dimenhydrinate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
N-methylated xanthine derivatives	901	523-87-5

Description:

Molecule	Description
Synonyms: dimenhydrinate andramine chloranautine diamarin diphenhydramine 8-chlorotheophyllinate diphenhydrinate dramamine menhydrinate theohydramine	A drug combination that contains diphenhydramine and theophylline. It is used for treating VERTIGO, MOTION SICKNESS, and NAUSEA associated with PREGNANCY. Molecular weight: 469.97 Formula: C24H28ClN5O3 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

dimenhydrinate
andramine
chloranautine
diamarin
diphenhydramine 8-chlorotheophyllinate
diphenhydrinate
dramamine
menhydrinate
theohydramine

A drug combination that contains diphenhydramine and theophylline. It is used for treating VERTIGO, MOTION SICKNESS, and NAUSEA associated with PREGNANCY.

Molecular weight: 469.97
Formula: C24H28ClN5O3
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
May 31, 1972	FDA	ALRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Urine abnormality	411.55	15.04	157	34934	6081	50563952
Lymphocyte count decreased	319.43	15.04	209	34882	26098	50543935
Urine leukocyte esterase positive	266.23	15.04	93	34998	2790	50567243
White blood cells urine positive	201.00	15.04	86	35005	4492	50565541
Blood urine present	198.66	15.04	119	34972	12714	50557319
Red blood cells urine positive	194.42	15.04	73	35018	2702	50567331
Enthesopathy	181.26	15.04	92	34999	7101	50562932
Urinary sediment present	163.97	15.04	59	35032	1932	50568101
Tongue disorder	159.86	15.04	92	34999	9124	50560909
Blood parathyroid hormone decreased	156.32	15.04	83	35008	7031	50563002
Urine ketone body present	151.27	15.04	58	35033	2275	50567758
Tenosynovitis	148.22	15.04	92	34999	10473	50559560
Red blood cell sedimentation rate	143.17	15.04	63	35028	3523	50566510
Panniculitis	142.48	15.04	83	35008	8420	50561613
Flushing	130.02	15.04	194	34897	66821	50503212
Granuloma skin	128.17	15.04	68	35023	5750	50564283
Skin necrosis	126.16	15.04	84	35007	10783	50559250
Urine analysis abnormal	125.48	15.04	61	35030	4289	50565744
Crystal urine present	122.59	15.04	44	35047	1430	50568603
Red cell distribution width increased	118.72	15.04	74	35017	8485	50561548
Rheumatoid nodule	116.39	15.04	85	35006	12650	50557383
Aplastic anaemia	110.39	15.04	68	35023	7635	50562398
Haemoglobin urine present	106.25	15.04	34	35057	772	50569261
Death	105.35	15.04	47	35044	325332	50244701
Chest discomfort	104.35	15.04	211	34880	92511	50477522
Culture urine positive	101.37	15.04	49	35042	3402	50566631
Alanine aminotransferase abnormal	101.34	15.04	52	35039	4104	50565929
Ulcer	100.96	15.04	95	34996	20105	50549928
Bacterial test positive	97.86	15.04	53	35038	4670	50565363
Tendonitis	92.10	15.04	83	35008	16622	50553411
Neovascularisation	90.92	15.04	32	35059	981	50569052
Eosinophil count increased	87.70	15.04	62	35029	8768	50561265
Fear of injection	85.23	15.04	53	35038	6050	50563983
Lymphocyte percentage decreased	80.50	15.04	39	35052	2721	50567312
Bacterial test	79.46	15.04	30	35061	1127	50568906
Hypercalcaemia	78.93	15.04	89	35002	23263	50546770
Specific gravity urine decreased	78.48	15.04	26	35065	661	50569372
Feeling hot	76.72	15.04	114	34977	39088	50530945
C-reactive protein abnormal	71.11	15.04	92	34999	27717	50542316
Eosinophil percentage increased	70.02	15.04	26	35065	932	50569101
Neutrophil percentage increased	69.05	15.04	35	35056	2692	50567341
Nausea	67.37	15.04	765	34326	704633	49865400
Basal cell carcinoma	67.26	15.04	82	35009	23274	50546759
Drug eruption	64.95	15.04	81	35010	23525	50546508
Monocyte percentage increased	64.35	15.04	25	35066	1016	50569017
Mean cell haemoglobin concentration increased	62.75	15.04	20	35071	448	50569585
Insomnia	62.17	15.04	263	34828	174602	50395431
Infusion site pain	61.56	15.04	58	35033	12288	50557745
Blood creatinine decreased	61.48	15.04	40	35051	4936	50565097
Rash pruritic	59.98	15.04	114	34977	47732	50522301
Urticaria	59.21	15.04	211	34880	129350	50440683
Gangrene	58.67	15.04	38	35053	4654	50565379
Arterial occlusive disease	57.82	15.04	38	35053	4770	50565263
Alveolitis	56.89	15.04	30	35061	2504	50567529
Monocyte count decreased	56.06	15.04	27	35064	1859	50568174
Loss of personal independence in daily activities	55.83	15.04	139	34952	69911	50500122
Body temperature increased	55.47	15.04	87	35004	31254	50538779
Blood uric acid decreased	55.37	15.04	20	35071	662	50569371
Paradoxical drug reaction	54.31	15.04	33	35058	3614	50566419
Poor venous access	54.30	15.04	50	35041	10290	50559743
Completed suicide	53.18	15.04	13	35078	131876	50438157
Red cell distribution width decreased	52.63	15.04	22	35069	1083	50568950
Oropharyngeal pain	51.44	15.04	144	34947	77657	50492376
Alanine aminotransferase increased	51.19	15.04	156	34935	88203	50481830
Oesophageal spasm	51.03	15.04	27	35064	2269	50567764
Heart rate increased	50.11	15.04	142	34949	77108	50492925
Intestinal pseudo-obstruction	49.79	15.04	19	35072	735	50569298
Blood thyroid stimulating hormone increased	49.72	15.04	38	35053	6054	50563979
Blood pressure fluctuation	49.48	15.04	89	35002	35734	50534299
Headache	49.37	15.04	552	34539	505983	50064050
Gastric disorder	48.15	15.04	79	35012	29469	50540564
Drug ineffective	47.82	15.04	353	34738	818980	49751053
Product dose omission issue	47.36	15.04	35	35056	183803	50386230
Protein urine present	47.12	15.04	35	35056	5342	50564691
Mean cell haemoglobin decreased	46.76	15.04	29	35062	3294	50566739
Red blood cell sedimentation rate increased	45.73	15.04	77	35014	29339	50540694
Heart sounds	45.68	15.04	17	35074	613	50569420
Toxicity to various agents	45.66	15.04	48	35043	212451	50357582
Wound	45.54	15.04	9	35082	105785	50464248
Skin ulcer	45.31	15.04	85	35006	35233	50534800
Haematocrit decreased	44.65	15.04	84	35007	34892	50535141
Neutrophil count increased	44.42	15.04	52	35039	14143	50555890
Prolonged expiration	43.45	15.04	17	35074	704	50569329
Creatinine urine decreased	43.25	15.04	12	35079	163	50569870
Red blood cell count decreased	42.87	15.04	81	35010	33754	50536279
Nitrite urine present	42.63	15.04	18	35073	909	50569124
Erythema	42.15	15.04	207	34884	146207	50423826
Joint injury	42.10	15.04	63	35028	21726	50548307
Arteriovenous fistula occlusion	41.92	15.04	14	35077	365	50569668
Hyponatraemia	41.75	15.04	8	35083	96131	50473902
pH urine increased	41.60	15.04	14	35077	374	50569659
Body temperature decreased	41.53	15.04	54	35037	16341	50553692
Acute kidney injury	41.11	15.04	59	35032	227999	50342034
Blue toe syndrome	40.98	15.04	14	35077	392	50569641
Drug interaction	40.77	15.04	47	35044	199574	50370459
Swelling	40.27	15.04	48	35043	200824	50369209
Confusional state	39.93	15.04	42	35049	185886	50384147
Cardiac failure congestive	38.89	15.04	6	35085	84376	50485657
Oesophageal pain	38.28	15.04	24	35067	2778	50567255
Red blood cells urine	37.78	15.04	14	35077	499	50569534
Blood pressure increased	37.44	15.04	187	34904	132945	50437088
Leukocyturia	37.40	15.04	17	35074	1026	50569007
Urine leukocyte esterase	36.96	15.04	10	35081	123	50569910
Specific gravity urine increased	36.72	15.04	11	35080	199	50569834
C-reactive protein increased	36.30	15.04	115	34976	66359	50503674
Heart rate decreased	36.28	15.04	79	35012	36418	50533615
Blood thyroid stimulating hormone decreased	36.21	15.04	27	35064	4145	50565888
Multiple sclerosis relapse	36.07	15.04	87	35004	42877	50527156
Stress	35.97	15.04	100	34991	53693	50516340
Thrombocytopenia	35.96	15.04	22	35069	127651	50442382
Bradycardia	35.68	15.04	112	34979	64314	50505719
Blood pressure systolic increased	35.54	15.04	77	35014	35372	50534661
Myelocyte count increased	34.95	15.04	12	35079	341	50569692
Oedema peripheral	34.68	15.04	35	35056	157926	50412107
Granuloma	34.67	15.04	28	35063	4830	50565203
Injection site pain	34.36	15.04	17	35074	111007	50459026
Chills	33.21	15.04	144	34947	96543	50473490
Psoriatic arthropathy	33.01	15.04	89	35002	46943	50523090
Mean cell haemoglobin increased	32.83	15.04	20	35071	2200	50567833
Tri-iodothyronine free decreased	32.50	15.04	11	35080	299	50569734
Red blood cell count increased	32.14	15.04	21	35070	2610	50567423
Impaired healing	32.07	15.04	5	35086	69781	50500252
Thyroxine free increased	31.74	15.04	14	35077	787	50569246
Inflammation	31.57	15.04	99	34992	56813	50513220
Mean cell haemoglobin concentration decreased	30.55	15.04	21	35070	2838	50567195
Alopecia	30.54	15.04	79	35012	244968	50325065
Migraine	30.50	15.04	118	34973	75162	50494871
CFTR gene mutation	30.46	15.04	8	35083	87	50569946
Band sensation	30.41	15.04	13	35078	677	50569356
Tachycardia	30.10	15.04	143	34948	99620	50470413
Crystalluria	30.06	15.04	11	35080	378	50569655
Angina pectoris	29.89	15.04	60	35031	26128	50543905
Mean cell volume decreased	29.73	15.04	20	35071	2609	50567424
Neuropathy peripheral	29.66	15.04	15	35076	96742	50473291
Paranasal cyst	29.00	15.04	10	35081	288	50569745
Aspartate aminotransferase increased	28.98	15.04	119	34972	77879	50492154
Vascular malformation	28.84	15.04	10	35081	293	50569740
Band neutrophil percentage increased	27.81	15.04	9	35082	212	50569821
Disease progression	27.72	15.04	16	35075	95850	50474183
Monocyte count increased	27.57	15.04	26	35065	5513	50564520
Urinary retention	27.53	15.04	58	35033	26132	50543901
Anaemia	27.34	15.04	87	35004	252369	50317664
Throat irritation	27.30	15.04	63	35028	30176	50539857
Urine oxalate increased	27.19	15.04	9	35082	228	50569805
Drug ineffective for unapproved indication	27.02	15.04	51	35040	21230	50548803
Gingival bleeding	26.61	15.04	36	35055	11317	50558716
Rhinorrhoea	26.13	15.04	87	35004	51496	50518537
Bulimia nervosa	25.96	15.04	10	35081	397	50569636
Infection	25.39	15.04	51	35040	172903	50397130
Renal failure	25.31	15.04	22	35069	106611	50463422
Cough	25.26	15.04	267	34824	240997	50329036
Mastoiditis	24.92	15.04	12	35079	826	50569207
Pericarditis	24.42	15.04	12	35079	78677	50491356
Infusion site discomfort	24.38	15.04	12	35079	866	50569167
Injection site extravasation	24.34	15.04	28	35063	7473	50562560
Myelocyte percentage increased	24.05	15.04	8	35083	206	50569827
Drug abuse	23.91	15.04	6	35085	59840	50510193
Band neutrophil count increased	23.74	15.04	9	35082	342	50569691
Thyroid disorder	23.56	15.04	36	35055	12641	50557392
Renal pain	23.53	15.04	24	35067	5595	50564438
Infusion related reaction	23.39	15.04	199	34892	169358	50400675
Mean cell volume increased	23.08	15.04	18	35073	2954	50567079
Seizure	22.73	15.04	29	35062	117845	50452188
Teratoma benign	22.70	15.04	6	35085	67	50569966
Extrapyramidal disorder	22.69	15.04	34	35057	11736	50558297
Infusion site extravasation	22.57	15.04	26	35065	6950	50563083
Dizziness	22.52	15.04	351	34740	346018	50224015
Anuria	22.42	15.04	33	35058	11211	50558822
Abdominal pain	22.23	15.04	256	34835	235972	50334061
Drug tolerance	22.21	15.04	22	35069	4954	50565079
Myocardial reperfusion injury	22.11	15.04	5	35086	27	50570006
Depressive symptom	21.90	15.04	18	35073	3182	50566851
Retinal depigmentation	21.89	15.04	8	35083	274	50569759
Immune thrombocytopenia	21.75	15.04	29	35062	8988	50561045
Cardiac failure	21.55	15.04	13	35078	76027	50494006
Poor quality sleep	21.27	15.04	40	35051	16606	50553427
Irritable bowel syndrome	20.86	15.04	5	35086	51436	50518597
Infusion site scar	20.52	15.04	8	35083	328	50569705
Osteoarthritis	20.48	15.04	11	35080	68595	50501438
Creatinine urine increased	20.39	15.04	7	35084	199	50569834
Multiple organ dysfunction syndrome	20.20	15.04	5	35086	50332	50519701
Lip pruritus	20.17	15.04	10	35081	733	50569300
Palpitations	20.03	15.04	123	34968	94383	50475650
Brain death	19.78	15.04	16	35075	2767	50567266
Cerebrovascular accident	19.63	15.04	22	35069	94658	50475375
Rales	19.48	15.04	29	35062	9949	50560084
Urobilinogen urine increased	19.40	15.04	7	35084	231	50569802
Rheumatoid lung	19.29	15.04	15	35076	2450	50567583
Maternal exposure during pregnancy	18.76	15.04	53	35038	159725	50410308
Feeling abnormal	18.75	15.04	150	34941	125342	50444691
Gestational hypertension	18.72	15.04	14	35077	2159	50567874
Influenza	18.63	15.04	116	34975	89422	50480611
Fumbling	18.59	15.04	6	35085	140	50569893
Lymphoedema	18.52	15.04	27	35064	9095	50560938
Hypoglycaemia	18.48	15.04	7	35084	53574	50516459
Gastrointestinal disorder	18.45	15.04	23	35068	94433	50475600
Drug tolerance decreased	18.43	15.04	27	35064	9133	50560900
Thyroid stimulating immunoglobulin	18.29	15.04	5	35086	64	50569969
Interstitial lung disease	18.26	15.04	7	35084	53169	50516864
Limbal swelling	18.12	15.04	4	35087	19	50570014
Klebsiella test positive	18.05	15.04	10	35081	921	50569112
Arthritis	17.83	15.04	112	34979	86609	50483424
Vaginal discharge	17.75	15.04	20	35071	5220	50564813
Skin papilloma	17.60	15.04	18	35073	4211	50565822
Vitamin B12 decreased	17.54	15.04	15	35076	2800	50567233
Rhabdomyolysis	17.47	15.04	3	35088	39024	50531009
Ill-defined disorder	17.47	15.04	8	35083	54646	50515387
Colitis microscopic	17.34	15.04	22	35069	6498	50563535
Septic shock	17.32	15.04	9	35082	57166	50512867
Nasopharyngitis	17.22	15.04	207	34884	192720	50377313
Coma	17.16	15.04	9	35082	56870	50513163
Lipaemic index score	17.09	15.04	5	35086	83	50569950
Appetite disorder	16.85	15.04	21	35070	6093	50563940
Therapy non-responder	16.75	15.04	75	35016	50947	50519086
Dry throat	16.72	15.04	20	35071	5564	50564469
Thirst	16.71	15.04	28	35063	10622	50559411
Immature granulocyte count increased	16.66	15.04	7	35084	349	50569684
Angioedema	16.64	15.04	3	35088	37673	50532360
Injection site reaction	16.50	15.04	7	35084	50025	50520008
Respiration abnormal	16.48	15.04	19	35072	5083	50564950
Wrong technique in product usage process	16.43	15.04	9	35082	55501	50514532
Thyroid cyst	16.42	15.04	8	35083	565	50569468
Gastrointestinal haemorrhage	16.36	15.04	16	35075	73305	50496728
Allergic sinusitis	16.34	15.04	8	35083	571	50569462
Basophil count increased	16.30	15.04	9	35082	823	50569210
Blood cholesterol increased	16.27	15.04	9	35082	55206	50514827
Productive cough	16.22	15.04	76	35015	52618	50517415
Vertigo	16.13	15.04	75	35016	51757	50518276
Injection site bruising	16.08	15.04	3	35088	36765	50533268
Dyspepsia	16.05	15.04	97	34994	74000	50496033
Heart rate irregular	16.03	15.04	39	35052	19321	50550712
Blood luteinising hormone decreased	16.01	15.04	4	35087	35	50569998
Endometrial ablation	16.00	15.04	9	35082	854	50569179
Injection site erythema	15.99	15.04	17	35074	74919	50495114
Suicide attempt	15.88	15.04	8	35083	51724	50518309
Breast cancer	15.83	15.04	5	35086	42885	50527148
Large intestinal ulcer haemorrhage	15.77	15.04	5	35086	110	50569923
Pain	15.72	15.04	295	34796	578608	49991425
Infusion site swelling	15.68	15.04	22	35069	7154	50562879
Tinnitus	15.65	15.04	49	35042	28083	50541950
Hypokalaemia	15.60	15.04	23	35068	87969	50482064
Cardio-respiratory arrest	15.57	15.04	9	35082	53883	50516150
Decerebrate posture	15.44	15.04	5	35086	118	50569915
Haematocrit increased	15.42	15.04	12	35079	1962	50568071
Chronic gastrointestinal bleeding	15.36	15.04	5	35086	120	50569913
Menstrual disorder	15.35	15.04	17	35074	4353	50565680
Urinary casts	15.31	15.04	8	35083	655	50569378
Metabolic acidosis	15.30	15.04	4	35087	38821	50531212
Deep vein thrombosis	15.23	15.04	17	35074	73287	50496746

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Aplastic anaemia	200.82	17.57	79	9240	7431	29557777
Tenosynovitis	146.34	17.57	52	9267	3681	29561527
Enthesopathy	146.20	17.57	52	9267	3691	29561517
C-reactive protein abnormal	114.87	17.57	51	9268	6485	29558723
Tongue disorder	114.25	17.57	46	9273	4590	29560618
Victim of child abuse	112.05	17.57	30	9289	815	29564393
Synovitis	92.91	17.57	52	9267	10838	29554370
Alanine aminotransferase abnormal	92.91	17.57	35	9284	2922	29562286
Tendonitis	90.42	17.57	46	9273	7915	29557293
Respiratory depression	84.99	17.57	53	9266	13470	29551738
Erythema	77.93	17.57	107	9212	75499	29489709
Epidural lipomatosis	74.60	17.57	21	9298	690	29564518
Psoriatic arthropathy	71.35	17.57	49	9270	14642	29550566
Drug dependence	68.26	17.57	55	9264	20926	29544282
Febrile neutropenia	67.35	17.57	124	9195	112116	29453092
Loss of personal independence in daily activities	61.00	17.57	56	9263	25384	29539824
Foetal exposure during pregnancy	50.98	17.57	58	9261	33809	29531399
Product prescribing error	49.90	17.57	43	9276	17933	29547275
Platelet transfusion	49.33	17.57	17	9302	1097	29564111
Aspartate aminotransferase increased	46.30	17.57	74	9245	59651	29505557
Lymphocyte percentage decreased	46.21	17.57	19	9300	1998	29563210
Heart rate irregular	46.11	17.57	36	9283	13081	29552127
Urine abnormality	45.88	17.57	18	9301	1676	29563532
Juvenile idiopathic arthritis	45.60	17.57	17	9302	1377	29563831
Nausea	45.04	17.57	195	9124	289060	29276148
Blood pressure fluctuation	44.23	17.57	42	9277	19852	29545356
Alanine aminotransferase increased	43.26	17.57	79	9240	70865	29494343
Red blood cell sedimentation rate	43.22	17.57	13	9306	541	29564667
Mucosal inflammation	42.36	17.57	51	9268	31544	29533664
Granuloma skin	41.21	17.57	13	9306	635	29564573
Treatment failure	40.60	17.57	54	9265	36885	29528323
Death	39.75	17.57	30	9289	342054	29223154
Blood parathyroid hormone decreased	38.14	17.57	13	9306	811	29564397
Lymphocyte count decreased	37.81	17.57	38	9281	19233	29545975
Neutrophil percentage increased	34.86	17.57	15	9304	1766	29563442
Panniculitis	33.16	17.57	13	9306	1208	29564000
C-reactive protein increased	33.13	17.57	54	9265	44209	29520999
Congenital skin dimples	31.97	17.57	8	9311	165	29565043
Transfusion	30.00	17.57	22	9297	7276	29557932
Product use issue	28.48	17.57	55	9264	51389	29513819
Off label use	27.44	17.57	175	9144	300625	29264583
Epispadias	27.37	17.57	7	9312	158	29565050
pH urine increased	26.79	17.57	6	9313	75	29565133
Inappropriate schedule of product administration	26.42	17.57	49	9270	44423	29520785
Rheumatoid nodule	26.25	17.57	13	9306	2109	29563099
Drug hypersensitivity	26.22	17.57	63	9256	68343	29496865
Vomiting	24.85	17.57	132	9187	212128	29353080
Drug intolerance	24.70	17.57	50	9269	48329	29516879
Drug interaction	24.59	17.57	16	9303	197369	29367839
Headache	24.46	17.57	114	9205	173893	29391315
Contraindicated product administered	23.68	17.57	29	9290	18237	29546971
White blood cells urine positive	23.35	17.57	10	9309	1164	29564044
Specific gravity urine increased	23.23	17.57	6	9313	141	29565067
Urine leukocyte esterase positive	21.16	17.57	7	9312	398	29564810
Urine ketone body present	21.08	17.57	9	9310	1039	29564169
Red blood cell elliptocytes present	20.62	17.57	5	9314	90	29565118
Child abuse	20.55	17.57	6	9313	225	29564983
Pyloric stenosis	20.42	17.57	8	9311	742	29564466
Band neutrophil percentage increased	19.85	17.57	5	9314	106	29565102
Umbilical hernia	19.41	17.57	13	9306	3722	29561486
Congenital umbilical hernia	19.14	17.57	6	9313	287	29564921
Infusion related reaction	18.53	17.57	42	9277	43844	29521364
Obesity	18.52	17.57	19	9300	9844	29555364
Restrictive cardiomyopathy	18.46	17.57	7	9312	594	29564614
Aplasia	18.42	17.57	13	9306	4050	29561158
Heart rate decreased	18.10	17.57	30	9289	24882	29540326
Neutrophil percentage decreased	18.04	17.57	6	9313	347	29564861
Hypercalcaemia	17.75	17.57	21	9298	12738	29552470

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Urine abnormality	453.99	13.93	174	42350	7188	64449020
Lymphocyte count decreased	326.46	13.93	246	42278	40453	64415755
Enthesopathy	302.62	13.93	141	42383	9497	64446711
Urine leukocyte esterase positive	278.27	13.93	99	42425	3304	64452904
Tenosynovitis	275.13	13.93	141	42383	11692	64444516
Aplastic anaemia	264.59	13.93	145	42379	13775	64442433
Tongue disorder	260.93	13.93	137	42387	11943	64444265
White blood cells urine positive	223.97	13.93	96	42428	5302	64450906
Blood parathyroid hormone decreased	195.42	13.93	96	42428	7270	64448938
Red blood cell sedimentation rate	187.59	13.93	76	42448	3638	64452570
Blood urine present	183.91	13.93	127	42397	18213	64437995
Red blood cells urine positive	180.40	13.93	78	42446	4400	64451808
Panniculitis	178.48	13.93	96	42428	8783	64447425
Tendonitis	174.66	13.93	128	42396	20154	64436054
Alanine aminotransferase abnormal	174.51	13.93	87	42437	6801	64449407
Granuloma skin	166.64	13.93	81	42443	5993	64450215
Urine ketone body present	164.72	13.93	67	42457	3240	64452968
Urinary sediment present	160.24	13.93	59	42465	2175	64454033
C-reactive protein abnormal	157.83	13.93	140	42384	28907	64427301
Death	153.98	13.93	63	42461	482642	63973566
Rheumatoid nodule	151.89	13.93	98	42426	12553	64443655
Skin necrosis	138.45	13.93	97	42427	14232	64441976
Urine analysis abnormal	132.08	13.93	68	42456	5688	64450520
Flushing	131.69	13.93	207	42317	78441	64377767
Crystal urine present	131.22	13.93	49	42475	1880	64454328
Red cell distribution width increased	127.57	13.93	87	42437	12222	64443986
Loss of personal independence in daily activities	120.33	13.93	190	42334	72264	64383944
Nausea	120.25	13.93	906	41618	784894	63671314
Lymphocyte percentage decreased	115.64	13.93	58	42466	4591	64451617
Ulcer	111.55	13.93	104	42420	22886	64433322
Chest discomfort	111.12	13.93	240	42284	115866	64340342
Psoriatic arthropathy	106.61	13.93	137	42387	43144	64413064
Drug interaction	97.64	13.93	59	42465	362024	64094184
Haemoglobin urine present	97.53	13.93	32	42492	831	64455377
Headache	96.81	13.93	638	41886	528829	63927379
Erythema	96.70	13.93	307	42217	186763	64269445
Culture urine positive	95.13	13.93	49	42475	4102	64452106
Neutrophil percentage increased	94.80	13.93	50	42474	4395	64451813
Hypercalcaemia	92.81	13.93	109	42415	31307	64424901
Acute kidney injury	92.50	13.93	96	42428	449144	64007064
Fear of injection	91.87	13.93	54	42470	5858	64450350
Eosinophil count increased	90.88	13.93	75	42449	14037	64442171
Bacterial test positive	90.76	13.93	56	42468	6634	64449574
Bacterial test	90.73	13.93	33	42491	1174	64455034
Toxicity to various agents	90.21	13.93	65	42459	363448	64092760
Completed suicide	90.16	13.93	19	42505	224395	64231813
Neovascularisation	89.84	13.93	32	42492	1071	64455137
Victim of child abuse	89.26	13.93	30	42494	841	64455367
Specific gravity urine decreased	88.35	13.93	29	42495	754	64455454
Eosinophil percentage increased	81.87	13.93	32	42492	1392	64454816
Insomnia	79.81	13.93	299	42225	197537	64258671
Basal cell carcinoma	78.12	13.93	99	42425	30739	64425469
Blood pressure fluctuation	77.90	13.93	130	42394	51741	64404467
Feeling hot	77.52	13.93	121	42403	45542	64410666
Alanine aminotransferase increased	72.56	13.93	229	42295	138802	64317406
Monocyte percentage increased	71.38	13.93	32	42492	1968	64454240
Infusion site pain	70.62	13.93	57	42467	10340	64445868
Urticaria	69.99	13.93	235	42289	147082	64309126
Rash pruritic	69.61	13.93	131	42393	57273	64398935
Drug eruption	63.08	13.93	97	42427	36039	64420169
Poor venous access	61.83	13.93	57	42467	12360	64443848
Mean cell haemoglobin concentration increased	60.96	13.93	22	42502	765	64455443
Red cell distribution width decreased	60.86	13.93	24	42500	1069	64455139
Body temperature increased	60.63	13.93	96	42428	36570	64419638
Multiple sclerosis relapse	60.31	13.93	102	42422	41033	64415175
Anaemia	59.36	13.93	99	42425	378581	64077627
Monocyte count decreased	57.72	13.93	31	42493	2826	64453382
Gastric disorder	57.59	13.93	83	42441	29114	64427094
Oropharyngeal pain	56.46	13.93	157	42367	88710	64367498
Oesophageal spasm	55.55	13.93	29	42495	2496	64453712
Blood creatinine decreased	55.12	13.93	42	42482	7008	64449200
Epidural lipomatosis	55.02	13.93	21	42503	856	64455352
Migraine	54.77	13.93	125	42399	62552	64393656
Infusion related reaction	54.61	13.93	234	42290	164233	64291975
Hyperkalaemia	54.42	13.93	3	42521	101126	64355082
Blood uric acid decreased	53.69	13.93	22	42502	1084	64455124
C-reactive protein increased	52.90	13.93	160	42364	94749	64361459
Skin ulcer	52.87	13.93	100	42424	43874	64412334
pH urine increased	52.73	13.93	17	42507	417	64455791
Aspartate aminotransferase increased	52.44	13.93	186	42338	119602	64336606
Protein urine present	52.31	13.93	45	42479	8911	64447297
Specific gravity urine increased	52.27	13.93	17	42507	429	64455779
Hyponatraemia	51.13	13.93	17	42507	148322	64307886
Synovitis	49.65	13.93	161	42363	98929	64357279
Red blood cell sedimentation rate increased	49.20	13.93	80	42444	31155	64425053
Arterial occlusive disease	48.70	13.93	39	42485	6994	64449214
Cardiac failure congestive	48.58	13.93	13	42511	130567	64325641
Heart rate irregular	48.42	13.93	74	42450	27339	64428869
Alveolitis	47.79	13.93	30	42494	3662	64452546
Mean cell haemoglobin decreased	47.19	13.93	31	42493	4091	64452117
Confusional state	46.99	13.93	62	42462	261082	64195126
Renal failure	46.98	13.93	31	42493	181657	64274551
Heart rate decreased	46.10	13.93	108	42416	54959	64401249
Blood thyroid stimulating hormone increased	45.81	13.93	39	42485	7615	64448593
Body temperature decreased	45.81	13.93	70	42454	25858	64430350
Treatment failure	45.76	13.93	175	42349	116641	64339567
Heart rate increased	45.59	13.93	156	42368	98519	64357689
Gangrene	45.17	13.93	38	42486	7300	64448908
Oedema peripheral	44.26	13.93	44	42480	210273	64245935
Nitrite urine present	44.25	13.93	19	42505	1053	64455155
Blue toe syndrome	44.18	13.93	16	42508	562	64455646
Heart sounds	43.52	13.93	16	42508	587	64455621
Joint injury	43.46	13.93	64	42460	22883	64433325
Oesophageal pain	43.46	13.93	27	42497	3236	64452972
Product dose omission issue	43.02	13.93	39	42485	194708	64261500
Mean cell haemoglobin concentration decreased	42.89	13.93	28	42496	3656	64452552
Red blood cell count decreased	42.82	13.93	97	42427	48289	64407919
Blood thyroid stimulating hormone decreased	42.75	13.93	32	42492	5198	64451010
Band neutrophil percentage increased	41.80	13.93	14	42510	388	64455820
Cardiac failure	40.91	13.93	18	42506	132355	64323853
Creatinine urine decreased	40.82	13.93	12	42512	214	64455994
Paradoxical drug reaction	40.40	13.93	33	42491	6087	64450121
Disease progression	39.66	13.93	22	42502	141658	64314550
Haematocrit decreased	39.18	13.93	101	42423	54554	64401654
Inflammation	39.15	13.93	113	42411	65187	64391021
Febrile neutropenia	38.99	13.93	234	42290	187423	64268785
Prolonged expiration	38.69	13.93	16	42508	807	64455401
Red blood cells urine	38.61	13.93	15	42509	642	64455566
Band sensation	38.34	13.93	15	42509	654	64455554
Blood pressure systolic increased	38.18	13.93	94	42430	49359	64406849
Interstitial lung disease	37.76	13.93	9	42515	97723	64358485
Arteriovenous fistula occlusion	37.54	13.93	14	42510	535	64455673
Red blood cell count increased	36.53	13.93	25	42499	3530	64452678
Gastrointestinal haemorrhage	36.38	13.93	21	42503	132291	64323917
Blood pressure increased	36.38	13.93	216	42308	172336	64283872
Intestinal pseudo-obstruction	35.71	13.93	20	42504	1980	64454228
Stress	35.57	13.93	104	42420	60430	64395778
Urine leukocyte esterase	35.32	13.93	10	42514	155	64456053
Band neutrophil count increased	35.14	13.93	14	42510	641	64455567
Leukocyturia	34.79	13.93	18	42506	1520	64454688
Platelet transfusion	34.77	13.93	19	42505	1792	64454416
Cardio-respiratory arrest	34.39	13.93	11	42513	98382	64357826
Multiple organ dysfunction syndrome	34.28	13.93	12	42512	101401	64354807
Mean cell haemoglobin increased	34.05	13.93	23	42501	3179	64453029
Renal impairment	33.61	13.93	24	42500	134993	64321215
Infusion site extravasation	33.29	13.93	31	42493	6806	64449402
Inappropriate schedule of product administration	32.70	13.93	134	42390	92152	64364056
Rhabdomyolysis	32.51	13.93	10	42514	91716	64364492
Mean cell volume decreased	32.16	13.93	23	42501	3483	64452725
Throat irritation	31.68	13.93	68	42456	32643	64423565
Tri-iodothyronine free decreased	31.41	13.93	11	42513	350	64455858
Respiratory failure	31.36	13.93	36	42488	161147	64295061
Red blood cell elliptocytes present	31.35	13.93	9	42515	147	64456061
Transfusion	30.97	13.93	48	42476	17946	64438262
Product use issue	30.75	13.93	188	42336	151527	64304681
Respiratory depression	30.29	13.93	55	42469	23388	64432820
Granuloma	30.21	13.93	29	42495	6612	64449596
Neutrophil count increased	29.94	13.93	57	42467	25117	64431091
Vascular malformation	29.37	13.93	10	42514	292	64455916
Cardiac arrest	29.34	13.93	35	42489	154029	64302179
Monocyte count increased	28.93	13.93	31	42493	8048	64448160
Septic shock	28.61	13.93	17	42507	105420	64350788
Coma	28.55	13.93	11	42513	87604	64368604
Palpitations	28.23	13.93	140	42384	104348	64351860
Paranasal cyst	28.09	13.93	10	42514	334	64455874
Thyroxine free increased	28.09	13.93	14	42510	1093	64455115
Urine oxalate increased	27.90	13.93	9	42515	221	64455987
Drug tolerance decreased	27.11	13.93	28	42496	6970	64449238
CFTR gene mutation	27.02	13.93	7	42517	76	64456132
Myelocyte count increased	26.74	13.93	12	42512	740	64455468
Infusion site discomfort	26.52	13.93	12	42512	754	64455454
Drug dependence	26.43	13.93	64	42460	33248	64422960
Haematocrit increased	26.31	13.93	20	42504	3325	64452883
Therapy non-responder	26.02	13.93	99	42425	65800	64390408
Wound	25.93	13.93	9	42515	76468	64379740
Neuropathy peripheral	25.39	13.93	24	42500	117501	64338707
Fatigue	25.36	13.93	659	41865	748071	63708137
Nasopharyngitis	25.29	13.93	218	42306	195855	64260353
Rhinorrhoea	25.27	13.93	92	42432	59877	64396331
Chronic kidney disease	25.18	13.93	4	42520	57915	64398293
Lactic acidosis	25.05	13.93	5	42519	61405	64394803
Mental status changes	24.90	13.93	5	42519	61157	64395051
Thrombocytopenia	24.69	13.93	71	42453	223730	64232478
Tachycardia	24.63	13.93	176	42348	149403	64306805
Seizure	23.96	13.93	46	42478	166846	64289362
Lymphoedema	23.82	13.93	31	42493	9874	64446334
Injection site extravasation	23.78	13.93	28	42496	8058	64448150
Abdominal pain	23.68	13.93	312	42212	312063	64144145
Myelocyte percentage increased	23.19	13.93	8	42516	243	64455965
Arthritis	23.13	13.93	113	42411	83701	64372507
Rheumatoid arthritis	22.95	13.93	186	42338	164108	64292100
Chills	22.89	13.93	162	42362	137102	64319106
Infusion site scar	22.77	13.93	8	42516	257	64455951
Poor quality sleep	22.65	13.93	43	42481	18908	64437300
Gestational hypertension	22.62	13.93	14	42510	1667	64454541
Crystalluria	22.46	13.93	11	42513	827	64455381
Cerebrovascular accident	22.41	13.93	35	42489	137548	64318660
Myocardial reperfusion injury	22.36	13.93	5	42519	27	64456181
Hypoglycaemia	22.34	13.93	16	42508	89876	64366332
Pneumonia	22.21	13.93	249	42275	559327	63896881
Influenza	22.20	13.93	133	42391	106398	64349810
Cough	22.16	13.93	300	42224	301848	64154360
Rheumatoid lung	22.14	13.93	16	42508	2463	64453745
Deep vein thrombosis	22.12	13.93	22	42502	105160	64351048
Feeling abnormal	21.88	13.93	157	42367	133445	64322763
Feeling cold	21.54	13.93	48	42476	23630	64432578
Injection site pain	21.54	13.93	25	42499	111383	64344825
Angioedema	21.44	13.93	7	42517	61814	64394394
Dyspepsia	21.26	13.93	107	42417	80205	64376003
Retinal depigmentation	21.25	13.93	8	42516	314	64455894
Drug tolerance	21.18	13.93	23	42501	6062	64450146
Vaginal discharge	21.17	13.93	19	42505	3978	64452230
Mean cell volume increased	21.02	13.93	21	42503	5025	64451183
Orthostatic hypotension	20.84	13.93	3	42521	46735	64409473
Acute myocardial infarction	20.73	13.93	10	42514	69708	64386500
Coronary artery disease	20.68	13.93	7	42517	60426	64395782
Gingival bleeding	20.67	13.93	36	42488	14818	64441390
Diabetes mellitus	20.59	13.93	9	42515	66465	64389743
Respiration abnormal	20.48	13.93	23	42501	6292	64449916
Respiratory arrest	20.22	13.93	5	42519	52980	64403228
Therapeutic response shortened	20.18	13.93	29	42495	10141	64446067
Pneumonia aspiration	20.05	13.93	7	42517	59264	64396944
Menstrual disorder	19.84	13.93	17	42507	3348	64452860
Wrong technique in product usage process	19.81	13.93	9	42515	64965	64391243
Infusion site swelling	19.62	13.93	21	42503	5444	64450764
Mastoiditis	19.36	13.93	12	42512	1433	64454775
Bone marrow failure	19.35	13.93	4	42520	47948	64408260
Fumbling	19.18	13.93	6	42518	133	64456075
Cerebral haemorrhage	19.16	13.93	5	42519	51085	64405123
Creatinine urine increased	19.11	13.93	8	42516	416	64455792
Suicidal ideation	19.10	13.93	10	42514	66532	64389676
Urobilinogen urine increased	19.07	13.93	9	42515	623	64455585
Lipaemic index score	19.06	13.93	6	42518	136	64456072
Haematuria	19.03	13.93	8	42516	60463	64395745
Infusion site erythema	18.90	13.93	23	42501	6850	64449358
Renal pain	18.63	13.93	23	42501	6951	64449257
Pancreatitis acute	18.53	13.93	3	42521	42852	64413356
International normalised ratio increased	18.51	13.93	15	42509	79152	64377056
Thyroid disorder	18.48	13.93	30	42494	11662	64444546
Aggression	18.37	13.93	4	42520	46228	64409980
Thyroid stimulating immunoglobulin	18.27	13.93	5	42519	68	64456140
Limbal swelling	18.15	13.93	4	42520	20	64456188
Lip pruritus	18.14	13.93	9	42515	696	64455512
Syncope	18.12	13.93	49	42475	157586	64298622
Neutrophil percentage decreased	17.77	13.93	9	42515	727	64455481
Juvenile idiopathic arthritis	17.76	13.93	17	42507	3862	64452346
Sepsis	17.59	13.93	85	42439	230256	64225952
Klebsiella test positive	17.40	13.93	11	42513	1359	64454849
Mean platelet volume decreased	17.38	13.93	12	42512	1719	64454489
Pulmonary embolism	17.20	13.93	45	42479	146311	64309897
Suicide attempt	17.17	13.93	13	42511	70994	64385214
Metabolic acidosis	17.15	13.93	13	42511	70945	64385263
Hypokalaemia	17.15	13.93	34	42490	121869	64334339
Endometrial ablation	17.05	13.93	9	42515	792	64455416
Skin papilloma	16.96	13.93	19	42505	5184	64451024
Drug abuse	16.89	13.93	39	42485	132335	64323873
Drug ineffective for unapproved indication	16.87	13.93	52	42472	31081	64425127
Osteonecrosis of jaw	16.76	13.93	3	42521	39822	64416386
Peripheral swelling	16.71	13.93	211	42313	208942	64247266
Vitamin B12 decreased	16.59	13.93	14	42510	2701	64453507
Hepatic function abnormal	16.57	13.93	11	42513	64302	64391906
Child abuse	16.48	13.93	6	42518	214	64455994
Oedema	16.33	13.93	22	42502	91913	64364295
Rales	16.31	13.93	33	42491	15196	64441012
Hyperglycaemia	16.30	13.93	10	42514	60958	64395250
Acute respiratory distress syndrome	16.24	13.93	3	42521	38932	64417276
Dizziness	16.10	13.93	384	42140	429779	64026429
Osteoarthritis	16.10	13.93	11	42513	63325	64392883
Impaired healing	16.05	13.93	10	42514	60463	64395745
Drug intolerance	16.03	13.93	192	42332	187800	64268408
Dry throat	15.76	13.93	20	42504	6212	64449996
Depressive symptom	15.66	13.93	17	42507	4479	64451729
Sedation	15.66	13.93	4	42520	41458	64414750
Staphylococcal infection	15.48	13.93	7	42517	50671	64405537
Swelling	15.43	13.93	54	42470	160164	64296044
Basophil count increased	15.43	13.93	10	42514	1290	64454918
General physical health deterioration	15.39	13.93	204	42320	204221	64251987
Transient ischaemic attack	15.33	13.93	5	42519	44177	64412031
Appetite disorder	15.19	13.93	20	42504	6441	64449767
White blood cell count decreased	15.16	13.93	165	42359	157672	64298536
Infusion site pruritus	15.03	13.93	13	42511	2593	64453615
Allergic sinusitis	15.02	13.93	7	42517	471	64455737
Injection site reaction	14.97	13.93	6	42518	46658	64409550
Immature granulocyte count increased	14.91	13.93	7	42517	479	64455729
Injection site bruising	14.75	13.93	3	42521	36370	64419838
Haematoma	14.75	13.93	6	42518	46244	64409964
Anuria	14.58	13.93	36	42488	18928	64437280
Change in seizure presentation	14.54	13.93	6	42518	301	64455907
Serotonin syndrome	14.43	13.93	4	42520	39278	64416930
COVID-19	14.42	13.93	13	42511	65127	64391081
Pericarditis	14.42	13.93	12	42512	62504	64393704
Cystitis	14.35	13.93	61	42463	42614	64413594
Infusion site rash	14.35	13.93	9	42515	1097	64455111
Drug reaction with eosinophilia and systemic symptoms	14.34	13.93	9	42515	54208	64402000
Immune thrombocytopenia	14.22	13.93	31	42493	15035	64441173
Drug ineffective	14.22	13.93	434	42090	839813	63616395
Off label use	14.18	13.93	530	41994	632276	63823932
Rash	14.14	13.93	399	42125	458150	63998058
Tinnitus	14.07	13.93	52	42472	34081	64422127
Aplasia	14.05	13.93	20	42504	6933	64449275
Bradycardia	13.97	13.93	129	42395	118090	64338118
Infusion site bruising	13.94	13.93	10	42514	1522	64454686

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R06AA11	RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Aminoalkyl ethers
CHEBI has role	CHEBI:37955	H1 receptor antagonists
CHEBI has role	CHEBI:50919	antiemetico
MeSH PA	D000932	Antiemetics
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D005765	Gastrointestinal Agents
MeSH PA	D018494	Histamine Agents
MeSH PA	D006633	Histamine Antagonists
MeSH PA	D006634	Histamine H1 Antagonists
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018373	Peripheral Nervous System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Nausea and vomiting	indication	16932000
Motion sickness	indication	37031009	DOID:2951
Vertigo	indication	399153001
Vomiting	indication	422400008
Nausea	indication	422587007
Prevention of Motion Sickness	indication
Prevention of Nausea and Vomiting	indication
Ménière's disease	off-label use	13445001	DOID:9849
Ocular hypertension	contraindication	4210003	DOID:9282
Hypophosphatemia	contraindication	4996001
Alcoholism	contraindication	7200002
Peptic ulcer	contraindication	13200003	DOID:750
Myocardial infarction	contraindication	22298006	DOID:5844
Hyperthyroidism	contraindication	34486009	DOID:7998
Hypertensive disorder	contraindication	38341003	DOID:10763
Low blood pressure	contraindication	45007003
Blood coagulation disorder	contraindication	64779008	DOID:1247
Diabetes mellitus	contraindication	73211009	DOID:9351
Hyperglycemia	contraindication	80394007	DOID:4195
Chronic idiopathic constipation	contraindication	82934008
Gout	contraindication	90560007	DOID:13189
Liver function tests abnormal	contraindication	166603001
Arterial hemorrhage	contraindication	234003006
Disease of liver	contraindication	235856003	DOID:409
Bladder outflow obstruction	contraindication	236645006
Pyloric obstruction	contraindication	244815007
Benign prostatic hyperplasia	contraindication	266569009
Retention of urine	contraindication	267064002
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Acute coronary syndrome	contraindication	394659003
Disorder of coronary artery	contraindication	414024009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN	ANTAGONIST	Ki	7.43	DRUG MATRIX	CHEMBL
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		Ki	6.31	DRUG MATRIX
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	5.70	DRUG MATRIX
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	6.70	DRUG MATRIX
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	5.96	DRUG MATRIX
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	6.48	DRUG MATRIX
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	5.60	DRUG MATRIX
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN		Ki	6.96	DRUG MATRIX
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN		Ki	6.79	DRUG MATRIX
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN		Ki	7.02	DRUG MATRIX
Muscarinic acetylcholine receptor M4	GPCR	P08173	ACM4_HUMAN		Ki	7.10	DRUG MATRIX
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN		Ki	6.64	DRUG MATRIX
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Ki	5.75	DRUG MATRIX
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		IC50	5.82	DRUG MATRIX
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	5.79	DRUG MATRIX
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN		Ki	5.85	DRUG MATRIX

External reference:

ID	Source
4018048	VUID
N0000146389	NUI
D00520	KEGG_DRUG
151666	RXNORM
4018048	VANDF
C0012381	UMLSCUI
CHEBI:4604	CHEBI
CHEMBL1200406	ChEMBL_ID
DB00985	DRUGBANK_ID
D004111	MESH_DESCRIPTOR_UI
10660	PUBCHEM_CID
61	INN_ID
JB937PER5C	UNII
1568	MMSL
4605	MMSL
6646	MMSL
d00861	MMSL
003371	NDDF
387469006	SNOMEDCT_US
81073007	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Wal-Dram	HUMAN OTC DRUG LABEL	1	0363-0198	TABLET	50 mg	ORAL	OTC MONOGRAPH FINAL	15 sections
Wal-Dram	HUMAN OTC DRUG LABEL	1	0363-0198	TABLET	50 mg	ORAL	OTC MONOGRAPH FINAL	15 sections
Wal-Dram	HUMAN OTC DRUG LABEL	1	0363-0198	TABLET	50 mg	ORAL	OTC MONOGRAPH FINAL	15 sections
Wal-Dram	HUMAN OTC DRUG LABEL	1	0363-0198	TABLET	50 mg	ORAL	OTC MONOGRAPH FINAL	15 sections
Motion Sickness Relief	HUMAN OTC DRUG LABEL	1	0363-1980	TABLET	50 mg	ORAL	OTC monograph final	15 sections
Motion Sickness Relief	HUMAN OTC DRUG LABEL	1	0363-1980	TABLET	50 mg	ORAL	OTC monograph final	15 sections
Driminate	HUMAN OTC DRUG LABEL	1	0904-2051	TABLET	50 mg	ORAL	OTC monograph final	15 sections
Driminate	HUMAN OTC DRUG LABEL	1	0904-2051	TABLET	50 mg	ORAL	OTC monograph final	15 sections
Driminate	HUMAN OTC DRUG LABEL	1	0904-2051	TABLET	50 mg	ORAL	OTC monograph final	15 sections
Driminate	HUMAN OTC DRUG LABEL	1	0904-2051	TABLET	50 mg	ORAL	OTC monograph final	15 sections
Dimenhydrinate	HUMAN OTC DRUG LABEL	1	0904-6772	TABLET	50 mg	ORAL	OTC monograph final	16 sections
PhysiciansCare DimenhydrinateMotion Sickness Relief	HUMAN OTC DRUG LABEL	1	0924-1006	TABLET, COATED	50 mg	ORAL	OTC monograph final	16 sections
Dimenhydrinate	HUMAN OTC DRUG LABEL	1	0924-1007	TABLET	50 mg	ORAL	OTC monograph final	17 sections
Gravol	HUMAN OTC DRUG LABEL	1	10237-940	CAPSULE, LIQUID FILLED	50 mg	ORAL	OTC monograph final	15 sections
Gravol	HUMAN OTC DRUG LABEL	1	10237-941	TABLET, COATED	50 mg	ORAL	OTC monograph final	15 sections
Gravol	HUMAN OTC DRUG LABEL	1	10237-942	SYRUP	15 mg	ORAL	OTC monograph final	15 sections
Motion Sickness	HUMAN OTC DRUG LABEL	1	11673-198	TABLET	50 mg	ORAL	OTC MONOGRAPH FINAL	15 sections
Motion Sickness	HUMAN OTC DRUG LABEL	1	11673-198	TABLET	50 mg	ORAL	OTC MONOGRAPH FINAL	15 sections
Motion Sickness	HUMAN OTC DRUG LABEL	1	11673-198	TABLET	50 mg	ORAL	OTC MONOGRAPH FINAL	15 sections
Motion Sickness	HUMAN OTC DRUG LABEL	1	11673-198	TABLET	50 mg	ORAL	OTC MONOGRAPH FINAL	15 sections
Motion Sickness Relief	HUMAN OTC DRUG LABEL	1	11822-0198	TABLET	50 mg	ORAL	OTC monograph final	15 sections
Motion Sickness Relief	HUMAN OTC DRUG LABEL	1	11822-0198	TABLET	50 mg	ORAL	OTC monograph final	15 sections
Dramamine	HUMAN OTC DRUG LABEL	1	29485-1216	TABLET, CHEWABLE	50 mg	ORAL	OTC monograph final	16 sections
Dramamine	HUMAN OTC DRUG LABEL	1	29485-6925	TABLET, CHEWABLE	50 mg	ORAL	OTC monograph final	16 sections
Dramamine	HUMAN OTC DRUG LABEL	1	29485-8048	TABLET, CHEWABLE	50 mg	ORAL	OTC monograph final	16 sections
Motion Sickness Relief	HUMAN OTC DRUG LABEL	1	36800-930	TABLET	50 mg	ORAL	OTC monograph final	15 sections
Motion Sickness Relief	HUMAN OTC DRUG LABEL	1	36800-930	TABLET	50 mg	ORAL	OTC monograph final	15 sections
Motion Sickness Relief	HUMAN OTC DRUG LABEL	1	46122-536	TABLET	50 mg	ORAL	OTC monograph final	15 sections
Motion Sickness Relief	HUMAN OTC DRUG LABEL	1	46122-536	TABLET	50 mg	ORAL	OTC monograph final	15 sections
Motion Sickness Relief	HUMAN OTC DRUG LABEL	1	46122-536	TABLET	50 mg	ORAL	OTC monograph final	15 sections