diltiazem 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, diltiazem derivatives 897 42399-41-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • (+)-Diltiazem
  • dilzem
  • d-Diltiazem
  • d-cis-Diltiazem
  • diltiazem hydrochloride
  • diltiazem malate
  • diltiazem
  • diltiazem HCl
A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
  • Molecular weight: 414.52
  • Formula: C22H26N2O4S
  • CLOGP: 3.65
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 59.08
  • ALOGS: -4.39
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.24 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 19.30 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 40 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 13 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.18 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.60 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.043 High 0.81
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.859 High 0.81
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 35.237 10^-6 cm/s High 0.81
dh-clint Dog hepatocyte intrinsic clearance 22.909 uL/min/10^6 cells High 0.81
dppb Dog plasma protein binding (% unbound) 33.900 % High 0.81
fcs-ppb Fetal calf serum protein binding (% unbound) 40.780 % High 0.81
herg hERG pIC50 5.072 pIC50 High 0.81
hh-clint Human hepatocyte intrinsic clearance 11.220 uL/min/10^6 cells High 0.81
hlm-clint Human liver microsomal intrinsic clearance 58.210 uL/min/mg protein High 0.81
hppb Human plasma protein binding (% unbound) 33.080 % High 0.81
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK1,JAK2,JAK3,KIT,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ZAP70 55
kinase-selectivity-class AXL,BRAF,ERBB2,GRK2,PDK4,STK33 6
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.225 High 0.81
mh-clint Mouse hepatocyte intrinsic clearance 198.153 High 0.81
mppb Mouse plasma protein binding (% unbound) 29.470 High 0.81
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 5.848 High 0.81
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
pppb Pig plasma protein binding (% unbound) 57.260 % High 0.81
rh-clint Rat hepatocyte intrinsic clearance 317.687 uL/min/10^6 cells High 0.81
rh-fuinc Rat hepatocyte fraction unbound in incubation 78.090 % High 0.81
rppb Rat plasma protein binding (% unbound) 29.950 % High 0.81
solubility-dd Solubility at pH 7.4 in DMSO 855.067 uM High 0.81

Approvals:

DateAgencyCompanyOrphan
Nov. 5, 1982 FDA VALEANT INTL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 696.01 9.86 1072 163909 143986 90319480
Sedation complication 607.98 9.86 381 164600 16563 90446903
Creatinine renal clearance decreased 603.88 9.86 395 164586 18504 90444962
Atrial fibrillation 549.90 9.86 921 164060 132690 90330776
Orthostatic hypotension 513.92 9.86 498 164483 41329 90422137
Blood calcium decreased 431.59 9.86 391 164590 29791 90433675
Sedation 361.00 9.86 442 164539 47729 90415737
Hypotension 353.69 9.86 1347 163634 324050 90139416
Balance disorder 351.99 9.86 633 164348 96447 90367019
Drug ineffective 300.95 9.86 1400 163581 1382898 89080568
Cognitive disorder 291.42 9.86 483 164498 68924 90394542
Depressed level of consciousness 260.49 9.86 472 164509 72312 90391154
Off label use 253.35 9.86 1091 163890 1101161 89362305
Toxicity to various agents 245.98 9.86 1107 163874 286739 90176727
Cardiac failure congestive 243.20 9.86 548 164433 98146 90365320
Bradycardia 219.48 9.86 477 164504 83370 90380096
Maternal exposure during pregnancy 178.92 9.86 236 164745 359827 90103639
Suspected suicide 177.64 9.86 144 164837 9424 90454042
Neutropenia 171.60 9.86 98 164883 224806 90238660
Nerve injury 143.49 9.86 136 164845 10970 90452496
Dyspnoea 137.49 9.86 2308 162673 878647 89584819
Fall 128.84 9.86 1392 163589 480418 89983048
Urinary tract discomfort 128.77 9.86 52 164929 860 90462606
Febrile neutropenia 123.64 9.86 67 164914 158282 90305184
Alveolar osteitis 119.19 9.86 53 164928 1124 90462342
Pulmonary congestion 113.88 9.86 158 164823 19275 90444191
Nephrolithiasis 112.53 9.86 265 164716 48820 90414646
Systemic lupus erythematosus rash 112.45 9.86 64 164917 2325 90461141
Exposure during pregnancy 111.60 9.86 163 164818 238247 90225219
Atrioventricular block complete 111.51 9.86 112 164869 9699 90453767
Anti-cyclic citrullinated peptide antibody 109.63 9.86 186 164795 27035 90436431
Tunnel vision 100.63 9.86 53 164928 1648 90461818
Dyspnoea exertional 96.05 9.86 320 164661 71968 90391498
Bladder pain 94.30 9.86 60 164921 2677 90460789
Animal scratch 94.23 9.86 52 164929 1778 90461688
Treatment failure 92.72 9.86 266 164715 303662 90159804
Product use issue 92.63 9.86 300 164681 329619 90133847
Oedema peripheral 89.85 9.86 788 164193 257127 90206339
Heart rate increased 87.27 9.86 422 164559 112480 90350986
Rales 85.82 9.86 124 164857 15703 90447763
Malignant neoplasm progression 85.21 9.86 44 164937 106826 90356640
BRASH syndrome 84.87 9.86 49 164932 1830 90461636
Chest pain 83.23 9.86 919 164062 318726 90144740
Foot deformity 82.78 9.86 268 164713 59383 90404083
Drug intolerance 81.68 9.86 479 164502 447112 90016354
Constipation 77.55 9.86 816 164165 279579 90183887
Therapeutic product effect incomplete 76.46 9.86 148 164833 193748 90269718
Paranasal sinus discomfort 76.35 9.86 74 164907 6136 90457330
Myelosuppression 74.85 9.86 6 164975 53585 90409881
Ear congestion 72.93 9.86 56 164925 3386 90460080
Body tinea 71.31 9.86 46 164935 2102 90461364
Labile blood pressure 71.16 9.86 44 164937 1866 90461600
Wound complication 70.62 9.86 63 164918 4700 90458766
Inhibitory drug interaction 70.41 9.86 53 164928 3110 90460356
Asthma 70.40 9.86 712 164269 241448 90222018
Bronchitis 70.16 9.86 498 164483 152429 90311037
Gastrointestinal procedural complication 69.84 9.86 28 164953 454 90463012
Creatinine renal clearance increased 68.68 9.86 53 164928 3228 90460238
Polymyalgia rheumatica 68.24 9.86 63 164918 4914 90458552
Abortion spontaneous 67.90 9.86 9 164972 54047 90409419
Disease progression 67.62 9.86 113 164868 156502 90306964
Atrioventricular block second degree 66.24 9.86 59 164922 4393 90459073
Rash 66.00 9.86 1036 163945 795064 89668402
White blood cell count decreased 63.78 9.86 130 164851 166979 90296487
Myopathy 63.44 9.86 99 164882 13419 90450047
Bunion operation 62.90 9.86 36 164945 1322 90462144
Pericardial haemorrhage 61.85 9.86 40 164941 1836 90461630
Pancytopenia 61.53 9.86 77 164904 120186 90343280
Medication error 60.85 9.86 310 164671 84342 90379124
Bronchopulmonary aspergillosis allergic 60.22 9.86 52 164929 3714 90459752
Blood iron decreased 58.62 9.86 112 164869 17847 90445619
Pulmonary arterial hypertension 58.52 9.86 140 164841 26047 90437419
Weight decreased 56.27 9.86 988 163993 378922 90084544
Wound secretion 54.95 9.86 56 164925 4934 90458532
Sinus pain 54.88 9.86 58 164923 5331 90458135
Leukopenia 54.16 9.86 62 164919 100648 90362818
Blood pressure systolic increased 53.97 9.86 230 164751 58115 90405351
Renal function test abnormal 53.87 9.86 66 164915 7125 90456341
Gastrointestinal haemorrhage 53.76 9.86 314 164667 89934 90373532
Injection site erythema 53.67 9.86 60 164921 98442 90365024
Atrial flutter 53.59 9.86 81 164900 10677 90452789
Limb injury 53.52 9.86 152 164829 31356 90432110
Therapeutic product effect decreased 52.76 9.86 293 164688 277278 90186188
Cardiogenic shock 52.74 9.86 129 164852 24339 90439127
Heart rate decreased 51.11 9.86 213 164768 53292 90410174
Lupus vulgaris 50.82 9.86 189 164792 44870 90418596
Infection susceptibility increased 50.57 9.86 48 164933 3878 90459588
Contusion 50.47 9.86 688 164293 250528 90212938
Drug interaction 50.29 9.86 744 164237 275709 90187757
Coeliac disease 50.28 9.86 10 164971 44600 90418866
Chronic obstructive pulmonary disease 50.05 9.86 266 164715 73563 90389903
Lower limb fracture 49.48 9.86 294 164687 84719 90378747
Neutrophil count decreased 49.26 9.86 35 164946 71497 90391969
Alveolitis 48.89 9.86 42 164939 2979 90460487
Joint dislocation 48.62 9.86 185 164796 44397 90419069
Mesenteric haematoma 48.41 9.86 13 164968 51 90463415
Epilepsy 48.25 9.86 47 164934 82159 90381307
Fluid retention 47.70 9.86 299 164682 87792 90375674
Mucosal inflammation 47.02 9.86 23 164958 57602 90405864
Heart sounds 46.85 9.86 28 164953 1116 90462350
Mobility decreased 46.47 9.86 677 164304 250057 90213409
Nodal rhythm 46.20 9.86 33 164948 1785 90461681
Foetal exposure during pregnancy 45.67 9.86 11 164970 42964 90420502
Hunger 45.59 9.86 58 164923 6505 90456961
Oedema 45.45 9.86 561 164420 199734 90263732
Retinitis 44.79 9.86 163 164818 38295 90425171
Prolonged expiration 44.41 9.86 28 164953 1229 90462237
Prescribed underdose 44.02 9.86 260 164721 74759 90388707
Cellulitis 42.20 9.86 298 164683 91039 90372427
Atrioventricular block 41.98 9.86 65 164916 8750 90454716
Walking aid user 41.78 9.86 151 164830 35355 90428111
Vomiting 41.58 9.86 1105 163876 787188 89676278
Ischaemic contracture of the left ventricle 41.58 9.86 14 164967 134 90463332
Respiratory tract congestion 41.56 9.86 127 164854 27283 90436183
Feeling cold 41.41 9.86 127 164854 27338 90436128
Suicidal ideation 41.32 9.86 44 164937 73811 90389655
Onychomadesis 41.27 9.86 16 164965 45982 90417484
Laryngitis 40.86 9.86 192 164789 50561 90412905
Cardiac disorder 40.68 9.86 208 164773 56664 90406802
Bone erosion 40.10 9.86 197 164784 52824 90410642
Porphyria acute 40.06 9.86 96 164885 17879 90445587
Hepatic ischaemia 39.58 9.86 22 164959 763 90462703
Alanine aminotransferase increased 39.49 9.86 99 164882 118239 90345227
Erythema 39.31 9.86 250 164731 228996 90234470
Intentional self-injury 39.04 9.86 4 164977 29330 90434136
Pain in jaw 38.98 9.86 182 164799 47803 90415663
Skin laceration 38.89 9.86 120 164861 25915 90437551
Coronary artery disease 38.73 9.86 142 164839 33481 90429985
Obstructive airways disorder 38.42 9.86 119 164862 25750 90437716
Finger deformity 37.87 9.86 7 164974 32890 90430576
Injury 37.80 9.86 536 164445 196813 90266653
Nausea 37.44 9.86 1647 163334 1108669 89354797
Seronegative arthritis 37.05 9.86 94 164887 18140 90445326
Aspartate aminotransferase increased 36.83 9.86 83 164898 102854 90360612
Dislocation of vertebra 36.81 9.86 200 164781 55768 90407698
Adjustment disorder with depressed mood 36.78 9.86 202 164779 56551 90406915
Impaired healing 36.41 9.86 614 164367 233585 90229881
Pneumonia 36.40 9.86 1463 163518 636596 89826870
Poor quality sleep 36.13 9.86 113 164868 24580 90438886
Full blood count abnormal 35.98 9.86 147 164834 36450 90427016
Product use in unapproved indication 35.55 9.86 416 164565 335820 90127646
Multiple drug therapy 35.24 9.86 53 164928 6956 90456510
Forced expiratory volume decreased 35.20 9.86 48 164933 5760 90457706
Alopecia 34.87 9.86 663 164318 494408 89969058
Blepharospasm 34.55 9.86 30 164951 55415 90408051
Lupus-like syndrome 34.49 9.86 178 164803 48668 90414798
Tooth infection 33.96 9.86 97 164884 20073 90443393
Sleep disorder due to general medical condition, insomnia type 33.88 9.86 371 164610 128323 90335143
Myocardial hypoxia 33.73 9.86 8 164973 16 90463450
Pulmonary hypertension 33.60 9.86 160 164821 42363 90421103
Peripheral swelling 33.29 9.86 986 163995 412120 90051346
Hepatic cirrhosis 33.19 9.86 213 164768 63040 90400426
Hypokinesia 33.03 9.86 82 164899 15615 90447851
Red blood cell sedimentation rate abnormal 33.01 9.86 3 164978 24201 90439265
Blood urine present 32.98 9.86 87 164894 17191 90446275
Cardiac ablation 32.38 9.86 26 164955 1678 90461788
Angina pectoris 32.15 9.86 149 164832 39011 90424455
Hepatotoxicity 32.13 9.86 22 164959 45820 90417646
Muscle relaxant therapy 32.00 9.86 12 164969 161 90463305
Death 31.88 9.86 1071 163910 455480 90007986
Arthropathy 31.81 9.86 472 164509 365770 90097696
Deep vein thrombosis postoperative 31.53 9.86 229 164752 70580 90392886
Hepatitis 31.49 9.86 50 164931 70689 90392777
Joint swelling 31.29 9.86 688 164293 502612 89960854
Kidney infection 31.16 9.86 111 164870 25805 90437661
Sleep disorder 31.07 9.86 520 164461 197510 90265956
Arthralgia 30.42 9.86 1135 163846 777387 89686079
Cardiac arrest 30.20 9.86 308 164673 104627 90358839
Glucose tolerance impaired 30.11 9.86 53 164928 7932 90455534
Drug resistance 30.08 9.86 9 164972 30440 90433026
Agranulocytosis 30.06 9.86 13 164968 34989 90428477
Pain in extremity 29.97 9.86 1051 163930 449478 90013988
Taste disorder 29.84 9.86 41 164940 61505 90401961
Ear infection 29.56 9.86 223 164758 69552 90393914
Torsade de pointes 29.54 9.86 77 164904 15105 90448361
Device pacing issue 29.40 9.86 10 164971 99 90463367
Myocardial infarction 29.05 9.86 308 164673 105664 90357802
Bladder prolapse 29.01 9.86 27 164954 2128 90461338
Nail disorder 28.99 9.86 39 164942 59028 90404438
Atrioventricular block first degree 28.92 9.86 54 164927 8457 90455009
Pollakiuria 28.90 9.86 128 164853 32877 90430589
Systemic lupus erythematosus 28.86 9.86 474 164507 361422 90102044
Thrombocytopenia 28.85 9.86 242 164739 208483 90254983
Calculus urinary 28.28 9.86 24 164957 1674 90461792
Infusion related reaction 27.86 9.86 563 164418 416217 90047249
Allergy to venom 27.72 9.86 6 164975 6 90463460
Pulmonary embolism 27.70 9.86 133 164848 130687 90332779
Premature baby 27.48 9.86 6 164975 25071 90438395
Onychomycosis 27.47 9.86 17 164964 37359 90426107
Exostosis 27.31 9.86 178 164803 52956 90410510
Pemphigus 26.76 9.86 426 164555 326438 90137028
Transfusion 26.49 9.86 81 164900 17407 90446059
Anaphylactic reaction 26.36 9.86 77 164904 87447 90376019
Platelet count decreased 26.32 9.86 144 164837 136825 90326641
Hepatorenal syndrome 26.30 9.86 25 164956 2023 90461443
Arteriovenous fistula occlusion 26.12 9.86 13 164968 358 90463108
Bone marrow failure 26.07 9.86 13 164968 32208 90431258
Cytomegalovirus infection 26.03 9.86 8 164973 26594 90436872
Erythrodermic psoriasis 25.66 9.86 19 164962 1087 90462379
Abdominal discomfort 25.65 9.86 667 164314 476661 89986805
Palpitations 25.63 9.86 370 164611 136358 90327108
Nephroangiosclerosis 25.61 9.86 11 164970 214 90463252
Hypoxia 25.58 9.86 222 164759 72177 90391289
Hyperkalaemia 25.51 9.86 204 164777 64760 90398706
Bronchiectasis 25.46 9.86 94 164887 22236 90441230
Paraesthesia oral 25.28 9.86 13 164968 31646 90431820
Renal failure 25.15 9.86 356 164625 130651 90332815
Sebaceous gland infection 25.07 9.86 10 164971 160 90463306
Injection site pruritus 24.97 9.86 37 164944 53797 90409669
COVID-19 24.59 9.86 193 164788 168650 90294816
Cardiac pacemaker insertion 24.58 9.86 35 164946 4372 90459094
Hypoacusis 24.38 9.86 108 164873 27742 90435724
Metastases to liver 24.27 9.86 11 164970 28796 90434670
No adverse event 24.17 9.86 55 164926 67927 90395539
Injection site swelling 24.16 9.86 45 164936 59794 90403672
Nasal polyps 24.13 9.86 58 164923 10822 90452644
Productive cough 24.02 9.86 230 164751 76833 90386633
Hyperglycaemia 23.95 9.86 167 164814 50803 90412663
Oxygen saturation decreased 23.91 9.86 300 164681 107183 90356283
Arteriospasm coronary 23.72 9.86 37 164944 5013 90458453
Cardiac failure 23.67 9.86 304 164677 109192 90354274
Unevaluable event 23.63 9.86 176 164805 54672 90408794
Spinal fusion surgery 23.60 9.86 62 164919 12221 90451245
Hypervolaemia 23.56 9.86 120 164861 32637 90430829
Disturbance in attention 23.22 9.86 31 164950 47078 90416388
Blood bilirubin increased 23.11 9.86 27 164954 43443 90420023
Amnesia 22.93 9.86 300 164681 108205 90355261
Premature delivery 22.93 9.86 22 164959 38740 90424726
Blue toe syndrome 22.82 9.86 13 164968 473 90462993
Movement disorder 22.79 9.86 109 164872 28910 90434556
Respiration abnormal 22.78 9.86 47 164934 7916 90455550
Nodule 22.78 9.86 10 164971 26676 90436790
Contraindicated product administered 22.74 9.86 428 164553 319711 90143755
Metastases to bone 22.67 9.86 9 164972 25496 90437970
Back injury 22.66 9.86 31 164950 46591 90416875
X-ray abnormal 22.63 9.86 151 164830 45273 90418193
Cough 22.63 9.86 853 164128 368109 90095357
Incision site haemorrhage 22.42 9.86 14 164967 604 90462862
Rectal prolapse 22.38 9.86 24 164957 2243 90461223
Multiple sclerosis relapse 22.32 9.86 38 164943 52267 90411199
Muscle injury 22.16 9.86 448 164533 176206 90287260
Synovitis 22.16 9.86 445 164536 329307 90134159
Abdominal pain 22.04 9.86 550 164431 395171 90068295
Bezoar 21.96 9.86 26 164955 2708 90460758
Macular degeneration 21.94 9.86 22 164959 37948 90425518
Chronic sinusitis 21.82 9.86 8 164973 23794 90439672
Spondylitis 21.78 9.86 66 164915 14112 90449354
Status epilepticus 21.76 9.86 4 164977 18870 90444596
Joint injury 21.66 9.86 117 164864 32547 90430919
Cytokine release syndrome 21.58 9.86 12 164969 27961 90435505
Wound infection 21.58 9.86 292 164689 106110 90357356
Drug hypersensitivity 21.55 9.86 661 164320 462948 90000518
Autoimmune disorder 21.48 9.86 224 164757 76520 90386946
Stent placement 21.44 9.86 32 164949 4171 90459295
Supraventricular tachycardia 21.41 9.86 72 164909 16264 90447202
Pulseless electrical activity 21.32 9.86 49 164932 8883 90454583
Fatigue 21.23 9.86 1811 163170 1152212 89311254
Pulmonary oedema 21.22 9.86 189 164792 61891 90401575
Seizure 21.07 9.86 177 164804 152452 90311014
International normalised ratio increased 21.05 9.86 153 164828 47163 90416303
Product residue present 20.94 9.86 32 164949 4259 90459207
Osteoporosis 20.86 9.86 268 164713 96263 90367203
Occult blood 20.76 9.86 18 164963 1293 90462173
Syncope 20.67 9.86 348 164633 132315 90331151
Gouty tophus 20.66 9.86 10 164971 259 90463207
Anal abscess 20.38 9.86 37 164944 5671 90457795
Delirium 20.19 9.86 284 164697 104075 90359391
Female genital tract fistula 20.15 9.86 4 164977 17864 90445602
Road traffic accident 20.07 9.86 291 164690 107335 90356131
Fibrous histiocytoma 19.90 9.86 13 164968 607 90462859
Hypoaesthesia oral 19.78 9.86 68 164913 15532 90447934
Vasoplegia syndrome 19.75 9.86 25 164956 2789 90460677
Heart rate irregular 19.67 9.86 92 164889 24176 90439290
Metastases to central nervous system 19.63 9.86 4 164977 17538 90445928
Thermal burn 19.45 9.86 40 164941 6722 90456744
Hyperlipidaemia 19.41 9.86 88 164893 22828 90440638
Septic shock 19.35 9.86 83 164898 84077 90379389
Psychotic disorder 19.33 9.86 17 164964 31213 90432253
Inflammation 19.23 9.86 220 164761 178372 90285094
Hypovolaemia 19.22 9.86 58 164923 12373 90451093
Psoriatic arthropathy 19.21 9.86 296 164685 228039 90235427
Nodal arrhythmia 18.85 9.86 17 164964 1286 90462180
Skin exfoliation 18.85 9.86 62 164919 67851 90395615
Dizziness 18.80 9.86 1279 163702 588005 89875461
Neutropenic sepsis 18.57 9.86 5 164976 18125 90445341
Hepatic function abnormal 18.52 9.86 35 164946 46253 90417213
Colon gangrene 18.48 9.86 4 164977 4 90463462
Erythromelalgia 18.42 9.86 10 164971 331 90463135
Generalised tonic-clonic seizure 18.21 9.86 22 164959 34881 90428585
Peak expiratory flow rate abnormal 18.14 9.86 7 164974 102 90463364
Haematuria 17.93 9.86 117 164864 34820 90428646
Interstitial lung disease 17.78 9.86 75 164906 76330 90387136
Antidepressant drug level above therapeutic 17.53 9.86 11 164970 479 90462987
Impaired quality of life 17.50 9.86 86 164895 23058 90440408
Bladder disorder 17.36 9.86 51 164930 10721 90452745
Rheumatoid arthritis 17.33 9.86 515 164466 362099 90101367
Arrhythmogenic right ventricular dysplasia 17.32 9.86 5 164976 27 90463439
Hypothyroidism 17.29 9.86 45 164936 53082 90410384
Mental disorder 17.26 9.86 20 164961 32298 90431168
Blood pressure inadequately controlled 16.95 9.86 36 164945 6188 90457278
Suicide attempt 16.94 9.86 75 164906 75324 90388142
Polyneuropathy 16.90 9.86 7 164974 19334 90444132
Thrombotic microangiopathy 16.78 9.86 4 164977 15739 90447727
Skin necrosis 16.75 9.86 5 164976 16936 90446530
Coronary artery bypass 16.70 9.86 21 164960 2328 90461138
Hepatic cytolysis 16.65 9.86 19 164962 30897 90432569
Product quality issue 16.59 9.86 81 164900 79244 90384222
Humidity intolerance 16.48 9.86 10 164971 410 90463056
Palmar-plantar erythrodysaesthesia syndrome 16.47 9.86 16 164965 28007 90435459
Cardioactive drug level increased 16.45 9.86 21 164960 2363 90461103
Sinoatrial block 16.32 9.86 14 164967 991 90462475
Respiratory rate increased 16.31 9.86 65 164916 15936 90447530
Cardioversion 16.23 9.86 16 164965 1354 90462112
Proctitis 16.03 9.86 4 164977 15255 90448211
Disability 16.02 9.86 128 164853 40617 90422849
Coagulopathy 15.84 9.86 84 164897 23205 90440261
Neuropathy peripheral 15.83 9.86 166 164815 136804 90326662
Gamma-glutamyltransferase increased 15.80 9.86 28 164953 37924 90425542
Gravitational oedema 15.78 9.86 15 164966 1214 90462252
Thyrotoxic crisis 15.76 9.86 15 164966 1216 90462250
Nasopharyngitis 15.62 9.86 898 164083 406206 90057260
Dysphagia 15.58 9.86 130 164851 112148 90351318
Heavy menstrual bleeding 15.56 9.86 9 164972 20521 90442945
Hospitalisation 15.45 9.86 323 164658 127777 90335689
Basal cell carcinoma 15.44 9.86 23 164958 33366 90430100
Ventricular arrhythmia 15.42 9.86 28 164953 4293 90459173
Hepatic enzyme increased 15.39 9.86 520 164461 360216 90103250
Carbon dioxide increased 15.34 9.86 18 164963 1857 90461609
Insomnia 15.28 9.86 748 164233 332726 90130740
Adverse reaction 15.21 9.86 19 164962 29693 90433773
Electrocardiogram U wave present 15.10 9.86 6 164975 95 90463371
Affect lability 15.06 9.86 7 164974 18056 90445410
Acute lung injury 15.04 9.86 16 164965 1482 90461984
Parotid gland enlargement 15.04 9.86 13 164968 930 90462536
Purpura 15.03 9.86 60 164921 14718 90448748
Neoplasm progression 15.01 9.86 37 164944 44449 90419017
Injection site urticaria 14.98 9.86 7 164974 18004 90445462
Anion gap abnormal 14.87 9.86 9 164972 367 90463099
Drug reaction with eosinophilia and systemic symptoms 14.87 9.86 35 164946 42723 90420743
Tachycardia 14.82 9.86 384 164597 157289 90306177
Presyncope 14.82 9.86 104 164877 31701 90431765
Lymphopenia 14.72 9.86 12 164969 22869 90440597
Angina unstable 14.70 9.86 37 164944 7106 90456360
Catheter site haemorrhage 14.68 9.86 25 164956 3643 90459823
Distributive shock 14.59 9.86 24 164957 3400 90460066
Drug ineffective for unapproved indication 14.55 9.86 67 164914 66577 90396889
Irritable bowel syndrome 14.53 9.86 487 164494 206961 90256505
Inappropriate schedule of product administration 14.50 9.86 189 164792 149744 90313722
Ventricular extrasystoles 14.46 9.86 55 164926 13195 90450271
Cardiac monitoring 14.46 9.86 4 164977 18 90463448
Wrong technique in product usage process 14.44 9.86 74 164907 71497 90391969
Condition aggravated 14.37 9.86 913 164068 594632 89868834
Caesarean section 14.29 9.86 8 164973 18569 90444897
Sinus bradycardia 14.28 9.86 65 164916 16887 90446579
Lower gastrointestinal haemorrhage 14.23 9.86 42 164939 8850 90454616
Oxygen consumption increased 14.22 9.86 28 164953 4561 90458905
Electrocardiogram QT shortened 14.16 9.86 7 164974 190 90463276
Transaminases increased 14.12 9.86 29 164952 37163 90426303
Vaginal discharge 14.10 9.86 9 164972 19455 90444011
Cerebrovascular accident 14.09 9.86 309 164672 123224 90340242
Unresponsive to stimuli 14.04 9.86 118 164863 38003 90425463
Wrist fracture 13.99 9.86 61 164920 15563 90447903
Musculoskeletal stiffness 13.95 9.86 422 164559 296110 90167356
Intentional product use issue 13.87 9.86 295 164686 216597 90246869
Bone disorder 13.82 9.86 13 164968 23107 90440359
Anaemia 13.80 9.86 514 164467 352288 90111178
Depressive symptom 13.74 9.86 30 164951 5255 90458211
Human ehrlichiosis 13.74 9.86 7 164974 203 90463263
Upper respiratory tract infection 13.71 9.86 318 164663 128000 90335466
Cerebellar syndrome 13.70 9.86 25 164956 3847 90459619
Accidental exposure to product 13.70 9.86 36 164945 42330 90421136
Migraine 13.67 9.86 254 164727 190138 90273328
Metastases to lung 13.64 9.86 6 164975 15985 90447481
Hypercalcaemia 13.60 9.86 26 164955 34214 90429252
Tooth disorder 13.52 9.86 100 164881 30990 90432476
Product label confusion 13.48 9.86 13 164968 22837 90440629
Oral papilloma 13.48 9.86 5 164976 65 90463401
C-reactive protein increased 13.33 9.86 241 164740 181148 90282318
Peritonitis 13.10 9.86 10 164971 19695 90443771
Acute myeloid leukaemia 13.06 9.86 11 164970 20629 90442837
Leukaemoid reaction 13.05 9.86 7 164974 226 90463240
Immunodeficiency 13.04 9.86 38 164943 43196 90420270
Hypercholesterolaemia 13.02 9.86 257 164724 100635 90362831
Injection site pain 13.02 9.86 230 164751 173469 90289997
Stupor 13.00 9.86 30 164951 5452 90458014
Atrioventricular dissociation 12.99 9.86 7 164974 228 90463238
Catheter site erythema 12.97 9.86 28 164953 4866 90458600
Device difficult to use 12.84 9.86 8 164973 17517 90445949
Hemiparesis 12.78 9.86 24 164957 31795 90431671
Cytopenia 12.74 9.86 8 164973 17441 90446025
Catheterisation cardiac 12.73 9.86 28 164953 4928 90458538
Abortion induced 12.71 9.86 3 164978 11885 90451581
Acute generalised exanthematous pustulosis 12.65 9.86 54 164927 13649 90449817
Aphasia 12.65 9.86 38 164943 42774 90420692
Visual impairment 12.63 9.86 323 164658 132042 90331424
Pulmonary fibrosis 12.61 9.86 270 164711 107233 90356233
Irritability 12.55 9.86 29 164952 35633 90427833
Fungal infection 12.50 9.86 38 164943 42623 90420843
Parkinsonism 12.44 9.86 5 164976 14060 90449406
Seasonal allergy 12.43 9.86 78 164903 22905 90440561
Sinus disorder 12.36 9.86 106 164875 34341 90429125
Product complaint 12.31 9.86 53 164928 13447 90450019
Ascites 12.29 9.86 45 164936 47695 90415771
Sensory loss 12.24 9.86 9 164972 18066 90445400
Sinus node dysfunction 12.16 9.86 29 164952 5383 90458083
Abnormal behaviour 12.09 9.86 14 164967 22614 90440852
Blood pressure diastolic decreased 12.08 9.86 87 164894 26739 90436727
Aortic arteriosclerosis 12.02 9.86 36 164945 7648 90455818
Dysuria 11.98 9.86 117 164864 39284 90424182
Oral pain 11.98 9.86 26 164955 32657 90430809
Oral herpes 11.94 9.86 103 164878 33421 90430045
Normal newborn 11.90 9.86 15 164966 23347 90440119
Deep vein thrombosis 11.86 9.86 108 164873 91512 90371954
Blood pressure increased 11.85 9.86 455 164526 196762 90266704
Restlessness 11.82 9.86 30 164951 35690 90427776
Renal pain 11.81 9.86 36 164945 7723 90455743
Catheter site discharge 11.80 9.86 18 164963 2391 90461075
Histamine abnormal 11.79 9.86 3 164978 9 90463457
Posterior reversible encephalopathy syndrome 11.74 9.86 14 164967 22325 90441141
Cardiac valve disease 11.70 9.86 26 164955 4609 90458857
Progressive multifocal leukoencephalopathy 11.67 9.86 7 164974 15648 90447818
Product commingling 11.62 9.86 6 164975 179 90463287
Panic attack 11.58 9.86 85 164896 26280 90437186
Encephalitis 11.54 9.86 3 164978 11131 90452335
Joint stiffness 11.53 9.86 203 164778 77839 90385627
Urinary retention 11.51 9.86 33 164948 37711 90425755
Joint range of motion decreased 11.51 9.86 326 164655 135317 90328149
Bundle branch block left 11.46 9.86 36 164945 7849 90455617
Rectal haemorrhage 11.44 9.86 213 164768 82531 90380935
Premature labour 11.44 9.86 5 164976 13371 90450095
Muscle spasticity 11.43 9.86 30 164951 35292 90428174
Lower respiratory tract infection 11.43 9.86 562 164419 250097 90213369
Fracture 11.43 9.86 14 164967 22062 90441404
Peritoneal haematoma 11.42 9.86 5 164976 102 90463364
Intervertebral disc space narrowing 11.36 9.86 12 164969 1102 90462364
Food allergy 11.35 9.86 18 164963 25460 90438006
Brain oedema 11.33 9.86 9 164972 17376 90446090
Injection site reaction 11.30 9.86 110 164871 91970 90371496
Aplastic anaemia 11.28 9.86 5 164976 13264 90450202
Motor dysfunction 11.27 9.86 11 164970 19219 90444247
Liver injury 11.20 9.86 231 164750 170336 90293130
Aortic stenosis 11.18 9.86 31 164950 6305 90457161
Arrhythmia 11.12 9.86 122 164859 42210 90421256
Sputum purulent 11.10 9.86 13 164968 1339 90462127
Long QT syndrome congenital 11.03 9.86 5 164976 111 90463355
Acne 11.02 9.86 22 164959 28485 90434981
Catheter site inflammation 11.01 9.86 11 164970 946 90462520
Intentional product misuse 11.01 9.86 107 164874 89497 90373969
Hemiplegia 11.00 9.86 8 164973 16152 90447314
Pharyngeal cyst 10.99 9.86 5 164976 112 90463354
Trifascicular block 10.95 9.86 5 164976 113 90463353
Neuroleptic malignant syndrome 10.91 9.86 7 164974 15089 90448377
Aggression 10.81 9.86 20 164961 26648 90436818
Blood pressure systolic 10.78 9.86 4 164977 52 90463414
Grip strength decreased 10.70 9.86 232 164749 92344 90371122
Hypoalbuminaemia 10.65 9.86 8 164973 15889 90447577
Rash erythematous 10.64 9.86 72 164909 65032 90398434
Metastases to lymph nodes 10.59 9.86 4 164977 11685 90451781
Neck pain 10.53 9.86 145 164836 113818 90349648
Central nervous system lesion 10.53 9.86 4 164977 11642 90451824
Body temperature increased 10.46 9.86 126 164855 44584 90418882
Complication of device insertion 10.46 9.86 3 164978 10433 90453033
Hypoventilation 10.45 9.86 27 164954 5269 90458197
Sopor 10.43 9.86 18 164963 24626 90438840
Weight abnormal 10.42 9.86 15 164966 1892 90461574
Drug dependence 10.39 9.86 90 164891 29237 90434229
Total lung capacity decreased 10.39 9.86 22 164959 3773 90459693
Hypochromic anaemia 10.33 9.86 16 164965 2155 90461311
Injection site warmth 10.29 9.86 10 164971 17505 90445961
Malignant melanoma 10.29 9.86 5 164976 12571 90450895
Acute coronary syndrome 10.29 9.86 43 164938 10770 90452696
Tuberculosis 10.25 9.86 5 164976 12544 90450922
Hypothermia 10.23 9.86 8 164973 15567 90447899
Reperfusion arrhythmia 10.18 9.86 6 164975 233 90463233
Electrocardiogram QRS complex prolonged 10.18 9.86 33 164948 7315 90456151
Drug dose omission by device 10.15 9.86 3 164978 10228 90453238
Histoplasmosis 10.15 9.86 16 164965 2188 90461278
Vasculitis 10.14 9.86 16 164965 22677 90440789
Anaphylactic shock 10.12 9.86 27 164954 31590 90431876
Coma 10.12 9.86 84 164897 72548 90390918
Oropharyngeal pain 10.10 9.86 278 164703 114909 90348557
Mouth ulceration 10.08 9.86 38 164943 39936 90423530
Haemophagocytic lymphohistiocytosis 10.08 9.86 8 164973 15451 90448015
Infusion site haemorrhage 10.08 9.86 27 164954 5384 90458082
Breast cancer 10.06 9.86 57 164924 53704 90409762
Appetite disorder 10.04 9.86 38 164943 9095 90454371
Duodenal polyp 10.00 9.86 6 164975 241 90463225
Breast cancer stage II 9.98 9.86 32 164949 35302 90428164
Sepsis 9.97 9.86 250 164731 179564 90283902
Abdominal rigidity 9.90 9.86 17 164964 2495 90460971

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 415.69 10.83 607 62515 95858 42462355
Bradycardia 320.03 10.83 504 62618 84980 42473233
Atrial fibrillation 254.80 10.83 607 62515 138986 42419227
Conjunctivitis allergic 237.75 10.83 133 62989 5778 42552435
Mycotic allergy 224.23 10.83 120 63002 4771 42553442
Spirometry abnormal 221.27 10.83 121 63001 5025 42553188
Mite allergy 220.72 10.83 120 63002 4926 42553287
Dust allergy 214.52 10.83 120 63002 5212 42553001
Normochromic normocytic anaemia 167.84 10.83 125 62997 8906 42549307
Cardiac failure congestive 161.14 10.83 377 62745 85225 42472988
Arteriosclerosis coronary artery 159.28 10.83 166 62956 18511 42539702
Off label use 158.83 10.83 456 62666 637879 41920334
Dyspnoea 140.46 10.83 1126 61996 441495 42116718
Pulmonary vasculitis 135.31 10.83 95 63027 6171 42552042
Hypotension 132.09 10.83 739 62383 256892 42301321
Suspected suicide 131.58 10.83 93 63029 6106 42552107
Nodule 130.14 10.83 124 62998 12410 42545803
Neuritis 128.99 10.83 92 63030 6128 42552085
Arteriosclerosis 117.37 10.83 139 62983 17850 42540363
Eosinophilic granulomatosis with polyangiitis 116.43 10.83 99 63023 8539 42549674
Sleep disorder due to a general medical condition 109.17 10.83 132 62990 17321 42540892
Cardiogenic shock 102.47 10.83 187 62935 35453 42522760
Productive cough 102.35 10.83 232 62890 51335 42506878
Neurological symptom 100.24 10.83 97 63025 9894 42548319
Full blood count abnormal 99.18 10.83 167 62955 29709 42528504
BRASH syndrome 98.61 10.83 50 63072 1775 42556438
Wheezing 94.12 10.83 233 62889 54548 42503665
Hypoxia 90.93 10.83 268 62854 69518 42488695
Respiratory symptom 86.35 10.83 94 63028 11012 42547201
Pulmonary alveolar haemorrhage 84.53 10.83 107 63015 14709 42543504
Asthma 81.84 10.83 240 62882 62074 42496139
Febrile neutropenia 81.45 10.83 93 63029 185610 42372603
Obstructive airways disorder 77.70 10.83 135 62987 24624 42533589
Total lung capacity abnormal 77.02 10.83 59 63063 4384 42553829
Cardiac arrest 72.20 10.83 337 62785 108983 42449230
Antineutrophil cytoplasmic antibody positive 69.24 10.83 55 63067 4310 42553903
Neutropenia 68.43 10.83 119 63003 199312 42358901
Drug interaction 66.51 10.83 645 62477 266354 42291859
Drug ineffective 64.30 10.83 611 62511 629586 41928627
General physical health deterioration 63.88 10.83 78 63044 151168 42407045
Myocardial infarction 63.52 10.83 356 62766 123653 42434560
Pyrexia 62.57 10.83 336 62786 393706 42164507
Pulmonary fibrosis 62.02 10.83 128 62994 26553 42531660
Hyperthyroidism 61.23 10.83 90 63032 14251 42543962
Forced expiratory volume decreased 60.05 10.83 65 63057 7565 42550648
Incision site pain 51.02 10.83 33 63089 1870 42556343
Capillaritis 48.61 10.83 34 63088 2194 42556019
Vasculitis 48.47 10.83 93 63029 18301 42539912
Haemoptysis 47.05 10.83 163 62959 46004 42512209
Atrial flutter 46.41 10.83 88 63034 17163 42541050
Hypothyroidism 44.44 10.83 126 62996 31958 42526255
Dizziness 43.66 10.83 562 62560 248692 42309521
Product use in unapproved indication 43.18 10.83 135 62987 184321 42373892
Thrombosis 41.43 10.83 206 62916 68305 42489908
Atrioventricular block 40.56 10.83 60 63062 9555 42548658
Cardioplegia 38.62 10.83 7 63115 0 42558213
Atrioventricular block complete 38.33 10.83 64 63058 11300 42546913
Chronic obstructive pulmonary disease 38.33 10.83 190 62932 62924 42495289
Coronary artery disease 37.95 10.83 169 62953 53551 42504662
Toxicity to various agents 35.72 10.83 506 62616 228630 42329583
Foetal exposure during pregnancy 35.20 10.83 13 63109 47298 42510915
Device dislocation 34.67 10.83 50 63072 7781 42550432
Embolic stroke 34.62 10.83 40 63082 5000 42553213
Thrombocytopenia 34.27 10.83 155 62967 190124 42368089
Atrioventricular block first degree 34.08 10.83 45 63077 6446 42551767
Lung disorder 33.27 10.83 150 62972 47773 42510440
Subacute cutaneous lupus erythematosus 33.15 10.83 23 63099 1465 42556748
Pancytopenia 32.90 10.83 79 63043 117664 42440549
Fluid retention 32.53 10.83 112 63010 31507 42526706
Disease progression 30.94 10.83 109 63013 143547 42414666
Myelosuppression 30.30 10.83 11 63111 40450 42517763
Atrioventricular block second degree 30.06 10.83 34 63088 4153 42554060
Pulmonary arterial hypertension 29.96 10.83 54 63068 10133 42548080
Oedema peripheral 29.14 10.83 319 62803 135757 42422456
Arterial spasm 28.76 10.83 9 63113 84 42558129
Neutrophil count decreased 28.59 10.83 31 63091 63384 42494829
Mucosal inflammation 28.54 10.83 19 63103 49355 42508858
Syncope 28.11 10.83 247 62875 99159 42459054
Red blood cells urine positive 28.03 10.83 23 63099 1887 42556326
COVID-19 27.72 10.83 84 63038 115864 42442349
Sepsis 27.27 10.83 178 62944 199156 42359057
Medication error 27.05 10.83 109 63013 33045 42525168
Pacemaker generated rhythm 26.87 10.83 8 63114 62 42558151
Septic shock 26.82 10.83 60 63062 91612 42466601
Angina unstable 26.69 10.83 55 63067 11393 42546820
Tetany 26.41 10.83 18 63104 1114 42557099
Biliary cirrhosis 26.04 10.83 10 63112 179 42558034
Nodal arrhythmia 25.12 10.83 16 63106 883 42557330
Hypoperfusion 25.11 10.83 19 63103 1386 42556827
Tooth injury 24.78 10.83 18 63104 1233 42556980
Chest pain 24.53 10.83 315 62807 139215 42418998
Skin exfoliation 24.45 10.83 124 62998 41429 42516784
Antiacetylcholine receptor antibody positive 23.91 10.83 8 63114 94 42558119
Angina pectoris 23.61 10.83 104 63018 32792 42525421
Intentional product use issue 23.57 10.83 44 63078 71789 42486424
Cytokine release syndrome 23.32 10.83 19 63103 44508 42513705
International normalised ratio increased 23.12 10.83 136 62986 48032 42510181
Rhythm idioventricular 23.04 10.83 11 63111 342 42557871
Malignant neoplasm progression 22.83 10.83 83 63039 108317 42449896
Device malfunction 22.83 10.83 54 63068 12273 42545940
Diaphragmatic disorder 22.68 10.83 17 63105 1222 42556991
Product use issue 22.64 10.83 50 63072 76701 42481512
Rectal fissure 22.35 10.83 11 63111 366 42557847
Pain in extremity 22.01 10.83 329 62793 150275 42407938
Troponin increased 21.81 10.83 70 63052 18992 42539221
Sedation 21.63 10.83 9 63113 30466 42527747
Cardiac disorder 21.49 10.83 135 62987 48797 42509416
Drug resistance 21.44 10.83 12 63110 34236 42523977
Atrial thrombosis 21.33 10.83 22 63100 2422 42555791
White blood cell count decreased 21.03 10.83 88 63034 110308 42447905
Mast cell activation syndrome 20.45 10.83 10 63112 328 42557885
Agranulocytosis 20.23 10.83 10 63112 30602 42527611
Heart rate decreased 20.09 10.83 107 63015 36425 42521788
Anal haemorrhage 20.07 10.83 23 63099 2850 42555363
Optic nerve operation 19.59 10.83 11 63111 481 42557732
Influenza virus test positive 19.57 10.83 8 63114 170 42558043
Therapeutic product effect incomplete 19.39 10.83 175 62947 70764 42487449
Heart rate irregular 19.34 10.83 60 63062 15990 42542223
Gallbladder polyp 19.24 10.83 11 63111 498 42557715
Prinzmetal angina 19.21 10.83 16 63106 1341 42556872
Perineal infection 19.21 10.83 12 63110 640 42557573
Gastrointestinal haemorrhage 19.06 10.83 225 62897 97501 42460712
Bronchopulmonary aspergillosis 19.00 10.83 3 63119 19426 42538787
Cerebrovascular accident 18.64 10.83 223 62899 96937 42461276
Infection parasitic 18.46 10.83 10 63112 407 42557806
Nocturia 18.19 10.83 49 63073 12063 42546150
Sleep apnoea syndrome 17.59 10.83 71 63051 21537 42536676
Neuroleptic malignant syndrome 17.56 10.83 5 63117 21467 42536746
Incorrect route of product administration 17.54 10.83 7 63115 24298 42533915
Infected dermal cyst 17.52 10.83 13 63109 920 42557293
Hepatic cytolysis 17.39 10.83 9 63113 26835 42531378
Protein urine present 17.38 10.83 31 63091 5770 42552443
Pneumocystis jirovecii pneumonia 16.99 10.83 8 63114 25173 42533040
Arrhythmia 16.94 10.83 110 63012 40207 42518006
Perineal pain 16.71 10.83 13 63109 988 42557225
Anaemia 16.50 10.83 304 62818 279974 42278239
Scrotal infection 16.41 10.83 12 63110 831 42557382
Loss of personal independence in daily activities 16.33 10.83 128 62994 49688 42508525
Toxic optic neuropathy 16.27 10.83 13 63109 1027 42557186
Gastrointestinal bacterial infection 16.15 10.83 11 63111 680 42557533
Eczema 16.11 10.83 16 63106 34070 42524143
Adrenal insufficiency 16.07 10.83 63 63059 18861 42539352
C-reactive protein increased 15.94 10.83 45 63077 63515 42494698
Psychotic disorder 15.88 10.83 12 63110 29196 42529017
Distributive shock 15.80 10.83 19 63103 2477 42555736
Intracranial aneurysm 15.58 10.83 16 63106 1752 42556461
Inappropriate schedule of product administration 15.57 10.83 81 63041 95821 42462392
Product residue present 15.39 10.83 20 63102 2821 42555392
Angina bullosa haemorrhagica 15.16 10.83 5 63117 56 42558157
Urinary tract discomfort 15.06 10.83 6 63116 119 42558094
Eczema infected 14.92 10.83 5 63117 59 42558154
Injury 14.85 10.83 69 63053 22247 42535966
Eosinophilic pleural effusion 14.65 10.83 8 63114 331 42557882
Intentional overdose 14.61 10.83 128 62994 51328 42506885
Platelet count decreased 14.58 10.83 133 62989 138448 42419765
Lower gastrointestinal haemorrhage 14.53 10.83 42 63080 10766 42547447
Aggression 14.53 10.83 27 63095 44136 42514077
Suicidal ideation 14.51 10.83 31 63091 48130 42510083
Suicide attempt 14.46 10.83 29 63093 46071 42512142
Mast cell degranulation present 14.28 10.83 5 63117 68 42558145
Chondrocalcinosis 14.16 10.83 10 63112 655 42557558
Therapy partial responder 14.07 10.83 6 63116 20015 42538198
Brugada syndrome 14.05 10.83 12 63110 1041 42557172
Leukopenia 13.97 10.83 60 63062 74686 42483527
Nightmare 13.95 10.83 10 63112 25002 42533211
Ventricular pre-excitation 13.92 10.83 4 63118 27 42558186
Treatment failure 13.82 10.83 47 63075 62577 42495636
Arteriospasm coronary 13.78 10.83 25 63097 4713 42553500
Procedural pain 13.75 10.83 28 63094 5751 42552462
Chest discomfort 13.54 10.83 149 62973 63467 42494746
Somnolence 13.34 10.83 139 62983 140966 42417247
Hepatic function abnormal 13.31 10.83 36 63086 51531 42506682
Oliguria 13.31 10.83 37 63085 9276 42548937
Neoplasm progression 13.26 10.83 14 63108 28986 42529227
Pericardial haemorrhage 13.26 10.83 21 63101 3548 42554665
Occupational exposure to air contaminants 13.21 10.83 6 63116 166 42558047
Shock 13.19 10.83 81 63041 29040 42529173
Nodal rhythm 13.12 10.83 14 63108 1603 42556610
Arteriovenous fistula 13.12 10.83 12 63110 1140 42557073
Extrapyramidal disorder 13.09 10.83 4 63118 16408 42541805
Tendon pain 13.07 10.83 20 63102 3280 42554933
Vomiting 13.05 10.83 328 62794 289395 42268818
Infection 12.93 10.83 105 63017 111963 42446250
Adulterated product 12.90 10.83 10 63112 756 42557457
Lymphopenia 12.87 10.83 8 63114 21555 42536658
Coronary arterial stent insertion 12.85 10.83 22 63100 3963 42554250
Labyrinthitis 12.75 10.83 11 63111 967 42557246
Acquired haemophilia 12.71 10.83 14 63108 1661 42556552
Blood pressure diastolic decreased 12.70 10.83 39 63083 10336 42547877
Epilepsy 12.70 10.83 12 63110 26159 42532054
Oxygen saturation decreased 12.63 10.83 149 62973 64538 42493675
Anxiety 12.58 10.83 246 62876 118314 42439899
Neutropenic sepsis 12.52 10.83 4 63118 15942 42542271
Neurotoxicity 12.50 10.83 10 63112 23641 42534572
Emotional distress 12.41 10.83 52 63070 16041 42542172
Blood glucose increased 12.36 10.83 165 62957 73534 42484679
Acute myeloid leukaemia 12.28 10.83 9 63113 22247 42535966
Product dose omission issue 12.28 10.83 158 62964 154207 42404006
Anticoagulation drug level above therapeutic 12.15 10.83 17 63105 2573 42555640
Supraventricular tachycardia 11.94 10.83 43 63079 12365 42545848
Post streptococcal glomerulonephritis 11.90 10.83 5 63117 114 42558099
Hyperbilirubinaemia 11.84 10.83 8 63114 20627 42537586
Appendicitis 11.82 10.83 8 63114 20605 42537608
Electrocardiogram T wave biphasic 11.68 10.83 6 63116 219 42557994
Potentiating drug interaction 11.62 10.83 28 63094 6440 42551773
Hypervolaemia 11.55 10.83 66 63056 23059 42535154
Liver disorder 11.54 10.83 26 63096 39618 42518595
Dysphagia 11.48 10.83 62 63060 72657 42485556
Kounis syndrome 11.40 10.83 19 63103 3349 42554864
Restlessness 11.39 10.83 16 63106 29233 42528980
Ischaemic hepatitis 11.29 10.83 15 63107 2162 42556051
Coronary artery restenosis 11.28 10.83 10 63112 912 42557301
Inner ear disorder 11.22 10.83 6 63116 238 42557975
Infectious mononucleosis 11.17 10.83 9 63113 720 42557493
Cytopenia 11.14 10.83 6 63116 17491 42540722
Anuria 11.13 10.83 40 63082 11492 42546721
Skin tightness 11.11 10.83 15 63107 2195 42556018
Aspartate aminotransferase increased 10.99 10.83 68 63054 77095 42481118
Heart rate increased 10.99 10.83 124 62998 53131 42505082
Electrocardiogram ST segment elevation 10.98 10.83 26 63096 5913 42552300
Hypophosphataemia 10.89 10.83 9 63113 20936 42537277
Nephrogenic systemic fibrosis 10.86 10.83 19 63103 3482 42554731

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1109.99 9.66 1695 187579 240686 110159339
Creatinine renal clearance decreased 614.94 9.66 412 188862 21403 110378622
Sedation complication 598.49 9.66 391 188883 19464 110380561
Atrial fibrillation 579.66 9.66 1240 188034 228402 110171623
Bradycardia 508.37 9.66 936 188338 154581 110245444
Hypotension 470.97 9.66 1958 187316 521891 109878134
Blood calcium decreased 424.81 9.66 407 188867 35438 110364587
Orthostatic hypotension 415.12 9.66 539 188735 65710 110334315
Off label use 377.54 9.66 1314 187960 1498871 108901154
Cardiac failure congestive 367.72 9.66 804 188470 150196 110249829
Balance disorder 363.88 9.66 688 188586 115872 110284153
Suspected suicide 306.16 9.66 234 189040 14965 110385060
Toxicity to various agents 276.84 9.66 1582 187692 478973 109921052
Sedation 264.46 9.66 448 188826 69235 110330790
Cognitive disorder 254.04 9.66 501 188773 87010 110313015
Dyspnoea 234.97 9.66 2907 186367 1103965 109296060
Neutropenia 216.98 9.66 193 189081 374427 110025598
Drug ineffective 210.91 9.66 1633 187641 1518907 108881118
Depressed level of consciousness 210.42 9.66 540 188734 111738 110288287
Conjunctivitis allergic 205.21 9.66 135 189139 6796 110393229
Spirometry abnormal 200.06 9.66 122 189152 5375 110394650
Febrile neutropenia 197.26 9.66 152 189122 316615 110083410
Mite allergy 193.97 9.66 122 189152 5681 110394344
Mycotic allergy 193.59 9.66 123 189151 5831 110394194
Dust allergy 192.70 9.66 123 189151 5878 110394147
BRASH syndrome 178.97 9.66 99 189175 3624 110396401
Fall 157.75 9.66 1652 187622 601830 109798195
Asthma 137.33 9.66 814 188460 249477 110150548
Full blood count abnormal 136.94 9.66 299 188975 55753 110344272
Atrioventricular block complete 136.18 9.66 170 189104 19912 110380113
Cardiogenic shock 134.60 9.66 301 188973 57037 110342988
Arteriosclerosis coronary artery 126.57 9.66 184 189090 24934 110375091
Urinary tract discomfort 124.83 9.66 51 189223 929 110399096
Pulmonary vasculitis 123.41 9.66 97 189177 6463 110393562
Normochromic normocytic anaemia 121.29 9.66 130 189144 12927 110387098
Alveolar osteitis 113.23 9.66 49 189225 1036 110398989
Systemic lupus erythematosus rash 111.44 9.66 59 189215 1976 110398049
Drug interaction 109.12 9.66 1322 187952 498861 109901164
Obstructive airways disorder 108.02 9.66 242 189032 45907 110354118
Myelosuppression 106.25 9.66 17 189257 94323 110305702
Neuritis 105.11 9.66 93 189181 7306 110392719
Hypoxia 103.56 9.66 468 188806 129047 110270978
Chest pain 100.84 9.66 1036 188238 375339 110024686
Arteriosclerosis 93.63 9.66 159 189115 24608 110375417
Productive cough 93.61 9.66 416 188858 113889 110286136
Forced expiratory volume decreased 93.30 9.66 114 189160 13062 110386963
Tunnel vision 92.54 9.66 52 189222 1963 110398062
Pancytopenia 91.94 9.66 135 189139 209478 110190547
Cardiac arrest 91.76 9.66 614 188660 196139 110203886
Atrioventricular block second degree 91.47 9.66 90 189184 8091 110391934
Bladder pain 91.33 9.66 58 189216 2747 110397278
Dyspnoea exertional 90.78 9.66 386 188888 103674 110296351
Eosinophilic granulomatosis with polyangiitis 89.90 9.66 101 189173 10585 110389440
Maternal exposure during pregnancy 89.31 9.66 189 189085 254694 110145331
Animal scratch 88.17 9.66 49 189225 1810 110398215
Myocardial infarction 87.53 9.66 596 188678 191487 110208538
Oedema peripheral 85.80 9.66 900 188374 327760 110072265
Atrial flutter 84.21 9.66 150 189124 24112 110375913
Malignant neoplasm progression 82.00 9.66 107 189167 174460 110225565
Medication error 80.71 9.66 376 188898 104990 110295035
Rash 79.93 9.66 960 188314 820004 109580021
Fluid retention 79.33 9.66 346 188928 93961 110306064
Disease progression 78.94 9.66 189 189085 243845 110156180
Pulmonary arterial hypertension 77.58 9.66 172 189102 32396 110367629
Nerve injury 76.36 9.66 93 189181 10620 110389405
Heart rate increased 75.14 9.66 462 188812 143372 110256653
Ear congestion 75.07 9.66 57 189217 3608 110396417
Paranasal sinus discomfort 74.49 9.66 72 189202 6333 110393692
White blood cell count decreased 73.92 9.66 178 189096 229212 110170813
General physical health deterioration 73.92 9.66 426 188848 424869 109975156
Chronic obstructive pulmonary disease 73.90 9.66 376 188898 108782 110291243
Neutrophil count decreased 72.75 9.66 60 189214 120881 110279144
Body tinea 72.04 9.66 45 189229 2070 110397955
Total lung capacity abnormal 71.97 9.66 61 189213 4522 110395503
Creatinine renal clearance increased 71.23 9.66 55 189219 3570 110396455
Mucosal inflammation 70.90 9.66 38 189236 96103 110303922
Constipation 69.58 9.66 926 188348 356860 110043165
Product use issue 68.71 9.66 287 188987 311408 110088617
Atrioventricular block 68.68 9.66 112 189162 16765 110383260
Inhibitory drug interaction 67.93 9.66 61 189213 4886 110395139
Coronary artery disease 67.29 9.66 272 189002 71418 110328607
Labile blood pressure 65.64 9.66 45 189229 2426 110397599
Gastrointestinal procedural complication 65.45 9.66 26 189248 439 110399586
Treatment failure 65.07 9.66 249 189025 276985 110123040
Pyrexia 65.01 9.66 1114 188160 897151 109502874
Neurological symptom 64.09 9.66 104 189170 15504 110384521
Atrioventricular block first degree 62.84 9.66 98 189176 14127 110385898
Nephrolithiasis 61.97 9.66 251 189023 65961 110334064
Pericardial haemorrhage 61.34 9.66 59 189215 5158 110394867
Product use in unapproved indication 61.28 9.66 481 188793 446896 109953129
Wound complication 60.03 9.66 63 189211 6114 110393911
Gastrointestinal haemorrhage 59.72 9.66 486 188788 165032 110234993
Heart rate decreased 59.51 9.66 290 188984 82466 110317559
Blood iron decreased 59.39 9.66 113 189161 19101 110380924
Infusion related reaction 59.36 9.66 395 188879 380767 110019258
Respiratory symptom 59.23 9.66 98 189176 14847 110385178
Antineutrophil cytoplasmic antibody positive 57.05 9.66 56 189218 5020 110395005
Death 56.86 9.66 1582 187692 697287 109702738
Myopathy 56.31 9.66 129 189145 24831 110375194
Rales 55.96 9.66 128 189146 24611 110375414
Angina pectoris 55.82 9.66 233 189041 62062 110337963
Pulmonary alveolar haemorrhage 55.61 9.66 113 189161 20037 110379988
Vomiting 54.63 9.66 1166 188108 909509 109490516
Arthropathy 53.76 9.66 281 188993 287241 110112784
Sleep disorder due to a general medical condition 53.18 9.66 203 189071 51909 110348116
Epilepsy 52.86 9.66 56 189218 100153 110299872
Polymyalgia rheumatica 52.68 9.66 60 189214 6382 110393643
Nodal rhythm 52.61 9.66 45 189229 3378 110396647
COVID-19 51.94 9.66 229 189045 244831 110155194
Hunger 51.47 9.66 60 189214 6544 110393481
Mobility decreased 51.43 9.66 627 188647 236795 110163230
Pulmonary congestion 50.97 9.66 142 189132 30824 110369201
Agranulocytosis 50.78 9.66 21 189253 61739 110338286
Bunion operation 50.71 9.66 27 189247 915 110399110
Thrombocytopenia 50.65 9.66 369 188905 348516 110051509
C-reactive protein increased 50.31 9.66 197 189077 217722 110182303
Sinus pain 50.20 9.66 56 189218 5823 110394202
Limb injury 50.01 9.66 160 189114 37476 110362549
Drug resistance 49.99 9.66 17 189257 56357 110343668
Alveolitis 49.94 9.66 49 189225 4390 110395635
Leukopenia 49.89 9.66 113 189161 148678 110251347
Synovitis 49.51 9.66 271 189003 273821 110126204
Injection site erythema 49.26 9.66 53 189221 94123 110305902
Mesenteric haematoma 48.84 9.66 14 189260 79 110399946
Renal function test abnormal 48.70 9.66 68 189206 8878 110391147
Cytokine release syndrome 48.68 9.66 30 189244 70276 110329749
Heart sounds 48.47 9.66 28 189246 1115 110398910
Infection susceptibility increased 48.46 9.66 48 189226 4350 110395675
Anti-cyclic citrullinated peptide antibody 48.19 9.66 106 189168 19858 110380167
Drug intolerance 48.09 9.66 454 188820 406058 109993967
Pain in extremity 47.87 9.66 1131 188143 485987 109914038
Incision site pain 47.75 9.66 41 189233 3094 110396931
Porphyria acute 45.66 9.66 100 189174 18680 110381345
Septic shock 45.57 9.66 129 189145 157399 110242626
Cardiac disorder 44.98 9.66 253 189021 76027 110323998
Platelet count decreased 44.90 9.66 222 189052 230221 110169804
Blood pressure systolic increased 44.87 9.66 269 189005 82722 110317303
Pain in jaw 44.75 9.66 190 189084 50987 110349038
Dizziness 44.41 9.66 1534 187740 696659 109703366
Syncope 43.91 9.66 535 188739 202001 110198024
X-ray abnormal 43.53 9.66 154 189120 37963 110362062
Prolonged expiration 42.98 9.66 29 189245 1523 110398502
Nodal arrhythmia 42.61 9.66 33 189241 2151 110397874
Cerebrovascular accident 42.45 9.66 486 188788 180798 110219227
Unevaluable event 42.19 9.66 207 189067 59020 110341005
Bronchitis 41.86 9.66 432 188842 156600 110243425
Ischaemic contracture of the left ventricle 41.70 9.66 14 189260 142 110399883
Capillaritis 41.49 9.66 34 189240 2405 110397620
Wound secretion 41.42 9.66 55 189219 6846 110393179
Therapy partial responder 41.01 9.66 7 189267 37054 110362971
Aspartate aminotransferase increased 40.58 9.66 139 189135 159797 110240228
Pulmonary fibrosis 40.30 9.66 306 188968 101736 110298289
Coeliac disease 40.11 9.66 12 189262 43175 110356850
Blood urine present 39.73 9.66 111 189163 24134 110375891
Therapeutic product effect decreased 39.63 9.66 250 189024 244066 110155959
Angina unstable 39.38 9.66 87 189187 16345 110383680
Alanine aminotransferase increased 39.37 9.66 171 189103 183602 110216423
International normalised ratio increased 39.35 9.66 269 189005 86503 110313522
Lower limb fracture 39.32 9.66 242 189032 75106 110324919
Respiratory tract congestion 39.03 9.66 129 189145 30728 110369297
Poor quality sleep 38.81 9.66 121 189153 27956 110372069
Hyperthyroidism 38.52 9.66 124 189150 29137 110370888
Arteriospasm coronary 37.86 9.66 61 189213 9039 110390986
Bladder prolapse 37.69 9.66 26 189248 1416 110398609
Foot deformity 37.11 9.66 173 189101 48307 110351718
Nausea 36.35 9.66 1737 187537 1233953 109166072
Hepatic ischaemia 36.14 9.66 24 189250 1227 110398798
Suicidal ideation 36.04 9.66 66 189208 93871 110306154
Hepatic enzyme increased 35.99 9.66 363 188911 320529 110079496
Nodule 35.70 9.66 130 189144 32501 110367524
Joint swelling 35.67 9.66 538 188736 442307 109957718
Onychomadesis 35.23 9.66 17 189257 45646 110354379
Sepsis 35.20 9.66 374 188900 326972 110073053
Exposure during pregnancy 35.13 9.66 157 189117 167267 110232758
Intentional product use issue 35.10 9.66 264 189010 247642 110152383
Status epilepticus 34.85 9.66 6 189268 31565 110368460
Abortion spontaneous 34.74 9.66 8 189266 34274 110365751
Erythema 34.66 9.66 325 188949 291122 110108903
Bronchopulmonary aspergillosis 34.49 9.66 5 189269 29858 110370167
Myocardial hypoxia 34.22 9.66 8 189266 16 110400009
Embolic stroke 34.20 9.66 57 189217 8686 110391339
Kidney infection 34.17 9.66 109 189165 25490 110374535
Pemphigus 34.06 9.66 221 189053 214349 110185676
Hypervolaemia 33.91 9.66 171 189103 49289 110350736
Pericarditis 33.62 9.66 228 189046 218886 110181139
Feeling cold 33.54 9.66 131 189143 33856 110366169
Skin laceration 33.22 9.66 130 189144 33623 110366402
Muscle relaxant therapy 32.79 9.66 12 189262 160 110399865
Wheezing 32.64 9.66 616 188658 254614 110145411
Multiple drug therapy 32.36 9.66 53 189221 7961 110392064
Hepatic cytolysis 32.26 9.66 28 189246 55025 110345000
Blepharospasm 32.02 9.66 28 189246 54823 110345202
Cardioplegia 31.83 9.66 7 189267 9 110400016
Haemoptysis 31.64 9.66 220 189054 71134 110328891
Oxygen saturation decreased 31.59 9.66 409 188865 156573 110243452
Rheumatoid arthritis 31.53 9.66 344 188930 299269 110100756
Cytomegalovirus infection 31.53 9.66 28 189246 54416 110345609
Hepatic function abnormal 31.43 9.66 66 189208 89229 110310796
Cellulitis 31.39 9.66 342 188932 125674 110274351
Oedema 31.20 9.66 519 188755 209457 110190568
Dysphagia 31.06 9.66 146 189128 153454 110246571
Red blood cell sedimentation rate abnormal 31.04 9.66 3 189271 24506 110375519
Psychotic disorder 30.96 9.66 25 189249 50912 110349113
Transfusion 30.90 9.66 105 189169 25367 110374658
Haemophagocytic lymphohistiocytosis 30.74 9.66 8 189266 31551 110368474
Pulmonary hypertension 30.50 9.66 180 189094 55040 110344985
Palpitations 30.46 9.66 411 188863 158801 110241224
Sinus bradycardia 30.20 9.66 115 189159 29368 110370657
Neutropenic sepsis 29.56 9.66 8 189266 30738 110369287
Psoriatic arthropathy 29.56 9.66 206 189068 196555 110203470
Glucose tolerance impaired 29.35 9.66 57 189217 9780 110390245
Hepatitis 28.90 9.66 70 189204 89984 110310041
Supraventricular tachycardia 28.17 9.66 99 189175 24323 110375702
Disturbance in attention 28.08 9.66 39 189235 61956 110338069
Erythrodermic psoriasis 28.03 9.66 25 189249 1985 110398040
Distributive shock 27.94 9.66 42 189232 5862 110394163
Anaphylactic reaction 27.88 9.66 101 189173 114199 110285826
Alopecia 27.71 9.66 448 188826 364305 110035720
Finger deformity 27.62 9.66 11 189263 33081 110366944
Heart rate irregular 27.49 9.66 124 189150 34150 110365875
Neuroleptic malignant syndrome 27.33 9.66 12 189262 34047 110365978
Prinzmetal angina 27.32 9.66 26 189248 2243 110397782
Arthralgia 27.20 9.66 1075 188199 778557 109621468
Pulmonary oedema 26.86 9.66 277 188997 100382 110299643
Taste disorder 26.85 9.66 44 189230 65343 110334682
Cough 26.77 9.66 1004 188270 460637 109939388
Bone marrow failure 26.60 9.66 36 189238 57812 110342213
Hyperkalaemia 26.57 9.66 352 188922 135444 110264581
Torsade de pointes 26.40 9.66 92 189182 22508 110377517
Blood bilirubin increased 26.03 9.66 57 189217 75915 110324110
Hyperbilirubinaemia 25.92 9.66 10 189264 30661 110369364
Lower gastrointestinal haemorrhage 25.86 9.66 80 189194 18406 110381619
Coronary artery bypass 25.82 9.66 41 189233 6001 110394024
Thrombosis 25.74 9.66 292 188982 108370 110291655
Sebaceous gland infection 25.72 9.66 10 189264 159 110399866
Weight decreased 25.49 9.66 1011 188263 467046 109932979
Cardiac ablation 25.43 9.66 27 189247 2655 110397370
Bronchopulmonary aspergillosis allergic 25.36 9.66 49 189225 8377 110391648
Pacemaker generated rhythm 25.29 9.66 8 189266 66 110399959
Systemic lupus erythematosus 25.19 9.66 296 188978 254042 110145983
Neoplasm progression 25.12 9.66 45 189229 64550 110335475
Hypokinesia 24.77 9.66 88 189186 21738 110378287
Onychomycosis 24.58 9.66 18 189256 38513 110361512
Polyneuropathy 24.57 9.66 12 189262 32000 110368025
Schizophrenia 24.42 9.66 4 189270 21822 110378203
Anaemia 24.23 9.66 732 188542 546354 109853671
Lymphopenia 24.06 9.66 20 189254 40150 110359875
Acute myeloid leukaemia 24.06 9.66 18 189256 38092 110361933
Tooth infection 23.88 9.66 88 189186 22128 110377897
Inappropriate schedule of product administration 23.81 9.66 228 189046 203409 110196616
Nail disorder 23.77 9.66 39 189235 57896 110342129
Abdominal pain 23.56 9.66 683 188591 512306 109887719
Contusion 23.54 9.66 544 188730 232817 110167208
Allergy to venom 23.40 9.66 5 189269 5 110400020
No adverse event 23.22 9.66 58 189216 73781 110326244
Rectal prolapse 22.90 9.66 25 189249 2538 110397487
Arrhythmia 22.80 9.66 200 189074 69375 110330650
Wound 22.77 9.66 274 189000 234163 110165862
Abdominal discomfort 22.74 9.66 507 188767 393351 110006674
Anti-cyclic citrullinated peptide antibody positive 22.46 9.66 201 189073 181783 110218242
Biliary cirrhosis 22.26 9.66 10 189264 232 110399793
Aplastic anaemia 22.13 9.66 7 189267 24301 110375724
Wrong technique in product usage process 22.09 9.66 76 189198 87272 110312753
Arteriovenous fistula occlusion 22.09 9.66 13 189261 536 110399489
Arterial spasm 22.03 9.66 9 189265 164 110399861
Epstein-Barr virus infection 21.96 9.66 3 189271 18735 110381290
Blue toe syndrome 21.84 9.66 14 189260 674 110399351
Hypoacusis 21.60 9.66 118 189156 35073 110364952
Injection site pruritus 21.51 9.66 34 189240 51224 110348801
Aggression 21.49 9.66 43 189231 59167 110340858
Serotonin syndrome 21.43 9.66 43 189231 59110 110340915
Appendicitis 21.35 9.66 11 189263 28453 110371572
Presyncope 21.25 9.66 150 189124 48737 110351288
Blood pressure diastolic decreased 21.14 9.66 119 189155 35766 110364259
Thermal burn 21.11 9.66 44 189230 7944 110392081
Suicide attempt 21.06 9.66 98 189176 103296 110296729
Drug reaction with eosinophilia and systemic symptoms 21.06 9.66 71 189203 82024 110318001
Gamma-glutamyltransferase increased 21.01 9.66 46 189228 61263 110338762
Metastases to bone 20.88 9.66 14 189260 31358 110368667
Interstitial lung disease 20.86 9.66 146 189128 139188 110260837
Neuropathy peripheral 20.84 9.66 201 189073 179076 110220949
Oxygen consumption increased 20.83 9.66 36 189238 5649 110394376
Intentional self-injury 20.78 9.66 20 189254 37409 110362616
Hyperglycaemia 20.76 9.66 230 189044 84860 110315165
Disseminated intravascular coagulation 20.75 9.66 24 189250 41262 110358763
Atrial thrombosis 20.69 9.66 31 189243 4315 110395710
Cytopenia 20.64 9.66 13 189261 30103 110369922
Aspergillus infection 20.60 9.66 9 189265 25607 110374418
Hepatotoxicity 20.56 9.66 49 189225 63351 110336674
Transaminases increased 20.55 9.66 49 189225 63341 110336684
Coagulopathy 20.47 9.66 130 189144 40781 110359244
Hypertension 20.30 9.66 692 188582 509392 109890633
Restlessness 20.29 9.66 41 189233 56218 110343807
Pneumocystis jirovecii pneumonia 20.26 9.66 26 189248 42709 110357316
Deep vein thrombosis 20.25 9.66 148 189126 139739 110260286
Incision site haemorrhage 20.15 9.66 16 189258 1082 110398943
Paraesthesia oral 19.88 9.66 17 189257 33654 110366371
Gravitational oedema 19.60 9.66 20 189254 1878 110398147
Multiple sclerosis relapse 19.53 9.66 35 189239 50205 110349820
Drug ineffective for unapproved indication 19.49 9.66 100 189174 102738 110297287
Cardiac failure 19.42 9.66 439 188835 187187 110212838
Cardiac pacemaker insertion 19.40 9.66 37 189237 6264 110393761
Drug-induced liver injury 19.39 9.66 123 189151 119944 110280081
Nephroangiosclerosis 19.32 9.66 11 189263 426 110399599
Fibrous histiocytoma 19.32 9.66 14 189260 825 110399200
Tendon pain 19.30 9.66 37 189237 6289 110393736
Lung disorder 19.19 9.66 423 188851 179624 110220401
Device pacing issue 18.99 9.66 8 189266 158 110399867
Cardioactive drug level increased 18.92 9.66 28 189246 3854 110396171
Aphasia 18.82 9.66 46 189228 58951 110341074
Generalised tonic-clonic seizure 18.76 9.66 41 189233 54639 110345386
Drug use disorder 18.75 9.66 4 189270 18070 110381955
Calculus urinary 18.73 9.66 25 189249 3127 110396898
Liver injury 18.62 9.66 166 189108 150247 110249778
Musculoskeletal stiffness 18.58 9.66 352 188922 279470 110120555
Lupus vulgaris 18.42 9.66 110 189164 33773 110366252
Palmar-plantar erythrodysaesthesia syndrome 18.39 9.66 26 189248 40999 110359026
Seizure 18.38 9.66 267 189007 220918 110179107
Chronic sinusitis 18.36 9.66 10 189264 25074 110374951
Pollakiuria 18.28 9.66 134 189140 44061 110355964
Bladder disorder 18.26 9.66 51 189223 11086 110388939
Abnormal behaviour 18.25 9.66 24 189250 39015 110361010
Progressive multifocal leukoencephalopathy 18.20 9.66 10 189264 24946 110375079
Respiration abnormal 18.18 9.66 47 189227 9762 110390263
Peak expiratory flow rate abnormal 18.14 9.66 7 189267 109 110399916
Myocardial ischaemia 18.11 9.66 92 189182 26592 110373433
Optic nerve operation 18.07 9.66 11 189263 483 110399542
Wrist fracture 17.99 9.66 60 189214 14357 110385668
Diaphragmatic disorder 17.91 9.66 19 189255 1867 110398158
Electrocardiogram QRS complex prolonged 17.89 9.66 56 189218 12965 110387060
Posterior reversible encephalopathy syndrome 17.77 9.66 19 189255 33842 110366183
Umbilical hernia 17.76 9.66 38 189236 6984 110393041
Extrapyramidal disorder 17.76 9.66 14 189260 28853 110371172
Hypercalcaemia 17.70 9.66 33 189241 46624 110353401
Atrioventricular dissociation 17.64 9.66 10 189264 384 110399641
Carbon dioxide increased 17.59 9.66 23 189251 2821 110397204
Sopor 17.57 9.66 22 189252 36524 110363501
Blood loss anaemia 17.40 9.66 69 189205 17956 110382069
Anaphylactic shock 17.39 9.66 39 189235 51507 110348518
Intentional product misuse 17.20 9.66 145 189129 132759 110267266
Hypoaesthesia oral 17.15 9.66 66 189208 16936 110383089
Chondrocalcinosis 17.11 9.66 19 189255 1966 110398059
Thrombotic microangiopathy 16.87 9.66 15 189259 29134 110370891
Inflammation 16.85 9.66 231 189043 193007 110207018
Metastases to central nervous system 16.85 9.66 9 189265 22808 110377217
Brain oedema 16.83 9.66 17 189257 31081 110368944
Respiratory acidosis 16.78 9.66 57 189217 13769 110386256
Hemiparesis 16.70 9.66 31 189243 43872 110356153
Bezoar 16.63 9.66 27 189247 4027 110395998
Skin necrosis 16.61 9.66 8 189266 21504 110378521
Erythromelalgia 16.55 9.66 10 189264 433 110399592
Nasal polyps 16.53 9.66 55 189219 13145 110386880
Bradyarrhythmia 16.48 9.66 30 189244 4904 110395121
Osteonecrosis of jaw 16.47 9.66 36 189238 47981 110352044
Female genital tract fistula 16.45 9.66 4 189270 16515 110383510
Cytomegalovirus viraemia 16.38 9.66 5 189269 17759 110382266
Liver function test increased 16.28 9.66 87 189187 88461 110311564
Catheter site haemorrhage 16.26 9.66 33 189241 5847 110394178
Mental disorder 16.02 9.66 26 189248 38765 110361260
Intracranial aneurysm 16.02 9.66 30 189244 5010 110395015
Febrile bone marrow aplasia 15.95 9.66 5 189269 17460 110382565
Arrhythmogenic right ventricular dysplasia 15.94 9.66 6 189268 87 110399938
Acute coronary syndrome 15.91 9.66 80 189194 23032 110376993
Immune effector cell-associated neurotoxicity syndrome 15.90 9.66 3 189271 14779 110385246
Stent placement 15.89 9.66 37 189237 7197 110392828
Amaurosis fugax 15.83 9.66 20 189254 2370 110397655
Acute lung injury 15.75 9.66 23 189251 3128 110396897
Metastases to lung 15.75 9.66 10 189264 23053 110376972
Scrotal infection 15.69 9.66 12 189262 768 110399257
Rhythm idioventricular 15.62 9.66 12 189262 773 110399252
Gouty tophus 15.61 9.66 10 189264 481 110399544
Humidity intolerance 15.44 9.66 10 189264 490 110399535
Red blood cells urine positive 15.42 9.66 30 189244 5155 110394870
Escherichia infection 15.36 9.66 11 189263 23805 110376220
Hospitalisation 15.25 9.66 335 188939 142158 110257867
Vocal cord operation 15.17 9.66 6 189268 100 110399925
Haemorrhagic stroke 15.14 9.66 55 189219 13734 110386291
Post transplant lymphoproliferative disorder 15.13 9.66 4 189270 15609 110384416
Contraindicated product administered 15.07 9.66 317 188957 247950 110152075
Road traffic accident 15.05 9.66 263 189011 107135 110292890
Neurotoxicity 15.02 9.66 31 189243 42176 110357849
Thyrotoxic crisis 15.01 9.66 18 189256 2022 110398003
Antiacetylcholine receptor antibody positive 15 9.66 8 189266 272 110399753
Stomatitis 14.99 9.66 350 188924 269892 110130133
Aortic arteriosclerosis 14.99 9.66 47 189227 10891 110389134
Coronary arterial stent insertion 14.95 9.66 32 189242 5883 110394142
Rectal haemorrhage 14.89 9.66 288 188986 119545 110280480
Motor dysfunction 14.81 9.66 12 189262 24394 110375631
Heart rate abnormal 14.79 9.66 36 189238 7202 110392823
Joint injury 14.72 9.66 118 189156 39876 110360149
Cardioversion 14.70 9.66 19 189255 2304 110397721
Cerebellar syndrome 14.69 9.66 33 189241 6269 110393756
Blood pressure inadequately controlled 14.59 9.66 37 189237 7596 110392429
Perineal infection 14.57 9.66 12 189262 855 110399170
Device malfunction 14.56 9.66 84 189190 25474 110374551
Anuria 14.52 9.66 81 189193 24260 110375765
Pulseless electrical activity 14.48 9.66 62 189212 16695 110383330
Myalgia 14.43 9.66 490 188784 221891 110178134
Hyperlipidaemia 14.43 9.66 108 189166 35740 110364285
Ventricular arrhythmia 14.43 9.66 44 189230 10043 110389982
Miosis 14.38 9.66 10 189264 21973 110378052
Cholangitis 14.35 9.66 5 189269 16330 110383695
Sinoatrial block 14.34 9.66 15 189259 1450 110398575
Peritonitis 14.29 9.66 21 189253 32586 110367439
Tenosynovitis 14.28 9.66 5 189269 16278 110383747
Aortic stenosis 14.26 9.66 52 189222 13007 110387018
Peripheral swelling 14.20 9.66 836 188438 403198 109996827
Hypoperfusion 14.17 9.66 22 189252 3159 110396866
Oropharyngeal pain 14.15 9.66 317 188957 134959 110265066
Aspiration pleural cavity 13.90 9.66 16 189258 1721 110398304
Nasal congestion 13.88 9.66 241 189033 98041 110301984
Eczema 13.87 9.66 70 189204 72223 110327802
Bacterial infection 13.83 9.66 37 189237 45999 110354026
Antidepressant drug level above therapeutic 13.82 9.66 11 189263 746 110399279
Renal injury 13.75 9.66 66 189208 18647 110381378
Diffuse large B-cell lymphoma 13.74 9.66 5 189269 15893 110384132
Toxic optic neuropathy 13.73 9.66 14 189260 1314 110398711
Tooth disorder 13.68 9.66 92 189182 29417 110370608
Jaundice cholestatic 13.67 9.66 4 189270 14604 110385421
Tooth injury 13.63 9.66 18 189256 2228 110397797
Mast cell degranulation present 13.57 9.66 5 189269 68 110399957
Drug dose omission by device 13.54 9.66 4 189270 14512 110385513
Acute generalised exanthematous pustulosis 13.53 9.66 73 189201 21591 110378434
Injection site swelling 13.53 9.66 57 189217 61733 110338292
Colitis 13.52 9.66 111 189163 102212 110297813
Electrocardiogram U wave present 13.52 9.66 6 189268 135 110399890
Hypovolaemia 13.52 9.66 73 189201 21601 110378424
Incorrect route of product administration 13.48 9.66 60 189214 64001 110336024
Haemarthrosis 13.46 9.66 35 189239 7294 110392731
Sinus node dysfunction 13.45 9.66 40 189234 9007 110391018
Muscle strain 13.43 9.66 46 189228 11156 110388869
Parotid gland enlargement 13.37 9.66 13 189261 1152 110398873
Ventricular pre-excitation 13.34 9.66 4 189270 27 110399998
Tumour lysis syndrome 13.34 9.66 20 189254 30781 110369244
Troponin increased 13.33 9.66 92 189182 29674 110370351
Hypogammaglobulinaemia 13.31 9.66 9 189265 20067 110379958
Vasculitis 13.29 9.66 106 189168 35767 110364258
Renal pain 13.28 9.66 42 189232 9775 110390250
Pneumonia 13.20 9.66 1703 187571 875011 109525014
Shock 13.14 9.66 145 189129 53443 110346582
Coronary artery restenosis 13.12 9.66 13 189261 1179 110398846
Asphyxia 13.11 9.66 4 189270 14211 110385814
Hypophosphataemia 13.01 9.66 23 189251 33159 110366866
Bundle branch block left 12.98 9.66 50 189224 12838 110387187
Gastrointestinal bacterial infection 12.96 9.66 14 189260 1404 110398621
Pancreatitis acute 12.95 9.66 56 189218 60218 110339807
Hepatorenal syndrome 12.95 9.66 26 189248 4571 110395454
Laryngitis 12.92 9.66 120 189154 42291 110357734
Blood pressure diastolic abnormal 12.89 9.66 82 189192 25733 110374292
Blood test abnormal 12.89 9.66 18 189256 28536 110371489
Sinus disorder 12.84 9.66 98 189176 32630 110367395
Affect lability 12.83 9.66 8 189266 18629 110381396
Hyperphosphataemia 12.79 9.66 6 189268 16375 110383650
Product label confusion 12.73 9.66 12 189262 22665 110377360
Candida infection 12.67 9.66 41 189233 47968 110352057
COVID-19 pneumonia 12.62 9.66 28 189246 37115 110362910
Ataxia 12.60 9.66 20 189254 30088 110369937
Coronary artery occlusion 12.60 9.66 57 189217 15715 110384310
Immune thrombocytopenia 12.51 9.66 12 189262 22482 110377543
Oral papilloma 12.50 9.66 5 189269 86 110399939
Injection site urticaria 12.40 9.66 7 189267 17208 110382817
Occupational exposure to air contaminants 12.38 9.66 6 189268 166 110399859
Catheter site erythema 12.34 9.66 30 189244 5998 110394027
Gallbladder polyp 12.28 9.66 13 189261 1274 110398751
Infection parasitic 12.23 9.66 11 189263 883 110399142
Rebound effect 12.23 9.66 5 189269 14801 110385224
Infective pulmonary exacerbation of cystic fibrosis 12.18 9.66 5 189269 14766 110385259
Cardiac valve disease 12.14 9.66 31 189243 6390 110393635
Myelodysplastic syndrome 12.13 9.66 29 189245 37455 110362570
Movement disorder 12.11 9.66 105 189169 36299 110363726
Adverse reaction 12.07 9.66 20 189254 29574 110370451
Drug hypersensitivity 11.98 9.66 645 188629 453445 109946580
Perineal pain 11.98 9.66 14 189260 1531 110398494
Histamine abnormal 11.97 9.66 3 189271 9 110400016
Vaginal discharge 11.91 9.66 8 189266 17900 110382125
Haematuria 11.89 9.66 204 189070 82801 110317224
Colon gangrene 11.79 9.66 4 189270 42 110399983
Infected dermal cyst 11.78 9.66 13 189261 1335 110398690
Electrocardiogram QT shortened 11.76 9.66 7 189267 295 110399730
Nephropathy toxic 11.74 9.66 18 189256 27460 110372565
Duodenal ulcer perforation 11.65 9.66 224 189050 177476 110222549
Pharyngeal cyst 11.63 9.66 5 189269 104 110399921
Myocarditis 11.63 9.66 21 189253 30034 110369991
Anal haemorrhage 11.62 9.66 26 189248 4926 110395099
Appetite disorder 11.61 9.66 40 189234 9729 110390296
Gingival hypertrophy 11.61 9.66 24 189250 4307 110395718
Uveitis 11.60 9.66 12 189262 21698 110378327
Diverticulum 11.58 9.66 55 189219 15471 110384554
Catheter management 11.58 9.66 22 189252 3713 110396312
Pulmonary function test decreased 11.57 9.66 37 189237 8663 110391362
Hallucination, auditory 11.57 9.66 17 189257 26380 110373645
Renal failure 11.53 9.66 486 188788 226088 110173937
Back injury 11.48 9.66 42 189232 47357 110352668
Haematemesis 11.47 9.66 153 189121 58955 110341070
Ill-defined disorder 11.45 9.66 194 189080 156659 110243366
Muscle disorder 11.38 9.66 31 189243 6641 110393384
Condition aggravated 11.36 9.66 1093 188181 733743 109666282
Seasonal allergy 11.35 9.66 65 189209 19657 110380368
Adjustment disorder with depressed mood 11.34 9.66 120 189154 43763 110356262
Premature delivery 11.33 9.66 22 189252 30610 110369415
Sensory loss 11.30 9.66 12 189262 21445 110378580
Injection site warmth 11.27 9.66 8 189266 17397 110382628
Ascites 11.23 9.66 103 189171 92705 110307320
Motion sickness 11.23 9.66 12 189262 1189 110398836
Mood altered 11.21 9.66 12 189262 21363 110378662
Nocturia 11.13 9.66 58 189216 16932 110383093
Immune reconstitution inflammatory syndrome 11.13 9.66 7 189267 16219 110383806
Ectopic ACTH syndrome 11.12 9.66 6 189268 209 110399816
Vasoplegia syndrome 11.06 9.66 27 189247 5412 110394613
Post streptococcal glomerulonephritis 11.05 9.66 5 189269 118 110399907
Mitral valve incompetence 11.02 9.66 96 189178 33233 110366792
Metastases to lymph nodes 10.99 9.66 6 189268 15026 110384999
Metastases to liver 10.97 9.66 28 189246 35358 110364667
Dermatitis acneiform 10.96 9.66 4 189270 12691 110387334
Enlarged uvula 10.94 9.66 8 189266 478 110399547
Blood lactate dehydrogenase increased 10.92 9.66 39 189235 44295 110355730
Nephrogenic systemic fibrosis 10.92 9.66 27 189247 5456 110394569
Acidosis 10.90 9.66 71 189203 22460 110377565
Anion gap abnormal 10.87 9.66 10 189264 826 110399199
Toxic epidermal necrolysis 10.84 9.66 55 189219 56672 110343353
Abscess 10.80 9.66 19 189255 27450 110372575
Weight abnormal 10.80 9.66 16 189258 2205 110397820
Arteriovenous fistula 10.76 9.66 13 189261 1472 110398553
Proctitis 10.68 9.66 8 189266 16919 110383106
Product quality issue 10.61 9.66 83 189191 77216 110322809
Hyperaesthesia 10.60 9.66 6 189268 14721 110385304
Influenza virus test positive 10.58 9.66 8 189266 503 110399522
Encephalitis 10.54 9.66 10 189264 18829 110381196
Optic neuritis 10.53 9.66 3 189271 11144 110388881
Device difficult to use 10.50 9.66 10 189264 18795 110381230
Orthopnoea 10.49 9.66 42 189232 10979 110389046
Ureteric obstruction 10.48 9.66 19 189255 3095 110396930
Electrocardiogram T wave biphasic 10.48 9.66 6 189268 235 110399790
Electrocardiogram ST segment elevation 10.45 9.66 37 189237 9123 110390902
Neck pain 10.45 9.66 148 189126 122982 110277043
Hypoventilation 10.41 9.66 34 189240 8047 110391978
Nightmare 10.39 9.66 33 189241 38830 110361195
Injury 10.36 9.66 386 188888 176879 110223146
Eosinophilic pleural effusion 10.35 9.66 8 189266 520 110399505
Idiopathic pulmonary fibrosis 10.35 9.66 25 189249 4979 110395046
Right ventricular failure 10.34 9.66 78 189196 25876 110374149
Protein urine present 10.32 9.66 43 189231 11441 110388584
Cystitis haemorrhagic 10.28 9.66 4 189270 12205 110387820
Systemic viral infection 10.20 9.66 5 189269 142 110399883
Mouth ulceration 10.18 9.66 45 189229 48093 110351932
Cutaneous T-cell dyscrasia 10.15 9.66 4 189270 66 110399959
Dislocation of vertebra 10.13 9.66 117 189157 43604 110356421
Retinitis 10.12 9.66 92 189182 32235 110367790
Swelling face 10.10 9.66 105 189169 92216 110307809
Acute respiratory failure 10.08 9.66 183 189091 75077 110324948
Blood pressure systolic abnormal 10.08 9.66 75 189199 24775 110375250
Injection site inflammation 10.04 9.66 24 189250 4747 110395278
Chest discomfort 10.03 9.66 378 188896 173470 110226555
Acne 10.02 9.66 27 189247 33493 110366532
Heavy menstrual bleeding 9.99 9.66 8 189266 16357 110383668
Bacteraemia 9.98 9.66 38 189236 42352 110357673
Stupor 9.96 9.66 34 189240 8231 110391794
Oral herpes 9.96 9.66 100 189174 35980 110364045
Blood phosphorus increased 9.96 9.66 8 189266 16332 110383693
Acute myocardial infarction 9.95 9.66 200 189074 83577 110316448
Rectal fissure 9.94 9.66 11 189263 1133 110398892
BK virus infection 9.93 9.66 5 189269 13101 110386924
Dilatation atrial 9.92 9.66 21 189253 3831 110396194
Histoplasmosis 9.92 9.66 18 189256 2935 110397090
Peritoneal haematoma 9.89 9.66 6 189268 262 110399763
Fungal infection 9.85 9.66 49 189225 50757 110349268
Muscle twitching 9.82 9.66 23 189251 29912 110370113
Catheter site discharge 9.80 9.66 18 189256 2961 110397064
Paracentesis 9.73 9.66 12 189262 1388 110398637
Tetany 9.70 9.66 20 189254 3584 110396441
Haemorrhagic arteriovenous malformation 9.66 9.66 8 189266 574 110399451

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C05AE03 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Muscle relaxants
ATC C08DB01 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS
Benzothiazepine derivatives
FDA MoA N0000000069 Calcium Channel Antagonists
FDA EPC N0000175566 Calcium Channel Blocker
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014665 Vasodilator Agents
MeSH PA D049990 Membrane Transport Modulators
FDA MoA N0000182141 Cytochrome P450 3A4 Inhibitors
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35620 vasodilator agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:38215 calcium channel blocker
CHEBI has role CHEBI:50249 anticoagulant
CHEBI has role CHEBI:50503 laxative
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:53784 antispasmodic drug
CHEBI has role CHEBI:64946 anti-HIV agent

Related Drugs by ATC class:

C05AE Muscle relaxants 2 drugs
glyceryl trinitrateisosorbide dinitrate

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Atrial fibrillation indication 49436004 DOID:0060224
Paroxysmal supraventricular tachycardia indication 67198005
Prinzmetal angina indication 87343002
Angina pectoris indication 194828000
Anal fissure off-label use 30037006
Supraventricular arrhythmia off-label use 72654001
Diastolic heart failure off-label use 418304008 DOID:9775
Hyperkalemia contraindication 14140009
Ventricular tachycardia contraindication 25569003
Complete atrioventricular block contraindication 27885002
Acute cerebrovascular insufficiency contraindication 29322000
Sick sinus syndrome contraindication 36083008 DOID:13884
Immunosuppression contraindication 38013005
Angioedema contraindication 41291007 DOID:1558
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Lown-Ganong-Levine syndrome contraindication 55475008 DOID:13087
Aortic valve stenosis contraindication 60573004 DOID:1712
Wolff-Parkinson-White pattern contraindication 74390002 DOID:384
Transplantation contraindication 77465005
Chronic idiopathic constipation contraindication 82934008
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Disorder of connective tissue contraindication 105969002 DOID:65
Second degree atrioventricular block contraindication 195042002
Decompensated cardiac failure contraindication 195111005
Hypertrophic cardiomyopathy contraindication 233873004 DOID:11984
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Left ventricular cardiac dysfunction contraindication 429589006
Hemodialysis with High-Flux Membrane contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.63 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel BLOCKER IC50 7.32 WOMBAT-PK CHEMBL
Cytochrome P450 3A4 Enzyme IC50 5.74 DRUG MATRIX
Multidrug resistance protein 1 Transporter IC50 4.37 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 5.62 PDSP
5-hydroxytryptamine receptor 3A Ion channel BLOCKER IC50 4.68 IUPHAR
Voltage-dependent calcium channel gamma-1 subunit Ion channel IC50 6.10 WOMBAT-PK
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel Ki 4.02 WOMBAT-PK
Voltage-dependent L-type calcium channel subunit alpha-1S Ion channel Ki 6.42 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.91 CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 4.35 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 4.76 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel IC50 4.52 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel IC50 7.27 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1D Ion channel IC50 7.34 CHEMBL
5-hydroxytryptamine receptor 3A Ion channel BLOCKER IC50 5.26 IUPHAR
Voltage-gated L-type calcium channel Ion channel Ki 7.80 CHEMBL
Potassium voltage-gated channel subfamily C member 1 Ion channel BLOCKER IC50 4 IUPHAR
Potassium voltage-gated channel subfamily A member 7 Ion channel BLOCKER IC50 4.20 IUPHAR
Voltage-dependent L-type calcium channel subunit alpha-1F Ion channel BLOCKER IC50 4 IUPHAR

External reference:

IDSource
4020128 VUID
N0000179650 NUI
D00616 KEGG_DRUG
33286-22-5 SECONDARY_CAS_RN
203211 RXNORM
4018817 VANDF
4019722 VANDF
4020128 VANDF
CHEBI:101278 CHEBI
C9F PDB_CHEM_ID
CHEMBL23 ChEMBL_ID
CHEMBL1697 ChEMBL_ID
CHEMBL1200805 ChEMBL_ID
2298 IUPHAR_LIGAND_ID
144604-00-2 SECONDARY_CAS_RN
DB00343 DRUGBANK_ID
EE92BBP03H UNII
1547 MMSL
4604 MMSL
d00045 MMSL
000711 NDDF
004514 NDDF
007237 NDDF
12218006 SNOMEDCT_US
372793000 SNOMEDCT_US
59941008 SNOMEDCT_US
C0012373 UMLSCUI
D004110 MESH_DESCRIPTOR_UI
3433 INN_ID
39186 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Diltiazem Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0318 TABLET, FILM COATED 30 mg ORAL ANDA 18 sections
Diltiazem Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0319 TABLET, FILM COATED 60 mg ORAL ANDA 18 sections
Diltiazem Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0320 TABLET, FILM COATED 90 mg ORAL ANDA 18 sections
Diltiazem Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0321 TABLET, FILM COATED 120 mg ORAL ANDA 18 sections
Cardizem HUMAN PRESCRIPTION DRUG LABEL 1 0187-0771 TABLET, COATED 30 mg ORAL NDA 22 sections
Cardizem HUMAN PRESCRIPTION DRUG LABEL 1 0187-0772 TABLET, COATED 60 mg ORAL NDA 22 sections
Cardizem HUMAN PRESCRIPTION DRUG LABEL 1 0187-0791 TABLET, COATED 90 mg ORAL NDA 22 sections
Cardizem HUMAN PRESCRIPTION DRUG LABEL 1 0187-0792 TABLET, COATED 120 mg ORAL NDA 22 sections
Cardizem CD HUMAN PRESCRIPTION DRUG LABEL 1 0187-0795 CAPSULE, COATED, EXTENDED RELEASE 120 mg ORAL NDA 15 sections
Cardizem CD HUMAN PRESCRIPTION DRUG LABEL 1 0187-0796 CAPSULE, COATED, EXTENDED RELEASE 180 mg ORAL NDA 15 sections
Cardizem CD HUMAN PRESCRIPTION DRUG LABEL 1 0187-0797 CAPSULE, COATED, EXTENDED RELEASE 240 mg ORAL NDA 15 sections
Cardizem CD HUMAN PRESCRIPTION DRUG LABEL 1 0187-0798 CAPSULE, COATED, EXTENDED RELEASE 300 mg ORAL NDA 15 sections
Cardizem CD HUMAN PRESCRIPTION DRUG LABEL 1 0187-0799 CAPSULE, COATED, EXTENDED RELEASE 360 mg ORAL NDA 15 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2045 TABLET, EXTENDED RELEASE 120 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2045 TABLET, EXTENDED RELEASE 120 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2046 TABLET, EXTENDED RELEASE 180 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2046 TABLET, EXTENDED RELEASE 180 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2047 TABLET, EXTENDED RELEASE 240 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2047 TABLET, EXTENDED RELEASE 240 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2048 TABLET, EXTENDED RELEASE 300 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2048 TABLET, EXTENDED RELEASE 300 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2049 TABLET, EXTENDED RELEASE 360 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2049 TABLET, EXTENDED RELEASE 360 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2050 TABLET, EXTENDED RELEASE 420 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2050 TABLET, EXTENDED RELEASE 420 mg ORAL NDA 25 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2612 CAPSULE, EXTENDED RELEASE 120 mg ORAL NDA 23 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2613 CAPSULE, EXTENDED RELEASE 180 mg ORAL NDA 23 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2614 CAPSULE, EXTENDED RELEASE 240 mg ORAL NDA 23 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2615 CAPSULE, EXTENDED RELEASE 300 mg ORAL NDA 23 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2616 CAPSULE, EXTENDED RELEASE 360 mg ORAL NDA 23 sections