diltiazem ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, diltiazem derivatives 897 42399-41-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • (+)-Diltiazem
  • dilzem
  • d-Diltiazem
  • d-cis-Diltiazem
  • diltiazem hydrochloride
  • diltiazem malate
  • diltiazem
  • diltiazem HCl
A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
  • Molecular weight: 414.52
  • Formula: C22H26N2O4S
  • CLOGP: 3.65
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 59.08
  • ALOGS: -4.39
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.24 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 19.30 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 38 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 13 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.18 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 5, 1982 FDA VALEANT INTL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Atrial fibrillation 541.41 10.10 784 90271 100961 50413108
Completed suicide 414.92 10.10 803 90252 131086 50382983
Sedation complication 402.38 10.10 230 90825 8536 50505533
Creatinine renal clearance decreased 391.37 10.10 252 90803 11629 50502440
Orthostatic hypotension 350.74 10.10 343 90712 29138 50484931
Hypotension 314.28 10.10 1034 90021 234435 50279634
Cardiac failure congestive 273.97 10.10 521 90534 83861 50430208
Sedation 257.16 10.10 296 90759 30314 50483755
Blood calcium decreased 255.82 10.10 246 90809 20460 50493609
Maternal exposure during pregnancy 220.02 10.10 18 91037 159760 50354309
Cognitive disorder 218.46 10.10 329 90726 43794 50470275
Balance disorder 214.60 10.10 424 90631 70166 50443903
Drug ineffective 206.88 10.10 770 90285 818563 49695506
Toxicity to various agents 186.74 10.10 817 90238 211682 50302387
Pemphigus 185.45 10.10 7 91048 120159 50393910
Bradycardia 183.90 10.10 377 90678 64049 50450020
Depressed level of consciousness 183.84 10.10 333 90722 51620 50462449
Off label use 164.10 10.10 384 90671 474042 50040027
Synovitis 152.49 10.10 21 91034 123844 50390225
Fall 145.81 10.10 1066 89989 333866 50180203
Hand deformity 144.48 10.10 9 91046 100190 50413879
Nerve injury 144.42 10.10 120 90935 8230 50505839
Treatment failure 134.97 10.10 40 91015 137597 50376472
Exposure during pregnancy 132.51 10.10 28 91027 120987 50393082
Systemic lupus erythematosus 132.30 10.10 44 91011 140578 50373491
Dyspnoea 131.60 10.10 1533 89522 546075 49967994
Glossodynia 121.99 10.10 29 91026 115540 50398529
Drug intolerance 114.93 10.10 135 90920 218969 50295100
Rheumatoid arthritis 113.72 10.10 118 90937 202432 50311637
Therapeutic product effect decreased 110.90 10.10 53 91002 135997 50378072
Dyspnoea exertional 110.36 10.10 268 90787 50965 50463104
Alopecia 106.46 10.10 173 90882 244874 50269195
Pulmonary congestion 101.30 10.10 131 90924 15116 50498953
Arthropathy 99.21 10.10 83 90972 157823 50356246
Neutropenia 98.99 10.10 73 90982 147892 50366177
Hepatic enzyme increased 96.89 10.10 64 90991 137316 50376753
Product use issue 93.37 10.10 79 90976 149396 50364673
Heart rate increased 91.94 10.10 327 90728 76923 50437146
Discomfort 91.78 10.10 40 91015 108340 50405729
Joint swelling 91.56 10.10 190 90865 245096 50268973
Fluid retention 91.54 10.10 248 90807 50401 50463668
Pericarditis 90.79 10.10 16 91039 78673 50435396
Contraindicated product administered 87.92 10.10 83 90972 148875 50365194
Wound 85.01 10.10 42 91013 105752 50408317
Infusion related reaction 84.11 10.10 109 90946 169448 50344621
Nephrolithiasis 81.78 10.10 188 90867 34505 50479564
Febrile neutropenia 78.13 10.10 39 91016 97628 50416441
Constipation 76.55 10.10 584 90471 185124 50328945
Pulmonary arterial hypertension 75.37 10.10 133 90922 20186 50493883
Chest pain 71.09 10.10 553 90502 176329 50337740
Atrioventricular block second degree 71.00 10.10 56 90999 3565 50510504
Labile blood pressure 69.39 10.10 41 91014 1619 50512450
Rash 69.26 10.10 482 90573 436989 50077080
Gastrointestinal haemorrhage 68.12 10.10 287 90768 73034 50441035
Bunion operation 66.44 10.10 35 91020 1102 50512967
Respiratory tract congestion 66.18 10.10 103 90952 14096 50499973
Suspected suicide 64.93 10.10 63 90992 5294 50508775
Systemic lupus erythematosus rash 64.73 10.10 40 91015 1715 50512354
Chronic obstructive pulmonary disease 64.25 10.10 227 90828 53208 50460861
Pneumonia 59.37 10.10 983 90072 377418 50136651
Atrioventricular block complete 58.96 10.10 69 90986 7186 50506883
Mobility decreased 58.70 10.10 292 90763 79656 50434413
Body tinea 56.06 10.10 33 91022 1294 50512775
Inhibitory drug interaction 53.66 10.10 39 91016 2194 50511875
Musculoskeletal stiffness 52.69 10.10 94 90961 128387 50385682
Malignant neoplasm progression 51.82 10.10 29 91026 68095 50445974
Therapeutic product effect incomplete 51.65 10.10 53 91002 91462 50422607
Abortion spontaneous 51.57 10.10 7 91048 41765 50472304
Cardiogenic shock 51.38 10.10 97 90958 15502 50498567
Atrial flutter 48.64 10.10 69 90986 8694 50505375
Oedema peripheral 47.82 10.10 464 90591 157497 50356572
Leukopenia 46.85 10.10 32 91023 67496 50446573
Abdominal discomfort 46.18 10.10 237 90818 231404 50282665
General physical health deterioration 46.10 10.10 119 90936 142315 50371754
Nodal rhythm 45.79 10.10 31 91024 1556 50512513
Death 45.13 10.10 829 90226 324550 50189519
Alveolitis 45.03 10.10 37 91018 2497 50511572
Asthma 44.35 10.10 294 90761 89043 50425026
Helicobacter infection 44.24 10.10 17 91038 49685 50464384
Coronary artery disease 43.51 10.10 135 90920 29591 50484478
Folliculitis 43.06 10.10 9 91046 39216 50474853
Injection site erythema 42.74 10.10 43 91012 74893 50439176
Pain in jaw 41.76 10.10 158 90897 38270 50475799
Dizziness 41.45 10.10 863 90192 345506 50168563
Hypoxia 41.33 10.10 192 90863 50931 50463138
Palpitations 41.02 10.10 301 90754 94205 50419864
Hunger 40.54 10.10 44 91011 4219 50509850
Product use in unapproved indication 40.43 10.10 93 90962 115726 50398343
Renal failure 40.39 10.10 329 90726 106304 50407765
Stomatitis 39.90 10.10 76 90979 101268 50412801
Cardiac disorder 39.72 10.10 168 90887 42811 50471258
Hepatic ischaemia 39.31 10.10 20 91035 585 50513484
Pregnancy 38.88 10.10 4 91051 29573 50484496
Pericardial haemorrhage 38.57 10.10 27 91028 1431 50512638
Pulmonary hypertension 38.49 10.10 140 90915 33277 50480792
Atrioventricular block first degree 37.67 10.10 51 91004 6150 50507919
Vasoplegia syndrome 37.59 10.10 24 91031 1090 50512979
Thrombocytopenia 36.63 10.10 113 90942 127560 50386509
Infection susceptibility increased 36.33 10.10 33 91022 2551 50511518
Bezoar 35.75 10.10 25 91030 1323 50512746
Arthralgia 35.71 10.10 565 90490 438137 50075932
Angina pectoris 35.65 10.10 116 90939 26072 50487997
Heart rate decreased 35.56 10.10 145 90910 36352 50477717
Limb injury 35.42 10.10 98 90957 20152 50493917
Pyrexia 34.98 10.10 478 90577 379725 50134344
Myocardial infarction 33.88 10.10 275 90780 88752 50425317
Cough 33.51 10.10 615 90440 240649 50273420
Bronchitis 33.50 10.10 310 90745 103849 50410220
Hospitalisation 33.36 10.10 223 90832 67714 50446355
Blister 32.80 10.10 65 90990 85353 50428716
Ill-defined disorder 32.75 10.10 30 91025 54624 50459445
Foot deformity 32.65 10.10 92 90963 19118 50494951
Muscle injury 32.52 10.10 13 91042 37098 50476971
Urinary tract discomfort 31.96 10.10 13 91042 222 50513847
Muscle relaxant therapy 31.94 10.10 12 91043 164 50513905
Oedema 31.88 10.10 226 90829 69955 50444114
Cardiac arrest 31.61 10.10 258 90797 83393 50430676
White blood cell count decreased 31.60 10.10 106 90949 116616 50397453
Transfusion 31.59 10.10 71 90984 12834 50501235
Intentional product use issue 30.87 10.10 57 90998 76861 50437208
Asthenia 30.68 10.10 771 90284 318271 50195798
Impaired quality of life 29.72 10.10 45 91010 6011 50508058
BRASH syndrome 29.71 10.10 12 91043 201 50513868
Forced expiratory volume decreased 29.57 10.10 38 91017 4356 50509713
Hypervolaemia 29.51 10.10 107 90948 25392 50488677
Blood pressure systolic increased 29.28 10.10 134 90921 35315 50478754
Pancytopenia 28.90 10.10 68 90987 83962 50430107
Atrioventricular block 28.81 10.10 46 91009 6432 50507637
Full blood count abnormal 28.66 10.10 100 90955 23288 50490781
Pulseless electrical activity 28.29 10.10 47 91008 6794 50507275
Intentional self-injury 28.23 10.10 4 91051 23108 50490961
Productive cough 27.72 10.10 176 90879 52518 50461551
Erythromelalgia 27.71 10.10 10 91045 121 50513948
Gastrointestinal disorder 27.51 10.10 83 90972 94373 50419696
Heart sounds 27.49 10.10 16 91039 614 50513455
Rales 26.81 10.10 57 90998 9921 50504148
Alveolar osteitis 26.80 10.10 14 91041 433 50513636
Neutrophil count decreased 26.71 10.10 26 91029 46000 50468069
Poor quality sleep 26.62 10.10 78 90977 16568 50497501
Mucosal inflammation 26.56 10.10 20 91035 40122 50473947
Arteriovenous fistula occlusion 26.00 10.10 13 91042 366 50513703
Sleep disorder due to general medical condition, insomnia type 25.99 10.10 12 91043 31435 50482634
Hepatorenal syndrome 25.97 10.10 23 91032 1720 50512349
Cardiac failure 25.81 10.10 229 90826 75811 50438258
Weight decreased 25.68 10.10 549 90506 220696 50293373
Unevaluable event 25.57 10.10 156 90899 45910 50468159
Hyperkalaemia 25.53 10.10 161 90894 47928 50466141
Gouty tophus 25.53 10.10 10 91045 154 50513915
Prolonged expiration 25.50 10.10 16 91039 705 50513364
Cardiac pacemaker insertion 25.23 10.10 32 91023 3621 50510448
Blue toe syndrome 25.16 10.10 13 91042 393 50513676
Bladder prolapse 25.10 10.10 23 91032 1798 50512271
Glucose tolerance impaired 25.08 10.10 38 91017 5080 50508989
Condition aggravated 24.99 10.10 380 90675 296678 50217391
Foetal exposure during pregnancy 24.94 10.10 9 91046 27350 50486719
Cerebrovascular accident 24.75 10.10 270 90785 94410 50419659
Kidney infection 24.59 10.10 82 90973 18664 50495405
Device pacing issue 24.39 10.10 8 91047 71 50513998
C-reactive protein increased 24.32 10.10 52 91003 66422 50447647
Erythrodermic psoriasis 24.24 10.10 17 91038 904 50513165
Suicidal ideation 24.09 10.10 39 91016 55346 50458723
Nasal congestion 24.02 10.10 166 90889 50954 50463115
Coagulopathy 23.99 10.10 79 90976 17865 50496204
Nephroangiosclerosis 23.56 10.10 9 91046 129 50513940
Irritable bowel syndrome 23.54 10.10 35 91020 51406 50462663
Myopathy 23.18 10.10 51 91004 9088 50504981
Blood iron decreased 23.14 10.10 59 90996 11556 50502513
Oxygen saturation decreased 22.54 10.10 216 90839 73032 50441037
Heart rate irregular 22.20 10.10 81 90974 19279 50494790
Stent placement 21.99 10.10 29 91026 3409 50510660
Pulmonary oedema 21.87 10.10 157 90898 48781 50465288
Red blood cell sedimentation rate increased 21.69 10.10 13 91042 29403 50484666
Drug resistance 21.59 10.10 4 91051 18985 50495084
Torsade de pointes 21.42 10.10 58 90997 11777 50502292
Premature delivery 21.21 10.10 8 91047 23655 50490414
Cardiac ablation 21.14 10.10 18 91037 1276 50512793
Tunnel vision 20.64 10.10 14 91041 705 50513364
Supraventricular tachycardia 20.49 10.10 60 90995 12741 50501328
Paranasal sinus discomfort 20.37 10.10 26 91029 2960 50511109
Rectal prolapse 20.13 10.10 20 91035 1729 50512340
Hepatotoxicity 20.12 10.10 12 91043 27214 50486855
Blood pressure increased 20.10 10.10 344 90711 132788 50381281
Seizure 20.00 10.10 127 90928 117747 50396322
Peak expiratory flow rate abnormal 20.00 10.10 7 91048 77 50513992
Disease progression 19.69 10.10 97 90958 95769 50418300
Liver injury 19.68 10.10 10 91045 24796 50489273
Injection site pain 19.68 10.10 118 90937 110906 50403163
Live birth 19.67 10.10 3 91052 16405 50497664
Swelling 19.35 10.10 250 90805 200622 50313447
Feeling cold 19.34 10.10 78 90977 19453 50494616
Syncope 19.29 10.10 276 90779 102726 50411343
Bone marrow failure 19.28 10.10 13 91042 27611 50486458
Medication error 19.24 10.10 121 90934 35983 50478086
Bladder pain 19.10 10.10 19 91036 1645 50512424
International normalised ratio increased 19.03 10.10 138 90917 43014 50471055
Injection site pruritus 18.98 10.10 27 91028 40384 50473685
Presyncope 18.90 10.10 90 90965 24108 50489961
Cardioversion 18.86 10.10 16 91039 1129 50512940
Knee arthroplasty 18.85 10.10 22 91033 35824 50478245
Confusional state 18.80 10.10 229 90826 185699 50328370
Product complaint 18.60 10.10 54 91001 11412 50502657
Premature baby 18.56 10.10 5 91050 18332 50495737
Colon gangrene 18.52 10.10 4 91051 4 50514065
Alanine aminotransferase increased 18.38 10.10 89 90966 88270 50425799
Thermal burn 18.35 10.10 32 91023 4809 50509260
Ventricular arrhythmia 18.28 10.10 26 91029 3283 50510786
Blood pressure diastolic decreased 18.23 10.10 69 90986 16712 50497357
Occult blood 18.13 10.10 16 91039 1191 50512878
Stupor 18.12 10.10 27 91028 3556 50510513
Cellulitis 18.09 10.10 201 90854 70597 50443472
Urticaria 17.92 10.10 148 90907 129413 50384656
Tooth infection 17.86 10.10 61 90994 14051 50500018
Oxygen therapy 17.75 10.10 19 91036 1793 50512276
Gastrooesophageal reflux disease 17.74 10.10 213 90842 76215 50437854
Disturbance in attention 17.66 10.10 18 91037 31168 50482901
Sinus bradycardia 17.59 10.10 58 90997 13125 50500944
Wound complication 17.29 10.10 23 91032 2727 50511342
Aortic arteriosclerosis 17.15 10.10 33 91022 5349 50508720
Carbon dioxide increased 17.02 10.10 15 91040 1114 50512955
Lower gastrointestinal haemorrhage 17.01 10.10 38 91017 6841 50507228
Myocardial hypoxia 16.91 10.10 4 91051 8 50514061
Humidity intolerance 16.84 10.10 9 91046 292 50513777
Cerebellar syndrome 16.82 10.10 25 91030 3286 50510783
Product residue present 16.23 10.10 26 91029 3646 50510423
Night sweats 16.20 10.10 22 91033 33552 50480517
Acute lung injury 16.17 10.10 16 91039 1377 50512692
Renal pain 16.15 10.10 33 91022 5586 50508483
Skin laceration 16.14 10.10 72 90983 18770 50495299
Electrocardiogram QRS complex prolonged 16.09 10.10 32 91023 5312 50508757
Catheter site erythema 16.09 10.10 27 91028 3935 50510134
Respiratory rate increased 16.01 10.10 51 91004 11334 50502735
Aspartate aminotransferase increased 15.97 10.10 79 90976 77919 50436150
Unresponsive to stimuli 15.95 10.10 102 90953 30507 50483562
Obstructive airways disorder 15.89 10.10 63 90992 15589 50498480
Hyperlipidaemia 15.87 10.10 68 90987 17422 50496647
Drug abuse 15.75 10.10 55 91000 59791 50454278
Coronary artery bypass 15.70 10.10 20 91035 2273 50511796
Electrocardiogram U wave present 15.65 10.10 6 91049 87 50513982
Animal scratch 15.61 10.10 13 91042 894 50513175
Anion gap abnormal 15.59 10.10 9 91046 340 50513729
Ventricular tachycardia 15.52 10.10 63 90992 15758 50498311
Malaise 15.27 10.10 744 90311 334788 50179281
Posterior reversible encephalopathy syndrome 15.25 10.10 4 91051 14924 50499145
Sinoatrial block 15.22 10.10 12 91043 763 50513306
Nodal arrhythmia 15.11 10.10 14 91041 1110 50512959
Drug interaction 15.10 10.10 468 90587 199153 50314916
Incision site haemorrhage 15.08 10.10 10 91045 485 50513584
Pain in extremity 15.03 10.10 617 90438 272248 50241821
Drug-induced liver injury 15.03 10.10 17 91038 28078 50485991
Injection site swelling 15.01 10.10 33 91022 41740 50472329
Polymyalgia rheumatica 14.99 10.10 21 91034 2615 50511454
Status epilepticus 14.87 10.10 3 91052 13403 50500666
Seasonal allergy 14.84 10.10 59 90996 14617 50499452
Sleep disorder 14.83 10.10 53 91002 57230 50456839
Leukaemoid reaction 14.73 10.10 7 91048 176 50513893
Respiration abnormal 14.71 10.10 30 91025 5072 50508997
Gravitational oedema 14.68 10.10 14 91041 1151 50512918
Anaphylactic reaction 14.68 10.10 49 91006 54006 50460063
Hip arthroplasty 14.62 10.10 20 91035 30409 50483660
Drug hypersensitivity 14.61 10.10 342 90713 250668 50263401
Cardiac monitoring 14.50 10.10 4 91051 18 50514051
Purpura 14.49 10.10 45 91010 9866 50504203
Cardiac valve disease 14.32 10.10 25 91030 3761 50510308
Sebaceous gland infection 14.31 10.10 6 91049 111 50513958
Pollakiuria 14.02 10.10 82 90973 23769 50490300
Infusion site warmth 13.98 10.10 15 91040 1419 50512650
Catheter site haemorrhage 13.96 10.10 21 91034 2789 50511280
Catheter site discharge 13.92 10.10 17 91038 1851 50512218
Blood loss anaemia 13.85 10.10 39 91016 8100 50505969
Arrhythmogenic right ventricular dysplasia 13.84 10.10 4 91051 22 50514047
Chronic respiratory failure 13.83 10.10 16 91039 1646 50512423
Electrocardiogram QT shortened 13.75 10.10 6 91049 123 50513946
Orthopnoea 13.59 10.10 31 91024 5658 50508411
Chondrocalcinosis 13.51 10.10 10 91045 579 50513490
Respiratory acidosis 13.47 10.10 32 91023 5996 50508073
Oral herpes 13.33 10.10 73 90982 20652 50493417
Atrioventricular dissociation 13.33 10.10 7 91048 219 50513850
Fibrous histiocytoma 13.32 10.10 9 91046 450 50513619
Metastases to liver 13.32 10.10 10 91045 20094 50493975
Injection site inflammation 13.23 10.10 22 91033 3183 50510886
Cytomegalovirus infection 13.15 10.10 8 91047 17954 50496115
Cardioactive drug level increased 13.10 10.10 17 91038 1967 50512102
Histoplasmosis 13.09 10.10 16 91039 1743 50512326
Anal abscess 13.02 10.10 24 91031 3767 50510302
Blood pressure inadequately controlled 12.92 10.10 26 91029 4354 50509715
Liver disorder 12.89 10.10 30 91025 37192 50476877
Depression 12.75 10.10 215 90840 165208 50348861
Chest discomfort 12.71 10.10 236 90819 92486 50421583
Pruritus 12.70 10.10 401 90654 283167 50230902
Bladder disorder 12.69 10.10 36 91019 7507 50506562
Inflammation 12.62 10.10 56 90999 56856 50457213
Bronchopulmonary aspergillosis allergic 12.58 10.10 13 91042 1178 50512891
Aortic stenosis 12.49 10.10 25 91030 4169 50509900
Product commingling 12.47 10.10 6 91049 155 50513914
Arrhythmia 12.41 10.10 102 90953 33030 50481039
Sinusitis 12.40 10.10 224 90831 170334 50343735
Pulmonary embolism 12.38 10.10 120 90935 101584 50412485
Mastication disorder 12.38 10.10 16 91039 1844 50512225
Distributive shock 12.35 10.10 11 91044 829 50513240
Multiple sclerosis relapse 12.33 10.10 38 91017 42926 50471143
Neutropenic sepsis 12.32 10.10 5 91050 14142 50499927
Sinus node dysfunction 12.29 10.10 24 91031 3931 50510138
Infusion site erythema 12.19 10.10 39 91016 8688 50505381
Aggression 12.17 10.10 12 91043 21104 50492965
Catheter site inflammation 12.14 10.10 10 91045 677 50513392
Muscle spasticity 12.11 10.10 8 91047 17176 50496893
Haemarthrosis 12.05 10.10 20 91035 2888 50511181
Infusion site pain 11.98 10.10 49 91006 12297 50501772
Premature labour 11.86 10.10 3 91052 11473 50502596
Metastases to bone 11.86 10.10 9 91046 17986 50496083
Coronary artery occlusion 11.85 10.10 35 91020 7468 50506601
Sopor 11.80 10.10 11 91044 19868 50494201
Bronchiectasis 11.77 10.10 43 91012 10240 50503829
Bundle branch block left 11.75 10.10 31 91024 6199 50507870
Total lung capacity decreased 11.71 10.10 13 91042 1278 50512791
Joint stiffness 11.68 10.10 23 91032 30285 50483784
Oxygen consumption increased 11.66 10.10 22 91033 3514 50510555
Acute generalised exanthematous pustulosis 11.63 10.10 39 91016 8899 50505170
Metastases to central nervous system 11.57 10.10 3 91052 11279 50502790
Abnormal behaviour 11.53 10.10 11 91044 19647 50494422
Wrong technique in product usage process 11.49 10.10 56 90999 55454 50458615
Ear congestion 11.45 10.10 16 91039 1987 50512082
Agranulocytosis 11.42 10.10 13 91042 21408 50492661
Caesarean section 11.40 10.10 7 91048 15632 50498437
Duodenal polyp 11.35 10.10 5 91050 105 50513964
Infusion site infection 11.34 10.10 14 91041 1541 50512528
Intervertebral disc space narrowing 11.32 10.10 11 91044 926 50513143
Haematemesis 11.28 10.10 87 90968 27638 50486431
Angina unstable 11.28 10.10 32 91023 6674 50507395
Lower respiratory tract congestion 11.25 10.10 16 91039 2020 50512049
Accidental exposure to product 11.23 10.10 15 91040 23042 50491027
Vitamin D decreased 11.23 10.10 37 91018 8369 50505700
Psoriatic arthropathy 11.21 10.10 45 91010 46987 50467082
Aspiration pleural cavity 11.21 10.10 10 91045 755 50513314
Hypovolaemia 11.19 10.10 40 91015 9425 50504644
Nasal polyps 11.17 10.10 18 91037 2536 50511533
Injection site urticaria 11.17 10.10 4 91051 12213 50501856
Spondyloarthropathy 11.13 10.10 10 91045 762 50513307
Blood pressure systolic 11.04 10.10 4 91051 49 50514020
Gamma-glutamyltransferase increased 10.98 10.10 23 91032 29600 50484469
Atrial appendage closure 10.97 10.10 3 91052 13 50514056
Heart rate abnormal 10.95 10.10 23 91032 3969 50510100
Inappropriate schedule of product administration 10.89 10.10 80 90975 71751 50442318
Brain hypoxia 10.88 10.10 8 91047 458 50513611
Infusion site discharge 10.83 10.10 9 91046 617 50513452
Fatigue 10.81 10.10 1112 89943 706489 49807580
Catheterisation cardiac 10.76 10.10 23 91032 4017 50510052
Acute myeloid leukaemia 10.64 10.10 7 91048 15067 50499002
Cataract 10.62 10.10 131 90924 47169 50466900
Nodule 10.58 10.10 9 91046 16994 50497075
Rectal haemorrhage 10.55 10.10 111 90944 38447 50475622
Epilepsy 10.54 10.10 14 91041 21553 50492516
Atrial pressure increased 10.46 10.10 3 91052 16 50514053
Renal necrosis 10.43 10.10 4 91051 58 50514011
Bone disorder 10.42 10.10 11 91044 18741 50495328
Hypochromic anaemia 10.38 10.10 14 91041 1682 50512387
Abdominal rigidity 10.33 10.10 14 91041 1690 50512379
Catheter management 10.25 10.10 18 91037 2721 50511348
Reperfusion arrhythmia 10.24 10.10 6 91049 233 50513836
Circadian rhythm sleep disorder 10.22 10.10 6 91049 234 50513835
Wound necrosis 10.20 10.10 7 91048 359 50513710
Ectopic ACTH syndrome 10.19 10.10 5 91050 135 50513934
Enterococcal sepsis 10.15 10.10 12 91043 1263 50512806

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Atrial fibrillation 234.85 10.77 527 47833 105119 29421048
Completed suicide 213.86 10.77 462 47898 89784 29436383
Bradycardia 195.99 10.77 370 47990 65259 29460908
Cardiac failure congestive 143.84 10.77 358 48002 76223 29449944
Off label use 99.74 10.77 215 48145 300585 29225582
Hypotension 91.74 10.77 587 47773 193767 29332400
Dyspnoea 84.77 10.77 860 47500 325872 29200295
Febrile neutropenia 60.05 10.77 57 48303 112183 29413984
Myocardial infarction 59.41 10.77 345 48015 109951 29416216
Chronic obstructive pulmonary disease 52.67 10.77 167 48193 40788 29485379
BRASH syndrome 50.38 10.77 16 48344 141 29526026
Cardiac arrest 50.21 10.77 274 48086 85317 29440850
Suspected suicide 48.15 10.77 45 48315 3975 29522192
Incision site pain 47.59 10.77 32 48328 1751 29524416
Drug ineffective 45.13 10.77 379 47981 362791 29163376
Neutropenia 42.77 10.77 95 48265 131616 29394551
Conjunctivitis allergic 42.72 10.77 21 48339 629 29525538
Mycotic allergy 42.24 10.77 16 48344 248 29525919
Atrial flutter 40.96 10.77 78 48282 13816 29512351
Mite allergy 39.40 10.77 16 48344 301 29525866
Atrioventricular block complete 38.47 10.77 56 48304 7955 29518212
Cardiogenic shock 37.31 10.77 91 48269 19099 29507068
Atrioventricular block 36.77 10.77 51 48309 6931 29519236
Spirometry abnormal 36.72 10.77 16 48344 361 29525806
Pyrexia 36.65 10.77 298 48062 287324 29238843
Foetal exposure during pregnancy 36.07 10.77 6 48354 33861 29492306
Fluid retention 35.88 10.77 102 48258 23458 29502709
Dizziness 35.77 10.77 470 47890 189214 29336953
Pulmonary arterial hypertension 35.67 10.77 52 48308 7397 29518770
General physical health deterioration 35.20 10.77 72 48288 102785 29423382
Coronary artery disease 33.36 10.77 152 48208 44038 29482129
Dust allergy 32.74 10.77 16 48344 473 29525694
Cardioplegia 32.51 10.77 6 48354 0 29526167
Drug interaction 31.54 10.77 475 47885 196910 29329257
Red blood cells urine positive 28.71 10.77 23 48337 1650 29524517
Atrioventricular block first degree 28.23 10.77 39 48321 5280 29520887
Tetany 28.18 10.77 16 48344 646 29525521
Arterial spasm 27.24 10.77 9 48351 91 29526076
Product use in unapproved indication 27.09 10.77 64 48296 86811 29439356
Antiacetylcholine receptor antibody positive 27.05 10.77 8 48352 54 29526113
Oedema peripheral 26.83 10.77 273 48087 103284 29422883
Pacemaker generated rhythm 26.09 10.77 8 48352 62 29526105
Syncope 24.27 10.77 221 48139 81150 29445017
Chest pain 23.87 10.77 284 48076 111689 29414478
Cerebrovascular accident 22.99 10.77 209 48151 76702 29449465
Gastrointestinal haemorrhage 22.71 10.77 214 48146 79319 29446848
Productive cough 22.46 10.77 106 48254 31153 29495014
Pancytopenia 22.33 10.77 66 48294 83102 29443065
Prinzmetal angina 21.93 10.77 15 48345 844 29525323
Thrombocytopenia 21.88 10.77 130 48230 134693 29391474
Angina unstable 21.62 10.77 52 48308 10813 29515354
Atrial thrombosis 21.39 10.77 21 48339 1972 29524195
Neutrophil count decreased 21.15 10.77 24 48336 43543 29482624
Chondrocalcinosis 20.77 10.77 10 48350 286 29525881
Influenza virus test positive 20.74 10.77 7 48353 76 29526091
Hypoxia 20.35 10.77 140 48220 47239 29478928
Protein urine present 19.96 10.77 31 48329 4663 29521504
Acquired haemophilia 19.83 10.77 14 48346 829 29525338
Cardiac disorder 19.65 10.77 116 48244 37147 29489020
Procedural pain 19.42 10.77 29 48331 4215 29521952
Toxic optic neuropathy 19.06 10.77 13 48347 728 29525439
Lymphocyte count decreased 19.02 10.77 72 48288 19199 29506968
Angina pectoris 18.97 10.77 93 48267 27757 29498410
Gallbladder polyp 18.91 10.77 10 48350 350 29525817
Discharge 18.59 10.77 8 48352 175 29525992
Urinary tract discomfort 18.45 10.77 7 48353 109 29526058
Medication error 18.32 10.77 76 48284 21135 29505032
Rectal fissure 17.91 10.77 9 48351 283 29525884
Eczema infected 17.85 10.77 5 48355 27 29526140
International normalised ratio increased 17.82 10.77 129 48231 44243 29481924
Palpitations 17.51 10.77 102 48258 32502 29493665
Hepatic function abnormal 16.60 10.77 24 48336 39235 29486932
Heart rate irregular 16.40 10.77 53 48307 13064 29513103
Nodal arrhythmia 16.23 10.77 12 48348 764 29525403
Oxygen saturation decreased 16 10.77 127 48233 44810 29481357
Distributive shock 15.76 10.77 13 48347 972 29525195
Pneumocystis jirovecii pneumonia 15.74 10.77 4 48356 16775 29509392
Tooth injury 15.51 10.77 12 48348 818 29525349
Device dislocation 15.35 10.77 27 48333 4500 29521667
Product use issue 15.16 10.77 39 48321 51405 29474762
Malignant neoplasm progression 14.92 10.77 66 48294 73793 29452374
White blood cell count decreased 14.81 10.77 78 48282 83284 29442883
Angina bullosa haemorrhagica 14.67 10.77 5 48355 56 29526111
Premature baby 14.60 10.77 5 48355 17275 29508892
Septic shock 14.47 10.77 53 48307 62507 29463660
Eosinophilic pleural effusion 14.42 10.77 7 48353 204 29525963
Arteriosclerosis coronary artery 14.32 10.77 44 48316 10561 29515606
Mast cell degranulation present 14.14 10.77 5 48355 63 29526104
Vitiligo 14.03 10.77 11 48349 765 29525402
Perineal pain 13.95 10.77 11 48349 771 29525396
Hypervolaemia 13.72 10.77 61 48299 17484 29508683
Mucosal inflammation 13.67 10.77 19 48341 31576 29494591
Wheezing 13.56 10.77 97 48263 33143 29493024
Heart rate decreased 13.42 10.77 78 48282 24834 29501333
Pericardial haemorrhage 13.37 10.77 20 48340 2911 29523256
Labyrinthitis 13.35 10.77 11 48349 821 29525346
Ventricular fibrillation 13.10 10.77 56 48304 15777 29510390
Neuroleptic malignant syndrome 13.09 10.77 5 48355 16143 29510024
Subacute cutaneous lupus erythematosus 13.05 10.77 11 48349 848 29525319
Lower gastrointestinal haemorrhage 12.93 10.77 36 48324 8177 29517990
Aortic stenosis 12.91 10.77 23 48337 3871 29522296
Aggression 12.90 10.77 24 48336 35517 29490650
Peripheral swelling 12.84 10.77 160 48200 63579 29462588
Brugada syndrome 12.81 10.77 10 48350 691 29525476
Blood urine present 12.73 10.77 40 48320 9715 29516452
Alveolar osteitis 12.67 10.77 5 48355 87 29526080
Sepsis 12.64 10.77 161 48199 142521 29383646
Drug resistance 12.64 10.77 10 48350 21530 29504637
Nodal rhythm 12.50 10.77 13 48347 1307 29524860
Ischaemic hepatitis 12.48 10.77 14 48346 1534 29524633
Full blood count abnormal 12.35 10.77 53 48307 14960 29511207
Anticoagulation drug level above therapeutic 12.17 10.77 15 48345 1816 29524351
Injury 11.84 10.77 62 48298 18984 29507183
Inner ear disorder 11.81 10.77 6 48354 193 29525974
Heart rate increased 11.72 10.77 106 48254 38832 29487335
Ear congestion 11.53 10.77 8 48352 461 29525706
Bronchopulmonary aspergillosis 11.47 10.77 3 48357 12341 29513826
Arrhythmia 11.42 10.77 89 48271 31224 29494943
Bladder pain 11.39 10.77 8 48352 470 29525697
Emotional distress 11.39 10.77 49 48311 13846 29512321
Anal haemorrhage 11.35 10.77 15 48345 1947 29524220
Skin tightness 11.33 10.77 15 48345 1949 29524218
Agranulocytosis 11.25 10.77 10 48350 20330 29505837
Intentional product use issue 11.20 10.77 34 48326 42464 29483703
Myxoedema 11.07 10.77 3 48357 14 29526153
Occupational exposure to air contaminants 11.00 10.77 5 48355 125 29526042
Sports injury 10.93 10.77 5 48355 127 29526040
Bulbar palsy 10.78 10.77 6 48354 233 29525934

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 571.02 10.09 1280 119216 223134 64155102
Atrial fibrillation 515.94 10.09 1046 119450 170043 64208193
Sedation complication 399.13 10.09 246 120250 10108 64368128
Creatinine renal clearance decreased 386.41 10.09 273 120223 14148 64364088
Cardiac failure congestive 349.83 10.09 761 119735 129819 64248417
Hypotension 337.89 10.09 1507 118989 379467 63998769
Bradycardia 328.15 10.09 699 119797 117520 64260716
Orthostatic hypotension 275.40 10.09 386 120110 46352 64331884
Off label use 253.02 10.09 501 119995 632305 63745931
Blood calcium decreased 235.42 10.09 264 120232 25290 64352946
Balance disorder 209.82 10.09 476 120020 83450 64294786
Sedation 198.99 10.09 311 120185 41151 64337085
Cognitive disorder 188.99 10.09 356 120140 54731 64323505
Dyspnoea 173.20 10.09 2075 118421 716599 63661637
Drug ineffective 168.18 10.09 905 119591 839342 63538894
Neutropenia 140.72 10.09 144 120352 239480 64138756
Febrile neutropenia 139.85 10.09 89 120407 187568 64190668
Fall 128.46 10.09 1265 119231 415561 63962675
Depressed level of consciousness 122.04 10.09 382 120114 81054 64297182
Toxicity to various agents 121.27 10.09 1122 119374 362391 64015845
Synovitis 120.73 10.09 20 120476 99070 64279166
Maternal exposure during pregnancy 119.88 10.09 18 120478 95866 64282370
Suspected suicide 107.65 10.09 105 120391 8549 64369687
Fluid retention 103.90 10.09 295 120201 59311 64318925
Chronic obstructive pulmonary disease 100.72 10.09 327 120169 70721 64307515
Dyspnoea exertional 97.98 10.09 332 120164 73398 64304838
Pulmonary arterial hypertension 90.80 10.09 167 120329 25200 64353036
Pemphigus 86.95 10.09 7 120489 60694 64317542
Therapeutic product effect decreased 86.87 10.09 54 120442 115297 64262939
Atrioventricular block complete 86.26 10.09 120 120376 14298 64363938
Hand deformity 85.21 10.09 9 120487 62762 64315474
Chest pain 85.02 10.09 741 119755 235239 64142997
Treatment failure 82.17 10.09 59 120437 116757 64261479
Myocardial infarction 79.82 10.09 557 119939 165264 64212972
Exposure during pregnancy 77.99 10.09 24 120472 77651 64300585
Product use in unapproved indication 76.27 10.09 133 120363 176485 64201751
BRASH syndrome 75.82 10.09 28 120468 349 64377887
Systemic lupus erythematosus rash 73.78 10.09 41 120455 1384 64376852
Atrial flutter 72.42 10.09 130 120366 19250 64358986
General physical health deterioration 72.09 10.09 173 120323 204252 64173984
Pericarditis 71.05 10.09 15 120481 62501 64315735
Product use issue 70.40 10.09 109 120387 151606 64226630
Nerve injury 70.09 10.09 79 120417 7606 64370630
Pyrexia 69.92 10.09 687 119809 557957 63820279
Coronary artery disease 69.88 10.09 260 120236 60173 64318063
Drug intolerance 69.58 10.09 155 120341 187837 64190399
Heart rate increased 68.81 10.09 365 120131 98310 64279926
Gastrointestinal haemorrhage 68.16 10.09 452 120044 131860 64246376
Cardiogenic shock 68.12 10.09 172 120324 32255 64345981
Rheumatoid arthritis 68.00 10.09 127 120369 164167 64214069
Cardiac arrest 67.50 10.09 506 119990 153558 64224678
Atrioventricular block second degree 65.19 10.09 70 120426 6384 64371852
Arthropathy 65.11 10.09 78 120418 120889 64257347
Mobility decreased 64.34 10.09 324 120172 85516 64292720
Constipation 61.90 10.09 678 119818 228659 64149577
Joint swelling 60.65 10.09 203 120293 215179 64163057
Thrombocytopenia 60.28 10.09 215 120281 223586 64154650
Respiratory tract congestion 59.85 10.09 108 120388 16057 64362179
Infusion related reaction 59.72 10.09 137 120359 164330 64213906
Labile blood pressure 59.50 10.09 41 120455 2039 64376197
Rash 57.69 10.09 563 119933 457986 63920250
Malignant neoplasm progression 57.38 10.09 76 120420 112795 64265441
Hepatic enzyme increased 56.86 10.09 97 120399 129846 64248390
Oedema peripheral 55.93 10.09 620 119876 209697 64168539
Dizziness 55.83 10.09 1120 119376 429043 63949193
Pancytopenia 55.65 10.09 115 120381 143194 64235042
Atrioventricular block first degree 54.97 10.09 83 120413 10651 64367585
Alopecia 53.94 10.09 146 120350 165544 64212692
Asthma 53.77 10.09 333 120163 94892 64283344
Atrioventricular block 53.33 10.09 87 120409 11928 64366308
Body tinea 53.10 10.09 32 120464 1261 64376975
Duodenal ulcer perforation 52.49 10.09 3 120493 34622 64343614
Angina pectoris 52.15 10.09 194 120302 44887 64333349
Palpitations 50.84 10.09 352 120144 104136 64274100
Glossodynia 50.51 10.09 29 120467 64667 64313569
Cerebrovascular accident 49.99 10.09 433 120063 137150 64241086
Bunion operation 49.98 10.09 26 120470 767 64377469
Nodal rhythm 49.77 10.09 42 120454 2832 64375404
Hypoxia 49.60 10.09 308 120188 87841 64290395
Discomfort 49.26 10.09 47 120449 80831 64297405
Inhibitory drug interaction 48.88 10.09 46 120450 3581 64374655
Contraindicated product administered 48.56 10.09 79 120417 107750 64270486
Incision site pain 48.48 10.09 40 120456 2614 64375622
Neutrophil count decreased 48.03 10.09 44 120452 77152 64301084
White blood cell count decreased 46.34 10.09 146 120350 157691 64220545
Death 45.58 10.09 1202 119294 481503 63896733
Stomatitis 44.22 10.09 86 120410 109519 64268717
Nephrolithiasis 44.03 10.09 180 120316 43503 64334733
Injection site erythema 43.28 10.09 41 120455 70759 64307477
Intentional product use issue 42.81 10.09 70 120426 95294 64282942
Urinary tract discomfort 42.73 10.09 18 120478 324 64377912
Pain in jaw 42.73 10.09 170 120326 40585 64337651
Alveolitis 42.60 10.09 43 120453 3649 64374587
Leukopenia 42.10 10.09 78 120418 101164 64277072
Pericardial haemorrhage 42.02 10.09 45 120451 4091 64374145
Systemic lupus erythematosus 41.80 10.09 50 120446 77562 64300674
Pulmonary congestion 41.41 10.09 118 120378 23762 64354474
Full blood count abnormal 40.40 10.09 135 120361 29622 64348614
Medication error 39.85 10.09 192 120304 49774 64328462
Musculoskeletal stiffness 39.76 10.09 109 120387 123097 64255139
Hunger 39.03 10.09 44 120452 4237 64373999
Mucosal inflammation 38.54 10.09 36 120460 62548 64315688
Cardiac disorder 37.89 10.09 205 120291 55611 64322625
Unevaluable event 36.72 10.09 189 120307 50300 64327936
Wound 36.37 10.09 54 120442 76423 64301813
Hypervolaemia 35.66 10.09 154 120342 38131 64340105
Heart rate decreased 35.21 10.09 199 120297 54868 64323368
Foot deformity 35.14 10.09 88 120408 16416 64361820
Limb injury 34.94 10.09 110 120386 23395 64354841
Productive cough 34.65 10.09 245 120251 72958 64305278
Infection susceptibility increased 33.76 10.09 33 120463 2693 64375543
Drug resistance 33.21 10.09 12 120484 35090 64343146
Therapeutic product effect incomplete 33.05 10.09 92 120404 103390 64274846
Alveolar osteitis 32.96 10.09 16 120480 406 64377830
Muscle relaxant therapy 31.50 10.09 12 120484 164 64378072
Bladder prolapse 31.49 10.09 22 120474 1119 64377117
Ill-defined disorder 31.29 10.09 22 120474 44030 64334206
Hepatic ischaemia 31.26 10.09 21 120475 1001 64377235
Conjunctivitis allergic 31.12 10.09 21 120475 1009 64377227
Pulmonary hypertension 30.34 10.09 160 120336 42979 64335257
Nodal arrhythmia 30.01 10.09 26 120470 1817 64376419
C-reactive protein increased 29.85 10.09 85 120411 94824 64283412
Chondrocalcinosis 29.81 10.09 18 120478 712 64377524
Angina unstable 29.36 10.09 79 120417 15388 64362848
Transfusion 29.36 10.09 87 120409 17907 64360329
Oedema 28.65 10.09 280 120216 91655 64286581
Abortion spontaneous 28.63 10.09 6 120490 25137 64353099
Oxygen saturation decreased 28.47 10.09 316 120180 106860 64271376
Prinzmetal angina 28.18 10.09 23 120473 1480 64376756
Blood pressure systolic increased 27.94 10.09 173 120323 49280 64328956
Kidney infection 27.93 10.09 85 120411 17753 64360483
Syncope 27.72 10.09 431 120065 157204 64221032
Bronchitis 27.70 10.09 318 120178 108425 64269811
Heart sounds 27.58 10.09 16 120480 587 64377649
Myopathy 27.45 10.09 84 120412 17596 64360640
Hyperkalaemia 27.24 10.09 299 120197 100830 64277406
Status epilepticus 27.22 10.09 4 120492 21659 64356577
Muscle injury 26.83 10.09 8 120488 26429 64351807
Poor quality sleep 26.64 10.09 87 120409 18864 64359372
Paranasal sinus discomfort 26.36 10.09 31 120465 3124 64375112
Cardioplegia 26.23 10.09 6 120490 9 64378227
Helicobacter infection 26.15 10.09 20 120476 38342 64339894
International normalised ratio increased 26.09 10.09 244 120252 78923 64299313
Bezoar 26.04 10.09 26 120470 2177 64376059
Pregnancy 25.88 10.09 4 120492 20861 64357375
Tunnel vision 25.86 10.09 19 120477 1046 64377190
Intentional self-injury 25.71 10.09 11 120485 29033 64349203
Distributive shock 25.69 10.09 24 120472 1851 64376385
Spirometry abnormal 25.60 10.09 15 120481 561 64377675
Atrial thrombosis 25.60 10.09 30 120466 3012 64375224
Drug interaction 25.53 10.09 870 119626 361213 64017023
Hepatic function abnormal 25.47 10.09 51 120445 64262 64313974
Aortic stenosis 25.47 10.09 44 120452 6321 64371915
Prolonged expiration 25.39 10.09 17 120479 806 64377430
Lower gastrointestinal haemorrhage 25.27 10.09 70 120426 13869 64364367
Erythrodermic psoriasis 25.16 10.09 22 120474 1557 64376679
Antiacetylcholine receptor antibody positive 25.15 10.09 8 120488 61 64378175
Bladder pain 24.80 10.09 23 120473 1758 64376478
Agranulocytosis 24.73 10.09 21 120475 38208 64340028
Pacemaker generated rhythm 24.71 10.09 8 120488 65 64378171
Heart rate irregular 24.56 10.09 109 120387 27304 64350932
Suicidal ideation 24.48 10.09 55 120441 66487 64311749
Nasal congestion 24.46 10.09 193 120303 59465 64318771
Cough 24.42 10.09 738 119758 301410 64076826
Injection site pruritus 24.19 10.09 21 120475 37805 64340431
Folliculitis 24.17 10.09 13 120483 30064 64348172
Blood iron decreased 24.04 10.09 63 120433 12079 64366157
Pneumonia 23.97 10.09 1276 119220 558300 63819936
Erythromelalgia 23.79 10.09 10 120486 179 64378057
Aspartate aminotransferase increased 23.76 10.09 129 120367 119659 64258577
Alanine aminotransferase increased 23.74 10.09 157 120339 138874 64239362
Bone marrow failure 23.64 10.09 33 120463 47919 64330317
Gastrointestinal disorder 23.58 10.09 87 120409 89622 64288614
Supraventricular tachycardia 23.24 10.09 83 120413 18824 64359412
Blue toe syndrome 22.95 10.09 14 120482 564 64377672
Bronchopulmonary aspergillosis 22.91 10.09 4 120492 19081 64359155
Asthenia 22.72 10.09 997 119499 427047 63951189
Mite allergy 22.46 10.09 15 120481 708 64377528
Arthralgia 22.40 10.09 642 119854 441618 63936618
Impaired quality of life 22.40 10.09 42 120454 6429 64371807
Septic shock 22.34 10.09 111 120385 105326 64272910
Pulmonary oedema 22.30 10.09 235 120261 78439 64299797
Wrong technique in product usage process 22.08 10.09 56 120440 64918 64313318
Abdominal pain 22.05 10.09 431 120065 311944 64066292
Neutropenic sepsis 21.94 10.09 8 120488 23264 64354972
Forced expiratory volume decreased 21.84 10.09 43 120453 6824 64371412
Arterial spasm 21.84 10.09 9 120487 153 64378083
Platelet count decreased 21.83 10.09 204 120292 167507 64210729
Coronary artery bypass 21.72 10.09 39 120457 5776 64372460
Aggression 21.63 10.09 33 120463 46199 64332037
Rectal prolapse 21.57 10.09 21 120475 1705 64376531
Neuroleptic malignant syndrome 21.29 10.09 10 120486 24986 64353250
Vasoplegia syndrome 21.17 10.09 26 120470 2741 64375495
Abnormal behaviour 21.10 10.09 19 120477 33603 64344633
Cytomegalovirus infection 21.07 10.09 23 120473 37176 64341060
Arteriovenous fistula occlusion 21.04 10.09 13 120483 536 64377700
Coagulopathy 20.83 10.09 116 120380 31804 64346432
Sopor 20.82 10.09 15 120481 29646 64348590
Pneumocystis jirovecii pneumonia 20.70 10.09 13 120483 27621 64350615
Blood loss anaemia 20.64 10.09 65 120431 13827 64364409
Disturbance in attention 20.52 10.09 28 120468 41046 64337190
Cardiac pacemaker insertion 20.46 10.09 35 120461 4988 64373248
Animal scratch 20.33 10.09 16 120480 977 64377259
Mycotic allergy 20.26 10.09 16 120480 982 64377254
Sleep disorder due to general medical condition, insomnia type 20.18 10.09 12 120484 26258 64351978
Glucose tolerance impaired 20.08 10.09 40 120456 6403 64371833
Posterior reversible encephalopathy syndrome 19.82 10.09 9 120487 22937 64355299
Gastrooesophageal reflux disease 19.78 10.09 240 120256 82903 64295333
Rales 19.71 10.09 68 120428 15161 64363075
Urticaria 19.69 10.09 178 120318 147139 64231097
Peak expiratory flow rate abnormal 19.66 10.09 7 120489 78 64378158
Myelosuppression 19.59 10.09 10 120486 23820 64354416
Dust allergy 19.50 10.09 16 120480 1037 64377199
Blood pressure diastolic decreased 19.47 10.09 88 120408 22213 64356023
Disease progression 19.46 10.09 170 120326 141510 64236726
Ear congestion 19.43 10.09 22 120474 2128 64376108
Aortic arteriosclerosis 19.33 10.09 43 120453 7433 64370803
Psoriatic arthropathy 19.21 10.09 32 120464 43249 64334987
Red blood cell sedimentation rate increased 19.19 10.09 18 120478 31217 64347019
Obstructive airways disorder 19.14 10.09 90 120406 23095 64355141
Acute myeloid leukaemia 19.13 10.09 14 120482 27449 64350787
Osteonecrosis of jaw 19.05 10.09 28 120468 39797 64338439
Liver disorder 18.90 10.09 45 120451 53306 64324930
Seizure 18.84 10.09 210 120286 166682 64211554
Hyperbilirubinaemia 18.82 10.09 8 120488 21197 64357039
Torsade de pointes 18.66 10.09 73 120423 17290 64360946
Atrioventricular dissociation 18.62 10.09 10 120486 315 64377921
Vomiting 18.58 10.09 841 119655 550276 63827960
Aspergillus infection 18.46 10.09 4 120492 16375 64361861
Haemarthrosis 18.18 10.09 34 120462 5195 64373041
Gouty tophus 18.15 10.09 10 120486 332 64377904
Wound complication 18.08 10.09 29 120467 3919 64374317
Gamma-glutamyltransferase increased 17.92 10.09 40 120456 48470 64329766
Arrhythmia 17.86 10.09 164 120332 52780 64325456
Thermal burn 17.61 10.09 36 120460 5870 64372366
Arrhythmogenic right ventricular dysplasia 17.51 10.09 5 120491 25 64378211
Respiratory acidosis 17.38 10.09 49 120447 9806 64368430
Carbon dioxide increased 17.38 10.09 20 120476 1969 64376267
Presyncope 16.93 10.09 118 120378 34971 64343265
Psychotic disorder 16.84 10.09 24 120472 34554 64343682
Renal pain 16.79 10.09 39 120457 6935 64371301
Feeling cold 16.77 10.09 88 120408 23590 64354646
Myocardial hypoxia 16.76 10.09 4 120492 8 64378228
Toxic optic neuropathy 16.73 10.09 14 120482 933 64377303
Muscle strain 16.72 10.09 43 120453 8151 64370085
Haemophagocytic lymphohistiocytosis 16.69 10.09 6 120490 17603 64360633
Epilepsy 16.60 10.09 23 120473 33508 64344728
Heart rate abnormal 16.59 10.09 32 120464 5003 64373233
Blood urine present 16.49 10.09 73 120423 18267 64359969
Hepatotoxicity 16.42 10.09 31 120465 39931 64338305
Liver injury 16.42 10.09 19 120477 29913 64348323
Irritable bowel syndrome 16.24 10.09 28 120468 37341 64340895
Oxygen consumption increased 16.19 10.09 30 120466 4551 64373685
Nephroangiosclerosis 16.14 10.09 9 120487 306 64377930
Dysphagia 16.10 10.09 125 120371 106687 64271549
Injection site pain 16.05 10.09 132 120364 111276 64266960
Hyperlipidaemia 16.01 10.09 85 120411 22891 64355345
Anaphylactic reaction 15.89 10.09 70 120426 68594 64309642
Sepsis 15.88 10.09 319 120177 230022 64148214
Renal injury 15.88 10.09 64 120432 15365 64362871
Cardiac ablation 15.79 10.09 18 120478 1754 64376482
Blood bilirubin increased 15.66 10.09 55 120441 57498 64320738
Device pacing issue 15.49 10.09 6 120490 86 64378150
Red blood cells urine positive 15.42 10.09 29 120467 4449 64373787
Polyneuropathy 15.41 10.09 9 120487 19885 64358351
Humidity intolerance 15.37 10.09 9 120487 336 64377900
Electrocardiogram QRS complex prolonged 15.37 10.09 45 120451 9199 64369037
Foot operation 15.30 10.09 28 120468 4207 64374029
Aspiration pleural cavity 15.27 10.09 16 120480 1419 64376817
Acute lung injury 15.25 10.09 22 120474 2709 64375527
Ventricular fibrillation 15.10 10.09 86 120410 23774 64354462
Tendon pain 14.99 10.09 30 120466 4818 64373418
Premature delivery 14.99 10.09 8 120488 18581 64359655
Catheter site erythema 14.98 10.09 30 120466 4819 64373417
Hospitalisation 14.92 10.09 210 120286 74997 64303239
Catheter site haemorrhage 14.91 10.09 29 120467 4562 64373674
Cardioversion 14.89 10.09 18 120478 1867 64376369
Chest discomfort 14.89 10.09 302 120194 115804 64262432
Myocardial ischaemia 14.84 10.09 84 120412 23167 64355069
Sinus bradycardia 14.81 10.09 83 120413 22810 64355426
Cardiac valve disease 14.71 10.09 31 120465 5164 64373072
Polymyalgia rheumatica 14.47 10.09 24 120472 3335 64374901
Coma 14.42 10.09 100 120396 87515 64290721
Wheezing 14.41 10.09 221 120275 80358 64297878
Stent placement 14.35 10.09 32 120464 5539 64372697
Pulmonary function test decreased 14.33 10.09 35 120461 6426 64371810
Multiple sclerosis relapse 14.33 10.09 35 120461 41100 64337136
Disseminated intravascular coagulation 14.28 10.09 24 120472 32324 64345912
Eczema infected 14.18 10.09 5 120491 54 64378182
Renal failure 14.18 10.09 442 120054 181246 64196990
Sebaceous gland infection 14.14 10.09 6 120490 110 64378126
Interstitial lung disease 13.98 10.09 116 120380 97616 64280620
Drug reaction with eosinophilia and systemic symptoms 13.97 10.09 53 120443 54164 64324072
Fibrous histiocytoma 13.96 10.09 10 120486 529 64377707
Cardioactive drug level increased 13.92 10.09 24 120472 3441 64374795
Electrocardiogram U wave present 13.85 10.09 6 120490 116 64378120
Tooth infection 13.80 10.09 59 120437 14542 64363694
Inflammation 13.68 10.09 69 120427 65231 64313005
Bronchopulmonary aspergillosis allergic 13.65 10.09 16 120480 1606 64376630
Skin laceration 13.53 10.09 85 120411 24332 64353904
Metastases to bone 13.49 10.09 11 120485 20424 64357812
Mast cell degranulation present 13.49 10.09 5 120491 63 64378173
Pruritus 13.49 10.09 463 120033 311937 64066299
Neoplasm progression 13.39 10.09 36 120460 40928 64337308
Vitamin D decreased 13.34 10.09 38 120458 7649 64370587
Serotonin syndrome 13.23 10.09 34 120462 39248 64338988
Confusional state 13.22 10.09 379 120117 260765 64117471
Gallbladder polyp 13.13 10.09 12 120484 900 64377336
Progressive multifocal leukoencephalopathy 13.09 10.09 9 120487 18223 64360013
Palmar-plantar erythrodysaesthesia syndrome 13.07 10.09 21 120475 28798 64349438
Ventricular tachycardia 13.04 10.09 109 120387 34156 64344080
Restlessness 12.97 10.09 35 120461 39750 64338486
Weight decreased 12.88 10.09 655 119841 285084 64093152
Tetany 12.87 10.09 18 120478 2154 64376082
Rectal haemorrhage 12.82 10.09 174 120322 61643 64316593
Neuropathy peripheral 12.82 10.09 149 120347 117376 64260860
Myocarditis 12.79 10.09 8 120488 17035 64361201
Colon gangrene 12.75 10.09 4 120492 29 64378207
Suicide attempt 12.72 10.09 79 120417 70928 64307308
Altered state of consciousness 12.62 10.09 33 120463 37869 64340367
Hepatorenal syndrome 12.58 10.09 24 120472 3722 64374514
Sleep disorder 12.57 10.09 63 120433 59646 64318590
Arteriospasm coronary 12.55 10.09 30 120466 5435 64372801
Inappropriate schedule of product administration 12.55 10.09 111 120385 92175 64286061
Injection site inflammation 12.54 10.09 22 120474 3199 64375037
Bradyarrhythmia 12.52 10.09 24 120472 3734 64374502
Incision site haemorrhage 12.52 10.09 12 120484 956 64377280
Protein urine present 12.48 10.09 41 120455 8915 64369321
Embolic stroke 12.46 10.09 34 120462 6677 64371559
Catheter site discharge 12.44 10.09 18 120478 2223 64376013
Anuria 12.43 10.09 69 120427 18895 64359341
Encephalitis 12.41 10.09 4 120492 12567 64365669
Sinoatrial block 12.40 10.09 13 120483 1153 64377083
Histoplasmosis 12.35 10.09 17 120479 2005 64376231
Ectopic ACTH syndrome 12.33 10.09 6 120490 153 64378083
Pain in extremity 12.31 10.09 688 119808 302397 64075839
Coronary artery occlusion 12.27 10.09 55 120441 13836 64364400
Muscle disorder 12.27 10.09 28 120468 4923 64373313
Ventricular arrhythmia 12.24 10.09 36 120460 7379 64370857
Enlarged uvula 12.20 10.09 8 120488 366 64377870
Pulmonary embolism 12.20 10.09 196 120300 146160 64232076
Oxygen therapy 12.12 10.09 18 120478 2275 64375961
Brain oedema 12.12 10.09 14 120482 22061 64356175
Live birth 12.11 10.09 3 120493 11201 64367035
Sinus node dysfunction 12.09 10.09 34 120462 6794 64371442
Drug hypersensitivity 12.07 10.09 345 120151 237470 64140766
Schizophrenia 12.05 10.09 3 120493 11165 64367071
Iron deficiency anaemia 12.00 10.09 76 120420 21813 64356423
Acute generalised exanthematous pustulosis 11.92 10.09 55 120441 14003 64364233
Catheter site pain 11.91 10.09 26 120470 4436 64373800
Sinus arrest 11.89 10.09 21 120475 3069 64375167
Catheter management 11.89 10.09 22 120474 3333 64374903
Eosinophilic pleural effusion 11.85 10.09 7 120489 266 64377970
Sinus pain 11.83 10.09 19 120477 2570 64375666
Mitral valve incompetence 11.80 10.09 85 120411 25453 64352783
Coronary arterial stent insertion 11.75 10.09 30 120466 5662 64372574
Anion gap abnormal 11.71 10.09 9 120487 531 64377705
Shock 11.68 10.09 116 120380 38124 64340112
Cardiac failure 11.68 10.09 327 120169 132046 64246190
Cytokine release syndrome 11.66 10.09 13 120483 20816 64357420
Gravitational oedema 11.66 10.09 15 120481 1657 64376579
Stupor 11.63 10.09 31 120465 6004 64372232
Blister 11.63 10.09 96 120400 80871 64297365
Generalised tonic-clonic seizure 11.59 10.09 37 120459 39820 64338416
Peritonitis 11.57 10.09 18 120478 25005 64353231
Seasonal allergy 11.56 10.09 48 120448 11678 64366558
Cholangitis 11.46 10.09 3 120493 10799 64367437
Drug abuse 11.46 10.09 176 120320 132198 64246038
Bladder disorder 11.22 10.09 36 120460 7731 64370505
Coronary artery restenosis 11.22 10.09 13 120483 1289 64376947
Aplastic anaemia 11.21 10.09 6 120490 13914 64364322
Metastases to central nervous system 11.20 10.09 6 120490 13906 64364330
Erythema 11.18 10.09 265 120231 186805 64191431
Extrapyramidal disorder 11.17 10.09 12 120484 19540 64358696
Orthopnoea 11.14 10.09 40 120456 9094 64369142
Influenza virus test positive 11.13 10.09 7 120489 298 64377938
Bronchiectasis 11.03 10.09 54 120442 14086 64364150
Infusion site erythema 10.99 10.09 33 120463 6840 64371396
Acute respiratory failure 10.96 10.09 142 120354 49792 64328444
Pulseless electrical activity 10.92 10.09 50 120446 12689 64365547
Jaundice 10.90 10.09 50 120446 48462 64329774
Emotional distress 10.85 10.09 109 120387 35929 64342307
Urticarial vasculitis 10.85 10.09 8 120488 443 64377793
Deep vein thrombosis 10.84 10.09 135 120361 105047 64273189
Cellulitis 10.83 10.09 240 120256 93417 64284819
Right ventricular failure 10.83 10.09 73 120423 21398 64356838
Leukaemoid reaction 10.78 10.09 7 120489 315 64377921
COVID-19 pneumonia 10.75 10.09 9 120487 16495 64361741
Respiration abnormal 10.75 10.09 31 120465 6284 64371952
Infection 10.75 10.09 263 120233 184617 64193619
Motion sickness 10.74 10.09 10 120486 768 64377468
Spondyloarthropathy 10.65 10.09 10 120486 776 64377460
Transaminases increased 10.60 10.09 45 120451 44549 64333687
Peripheral swelling 10.59 10.09 485 120011 208668 64169568
Electrocardiogram QT shortened 10.55 10.09 6 120490 212 64378024
Arteriosclerosis coronary artery 10.51 10.09 57 120439 15472 64362764
Lymphopenia 10.45 10.09 20 120476 25637 64352599
Fear 10.43 10.09 69 120427 20102 64358134
Febrile bone marrow aplasia 10.39 10.09 4 120492 11251 64366985
Skin necrosis 10.38 10.09 7 120489 14322 64363914
Nausea 10.37 10.09 1298 119198 784502 63593734
Occupational exposure to air contaminants 10.37 10.09 5 120491 125 64378111
Accidental exposure to product 10.36 10.09 21 120475 26343 64351893
Perineal pain 10.34 10.09 11 120485 992 64377244
Depression 10.31 10.09 262 120234 183029 64195207
Injection site swelling 10.29 10.09 41 120455 41312 64336924
Injection site urticaria 10.28 10.09 4 120492 11177 64367059
Mastication disorder 10.25 10.09 17 120479 2362 64375874
Hallucination, auditory 10.13 10.09 10 120486 16929 64361307
Ataxia 10.10 10.09 16 120480 22068 64356168

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C05AE03 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Muscle relaxants
ATC C08DB01 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS
Benzothiazepine derivatives
FDA MoA N0000000069 Calcium Channel Antagonists
FDA EPC N0000175566 Calcium Channel Blocker
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D014665 Vasodilator Agents
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:38215 calcium channel blockers

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Atrial fibrillation indication 49436004 DOID:0060224
Paroxysmal supraventricular tachycardia indication 67198005
Prinzmetal angina indication 87343002
Angina pectoris indication 194828000
Anal fissure off-label use 30037006
Supraventricular arrhythmia off-label use 72654001
Diastolic heart failure off-label use 418304008 DOID:9775
Hyperkalemia contraindication 14140009
Ventricular tachycardia contraindication 25569003
Complete atrioventricular block contraindication 27885002
Acute cerebrovascular insufficiency contraindication 29322000
Sick sinus syndrome contraindication 36083008 DOID:13884
Immunosuppression contraindication 38013005
Angioedema contraindication 41291007 DOID:1558
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Lown-Ganong-Levine syndrome contraindication 55475008 DOID:13087
Aortic valve stenosis contraindication 60573004 DOID:1712
Wolff-Parkinson-White pattern contraindication 74390002 DOID:384
Transplantation contraindication 77465005
Chronic idiopathic constipation contraindication 82934008
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Disorder of connective tissue contraindication 105969002 DOID:65
Second degree atrioventricular block contraindication 195042002
Decompensated cardiac failure contraindication 195111005
Hypertrophic cardiomyopathy contraindication 233873004 DOID:11984
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Left ventricular cardiac dysfunction contraindication 429589006
Hemodialysis with High-Flux Membrane contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.63 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel BLOCKER IC50 7.32 WOMBAT-PK CHEMBL
Cytochrome P450 3A4 Enzyme IC50 5.74 DRUG MATRIX
Multidrug resistance protein 1 Transporter IC50 4.37 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 5.62 PDSP
5-hydroxytryptamine receptor 3A Ion channel BLOCKER IC50 4.68 IUPHAR
Voltage-dependent calcium channel gamma-1 subunit Ion channel IC50 6.10 WOMBAT-PK
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel Ki 4.02 WOMBAT-PK
Voltage-dependent L-type calcium channel subunit alpha-1S Ion channel Ki 6.42 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.91 CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 4.35 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 4.76 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel IC50 4.52 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel IC50 7.27 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1D Ion channel IC50 7.34 CHEMBL
5-hydroxytryptamine receptor 3A Ion channel BLOCKER IC50 5.26 IUPHAR
Voltage-gated L-type calcium channel Ion channel Ki 7.80 CHEMBL
Potassium voltage-gated channel subfamily C member 1 Ion channel BLOCKER IC50 4 IUPHAR
Potassium voltage-gated channel subfamily A member 7 Ion channel BLOCKER IC50 4.20 IUPHAR
Voltage-dependent L-type calcium channel subunit alpha-1F Ion channel BLOCKER IC50 4 IUPHAR

External reference:

IDSource
4020128 VUID
N0000179650 NUI
D00616 KEGG_DRUG
33286-22-5 SECONDARY_CAS_RN
144604-00-2 SECONDARY_CAS_RN
203211 RXNORM
4018817 VANDF
4019722 VANDF
4020128 VANDF
CHEBI:101278 CHEBI
C9F PDB_CHEM_ID
CHEMBL23 ChEMBL_ID
CHEMBL1697 ChEMBL_ID
CHEMBL1200805 ChEMBL_ID
2298 IUPHAR_LIGAND_ID
3433 INN_ID
DB00343 DRUGBANK_ID
EE92BBP03H UNII
39186 PUBCHEM_CID
1547 MMSL
4604 MMSL
d00045 MMSL
000711 NDDF
004514 NDDF
007237 NDDF
12218006 SNOMEDCT_US
372793000 SNOMEDCT_US
59941008 SNOMEDCT_US
D004110 MESH_DESCRIPTOR_UI
C0012373 UMLSCUI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Diltiazem Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0318 TABLET, FILM COATED 30 mg ORAL ANDA 18 sections
Diltiazem Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0319 TABLET, FILM COATED 60 mg ORAL ANDA 18 sections
Diltiazem Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0320 TABLET, FILM COATED 90 mg ORAL ANDA 18 sections
Diltiazem Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0321 TABLET, FILM COATED 120 mg ORAL ANDA 18 sections
Cardizem HUMAN PRESCRIPTION DRUG LABEL 1 0187-0771 TABLET, COATED 30 mg ORAL NDA 21 sections
Cardizem HUMAN PRESCRIPTION DRUG LABEL 1 0187-0772 TABLET, COATED 60 mg ORAL NDA 21 sections
Cardizem HUMAN PRESCRIPTION DRUG LABEL 1 0187-0791 TABLET, COATED 90 mg ORAL NDA 21 sections
Cardizem HUMAN PRESCRIPTION DRUG LABEL 1 0187-0792 TABLET, COATED 120 mg ORAL NDA 21 sections
Cardizem CD HUMAN PRESCRIPTION DRUG LABEL 1 0187-0795 CAPSULE, COATED, EXTENDED RELEASE 120 mg ORAL NDA 14 sections
Cardizem CD HUMAN PRESCRIPTION DRUG LABEL 1 0187-0796 CAPSULE, COATED, EXTENDED RELEASE 180 mg ORAL NDA 14 sections
Cardizem CD HUMAN PRESCRIPTION DRUG LABEL 1 0187-0797 CAPSULE, COATED, EXTENDED RELEASE 240 mg ORAL NDA 14 sections
Cardizem CD HUMAN PRESCRIPTION DRUG LABEL 1 0187-0798 CAPSULE, COATED, EXTENDED RELEASE 300 mg ORAL NDA 14 sections
Cardizem CD HUMAN PRESCRIPTION DRUG LABEL 1 0187-0799 CAPSULE, COATED, EXTENDED RELEASE 360 mg ORAL NDA 14 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2045 TABLET, EXTENDED RELEASE 120 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2046 TABLET, EXTENDED RELEASE 180 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2047 TABLET, EXTENDED RELEASE 240 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2048 TABLET, EXTENDED RELEASE 300 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2049 TABLET, EXTENDED RELEASE 360 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2050 TABLET, EXTENDED RELEASE 420 mg ORAL NDA 25 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2612 CAPSULE, EXTENDED RELEASE 120 mg ORAL NDA 23 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2613 CAPSULE, EXTENDED RELEASE 180 mg ORAL NDA 23 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2614 CAPSULE, EXTENDED RELEASE 240 mg ORAL NDA 23 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2615 CAPSULE, EXTENDED RELEASE 300 mg ORAL NDA 23 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2616 CAPSULE, EXTENDED RELEASE 360 mg ORAL NDA 23 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2617 CAPSULE, EXTENDED RELEASE 420 mg ORAL NDA 23 sections
Diltiazem Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0228-2918 CAPSULE, EXTENDED RELEASE 360 mg ORAL ANDA 20 sections
Diltiazem Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-6060 CAPSULE, EXTENDED RELEASE 60 mg ORAL ANDA 20 sections
Diltiazem Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-6090 CAPSULE, EXTENDED RELEASE 90 mg ORAL ANDA 20 sections
Diltiazem Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-6120 CAPSULE, EXTENDED RELEASE 120 mg ORAL ANDA 20 sections
Diltiazem Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1171 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 24 sections