg | ORAL | OTC monograph final | 16 sections |
Dimenhydrinate | HUMAN OTC DRUG LABEL | 1 | 0924-1007 | TABLET | 50 mg | ORAL | OTC monograph final | 17 sections |
Gravol | HUMAN OTC DRUG LABEL | 1 | 10237-940 | CAPSULE, LIQUID FILLED | 50 mg | ORAL | OTC monograph final | 15 sections |
Gravol | HUMAN OTC DRUG LABEL | 1 | 10237-941 | TABLET, COATED | 50 mg | ORAL | OTC monograph final | 15 sections |
Gravol | HUMAN OTC DRUG LABEL | 1 | 10237-942 | SYRUP | 15 mg | ORAL | OTC monograph final | 15 sections |
Motion Sickness | HUMAN OTC DRUG LABEL | 1 | 11673-198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Motion Sickness | HUMAN OTC DRUG LABEL | 1 | 11673-198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Motion Sickness | HUMAN OTC DRUG LABEL | 1 | 11673-198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Motion Sickness | HUMAN OTC DRUG LABEL | 1 | 11673-198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 11822-0198 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 11822-0198 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Dramamine | HUMAN OTC DRUG LABEL | 1 | 29485-1216 | TABLET, CHEWABLE | 50 mg | ORAL | OTC monograph final | 16 sections |
Dramamine | HUMAN OTC DRUG LABEL | 1 | 29485-6925 | TABLET, CHEWABLE | 50 mg | ORAL | OTC monograph final | 16 sections |
Dramamine | HUMAN OTC DRUG LABEL | 1 | 29485-8048 | TABLET, CHEWABLE | 50 mg | ORAL | OTC monograph final | 16 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 36800-930 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 36800-930 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 46122-536 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 46122-536 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 46122-536 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |