dimenhydrinate ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
N-methylated xanthine derivatives 901 523-87-5

Description:

MoleculeDescription

Synonyms:

  • dimenhydrinate
  • andramine
  • chloranautine
  • diamarin
  • diphenhydramine 8-chlorotheophyllinate
  • diphenhydrinate
  • dramamine
  • menhydrinate
  • theohydramine
A drug combination that contains diphenhydramine and theophylline. It is used for treating VERTIGO, MOTION SICKNESS, and NAUSEA associated with PREGNANCY.
  • Molecular weight: 469.97
  • Formula: C24H28ClN5O3
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.30 g O
0.30 g R

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 31, 1972 FDA ALRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Urine abnormality 431.77 14.80 168 43954 6851 63438049
Lymphocyte count decreased 334.57 14.80 227 43895 30030 63414870
Urine leukocyte esterase positive 275.70 14.80 101 44021 3478 63441422
White blood cells urine positive 210.23 14.80 92 44030 5066 63439834
Red blood cells urine positive 207.13 14.80 79 44043 3047 63441853
Blood urine present 205.56 14.80 129 43993 14940 63429960
Enthesopathy 199.01 14.80 104 44018 8510 63436390
Tongue disorder 181.65 14.80 105 44017 10475 63434425
Urinary sediment present 180.23 14.80 65 44057 2138 63442762
Tenosynovitis 170.56 14.80 111 44011 13684 63431216
Blood parathyroid hormone decreased 162.34 14.80 95 44027 9696 63435204
Aplastic anaemia 159.07 14.80 93 44029 9476 63435424
Urine ketone body present 150.69 14.80 59 44063 2444 63442456
Chest discomfort 150.17 14.80 272 43850 109697 63335203
Panniculitis 149.12 14.80 95 44027 11290 63433610
Flushing 143.32 14.80 216 43906 74871 63370029
Red blood cell sedimentation rate 142.68 14.80 69 44053 4785 63440115
Granuloma skin 137.61 14.80 81 44041 8356 63436544
Urine analysis abnormal 137.55 14.80 68 44054 4948 63439952
Skin necrosis 136.19 14.80 97 44025 13853 63431047
Rheumatoid nodule 122.57 14.80 99 44023 17056 63427844
Death 121.75 14.80 54 44068 374327 63070573
Crystal urine present 121.20 14.80 45 44077 1609 63443291
Red cell distribution width increased 109.28 14.80 76 44046 10448 63434452
Haemoglobin urine present 105.48 14.80 34 44088 789 63444111
Tendonitis 105.10 14.80 96 44026 19519 63425381
Ulcer 104.68 14.80 109 44013 25998 63418902
Culture urine positive 104.13 14.80 51 44071 3636 63441264
Alanine aminotransferase abnormal 102.95 14.80 54 44068 4450 63440450
Neovascularisation 102.04 14.80 36 44086 1109 63443791
Bacterial test positive 100.05 14.80 56 44066 5251 63439649
Febrile neutropenia 96.21 14.80 237 43885 118212 63326688
Fear of injection 86.97 14.80 57 44065 7107 63437793
Specific gravity urine decreased 86.89 14.80 29 44093 753 63444147
Lymphocyte percentage decreased 86.43 14.80 42 44080 2943 63441957
Arterial occlusive disease 86.29 14.80 53 44069 5905 63438995
Gastric disorder 85.18 14.80 117 44005 37252 63407648
Gangrene 84.96 14.80 53 44069 6070 63438830
Oesophageal spasm 84.63 14.80 42 44080 3081 63441819
Hypercalcaemia 83.93 14.80 101 44021 28221 63416679
Bacterial test 82.59 14.80 31 44091 1143 63443757
Hand deformity 81.91 14.80 8 44114 159449 63285451
Nausea 80.06 14.80 925 43197 853546 62591354
Basal cell carcinoma 78.37 14.80 97 44025 27894 63417006
Eosinophil count increased 75.81 14.80 62 44060 10866 63434034
Neutrophil percentage increased 75.10 14.80 38 44084 2905 63441995
Wound 74.62 14.80 12 44110 163251 63281649
Feeling hot 74.39 14.80 129 43993 50225 63394675
Drug ineffective 72.88 14.80 428 43694 1044337 62400563
Eosinophil percentage increased 71.76 14.80 27 44095 1002 63443898
Drug eruption 71.75 14.80 94 44028 28600 63416300
Oesophageal pain 69.62 14.80 39 44083 3662 63441238
Body temperature increased 69.51 14.80 106 44016 37086 63407814
Swelling 68.01 14.80 55 44067 275323 63169577
Monocyte percentage increased 65.39 14.80 26 44096 1122 63443778
Heart sounds 65.37 14.80 25 44097 971 63443929
Blood creatinine decreased 64.60 14.80 43 44079 5502 63439398
Alveolitis 63.93 14.80 34 44088 2881 63442019
Prolonged expiration 63.05 14.80 25 44097 1071 63443829
Rash pruritic 62.21 14.80 132 43990 59667 63385233
Infusion site pain 61.55 14.80 67 44055 16802 63428098
Urticaria 60.64 14.80 252 43870 165550 63279350
Oropharyngeal pain 60.39 14.80 173 43949 94314 63350586
Paradoxical drug reaction 60.29 14.80 37 44085 4115 63440785
Mean cell haemoglobin concentration increased 60.23 14.80 20 44102 511 63444389
C-reactive protein abnormal 57.81 14.80 110 44012 45986 63398914
Completed suicide 57.68 14.80 15 44107 145658 63299242
Toxicity to various agents 56.65 14.80 53 44069 247197 63197703
Insomnia 56.53 14.80 297 43825 214955 63229945
Poor venous access 56.18 14.80 60 44062 14725 63430175
Monocyte count decreased 55.52 14.80 28 44094 2125 63442775
Headache 55.32 14.80 677 43445 632564 62812336
Heart rate increased 54.00 14.80 166 43956 94072 63350828
Myocardial reperfusion injury 53.39 14.80 13 44109 101 63444799
Blood thyroid stimulating hormone increased 52.41 14.80 42 44080 7152 63437748
Angina pectoris 52.40 14.80 83 44039 29995 63414905
Blood uric acid decreased 52.19 14.80 20 44102 781 63444119
Hyponatraemia 51.63 14.80 8 44114 111892 63333008
Granuloma 51.53 14.80 38 44084 5723 63439177
Blood pressure fluctuation 51.40 14.80 105 44017 46212 63398688
Pericarditis 51.24 14.80 14 44108 131565 63313335
Stress 50.94 14.80 131 43991 67036 63377864
Skin ulcer 50.65 14.80 100 44022 42945 63401955
Alanine aminotransferase increased 50.61 14.80 173 43949 103597 63341303
Impaired healing 50.46 14.80 6 44116 102536 63342364
Drug interaction 50.30 14.80 51 44071 229080 63215820
Loss of personal independence in daily activities 49.93 14.80 165 43957 97125 63347775
Intestinal pseudo-obstruction 49.67 14.80 20 44102 892 63444008
Erythema 49.26 14.80 247 43875 175504 63269396
Rhinorrhoea 46.77 14.80 125 43997 65452 63379448
Nitrite urine present 46.66 14.80 20 44102 1046 63443854
Haematocrit decreased 45.82 14.80 91 44031 39249 63405651
Rheumatoid lung 45.21 14.80 30 44092 3818 63441082
Protein urine present 45.16 14.80 36 44086 6084 63438816
Acute kidney injury 44.96 14.80 71 44051 263344 63181556
Cough 43.04 14.80 349 43773 292394 63152506
Neutrophil count increased 42.65 14.80 55 44067 16472 63428428
Red cell distribution width decreased 42.25 14.80 23 44099 2042 63442858
Bradycardia 41.95 14.80 129 43993 73098 63371802
Arteriovenous fistula occlusion 41.89 14.80 14 44108 365 63444535
Oedema peripheral 41.79 14.80 42 44080 189469 63255431
Creatinine urine decreased 41.64 14.80 12 44110 188 63444712
Blood pressure increased 41.41 14.80 222 43900 161840 63283060
Drug tolerance 41.16 14.80 36 44086 6913 63437987
Heart rate decreased 41.09 14.80 95 44027 45465 63399435
pH urine increased 41.08 14.80 14 44108 388 63444512
Body temperature decreased 40.95 14.80 60 44062 20259 63424641
Blue toe syndrome 40.91 14.80 14 44108 393 63444507
Alopecia 39.95 14.80 112 44010 337424 63107476
Cardiac failure congestive 39.61 14.80 8 44114 92425 63352475
Urine leukocyte esterase 39.52 14.80 11 44111 151 63444749
Neurologic neglect syndrome 38.88 14.80 24 44098 2697 63442203
Injection site pain 38.65 14.80 21 44101 129779 63315121
Carotid artery thrombosis 38.30 14.80 24 44098 2770 63442130
Leukocyturia 37.82 14.80 19 44103 1430 63443470
CFTR gene mutation 37.47 14.80 10 44112 116 63444784
Cystitis 37.39 14.80 103 44019 54888 63390012
Lymphoedema 36.79 14.80 43 44079 11649 63433251
Red blood cell sedimentation rate increased 36.72 14.80 89 44033 43893 63401007
Depressive symptom 36.56 14.80 27 44095 4075 63440825
Product dose omission issue 36.44 14.80 67 44055 234246 63210654
Red blood cells urine 36.43 14.80 14 44108 551 63444349
Urinary retention 36.38 14.80 71 44051 30230 63414670
Thrombocytopenia 36.28 14.80 31 44091 151126 63293774
Specific gravity urine increased 36.19 14.80 11 44111 209 63444691
Blood thyroid stimulating hormone decreased 36.02 14.80 28 44094 4562 63440338
Red blood cell count increased 35.93 14.80 24 44098 3088 63441812
Arthropathy 35.75 14.80 68 44054 234724 63210176
Influenza 35.68 14.80 160 43962 108562 63336338
Joint injury 35.15 14.80 69 44053 29503 63415397
Mean cell haemoglobin decreased 35.12 14.80 29 44093 5150 63439750
Anaemia 34.98 14.80 97 44025 293333 63151567
Blood cholesterol increased 34.78 14.80 11 44111 94021 63350879
Red blood cell count decreased 34.74 14.80 83 44039 40562 63404338
Migraine 34.60 14.80 153 43969 103193 63341707
Myelocyte count increased 34.38 14.80 12 44110 358 63444542
Chills 34.36 14.80 163 43959 113215 63331685
Multiple sclerosis relapse 34.15 14.80 92 44030 48386 63396514
Vascular malformation 34.06 14.80 12 44110 368 63444532
Brain death 33.94 14.80 24 44098 3386 63441514
Respiratory tract congestion 33.56 14.80 51 44071 17781 63427119
Thyroxine free increased 33.55 14.80 15 44107 869 63444031
Paranasal cyst 33.26 14.80 12 44110 395 63444505
C-reactive protein increased 33.07 14.80 142 43980 94565 63350335
Confusional state 32.98 14.80 72 44050 236308 63208592
Neuropathy peripheral 32.96 14.80 19 44103 113648 63331252
Blood pressure systolic increased 32.44 14.80 89 44033 47308 63397592
Mean cell haemoglobin increased 32.31 14.80 22 44100 2921 63441979
Tri-iodothyronine free decreased 32.00 14.80 11 44111 313 63444587
Respiration abnormal 31.65 14.80 30 44092 6387 63438513
Irritable bowel syndrome 31.64 14.80 9 44113 82403 63362497
Tachycardia 31.64 14.80 164 43958 117992 63326908
Drug tolerance decreased 31.52 14.80 49 44073 17424 63427476
Gastrointestinal disorder 31.39 14.80 27 44095 131212 63313688
Adjustment disorder 30.78 14.80 22 44100 3156 63441744
Band neutrophil percentage increased 30.78 14.80 10 44112 238 63444662
Blister 30.69 14.80 27 44095 129787 63315113
Band sensation 30.55 14.80 14 44108 859 63444041
Aspartate aminotransferase increased 30.48 14.80 134 43988 90143 63354757
Urine oxalate increased 30.24 14.80 10 44112 252 63444648
Throat irritation 30.18 14.80 75 44047 37572 63407328
Heart rate irregular 29.97 14.80 55 44067 22366 63422534
Drug abuse 29.60 14.80 7 44115 72511 63372389
Crystalluria 29.14 14.80 11 44111 412 63444488
Inappropriate schedule of product administration 29.02 14.80 146 43976 103819 63341081
Osteoarthritis 29.01 14.80 15 44107 95328 63349572
Cardiac failure 28.68 14.80 13 44109 89129 63355771
Affect lability 28.60 14.80 37 44085 11114 63433786
Mean cell haemoglobin concentration decreased 28.27 14.80 22 44100 3590 63441310
Mastoiditis 28.03 14.80 14 44108 1041 63443859
Bulimia nervosa 27.92 14.80 11 44111 463 63444437
Transfusion 27.90 14.80 43 44079 15174 63429726
Disease progression 27.29 14.80 27 44095 122731 63322169
Renal failure 27.18 14.80 25 44097 117627 63327273
Infection 27.12 14.80 76 44046 229097 63215803
Hyperkalaemia 27.09 14.80 3 44119 54200 63390700
Feeling abnormal 26.91 14.80 186 43936 148206 63296694
Appetite disorder 26.57 14.80 29 44093 7292 63437608
Osteomyelitis 26.54 14.80 57 44065 25963 63418937
Rales 26.32 14.80 38 44084 12659 63432241
Band neutrophil count increased 26.23 14.80 10 44112 385 63444515
Concussion 25.81 14.80 32 44090 9212 63435688
Dizziness 25.53 14.80 430 43692 429495 63015405
Hepatic enzyme increased 25.52 14.80 65 44057 202263 63242637
Tinnitus 25.48 14.80 68 44054 35560 63409340
Anuria 25.20 14.80 37 44085 12514 63432386
Noninfective encephalitis 25.09 14.80 10 44112 434 63444466
Extrapyramidal disorder 25.01 14.80 38 44084 13246 63431654
Mean cell volume decreased 24.35 14.80 21 44101 3957 63440943
Multiple organ dysfunction syndrome 24.13 14.80 5 44117 56747 63388153
Myelocyte percentage increased 24.03 14.80 8 44114 206 63444694
Gingival bleeding 23.69 14.80 36 44086 12551 63432349
Lip pruritus 23.50 14.80 12 44110 935 63443965
Abdominal pain 23.46 14.80 309 43813 293147 63151753
Vertigo 23.43 14.80 93 44029 59794 63385106
Palpitations 23.26 14.80 146 43976 112624 63332276
Maternal exposure during pregnancy 23.16 14.80 77 44045 219985 63224915
Angioedema 23.12 14.80 3 44119 47962 63396938
Personality disorder 22.82 14.80 24 44098 5787 63439113
Teratoma benign 22.69 14.80 6 44116 67 63444833
Monocyte count increased 22.65 14.80 27 44095 7466 63437434
Inflammation 22.58 14.80 115 44007 82158 63362742
Discomfort 22.50 14.80 52 44070 167322 63277578
Immune thrombocytopenia 22.48 14.80 32 44090 10524 63434376
Therapeutic response shortened 22.37 14.80 34 44088 11854 63433046
Mean cell volume increased 22.25 14.80 19 44103 3532 63441368
Injection site extravasation 22.15 14.80 29 44093 8812 63436088
Renal pain 21.99 14.80 25 44097 6574 63438326
Musculoskeletal disorder 21.95 14.80 46 44076 20598 63424302
Poor quality sleep 21.88 14.80 45 44077 19890 63425010
Retinal depigmentation 21.57 14.80 8 44114 285 63444615
Chronic kidney disease 21.50 14.80 3 44119 45395 63399505
Urobilinogen urine increased 21.34 14.80 8 44114 294 63444606
Coma 21.31 14.80 9 44113 64355 63380545
Thyroid disorder 21.29 14.80 38 44084 15124 63429776
Infusion site discomfort 21.29 14.80 13 44109 1433 63443467
Pain 20.86 14.80 376 43746 740252 62704648
Nasopharyngitis 20.85 14.80 269 43853 253988 63190912
Knee arthroplasty 20.66 14.80 6 44116 54200 63390700
Rhabdomyolysis 20.59 14.80 3 44119 43948 63400952
Hypoglycaemia 20.54 14.80 8 44114 60057 63384843
Seizure 20.54 14.80 38 44084 132596 63312304
Infusion site scar 20.23 14.80 9 44113 515 63444385
Vision blurred 20.21 14.80 121 44001 91803 63353097
Productive cough 19.97 14.80 92 44030 63116 63381784
Interstitial lung disease 19.96 14.80 9 44113 61899 63383001
Infusion site extravasation 19.88 14.80 30 44092 10396 63434504
Gestational hypertension 19.52 14.80 15 44107 2402 63442498
Breast cancer 19.10 14.80 5 44117 48378 63396522
Gastrointestinal haemorrhage 19.04 14.80 17 44105 81159 63363741
Thyroid cyst 18.97 14.80 9 44113 598 63444302
Allergic sinusitis 18.90 14.80 11 44111 1111 63443789
Immature granulocyte count increased 18.82 14.80 8 44114 410 63444490
Anxiety 18.61 14.80 232 43890 217309 63227591
Drug ineffective for unapproved indication 18.57 14.80 59 44063 34004 63410896
Fumbling 18.42 14.80 6 44116 144 63444756
Adverse drug reaction 18.33 14.80 17 44105 79697 63365203
Klebsiella test positive 18.32 14.80 11 44111 1176 63443724
Thyroid stimulating immunoglobulin 18.28 14.80 5 44117 64 63444836
Pancreatitis relapsing 18.24 14.80 10 44112 900 63444000
Ill-defined disorder 18.14 14.80 18 44104 81737 63363163
Septic shock 18.11 14.80 12 44110 66617 63378283
Limbal swelling 18.11 14.80 4 44118 19 63444881
Deep vein thrombosis 17.97 14.80 19 44103 83781 63361119
Creatinine urine increased 17.92 14.80 7 44115 288 63444612
Suicide attempt 17.92 14.80 10 44112 60908 63383992
Mental status changes 17.88 14.80 3 44119 39596 63405304
Haematocrit increased 17.84 14.80 14 44108 2312 63442588
Endometrial ablation 17.70 14.80 10 44112 954 63443946
Sinus congestion 17.68 14.80 39 44083 18084 63426816
Sneezing 17.55 14.80 39 44083 18179 63426721
Apallic syndrome 17.50 14.80 9 44113 712 63444188
Menstrual disorder 17.49 14.80 20 44102 5293 63439607
Sensory loss 17.48 14.80 28 44094 10210 63434690
Arthritis 17.42 14.80 139 43983 115782 63329118
Hypoxic-ischaemic encephalopathy 17.36 14.80 18 44104 4269 63440631
Metabolic acidosis 17.16 14.80 5 44117 45064 63399836
Lipaemic index score 17.08 14.80 5 44117 83 63444817
Skin papilloma 16.85 14.80 19 44103 4950 63439950
Dry throat 16.66 14.80 22 44100 6743 63438157
Ascites 16.48 14.80 4 44118 40724 63404176
Treatment noncompliance 16.47 14.80 3 44119 37322 63407578
Skin haemorrhage 16.41 14.80 27 44095 10067 63434833
Poor feeding infant 16.39 14.80 7 44115 363 63444537
Hyperhidrosis 16.04 14.80 129 43993 107707 63337193
Blood luteinising hormone decreased 16.01 14.80 4 44118 35 63444865
Multiple sclerosis 15.92 14.80 45 44077 24327 63420573
Hypokalaemia 15.84 14.80 30 44092 103774 63341126
Large intestinal ulcer haemorrhage 15.72 14.80 5 44117 111 63444789
Cyanosis neonatal 15.71 14.80 7 44115 402 63444498
Infusion site swelling 15.70 14.80 26 44096 9744 63435156
Feeling cold 15.50 14.80 44 44078 23844 63421056
Nasal congestion 15.45 14.80 88 44034 65572 63379328
Eating disorder 15.36 14.80 38 44084 18978 63425922
Decerebrate posture 15.27 14.80 5 44117 122 63444778
Hemiplegia 15.24 14.80 25 44097 9298 63435602
Femur fracture 15.23 14.80 5 44117 41751 63403149
Motor dysfunction 15.15 14.80 27 44095 10734 63434166
Basophil count increased 15.11 14.80 9 44113 948 63443952
Lactic acidosis 15.03 14.80 4 44118 38283 63406617
Pollakiuria 14.87 14.80 48 44074 27889 63417011
Urine bilirubin increased 14.86 14.80 4 44118 48 63444852

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Aplastic anaemia 310.69 17.11 121 12586 9595 34934629
Tenosynovitis 160.60 17.11 61 12646 4509 34939715
Enthesopathy 160.05 17.11 61 12646 4552 34939672
Tongue disorder 130.99 17.11 55 12652 5284 34938940
Febrile neutropenia 127.52 17.11 199 12508 136650 34807574
C-reactive protein abnormal 119.80 17.11 60 12647 8650 34935574
Victim of child abuse 114.09 17.11 32 12675 895 34943329
Epidural lipomatosis 110.03 17.11 32 12675 1022 34943202
Respiratory depression 106.68 17.11 69 12638 16176 34928048
Mucosal inflammation 102.86 17.11 96 12611 38526 34905698
Tendonitis 102.79 17.11 55 12652 9085 34935139
Alanine aminotransferase abnormal 97.58 17.11 43 12664 4645 34939579
Synovitis 95.46 17.11 61 12646 14005 34930219
Erythema 93.78 17.11 137 12570 88643 34855581
Drug dependence 86.17 17.11 71 12636 24146 34920078
Red blood cell sedimentation rate 81 17.11 26 12681 1162 34943062
Blood pressure fluctuation 79.51 17.11 69 12638 25180 34919044
Granuloma skin 79.11 17.11 26 12681 1253 34942971
Loss of personal independence in daily activities 77.97 17.11 77 12630 33102 34911122
Juvenile idiopathic arthritis 76.43 17.11 28 12679 1869 34942355
Blood parathyroid hormone decreased 71.53 17.11 25 12682 1455 34942769
Psoriatic arthropathy 68.25 17.11 57 12650 19741 34924483
Panniculitis 67.83 17.11 26 12681 1968 34942256
Platelet transfusion 66.99 17.11 24 12683 1502 34942722
Product prescribing error 64.91 17.11 59 12648 22868 34921356
Nausea 60.78 17.11 264 12443 339644 34604580
Death 59.08 17.11 36 12671 398013 34546211
Rheumatoid nodule 58.02 17.11 26 12681 2921 34941303
Heart rate irregular 57.59 17.11 47 12660 15760 34928464
Product use issue 53.31 17.11 88 12619 63128 34881096
Foetal exposure during pregnancy 49.45 17.11 65 12642 38036 34906188
Child abuse 44.72 17.11 13 12694 414 34943810
Urine abnormality 43.75 17.11 19 12688 1980 34942244
Inappropriate schedule of product administration 43.74 17.11 80 12627 62216 34882008
Lymphocyte percentage decreased 42.58 17.11 19 12688 2113 34942111
Infusion related reaction 42.24 17.11 72 12635 52985 34891239
Alanine aminotransferase increased 41.42 17.11 91 12616 80724 34863500
Aspartate aminotransferase increased 41.36 17.11 82 12625 67701 34876523
Skin necrosis 41.23 17.11 26 12681 5827 34938397
Umbilical hernia 38.63 17.11 23 12684 4654 34939570
Hypercalcaemia 38.37 17.11 37 12670 15431 34928793
Heart rate decreased 37.89 17.11 52 12655 31693 34912531
Treatment failure 36.68 17.11 63 12644 46634 34897590
Perineal infection 35.57 17.11 12 12695 627 34943597
Scrotal infection 35.32 17.11 12 12695 641 34943583
Dermal cyst 35.25 17.11 16 12691 1851 34942373
Tooth injury 34.95 17.11 14 12693 1191 34943033
Optic nerve operation 34.54 17.11 11 12696 479 34943745
Ulcer 33.72 17.11 27 12680 8808 34935416
Off label use 32.77 17.11 262 12445 419262 34524962
Neutrophil percentage increased 32.39 17.11 15 12692 1818 34942406
Infected dermal cyst 31.64 17.11 12 12695 882 34943342
Congenital skin dimples 30.70 17.11 8 12699 168 34944056
Obesity 30.44 17.11 30 12677 12848 34931376
Transfusion 30.16 17.11 25 12682 8560 34935664
C-reactive protein increased 30.09 17.11 63 12644 54035 34890189
Lymphocyte count decreased 28.42 17.11 38 12669 22584 34921640
Contraindicated product administered 28.40 17.11 37 12670 21444 34922780
Anaemia 28.21 17.11 26 12681 233309 34710915
Epispadias 26.38 17.11 7 12700 158 34944066
Arteriovenous fistula 25.76 17.11 11 12696 1100 34943124
pH urine increased 25.72 17.11 6 12701 78 34944146
Tendon pain 25.44 17.11 15 12692 2980 34941244
Vomiting 25.23 17.11 165 12542 247456 34696768
Drug interaction 25.22 17.11 27 12680 225919 34718305
Cholinergic syndrome 24.89 17.11 9 12698 578 34943646
Anal haemorrhage 24.80 17.11 14 12693 2564 34941660
Intentional product use issue 24.77 17.11 62 12645 59754 34884470
Infection 24.75 17.11 81 12626 90834 34853390
Intracranial aneurysm 24.10 17.11 12 12695 1706 34942518
Rheumatoid lung 24.09 17.11 10 12697 932 34943292
Drug intolerance 23.89 17.11 61 12646 59509 34884715
Rheumatoid arthritis 22.99 17.11 46 12661 38192 34906032
Mobility decreased 22.80 17.11 40 12667 30088 34914136
Specific gravity urine increased 22.22 17.11 6 12701 145 34944079
Urine ketone body present 22.19 17.11 10 12697 1138 34943086
Drug hypersensitivity 22.15 17.11 72 12635 80457 34863767
Basal cell carcinoma 21.66 17.11 31 12676 19627 34924597
Headache 21.21 17.11 135 12572 200500 34743724
Toxicity to various agents 21.19 17.11 25 12682 200337 34743887
White blood cells urine positive 21.06 17.11 10 12697 1282 34942942
Completed suicide 20.90 17.11 5 12702 98163 34846061
Blood pressure systolic increased 20.74 17.11 33 12674 22919 34921305
Renal impairment 19.75 17.11 5 12702 94508 34849716
Restrictive cardiomyopathy 19.68 17.11 8 12699 707 34943517
Anal fistula 19.54 17.11 16 12691 5383 34938841
Hyperaesthesia 19.50 17.11 15 12692 4615 34939609
Rash pruritic 19.40 17.11 35 12672 26906 34917318
Blood pressure systolic abnormal 19.33 17.11 14 12693 3934 34940290
Fear of injection 19.32 17.11 10 12697 1542 34942682
Urine leukocyte esterase positive 19.15 17.11 7 12700 464 34943760
Band neutrophil percentage increased 19.14 17.11 5 12702 106 34944118
Hydrothorax 18.67 17.11 7 12700 498 34943726
Cardiac arrest 18.41 17.11 6 12701 96153 34848071
Hypogonadism 18.39 17.11 11 12696 2244 34941980
Pyloric stenosis 18.13 17.11 8 12699 866 34943358
Congenital umbilical hernia 18.08 17.11 6 12701 298 34943926
Hepatic enzyme increased 17.77 17.11 42 12665 39038 34905186
Red blood cell elliptocytes present 17.68 17.11 5 12702 144 34944080
Blood pressure diastolic decreased 17.54 17.11 19 12688 9075 34935149
Aplasia 17.46 17.11 14 12693 4574 34939650
Hypersensitivity 17.16 17.11 55 12652 60980 34883244
Drug eruption 17.15 17.11 28 12679 19870 34924354

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Urine abnormality 471.50 13.72 186 54134 8033 79682035
Aplastic anaemia 405.92 13.72 212 54108 17693 79672375
Enthesopathy 335.34 13.72 162 54158 11446 79678622
Lymphocyte count decreased 324.06 13.72 264 54056 47025 79643043
Tenosynovitis 309.87 13.72 169 54151 15385 79674683
Tongue disorder 298.40 13.72 159 54161 13816 79676252
Urine leukocyte esterase positive 286.22 13.72 107 54213 3984 79686084
White blood cells urine positive 229.11 13.72 102 54218 5973 79684095
Blood parathyroid hormone decreased 225.29 13.72 120 54200 10416 79679652
Red blood cell sedimentation rate 214.89 13.72 95 54225 5470 79684598
Panniculitis 209.93 13.72 121 54199 12250 79677818
Granuloma skin 203.26 13.72 107 54213 9067 79681001
Tendonitis 199.94 13.72 150 54170 23680 79666388
Death 193.93 13.72 72 54248 566442 79123626
Red blood cells urine positive 189.31 13.72 84 54236 4879 79685189
Blood urine present 185.26 13.72 137 54183 21160 79668908
Rheumatoid nodule 178.84 13.72 124 54196 17314 79672754
Alanine aminotransferase abnormal 178.42 13.72 97 54223 8770 79681298
Urinary sediment present 176.23 13.72 66 54254 2469 79687599
Skin necrosis 172.45 13.72 123 54197 17964 79672104
Urine ketone body present 164.40 13.72 69 54251 3496 79686572
Febrile neutropenia 158.30 13.72 428 53892 230571 79459497
Chest discomfort 156.67 13.72 312 54008 137732 79552336
Flushing 141.67 13.72 232 54088 88036 79602032
Nausea 141.65 13.72 1123 53197 956073 78733995
Urine analysis abnormal 141.48 13.72 75 54245 6445 79683623
C-reactive protein abnormal 137.17 13.72 167 54153 48200 79641868
Ulcer 134.91 13.72 132 54188 29840 79660228
Crystal urine present 127.79 13.72 50 54270 2110 79687958
Loss of personal independence in daily activities 122.59 13.72 237 54083 102343 79587725
Lymphocyte percentage decreased 118.72 13.72 61 54259 4915 79685153
Erythema 116.86 13.72 376 53944 222914 79467154
Hypercalcaemia 116.04 13.72 137 54183 38293 79651775
Toxicity to various agents 114.59 13.72 73 54247 421467 79268601
Red cell distribution width increased 112.66 13.72 89 54231 15153 79674915
Drug interaction 111.35 13.72 73 54247 415110 79274958
Fear of injection 110.80 13.72 67 54253 7407 79682661
Basal cell carcinoma 104.27 13.72 128 54192 37247 79652821
Gastric disorder 104.11 13.72 128 54192 37305 79652763
Blood pressure fluctuation 103.04 13.72 173 54147 66972 79623096
Completed suicide 103.01 13.72 21 54299 245746 79444322
Neovascularisation 99.80 13.72 36 54284 1209 79688859
Headache 99.61 13.72 773 53547 652999 79037069
Acute kidney injury 99.24 13.72 125 54195 519279 79170789
Neutrophil percentage increased 99.09 13.72 53 54267 4636 79685432
Culture urine positive 96.18 13.72 51 54269 4384 79685684
Specific gravity urine decreased 95.96 13.72 32 54288 846 79689222
Victim of child abuse 93.39 13.72 32 54288 921 79689147
Haemoglobin urine present 93.32 13.72 32 54288 923 79689145
Bacterial test positive 93.31 13.72 60 54260 7389 79682679
Bacterial test 92.95 13.72 34 54286 1189 79688879
Oesophageal spasm 90.14 13.72 45 54275 3411 79686657
Epidural lipomatosis 85.46 13.72 32 54288 1196 79688872
Anaemia 84.03 13.72 108 54212 444907 79245161
Eosinophil percentage increased 82.32 13.72 33 54287 1485 79688583
Rash pruritic 81.32 13.72 162 54158 71467 79618601
Drug eruption 79.45 13.72 122 54198 43813 79646255
Feeling hot 77.52 13.72 143 54177 59591 79630477
Eosinophil count increased 76.34 13.72 75 54245 17030 79673038
Oesophageal pain 75.66 13.72 43 54277 4236 79685832
Insomnia 74.07 13.72 347 53973 244823 79445245
Heart rate irregular 74.06 13.72 101 54219 32578 79657490
Urticaria 73.66 13.72 285 54035 184916 79505152
Psoriatic arthropathy 71.84 13.72 162 54158 77837 79612231
Monocyte percentage increased 71.40 13.72 33 54287 2108 79687960
Arterial occlusive disease 70.41 13.72 53 54267 8403 79681665
Poor venous access 69.03 13.72 73 54247 18076 79671992
Hyponatraemia 68.93 13.72 18 54302 177830 79512238
Body temperature increased 68.87 13.72 115 54205 44305 79645763
Rheumatoid lung 67.99 13.72 40 54280 4205 79685863
Alanine aminotransferase increased 67.79 13.72 254 54066 162316 79527752
Skin ulcer 66.98 13.72 127 54193 54023 79636045
Infusion site pain 66.73 13.72 64 54256 14112 79675956
Gangrene 65.51 13.72 52 54268 8912 79681156
Inappropriate schedule of product administration 65.33 13.72 220 54100 133408 79556660
Heart rate decreased 64.71 13.72 146 54174 70170 79619898
Heart sounds 62.98 13.72 24 54296 942 79689126
Oropharyngeal pain 62.52 13.72 190 54130 109163 79580905
Hyperkalaemia 62.10 13.72 4 54316 114394 79575674
Drug tolerance decreased 61.86 13.72 59 54261 12919 79677149
Granuloma 60.35 13.72 48 54272 8249 79681819
Migraine 58.69 13.72 161 54159 87332 79602736
Mean cell haemoglobin concentration increased 57.31 13.72 22 54298 881 79689187
Prolonged expiration 56.60 13.72 24 54296 1247 79688821
Drug tolerance 56.39 13.72 47 54273 8628 79681440
Blood creatinine decreased 56.34 13.72 45 54275 7780 79682288
Multiple sclerosis relapse 56.15 13.72 108 54212 46425 79643643
Monocyte count decreased 56.15 13.72 32 54288 3169 79686899
Cardiac failure 55.72 13.72 18 54302 154824 79535244
Renal failure 54.26 13.72 35 54285 200933 79489135
Cardiac failure congestive 54.06 13.72 15 54305 142387 79547681
Myocardial reperfusion injury 53.65 13.72 13 54307 101 79689967
Alveolitis 53.18 13.72 34 54286 4146 79685922
Aspartate aminotransferase increased 51.59 13.72 209 54111 138432 79551636
pH urine increased 51.50 13.72 17 54303 435 79689633
Specific gravity urine increased 50.99 13.72 17 54303 449 79689619
Heart rate increased 50.62 13.72 189 54131 120535 79569533
Protein urine present 50.16 13.72 47 54273 10065 79680003
Blood uric acid decreased 49.76 13.72 22 54298 1266 79688802
C-reactive protein increased 49.20 13.72 196 54124 128831 79561237
Red blood cell sedimentation rate increased 48.68 13.72 101 54219 45841 79644227
Red cell distribution width decreased 48.66 13.72 25 54295 2013 79688055
Transfusion 48.44 13.72 66 54254 21264 79668804
Infusion related reaction 48.39 13.72 295 54025 229942 79460126
Platelet transfusion 48.17 13.72 26 54294 2316 79687752
Nitrite urine present 47.84 13.72 21 54299 1188 79688880
Oedema peripheral 47.78 13.72 61 54259 252227 79437841
Hand deformity 47.63 13.72 7 54313 103912 79586156
Multiple organ dysfunction syndrome 46.91 13.72 12 54308 120234 79569834
Interstitial lung disease 46.37 13.72 10 54310 112590 79577478
Confusional state 45.12 13.72 93 54227 317904 79372164
Disease progression 44.68 13.72 36 54284 184326 79505742
Joint injury 44.46 13.72 78 54242 31257 79658811
Band neutrophil percentage increased 44.37 13.72 15 54305 414 79689654
Body temperature decreased 44.29 13.72 79 54241 32066 79658002
Blood thyroid stimulating hormone increased 44.13 13.72 43 54277 9665 79680403
Lymphoedema 43.82 13.72 48 54272 12365 79677703
Leukocyturia 43.56 13.72 23 54297 1960 79688108
Respiratory depression 43.45 13.72 72 54248 27558 79662510
Blue toe syndrome 43.32 13.72 16 54304 575 79689493
Renal impairment 43.24 13.72 27 54293 157756 79532312
Paradoxical drug reaction 42.75 13.72 37 54283 7148 79682920
Wound 42.70 13.72 13 54307 116166 79573902
Blood pressure systolic increased 42.69 13.72 121 54199 66865 79623203
Respiratory failure 41.78 13.72 37 54283 180874 79509194
Stress 41.51 13.72 134 54186 79478 79610590
Rhinorrhoea 41.45 13.72 130 54190 75944 79614124
Blood thyroid stimulating hormone decreased 41.43 13.72 33 54287 5683 79684385
Blood pressure increased 39.57 13.72 263 54057 211097 79478971
Cystitis 39.38 13.72 101 54219 52631 79637437
Band sensation 38.86 13.72 16 54304 772 79689296
Mean cell haemoglobin concentration decreased 38.79 13.72 29 54291 4550 79685518
Influenza 38.76 13.72 183 54137 129423 79560645
Red blood cell count increased 38.69 13.72 28 54292 4180 79685888
Creatinine urine decreased 38.59 13.72 12 54308 252 79689816
Gastrointestinal haemorrhage 38.15 13.72 27 54293 147692 79542376
Product dose omission issue 38.06 13.72 69 54251 247468 79442600
Coma 37.46 13.72 11 54309 100638 79589430
Band neutrophil count increased 37.42 13.72 15 54305 675 79689393
Urine leukocyte esterase 37.39 13.72 11 54309 190 79689878
Arteriovenous fistula occlusion 37.02 13.72 14 54306 538 79689530
Inflammation 37.01 13.72 144 54176 93609 79596459
Red blood cells urine 36.94 13.72 15 54305 698 79689370
Child abuse 36.63 13.72 13 54307 416 79689652
Musculoskeletal disorder 36.59 13.72 58 54262 21390 79668678
Mucosal inflammation 36.53 13.72 124 54196 75456 79614612
Haematocrit decreased 36.41 13.72 108 54212 61204 79628864
Respiration abnormal 36.35 13.72 35 54285 7753 79682315
Drug dependence 35.67 13.72 83 54237 40686 79649382
Juvenile idiopathic arthritis 35.60 13.72 28 54292 4735 79685333
Neurologic neglect syndrome 35.39 13.72 23 54297 2884 79687184
Rhabdomyolysis 35.35 13.72 13 54307 103118 79586950
Mean cell haemoglobin decreased 34.92 13.72 31 54289 6193 79683875
Thrombocytopenia 34.79 13.72 81 54239 265178 79424890
Swelling 34.58 13.72 59 54261 216652 79473416
Carotid artery thrombosis 34.36 13.72 23 54297 3030 79687038
Pericarditis 34.30 13.72 14 54306 104222 79585846
CFTR gene mutation 33.85 13.72 9 54311 105 79689963
Vascular malformation 33.75 13.72 12 54308 386 79689682
Cough 32.80 13.72 388 53932 366401 79323667
Intestinal pseudo-obstruction 32.64 13.72 21 54299 2588 79687480
Palpitations 32.36 13.72 171 54149 126439 79563629
Throat irritation 32.21 13.72 80 54240 40866 79649202
Paranasal cyst 32.19 13.72 12 54308 443 79689625
Red blood cell count decreased 31.99 13.72 99 54221 57414 79632654
Rheumatoid arthritis 31.83 13.72 247 54073 208223 79481845
Mean cell haemoglobin increased 31.62 13.72 25 54295 4260 79685808
Nasopharyngitis 31.44 13.72 287 54033 253594 79436474
Product use issue 31.15 13.72 247 54073 209575 79480493
Osteomyelitis 31.08 13.72 69 54251 32796 79657272
Septic shock 30.99 13.72 23 54297 122778 79567290
Urine oxalate increased 30.94 13.72 10 54310 239 79689829
Angioedema 30.80 13.72 7 54313 76028 79614040
Tri-iodothyronine free decreased 30.50 13.72 11 54309 369 79689699
Lactic acidosis 29.48 13.72 6 54314 70353 79619715
Thyroxine free increased 29.09 13.72 15 54305 1217 79688851
Deep vein thrombosis 28.80 13.72 24 54296 120895 79569173
Respiratory tract congestion 28.73 13.72 50 54270 19904 79670164
Scrotal infection 28.72 13.72 12 54308 601 79689467
Perineal infection 28.67 13.72 13 54307 794 79689274
Arthritis 28.56 13.72 154 54166 114726 79575342
Feeling abnormal 28.52 13.72 196 54124 159003 79531065
Impaired healing 28.48 13.72 12 54308 87643 79602425
Red blood cell elliptocytes present 28.34 13.72 9 54311 203 79689865
Drug ineffective 27.98 13.72 544 53776 1080369 78609699
Blood cholesterol increased 27.95 13.72 11 54309 83709 79606359
Feeling cold 27.94 13.72 61 54259 28668 79661400
Cardio-respiratory arrest 27.80 13.72 20 54300 108490 79581578
Optic nerve operation 27.78 13.72 11 54309 479 79689589
Therapeutic response shortened 27.20 13.72 43 54277 15820 79674248
Infusion site extravasation 27.19 13.72 34 54286 10074 79679994
Chronic kidney disease 26.98 13.72 6 54314 66148 79623920
Seizure 26.95 13.72 55 54265 188779 79501289
Synovitis 26.66 13.72 185 54135 150549 79539519
Crystalluria 26.64 13.72 13 54307 938 79689130
Haematocrit increased 26.52 13.72 22 54298 4012 79686056
Mean cell volume decreased 26.49 13.72 24 54296 4923 79685145
Cardiac arrest 26.41 13.72 48 54272 172048 79518020
Myelocyte count increased 26.10 13.72 12 54308 757 79689311
Injection site pain 26.04 13.72 30 54290 129808 79560260
Neutrophil count increased 25.88 13.72 60 54260 29336 79660732
Type 2 diabetes mellitus 25.82 13.72 4 54316 57118 79632950
Pneumonia aspiration 25.51 13.72 7 54313 66960 79623108
Osteoarthritis 25.24 13.72 14 54306 87295 79602773
Orthostatic hypotension 25.24 13.72 4 54316 56160 79633908
Treatment noncompliance 25.19 13.72 3 54317 52265 79637803
Gastrointestinal disorder 24.76 13.72 28 54292 122177 79567891
Depressive symptom 24.72 13.72 26 54294 6397 79683671
Coronary artery disease 24.65 13.72 7 54313 65467 79624601
Adjustment disorder 24.61 13.72 21 54299 3979 79686089
Sleep apnoea syndrome 24.32 13.72 67 54253 36411 79653657
Acute myocardial infarction 24.30 13.72 11 54309 77025 79613043
Appetite disorder 24.03 13.72 28 54292 7711 79682357
Neuropathy peripheral 23.91 13.72 37 54283 141268 79548800
Treatment failure 23.84 13.72 198 54122 170288 79519780
Gestational hypertension 23.20 13.72 15 54305 1864 79688204
Therapy non-responder 23.12 13.72 124 54196 92181 79597887
Myelocyte percentage increased 22.84 13.72 8 54312 246 79689822
Metabolic acidosis 22.77 13.72 14 54306 82515 79607553
Monocyte count increased 22.73 13.72 32 54288 10629 79679439
Tinnitus 22.54 13.72 74 54246 44259 79645809
Tachycardia 22.52 13.72 202 54118 177566 79512502
Angina pectoris 22.51 13.72 82 54238 51650 79638418
Fatigue 22.43 13.72 808 53512 928919 78761149
Suicidal ideation 22.42 13.72 12 54308 76328 79613740
Menstrual disorder 22.31 13.72 20 54300 4047 79686021
Hepatic function abnormal 22.20 13.72 11 54309 73096 79616972
Aggression 22.08 13.72 4 54316 50954 79639114
Dizziness 22.05 13.72 491 53829 525950 79164118
Diabetes mellitus 22.05 13.72 13 54307 78377 79611691
Infusion site discomfort 22.03 13.72 13 54307 1374 79688694
Mastoiditis 22.02 13.72 14 54306 1690 79688378
Mental status changes 22.02 13.72 9 54311 66950 79623118
Respiratory arrest 21.95 13.72 6 54314 57544 79632524
Abdominal pain 21.93 13.72 380 53940 389189 79300879
Poor quality sleep 21.81 13.72 48 54272 22674 79667394
Suicide attempt 21.62 13.72 15 54305 82917 79607151
Haematuria 21.45 13.72 10 54310 68826 79621242
Hypokalaemia 21.37 13.72 41 54279 143999 79546069
Lip pruritus 21.24 13.72 11 54309 901 79689167
Urobilinogen urine increased 21.14 13.72 10 54310 673 79689395
Sepsis 21.09 13.72 103 54217 269325 79420743
Irritable bowel syndrome 21.07 13.72 8 54312 62233 79627835
Retinal depigmentation 20.92 13.72 8 54312 317 79689751
Sedation 20.58 13.72 5 54315 51890 79638178
Injection site extravasation 20.58 13.72 29 54291 9640 79680428
Oedema 20.53 13.72 31 54289 119549 79570519
Infected dermal cyst 20.53 13.72 12 54308 1246 79688822
Personality disorder 20.37 13.72 23 54297 6123 79683945
Dermal cyst 20.29 13.72 16 54304 2716 79687352
Cerebral haemorrhage 20.22 13.72 7 54313 57666 79632402
Pleural effusion 20.14 13.72 43 54277 145219 79544849
Brain death 20.12 13.72 22 54298 5655 79684413
Bone marrow failure 20.12 13.72 5 54315 51102 79638966
Acute respiratory distress syndrome 20.12 13.72 3 54317 44064 79646004
Infusion site scar 20.06 13.72 8 54312 355 79689713
International normalised ratio increased 19.95 13.72 17 54303 84704 79605364
Vision blurred 19.93 13.72 132 54188 105766 79584302
Tooth injury 19.81 13.72 14 54306 2014 79688054
Osteonecrosis of jaw 19.60 13.72 3 54317 43223 79646845
Concussion 19.48 13.72 28 54292 9475 79680593
Sneezing 19.37 13.72 42 54278 19641 79670427
Ascites 19.26 13.72 14 54306 75548 79614520
Chills 19.24 13.72 180 54140 160054 79530014
Transient ischaemic attack 19.17 13.72 6 54314 52689 79637379
Multiple sclerosis 19.09 13.72 45 54275 22237 79667831
Drug reaction with eosinophilia and systemic symptoms 19.01 13.72 10 54310 64234 79625834
Noninfective encephalitis 18.94 13.72 9 54311 612 79689456
Allergic sinusitis 18.88 13.72 10 54310 857 79689211
Lipaemic index score 18.86 13.72 6 54314 136 79689932
Fumbling 18.82 13.72 6 54314 137 79689931
Endometrial ablation 18.61 13.72 10 54310 883 79689185
Affect lability 18.59 13.72 30 54290 11229 79678839
Agranulocytosis 18.53 13.72 4 54316 45026 79645042
Wrong technique in product usage process 18.42 13.72 14 54306 73861 79616207
Mean cell volume increased 18.38 13.72 22 54298 6231 79683837
Infusion site pruritus 18.27 13.72 18 54302 4100 79685968
Syncope 18.18 13.72 62 54258 179387 79510681
Thyroid stimulating immunoglobulin 18.10 13.72 5 54315 68 79690000
Limbal swelling 18.02 13.72 4 54316 20 79690048
Hyperglycaemia 17.97 13.72 13 54307 70322 79619746
Rales 17.80 13.72 41 54279 19960 79670108
Blister 17.73 13.72 34 54286 119442 79570626
Abdominal pain upper 17.50 13.72 231 54089 223588 79466480
Gingival bleeding 17.49 13.72 36 54284 16240 79673828
Infusion site swelling 17.44 13.72 24 54296 7802 79682266
Staphylococcal infection 17.36 13.72 9 54311 58286 79631782
Arteriovenous fistula 17.19 13.72 11 54309 1343 79688725
Enterococcus test positive 17.10 13.72 13 54307 2091 79687977
Klebsiella test positive 17.07 13.72 12 54308 1711 79688357
Product prescribing error 17.00 13.72 68 54252 44745 79645323
Cerebral infarction 16.98 13.72 5 54315 45671 79644397
Intentional product use issue 16.85 13.72 168 54152 151944 79538124
Femur fracture 16.82 13.72 3 54317 38649 79651419
Infusion site erythema 16.72 13.72 26 54294 9434 79680634
Creatinine urine increased 16.61 13.72 8 54312 561 79689507
Pneumonia 16.49 13.72 334 53986 659912 79030156
Renal pain 16.36 13.72 24 54296 8272 79681796
Neutrophil percentage decreased 16.28 13.72 9 54311 840 79689228
Foetal heart rate abnormal 16.27 13.72 7 54313 377 79689691
Off label use 16.23 13.72 764 53556 906451 78783617
Thyroid disorder 16.15 13.72 32 54288 14047 79676021
Skin papilloma 16.15 13.72 20 54300 5866 79684202
Anxiety 16.04 13.72 248 54072 248264 79441804
Immature granulocyte count increased 16.00 13.72 8 54312 608 79689460
Blood glucose increased 15.97 13.72 34 54286 114941 79575127
Drug abuse 15.95 13.72 57 54263 162634 79527434
Muscle spasticity 15.89 13.72 41 54279 21434 79668634
Thyroid cyst 15.88 13.72 7 54313 400 79689668
Vomiting 15.84 13.72 578 53742 665250 79024818
Sinus congestion 15.78 13.72 39 54281 19857 79670211
Blood pressure diastolic abnormal 15.61 13.72 38 54282 19164 79670904
Vaginal odour 15.59 13.72 7 54313 418 79689650
Anuria 15.49 13.72 40 54280 20923 79669145
Apallic syndrome 15.18 13.72 9 54311 959 79689109
Anal fistula 15.04 13.72 21 54299 6923 79683145
Intracranial aneurysm 15.04 13.72 17 54303 4533 79685535
Drug resistance 15.01 13.72 5 54315 42208 79647860
Hypoglycaemia 15.00 13.72 29 54291 101565 79588503
Allergy to arthropod bite 14.97 13.72 6 54314 270 79689798
Pancreatitis relapsing 14.95 13.72 9 54311 987 79689081
Loefgren syndrome 14.82 13.72 5 54315 137 79689931
Adverse drug reaction 14.82 13.72 14 54306 66378 79623690
Dry throat 14.78 13.72 22 54298 7684 79682384
Sinus disorder 14.72 13.72 41 54279 22423 79667645
Blood creatine phosphokinase increased 14.68 13.72 14 54306 66076 79623992
Hypogonadism 14.58 13.72 11 54309 1749 79688319
Aplasia 14.53 13.72 22 54298 7798 79682270
Loss of consciousness 14.45 13.72 62 54258 167881 79522187
Hypomagnesaemia 14.33 13.72 7 54313 46904 79643164
Sensory loss 14.28 13.72 29 54291 12962 79677106
Immune thrombocytopenia 14.23 13.72 35 54285 17770 79672298
Cholinergic syndrome 14.22 13.72 9 54311 1078 79688990
Haematoma 14.20 13.72 9 54311 52186 79637882
Cholestasis 14.15 13.72 9 54311 52100 79637968
Cataract 13.92 13.72 81 54239 62039 79628029
Liver function test abnormal 13.92 13.72 14 54306 64461 79625607
Knee arthroplasty 13.92 13.72 6 54314 43242 79646826
Optic neuritis 13.89 13.72 24 54296 9496 79680572
Malaise 13.85 13.72 434 53886 489435 79200633
Basophil count increased 13.82 13.72 10 54310 1493 79688575
Flank pain 13.78 13.72 37 54283 19807 79670261

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R06AA11 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Aminoalkyl ethers
ATC R06AA61 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Aminoalkyl ethers
CHEBI has role CHEBI:37955 H1 receptor antagonists
CHEBI has role CHEBI:50919 antiemetico
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Nausea and vomiting indication 16932000
Motion sickness indication 37031009 DOID:2951
Vertigo indication 399153001
Vomiting indication 422400008
Nausea indication 422587007
Prevention of Motion Sickness indication
Prevention of Nausea and Vomiting indication
Mรฉniรจre's disease off-label use 13445001 DOID:9849
Ocular hypertension contraindication 4210003 DOID:9282
Hypophosphatemia contraindication 4996001
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Low blood pressure contraindication 45007003
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Chronic idiopathic constipation contraindication 82934008
Gout contraindication 90560007 DOID:13189
Liver function tests abnormal contraindication 166603001
Arterial hemorrhage contraindication 234003006
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Pyloric obstruction contraindication 244815007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Angle-closure glaucoma contraindication 392291006 DOID:13550
Acute coronary syndrome contraindication 394659003
Disorder of coronary artery contraindication 414024009




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST Ki 7.43 DRUG MATRIX CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 5.79 DRUG MATRIX
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.31 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.70 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 6.70 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 5.96 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.48 DRUG MATRIX
Alpha-2B adrenergic receptor GPCR Ki 5.60 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 6.96 DRUG MATRIX
Muscarinic acetylcholine receptor M2 GPCR Ki 6.79 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 7.02 DRUG MATRIX
Muscarinic acetylcholine receptor M4 GPCR Ki 7.10 DRUG MATRIX
Muscarinic acetylcholine receptor M5 GPCR Ki 6.64 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.75 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 5.82 DRUG MATRIX
Alpha-1D adrenergic receptor GPCR Ki 5.85 DRUG MATRIX

External reference:

IDSource
4018048 VUID
N0000146389 NUI
D00520 KEGG_DRUG
151666 RXNORM
4018048 VANDF
C0012381 UMLSCUI
CHEBI:4604 CHEBI
CHEMBL1200406 ChEMBL_ID
DB00985 DRUGBANK_ID
D004111 MESH_DESCRIPTOR_UI
10660 PUBCHEM_CID
61 INN_ID
JB937PER5C UNII
1568 MMSL
4605 MMSL
6646 MMSL
d00861 MMSL
003371 NDDF
387469006 SNOMEDCT_US
81073007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Wal-Dram HUMAN OTC DRUG LABEL 1 0363-0198 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 15 sections
Wal-Dram HUMAN OTC DRUG LABEL 1 0363-0198 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 15 sections
Wal-Dram HUMAN OTC DRUG LABEL 1 0363-0198 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 15 sections
Wal-Dram HUMAN OTC DRUG LABEL 1 0363-0198 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 0363-1980 TABLET 50 mg ORAL OTC monograph final 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 0363-1980 TABLET 50 mg ORAL OTC monograph final 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 0363-1980 TABLET 50 mg ORAL OTC monograph final 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 0363-1980 TABLET 50 mg ORAL OTC monograph final 15 sections
Driminate HUMAN OTC DRUG LABEL 1 0904-2051 TABLET 50 mg ORAL OTC monograph final 15 sections
Driminate HUMAN OTC DRUG LABEL 1 0904-2051 TABLET 50 mg ORAL OTC monograph final 15 sections
Driminate HUMAN OTC DRUG LABEL 1 0904-2051 TABLET 50 mg ORAL OTC monograph final 15 sections
Driminate HUMAN OTC DRUG LABEL 1 0904-2051 TABLET 50 mg ORAL OTC monograph final 15 sections
Driminate HUMAN OTC DRUG LABEL 1 0904-2051 TABLET 50 mg ORAL OTC monograph final 15 sections
Driminate HUMAN OTC DRUG LABEL 1 0904-2051 TABLET 50 mg ORAL OTC monograph final 15 sections
Dimenhydrinate HUMAN OTC DRUG LABEL 1 0904-6772 TABLET 50 mg ORAL OTC monograph final 16 sections
PhysiciansCare DimenhydrinateMotion Sickness Relief HUMAN OTC DRUG LABEL 1 0924-1006 TABLET, COATED 50 mg ORAL OTC monograph final 16 sections
Dimenhydrinate HUMAN OTC DRUG LABEL 1 0924-1007 TABLET 50 mg ORAL OTC monograph final 17 sections
Gravol HUMAN OTC DRUG LABEL 1 10237-940 CAPSULE, LIQUID FILLED 50 mg ORAL OTC monograph final 15 sections
Gravol HUMAN OTC DRUG LABEL 1 10237-941 TABLET, COATED 50 mg ORAL OTC monograph final 15 sections
Gravol HUMAN OTC DRUG LABEL 1 10237-942 SYRUP 15 mg ORAL OTC monograph final 15 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 11673-198 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 15 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 11673-198 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 15 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 11673-198 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 15 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 11673-198 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 15 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 11673-198 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 15 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 11673-198 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 11822-0198 TABLET 50 mg ORAL OTC monograph final 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 11822-0198 TABLET 50 mg ORAL OTC monograph final 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 11822-0198 TABLET 50 mg ORAL OTC monograph final 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 11822-0198 TABLET 50 mg ORAL OTC monograph final 15 sections