dimenhydrinate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
N-methylated xanthine derivatives 901 523-87-5

Description:

MoleculeDescription

Synonyms:

  • dimenhydrinate
  • andramine
  • chloranautine
  • diamarin
  • diphenhydramine 8-chlorotheophyllinate
  • diphenhydrinate
  • dramamine
  • menhydrinate
  • theohydramine
A drug combination that contains diphenhydramine and theophylline. It is used for treating VERTIGO, MOTION SICKNESS, and NAUSEA associated with PREGNANCY.
  • Molecular weight: 469.97
  • Formula: C24H28ClN5O3
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.30 g O
0.30 g R

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
May 31, 1972 FDA ALRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Urine abnormality 453.15 13.98 176 59372 7561 90561338
Gangrene 339.77 13.98 167 59381 12709 90556190
Arterial occlusive disease 339.13 13.98 165 59383 12281 90556618
Lymphocyte count decreased 324.99 13.98 231 59317 34819 90534080
Neurologic neglect syndrome 311.38 13.98 140 59408 8707 90560192
Chest discomfort 309.97 13.98 417 59131 137948 90430951
Carotid artery thrombosis 304.57 13.98 139 59409 8953 90559946
Adjustment disorder 293.67 13.98 138 59410 9504 90559395
Urine leukocyte esterase positive 293.60 13.98 102 59446 3180 90565719
Febrile neutropenia 269.57 13.98 419 59129 157930 90410969
Personality disorder 265.98 13.98 140 59408 12304 90556595
Sensory loss 244.99 13.98 151 59397 17924 90550975
Affect lability 237.48 13.98 148 59400 17915 90550984
Hemiplegia 234.42 13.98 141 59407 16019 90552880
Angina pectoris 232.02 13.98 198 59350 38962 90529937
Skin haemorrhage 226.57 13.98 153 59395 21227 90547672
Sneezing 223.35 13.98 173 59375 29696 90539203
Respiratory tract congestion 220.89 13.98 166 59382 27244 90541655
Blood urine present 220.69 13.98 139 59409 17139 90551760
Motor dysfunction 216.75 13.98 143 59405 19087 90549812
Red blood cells urine positive 212.66 13.98 80 59468 3145 90565754
Sinus congestion 209.78 13.98 161 59387 27263 90541636
Rhinorrhoea 205.07 13.98 271 59277 88045 90480854
Eating disorder 204.27 13.98 160 59388 27913 90540986
White blood cells urine positive 200.97 13.98 94 59454 6404 90562495
Glossodynia 196.03 13.98 3 59545 321776 90247123
Coordination abnormal 193.91 13.98 139 59409 21217 90547682
Sinus disorder 191.57 13.98 168 59380 34279 90534620
Cystitis 187.13 13.98 225 59323 66493 90502406
Urinary sediment present 184.62 13.98 65 59483 2109 90566790
Systemic lupus erythematosus 181.75 13.98 15 59533 361881 90207018
Enthesopathy 179.10 13.98 98 59450 9306 90559593
Muscle spasticity 178.10 13.98 163 59385 35159 90533740
Hemiparesis 174.57 13.98 154 59394 31665 90537234
Tongue disorder 165.95 13.98 98 59450 10762 90558137
Aplastic anaemia 165.09 13.98 105 59443 13164 90555735
Blood pressure increased 163.28 13.98 384 59164 196833 90372066
Flushing 158.68 13.98 240 59308 88251 90480648
Cough 157.22 13.98 566 58982 368396 90200503
Tenosynovitis 153.75 13.98 104 59444 14463 90554436
Urine ketone body present 152.78 13.98 59 59489 2493 90566406
Influenza 145.71 13.98 298 59250 138966 90429933
Hand deformity 144.15 13.98 14 59534 296348 90272551
Urine analysis abnormal 141.56 13.98 69 59479 5152 90563747
Palpitations 141.20 13.98 291 59257 136437 90432462
Neovascularisation 139.43 13.98 49 59499 1581 90567318
Nausea 138.91 13.98 1220 58328 1109096 89459803
Wound 138.09 13.98 18 59530 302962 90265937
Blood parathyroid hormone decreased 135.62 13.98 90 59458 12126 90556773
Red blood cell sedimentation rate 133.67 13.98 64 59484 4594 90564305
Aphasia 129.33 13.98 150 59398 42662 90526237
Crystal urine present 128.25 13.98 45 59503 1445 90567454
Cataract 125.66 13.98 193 59355 71899 90497000
Swelling 124.32 13.98 60 59488 418998 90149901
Panniculitis 124.18 13.98 91 59457 14367 90554532
Pericarditis 123.22 13.98 16 59532 270135 90298764
Impaired healing 122.41 13.98 8 59540 234191 90334708
Dysarthria 120.02 13.98 163 59385 54319 90514580
Folliculitis 120.01 13.98 3 59545 204350 90364549
Helicobacter infection 117.82 13.98 8 59540 226842 90342057
Granuloma skin 112.12 13.98 76 59472 10604 90558295
Skin necrosis 111.39 13.98 91 59457 16850 90552049
Culture urine positive 111.12 13.98 53 59495 3772 90565127
Death 109.45 13.98 84 59464 456467 90112432
Type 2 diabetes mellitus 109.06 13.98 6 59542 203238 90365661
Haemoglobin urine present 109.06 13.98 34 59514 748 90568151
Skin exfoliation 107.55 13.98 174 59374 67739 90501160
Ulcer 105.72 13.98 119 59429 32763 90536136
Rheumatoid nodule 105.44 13.98 95 59453 20071 90548828
Red cell distribution width increased 102.96 13.98 76 59472 12131 90556768
Influenza like illness 100.75 13.98 186 59362 80425 90488474
Bacterial test positive 100.74 13.98 56 59492 5483 90563416
Tendonitis 100.72 13.98 95 59453 21277 90547622
Liver injury 98.31 13.98 3 59545 170564 90398335
Irritable bowel syndrome 95.28 13.98 12 59536 207436 90361463
Specific gravity urine decreased 91.68 13.98 30 59518 775 90568124
Blood cholesterol increased 90.90 13.98 14 59534 207998 90360901
Lymphocyte percentage decreased 89.84 13.98 43 59505 3084 90565815
Alanine aminotransferase abnormal 88.28 13.98 51 59497 5375 90563524
Body temperature increased 85.47 13.98 125 59423 44585 90524314
Bacterial test 85.35 13.98 31 59517 1102 90567797
Alopecia 83.99 13.98 122 59426 494949 90073950
Oesophageal spasm 83.93 13.98 42 59506 3319 90565580
Paradoxical drug reaction 82.81 13.98 50 59498 5716 90563183
Neutrophil percentage increased 82.36 13.98 40 59508 2963 90565936
Drug ineffective 81.97 13.98 554 58994 1383744 89185155
Heart rate increased 81.82 13.98 209 59339 112693 90456206
Fear of injection 80.93 13.98 57 59491 8458 90560441
Dysphagia 80.49 13.98 207 59341 112071 90456828
Headache 77.41 13.98 886 58662 861860 89707039
Hepatic enzyme increased 75.95 13.98 75 59473 360661 90208238
Arthritis 75.66 13.98 262 59286 167053 90401846
Stress 75.61 13.98 166 59382 81229 90487670
Eosinophil percentage increased 73.62 13.98 27 59521 987 90567912
Arthropathy 72.76 13.98 80 59468 366162 90202737
Heart sounds 70.45 13.98 27 59521 1117 90567782
Oropharyngeal pain 70.16 13.98 200 59348 114987 90453912
Vascular malformation 69.69 13.98 24 59524 728 90568171
Eosinophil count increased 69.13 13.98 62 59486 13019 90555880
Blister 68.97 13.98 41 59507 254957 90313942
Oesophageal pain 68.21 13.98 40 59508 4334 90564565
Prolonged expiration 67.98 13.98 27 59521 1230 90567669
Paranasal cyst 67.95 13.98 24 59524 786 90568113
Body temperature decreased 67.86 13.98 81 59467 23735 90545164
Alveolitis 67.44 13.98 35 59513 2986 90565913
Hypercalcaemia 67.29 13.98 97 59451 34143 90534756
Anxiety 66.79 13.98 389 59159 309383 90259516
Basal cell carcinoma 66.22 13.98 95 59453 33294 90535605
Infusion site pain 66.14 13.98 73 59475 19665 90549234
Blood pressure fluctuation 65.55 13.98 121 59427 52292 90516607
Monocyte percentage increased 65.52 13.98 26 59522 1182 90567717
Osteoarthritis 64.41 13.98 24 59524 195706 90373193
Poor venous access 63.33 13.98 71 59477 19456 90549443
Urinary retention 62.89 13.98 99 59449 37645 90531254
Blood creatinine decreased 62.82 13.98 44 59504 6471 90562428
Mean cell haemoglobin concentration increased 62.37 13.98 21 59527 594 90568305
Protein urine present 60.07 13.98 44 59504 6940 90561959
Bursitis 59.51 13.98 8 59540 131646 90437253
Gastric disorder 59.03 13.98 90 59458 33294 90535605
CFTR gene mutation 57.49 13.98 16 59532 233 90568666
Mastoiditis 57.40 13.98 26 59522 1644 90567255
Feeling hot 57.12 13.98 145 59403 77863 90491036
Obesity 56.94 13.98 3 59545 105504 90463395
Ill-defined disorder 55.48 13.98 26 59522 184865 90384034
Heart rate decreased 55.32 13.98 114 59434 53391 90515508
Drug interaction 55.31 13.98 60 59488 276393 90292506
Monocyte count decreased 54.93 13.98 29 59519 2562 90566337
Haematocrit decreased 54.11 13.98 98 59450 41734 90527165
Toxicity to various agents 53.78 13.98 66 59482 287780 90281119
Drug eruption 53.71 13.98 89 59459 35318 90533581
Chills 53.12 13.98 199 59349 131782 90437117
Blood uric acid decreased 52.06 13.98 20 59528 833 90568066
Blood thyroid stimulating hormone increased 51.58 13.98 45 59503 9110 90559789
Gait inability 51.58 13.98 16 59532 146440 90422459
Infection 51.40 13.98 100 59448 361994 90206905
Joint range of motion decreased 51.15 13.98 13 59535 135630 90433269
Myocardial reperfusion injury 51.09 13.98 13 59535 131 90568768
Muscular weakness 50.83 13.98 269 59279 206397 90362502
Hyponatraemia 49.97 13.98 13 59535 133525 90435374
Maternal exposure during pregnancy 49.77 13.98 101 59447 359962 90208937
Injury 48.91 13.98 35 59513 197314 90371585
Lip dry 48.44 13.98 5 59543 100950 90467949
Throat irritation 48.29 13.98 102 59446 48593 90520306
Red cell distribution width decreased 47.75 13.98 25 59523 2171 90566728
Nitrite urine present 47.51 13.98 20 59528 1059 90567840
Completed suicide 47.36 13.98 18 59530 145040 90423859
Sleep disorder 46.66 13.98 37 59511 197993 90370906
Lung disorder 46.65 13.98 20 59528 149863 90419036
Granuloma 46.60 13.98 36 59512 6149 90562750
Intestinal pseudo-obstruction 46.06 13.98 20 59528 1143 90567756
pH urine increased 45.89 13.98 15 59533 386 90568513
Multiple sclerosis relapse 45.57 13.98 104 59444 52201 90516698
Thrombocytopenia 45.52 13.98 42 59506 208683 90360216
Gastrointestinal stoma output abnormal 45.21 13.98 15 59533 405 90568494
Alanine aminotransferase increased 43.99 13.98 174 59374 118164 90450735
Urine leukocyte esterase 43.96 13.98 12 59536 162 90568737
Rash pruritic 43.65 13.98 136 59412 82078 90486821
Liver disorder 43.15 13.98 13 59535 121256 90447643
Cerebrovascular accident 43.02 13.98 178 59370 123355 90445544
Arteriovenous fistula occlusion 42.95 13.98 14 59534 357 90568542
Loss of personal independence in daily activities 42.70 13.98 190 59358 135915 90432984
Neutrophil count increased 42.67 13.98 58 59490 19332 90549567
Nasopharyngitis 41.84 13.98 430 59118 406674 90162225
Prescribed overdose 41.67 13.98 7 59541 97618 90471281
Anuria 41.56 13.98 50 59498 14768 90554131
Feeling abnormal 41.33 13.98 218 59330 167017 90401882
Creatinine urine decreased 41.24 13.98 13 59535 297 90568602
Bradycardia 41.14 13.98 135 59413 83712 90485187
Extrapyramidal disorder 40.88 13.98 52 59496 16251 90552648
Acute kidney injury 40.84 13.98 94 59454 320293 90248606
Skin ulcer 40.81 13.98 97 59451 49978 90518921
Peripheral venous disease 40.67 13.98 4 59544 83917 90484982
Epilepsy 39.62 13.98 4 59544 82202 90486697
Discomfort 39.58 13.98 75 59473 274260 90294639
Blue toe syndrome 39.25 13.98 14 59534 472 90568427
Joint injury 39.08 13.98 74 59474 32590 90536309
Obstructive defaecation 38.75 13.98 12 59536 258 90568641
Hip arthroplasty 38.65 13.98 3 59545 76205 90492694
Red blood cell count increased 38.42 13.98 26 59522 3617 90565282
Blood thyroid stimulating hormone decreased 38.08 13.98 31 59517 5709 90563190
Stoma site dermatitis 38.07 13.98 12 59536 274 90568625
Red blood cells urine 37.76 13.98 14 59534 528 90568371
Myelocyte count increased 37.48 13.98 13 59535 403 90568496
Anaemia 37.02 13.98 114 59434 352688 90216211
Lip pruritus 36.95 13.98 18 59530 1342 90567557
Leukocyturia 36.80 13.98 19 59529 1603 90567296
Malaise 36.60 13.98 564 58984 585422 89983477
Blood pressure systolic increased 36.19 13.98 102 59446 58243 90510656
Contraindicated product administered 36.09 13.98 100 59448 320039 90248860
Inappropriate schedule of product administration 36.06 13.98 194 59354 149739 90419160
Insomnia 36.05 13.98 356 59192 333118 90235781
Depressive symptom 36.03 13.98 29 59519 5256 90563643
Vertigo 35.69 13.98 114 59434 69697 90499202
Heart rate irregular 35.47 13.98 60 59488 24208 90544691
Erythema 35.44 13.98 265 59283 228981 90339918
Thyroxine free increased 35.33 13.98 16 59532 1011 90567888
Specific gravity urine increased 35.24 13.98 11 59537 243 90568656
Pharyngeal inflammation 34.85 13.98 16 59532 1044 90567855
Night sweats 34.38 13.98 21 59527 128745 90440154
Oedema peripheral 34.23 13.98 74 59474 257841 90311058
Mean cell haemoglobin decreased 34.13 13.98 29 59519 5666 90563233
Pancreatitis relapsing 33.79 13.98 17 59531 1359 90567540
Red blood cell count decreased 33.76 13.98 86 59462 46265 90522634
Congenital megaureter 33.57 13.98 9 59539 113 90568786
Cardiac failure 33.46 13.98 15 59533 109481 90459418
Rheumatoid lung 33.38 13.98 25 59523 4078 90564821
Cardiac failure congestive 32.63 13.98 12 59536 98682 90470217
Lower respiratory tract infection 32.37 13.98 73 59475 250586 90318313
Mean cell haemoglobin increased 32.23 13.98 24 59524 3881 90565018
Band neutrophil percentage increased 32.20 13.98 10 59538 217 90568682
Transfusion 32.13 13.98 48 59500 17440 90551459
Gingival bleeding 31.92 13.98 44 59504 14859 90554040
Wound infection 31.85 13.98 15 59533 106387 90462512
Vitamin B12 decreased 31.74 13.98 27 59521 5283 90563616
Brain death 31.60 13.98 24 59524 3997 90564902
Urine oxalate increased 31.57 13.98 10 59538 232 90568667
Lymphoedema 31.57 13.98 42 59506 13711 90555188
Otitis media 31.37 13.98 28 59520 5842 90563057
Respiration abnormal 31.19 13.98 32 59516 7931 90560968
Appetite disorder 30.98 13.98 34 59514 9099 90559800
Road traffic accident 30.96 13.98 16 59532 107610 90461289
Productive cough 30.83 13.98 116 59432 76947 90491952
Band sensation 30.30 13.98 15 59533 1158 90567741
Tri-iodothyronine free decreased 30.26 13.98 11 59537 392 90568507
Foetal heart rate abnormal 30.00 13.98 14 59534 948 90567951
Hyperkalaemia 29.23 13.98 4 59544 64960 90503939
Live birth 29.02 13.98 8 59540 79099 90489800
Drug hypersensitivity 29.01 13.98 182 59366 463427 90105472
Multiple organ dysfunction syndrome 28.94 13.98 5 59543 68331 90500568
Therapeutic product effect decreased 28.89 13.98 90 59458 277481 90291418
Endoscopic retrograde cholangiopancreatography 28.29 13.98 9 59539 212 90568687
Injection site pain 28.23 13.98 44 59504 173655 90395244
Bulimia nervosa 27.66 13.98 11 59537 503 90568396
Depressed mood 27.51 13.98 84 59464 50138 90518761
Noninfective encephalitis 27.29 13.98 11 59537 521 90568378
Stomatitis 27.24 13.98 91 59457 274607 90294292
Osteomyelitis 27.23 13.98 58 59490 27788 90541111
Mean cell volume decreased 27.12 13.98 23 59525 4483 90564416
Disease progression 27.08 13.98 38 59510 156577 90412322
Rales 27.04 13.98 42 59506 15785 90553114
Allergic sinusitis 26.98 13.98 17 59531 2096 90566803
Angioedema 26.92 13.98 5 59543 64871 90504028
Vision blurred 26.71 13.98 143 59405 110150 90458749
Crystalluria 26.71 13.98 11 59537 551 90568348
Renal failure 26.66 13.98 28 59520 130979 90437920
Skin papilloma 26.47 13.98 25 59523 5605 90563294
Stoma site inflammation 26.44 13.98 12 59536 762 90568137
Band neutrophil count increased 26.44 13.98 10 59538 399 90568500
Musculoskeletal pain 26.32 13.98 45 59503 171206 90397693
Fatigue 26.04 13.98 964 58584 1153059 89415840
Urinary casts 26.04 13.98 12 59536 790 90568109
Hepatic cirrhosis 25.98 13.98 5 59543 63248 90505651
Hiccups 25.88 13.98 19 59529 3007 90565892
Product quality issue 25.63 13.98 10 59538 79315 90489584
Wheezing 25.62 13.98 76 59472 238004 90330895
Drug ineffective for unapproved indication 25.57 13.98 99 59449 66545 90502354
Mean cell haemoglobin concentration decreased 25.42 13.98 22 59526 4406 90564493
Tinnitus 25.41 13.98 74 59474 43028 90525871
Aspartate aminotransferase increased 25.29 13.98 134 59414 102803 90466096
Myelocyte percentage increased 25.20 13.98 8 59540 187 90568712
Fibromyalgia 25.09 13.98 62 59486 206207 90362692
Sciatica 25.08 13.98 18 59530 101364 90467535
Nasal congestion 25.07 13.98 115 59433 83299 90485600
Neuropathy peripheral 24.94 13.98 32 59516 136938 90431961
Extensor plantar response 24.79 13.98 14 59534 1413 90567486
Infusion site extravasation 24.42 13.98 32 59516 10296 90558603
Vomiting 24.39 13.98 684 58864 787609 89781290
Monocyte count increased 24.38 13.98 30 59518 9067 90559832
Tachycardia 24.20 13.98 182 59366 157491 90411408
Concussion 24.14 13.98 33 59515 11058 90557841
Joint swelling 24.11 13.98 213 59335 503087 90065812
Treatment noncompliance 23.71 13.98 3 59545 51724 90517175
Septic shock 23.49 13.98 13 59535 84147 90484752
Injection site reaction 23.24 13.98 16 59532 92064 90476835
Renal pain 23.11 13.98 27 59521 7732 90561167
Mean cell volume increased 23.05 13.98 22 59526 4999 90563900
Teratoma benign 23.02 13.98 6 59542 67 90568832
Injection site extravasation 22.98 13.98 29 59519 8990 90559909
Oedema 22.98 13.98 62 59486 200233 90368666
Hypertonia 22.55 13.98 22 59526 5133 90563766
Dizziness 22.51 13.98 526 59022 588758 89980141
Underweight 22.44 13.98 13 59535 1377 90567522
Drug-induced liver injury 22.39 13.98 16 59532 90302 90478597
Clonus 22.33 13.98 23 59525 5727 90563172
Exostosis 22.25 13.98 4 59544 53130 90515769
Feeling cold 22.16 13.98 53 59495 27412 90541487
Urobilinogen urine increased 21.98 13.98 8 59540 286 90568613
Memory impairment 21.93 13.98 62 59486 197182 90371717
Picornavirus infection 21.91 13.98 6 59542 82 90568817
Multiple sclerosis 21.68 13.98 53 59495 27787 90541112
Retinal depigmentation 21.59 13.98 8 59540 301 90568598
Hypersensitivity 21.52 13.98 193 59355 454484 90114415
Synovitis 21.36 13.98 128 59420 329624 90239275
Respiratory disorder 21.22 13.98 8 59540 64808 90504091
Foetal exposure during pregnancy 20.90 13.98 69 59479 42906 90525993
Musculoskeletal disorder 20.89 13.98 45 59503 21724 90547175
Tremor 20.86 13.98 172 59376 153001 90415898
Dysmenorrhoea 20.56 13.98 20 59528 4652 90564247
Chronic kidney disease 20.55 13.98 4 59544 50187 90518712
Adverse drug reaction 20.49 13.98 28 59520 116673 90452226
Onychomadesis 20.30 13.98 3 59545 45995 90522904
Gastrointestinal stoma complication 20.26 13.98 15 59533 2404 90566495
Foot deformity 20.14 13.98 7 59541 59644 90509255
Metabolic acidosis 19.74 13.98 6 59542 55670 90513229
Thyroid disorder 19.69 13.98 39 59509 17746 90551153
Pulmonary fibrosis 19.69 13.98 25 59523 107478 90461421
Stoma site pain 19.61 13.98 12 59536 1405 90567494
Immune thrombocytopenia 19.54 13.98 33 59515 13293 90555606
Disability assessment scale score increased 19.53 13.98 18 59530 3913 90564986
Mental status changes 19.52 13.98 3 59545 44676 90524223
Drug intolerance 19.47 13.98 194 59354 447397 90121502
Infusion site scar 19.46 13.98 9 59539 597 90568302
Infusion site discomfort 19.24 13.98 13 59535 1803 90567096
Poor quality sleep 19.22 13.98 47 59501 24646 90544253
Knee arthroplasty 19.01 13.98 16 59532 83166 90485733
Creatinine urine increased 19.01 13.98 7 59541 259 90568640
Blood pressure diastolic abnormal 18.97 13.98 41 59507 19840 90549059
Device loosening 18.95 13.98 10 59538 883 90568016
Fumbling 18.79 13.98 6 59542 143 90568756
Pyrexia 18.73 13.98 567 58981 659918 89908981
Lactic acidosis 18.71 13.98 5 59543 50458 90518441
Breast cancer 18.69 13.98 6 59542 53755 90515144
Thyroid cyst 18.65 13.98 9 59539 657 90568242
Lower limb fracture 18.65 13.98 17 59531 84996 90483903
Drug abuse 18.63 13.98 16 59532 82331 90486568
Psoriasis 18.58 13.98 163 59385 147591 90421308
Liver function test increased 18.58 13.98 17 59531 84838 90484061
Product dose omission issue 18.48 13.98 114 59434 291573 90277326
Hospitalisation 18.48 13.98 35 59513 128065 90440834
Faeces hard 18.39 13.98 16 59532 3226 90565673
Interstitial lung disease 18.34 13.98 14 59534 76391 90492508
Limbal swelling 18.33 13.98 4 59544 19 90568880
Deep vein thrombosis 18.17 13.98 20 59528 91600 90477299
Thyroid stimulating immunoglobulin 18.02 13.98 5 59543 72 90568827
Hypokalaemia 17.90 13.98 37 59511 131079 90437820
Abdominal pain 17.89 13.98 362 59186 395359 90173540
Coma 17.83 13.98 13 59535 72619 90496280
Lupus-like syndrome 17.80 13.98 5 59543 48841 90520058
Muscle contractions involuntary 17.73 13.98 15 59533 2913 90565986
Lipaemic index score 17.71 13.98 5 59543 77 90568822
Menstrual disorder 17.69 13.98 21 59527 6117 90562782
Endometrial ablation 17.62 13.98 10 59538 1019 90567880
Flank pain 17.61 13.98 39 59509 19183 90549716
Ear pruritus 17.53 13.98 22 59526 6781 90562118
Rheumatoid arthritis 17.50 13.98 335 59213 362279 90206620
Coeliac disease 17.35 13.98 4 59544 44606 90524293
Rhabdomyolysis 17.33 13.98 6 59542 51250 90517649
Immature granulocyte count increased 17.28 13.98 8 59540 532 90568367
Therapeutic response shortened 17.23 13.98 43 59505 22836 90546063
Migraine 17.15 13.98 196 59352 190196 90378703
Gestational hypertension 17.15 13.98 15 59533 3047 90565852
Blood luteinising hormone decreased 17.14 13.98 4 59544 27 90568872
Apallic syndrome 17.13 13.98 9 59539 787 90568112
Osteoporosis 17.11 13.98 23 59525 96508 90472391
Vertebral lateral recess stenosis 17.10 13.98 7 59541 345 90568554
Hypoxic-ischaemic encephalopathy 16.92 13.98 18 59530 4650 90564249
Osteoarthropathy 16.80 13.98 7 59541 361 90568538
Ligamentum flavum hypertrophy 16.64 13.98 7 59541 370 90568529
Basophil count increased 16.58 13.98 10 59538 1141 90567758
Haemoglobin decreased 16.56 13.98 171 59377 161785 90407114
Respiratory failure 16.52 13.98 33 59515 118385 90450514
Periorbital swelling 16.51 13.98 18 59530 4780 90564119
Klebsiella test positive 16.50 13.98 11 59537 1492 90567407
Hyperhidrosis 16.44 13.98 149 59399 136156 90432743
Human chorionic gonadotropin decreased 16.30 13.98 5 59543 104 90568795
Dry throat 16.30 13.98 23 59525 7937 90560962
Dengue fever 16.08 13.98 9 59539 893 90568006
Large intestinal ulcer haemorrhage 15.83 13.98 5 59543 115 90568784
Limb discomfort 15.81 13.98 58 59490 38002 90530897
Imperforate hymen 15.69 13.98 3 59545 6 90568893
Hepatitis 15.69 13.98 14 59534 70725 90498174
Cyanosis neonatal 15.55 13.98 7 59541 436 90568463
Joint stiffness 15.52 13.98 17 59531 78025 90490874
Urine bilirubin increased 15.40 13.98 4 59544 44 90568855
Myelosuppression 15.36 13.98 8 59540 53583 90515316
Monocyte count abnormal 15.30 13.98 6 59542 264 90568635
Decerebrate posture 15.29 13.98 5 59543 129 90568770
Hypoglycaemia 15.28 13.98 14 59534 69834 90499065
Pollakiuria 15.17 13.98 52 59496 32953 90535946
Red blood cell elliptocytes present 15.16 13.98 4 59544 47 90568852
Taste disorder 15.13 13.98 11 59537 61535 90507364
Haematocrit increased 15.11 13.98 14 59534 3064 90565835
Weight decreased 15.06 13.98 341 59207 379569 90189330
Chronic gastrointestinal bleeding 14.86 13.98 5 59543 141 90568758
Respiratory disorder neonatal 14.78 13.98 10 59538 1391 90567508
Loefgren syndrome 14.73 13.98 5 59543 145 90568754
Abdominal discomfort 14.65 13.98 223 59325 477105 90091794
Femur fracture 14.57 13.98 6 59542 46076 90522823
Drug monitoring procedure not performed 14.43 13.98 8 59540 779 90568120
Suicide attempt 14.37 13.98 17 59531 75382 90493517
Hypopnoea 14.18 13.98 16 59532 4415 90564484
Poor feeding infant 14.13 13.98 7 59541 541 90568358
Pregnancy 14.10 13.98 12 59536 62035 90506864
Enterobacter bacteraemia 14.07 13.98 8 59540 818 90568081
Blood pressure systolic abnormal 14.04 13.98 36 59512 19442 90549457

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 350.46 15.92 388 15637 185315 42419995
Aplastic anaemia 328.12 15.92 136 15889 12248 42593062
Epidural lipomatosis 161.58 15.92 49 15976 1751 42603559
Respiratory depression 156.23 15.92 94 15931 18774 42586536
Tenosynovitis 153.43 15.92 60 15965 4635 42600675
Enthesopathy 151.81 15.92 60 15965 4768 42600542
Victim of child abuse 135.77 15.92 39 15986 1150 42604160
Drug dependence 125.86 15.92 97 15928 28997 42576313
Juvenile idiopathic arthritis 123.90 15.92 44 15981 2595 42602715
Tongue disorder 122.16 15.92 53 15972 5330 42599980
Mucosal inflammation 115.42 15.92 116 15909 49258 42556052
C-reactive protein abnormal 114.39 15.92 60 15965 9201 42596109
Child abuse 100.70 15.92 29 15996 863 42604447
Product prescribing error 97.80 15.92 80 15945 26032 42579278
Tendonitis 94.26 15.92 54 15971 9840 42595470
Alanine aminotransferase abnormal 90.85 15.92 42 15983 4902 42600408
Synovitis 85.59 15.92 60 15965 15507 42589803
Foetal exposure during pregnancy 82.13 15.92 95 15930 47216 42558094
Blood pressure fluctuation 81.51 15.92 73 15952 26835 42578475
Erythema 81.02 15.92 146 15879 108647 42496663
Red blood cell sedimentation rate 74.33 15.92 24 16001 1056 42604254
Granuloma skin 72.34 15.92 24 16001 1151 42604159
Death 69.67 15.92 46 15979 471139 42134171
Platelet transfusion 67.41 15.92 25 16000 1669 42603641
Nausea 65.99 15.92 309 15716 396490 42208820
Blood parathyroid hormone decreased 64.47 15.92 24 16001 1619 42603691
Loss of personal independence in daily activities 59.42 15.92 83 15942 49733 42555577
Panniculitis 57.87 15.92 24 16001 2157 42603153
Heart rate irregular 55.56 15.92 47 15978 16003 42589307
Inappropriate schedule of product administration 54.63 15.92 115 15910 95787 42509523
Product use issue 54.55 15.92 101 15924 76650 42528660
Obesity 52.51 15.92 46 15979 16413 42588897
Psoriatic arthropathy 51.69 15.92 55 15970 24912 42580398
Rheumatoid nodule 50.57 15.92 24 16001 2971 42602339
Tenderness 43.68 15.92 32 15993 8851 42596459
Renal fusion anomaly 40.99 15.92 9 16016 84 42605226
Lymphocyte percentage decreased 40.91 15.92 19 16006 2240 42603070
Heart rate decreased 40.80 15.92 59 15966 36473 42568837
Enterococcus test positive 39.57 15.92 17 16008 1668 42603642
Urine abnormality 37.98 15.92 18 16007 2221 42603089
Alanine aminotransferase increased 37.07 15.92 94 15931 88312 42516998
Infusion related reaction 37.05 15.92 75 15950 60731 42544579
Dermal cyst 36.75 15.92 17 16008 1986 42603324
Aspartate aminotransferase increased 35.48 15.92 85 15940 77078 42528232
Perineal infection 34.94 15.92 12 16013 640 42604670
Transfusion 34.78 15.92 30 15995 10484 42594826
Umbilical hernia 34.69 15.92 23 16002 5424 42599886
Optic nerve operation 34.13 15.92 11 16014 481 42604829
Tooth injury 33.98 15.92 14 16011 1237 42604073
Skin necrosis 33.91 15.92 24 16001 6290 42599020
Congenital eye disorder 33.05 15.92 9 16016 217 42605093
Anomalous pulmonary venous connection 32.36 15.92 8 16017 130 42605180
Scrotal infection 31.93 15.92 12 16013 831 42604479
Neutrophil percentage increased 30.91 15.92 15 16010 1950 42603360
Drug interaction 30.82 15.92 33 15992 266966 42338344
Infected dermal cyst 30.75 15.92 12 16013 921 42604389
C-reactive protein increased 30.28 15.92 71 15954 63489 42541821
Vomiting 30.10 15.92 199 15826 289524 42315786
Hypercalcaemia 29.21 15.92 35 15990 18023 42587287
Anaemia 28.76 15.92 38 15987 280240 42325070
Congenital skin dimples 28.55 15.92 8 16017 215 42605095
Infection 27.81 15.92 99 15926 111969 42493341
Atrial septal defect 27.01 15.92 23 16002 7896 42597414
Ventricular septal defect 26.63 15.92 18 16007 4381 42600929
Epispadias 25.98 15.92 7 16018 162 42605148
pH urine increased 25.96 15.92 6 16019 72 42605238
Renal impairment 25.91 15.92 5 16020 110223 42495087
Contraindicated product administered 25.60 15.92 39 15986 25233 42580077
Arteriovenous fistula 25.02 15.92 11 16014 1141 42604169
Chest discomfort 23.95 15.92 65 15960 63551 42541759
Hyperaesthesia 23.89 15.92 19 16006 5933 42599377
Tendon pain 23.63 15.92 15 16010 3285 42602025
Cholinergic syndrome 23.42 15.92 9 16016 662 42604648
Intracranial aneurysm 23.39 15.92 12 16013 1756 42603554
Social (pragmatic) communication disorder 23.00 15.92 6 16019 122 42605188
Anal haemorrhage 22.95 15.92 14 16011 2859 42602451
Aplasia 22.80 15.92 17 16008 4826 42600484
Treatment failure 22.60 15.92 63 15962 62561 42542749
Blood pressure systolic increased 21.36 15.92 38 15987 27930 42577380
Specific gravity urine increased 20.94 15.92 6 16019 175 42605135
Rheumatoid arthritis 20.85 15.92 48 15977 42392 42562918
Hyperkalaemia 20.34 15.92 3 16022 80455 42524855
Lymphocyte count decreased 20.24 15.92 37 15988 27772 42577538
Urine ketone body present 20.01 15.92 10 16015 1384 42603926
Escherichia infection 19.95 15.92 23 16002 11373 42593937
Toxicity to various agents 19.71 15.92 35 15990 229101 42376209
White blood cells urine positive 19.70 15.92 10 16015 1431 42603879
Hepatic enzyme increased 19.50 15.92 49 15976 45735 42559575
Completed suicide 19.50 15.92 6 16019 96459 42508851
Urine leukocyte esterase positive 19.17 15.92 7 16018 447 42604863
Band neutrophil percentage increased 19.15 15.92 5 16020 102 42605208
Restrictive cardiomyopathy 19.05 15.92 8 16017 742 42604568
Off label use 18.74 15.92 340 15685 637995 41967315
Mobility decreased 18.54 15.92 41 15984 35265 42570045
Red blood cell elliptocytes present 18.42 15.92 5 16020 119 42605191
Headache 18.31 15.92 153 15872 239216 42366094
Intentional product use issue 18.27 15.92 64 15961 71769 42533541
Cardiac failure 17.74 15.92 9 16016 106847 42498463
Drug hypersensitivity 17.56 15.92 79 15946 99310 42506000
Rheumatoid lung 17.44 15.92 8 16017 916 42604394
Pyloric stenosis 17.41 15.92 8 16017 920 42604390
Microcephaly 17.36 15.92 8 16017 926 42604384
Hypogonadism 17.27 15.92 11 16014 2423 42602887
Anal fistula 17.13 15.92 16 16009 6197 42599113
Hydrothorax 17.06 15.92 7 16018 612 42604698
Congenital umbilical hernia 16.95 15.92 6 16019 350 42604960
Neutrophil percentage decreased 16.85 15.92 6 16019 356 42604954
Peripheral nerve lesion 16.72 15.92 5 16020 170 42605140
Blood pressure diastolic decreased 16.60 15.92 20 16005 10355 42594955
Prostate examination abnormal 16.57 15.92 6 16019 374 42604936
Fasciotomy 16.36 15.92 4 16021 62 42605248
Disease progression 16.27 15.92 18 16007 143638 42461672
Basal cell carcinoma 16.23 15.92 30 15995 22703 42582607
Ulcer 16.13 15.92 25 16000 16416 42588894
Blood glucose increased 15.99 15.92 4 16021 73695 42531615

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 489.12 13.80 800 71691 315967 110200841
Urine abnormality 484.31 13.80 193 72298 8903 110507905
Aplastic anaemia 424.49 13.80 239 72252 24069 110492739
Chest discomfort 328.00 13.80 482 72009 173366 110343442
Arterial occlusive disease 321.27 13.80 170 72321 15138 110501670
Neurologic neglect syndrome 317.61 13.80 144 72347 9154 110507654
Gangrene 313.62 13.80 171 72320 16170 110500638
Carotid artery thrombosis 309.53 13.80 143 72348 9495 110507313
Enthesopathy 306.37 13.80 154 72337 12324 110504484
Urine leukocyte esterase positive 302.06 13.80 108 72383 3678 110513130
Lymphocyte count decreased 294.82 13.80 267 72224 56976 110459832
Adjustment disorder 291.08 13.80 142 72349 10653 110506155
Tenosynovitis 284.01 13.80 160 72331 16123 110500685
Personality disorder 273.48 13.80 144 72347 12693 110504115
Tongue disorder 272.67 13.80 149 72342 14149 110502659
Sensory loss 240.82 13.80 159 72332 21298 110495510
Affect lability 231.03 13.80 147 72344 18490 110498318
Sneezing 230.31 13.80 181 72310 31803 110485005
White blood cells urine positive 218.06 13.80 104 72387 7420 110509388
Respiratory tract congestion 216.55 13.80 172 72319 30685 110486123
Skin haemorrhage 215.28 13.80 157 72334 24670 110492138
Nausea 214.33 13.80 1462 71029 1234228 109282580
Sinus congestion 209.95 13.80 168 72323 30291 110486517
Sinus disorder 207.65 13.80 172 72319 32556 110484252
Hemiplegia 199.65 13.80 145 72346 22637 110494171
Cystitis 199.36 13.80 231 72260 65805 110451003
Death 199.29 13.80 105 72386 698764 109818044
Blood urine present 198.26 13.80 148 72343 24097 110492711
Red blood cell sedimentation rate 198.08 13.80 87 72404 5127 110511681
Motor dysfunction 195.16 13.80 147 72344 24259 110492549
Rhinorrhoea 192.54 13.80 284 72207 102382 110414426
Red blood cells urine positive 192.08 13.80 85 72406 5100 110511708
Muscle spasticity 191.76 13.80 171 72320 35744 110481064
Blood parathyroid hormone decreased 186.97 13.80 113 72378 12976 110503832
Coordination abnormal 186.47 13.80 145 72346 25083 110491725
Tendonitis 184.34 13.80 146 72345 25937 110490871
Eating disorder 180.99 13.80 155 72336 30703 110486105
Urinary sediment present 178.87 13.80 66 72425 2462 110514346
Panniculitis 171.31 13.80 114 72377 15468 110501340
Granuloma skin 165.28 13.80 99 72392 11184 110505624
Angina pectoris 163.56 13.80 203 72288 62092 110454716
Alanine aminotransferase abnormal 163.53 13.80 92 72399 9242 110507566
Urine ketone body present 161.90 13.80 69 72422 3777 110513031
Flushing 157.80 13.80 262 72229 104474 110412334
Blood pressure increased 154.77 13.80 445 72046 257928 110258880
Hemiparesis 152.05 13.80 165 72326 43738 110473070
Rheumatoid nodule 150.75 13.80 117 72374 20179 110496629
Palpitations 143.23 13.80 320 72171 158892 110357916
Urine analysis abnormal 143.03 13.80 76 72415 6821 110509987
Influenza 142.29 13.80 331 72160 168770 110348038
Cataract 140.62 13.80 214 72277 79271 110437537
Skin necrosis 138.42 13.80 114 72377 21398 110495410
Neovascularisation 136.49 13.80 49 72442 1688 110515120
Crystal urine present 134.03 13.80 50 72441 1924 110514884
Glossodynia 131.02 13.80 3 72488 222001 110294807
Epidural lipomatosis 128.19 13.80 49 72442 2018 110514790
Cough 126.59 13.80 618 71873 461023 110055785
Drug interaction 125.85 13.80 87 72404 500096 110016712
Blood pressure fluctuation 121.96 13.80 194 72297 74630 110442178
Headache 121.65 13.80 990 71501 881387 109635421
Lymphocyte percentage decreased 120.06 13.80 62 72429 5248 110511560
Influenza like illness 119.77 13.80 211 72280 88201 110428607
Systemic lupus erythematosus 115.75 13.80 15 72476 254323 110262485
Victim of child abuse 113.69 13.80 39 72452 1172 110515636
Aphasia 110.28 13.80 163 72328 58834 110457974
Toxicity to various agents 105.26 13.80 96 72395 480459 110036349
Red cell distribution width increased 104.41 13.80 89 72402 17513 110499295
Neutrophil percentage increased 104.32 13.80 55 72436 4858 110511950
Culture urine positive 99.88 13.80 53 72438 4743 110512065
Loss of personal independence in daily activities 99.23 13.80 268 72223 149752 110367056
Hand deformity 99.15 13.80 13 72478 218493 110298315
Specific gravity urine decreased 96.88 13.80 32 72459 854 110515954
Arthritis 95.82 13.80 284 72207 167302 110349506
Haemoglobin urine present 95.29 13.80 32 72459 900 110515908
Bacterial test 95.16 13.80 34 72457 1155 110515653
Wound 95.08 13.80 19 72472 234418 110282390
Fear of injection 95.08 13.80 64 72427 8847 110507961
Body temperature increased 94.91 13.80 146 72345 54567 110462241
Acute kidney injury 94.60 13.80 170 72321 635260 109881548
Anaemia 93.05 13.80 134 72357 546952 109969856
Folliculitis 92.72 13.80 4 72487 167649 110349159
Pericarditis 92.63 13.80 16 72475 219098 110297710
Helicobacter infection 92.46 13.80 7 72484 181870 110334938
Ulcer 92.17 13.80 127 72364 42989 110473819
Bacterial test positive 91.66 13.80 60 72431 7917 110508891
Completed suicide 89.64 13.80 24 72467 242357 110274451
Oesophageal spasm 89.26 13.80 45 72446 3621 110513187
Hypercalcaemia 88.77 13.80 130 72361 46527 110470281
Dysarthria 87.02 13.80 179 72312 83942 110432866
Swelling 87.00 13.80 62 72429 350979 110165829
Type 2 diabetes mellitus 86.85 13.80 8 72483 177224 110339584
Erythema 86.19 13.80 399 72092 291048 110225760
Liver injury 85.18 13.80 3 72488 150410 110366398
Child abuse 84.90 13.80 29 72462 860 110515948
Impaired healing 83.95 13.80 14 72477 196703 110320105
Skin exfoliation 83.11 13.80 180 72311 87471 110429337
Basal cell carcinoma 83.06 13.80 124 72367 45146 110471662
Eosinophil percentage increased 82.23 13.80 33 72458 1549 110515259
Heart rate decreased 81.98 13.80 173 72318 82583 110434225
Heart rate irregular 80.96 13.80 106 72385 34168 110482640
Inappropriate schedule of product administration 79.07 13.80 303 72188 203334 110313474
Blood cholesterol increased 77.00 13.80 14 72477 184771 110332037
Heart rate increased 74.96 13.80 236 72255 143598 110373210
Poor venous access 74.34 13.80 86 72405 24436 110492372
Respiratory depression 74.09 13.80 98 72393 31903 110484905
Oesophageal pain 72.56 13.80 44 72447 5081 110511727
Hyponatraemia 72.50 13.80 26 72465 217627 110299181
Gastric disorder 72.42 13.80 99 72392 33258 110483550
Infusion site pain 72.03 13.80 72 72419 17347 110499461
Vascular malformation 71.71 13.80 25 72466 789 110516019
Heart sounds 70.54 13.80 27 72464 1116 110515692
Monocyte percentage increased 70.31 13.80 33 72458 2270 110514538
Oropharyngeal pain 69.61 13.80 221 72270 135055 110381753
Multiple sclerosis relapse 69.45 13.80 121 72370 50119 110466689
Irritable bowel syndrome 69.38 13.80 12 72479 164203 110352605
Paranasal cyst 69.15 13.80 25 72466 879 110515929
Body temperature decreased 67.51 13.80 101 72390 36834 110479974
Eosinophil count increased 67.47 13.80 76 72415 20982 110495826
Rheumatoid arthritis 67.44 13.80 380 72111 299233 110217575
Juvenile idiopathic arthritis 66.15 13.80 44 72447 5963 110510845
Anxiety 64.52 13.80 417 72074 344661 110172147
Hyperkalaemia 64.26 13.80 7 72484 135789 110381019
Nasopharyngitis 63.31 13.80 459 72032 393902 110122906
Cardiac failure 63.20 13.80 22 72469 187604 110329204
Prolonged expiration 62.55 13.80 27 72464 1525 110515283
Protein urine present 61.92 13.80 55 72436 11429 110505379
Dysphagia 61.63 13.80 231 72260 153369 110363439
Bursitis 60.71 13.80 7 72484 129911 110386897
Feeling hot 59.46 13.80 162 72329 90944 110425864
Paradoxical drug reaction 58.96 13.80 50 72441 9767 110507041
Alanine aminotransferase increased 58.33 13.80 257 72234 183516 110333292
CFTR gene mutation 57.53 13.80 16 72475 233 110516575
Mean cell haemoglobin concentration increased 57.38 13.80 23 72468 1076 110515732
Osteoarthritis 57.20 13.80 24 72467 182599 110334209
Fatigue 57.05 13.80 1115 71376 1214843 109301965
pH urine increased 56.18 13.80 18 72473 435 110516373
Drug dependence 55.98 13.80 110 72381 49910 110466898
Transfusion 55.90 13.80 76 72415 25396 110491412
Drug ineffective 55.87 13.80 684 71807 1519856 108996952
Rash pruritic 55.84 13.80 166 72325 97903 110418905
Drug eruption 55.27 13.80 114 72377 53545 110463263
Alveolitis 54.97 13.80 35 72456 4404 110512404
Renal failure 54.83 13.80 41 72450 226533 110290275
Monocyte count decreased 54.36 13.80 33 72458 3818 110512990
Muscular weakness 53.84 13.80 312 72179 248156 110268652
Blood creatinine decreased 53.78 13.80 46 72445 9091 110507717
Stress 53.18 13.80 171 72320 105177 110411631
Red cell distribution width decreased 53.08 13.80 27 72464 2214 110514594
Multiple organ dysfunction syndrome 52.46 13.80 17 72474 151693 110365115
Myocardial reperfusion injury 51.04 13.80 13 72478 132 110516676
Throat irritation 49.64 13.80 109 72382 53443 110463365
Disease progression 49.61 13.80 52 72439 243982 110272826
Specific gravity urine increased 49.49 13.80 17 72474 513 110516295
Mastoiditis 49.19 13.80 27 72464 2584 110514224
Insomnia 49.12 13.80 404 72087 360186 110156622
Joint range of motion decreased 49.12 13.80 10 72481 121822 110394986
Rheumatoid lung 48.54 13.80 32 72459 4272 110512536
Nitrite urine present 48.18 13.80 21 72470 1214 110515594
Vomiting 47.79 13.80 850 71641 909825 109606983
Lip dry 47.76 13.80 5 72486 100078 110416730
Blood pressure systolic increased 47.74 13.80 141 72350 82850 110433958
Skin ulcer 47.49 13.80 119 72372 63526 110453282
Blood uric acid decreased 47.46 13.80 22 72469 1471 110515337
Respiratory failure 47.11 13.80 43 72448 215289 110301519
Cardiac failure congestive 47.04 13.80 20 72471 150980 110365828
Platelet transfusion 47.02 13.80 27 72464 2819 110513989
Thrombocytopenia 46.92 13.80 99 72392 348786 110168022
Granuloma 46.36 13.80 43 72448 9447 110507361
Band neutrophil percentage increased 45.82 13.80 15 72476 389 110516419
Interstitial lung disease 45.79 13.80 17 72474 139317 110377491
Feeling abnormal 45.22 13.80 236 72255 180475 110336333
Gastrointestinal stoma output abnormal 44.83 13.80 15 72476 417 110516391
Blister 44.50 13.80 50 72441 227326 110289482
Renal impairment 44.44 13.80 35 72456 188410 110328398
Mucosal inflammation 44.02 13.80 151 72340 95990 110420818
Oedema peripheral 43.58 13.80 94 72397 328566 110188242
Liver disorder 42.49 13.80 20 72471 142223 110374585
Malaise 42.20 13.80 646 71845 671173 109845635
Urine leukocyte esterase 41.87 13.80 12 72479 196 110516612
Blood thyroid stimulating hormone decreased 41.70 13.80 36 72455 7203 110509605
Blue toe syndrome 41.56 13.80 16 72475 672 110516136
Aspartate aminotransferase increased 41.50 13.80 211 72280 159725 110357083
Septic shock 41.44 13.80 26 72465 157502 110359306
Leukocyturia 41.19 13.80 23 72468 2277 110514531
Peripheral venous disease 40.66 13.80 4 72487 84113 110432695
Haematocrit decreased 40.60 13.80 115 72376 66002 110450806
Blood thyroid stimulating hormone increased 40.44 13.80 45 72446 12256 110504552
Red blood cell count increased 40.15 13.80 30 72461 4888 110511920
Obstructive defaecation 39.13 13.80 12 72479 250 110516558
Creatinine urine decreased 39.00 13.80 13 72478 357 110516451
Red blood cells urine 38.45 13.80 15 72476 653 110516155
Lymphoedema 38.13 13.80 48 72443 14881 110501927
Injury 38.06 13.80 36 72455 177229 110339579
Gait inability 38.01 13.80 21 72470 136355 110380453
Band sensation 37.78 13.80 17 72474 1061 110515747
Coma 37.70 13.80 15 72476 117854 110398954
Arteriovenous fistula occlusion 37.62 13.80 14 72477 535 110516273
Stoma site dermatitis 37.57 13.80 12 72479 287 110516521
Lip pruritus 37.47 13.80 18 72473 1304 110515504
Band neutrophil count increased 37.46 13.80 15 72476 700 110516108
Rhabdomyolysis 37.42 13.80 16 72475 120385 110396423
Ill-defined disorder 37.15 13.80 29 72462 156824 110359984
Otitis media 36.77 13.80 34 72457 7442 110509366
Enterococcus test positive 36.22 13.80 23 72468 2881 110513927
Respiration abnormal 35.95 13.80 38 72453 9771 110507037
Angioedema 35.94 13.80 10 72481 98490 110418318
Joint injury 35.49 13.80 80 72411 39914 110476894
Sleep disorder 35.37 13.80 47 72444 198597 110318211
Gastrointestinal haemorrhage 35.08 13.80 34 72457 165484 110351324
Epilepsy 35.05 13.80 11 72480 100198 110416610
Foetal heart rate abnormal 34.81 13.80 14 72477 661 110516147
Lung disorder 34.78 13.80 40 72451 180007 110336801
Mean cell haemoglobin concentration decreased 34.25 13.80 29 72462 5653 110511155
Deep vein thrombosis 34.24 13.80 25 72466 139862 110376946
Feeling cold 33.59 13.80 71 72420 33916 110482892
Product prescribing error 33.21 13.80 91 72400 51240 110465568
Musculoskeletal pain 32.89 13.80 43 72448 182980 110333828
Lactic acidosis 32.80 13.80 10 72481 92801 110424007
Urine oxalate increased 32.18 13.80 10 72481 218 110516590
Mean cell haemoglobin decreased 32.17 13.80 31 72460 7143 110509665
Pancreatitis relapsing 32.10 13.80 17 72474 1515 110515293
Vitamin B12 decreased 32.03 13.80 27 72464 5230 110511578
Endoscopic retrograde cholangiopancreatography 31.93 13.80 10 72481 224 110516584
Treatment noncompliance 31.57 13.80 5 72486 72985 110443823
Red blood cell count decreased 31.46 13.80 105 72386 65818 110450990
Urinary retention 30.64 13.80 108 72383 69575 110447233
Musculoskeletal disorder 30.56 13.80 54 72437 22610 110494198
Mean cell haemoglobin increased 30.48 13.80 27 72464 5590 110511218
Anuria 30.28 13.80 56 72435 24285 110492523
Myelosuppression 30.18 13.80 12 72479 94328 110422480
Chills 30.06 13.80 221 72270 190359 110326449
Thyroxine free increased 30.05 13.80 16 72475 1441 110515367
Red blood cell elliptocytes present 29.84 13.80 9 72482 177 110516631
Allergic sinusitis 29.70 13.80 17 72474 1764 110515044
Live birth 29.51 13.80 5 72486 69479 110447329
C-reactive protein abnormal 29.47 13.80 165 72326 129530 110387278
Vision blurred 29.23 13.80 164 72327 128858 110387950
Infusion site extravasation 29.07 13.80 37 72454 11597 110505211
Tri-iodothyronine free decreased 28.89 13.80 11 72480 448 110516360
Intestinal pseudo-obstruction 28.58 13.80 21 72470 3335 110513473
Perineal infection 28.26 13.80 13 72478 854 110515954
Prescribed overdose 28.25 13.80 11 72480 87570 110429238
Neutrophil count increased 28.20 13.80 67 72424 34585 110482223
Migraine 28.19 13.80 201 72290 171451 110345357
Mean cell volume decreased 28.17 13.80 26 72465 5676 110511132
Optic nerve operation 28.11 13.80 11 72480 483 110516325
Pharyngeal inflammation 27.62 13.80 16 72475 1698 110515110
Myelocyte count increased 27.60 13.80 13 72478 901 110515907
Wheezing 27.60 13.80 81 72410 255149 110261659
Hepatic function abnormal 27.53 13.80 12 72479 89283 110427525
Appetite disorder 27.52 13.80 33 72458 9736 110507072
Drug-induced liver injury 27.43 13.80 23 72468 120044 110396764
Chronic kidney disease 27.36 13.80 8 72483 76283 110440525
Agranulocytosis 27.23 13.80 4 72487 61756 110455052
Drug tolerance 27.01 13.80 43 72448 16542 110500266
Blood pressure diastolic abnormal 26.76 13.80 55 72436 25760 110491048
Night sweats 26.72 13.80 29 72462 133954 110382854
Psoriasis 26.62 13.80 170 72321 139823 110376985
Arthropathy 26.44 13.80 98 72393 287424 110229384
Alopecia 26.44 13.80 136 72355 364617 110152191
Scrotal infection 26.38 13.80 12 72479 768 110516040
Faeces hard 26.27 13.80 22 72469 4224 110512584
No adverse event 26.01 13.80 8 72483 73831 110442977
Sinusitis 25.91 13.80 303 72188 296385 110220423
Osteomyelitis 25.81 13.80 67 72424 36533 110480275
Orthostatic hypotension 25.56 13.80 6 72485 66243 110450565
Hepatic enzyme increased 25.37 13.80 116 72375 320776 110196032
Vertigo 24.95 13.80 118 72373 86752 110430056
Depressive symptom 24.65 13.80 29 72462 8385 110508423
Hot flush 24.57 13.80 97 72394 65939 110450869
Sleep apnoea syndrome 24.49 13.80 70 72421 40377 110476431
Pleural effusion 24.23 13.80 50 72441 177659 110339149
Metabolic acidosis 24.18 13.80 18 72473 99726 110417082
Skin papilloma 24.01 13.80 26 72465 6870 110509938
Dizziness 23.97 13.80 613 71878 697580 109819228
Mental status changes 23.84 13.80 10 72481 76112 110440696
Drug reaction with eosinophilia and systemic symptoms 23.82 13.80 12 72479 82083 110434725
Sedation 23.75 13.80 8 72483 69675 110447133
Myelocyte percentage increased 23.69 13.80 8 72483 229 110516579
Multiple sclerosis 23.47 13.80 52 72439 25646 110491162
Depressed mood 23.18 13.80 90 72401 60719 110456089
Memory impairment 23.16 13.80 60 72431 196884 110319924
Stoma site inflammation 23.15 13.80 12 72479 1023 110515785
Injection site reaction 23.01 13.80 15 72476 89055 110427753
Product quality issue 22.88 13.80 11 72480 77288 110439520
Dermal cyst 22.86 13.80 18 72473 3168 110513640
Haematuria 22.81 13.80 13 72478 82992 110433816
Crystalluria 22.78 13.80 13 72478 1342 110515466
Diabetes mellitus 22.75 13.80 19 72472 99362 110417446
Gingival bleeding 22.64 13.80 44 72447 19795 110497013
Oedema 22.44 13.80 67 72424 209909 110306899
Hyperglycaemia 22.44 13.80 14 72477 85076 110431732
Monocyte count increased 22.39 13.80 35 72456 13258 110503550
Blood pressure systolic abnormal 22.37 13.80 50 72441 24800 110492008
Acute respiratory distress syndrome 22.22 13.80 4 72487 53194 110463614
Product dose omission issue 22.19 13.80 122 72369 321660 110195148
Menstrual disorder 22.07 13.80 21 72470 4763 110512045
Urobilinogen urine increased 21.97 13.80 10 72481 641 110516167
Cerebrovascular accident 21.97 13.80 198 72293 181086 110335722
Hypokalaemia 21.90 13.80 55 72436 182393 110334415
Foot deformity 21.70 13.80 3 72488 48477 110468331
Lower respiratory tract infection 21.61 13.80 84 72407 243022 110273786
Infusion site discomfort 21.55 13.80 14 72477 1823 110514985
Coronary artery disease 21.53 13.80 10 72481 71680 110445128
Poor quality sleep 21.47 13.80 53 72438 28024 110488784
Haematocrit increased 21.43 13.80 21 72470 4938 110511870
Osteonecrosis of jaw 21.43 13.80 3 72488 48014 110468794
Gestational hypertension 21.37 13.80 15 72476 2219 110514589
Underweight 21.31 13.80 13 72478 1517 110515291
Cerebral haemorrhage 21.22 13.80 8 72483 64960 110451848
Drug tolerance decreased 21.08 13.80 52 72439 27488 110489320
Injection site pain 21.07 13.80 54 72437 177868 110338940
Noninfective encephalitis 21.06 13.80 10 72481 706 110516102
Suicide attempt 21.04 13.80 22 72469 103372 110413436
Hepatic cirrhosis 20.99 13.80 9 72482 67617 110449191
Dysmenorrhoea 20.89 13.80 18 72473 3592 110513216
Extensor plantar response 20.76 13.80 14 72477 1941 110514867
Transient ischaemic attack 20.69 13.80 8 72483 63974 110452834
Pneumonia aspiration 20.56 13.80 14 72477 81219 110435589
Urinary casts 20.32 13.80 12 72479 1320 110515488
Injection site extravasation 20.31 13.80 29 72462 10140 110506668
Retinal depigmentation 20.30 13.80 8 72483 358 110516450
Gastrointestinal stoma complication 20.26 13.80 17 72474 3272 110513536
Infected dermal cyst 20.19 13.80 12 72479 1336 110515472
Weight decreased 20.07 13.80 424 72067 467633 110049175
Drug resistance 20.05 13.80 6 72485 56368 110460440
Onychomadesis 20.04 13.80 3 72488 45660 110471148
Neuropathy peripheral 20.03 13.80 56 72435 179221 110337587
Product use issue 20.00 13.80 301 72190 311394 110205414
Hypertonia 19.85 13.80 26 72465 8380 110508428
Aggression 19.83 13.80 7 72484 59203 110457605
Ascites 19.74 13.80 19 72472 92789 110424019
Lipaemic index score 19.66 13.80 6 72485 123 110516685
Aplasia 19.61 13.80 25 72466 7848 110508960
Device loosening 19.52 13.80 10 72481 832 110515976
Extrapyramidal disorder 19.50 13.80 52 72439 28815 110487993
Fumbling 19.22 13.80 6 72485 133 110516675
Tachycardia 19.13 13.80 230 72261 226415 110290393
Flank pain 19.12 13.80 45 72446 23085 110493723
Suicidal ideation 19.10 13.80 20 72471 93917 110422891
Tooth injury 19.01 13.80 14 72477 2232 110514576
Hyperhidrosis 18.97 13.80 197 72294 187101 110329707
Infusion site scar 18.94 13.80 8 72483 428 110516380
Cardiac arrest 18.78 13.80 66 72425 196687 110320121
Red blood cell sedimentation rate increased 18.71 13.80 101 72390 78201 110438607
Therapeutic response shortened 18.69 13.80 52 72439 29531 110487277
Coeliac disease 18.58 13.80 3 72488 43184 110473624
Picornavirus infection 18.57 13.80 6 72485 149 110516659
Hepatitis 18.50 13.80 19 72472 90035 110426773
Mean cell volume increased 18.50 13.80 25 72466 8305 110508503
Maternal exposure during pregnancy 18.48 13.80 95 72396 254788 110262020
Endometrial ablation 18.41 13.80 10 72481 938 110515870
Stoma site pain 18.36 13.80 13 72478 1950 110514858
Disability assessment scale score increased 18.30 13.80 18 72473 4252 110512556
Rales 18.18 13.80 46 72445 24693 110492115
Brain death 18.18 13.80 22 72469 6551 110510257
Limbal swelling 18.17 13.80 4 72487 20 110516788
Infusion site erythema 18.11 13.80 30 72461 11929 110504879
Wound infection 18.02 13.80 22 72469 96443 110420365
Cholestasis 17.88 13.80 10 72481 64508 110452300
Human chorionic gonadotropin decreased 17.84 13.80 5 72486 75 110516733
Thyroid stimulating immunoglobulin 17.78 13.80 5 72486 76 110516732
Cerebral infarction 17.58 13.80 6 72485 51832 110464976
Concussion 17.54 13.80 29 72462 11509 110505299
Eosinophilia 17.52 13.80 8 72483 57928 110458880
Creatinine urine increased 17.50 13.80 8 72483 518 110516290
Urticaria 17.49 13.80 300 72191 318557 110198251
Bone marrow failure 17.48 13.80 8 72483 57840 110458968
Disease recurrence 17.46 13.80 9 72482 60775 110456033
Seizure 17.45 13.80 80 72411 221105 110295703
Sciatica 17.33 13.80 21 72470 92378 110424430
Osteoporosis 17.22 13.80 19 72472 87133 110429675
Pregnancy 17.17 13.80 6 72485 51061 110465747
Productive cough 17.14 13.80 131 72360 114174 110402634
Vertebral lateral recess stenosis 17.12 13.80 7 72484 345 110516463
International normalised ratio increased 17.06 13.80 19 72472 86753 110430055
Prostate examination abnormal 17.04 13.80 6 72485 195 110516613
Blood pressure diastolic decreased 16.98 13.80 57 72434 35828 110480980
Taste disorder 16.91 13.80 11 72480 65376 110451432
Abdominal pain 16.88 13.80 448 72043 512541 110004267
Adverse drug reaction 16.80 13.80 27 72464 105532 110411276
Renal pain 16.74 13.80 26 72465 9791 110507017
Ligamentum flavum hypertrophy 16.69 13.80 7 72484 368 110516440
Blood creatine phosphokinase increased 16.69 13.80 14 72477 73063 110443745
Nasal congestion 16.66 13.80 116 72375 98166 110418642
Arteriovenous fistula 16.65 13.80 11 72480 1474 110515334
Blood glucose increased 16.64 13.80 39 72452 132457 110384351
Infusion site swelling 16.62 13.80 26 72465 9851 110506957
Osteoarthropathy 16.62 13.80 7 72484 372 110516436
Accidental exposure to product 16.60 13.80 6 72485 50002 110466806
Neoplasm progression 16.52 13.80 11 72480 64584 110452224
Tinnitus 16.49 13.80 81 72410 60459 110456349
Staphylococcal infection 16.47 13.80 13 72478 69931 110446877
Cardio-respiratory arrest 16.29 13.80 32 72459 115804 110401004
Obstructive airways disorder 16.26 13.80 5 72486 46144 110470664
Pneumocystis jirovecii pneumonia 16.23 13.80 4 72487 42731 110474077
Clonus 16.16 13.80 24 72467 8692 110508116
Exostosis 16.15 13.80 5 72486 45951 110470857
Infusion site pruritus 15.92 13.80 18 72473 4990 110511818
Hypomagnesaemia 15.82 13.80 10 72481 60360 110456448
Neutrophil percentage decreased 15.72 13.80 9 72482 934 110515874
Malignant neoplasm progression 15.71 13.80 60 72431 174507 110342301
Benign bone neoplasm 15.68 13.80 5 72486 119 110516689
Pulmonary embolism 15.51 13.80 80 72411 214394 110302414
Lower limb fracture 15.36 13.80 16 72475 75332 110441476
Femur fracture 15.34 13.80 5 72486 44464 110472344
Acute respiratory failure 15.32 13.80 16 72475 75244 110441564
Monocyte count abnormal 15.32 13.80 6 72485 264 110516544
Nervousness 15.25 13.80 56 72435 36795 110480013
Vaginal odour 15.21 13.80 7 72484 460 110516348
Dengue fever 15.21 13.80 10 72481 1329 110515479
Thyroid cyst 15.00 13.80 7 72484 475 110516333
Feeding disorder 14.96 13.80 39 72452 21323 110495485
Ear pruritus 14.94 13.80 21 72470 7239 110509569
Hospitalisation 14.84 13.80 46 72445 142447 110374361
Respiratory arrest 14.81 13.80 10 72481 58289 110458519
Loefgren syndrome 14.74 13.80 5 72486 145 110516663
Acute myocardial infarction 14.72 13.80 20 72471 83757 110433051
Basophil count increased 14.68 13.80 11 72480 1799 110515009
Periorbital swelling 14.54 13.80 18 72473 5487 110511321
Sepsis 14.41 13.80 141 72350 327205 110189603
Apallic syndrome 14.40 13.80 9 72482 1097 110515711
Limb discomfort 14.39 13.80 59 72432 40795 110476013
Kidney infection 14.25 13.80 43 72448 25556 110491252
Intracranial aneurysm 14.15 13.80 17 72474 5023 110511785
Thyroid function test abnormal 14.07 13.80 14 72477 3353 110513455
Shock 13.88 13.80 9 72482 53579 110463229
Pneumovirus test positive 13.86 13.80 4 72487 67 110516741
Immature granulocyte count increased 13.81 13.80 8 72483 849 110515959

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R06AA11 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Aminoalkyl ethers
ATC R06AA61 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Aminoalkyl ethers
MeSH PA D000932 Antiemetics
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D018377 Neurotransmitter Agents
CHEBI has role CHEBI:37955 H<small><sub>1</sub></small>-receptor antagonist
CHEBI has role CHEBI:50919 antiemetic

Related Drugs by ATC class:

R06AA Aminoalkyl ethers 8 drugs
bromazinecarbinoxaminechlorphenoxamineclemastinediphenhydraminediphenylpyralinedoxylaminetrimethobenzamide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Nausea and vomiting indication 16932000
Motion sickness indication 37031009 DOID:2951
Prevention of motion sickness indication 37031009 DOID:2951
Vertigo indication 399153001
Vomiting indication 422400008
Nausea indication 422587007
Prevention of Nausea and Vomiting indication
Ménière's disease off-label use 13445001 DOID:9849
Ocular hypertension contraindication 4210003 DOID:9282
Hypophosphatemia contraindication 4996001
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Low blood pressure contraindication 45007003
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Chronic idiopathic constipation contraindication 82934008
Gout contraindication 90560007 DOID:13189
Liver function tests abnormal contraindication 166603001
Arterial hemorrhage contraindication 234003006
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Pyloric obstruction contraindication 244815007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Angle-closure glaucoma contraindication 392291006 DOID:13550
Acute coronary syndrome contraindication 394659003
Disorder of coronary artery contraindication 414024009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST Ki 7.43 DRUG MATRIX CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.31 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.70 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 6.70 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 5.96 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.48 DRUG MATRIX
Alpha-2B adrenergic receptor GPCR Ki 5.60 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 6.96 DRUG MATRIX
Muscarinic acetylcholine receptor M2 GPCR Ki 6.79 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 7.02 DRUG MATRIX
Muscarinic acetylcholine receptor M4 GPCR Ki 7.10 DRUG MATRIX
Muscarinic acetylcholine receptor M5 GPCR Ki 6.64 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.75 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 5.82 DRUG MATRIX
Alpha-2A adrenergic receptor GPCR Ki 5.79 DRUG MATRIX
Alpha-1D adrenergic receptor GPCR Ki 5.85 DRUG MATRIX

External reference:

IDSource
4018048 VUID
N0000146389 NUI
D00520 KEGG_DRUG
151666 RXNORM
4018048 VANDF
C0012381 UMLSCUI
CHEBI:4604 CHEBI
CHEMBL1200406 ChEMBL_ID
DB00985 DRUGBANK_ID
D004111 MESH_DESCRIPTOR_UI
10660 PUBCHEM_CID
61 INN_ID
JB937PER5C UNII
1568 MMSL
4605 MMSL
6646 MMSL
d00861 MMSL
003371 NDDF
387469006 SNOMEDCT_US
81073007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 0363-1980 TABLET 50 mg ORAL OTC Monograph Drug 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 0363-1980 TABLET 50 mg ORAL OTC Monograph Drug 15 sections
Driminate HUMAN OTC DRUG LABEL 1 0904-2051 TABLET 50 mg ORAL OTC Monograph Drug 15 sections
Driminate HUMAN OTC DRUG LABEL 1 0904-2051 TABLET 50 mg ORAL OTC Monograph Drug 15 sections
Driminate HUMAN OTC DRUG LABEL 1 0904-2051 TABLET 50 mg ORAL OTC Monograph Drug 15 sections
Driminate HUMAN OTC DRUG LABEL 1 0904-2051 TABLET 50 mg ORAL OTC Monograph Drug 15 sections
Dimenhydrinate HUMAN OTC DRUG LABEL 1 0904-6772 TABLET 50 mg ORAL OTC Monograph Drug 16 sections
Dimenhydrinate HUMAN OTC DRUG LABEL 1 0924-1007 TABLET 50 mg ORAL OTC monograph final 17 sections
Gravol HUMAN OTC DRUG LABEL 1 10237-940 CAPSULE, LIQUID FILLED 50 mg ORAL OTC MONOGRAPH DRUG 16 sections
Gravol HUMAN OTC DRUG LABEL 1 10237-941 TABLET, COATED 50 mg ORAL OTC MONOGRAPH DRUG 15 sections
Gravol HUMAN OTC DRUG LABEL 1 10237-942 SYRUP 15 mg ORAL OTC MONOGRAPH DRUG 15 sections
Gravol Chewables Motion Sickness Dimenhydrinate HUMAN OTC DRUG LABEL 1 10237-943 TABLET, CHEWABLE 50 mg ORAL OTC MONOGRAPH DRUG 15 sections
Kids Gravol Chewables Motion Sickness Dimenhydrinate HUMAN OTC DRUG LABEL 1 10237-944 TABLET, CHEWABLE 15 mg ORAL OTC MONOGRAPH DRUG 15 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 11673-198 TABLET 50 mg ORAL OTC Monograph Drug 15 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 11673-198 TABLET 50 mg ORAL OTC Monograph Drug 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 11673-354 TABLET 50 mg ORAL OTC Monograph Drug 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 11822-0198 TABLET 50 mg ORAL OTC Monograph Drug 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 11822-0198 TABLET 50 mg ORAL OTC Monograph Drug 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 36800-930 TABLET 50 mg ORAL OTC Monograph Drug 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 36800-930 TABLET 50 mg ORAL OTC Monograph Drug 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 46122-536 TABLET 50 mg ORAL OTC Monograph Drug 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 46122-536 TABLET 50 mg ORAL OTC Monograph Drug 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 49035-981 TABLET 50 mg ORAL OTC Monograph Drug 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 49035-981 TABLET 50 mg ORAL OTC Monograph Drug 15 sections
DIMENHYDRINATE HUMAN OTC DRUG LABEL 1 49483-352 TABLET, FILM COATED 50 mg ORAL OTC monograph final 11 sections
Airmit Ace HUMAN OTC DRUG LABEL 1 49873-802 TABLET 25 mg ORAL OTC Monograph Drug 12 sections
Dramamine Chewable Dimenhydrinate HUMAN OTC DRUG LABEL 1 50269-525 TABLET, CHEWABLE 50 mg ORAL OTC Monograph Drug 15 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 50804-198 TABLET 50 mg ORAL OTC Monograph Drug 15 sections
Motion Sickness HUMAN OTC DRUG LABEL 1 50804-198 TABLET 50 mg ORAL OTC Monograph Drug 15 sections
Motion Sickness Relief HUMAN OTC DRUG LABEL 1 50844-199 TABLET 50 mg ORAL OTC Monograph Drug 15 sections