Stem definition | Drug id | CAS RN |
---|---|---|
N-methylated xanthine derivatives | 901 | 523-87-5 |
Molecule | Description |
---|---|
Synonyms:
|
A drug combination that contains diphenhydramine and theophylline. It is used for treating VERTIGO, MOTION SICKNESS, and NAUSEA associated with PREGNANCY.
|
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
May 31, 1972 | FDA | ALRA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Urine abnormality | 398.39 | 15.63 | 149 | 31979 | 6311 | 53310627 |
Lymphocyte count decreased | 319.15 | 15.63 | 203 | 31925 | 27849 | 53289089 |
Urine leukocyte esterase positive | 265.58 | 15.63 | 90 | 32038 | 2846 | 53314092 |
Blood urine present | 194.38 | 15.63 | 113 | 32015 | 13172 | 53303766 |
Red blood cells urine positive | 193.31 | 15.63 | 71 | 32057 | 2853 | 53314085 |
White blood cells urine positive | 186.11 | 15.63 | 78 | 32050 | 4467 | 53312471 |
Urinary sediment present | 166.46 | 15.63 | 58 | 32070 | 1996 | 53314942 |
Enthesopathy | 165.26 | 15.63 | 80 | 32048 | 6431 | 53310507 |
Blood parathyroid hormone decreased | 140.65 | 15.63 | 71 | 32057 | 6247 | 53310691 |
Urine ketone body present | 139.52 | 15.63 | 53 | 32075 | 2341 | 53314597 |
Tongue disorder | 138.66 | 15.63 | 79 | 32049 | 8862 | 53308076 |
Tenosynovitis | 133.49 | 15.63 | 80 | 32048 | 9859 | 53307079 |
Flushing | 131.35 | 15.63 | 186 | 31942 | 70414 | 53246524 |
Urine analysis abnormal | 128.61 | 15.63 | 60 | 32068 | 4440 | 53312498 |
Red blood cell sedimentation rate | 125.24 | 15.63 | 52 | 32076 | 2907 | 53314031 |
Crystal urine present | 125.17 | 15.63 | 43 | 32085 | 1417 | 53315521 |
Panniculitis | 123.75 | 15.63 | 70 | 32058 | 7744 | 53309194 |
Granuloma skin | 117.90 | 15.63 | 59 | 32069 | 5095 | 53311843 |
Red cell distribution width increased | 112.30 | 15.63 | 69 | 32059 | 8891 | 53308047 |
Haemoglobin urine present | 110.44 | 15.63 | 34 | 32094 | 785 | 53316153 |
Skin necrosis | 109.08 | 15.63 | 72 | 32056 | 10500 | 53306438 |
Chest discomfort | 107.11 | 15.63 | 205 | 31923 | 99490 | 53217448 |
Death | 106.64 | 15.63 | 41 | 32087 | 357191 | 52959747 |
Rheumatoid nodule | 101.55 | 15.63 | 72 | 32056 | 11792 | 53305146 |
Aplastic anaemia | 99.02 | 15.63 | 62 | 32066 | 8259 | 53308679 |
Culture urine positive | 93.97 | 15.63 | 45 | 32083 | 3530 | 53313408 |
Nausea | 93.58 | 15.63 | 774 | 31354 | 755317 | 52561621 |
Bacterial test positive | 90.61 | 15.63 | 49 | 32079 | 4964 | 53311974 |
Ulcer | 85.28 | 15.63 | 82 | 32046 | 20537 | 53296401 |
Alanine aminotransferase abnormal | 82.81 | 15.63 | 42 | 32086 | 3731 | 53313207 |
Bacterial test | 81.11 | 15.63 | 30 | 32098 | 1229 | 53315709 |
Eosinophil count increased | 79.20 | 15.63 | 57 | 32071 | 9555 | 53307383 |
Feeling hot | 78.03 | 15.63 | 110 | 32018 | 41434 | 53275504 |
Tendonitis | 76.77 | 15.63 | 71 | 32057 | 16935 | 53300003 |
Lymphocyte percentage decreased | 72.11 | 15.63 | 35 | 32093 | 2828 | 53314110 |
Specific gravity urine decreased | 71.87 | 15.63 | 23 | 32105 | 605 | 53316333 |
Fear of injection | 69.93 | 15.63 | 43 | 32085 | 5546 | 53311392 |
Eosinophil percentage increased | 68.96 | 15.63 | 25 | 32103 | 967 | 53315971 |
C-reactive protein abnormal | 68.17 | 15.63 | 81 | 32047 | 25789 | 53291149 |
Monocyte percentage increased | 66.73 | 15.63 | 25 | 32103 | 1062 | 53315876 |
Blood creatinine decreased | 65.20 | 15.63 | 40 | 32088 | 5138 | 53311800 |
Completed suicide | 64.26 | 15.63 | 5 | 32123 | 138196 | 53178742 |
Hypercalcaemia | 63.77 | 15.63 | 76 | 32052 | 24272 | 53292666 |
Basal cell carcinoma | 62.70 | 15.63 | 74 | 32054 | 23395 | 53293543 |
Mean cell haemoglobin concentration increased | 60.59 | 15.63 | 19 | 32109 | 467 | 53316471 |
Infusion site pain | 60.51 | 15.63 | 53 | 32075 | 11780 | 53305158 |
Body temperature increased | 60.33 | 15.63 | 86 | 32042 | 32713 | 53284225 |
Neutrophil percentage increased | 60.27 | 15.63 | 31 | 32097 | 2835 | 53314103 |
Neovascularisation | 59.16 | 15.63 | 20 | 32108 | 627 | 53316311 |
Blood uric acid decreased | 57.45 | 15.63 | 20 | 32108 | 686 | 53316252 |
Insomnia | 55.95 | 15.63 | 242 | 31886 | 186830 | 53130108 |
Product dose omission issue | 55.44 | 15.63 | 23 | 32105 | 191597 | 53125341 |
Monocyte count decreased | 55.26 | 15.63 | 26 | 32102 | 1960 | 53314978 |
Blood pressure fluctuation | 55.21 | 15.63 | 86 | 32042 | 35384 | 53281554 |
Gangrene | 54.68 | 15.63 | 35 | 32093 | 4842 | 53312096 |
Urticaria | 53.76 | 15.63 | 192 | 31936 | 135693 | 53181245 |
Arterial occlusive disease | 53.57 | 15.63 | 35 | 32093 | 5014 | 53311924 |
Oropharyngeal pain | 53.08 | 15.63 | 137 | 31991 | 81131 | 53235807 |
Intestinal pseudo-obstruction | 51.99 | 15.63 | 19 | 32109 | 752 | 53316186 |
Poor venous access | 51.65 | 15.63 | 45 | 32083 | 9930 | 53307008 |
Loss of personal independence in daily activities | 51.18 | 15.63 | 123 | 32005 | 69692 | 53247246 |
Heart rate increased | 50.94 | 15.63 | 136 | 31992 | 82179 | 53234759 |
Alveolitis | 50.27 | 15.63 | 27 | 32101 | 2697 | 53314241 |
Mean cell haemoglobin decreased | 49.95 | 15.63 | 29 | 32099 | 3368 | 53313570 |
Drug eruption | 49.43 | 15.63 | 68 | 32060 | 25026 | 53291912 |
Haematocrit decreased | 47.95 | 15.63 | 83 | 32045 | 37248 | 53279690 |
Rash pruritic | 47.82 | 15.63 | 98 | 32030 | 49912 | 53267026 |
Red blood cell count decreased | 47.66 | 15.63 | 81 | 32047 | 35822 | 53281116 |
Red cell distribution width decreased | 46.61 | 15.63 | 19 | 32109 | 1013 | 53315925 |
Oesophageal spasm | 46.13 | 15.63 | 25 | 32103 | 2543 | 53314395 |
Blood thyroid stimulating hormone increased | 45.83 | 15.63 | 35 | 32093 | 6417 | 53310521 |
Headache | 45.41 | 15.63 | 508 | 31620 | 536313 | 52780625 |
Protein urine present | 45.37 | 15.63 | 33 | 32095 | 5621 | 53311317 |
Alanine aminotransferase increased | 44.33 | 15.63 | 142 | 31986 | 94953 | 53221985 |
Creatinine urine decreased | 43.40 | 15.63 | 12 | 32116 | 187 | 53316751 |
Arteriovenous fistula occlusion | 43.36 | 15.63 | 14 | 32114 | 379 | 53316559 |
Blue toe syndrome | 42.35 | 15.63 | 14 | 32114 | 409 | 53316529 |
Body temperature decreased | 42.06 | 15.63 | 51 | 32077 | 16576 | 53300362 |
Acute kidney injury | 41.81 | 15.63 | 55 | 32073 | 253813 | 53063125 |
Red blood cell sedimentation rate increased | 40.86 | 15.63 | 66 | 32062 | 27991 | 53288947 |
Red blood cells urine | 40.73 | 15.63 | 14 | 32114 | 462 | 53316476 |
Blood thyroid stimulating hormone decreased | 40.52 | 15.63 | 28 | 32100 | 4399 | 53312539 |
Heart sounds | 39.13 | 15.63 | 14 | 32114 | 521 | 53316417 |
Drug ineffective | 38.93 | 15.63 | 311 | 31817 | 816934 | 52500004 |
Drug interaction | 38.75 | 15.63 | 45 | 32083 | 219284 | 53097654 |
Leukocyturia | 38.73 | 15.63 | 17 | 32111 | 1090 | 53315848 |
Specific gravity urine increased | 38.30 | 15.63 | 11 | 32117 | 198 | 53316740 |
Thrombocytopenia | 37.98 | 15.63 | 18 | 32110 | 138709 | 53178229 |
Urine leukocyte esterase | 37.77 | 15.63 | 10 | 32118 | 131 | 53316807 |
Bradycardia | 37.67 | 15.63 | 111 | 32017 | 70945 | 53245993 |
Skin ulcer | 37.18 | 15.63 | 73 | 32055 | 36046 | 53280892 |
Hyponatraemia | 36.67 | 15.63 | 10 | 32118 | 108597 | 53208341 |
Cardiac failure congestive | 36.51 | 15.63 | 6 | 32122 | 92751 | 53224187 |
Chills | 36.32 | 15.63 | 142 | 31986 | 104706 | 53212232 |
Tachycardia | 36.23 | 15.63 | 145 | 31983 | 108067 | 53208871 |
C-reactive protein increased | 35.94 | 15.63 | 106 | 32022 | 67780 | 53249158 |
Neutrophil count increased | 35.58 | 15.63 | 45 | 32083 | 15265 | 53301673 |
Myelocyte count increased | 35.35 | 15.63 | 12 | 32116 | 381 | 53316557 |
Erythema | 35.23 | 15.63 | 187 | 31941 | 156782 | 53160156 |
Nitrite urine present | 35.16 | 15.63 | 15 | 32113 | 897 | 53316041 |
Multiple sclerosis relapse | 35.01 | 15.63 | 81 | 32047 | 44772 | 53272166 |
Heart rate decreased | 34.84 | 15.63 | 72 | 32056 | 36875 | 53280063 |
Gastric disorder | 34.80 | 15.63 | 64 | 32064 | 30101 | 53286837 |
Oesophageal pain | 34.63 | 15.63 | 22 | 32106 | 3004 | 53313934 |
Red blood cell count increased | 34.38 | 15.63 | 21 | 32107 | 2676 | 53314262 |
Blood pressure increased | 34.06 | 15.63 | 171 | 31957 | 140308 | 53176630 |
Infusion related reaction | 33.79 | 15.63 | 184 | 31944 | 155773 | 53161165 |
Toxicity to various agents | 33.72 | 15.63 | 50 | 32078 | 219548 | 53097390 |
Oedema peripheral | 33.57 | 15.63 | 32 | 32096 | 170755 | 53146183 |
Prolonged expiration | 33.29 | 15.63 | 13 | 32115 | 619 | 53316319 |
Confusional state | 33.07 | 15.63 | 41 | 32087 | 194180 | 53122758 |
Thyroxine free increased | 32.62 | 15.63 | 14 | 32114 | 850 | 53316088 |
Mean cell haemoglobin concentration decreased | 32.35 | 15.63 | 21 | 32107 | 2976 | 53313962 |
Joint injury | 32.20 | 15.63 | 52 | 32076 | 22048 | 53294890 |
Mean cell volume decreased | 31.57 | 15.63 | 20 | 32108 | 2717 | 53314221 |
Blood pressure systolic increased | 31.36 | 15.63 | 67 | 32061 | 35110 | 53281828 |
Tri-iodothyronine free decreased | 31.14 | 15.63 | 10 | 32118 | 266 | 53316672 |
Paradoxical drug reaction | 30.36 | 15.63 | 21 | 32107 | 3304 | 53313634 |
pH urine increased | 30.16 | 15.63 | 10 | 32118 | 295 | 53316643 |
Crystalluria | 30.11 | 15.63 | 11 | 32117 | 435 | 53316503 |
Stress | 30.08 | 15.63 | 89 | 32039 | 56995 | 53259943 |
Swelling | 29.84 | 15.63 | 43 | 32085 | 191062 | 53125876 |
Cerebrovascular accident | 29.79 | 15.63 | 13 | 32115 | 105161 | 53211777 |
Urine oxalate increased | 29.06 | 15.63 | 9 | 32119 | 212 | 53316726 |
Band neutrophil percentage increased | 28.86 | 15.63 | 9 | 32119 | 217 | 53316721 |
Gingival bleeding | 28.32 | 15.63 | 36 | 32092 | 12272 | 53304666 |
Rhinorrhoea | 27.73 | 15.63 | 83 | 32045 | 53495 | 53263443 |
Injection site pain | 27.69 | 15.63 | 17 | 32111 | 113374 | 53203564 |
Injection site extravasation | 27.45 | 15.63 | 28 | 32100 | 7524 | 53309414 |
Inflammation | 27.23 | 15.63 | 86 | 32042 | 57050 | 53259888 |
Psoriatic arthropathy | 27.19 | 15.63 | 77 | 32051 | 48113 | 53268825 |
Myelocyte percentage increased | 26.83 | 15.63 | 8 | 32120 | 165 | 53316773 |
Throat irritation | 26.71 | 15.63 | 59 | 32069 | 31622 | 53285316 |
Wound | 26.44 | 15.63 | 11 | 32117 | 91546 | 53225392 |
Alopecia | 25.90 | 15.63 | 65 | 32063 | 234518 | 53082420 |
Psoriasis | 25.90 | 15.63 | 10 | 32118 | 87079 | 53229859 |
Neuropathy peripheral | 25.86 | 15.63 | 15 | 32113 | 103172 | 53213766 |
Thyroid disorder | 25.76 | 15.63 | 36 | 32092 | 13437 | 53303501 |
Cardiac failure | 25.30 | 15.63 | 10 | 32118 | 85834 | 53231104 |
Band sensation | 24.96 | 15.63 | 11 | 32117 | 712 | 53316226 |
Angina pectoris | 24.79 | 15.63 | 54 | 32074 | 28671 | 53288267 |
Migraine | 24.73 | 15.63 | 105 | 32023 | 80312 | 53236626 |
Renal failure | 24.69 | 15.63 | 21 | 32107 | 118431 | 53198507 |
Band neutrophil count increased | 24.61 | 15.63 | 9 | 32119 | 357 | 53316581 |
Aspartate aminotransferase increased | 24.53 | 15.63 | 108 | 32020 | 83921 | 53233017 |
Bulimia nervosa | 24.46 | 15.63 | 10 | 32118 | 537 | 53316401 |
Monocyte count increased | 24.24 | 15.63 | 23 | 32105 | 5662 | 53311276 |
Urinary retention | 23.99 | 15.63 | 53 | 32075 | 28413 | 53288525 |
Disease progression | 23.90 | 15.63 | 16 | 32112 | 101904 | 53215034 |
Teratoma benign | 23.54 | 15.63 | 6 | 32122 | 67 | 53316871 |
Seizure | 23.47 | 15.63 | 26 | 32102 | 129483 | 53187455 |
Mean cell haemoglobin increased | 23.03 | 15.63 | 15 | 32113 | 2137 | 53314801 |
Retinal depigmentation | 22.94 | 15.63 | 8 | 32120 | 276 | 53316662 |
CFTR gene mutation | 22.71 | 15.63 | 6 | 32122 | 78 | 53316860 |
Hyperkalaemia | 22.52 | 15.63 | 3 | 32125 | 54253 | 53262685 |
Infusion site extravasation | 22.46 | 15.63 | 23 | 32105 | 6209 | 53310729 |
Dizziness | 22.34 | 15.63 | 331 | 31797 | 371928 | 52945010 |
Paranasal cyst | 22.28 | 15.63 | 8 | 32120 | 301 | 53316637 |
Vascular malformation | 22.23 | 15.63 | 8 | 32120 | 303 | 53316635 |
Drug abuse | 22.18 | 15.63 | 6 | 32122 | 65520 | 53251418 |
Renal pain | 21.28 | 15.63 | 22 | 32106 | 6005 | 53310933 |
Creatinine urine increased | 21.22 | 15.63 | 7 | 32121 | 203 | 53316735 |
Injection site erythema | 21.17 | 15.63 | 10 | 32118 | 77239 | 53239699 |
Palpitations | 20.98 | 15.63 | 119 | 32009 | 102229 | 53214709 |
Infusion site discomfort | 20.82 | 15.63 | 10 | 32118 | 789 | 53316149 |
Hypoglycaemia | 20.75 | 15.63 | 5 | 32123 | 59008 | 53257930 |
Cardio-respiratory arrest | 20.62 | 15.63 | 5 | 32123 | 58753 | 53258185 |
Nasopharyngitis | 20.46 | 15.63 | 191 | 31937 | 192104 | 53124834 |
Colitis microscopic | 20.00 | 15.63 | 23 | 32105 | 7071 | 53309867 |
Electrocardiogram QRS complex abnormal | 19.68 | 15.63 | 7 | 32121 | 256 | 53316682 |
Gestational hypertension | 19.59 | 15.63 | 14 | 32114 | 2319 | 53314619 |
Mastoiditis | 19.53 | 15.63 | 10 | 32118 | 906 | 53316032 |
Osteoarthritis | 19.51 | 15.63 | 9 | 32119 | 70477 | 53246461 |
Fumbling | 19.23 | 15.63 | 6 | 32122 | 145 | 53316793 |
Immune thrombocytopenia | 19.22 | 15.63 | 26 | 32102 | 9412 | 53307526 |
Multiple organ dysfunction syndrome | 19.03 | 15.63 | 5 | 32123 | 55672 | 53261266 |
Thyroid stimulating immunoglobulin | 18.99 | 15.63 | 5 | 32123 | 64 | 53316874 |
Skin papilloma | 18.96 | 15.63 | 18 | 32110 | 4433 | 53312505 |
Lipaemic index score | 18.58 | 15.63 | 5 | 32123 | 70 | 53316868 |
Klebsiella test positive | 18.40 | 15.63 | 10 | 32118 | 1023 | 53315915 |
Mean cell volume increased | 18.22 | 15.63 | 15 | 32113 | 3064 | 53313874 |
Productive cough | 18.16 | 15.63 | 75 | 32053 | 56654 | 53260284 |
Vitamin B12 decreased | 18.16 | 15.63 | 15 | 32113 | 3077 | 53313861 |
Impaired healing | 18.08 | 15.63 | 8 | 32120 | 64197 | 53252741 |
Dry throat | 17.96 | 15.63 | 20 | 32108 | 5936 | 53311002 |
Feeling abnormal | 17.86 | 15.63 | 141 | 31987 | 135160 | 53181778 |
Wrong technique in product usage process | 17.67 | 15.63 | 7 | 32121 | 60025 | 53256913 |
Immature granulocyte count increased | 17.64 | 15.63 | 7 | 32121 | 348 | 53316590 |
Lymphoedema | 17.29 | 15.63 | 25 | 32103 | 9628 | 53307310 |
Anaemia | 17.23 | 15.63 | 97 | 32031 | 276621 | 53040317 |
Gastrointestinal haemorrhage | 17.04 | 15.63 | 14 | 32114 | 80316 | 53236622 |
Limbal swelling | 17.01 | 15.63 | 4 | 32124 | 31 | 53316907 |
Interstitial lung disease | 16.99 | 15.63 | 7 | 32121 | 58615 | 53258323 |
Rhabdomyolysis | 16.93 | 15.63 | 3 | 32125 | 43920 | 53273018 |
Endometrial ablation | 16.86 | 15.63 | 9 | 32119 | 888 | 53316050 |
Thyroid cyst | 16.67 | 15.63 | 8 | 32120 | 630 | 53316308 |
Granuloma | 16.65 | 15.63 | 17 | 32111 | 4571 | 53312367 |
White blood cell count decreased | 16.58 | 15.63 | 130 | 31998 | 124345 | 53192593 |
Infusion site scar | 16.58 | 15.63 | 6 | 32122 | 231 | 53316707 |
Blood luteinising hormone decreased | 16.57 | 15.63 | 4 | 32124 | 35 | 53316903 |
Infection | 16.55 | 15.63 | 51 | 32077 | 172154 | 53144784 |
Rales | 16.48 | 15.63 | 26 | 32102 | 10806 | 53306132 |
Anxiety | 16.45 | 15.63 | 186 | 31942 | 196518 | 53120420 |
Intestinal polyp | 16.43 | 15.63 | 10 | 32118 | 1266 | 53315672 |
Cough | 16.40 | 15.63 | 231 | 31897 | 256662 | 53060276 |
Urethral pain | 16.12 | 15.63 | 6 | 32122 | 250 | 53316688 |
Heart rate irregular | 16.11 | 15.63 | 37 | 32091 | 20347 | 53296591 |
Angioedema | 15.95 | 15.63 | 3 | 32125 | 42073 | 53274865 |
Large intestinal ulcer haemorrhage | 15.90 | 15.63 | 5 | 32123 | 124 | 53316814 |
Ill-defined disorder | 15.86 | 15.63 | 5 | 32123 | 49439 | 53267499 |
Hypokalaemia | 15.77 | 15.63 | 21 | 32107 | 96496 | 53220442 |
Deep vein thrombosis | 15.74 | 15.63 | 16 | 32112 | 82897 | 53234041 |
Change in seizure presentation | 15.71 | 15.63 | 6 | 32122 | 269 | 53316669 |
Septic shock | 15.65 | 15.63 | 9 | 32119 | 62220 | 53254718 |
Arthritis | 15.64 | 15.63 | 98 | 32030 | 87200 | 53229738 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Enthesopathy | 152.98 | 18.38 | 51 | 8662 | 3512 | 32501301 |
Tenosynovitis | 149.72 | 18.38 | 51 | 8662 | 3752 | 32501061 |
Aplastic anaemia | 140.17 | 18.38 | 58 | 8655 | 7315 | 32497498 |
C-reactive protein abnormal | 120.81 | 18.38 | 50 | 8663 | 6306 | 32498507 |
Tongue disorder | 117.06 | 18.38 | 45 | 8668 | 4679 | 32500134 |
Victim of child abuse | 99.56 | 18.38 | 26 | 8687 | 757 | 32504056 |
Synovitis | 98.01 | 18.38 | 51 | 8662 | 10827 | 32493986 |
Erythema | 94.91 | 18.38 | 114 | 8599 | 82991 | 32421822 |
Alanine aminotransferase abnormal | 93.74 | 18.38 | 34 | 8679 | 3006 | 32501807 |
Tendonitis | 90.47 | 18.38 | 45 | 8668 | 8690 | 32496123 |
Respiratory depression | 75.61 | 18.38 | 46 | 8667 | 13165 | 32491648 |
Psoriatic arthropathy | 62.98 | 18.38 | 46 | 8667 | 17814 | 32486999 |
Loss of personal independence in daily activities | 62.19 | 18.38 | 54 | 8659 | 26779 | 32478034 |
Epidural lipomatosis | 60.88 | 18.38 | 17 | 8696 | 640 | 32504173 |
Febrile neutropenia | 54.39 | 18.38 | 107 | 8606 | 119459 | 32385354 |
Drug dependence | 53.89 | 18.38 | 47 | 8666 | 23437 | 32481376 |
Aspartate aminotransferase increased | 49.42 | 18.38 | 74 | 8639 | 66355 | 32438458 |
Lymphocyte percentage decreased | 47.70 | 18.38 | 19 | 8694 | 2168 | 32502645 |
Nausea | 47.26 | 18.38 | 190 | 8523 | 320659 | 32184154 |
Urine abnormality | 47.03 | 18.38 | 18 | 8695 | 1847 | 32502966 |
Alanine aminotransferase increased | 46.78 | 18.38 | 79 | 8634 | 78400 | 32426413 |
Platelet transfusion | 44.33 | 18.38 | 15 | 8698 | 1079 | 32503734 |
Death | 42.58 | 18.38 | 25 | 8688 | 382492 | 32122321 |
Heart rate irregular | 42.39 | 18.38 | 33 | 8680 | 14045 | 32490768 |
Red blood cell sedimentation rate | 41.82 | 18.38 | 12 | 8701 | 499 | 32504314 |
Treatment failure | 41.81 | 18.38 | 52 | 8661 | 39111 | 32465702 |
Blood pressure fluctuation | 41.63 | 18.38 | 38 | 8675 | 20097 | 32484716 |
Child abuse | 41.23 | 18.38 | 11 | 8702 | 348 | 32504465 |
Lymphocyte count decreased | 40.08 | 18.38 | 38 | 8675 | 21081 | 32483732 |
Granuloma skin | 39.34 | 18.38 | 12 | 8701 | 618 | 32504195 |
Limb malformation | 37.12 | 18.38 | 11 | 8702 | 513 | 32504300 |
Foetal exposure during pregnancy | 36.55 | 18.38 | 50 | 8663 | 41251 | 32463562 |
Product prescribing error | 36.51 | 18.38 | 35 | 8678 | 19682 | 32485131 |
Blood parathyroid hormone decreased | 36.30 | 18.38 | 12 | 8701 | 803 | 32504010 |
Neutrophil percentage increased | 35.82 | 18.38 | 15 | 8698 | 1944 | 32502869 |
Congenital skin dimples | 33.40 | 18.38 | 8 | 8705 | 162 | 32504651 |
Juvenile idiopathic arthritis | 32.45 | 18.38 | 13 | 8700 | 1505 | 32503308 |
C-reactive protein increased | 32.12 | 18.38 | 51 | 8662 | 48051 | 32456762 |
Mucosal inflammation | 31.91 | 18.38 | 42 | 8671 | 33392 | 32471421 |
Panniculitis | 31.51 | 18.38 | 12 | 8701 | 1214 | 32503599 |
Product use issue | 29.93 | 18.38 | 52 | 8661 | 52725 | 32452088 |
Vomiting | 28.78 | 18.38 | 132 | 8581 | 235425 | 32269388 |
Drug intolerance | 27.84 | 18.38 | 49 | 8664 | 50186 | 32454627 |
Drug hypersensitivity | 27.81 | 18.38 | 61 | 8652 | 73339 | 32431474 |
pH urine increased | 27.76 | 18.38 | 6 | 8707 | 75 | 32504738 |
Epispadias | 27.70 | 18.38 | 7 | 8706 | 178 | 32504635 |
Transfusion | 27.35 | 18.38 | 20 | 8693 | 7748 | 32497065 |
Rheumatoid nodule | 25.25 | 18.38 | 12 | 8701 | 2095 | 32502718 |
Contraindicated product administered | 24.76 | 18.38 | 28 | 8685 | 19048 | 32485765 |
Headache | 24.72 | 18.38 | 111 | 8602 | 196086 | 32308727 |
White blood cells urine positive | 24.21 | 18.38 | 10 | 8703 | 1252 | 32503561 |
Specific gravity urine increased | 24.20 | 18.38 | 6 | 8707 | 141 | 32504672 |
Off label use | 23.40 | 18.38 | 151 | 8562 | 306169 | 32198644 |
Urine leukocyte esterase positive | 22.04 | 18.38 | 7 | 8706 | 412 | 32504401 |
Urine ketone body present | 21.80 | 18.38 | 9 | 8704 | 1125 | 32503688 |
Red blood cell elliptocytes present | 21.64 | 18.38 | 5 | 8708 | 86 | 32504727 |
Pyloric stenosis | 21.13 | 18.38 | 8 | 8705 | 797 | 32504016 |
Inappropriate schedule of product administration | 20.76 | 18.38 | 41 | 8672 | 45784 | 32459029 |
Band neutrophil percentage increased | 20.52 | 18.38 | 5 | 8708 | 109 | 32504704 |
Source | Code | Description |
---|---|---|
ATC | R06AA11 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Aminoalkyl ethers |
CHEBI has role | CHEBI:37955 | H1-receptor blockers |
CHEBI has role | CHEBI:50919 | antiemetico |
MeSH PA | D000932 | Antiemetics |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D018494 | Histamine Agents |
MeSH PA | D006633 | Histamine Antagonists |
MeSH PA | D006634 | Histamine H1 Antagonists |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Nausea and vomiting | indication | 16932000 | |
Motion sickness | indication | 37031009 | DOID:2951 |
Vertigo | indication | 399153001 | |
Vomiting | indication | 422400008 | |
Nausea | indication | 422587007 | |
Prevention of Motion Sickness | indication | ||
Prevention of Nausea and Vomiting | indication | ||
Ménière's disease | off-label use | 13445001 | DOID:9849 |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Hypophosphatemia | contraindication | 4996001 | |
Alcoholism | contraindication | 7200002 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Low blood pressure | contraindication | 45007003 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Chronic idiopathic constipation | contraindication | 82934008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Liver function tests abnormal | contraindication | 166603001 | |
Arterial hemorrhage | contraindication | 234003006 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Bladder outflow obstruction | contraindication | 236645006 | |
Pyloric obstruction | contraindication | 244815007 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Acute coronary syndrome | contraindication | 394659003 | |
Disorder of coronary artery | contraindication | 414024009 |
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Histamine H1 receptor | GPCR | ANTAGONIST | Ki | 7.43 | DRUG MATRIX | CHEMBL | |||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.31 | DRUG MATRIX | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.70 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 6.70 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 5.96 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 6.48 | DRUG MATRIX | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 5.60 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 6.96 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M2 | GPCR | Ki | 6.79 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M3 | GPCR | Ki | 7.02 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M4 | GPCR | Ki | 7.10 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M5 | GPCR | Ki | 6.64 | DRUG MATRIX | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 5.75 | DRUG MATRIX | |||||
Cytochrome P450 2D6 | Enzyme | IC50 | 5.82 | DRUG MATRIX | |||||
Alpha-2A adrenergic receptor | GPCR | Ki | 5.79 | DRUG MATRIX | |||||
Alpha-1D adrenergic receptor | GPCR | Ki | 5.85 | DRUG MATRIX |
ID | Source |
---|---|
4018048 | VUID |
N0000146389 | NUI |
D00520 | KEGG_DRUG |
4018048 | VANDF |
C0012381 | UMLSCUI |
CHEBI:4604 | CHEBI |
CHEMBL1200406 | ChEMBL_ID |
DB00985 | DRUGBANK_ID |
D004111 | MESH_DESCRIPTOR_UI |
10660 | PUBCHEM_CID |
61 | INN_ID |
JB937PER5C | UNII |
151666 | RXNORM |
1568 | MMSL |
4605 | MMSL |
6646 | MMSL |
d00861 | MMSL |
003371 | NDDF |
387469006 | SNOMEDCT_US |
81073007 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Wal-Dram | HUMAN OTC DRUG LABEL | 1 | 0363-0198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Wal-Dram | HUMAN OTC DRUG LABEL | 1 | 0363-0198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 0363-1980 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 0363-1980 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Driminate | HUMAN OTC DRUG LABEL | 1 | 0904-2051 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Driminate | HUMAN OTC DRUG LABEL | 1 | 0904-2051 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Dimenhydrinate | HUMAN OTC DRUG LABEL | 1 | 0904-6772 | TABLET | 50 mg | ORAL | OTC monograph final | 16 sections |
PhysiciansCare DimenhydrinateMotion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 0924-1006 | TABLET, COATED | 50 mg | ORAL | OTC monograph final | 16 sections |
Dimenhydrinate | HUMAN OTC DRUG LABEL | 1 | 0924-1007 | TABLET | 50 mg | ORAL | OTC monograph final | 17 sections |
Motion Sickness | HUMAN OTC DRUG LABEL | 1 | 11673-198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Motion Sickness | HUMAN OTC DRUG LABEL | 1 | 11673-198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 11822-0198 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 11822-0198 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Dramamine | HUMAN OTC DRUG LABEL | 1 | 29485-1216 | TABLET, CHEWABLE | 50 mg | ORAL | OTC monograph final | 16 sections |
Dramamine | HUMAN OTC DRUG LABEL | 1 | 29485-6925 | TABLET, CHEWABLE | 50 mg | ORAL | OTC monograph final | 16 sections |
Dramamine | HUMAN OTC DRUG LABEL | 1 | 29485-8048 | TABLET, CHEWABLE | 50 mg | ORAL | OTC monograph final | 16 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 36800-930 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 36800-930 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 46122-536 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 46122-536 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 49035-981 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 49035-981 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
DIMENHYDRINATE | HUMAN OTC DRUG LABEL | 1 | 49483-352 | TABLET, FILM COATED | 50 mg | ORAL | OTC monograph final | 11 sections |
Airmit Ace | HUMAN OTC DRUG LABEL | 1 | 49873-802 | TABLET | 25 mg | ORAL | OTC monograph final | 12 sections |
Motion Sickness | HUMAN OTC DRUG LABEL | 1 | 50804-198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Motion Sickness | HUMAN OTC DRUG LABEL | 1 | 50804-198 | TABLET | 50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 50844-199 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Motion Sickness Relief | HUMAN OTC DRUG LABEL | 1 | 50844-199 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Motion Sickness | HUMAN OTC DRUG LABEL | 1 | 59779-198 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |
Motion Sickness | HUMAN OTC DRUG LABEL | 1 | 59779-198 | TABLET | 50 mg | ORAL | OTC monograph final | 15 sections |