dimenhydrinate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
N-methylated xanthine derivatives 901 523-87-5

Description:

MoleculeDescription

Synonyms:

  • dimenhydrinate
  • chloranautine
  • diamarin
  • andramine
  • diphenhydramine 8-chlorotheophyllinate
  • diphenhydrinate
  • dramamine
  • menhydrinate
  • theohydramine
A drug combination that contains diphenhydramine and theophylline. It is used for treating VERTIGO, MOTION SICKNESS, and NAUSEA associated with PREGNANCY.
  • Molecular weight: 469.97
  • Formula: C24H28ClN5O3
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 31, 1972 FDA ALRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intestinal pseudo-obstruction 118.98 48.08 14 125 122 2357824
Delirium 98.37 48.08 19 120 5204 2352742
Vitamin B12 decreased 79.49 48.08 11 128 366 2357580
Nausea 75.31 48.08 29 110 112160 2245786
Alveolitis 69.55 48.08 10 129 438 2357508
Condition aggravated 68.60 48.08 20 119 31959 2325987
Parkinson's disease 65.67 48.08 11 128 1315 2356631
Vertigo 65.13 48.08 15 124 9369 2348577
Urinary retention 60.54 48.08 12 127 3655 2354291
Eye pruritus 58.57 48.08 11 128 2520 2355426
Lacrimation increased 57.34 48.08 11 128 2819 2355127
Hypotension 55.15 48.08 17 122 32419 2325527
Constipation 52.69 48.08 15 124 21614 2336332
Depressed mood 50.67 48.08 11 128 5187 2352759
Fatigue 49.45 48.08 20 119 84853 2273093
Mutism 49.06 48.08 7 132 287 2357659
Dizziness 48.99 48.08 18 121 58647 2299299

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:37955 H1-receptor antagonist
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Nausea and vomiting indication 16932000
Motion sickness indication 37031009 DOID:2951
Vertigo indication 399153001
Vomiting indication 422400008
Nausea indication 422587007
Prevention of Motion Sickness indication
Prevention of Nausea and Vomiting indication
Ménière's disease off-label use 13445001 DOID:9849
Ocular hypertension contraindication 4210003 DOID:9282
Hypophosphatemia contraindication 4996001
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Low blood pressure contraindication 45007003
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Chronic idiopathic constipation contraindication 82934008
Gout contraindication 90560007 DOID:13189
Liver function tests abnormal contraindication 166603001
Arterial hemorrhage contraindication 234003006
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Pyloric obstruction contraindication 244815007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Angle-closure glaucoma contraindication 392291006 DOID:13550
Acute coronary syndrome contraindication 394659003
Disorder of coronary artery contraindication 414024009

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST Ki 7.43 DRUG MATRIX CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.31 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.69 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 6.70 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 5.96 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.48 DRUG MATRIX
Alpha-2B adrenergic receptor GPCR Ki 5.60 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 6.96 DRUG MATRIX
Muscarinic acetylcholine receptor M2 GPCR Ki 6.79 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 7.02 DRUG MATRIX
Muscarinic acetylcholine receptor M4 GPCR Ki 7.10 DRUG MATRIX
Muscarinic acetylcholine receptor M5 GPCR Ki 6.64 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.75 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 5.82 DRUG MATRIX
Alpha-2A adrenergic receptor GPCR Ki 5.79 DRUG MATRIX
Alpha-1D adrenergic receptor GPCR Ki 5.85 DRUG MATRIX

External reference:

IDSource
D004111 MESH_DESCRIPTOR_UI
4018048 VUID
N0000146389 NUI
C0012381 UMLSCUI
D00520 KEGG_DRUG
3444 RXNORM
387469006 SNOMEDCT_US
4605 MMSL
d00861 MMSL
81073007 SNOMEDCT_US
4018048 VANDF
1568 MMSL
003371 NDDF
10660 PUBCHEM_CID
CHEBI:4604 CHEBI
DB00985 DRUGBANK_ID
CHEMBL1200406 ChEMBL_ID
JB937PER5C UNII
61 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Wal-Dram HUMAN OTC DRUG LABEL 1 0363-0198 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 9 sections
Driminate HUMAN OTC DRUG LABEL 1 0904-2051 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 9 sections
Dimenhydrinate HUMAN OTC DRUG LABEL 1 0904-6772 TABLET 50 mg ORAL OTC monograph final 10 sections
PhysiciansCare Dimenhydrinate HUMAN OTC DRUG LABEL 1 0924-1006 TABLET, COATED 50 mg ORAL OTC monograph final 11 sections
Dimenhydrinate HUMAN OTC DRUG LABEL 1 0924-1007 TABLET 50 mg ORAL OTC monograph final 10 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 11673-198 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 9 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 11822-0198 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 9 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 15127-262 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 9 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 24385-004 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 9 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 36800-630 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 9 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 36800-930 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 9 sections
Original Formula Motion Sickness Relief HUMAN OTC DRUG LABEL 1 37205-111 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 8 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 41520-630 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 46122-536 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 9 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 49035-981 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 9 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 49348-070 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 9 sections
DIMENHYDRINATE HUMAN OTC DRUG LABEL 1 49483-352 TABLET, FILM COATED 50 mg ORAL OTC monograph final 11 sections
Airmit Ace HUMAN OTC DRUG LABEL 1 49873-802 TABLET 25 mg ORAL OTC monograph final 7 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 50804-198 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 9 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 50804-630 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 9 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 50844-199 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 9 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 55315-198 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 9 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 55315-630 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 9 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 59779-198 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 9 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 59779-629 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 9 sections
motion sickness HUMAN OTC DRUG LABEL 1 62011-0341 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 9 sections
Dramamine Orange HUMAN OTC DRUG LABEL 1 63029-902 TABLET, CHEWABLE 50 mg ORAL OTC monograph final 9 sections
Dramamine for Kids HUMAN OTC DRUG LABEL 1 63029-904 TABLET, CHEWABLE 25 mg ORAL OTC MONOGRAPH FINAL 9 sections
Dramamine for Kids HUMAN OTC DRUG LABEL 1 63029-910 TABLET, CHEWABLE 25 mg ORAL OTC MONOGRAPH FINAL 9 sections
Dimenhydrinate HUMAN PRESCRIPTION DRUG LABEL 1 63323-366 INJECTION, SOLUTION 50 mg INTRAMUSCULAR ANDA 12 sections