dimenhydrinate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
N-methylated xanthine derivatives 901 523-87-5

Description:

MoleculeDescription

Synonyms:

  • dimenhydrinate
  • andramine
  • chloranautine
  • diamarin
  • diphenhydramine 8-chlorotheophyllinate
  • diphenhydrinate
  • dramamine
  • menhydrinate
  • theohydramine
A drug combination that contains diphenhydramine and theophylline. It is used for treating VERTIGO, MOTION SICKNESS, and NAUSEA associated with PREGNANCY.
  • Molecular weight: 469.97
  • Formula: C24H28ClN5O3
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 31, 1972 FDA ALRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Urine abnormality 398.39 15.63 149 31979 6311 53310627
Lymphocyte count decreased 319.15 15.63 203 31925 27849 53289089
Urine leukocyte esterase positive 265.58 15.63 90 32038 2846 53314092
Blood urine present 194.38 15.63 113 32015 13172 53303766
Red blood cells urine positive 193.31 15.63 71 32057 2853 53314085
White blood cells urine positive 186.11 15.63 78 32050 4467 53312471
Urinary sediment present 166.46 15.63 58 32070 1996 53314942
Enthesopathy 165.26 15.63 80 32048 6431 53310507
Blood parathyroid hormone decreased 140.65 15.63 71 32057 6247 53310691
Urine ketone body present 139.52 15.63 53 32075 2341 53314597
Tongue disorder 138.66 15.63 79 32049 8862 53308076
Tenosynovitis 133.49 15.63 80 32048 9859 53307079
Flushing 131.35 15.63 186 31942 70414 53246524
Urine analysis abnormal 128.61 15.63 60 32068 4440 53312498
Red blood cell sedimentation rate 125.24 15.63 52 32076 2907 53314031
Crystal urine present 125.17 15.63 43 32085 1417 53315521
Panniculitis 123.75 15.63 70 32058 7744 53309194
Granuloma skin 117.90 15.63 59 32069 5095 53311843
Red cell distribution width increased 112.30 15.63 69 32059 8891 53308047
Haemoglobin urine present 110.44 15.63 34 32094 785 53316153
Skin necrosis 109.08 15.63 72 32056 10500 53306438
Chest discomfort 107.11 15.63 205 31923 99490 53217448
Death 106.64 15.63 41 32087 357191 52959747
Rheumatoid nodule 101.55 15.63 72 32056 11792 53305146
Aplastic anaemia 99.02 15.63 62 32066 8259 53308679
Culture urine positive 93.97 15.63 45 32083 3530 53313408
Nausea 93.58 15.63 774 31354 755317 52561621
Bacterial test positive 90.61 15.63 49 32079 4964 53311974
Ulcer 85.28 15.63 82 32046 20537 53296401
Alanine aminotransferase abnormal 82.81 15.63 42 32086 3731 53313207
Bacterial test 81.11 15.63 30 32098 1229 53315709
Eosinophil count increased 79.20 15.63 57 32071 9555 53307383
Feeling hot 78.03 15.63 110 32018 41434 53275504
Tendonitis 76.77 15.63 71 32057 16935 53300003
Lymphocyte percentage decreased 72.11 15.63 35 32093 2828 53314110
Specific gravity urine decreased 71.87 15.63 23 32105 605 53316333
Fear of injection 69.93 15.63 43 32085 5546 53311392
Eosinophil percentage increased 68.96 15.63 25 32103 967 53315971
C-reactive protein abnormal 68.17 15.63 81 32047 25789 53291149
Monocyte percentage increased 66.73 15.63 25 32103 1062 53315876
Blood creatinine decreased 65.20 15.63 40 32088 5138 53311800
Completed suicide 64.26 15.63 5 32123 138196 53178742
Hypercalcaemia 63.77 15.63 76 32052 24272 53292666
Basal cell carcinoma 62.70 15.63 74 32054 23395 53293543
Mean cell haemoglobin concentration increased 60.59 15.63 19 32109 467 53316471
Infusion site pain 60.51 15.63 53 32075 11780 53305158
Body temperature increased 60.33 15.63 86 32042 32713 53284225
Neutrophil percentage increased 60.27 15.63 31 32097 2835 53314103
Neovascularisation 59.16 15.63 20 32108 627 53316311
Blood uric acid decreased 57.45 15.63 20 32108 686 53316252
Insomnia 55.95 15.63 242 31886 186830 53130108
Product dose omission issue 55.44 15.63 23 32105 191597 53125341
Monocyte count decreased 55.26 15.63 26 32102 1960 53314978
Blood pressure fluctuation 55.21 15.63 86 32042 35384 53281554
Gangrene 54.68 15.63 35 32093 4842 53312096
Urticaria 53.76 15.63 192 31936 135693 53181245
Arterial occlusive disease 53.57 15.63 35 32093 5014 53311924
Oropharyngeal pain 53.08 15.63 137 31991 81131 53235807
Intestinal pseudo-obstruction 51.99 15.63 19 32109 752 53316186
Poor venous access 51.65 15.63 45 32083 9930 53307008
Loss of personal independence in daily activities 51.18 15.63 123 32005 69692 53247246
Heart rate increased 50.94 15.63 136 31992 82179 53234759
Alveolitis 50.27 15.63 27 32101 2697 53314241
Mean cell haemoglobin decreased 49.95 15.63 29 32099 3368 53313570
Drug eruption 49.43 15.63 68 32060 25026 53291912
Haematocrit decreased 47.95 15.63 83 32045 37248 53279690
Rash pruritic 47.82 15.63 98 32030 49912 53267026
Red blood cell count decreased 47.66 15.63 81 32047 35822 53281116
Red cell distribution width decreased 46.61 15.63 19 32109 1013 53315925
Oesophageal spasm 46.13 15.63 25 32103 2543 53314395
Blood thyroid stimulating hormone increased 45.83 15.63 35 32093 6417 53310521
Headache 45.41 15.63 508 31620 536313 52780625
Protein urine present 45.37 15.63 33 32095 5621 53311317
Alanine aminotransferase increased 44.33 15.63 142 31986 94953 53221985
Creatinine urine decreased 43.40 15.63 12 32116 187 53316751
Arteriovenous fistula occlusion 43.36 15.63 14 32114 379 53316559
Blue toe syndrome 42.35 15.63 14 32114 409 53316529
Body temperature decreased 42.06 15.63 51 32077 16576 53300362
Acute kidney injury 41.81 15.63 55 32073 253813 53063125
Red blood cell sedimentation rate increased 40.86 15.63 66 32062 27991 53288947
Red blood cells urine 40.73 15.63 14 32114 462 53316476
Blood thyroid stimulating hormone decreased 40.52 15.63 28 32100 4399 53312539
Heart sounds 39.13 15.63 14 32114 521 53316417
Drug ineffective 38.93 15.63 311 31817 816934 52500004
Drug interaction 38.75 15.63 45 32083 219284 53097654
Leukocyturia 38.73 15.63 17 32111 1090 53315848
Specific gravity urine increased 38.30 15.63 11 32117 198 53316740
Thrombocytopenia 37.98 15.63 18 32110 138709 53178229
Urine leukocyte esterase 37.77 15.63 10 32118 131 53316807
Bradycardia 37.67 15.63 111 32017 70945 53245993
Skin ulcer 37.18 15.63 73 32055 36046 53280892
Hyponatraemia 36.67 15.63 10 32118 108597 53208341
Cardiac failure congestive 36.51 15.63 6 32122 92751 53224187
Chills 36.32 15.63 142 31986 104706 53212232
Tachycardia 36.23 15.63 145 31983 108067 53208871
C-reactive protein increased 35.94 15.63 106 32022 67780 53249158
Neutrophil count increased 35.58 15.63 45 32083 15265 53301673
Myelocyte count increased 35.35 15.63 12 32116 381 53316557
Erythema 35.23 15.63 187 31941 156782 53160156
Nitrite urine present 35.16 15.63 15 32113 897 53316041
Multiple sclerosis relapse 35.01 15.63 81 32047 44772 53272166
Heart rate decreased 34.84 15.63 72 32056 36875 53280063
Gastric disorder 34.80 15.63 64 32064 30101 53286837
Oesophageal pain 34.63 15.63 22 32106 3004 53313934
Red blood cell count increased 34.38 15.63 21 32107 2676 53314262
Blood pressure increased 34.06 15.63 171 31957 140308 53176630
Infusion related reaction 33.79 15.63 184 31944 155773 53161165
Toxicity to various agents 33.72 15.63 50 32078 219548 53097390
Oedema peripheral 33.57 15.63 32 32096 170755 53146183
Prolonged expiration 33.29 15.63 13 32115 619 53316319
Confusional state 33.07 15.63 41 32087 194180 53122758
Thyroxine free increased 32.62 15.63 14 32114 850 53316088
Mean cell haemoglobin concentration decreased 32.35 15.63 21 32107 2976 53313962
Joint injury 32.20 15.63 52 32076 22048 53294890
Mean cell volume decreased 31.57 15.63 20 32108 2717 53314221
Blood pressure systolic increased 31.36 15.63 67 32061 35110 53281828
Tri-iodothyronine free decreased 31.14 15.63 10 32118 266 53316672
Paradoxical drug reaction 30.36 15.63 21 32107 3304 53313634
pH urine increased 30.16 15.63 10 32118 295 53316643
Crystalluria 30.11 15.63 11 32117 435 53316503
Stress 30.08 15.63 89 32039 56995 53259943
Swelling 29.84 15.63 43 32085 191062 53125876
Cerebrovascular accident 29.79 15.63 13 32115 105161 53211777
Urine oxalate increased 29.06 15.63 9 32119 212 53316726
Band neutrophil percentage increased 28.86 15.63 9 32119 217 53316721
Gingival bleeding 28.32 15.63 36 32092 12272 53304666
Rhinorrhoea 27.73 15.63 83 32045 53495 53263443
Injection site pain 27.69 15.63 17 32111 113374 53203564
Injection site extravasation 27.45 15.63 28 32100 7524 53309414
Inflammation 27.23 15.63 86 32042 57050 53259888
Psoriatic arthropathy 27.19 15.63 77 32051 48113 53268825
Myelocyte percentage increased 26.83 15.63 8 32120 165 53316773
Throat irritation 26.71 15.63 59 32069 31622 53285316
Wound 26.44 15.63 11 32117 91546 53225392
Alopecia 25.90 15.63 65 32063 234518 53082420
Psoriasis 25.90 15.63 10 32118 87079 53229859
Neuropathy peripheral 25.86 15.63 15 32113 103172 53213766
Thyroid disorder 25.76 15.63 36 32092 13437 53303501
Cardiac failure 25.30 15.63 10 32118 85834 53231104
Band sensation 24.96 15.63 11 32117 712 53316226
Angina pectoris 24.79 15.63 54 32074 28671 53288267
Migraine 24.73 15.63 105 32023 80312 53236626
Renal failure 24.69 15.63 21 32107 118431 53198507
Band neutrophil count increased 24.61 15.63 9 32119 357 53316581
Aspartate aminotransferase increased 24.53 15.63 108 32020 83921 53233017
Bulimia nervosa 24.46 15.63 10 32118 537 53316401
Monocyte count increased 24.24 15.63 23 32105 5662 53311276
Urinary retention 23.99 15.63 53 32075 28413 53288525
Disease progression 23.90 15.63 16 32112 101904 53215034
Teratoma benign 23.54 15.63 6 32122 67 53316871
Seizure 23.47 15.63 26 32102 129483 53187455
Mean cell haemoglobin increased 23.03 15.63 15 32113 2137 53314801
Retinal depigmentation 22.94 15.63 8 32120 276 53316662
CFTR gene mutation 22.71 15.63 6 32122 78 53316860
Hyperkalaemia 22.52 15.63 3 32125 54253 53262685
Infusion site extravasation 22.46 15.63 23 32105 6209 53310729
Dizziness 22.34 15.63 331 31797 371928 52945010
Paranasal cyst 22.28 15.63 8 32120 301 53316637
Vascular malformation 22.23 15.63 8 32120 303 53316635
Drug abuse 22.18 15.63 6 32122 65520 53251418
Renal pain 21.28 15.63 22 32106 6005 53310933
Creatinine urine increased 21.22 15.63 7 32121 203 53316735
Injection site erythema 21.17 15.63 10 32118 77239 53239699
Palpitations 20.98 15.63 119 32009 102229 53214709
Infusion site discomfort 20.82 15.63 10 32118 789 53316149
Hypoglycaemia 20.75 15.63 5 32123 59008 53257930
Cardio-respiratory arrest 20.62 15.63 5 32123 58753 53258185
Nasopharyngitis 20.46 15.63 191 31937 192104 53124834
Colitis microscopic 20.00 15.63 23 32105 7071 53309867
Electrocardiogram QRS complex abnormal 19.68 15.63 7 32121 256 53316682
Gestational hypertension 19.59 15.63 14 32114 2319 53314619
Mastoiditis 19.53 15.63 10 32118 906 53316032
Osteoarthritis 19.51 15.63 9 32119 70477 53246461
Fumbling 19.23 15.63 6 32122 145 53316793
Immune thrombocytopenia 19.22 15.63 26 32102 9412 53307526
Multiple organ dysfunction syndrome 19.03 15.63 5 32123 55672 53261266
Thyroid stimulating immunoglobulin 18.99 15.63 5 32123 64 53316874
Skin papilloma 18.96 15.63 18 32110 4433 53312505
Lipaemic index score 18.58 15.63 5 32123 70 53316868
Klebsiella test positive 18.40 15.63 10 32118 1023 53315915
Mean cell volume increased 18.22 15.63 15 32113 3064 53313874
Productive cough 18.16 15.63 75 32053 56654 53260284
Vitamin B12 decreased 18.16 15.63 15 32113 3077 53313861
Impaired healing 18.08 15.63 8 32120 64197 53252741
Dry throat 17.96 15.63 20 32108 5936 53311002
Feeling abnormal 17.86 15.63 141 31987 135160 53181778
Wrong technique in product usage process 17.67 15.63 7 32121 60025 53256913
Immature granulocyte count increased 17.64 15.63 7 32121 348 53316590
Lymphoedema 17.29 15.63 25 32103 9628 53307310
Anaemia 17.23 15.63 97 32031 276621 53040317
Gastrointestinal haemorrhage 17.04 15.63 14 32114 80316 53236622
Limbal swelling 17.01 15.63 4 32124 31 53316907
Interstitial lung disease 16.99 15.63 7 32121 58615 53258323
Rhabdomyolysis 16.93 15.63 3 32125 43920 53273018
Endometrial ablation 16.86 15.63 9 32119 888 53316050
Thyroid cyst 16.67 15.63 8 32120 630 53316308
Granuloma 16.65 15.63 17 32111 4571 53312367
White blood cell count decreased 16.58 15.63 130 31998 124345 53192593
Infusion site scar 16.58 15.63 6 32122 231 53316707
Blood luteinising hormone decreased 16.57 15.63 4 32124 35 53316903
Infection 16.55 15.63 51 32077 172154 53144784
Rales 16.48 15.63 26 32102 10806 53306132
Anxiety 16.45 15.63 186 31942 196518 53120420
Intestinal polyp 16.43 15.63 10 32118 1266 53315672
Cough 16.40 15.63 231 31897 256662 53060276
Urethral pain 16.12 15.63 6 32122 250 53316688
Heart rate irregular 16.11 15.63 37 32091 20347 53296591
Angioedema 15.95 15.63 3 32125 42073 53274865
Large intestinal ulcer haemorrhage 15.90 15.63 5 32123 124 53316814
Ill-defined disorder 15.86 15.63 5 32123 49439 53267499
Hypokalaemia 15.77 15.63 21 32107 96496 53220442
Deep vein thrombosis 15.74 15.63 16 32112 82897 53234041
Change in seizure presentation 15.71 15.63 6 32122 269 53316669
Septic shock 15.65 15.63 9 32119 62220 53254718
Arthritis 15.64 15.63 98 32030 87200 53229738

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Enthesopathy 152.98 18.38 51 8662 3512 32501301
Tenosynovitis 149.72 18.38 51 8662 3752 32501061
Aplastic anaemia 140.17 18.38 58 8655 7315 32497498
C-reactive protein abnormal 120.81 18.38 50 8663 6306 32498507
Tongue disorder 117.06 18.38 45 8668 4679 32500134
Victim of child abuse 99.56 18.38 26 8687 757 32504056
Synovitis 98.01 18.38 51 8662 10827 32493986
Erythema 94.91 18.38 114 8599 82991 32421822
Alanine aminotransferase abnormal 93.74 18.38 34 8679 3006 32501807
Tendonitis 90.47 18.38 45 8668 8690 32496123
Respiratory depression 75.61 18.38 46 8667 13165 32491648
Psoriatic arthropathy 62.98 18.38 46 8667 17814 32486999
Loss of personal independence in daily activities 62.19 18.38 54 8659 26779 32478034
Epidural lipomatosis 60.88 18.38 17 8696 640 32504173
Febrile neutropenia 54.39 18.38 107 8606 119459 32385354
Drug dependence 53.89 18.38 47 8666 23437 32481376
Aspartate aminotransferase increased 49.42 18.38 74 8639 66355 32438458
Lymphocyte percentage decreased 47.70 18.38 19 8694 2168 32502645
Nausea 47.26 18.38 190 8523 320659 32184154
Urine abnormality 47.03 18.38 18 8695 1847 32502966
Alanine aminotransferase increased 46.78 18.38 79 8634 78400 32426413
Platelet transfusion 44.33 18.38 15 8698 1079 32503734
Death 42.58 18.38 25 8688 382492 32122321
Heart rate irregular 42.39 18.38 33 8680 14045 32490768
Red blood cell sedimentation rate 41.82 18.38 12 8701 499 32504314
Treatment failure 41.81 18.38 52 8661 39111 32465702
Blood pressure fluctuation 41.63 18.38 38 8675 20097 32484716
Child abuse 41.23 18.38 11 8702 348 32504465
Lymphocyte count decreased 40.08 18.38 38 8675 21081 32483732
Granuloma skin 39.34 18.38 12 8701 618 32504195
Limb malformation 37.12 18.38 11 8702 513 32504300
Foetal exposure during pregnancy 36.55 18.38 50 8663 41251 32463562
Product prescribing error 36.51 18.38 35 8678 19682 32485131
Blood parathyroid hormone decreased 36.30 18.38 12 8701 803 32504010
Neutrophil percentage increased 35.82 18.38 15 8698 1944 32502869
Congenital skin dimples 33.40 18.38 8 8705 162 32504651
Juvenile idiopathic arthritis 32.45 18.38 13 8700 1505 32503308
C-reactive protein increased 32.12 18.38 51 8662 48051 32456762
Mucosal inflammation 31.91 18.38 42 8671 33392 32471421
Panniculitis 31.51 18.38 12 8701 1214 32503599
Product use issue 29.93 18.38 52 8661 52725 32452088
Vomiting 28.78 18.38 132 8581 235425 32269388
Drug intolerance 27.84 18.38 49 8664 50186 32454627
Drug hypersensitivity 27.81 18.38 61 8652 73339 32431474
pH urine increased 27.76 18.38 6 8707 75 32504738
Epispadias 27.70 18.38 7 8706 178 32504635
Transfusion 27.35 18.38 20 8693 7748 32497065
Rheumatoid nodule 25.25 18.38 12 8701 2095 32502718
Contraindicated product administered 24.76 18.38 28 8685 19048 32485765
Headache 24.72 18.38 111 8602 196086 32308727
White blood cells urine positive 24.21 18.38 10 8703 1252 32503561
Specific gravity urine increased 24.20 18.38 6 8707 141 32504672
Off label use 23.40 18.38 151 8562 306169 32198644
Urine leukocyte esterase positive 22.04 18.38 7 8706 412 32504401
Urine ketone body present 21.80 18.38 9 8704 1125 32503688
Red blood cell elliptocytes present 21.64 18.38 5 8708 86 32504727
Pyloric stenosis 21.13 18.38 8 8705 797 32504016
Inappropriate schedule of product administration 20.76 18.38 41 8672 45784 32459029
Band neutrophil percentage increased 20.52 18.38 5 8708 109 32504704

Pharmacologic Action:

SourceCodeDescription
ATC R06AA11 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Aminoalkyl ethers
CHEBI has role CHEBI:37955 H1-receptor blockers
CHEBI has role CHEBI:50919 antiemetico
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Nausea and vomiting indication 16932000
Motion sickness indication 37031009 DOID:2951
Vertigo indication 399153001
Vomiting indication 422400008
Nausea indication 422587007
Prevention of Motion Sickness indication
Prevention of Nausea and Vomiting indication
Ménière's disease off-label use 13445001 DOID:9849
Ocular hypertension contraindication 4210003 DOID:9282
Hypophosphatemia contraindication 4996001
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Low blood pressure contraindication 45007003
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Chronic idiopathic constipation contraindication 82934008
Gout contraindication 90560007 DOID:13189
Liver function tests abnormal contraindication 166603001
Arterial hemorrhage contraindication 234003006
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Pyloric obstruction contraindication 244815007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Angle-closure glaucoma contraindication 392291006 DOID:13550
Acute coronary syndrome contraindication 394659003
Disorder of coronary artery contraindication 414024009

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST Ki 7.43 DRUG MATRIX CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.31 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.70 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 6.70 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 5.96 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.48 DRUG MATRIX
Alpha-2B adrenergic receptor GPCR Ki 5.60 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 6.96 DRUG MATRIX
Muscarinic acetylcholine receptor M2 GPCR Ki 6.79 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 7.02 DRUG MATRIX
Muscarinic acetylcholine receptor M4 GPCR Ki 7.10 DRUG MATRIX
Muscarinic acetylcholine receptor M5 GPCR Ki 6.64 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.75 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 5.82 DRUG MATRIX
Alpha-2A adrenergic receptor GPCR Ki 5.79 DRUG MATRIX
Alpha-1D adrenergic receptor GPCR Ki 5.85 DRUG MATRIX

External reference:

IDSource
4018048 VUID
N0000146389 NUI
D00520 KEGG_DRUG
4018048 VANDF
C0012381 UMLSCUI
CHEBI:4604 CHEBI
CHEMBL1200406 ChEMBL_ID
DB00985 DRUGBANK_ID
D004111 MESH_DESCRIPTOR_UI
10660 PUBCHEM_CID
61 INN_ID
JB937PER5C UNII
151666 RXNORM
1568 MMSL
4605 MMSL
6646 MMSL
d00861 MMSL
003371 NDDF
387469006 SNOMEDCT_US
81073007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Wal-Dram HUMAN OTC DRUG LABEL 1 0363-0198 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 15 sections
Wal-Dram HUMAN OTC DRUG LABEL 1 0363-0198 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 0363-1980 TABLET 50 mg ORAL OTC monograph final 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 0363-1980 TABLET 50 mg ORAL OTC monograph final 15 sections
Driminate HUMAN OTC DRUG LABEL 1 0904-2051 TABLET 50 mg ORAL OTC monograph final 15 sections
Driminate HUMAN OTC DRUG LABEL 1 0904-2051 TABLET 50 mg ORAL OTC monograph final 15 sections
Dimenhydrinate HUMAN OTC DRUG LABEL 1 0904-6772 TABLET 50 mg ORAL OTC monograph final 16 sections
PhysiciansCare DimenhydrinateMotion Sickness Relief HUMAN OTC DRUG LABEL 1 0924-1006 TABLET, COATED 50 mg ORAL OTC monograph final 16 sections
Dimenhydrinate HUMAN OTC DRUG LABEL 1 0924-1007 TABLET 50 mg ORAL OTC monograph final 17 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 11673-198 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 15 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 11673-198 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 11822-0198 TABLET 50 mg ORAL OTC monograph final 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 11822-0198 TABLET 50 mg ORAL OTC monograph final 15 sections
Dramamine HUMAN OTC DRUG LABEL 1 29485-1216 TABLET, CHEWABLE 50 mg ORAL OTC monograph final 16 sections
Dramamine HUMAN OTC DRUG LABEL 1 29485-6925 TABLET, CHEWABLE 50 mg ORAL OTC monograph final 16 sections
Dramamine HUMAN OTC DRUG LABEL 1 29485-8048 TABLET, CHEWABLE 50 mg ORAL OTC monograph final 16 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 36800-930 TABLET 50 mg ORAL OTC monograph final 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 36800-930 TABLET 50 mg ORAL OTC monograph final 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 46122-536 TABLET 50 mg ORAL OTC monograph final 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 46122-536 TABLET 50 mg ORAL OTC monograph final 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 49035-981 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 49035-981 TABLET 50 mg ORAL OTC MONOGRAPH FINAL 15 sections
DIMENHYDRINATE HUMAN OTC DRUG LABEL 1 49483-352 TABLET, FILM COATED 50 mg ORAL OTC monograph final 11 sections
Airmit Ace HUMAN OTC DRUG LABEL 1 49873-802 TABLET 25 mg ORAL OTC monograph final 12 sections
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