diltiazem 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, diltiazem derivatives 897 42399-41-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • (+)-Diltiazem
  • dilzem
  • d-Diltiazem
  • d-cis-Diltiazem
  • diltiazem hydrochloride
  • diltiazem malate
  • diltiazem
  • diltiazem HCl
A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
  • Molecular weight: 414.52
  • Formula: C22H26N2O4S
  • CLOGP: 3.65
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 59.08
  • ALOGS: -4.39
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.24 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 19.30 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 38 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 13 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.18 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 5, 1982 FDA VALEANT INTL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sedation complication 611.73 10.05 346 106534 13476 63368666
Creatinine renal clearance decreased 571.39 10.05 351 106529 15957 63366185
Atrial fibrillation 569.05 10.05 833 106047 115803 63266339
Orthostatic hypotension 525.87 10.05 457 106423 35703 63346439
Completed suicide 505.71 10.05 891 105989 144782 63237360
Hypotension 440.42 10.05 1226 105654 271378 63110764
Blood calcium decreased 410.42 10.05 347 106533 26104 63356038
Sedation 394.28 10.05 402 106478 38407 63343735
Balance disorder 360.52 10.05 567 106313 83855 63298287
Cognitive disorder 335.38 10.05 441 106439 55374 63326768
Depressed level of consciousness 290.38 10.05 435 106445 61643 63320499
Cardiac failure congestive 275.81 10.05 530 106350 91903 63290239
Toxicity to various agents 270.05 10.05 972 105908 246278 63135864
Maternal exposure during pregnancy 244.18 10.05 39 106841 220023 63162119
Bradycardia 235.98 10.05 434 106446 72793 63309349
Fall 225.88 10.05 1275 105605 391059 62991083
Drug ineffective 222.44 10.05 957 105923 1043808 62338334
Pemphigus 205.06 10.05 32 106848 183694 63198448
Off label use 189.84 10.05 548 106332 673914 62708228
Synovitis 180.55 10.05 46 106834 186872 63195270
Treatment failure 168.82 10.05 62 106818 198981 63183161
Hand deformity 168.64 10.05 32 106848 159425 63222717
Systemic lupus erythematosus 165.87 10.05 72 106808 208846 63173296
Nerve injury 165.68 10.05 136 106744 9810 63372332
Drug intolerance 160.25 10.05 170 106710 308491 63073651
Glossodynia 154.61 10.05 54 106826 178822 63203320
Alopecia 145.83 10.05 214 106666 337322 63044820
Dyspnoea 141.93 10.05 1717 105163 659596 62722546
Product use issue 141.73 10.05 99 106781 220421 63161721
Exposure during pregnancy 141.40 10.05 43 106837 155504 63226638
Arthropathy 136.19 10.05 117 106763 234675 63147467
Nephrolithiasis 134.14 10.05 248 106632 41736 63340406
Rheumatoid arthritis 132.58 10.05 139 106741 253680 63128462
Wound 131.58 10.05 55 106825 163208 63218934
Constipation 129.72 10.05 732 106148 224211 63157931
Therapeutic product effect decreased 129.14 10.05 83 106797 193104 63189038
Hepatic enzyme increased 127.17 10.05 93 106787 202235 63179907
Pulmonary congestion 122.60 10.05 149 106731 17269 63364873
Heart rate increased 117.90 10.05 388 106492 93850 63288292
Discomfort 117.31 10.05 68 106812 167306 63214836
Anti-cyclic citrullinated peptide antibody positive 117.30 10.05 26 106854 116186 63265956
Dyspnoea exertional 116.09 10.05 290 106590 60012 63322130
Rheumatoid factor positive 114.10 10.05 7 106873 84399 63297743
Systemic lupus erythematosus rash 112.28 10.05 61 106819 2191 63379951
Joint swelling 111.50 10.05 241 106639 327425 63054717
Pericarditis 111.50 10.05 41 106839 131538 63250604
Infusion related reaction 110.60 10.05 151 106729 245370 63136772
Atrioventricular block complete 109.36 10.05 99 106781 8152 63373990
Urinary tract discomfort 108.06 10.05 41 106839 619 63381523
Neutropenia 104.16 10.05 85 106795 174920 63207222
Contraindicated product administered 101.96 10.05 130 106750 217518 63164624
Suspected suicide 99.45 10.05 85 106795 6483 63375659
Alveolar osteitis 99.01 10.05 42 106838 859 63381283
Febrile neutropenia 92.10 10.05 42 106838 118407 63263735
Tunnel vision 86.95 10.05 42 106838 1174 63380968
Rash 85.66 10.05 573 106307 560298 62821844
Musculoskeletal stiffness 82.64 10.05 114 106766 184504 63197638
Abdominal discomfort 82.59 10.05 271 106609 320614 63061528
Fluid retention 82.15 10.05 254 106626 59432 63322710
Respiratory tract congestion 81.95 10.05 124 106756 17708 63364434
Mobility decreased 78.34 10.05 407 106473 120752 63261390
Animal scratch 77.98 10.05 41 106839 1377 63380765
Duodenal ulcer perforation 77.62 10.05 25 106855 87184 63294958
Body tinea 77.52 10.05 45 106835 1840 63380302
Labile blood pressure 77.01 10.05 44 106836 1745 63380397
Inhibitory drug interaction 76.75 10.05 52 106828 2797 63379345
Pulmonary arterial hypertension 76.72 10.05 137 106743 22440 63359702
Bladder pain 76.57 10.05 48 106832 2260 63379882
Gastrointestinal haemorrhage 75.06 10.05 303 106577 80873 63301269
Rales 72.63 10.05 98 106782 12599 63369543
Atrioventricular block second degree 72.59 10.05 57 106823 3857 63378285
Bunion operation 72.06 10.05 38 106842 1284 63380858
Paranasal sinus discomfort 71.13 10.05 59 106821 4317 63377825
General physical health deterioration 70.21 10.05 146 106734 201256 63180886
Pericardial haemorrhage 70.18 10.05 40 106840 1579 63380563
Limb injury 68.56 10.05 140 106740 25337 63356805
Pneumonia 65.13 10.05 1105 105775 455662 62926480
Myopathy 64.97 10.05 87 106793 11104 63371038
Chest pain 64.42 10.05 600 106280 215359 63166783
Hunger 62.53 10.05 60 106820 5319 63376823
Chronic obstructive pulmonary disease 61.99 10.05 239 106641 62447 63319695
Wound complication 61.91 10.05 51 106829 3696 63378446
Ear congestion 61.85 10.05 45 106835 2714 63379428
Blood iron decreased 61.54 10.05 98 106782 14623 63367519
Bronchopulmonary aspergillosis allergic 60.32 10.05 41 106839 2217 63379925
Polymyalgia rheumatica 59.32 10.05 50 106830 3741 63378401
Therapeutic product effect incomplete 59.24 10.05 74 106806 124982 63257160
Helicobacter infection 59.09 10.05 42 106838 92743 63289399
Cardiogenic shock 57.35 10.05 106 106774 17826 63364316
Intentional product use issue 57.18 10.05 79 106801 127813 63254329
Drug interaction 56.47 10.05 612 106268 228519 63153623
Infection susceptibility increased 54.19 10.05 46 106834 3475 63378667
Atrial flutter 53.74 10.05 74 106806 9698 63372444
Bronchitis 53.47 10.05 377 106503 124558 63257584
Alveolitis 53.09 10.05 42 106838 2873 63379269
Liver injury 52.71 10.05 18 106862 60502 63321640
Malignant neoplasm progression 52.52 10.05 37 106843 82084 63300058
Death 51.96 10.05 902 105978 373479 63008663
Asthma 51.75 10.05 380 106500 127181 63254961
Abortion spontaneous 50.87 10.05 9 106871 47186 63334956
Blood pressure systolic increased 50.42 10.05 185 106695 47212 63334930
Nodal rhythm 49.80 10.05 33 106847 1710 63380432
Heart rate decreased 49.45 10.05 179 106701 45381 63336761
Sinus pain 49.33 10.05 43 106837 3367 63378775
Leukopenia 49.20 10.05 35 106845 77255 63304887
Cough 49.12 10.05 728 106152 292015 63090127
Swollen joint count increased 48.69 10.05 3 106877 36051 63346091
BRASH syndrome 48.69 10.05 21 106859 448 63381694
Pain in jaw 48.15 10.05 172 106708 43324 63338818
Cardiac disorder 48.01 10.05 191 106689 50625 63331517
Poor quality sleep 47.21 10.05 104 106776 19831 63362311
C-reactive protein abnormal 47.13 10.05 10 106870 46086 63336056
Product use in unapproved indication 46.87 10.05 150 106730 178930 63203212
Condition aggravated 46.85 10.05 442 106438 401775 62980367
Atrioventricular block 46.78 10.05 61 106819 7586 63374556
Coronary artery disease 45.67 10.05 139 106741 32238 63349904
Angina pectoris 45.14 10.05 132 106748 29946 63352196
Rheumatic fever 44.81 10.05 9 106871 43102 63339040
Hepatic ischaemia 44.67 10.05 22 106858 642 63381500
Renal failure 44.07 10.05 344 106536 117308 63264834
Feeling cold 43.99 10.05 113 106767 23775 63358367
Full blood count abnormal 43.65 10.05 135 106745 31582 63350560
Stomatitis 43.10 10.05 107 106773 138618 63243524
Cardiac failure 42.93 10.05 277 106603 88865 63293277
Oedema peripheral 42.50 10.05 497 106383 189014 63193128
C-reactive protein increased 41.83 10.05 59 106821 94648 63287494
Wound secretion 41.83 10.05 45 106835 4569 63377573
Injection site erythema 41.75 10.05 47 106833 83127 63299015
Heart sounds 41.55 10.05 24 106856 972 63381170
Cellulitis 41.52 10.05 258 106622 81700 63300442
Hypoxia 41.52 10.05 205 106675 59587 63322555
Arthralgia 41.23 10.05 693 106187 569017 62813125
Folliculitis 40.76 10.05 35 106845 70282 63311860
Pulmonary hypertension 40.41 10.05 146 106734 36977 63345165
Kidney infection 39.99 10.05 107 106773 23069 63359073
Palpitations 39.66 10.05 325 106555 112445 63269697
Glucose tolerance impaired 39.52 10.05 52 106828 6525 63375617
Psoriatic arthropathy 39.45 10.05 58 106822 91462 63290680
Prolonged expiration 39.42 10.05 24 106856 1072 63381070
Skin laceration 39.34 10.05 105 106775 22603 63359539
Obstructive airways disorder 39.24 10.05 99 106781 20600 63361542
Torsade de pointes 39.08 10.05 76 106804 13275 63368867
White blood cell count decreased 38.90 10.05 113 106767 138991 63243151
Pregnancy 37.64 10.05 8 106872 36828 63345314
Cardiac ablation 37.39 10.05 26 106854 1459 63380683
Thrombocytopenia 37.23 10.05 130 106750 151027 63231115
Syncope 36.92 10.05 330 106550 117055 63265087
Bezoar 36.75 10.05 26 106854 1500 63380642
Myocardial infarction 36.27 10.05 290 106590 99603 63282539
Forced expiratory volume decreased 35.78 10.05 43 106837 4925 63377217
Tooth infection 35.33 10.05 87 106793 17833 63364309
Nasal polyps 35.13 10.05 47 106833 5992 63376150
Foot deformity 35.08 10.05 115 106765 27738 63354404
Myocardial hypoxia 34.35 10.05 8 106872 16 63382126
Atrioventricular block first degree 34.02 10.05 51 106829 7222 63374920
Pollakiuria 33.99 10.05 114 106766 27823 63354319
Pancytopenia 33.98 10.05 70 106810 96863 63285279
Swelling 33.15 10.05 300 106580 275078 63107064
Blood urine present 32.77 10.05 76 106804 14993 63367149
Cardiac arrest 32.69 10.05 267 106613 92278 63289864
Disease progression 32.69 10.05 102 106778 122656 63259486
Muscle relaxant therapy 32.52 10.05 12 106868 167 63381975
Red blood cell sedimentation rate increased 32.04 10.05 17 106863 43965 63338177
Hospitalisation 31.98 10.05 249 106631 84832 63297310
Mucosal inflammation 31.54 10.05 20 106860 46908 63335234
Oxygen saturation decreased 31.52 10.05 256 106624 88329 63293813
Bronchiectasis 31.43 10.05 78 106802 16064 63366078
Productive cough 31.40 10.05 198 106682 63010 63319132
Dizziness 31.32 10.05 946 105934 428979 62953163
Ill-defined disorder 31.31 10.05 56 106824 81699 63300443
Transfusion 31.20 10.05 75 106805 15142 63367000
Hypervolaemia 31.14 10.05 112 106768 28301 63353841
Oedema 30.98 10.05 275 106605 97347 63284795
Weight decreased 30.83 10.05 645 106235 276153 63105989
Bladder prolapse 30.81 10.05 27 106853 2129 63380013
Muscle injury 30.59 10.05 39 106841 65306 63316836
Neutrophil count decreased 30.41 10.05 30 106850 56376 63325766
Vasoplegia syndrome 29.91 10.05 24 106856 1675 63380467
Intentional self-injury 29.73 10.05 4 106876 25683 63356459
Hepatorenal syndrome 29.24 10.05 25 106855 1907 63380235
Hepatotoxicity 28.99 10.05 13 106867 37028 63345114
Blood cholesterol increased 28.83 10.05 73 106807 93959 63288183
Sinus disorder 28.82 10.05 99 106781 24454 63357688
Foetal exposure during pregnancy 28.72 10.05 9 106871 31953 63350189
Sebaceous gland infection 28.64 10.05 11 106869 172 63381970
Pulseless electrical activity 28.64 10.05 48 106832 7473 63374669
Erythrodermic psoriasis 28.43 10.05 19 106861 999 63381143
Blood pressure increased 28.30 10.05 406 106474 161656 63220486
Allergy to venom 28.18 10.05 6 106874 6 63382136
Unevaluable event 28.08 10.05 165 106715 51221 63330921
Asthenia 27.90 10.05 844 106036 382760 62999382
Gastrointestinal disorder 27.74 10.05 120 106760 131119 63251023
Erythromelalgia 27.11 10.05 10 106870 139 63382003
Incision site haemorrhage 26.84 10.05 15 106865 570 63381572
Irritable bowel syndrome 26.83 10.05 62 106818 82350 63299792
Arteriovenous fistula occlusion 26.83 10.05 13 106867 366 63381776
Hyperglycaemia 26.59 10.05 140 106740 41727 63340415
Thermal burn 26.31 10.05 41 106839 6005 63376137
Impaired quality of life 26.21 10.05 66 106814 13717 63368425
Pulmonary oedema 26.09 10.05 170 106710 54703 63327439
Nephroangiosclerosis 26.06 10.05 10 106870 156 63381986
Blue toe syndrome 25.95 10.05 13 106867 394 63381748
Knee arthroplasty 25.74 10.05 32 106848 54174 63327968
Gastrooesophageal reflux disease 25.66 10.05 260 106620 95379 63286763
Blister 25.46 10.05 122 106758 129692 63252450
Multiple drug therapy 25.35 10.05 31 106849 3615 63378527
Hip arthroplasty 24.93 10.05 26 106854 47620 63334522
Hyperlipidaemia 24.82 10.05 81 106799 19490 63362652
Rectal prolapse 24.73 10.05 23 106857 1960 63380182
Hypokinesia 24.71 10.05 65 106815 13871 63368271
Hypoacusis 24.62 10.05 93 106787 24058 63358084
Stent placement 24.62 10.05 31 106849 3724 63378418
Hyperkalaemia 24.61 10.05 166 106714 54037 63328105
Cerebrovascular accident 24.50 10.05 284 106596 107740 63274402
Respiration abnormal 24.49 10.05 41 106839 6376 63375766
Inflammation 24.36 10.05 65 106815 82208 63299934
Purpura 24.30 10.05 57 106823 11328 63370814
Fibrous histiocytoma 24.10 10.05 14 106866 573 63381569
Night sweats 24.04 10.05 28 106852 48786 63333356
Pyrexia 23.95 10.05 606 106274 469872 62912270
Cardiac pacemaker insertion 23.83 10.05 32 106848 4094 63378048
Coagulopathy 23.39 10.05 82 106798 20462 63361680
Device pacing issue 23.30 10.05 8 106872 89 63382053
Suicidal ideation 22.80 10.05 44 106836 62377 63319765
International normalised ratio increased 22.79 10.05 145 106735 46280 63335862
Presyncope 22.77 10.05 100 106780 27685 63354457
Sleep disorder due to general medical condition, insomnia type 22.59 10.05 33 106847 52184 63329958
Nasal congestion 22.41 10.05 188 106692 65472 63316670
Anal abscess 22.41 10.05 33 106847 4599 63377543
Gouty tophus 22.30 10.05 10 106870 235 63381907
Occult blood 22.11 10.05 18 106862 1283 63380859
Alanine aminotransferase increased 21.85 10.05 95 106785 103675 63278467
Supraventricular tachycardia 21.77 10.05 63 106817 14208 63367934
Respiratory rate increased 21.55 10.05 61 106819 13587 63368555
Drug resistance 21.44 10.05 6 106874 22927 63359215
Fibromyalgia 21.28 10.05 67 106813 80353 63301789
Total lung capacity decreased 21.05 10.05 22 106858 2161 63379981
Drug-induced liver injury 20.99 10.05 22 106858 40200 63341942
Heart rate irregular 20.95 10.05 84 106796 22337 63359805
Oral herpes 20.73 10.05 93 106787 25981 63356161
Aspartate aminotransferase increased 20.67 10.05 80 106800 90197 63291945
Haematuria 20.26 10.05 100 106780 29057 63353085
Joint injury 20.25 10.05 101 106779 29471 63352671
Product residue present 20.20 10.05 29 106851 3950 63378192
Premature baby 20.19 10.05 5 106875 20730 63361412
Drug hypersensitivity 19.85 10.05 386 106494 310301 63071841
Disturbance in attention 19.80 10.05 21 106859 38168 63343974
Ventricular arrhythmia 19.58 10.05 28 106852 3800 63378342
Unresponsive to stimuli 19.40 10.05 110 106770 33706 63348436
Hypoaesthesia oral 19.37 10.05 57 106823 12976 63369166
Blood pressure inadequately controlled 19.26 10.05 32 106848 4946 63377196
Sinus bradycardia 19.16 10.05 61 106819 14490 63367652
Injection site pruritus 19.04 10.05 29 106851 45087 63337055
Bone marrow failure 18.98 10.05 13 106867 29277 63352865
Peak expiratory flow rate abnormal 18.93 10.05 7 106873 98 63382044
Sinoatrial block 18.81 10.05 14 106866 874 63381268
Colon gangrene 18.79 10.05 4 106876 4 63382138
Tooth disorder 18.46 10.05 95 106785 28062 63354080
Cardioversion 18.45 10.05 16 106864 1244 63380898
Seasonal allergy 18.40 10.05 77 106803 20873 63361269
Myalgia 18.14 10.05 347 106533 146182 63235960
Product complaint 18.07 10.05 55 106825 12754 63369388
Haemoglobin decreased 17.83 10.05 344 106536 145141 63237001
Arrhythmogenic right ventricular dysplasia 17.71 10.05 5 106875 27 63382115
Weight abnormal 17.56 10.05 16 106864 1328 63380814
Renal pain 17.44 10.05 36 106844 6563 63375579
Fatigue 17.43 10.05 1274 105606 886754 62495388
Gastrointestinal procedural complication 17.42 10.05 8 106872 199 63381943
Electrocardiogram QT shortened 17.32 10.05 7 106873 126 63382016
Urticaria 17.26 10.05 187 106693 165615 63216527
Ventricular extrasystoles 17.26 10.05 51 106829 11636 63370506
Pain in extremity 17.25 10.05 702 106178 330784 63051358
Stupor 17.24 10.05 28 106852 4247 63377895
Calculus urinary 17.16 10.05 16 106864 1368 63380774
Live birth 17.12 10.05 11 106869 25619 63356523
Liver disorder 16.98 10.05 41 106839 53646 63328496
Gravitational oedema 16.94 10.05 15 106865 1199 63380943
Influenza 16.88 10.05 267 106613 108455 63273687
Patient elopement 16.86 10.05 5 106875 33 63382109
Cerebellar syndrome 16.81 10.05 25 106855 3514 63378628
Vomiting 16.71 10.05 771 106109 558846 62823296
Joint stiffness 16.64 10.05 28 106852 41841 63340301
Aortic arteriosclerosis 16.56 10.05 34 106846 6175 63375967
Medication error 16.43 10.05 147 106733 52137 63330005
Sputum purulent 16.32 10.05 14 106866 1073 63381069
Lower gastrointestinal haemorrhage 16.29 10.05 39 106841 7851 63374291
Coronary artery bypass 16.24 10.05 20 106860 2349 63379793
Status epilepticus 16.21 10.05 3 106877 15230 63366912
Malaise 16.08 10.05 855 106025 415099 62967043
Metastases to liver 15.99 10.05 10 106870 23629 63358513
Oxygen therapy 15.93 10.05 19 106861 2159 63379983
Catheter site erythema 15.89 10.05 27 106853 4249 63377893
Blood pressure diastolic decreased 15.86 10.05 78 106802 22628 63359514
Humidity intolerance 15.84 10.05 9 106871 353 63381789
Carbon dioxide increased 15.58 10.05 15 106865 1335 63380807
Electrocardiogram U wave present 15.55 10.05 6 106874 95 63382047
Nodal arrhythmia 15.50 10.05 14 106866 1149 63380993
Acute lung injury 15.45 10.05 16 106864 1555 63380587
Cytomegalovirus infection 15.41 10.05 8 106872 20944 63361198
Electrocardiogram QRS complex prolonged 15.23 10.05 32 106848 5906 63376236
Leukaemoid reaction 15.17 10.05 7 106873 176 63381966
Parotid gland enlargement 14.85 10.05 12 106868 846 63381296
Infusion site pain 14.81 10.05 62 106818 16807 63365335
Cardiac monitoring 14.77 10.05 4 106876 18 63382124
Confusional state 14.69 10.05 295 106585 236085 63146057
Anion gap abnormal 14.68 10.05 9 106871 407 63381735
Multiple sclerosis relapse 14.57 10.05 38 106842 48440 63333702
Dysuria 14.53 10.05 102 106778 33636 63348506
Pulmonary embolism 14.51 10.05 126 106754 116558 63265584
Chest discomfort 14.50 10.05 263 106617 109706 63272436
Catheter site haemorrhage 14.47 10.05 22 106858 3153 63378989
Catheterisation cardiac 14.45 10.05 27 106853 4576 63377566
Seizure 14.45 10.05 148 106732 132486 63249656
Haematemesis 14.32 10.05 94 106786 30318 63351824
Hypovolaemia 14.29 10.05 45 106835 10628 63371514
Premature delivery 14.24 10.05 18 106862 30263 63351879
Cardioactive drug level increased 14.16 10.05 18 106862 2182 63379960
Neutropenic sepsis 14.12 10.05 5 106875 16433 63365709
Nodule 14.08 10.05 9 106871 21017 63361125
Depressive symptom 14.07 10.05 25 106855 4077 63378065
Metastases to bone 14.07 10.05 9 106871 21010 63361132
Agranulocytosis 13.97 10.05 13 106867 25121 63357021
Abdominal distension 13.94 10.05 214 106666 86401 63295741
Injection site inflammation 13.93 10.05 24 106856 3819 63378323
Tympanic membrane perforation 13.89 10.05 17 106863 1984 63380158
Hypoventilation 13.84 10.05 27 106853 4727 63377415
Cataract 13.84 10.05 152 106728 56901 63325241
Catheter site discharge 13.81 10.05 17 106863 1996 63380146
Atrioventricular dissociation 13.77 10.05 7 106873 219 63381923
Electrocardiogram QT prolonged 13.71 10.05 157 106723 59373 63322769
Duodenal polyp 13.66 10.05 6 106874 134 63382008
Bundle branch block left 13.63 10.05 34 106846 7025 63375117
Drug dependence 13.62 10.05 79 106801 24404 63357738
Hypersensitivity 13.55 10.05 382 106498 292303 63089839
Vitamin D decreased 13.54 10.05 43 106837 10199 63371943
Rheumatoid nodule 13.50 10.05 61 106819 17094 63365048
Movement disorder 13.45 10.05 72 106808 21589 63360553
Cardiac valve disease 13.43 10.05 25 106855 4227 63377915
Depression 13.19 10.05 242 106638 196250 63185892
Bladder disorder 13.17 10.05 39 106841 8907 63373235
Haemarthrosis 13.15 10.05 21 106859 3140 63379002
Pruritus 13.10 10.05 487 106393 360966 63021176
Injection site swelling 13.03 10.05 39 106841 47533 63334609
Anaphylactic reaction 13.03 10.05 62 106818 66038 63316104
Blood loss anaemia 13.03 10.05 39 106841 8962 63373180
Orthopnoea 12.99 10.05 31 106849 6230 63375912
Sinus node dysfunction 12.90 10.05 26 106854 4659 63377483
Sopor 12.88 10.05 11 106869 22153 63359989
Product communication issue 12.83 10.05 10 106870 669 63381473
Appetite disorder 12.83 10.05 34 106846 7287 63374855
Epilepsy 12.82 10.05 16 106864 27049 63355093
Hypochromic anaemia 12.68 10.05 16 106864 1926 63380216
Chronic respiratory failure 12.65 10.05 16 106864 1931 63380211
Drug abuse 12.61 10.05 71 106809 72447 63309695
Respiratory acidosis 12.60 10.05 32 106848 6683 63375459
Injection site urticaria 12.58 10.05 4 106876 14069 63368073
Histoplasmosis 12.49 10.05 16 106864 1955 63380187
Oxygen consumption increased 12.47 10.05 23 106857 3861 63378281
Muscle spasticity 12.44 10.05 11 106869 21783 63360359
Skin necrosis 12.41 10.05 4 106876 13946 63368196
Product commingling 12.31 10.05 6 106874 171 63381971
Exercise tolerance decreased 12.26 10.05 28 106852 5469 63376673
Accidental exposure to product 12.17 10.05 17 106863 27388 63354754
Abdominal rigidity 12.16 10.05 16 106864 2008 63380134
Foot operation 12.09 10.05 33 106847 7198 63374944
Peritoneal haematoma 12.08 10.05 5 106875 96 63382046
Infusion site infection 12.06 10.05 15 106865 1779 63380363
Blood bilirubin increased 12.04 10.05 28 106852 37112 63345030
Wrist fracture 11.98 10.05 50 106830 13537 63368605
Infusion site erythema 11.93 10.05 45 106835 11634 63370508
Infusion site warmth 11.90 10.05 15 106865 1803 63380339
Long QT syndrome congenital 11.89 10.05 5 106875 100 63382042
Arrhythmia 11.86 10.05 107 106773 38033 63344109
Metabolic acidosis 11.83 10.05 122 106758 44947 63337195
Panic attack 11.75 10.05 71 106809 22260 63359882
Distributive shock 11.69 10.05 13 106867 1370 63380772
Mastication disorder 11.66 10.05 16 106864 2090 63380052
Stress 11.60 10.05 168 106712 66999 63315143
Nausea 11.58 10.05 1261 105619 853210 62528932
Gamma-glutamyltransferase increased 11.56 10.05 25 106855 34006 63348136
Bone density decreased 11.53 10.05 52 106828 14560 63367582
Angina unstable 11.48 10.05 32 106848 7063 63375079
Ventricular tachycardia 11.46 10.05 65 106815 19914 63362228
Coronary artery occlusion 11.39 10.05 35 106845 8156 63373986
Therapeutic response decreased 11.38 10.05 59 106821 61466 63320676
Psychotic disorder 11.37 10.05 16 106864 25696 63356446
Blood pressure systolic 11.30 10.05 4 106876 49 63382093
Metastases to central nervous system 11.23 10.05 4 106876 13101 63369041
Abdominal pain 11.16 10.05 393 106487 293063 63089079
Bursitis 11.16 10.05 29 106851 37012 63345130
Bronchial hyperreactivity 10.99 10.05 14 106866 1701 63380441
Inappropriate schedule of product administration 10.92 10.05 117 106763 103848 63278294
Intervertebral disc space narrowing 10.86 10.05 11 106869 1041 63381101
Heart rate abnormal 10.81 10.05 25 106855 4922 63377220
Chondrocalcinosis 10.79 10.05 10 106870 848 63381294
Prescribed underdose 10.78 10.05 21 106859 29668 63352474
Bone disorder 10.75 10.05 12 106868 21314 63360828
Muscle disorder 10.74 10.05 25 106855 4944 63377198
Aspiration pleural cavity 10.71 10.05 10 106870 857 63381285
Catheter site inflammation 10.69 10.05 10 106870 859 63381283
Atrial pressure increased 10.66 10.05 3 106877 16 63382126
Vasculitis 10.63 10.05 9 106871 18200 63363942
Mental disorder 10.61 10.05 17 106863 25902 63356240
Acute myeloid leukaemia 10.60 10.05 8 106872 17139 63365003
Aortic stenosis 10.57 10.05 25 106855 4995 63377147
Infusion site discharge 10.57 10.05 9 106871 683 63381459
Renal necrosis 10.57 10.05 4 106876 60 63382082
Spondyloarthropathy 10.51 10.05 10 106870 877 63381265
Reperfusion arrhythmia 10.50 10.05 6 106874 238 63381904
Caesarean section 10.46 10.05 8 106872 17024 63365118
Acute myocardial infarction 10.44 10.05 91 106789 32033 63350109
Premature labour 10.41 10.05 4 106876 12500 63369642
Incorrect dose administered 10.36 10.05 150 106730 59818 63322324
Infusion site haemorrhage 10.35 10.05 25 106855 5061 63377081
Brain hypoxia 10.23 10.05 8 106872 538 63381604
Cutaneous T-cell dyscrasia 10.22 10.05 4 106876 66 63382076
Reperfusion injury 10.16 10.05 4 106876 67 63382075
Bradyarrhythmia 10.13 10.05 15 106865 2100 63380042
Post procedural haemorrhage 10.13 10.05 33 106847 7931 63374211
Joint dislocation 10.13 10.05 10 106870 18790 63363352
Heavy menstrual bleeding 10.11 10.05 9 106871 17764 63364378
Polyneuropathy 10.11 10.05 6 106874 14583 63367559

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 257.61 10.77 503 52786 97665 34805977
Bradycardia 245.22 10.77 424 52865 74994 34828648
Atrial fibrillation 244.49 10.77 561 52728 121832 34781810
Cardiac failure congestive 147.98 10.77 365 52924 82905 34820737
Hypotension 123.47 10.77 664 52625 220985 34682657
Off label use 114.30 10.77 299 52990 419225 34484417
Dyspnoea 101.71 10.77 946 52343 375836 34527806
Mycotic allergy 93.03 10.77 35 53254 573 34903069
Conjunctivitis allergic 89.33 10.77 41 53248 1129 34902513
Mite allergy 88.15 10.77 35 53254 667 34902975
Spirometry abnormal 87.10 10.77 35 53254 689 34902953
Dust allergy 79.53 10.77 35 53254 871 34902771
Febrile neutropenia 64.57 10.77 68 53221 136781 34766861
Cardiac arrest 61.66 10.77 300 52989 95859 34807783
Suspected suicide 59.78 10.77 53 53236 4695 34898947
Myocardial infarction 59.43 10.77 351 52938 120734 34782908
General physical health deterioration 50.75 10.77 73 53216 128196 34775446
Chronic obstructive pulmonary disease 50.67 10.77 177 53112 48741 34854901
Neutropenia 50.32 10.77 102 53187 156676 34746966
Incision site pain 48.74 10.77 32 53257 1806 34901836
Drug interaction 44.05 10.77 532 52757 225414 34678228
Drug ineffective 43.65 10.77 466 52823 456285 34447357
Atrial flutter 43.41 10.77 82 53207 15492 34888150
Atrioventricular block complete 40.67 10.77 60 53229 9259 34894383
Cardiogenic shock 40.32 10.77 110 53179 26508 34877134
Coronary artery disease 39.44 10.77 162 53127 48143 34855499
Pyrexia 38.93 10.77 323 52966 332690 34570952
Dizziness 38.93 10.77 506 52783 218015 34685627
Productive cough 38.44 10.77 136 53153 37677 34865965
Cardioplegia 38.41 10.77 7 53282 0 34903642
Fluid retention 37.67 10.77 108 53181 26779 34876863
Atrioventricular block 36.76 10.77 53 53236 8010 34895632
Normochromic normocytic anaemia 35.44 10.77 38 53251 4249 34899393
BRASH syndrome 35.12 10.77 17 53272 529 34903113
Pulmonary arterial hypertension 34.91 10.77 54 53235 8685 34894957
Device dislocation 32.86 10.77 44 53245 6205 34897437
Oedema peripheral 32.65 10.77 302 52987 119510 34784132
Hypoxia 32.53 10.77 168 53121 54927 34848715
Full blood count abnormal 32.21 10.77 81 53208 18587 34885055
Biliary cirrhosis 30.53 10.77 10 53279 106 34903536
Arteriosclerosis coronary artery 30.27 10.77 62 53227 12423 34891219
Product use in unapproved indication 29.37 10.77 87 53202 117412 34786230
Wheezing 29.30 10.77 133 53156 41269 34862373
Foetal exposure during pregnancy 28.80 10.77 11 53278 38090 34865552
Red blood cells urine positive 28.55 10.77 23 53266 1786 34901856
Tetany 28.51 10.77 17 53272 809 34902833
Chest pain 28.01 10.77 306 52983 126456 34777186
Arterial spasm 27.68 10.77 9 53280 93 34903549
Antiacetylcholine receptor antibody positive 27.23 10.77 8 53281 57 34903585
Syncope 27.21 10.77 235 53054 91216 34812426
Pacemaker generated rhythm 26.64 10.77 8 53281 62 34903580
Atrioventricular block first degree 26.26 10.77 39 53250 6053 34897589
Embolic stroke 25.97 10.77 33 53256 4421 34899221
Subacute cutaneous lupus erythematosus 25.49 10.77 17 53272 985 34902657
Thrombocytopenia 24.96 10.77 138 53151 156109 34747533
Tooth injury 24.92 10.77 18 53271 1187 34902455
Angina pectoris 24.66 10.77 104 53185 31259 34872383
Neutrophil count decreased 24.52 10.77 25 53264 51079 34852563
Diaphragmatic disorder 24.01 10.77 18 53271 1257 34902385
Asthma 23.75 10.77 128 53161 42528 34861114
Cerebrovascular accident 23.20 10.77 214 53075 84597 34819045
Cardiac disorder 23.06 10.77 128 53161 42998 34860644
Prinzmetal angina 22.87 10.77 16 53273 1003 34902639
Angina unstable 22.71 10.77 53 53236 11600 34892042
Influenza virus test positive 22.28 10.77 8 53281 114 34903528
Nodule 21.66 10.77 38 53251 6781 34896861
Anal haemorrhage 21.57 10.77 23 53266 2555 34901087
Gallbladder polyp 21.48 10.77 11 53278 387 34903255
COVID-19 21.17 10.77 55 53234 77495 34826147
Gastrointestinal haemorrhage 21.13 10.77 217 53072 88260 34815382
Atrial thrombosis 20.77 10.77 21 53268 2193 34901449
Pancytopenia 20.63 10.77 75 53214 95082 34808560
International normalised ratio increased 20.53 10.77 133 53156 47194 34856448
Device malfunction 19.88 10.77 47 53242 10374 34893268
Rectal fissure 19.66 10.77 10 53279 347 34903295
Product use issue 19.51 10.77 42 53247 63174 34840468
Optic nerve operation 19.33 10.77 11 53278 479 34903163
Sleep disorder due to a general medical condition 19.11 10.77 31 53258 5190 34898452
Perineal infection 19.11 10.77 12 53277 627 34903015
Intentional product use issue 19.09 10.77 39 53250 59777 34843865
Protein urine present 19.08 10.77 31 53258 5197 34898445
Scrotal infection 18.87 10.77 12 53277 641 34903001
Heart rate irregular 18.85 10.77 60 53229 15747 34887895
Acquired haemophilia 18.45 10.77 14 53275 996 34902646
Mucosal inflammation 18.40 10.77 19 53270 38603 34865039
Chest discomfort 18.28 10.77 144 53145 54386 34849256
Toxic optic neuropathy 18.27 10.77 13 53276 837 34902805
Urinary tract discomfort 18.26 10.77 7 53282 121 34903521
Procedural pain 18.23 10.77 29 53260 4777 34898865
Chondrocalcinosis 18.17 10.77 10 53279 408 34903234
Malignant neoplasm progression 18.04 10.77 71 53218 87975 34815667
Nodal arrhythmia 17.89 10.77 13 53276 865 34902777
Sepsis 17.86 10.77 165 53124 166396 34737246
Distributive shock 17.82 10.77 15 53274 1239 34902403
Palpitations 17.73 10.77 113 53176 39873 34863769
Infected dermal cyst 17.68 10.77 13 53276 881 34902761
Rhythm idioventricular 17.62 10.77 9 53280 315 34903327
Heart rate decreased 17.49 10.77 95 53194 31650 34871992
Eczema infected 17.35 10.77 5 53284 33 34903609
Septic shock 16.66 10.77 55 53234 71779 34831863
Nocturia 16.27 10.77 43 53246 10167 34893475
Lymphocyte count decreased 16.24 10.77 73 53216 22549 34881093
Perineal pain 16.22 10.77 12 53277 821 34902821
Anticoagulation drug level above therapeutic 16.17 10.77 18 53271 2098 34901544
Eosinophilic pleural effusion 16.09 10.77 8 53281 264 34903378
White blood cell count decreased 15.95 10.77 83 53206 95362 34808280
Drug resistance 15.79 10.77 10 53279 25917 34877725
Arrhythmia 15.76 10.77 101 53188 35707 34867935
Arteriosclerosis 15.73 10.77 47 53242 11921 34891721
Product residue present 15.47 10.77 20 53269 2726 34900916
Oxygen saturation decreased 15.32 10.77 137 53152 53681 34849961
Arteriospasm coronary 15.08 10.77 22 53267 3360 34900282
Aortic stenosis 14.78 10.77 25 53264 4333 34899309
Pericardial haemorrhage 14.75 10.77 21 53268 3137 34900505
Angina bullosa haemorrhagica 14.71 10.77 5 53284 60 34903582
Medication error 14.42 10.77 77 53212 25488 34878154
Brugada syndrome 14.40 10.77 11 53278 790 34902852
Device capturing issue 14.39 10.77 3 53286 3 34903639
Pneumocystis jirovecii pneumonia 14.39 10.77 6 53283 19704 34883938
Discharge 14.22 10.77 8 53281 341 34903301
Mast cell degranulation present 14.14 10.77 5 53284 68 34903574
Tendon pain 14.11 10.77 20 53269 2975 34900667
Nodal rhythm 14.11 10.77 14 53275 1429 34902213
Hepatic function abnormal 14.09 10.77 29 53260 44334 34859308
Neuroleptic malignant syndrome 13.85 10.77 5 53284 17929 34885713
Shock 13.76 10.77 73 53216 24106 34879536
Mast cell activation syndrome 13.76 10.77 7 53282 243 34903399
Sleep apnoea syndrome 13.43 10.77 64 53225 20257 34883385
Agranulocytosis 13.42 10.77 10 53279 23811 34879831
Bronchopulmonary aspergillosis 13.33 10.77 3 53286 14656 34888986
Occupational exposure to air contaminants 13.32 10.77 6 53283 158 34903484
Arteriovenous fistula 13.19 10.77 12 53277 1099 34902543
Hypervolaemia 12.97 10.77 62 53227 19647 34883995
Psychotic disorder 12.86 10.77 11 53278 24441 34879201
Vitiligo 12.81 10.77 11 53278 933 34902709
Aggression 12.77 10.77 25 53264 38939 34864703
Labyrinthitis 12.69 10.77 11 53278 945 34902697
Alveolar osteitis 12.51 10.77 5 53284 97 34903545
Disease progression 12.49 10.77 105 53184 107972 34795670
Lower gastrointestinal haemorrhage 12.31 10.77 37 53252 9415 34894227
Inner ear disorder 12.15 10.77 6 53283 195 34903447
Respiratory acidosis 12.15 10.77 25 53264 5025 34898617
Injury 12.14 10.77 63 53226 20624 34883018
Intracranial aneurysm 12.09 10.77 14 53275 1704 34901938
Blood urine present 11.90 10.77 40 53249 10794 34892848
Coronary arterial stent insertion 11.83 10.77 22 53267 4107 34899535
Infectious mononucleosis 11.78 10.77 9 53280 647 34902995
Sedation 11.60 10.77 9 53280 20997 34882645
Hyperthyroidism 11.60 10.77 39 53250 10527 34893115
Transfusion 11.55 10.77 34 53255 8551 34895091
Suicidal ideation 11.52 10.77 28 53261 40360 34863282
Post streptococcal glomerulonephritis 11.45 10.77 5 53284 122 34903520
Ischaemic hepatitis 11.39 10.77 14 53275 1814 34901828
Vomiting 11.36 10.77 289 53000 247332 34656310
Hypokalaemia 11.26 10.77 137 53152 58077 34845565
Emotional distress 11.17 10.77 49 53240 14977 34888665
Renal injury 11.14 10.77 40 53249 11155 34892487
Oxygen consumption increased 11.10 10.77 12 53277 1354 34902288
Sports injury 11.09 10.77 5 53284 132 34903510
Right ventricular failure 11.08 10.77 34 53255 8750 34894892
Toxicity to various agents 11.07 10.77 391 52898 199971 34703671
Myelosuppression 10.97 10.77 8 53281 19257 34884385
Bulbar palsy 10.94 10.77 6 53283 243 34903399

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 701.16 9.65 1409 137488 244358 79361133
Sedation complication 591.16 9.65 358 138539 15311 79590180
Creatinine renal clearance decreased 554.29 9.65 369 138528 18633 79586858
Atrial fibrillation 545.57 9.65 1119 137778 196767 79408724
Hypotension 480.05 9.65 1769 137128 438548 79166943
Bradycardia 427.05 9.65 811 138086 134746 79470745
Orthostatic hypotension 402.73 9.65 493 138404 55671 79549820
Blood calcium decreased 371.24 9.65 361 138536 31458 79574033
Cardiac failure congestive 357.00 9.65 775 138122 141627 79463864
Balance disorder 336.99 9.65 612 138285 98245 79507246
Sedation 300.69 9.65 410 138487 51485 79554006
Off label use 297.70 9.65 719 138178 906496 78698995
Cognitive disorder 276.16 9.65 462 138435 69464 79536027
Depressed level of consciousness 215.22 9.65 502 138395 96150 79509341
Fall 195.49 9.65 1485 137412 486144 79119347
Dyspnoea 194.68 9.65 2312 136585 854713 78750778
Toxicity to various agents 194.49 9.65 1328 137569 420212 79185279
Drug ineffective 166.78 9.65 1152 137745 1079761 78525730
Febrile neutropenia 159.33 9.65 103 138794 230896 79374595
Neutropenia 156.60 9.65 162 138735 287548 79317943
Suspected suicide 152.36 9.65 135 138762 10441 79595050
Synovitis 141.92 9.65 43 138854 150691 79454800
Atrioventricular block complete 130.81 9.65 153 138744 16457 79589034
Maternal exposure during pregnancy 130.27 9.65 38 138859 136500 79468991
Systemic lupus erythematosus rash 115.47 9.65 59 138838 1801 79603690
Drug intolerance 105.87 9.65 186 138711 263933 79341558
Treatment failure 105.78 9.65 85 138812 170401 79435090
General physical health deterioration 104.84 9.65 200 138697 275038 79330453
Product use issue 103.38 9.65 128 138769 209694 79395797
Therapeutic product effect decreased 102.55 9.65 81 138816 163782 79441709
Urinary tract discomfort 102.09 9.65 41 138856 700 79604791
Dyspnoea exertional 97.03 9.65 353 138544 86720 79518771
Constipation 96.29 9.65 831 138066 282219 79323272
Fluid retention 96.29 9.65 304 138593 69505 79535986
Hand deformity 95.38 9.65 31 138866 103888 79501603
Chronic obstructive pulmonary disease 93.25 9.65 344 138553 85075 79520416
Pulmonary arterial hypertension 90.77 9.65 171 138726 28195 79577296
Arthropathy 90.48 9.65 105 138792 177006 79428485
Alveolar osteitis 90.28 9.65 39 138858 806 79604685
Nerve injury 90.26 9.65 96 138801 9296 79596195
Pemphigus 89.14 9.65 31 138866 99551 79505940
Mobility decreased 88.28 9.65 434 138463 121741 79483750
Pericarditis 82.65 9.65 39 138858 104197 79501294
Chest pain 81.43 9.65 800 138097 281504 79323987
Rheumatoid factor positive 81.13 9.65 6 138891 59833 79545658
BRASH syndrome 80.28 9.65 38 138859 979 79604512
Myocardial infarction 79.90 9.65 572 138325 183557 79421934
Heart rate increased 79.63 9.65 418 138479 120306 79485185
Exposure during pregnancy 78.41 9.65 39 138858 101093 79504398
Cardiac arrest 78.40 9.65 541 138356 171555 79433936
Joint swelling 78.33 9.65 250 138647 288396 79317095
Product use in unapproved indication 78.05 9.65 203 138694 250156 79355335
Atrial flutter 77.60 9.65 137 138760 21488 79584003
Rheumatoid arthritis 77.17 9.65 154 138743 208316 79397175
Full blood count abnormal 77.03 9.65 198 138699 40276 79565215
Nephrolithiasis 76.19 9.65 235 138662 53056 79552435
Anti-cyclic citrullinated peptide antibody positive 75.95 9.65 25 138872 83118 79522373
Alopecia 75.69 9.65 183 138714 231172 79374319
Tunnel vision 75.27 9.65 42 138855 1536 79603955
Asthma 74.65 9.65 446 138451 134649 79470842
Cardiogenic shock 74.62 9.65 200 138697 41714 79563777
Body tinea 74.16 9.65 44 138853 1810 79603681
Coronary artery disease 73.41 9.65 266 138631 65208 79540283
Hepatic enzyme increased 72.78 9.65 129 138768 182481 79423010
Bladder pain 72.06 9.65 47 138850 2290 79603201
Intentional product use issue 71.59 9.65 96 138801 152016 79453475
Respiratory tract congestion 71.07 9.65 126 138771 19828 79585663
Drug interaction 70.85 9.65 1065 137832 414118 79191373
Gastrointestinal haemorrhage 70.64 9.65 470 138427 147249 79458242
Inhibitory drug interaction 70.52 9.65 60 138837 4393 79601098
Spirometry abnormal 70.13 9.65 34 138863 925 79604566
Rash 70.00 9.65 657 138240 577701 79027790
Animal scratch 69.68 9.65 39 138858 1435 79604056
Conjunctivitis allergic 69.27 9.65 41 138856 1679 79603812
Infusion related reaction 69.25 9.65 190 138707 230047 79375444
Paranasal sinus discomfort 68.45 9.65 59 138838 4397 79601094
Atrioventricular block 68.14 9.65 102 138795 13939 79591552
Pericardial haemorrhage 68.00 9.65 59 138838 4436 79601055
Atrioventricular block second degree 67.21 9.65 73 138824 7239 79598252
Musculoskeletal stiffness 66.74 9.65 127 138770 174881 79430610
Labile blood pressure 66.28 9.65 44 138853 2209 79603282
Thrombocytopenia 65.01 9.65 240 138657 265019 79340472
Mite allergy 64.92 9.65 35 138862 1195 79604296
Angina pectoris 63.01 9.65 216 138681 51516 79553975
Hypoxia 62.35 9.65 349 138548 102894 79502597
Glossodynia 62.25 9.65 53 138844 103284 79502207
Malignant neoplasm progression 61.81 9.65 88 138809 135902 79469589
Wound 61.37 9.65 67 138830 116112 79489379
Pyrexia 61.22 9.65 824 138073 677885 78927606
Mycotic allergy 60.63 9.65 36 138861 1483 79604008
Ear congestion 60.41 9.65 46 138851 2873 79602618
Hunger 60.34 9.65 60 138837 5368 79600123
Dust allergy 60.26 9.65 36 138861 1500 79603991
C-reactive protein abnormal 59.85 9.65 7 138890 48360 79557131
Pancytopenia 58.32 9.65 126 138771 165619 79439872
Atrioventricular block first degree 58.15 9.65 89 138808 12402 79593089
Myopathy 57.34 9.65 117 138780 20446 79585045
Blood iron decreased 56.96 9.65 99 138798 15335 79590156
Neutrophil count decreased 56.83 9.65 48 138849 93911 79511580
Limb injury 56.75 9.65 145 138752 29383 79576108
Systemic lupus erythematosus 56.45 9.65 77 138820 121072 79484419
Pulmonary congestion 56.21 9.65 137 138760 26963 79578528
Bunion operation 55.65 9.65 29 138868 923 79604568
Discomfort 55.41 9.65 83 138814 125534 79479957
White blood cell count decreased 55.41 9.65 157 138740 188131 79417360
Nodal rhythm 55.38 9.65 45 138852 3090 79602401
Oedema peripheral 54.36 9.65 675 138222 251613 79353878
Contraindicated product administered 52.79 9.65 123 138774 157415 79448076
Duodenal ulcer perforation 52.13 9.65 25 138872 66186 79539305
Death 52.12 9.65 1323 137574 565191 79040300
Alveolitis 51.71 9.65 49 138848 4131 79601360
Infection susceptibility increased 50.64 9.65 46 138851 3675 79601816
Cerebrovascular accident 50.18 9.65 451 138446 154841 79450650
C-reactive protein increased 49.74 9.65 93 138804 128934 79476557
Wound complication 49.70 9.65 52 138845 4941 79600550
Stomatitis 49.64 9.65 114 138783 146643 79458848
Heart rate decreased 49.50 9.65 248 138649 70068 79535423
Mucosal inflammation 49 9.65 36 138861 75544 79529947
Incision site pain 48.68 9.65 40 138857 2790 79602701
Pain in jaw 47.15 9.65 182 138715 45969 79559522
Dizziness 46.82 9.65 1224 137673 525217 79080274
Palpitations 46.31 9.65 378 138519 126232 79479259
Productive cough 45.86 9.65 287 138610 88044 79517447
Cardiac disorder 44.94 9.65 230 138667 65527 79539964
Leukopenia 44.90 9.65 84 138813 116429 79489062
Polymyalgia rheumatica 44.71 9.65 47 138850 4490 79601001
Sinus pain 44.65 9.65 43 138854 3699 79601792
Rales 44.60 9.65 104 138793 19897 79585594
Poor quality sleep 44.11 9.65 112 138785 22610 79582881
Bronchopulmonary aspergillosis allergic 43.94 9.65 39 138858 3022 79602469
Syncope 43.43 9.65 491 138406 178958 79426533
Injection site erythema 42.52 9.65 44 138853 78153 79527338
Heart sounds 41.47 9.65 24 138873 942 79604549
Myelosuppression 40.71 9.65 10 138887 40286 79565205
Psoriatic arthropathy 40.07 9.65 46 138851 77953 79527538
Bronchitis 39.96 9.65 375 138522 130269 79475222
Unevaluable event 39.80 9.65 197 138700 55388 79550103
Disease progression 39.36 9.65 176 138721 184186 79421305
Obstructive airways disorder 38.87 9.65 132 138765 31327 79574164
Kidney infection 38.62 9.65 104 138793 21747 79583744
Blood urine present 38.28 9.65 102 138795 21195 79584296
Prolonged expiration 37.82 9.65 25 138872 1246 79604245
Blood pressure systolic increased 37.53 9.65 222 138675 66764 79538727
Bladder prolapse 37.20 9.65 26 138871 1421 79604070
Liver injury 36.65 9.65 27 138870 56587 79548904
Drug resistance 36.32 9.65 14 138883 42199 79563292
Foot deformity 36.13 9.65 108 138789 23966 79581525
Hepatic ischaemia 35.79 9.65 23 138874 1092 79604399
Hypervolaemia 35.47 9.65 158 138739 42532 79562959
Oxygen saturation decreased 35.35 9.65 362 138535 128685 79476806
Myocardial hypoxia 34.08 9.65 8 138889 16 79605475
Helicobacter infection 33.80 9.65 43 138854 69661 79535830
Cough 33.78 9.65 857 138040 365932 79239559
Vomiting 33.33 9.65 894 138003 664934 78940557
Torsade de pointes 33.22 9.65 91 138806 19221 79586270
Medication error 33.15 9.65 219 138678 68423 79537068
Glucose tolerance impaired 32.67 9.65 54 138843 8030 79597461
Feeling cold 32.43 9.65 117 138780 28612 79576879
Transfusion 32.30 9.65 96 138801 21234 79584257
Muscle relaxant therapy 32.18 9.65 12 138885 166 79605325
International normalised ratio increased 32.09 9.65 255 138642 84466 79521025
Nodal arrhythmia 32.04 9.65 27 138870 1951 79603540
Cardioplegia 31.71 9.65 7 138890 9 79605482
Pulmonary hypertension 30.67 9.65 165 138732 47915 79557576
Angina unstable 30.57 9.65 80 138817 16447 79589044
Erythrodermic psoriasis 30.56 9.65 25 138872 1733 79603758
COVID-19 30.45 9.65 156 138741 157518 79447973
Wound secretion 30.09 9.65 45 138852 6143 79599348
Agranulocytosis 29.77 9.65 21 138876 45009 79560482
Red blood cell sedimentation rate increased 29.63 9.65 22 138875 45920 79559571
Swollen joint count increased 29.17 9.65 3 138894 22924 79582567
Prinzmetal angina 28.94 9.65 24 138873 1696 79603795
Forced expiratory volume decreased 28.68 9.65 50 138847 7764 79597727
Embolic stroke 28.62 9.65 50 138847 7776 79597715
Ill-defined disorder 28.59 9.65 44 138853 65831 79539660
Alanine aminotransferase increased 28.56 9.65 166 138731 162404 79443087
Arthralgia 28.53 9.65 768 138129 571035 79034456
Abortion spontaneous 28.52 9.65 8 138889 29499 79575992
Oedema 28.38 9.65 326 138571 119254 79486237
Sebaceous gland infection 28.33 9.65 11 138886 171 79605320
Aspartate aminotransferase increased 28.02 9.65 135 138762 138506 79466985
Status epilepticus 27.79 9.65 5 138892 25036 79580455
Skin laceration 27.79 9.65 112 138785 28850 79576641
Inflammation 27.69 9.65 78 138819 93675 79511816
Abdominal pain 27.55 9.65 495 138402 389074 79216417
Intentional self-injury 27.48 9.65 11 138886 32408 79573083
Platelet count decreased 27.10 9.65 213 138684 194451 79411040
Cardiac ablation 27.09 9.65 26 138871 2227 79603264
Pulmonary oedema 26.82 9.65 253 138644 88001 79517490
Distributive shock 26.77 9.65 28 138869 2659 79602832
Pregnancy 26.48 9.65 7 138890 26844 79578647
Septic shock 26.34 9.65 117 138780 122684 79482807
Therapeutic product effect incomplete 26.31 9.65 142 138755 141503 79463988
Sinus bradycardia 26.14 9.65 100 138797 25147 79580344
Tooth infection 25.94 9.65 82 138815 18750 79586741
Bronchopulmonary aspergillosis 25.74 9.65 4 138893 22290 79583201
Heart rate irregular 25.69 9.65 119 138778 32560 79572931
Rheumatic fever 25.31 9.65 9 138888 28516 79576975
Gastrointestinal disorder 25.28 9.65 118 138779 122087 79483404
Pacemaker generated rhythm 25.26 9.65 8 138889 65 79605426
Pneumonia 25.23 9.65 1398 137499 658848 78946643
Thermal burn 25.22 9.65 45 138852 7115 79598376
Supraventricular tachycardia 25.19 9.65 88 138809 21182 79584309
Hyperkalaemia 25.00 9.65 307 138590 114091 79491400
Condition aggravated 25.00 9.65 673 138224 500451 79105040
Aortic stenosis 25.00 9.65 46 138851 7449 79598042
Folliculitis 24.99 9.65 36 138861 55344 79550147
Bezoar 24.99 9.65 27 138870 2661 79602830
Disturbance in attention 24.98 9.65 31 138866 50770 79554721
Neutropenic sepsis 24.96 9.65 8 138889 27056 79578435
Sinus disorder 24.95 9.65 91 138806 22373 79583118
Chondrocalcinosis 24.90 9.65 18 138879 1038 79604453
Antiacetylcholine receptor antibody positive 24.84 9.65 8 138889 69 79605422
Biliary cirrhosis 24.78 9.65 10 138887 173 79605318
Liver disorder 24.68 9.65 56 138841 72361 79533130
Nasal polyps 24.47 9.65 45 138852 7282 79598209
Cellulitis 24.41 9.65 294 138603 108766 79496725
Rectal prolapse 24.07 9.65 24 138873 2154 79603337
Lower gastrointestinal haemorrhage 23.87 9.65 72 138825 16053 79589438
Hepatic function abnormal 23.74 9.65 58 138839 73049 79532442
Suicidal ideation 23.68 9.65 62 138835 76278 79529213
Respiratory acidosis 23.63 9.65 57 138840 11143 79594348
Blue toe syndrome 23.57 9.65 14 138883 577 79604914
Nasal congestion 23.53 9.65 220 138677 76332 79529159
Fibrous histiocytoma 23.50 9.65 15 138882 704 79604787
Muscle injury 23.50 9.65 30 138867 48531 79556960
Erythromelalgia 23.45 9.65 10 138887 200 79605291
Arteriospasm coronary 23.39 9.65 42 138855 6674 79598817
Allergy to venom 23.32 9.65 5 138892 5 79605486
Bone marrow failure 23.28 9.65 33 138864 51074 79554417
Cytomegalovirus infection 23.17 9.65 24 138873 42620 79562871
Atrial thrombosis 22.87 9.65 30 138867 3626 79601865
Hyperlipidaemia 22.76 9.65 98 138799 25995 79579496
Injection site pruritus 22.75 9.65 24 138873 42259 79563232
Abdominal discomfort 22.65 9.65 304 138593 250423 79355068
Nausea 22.57 9.65 1402 137495 955794 78649697
Coronary artery bypass 22.52 9.65 39 138858 6023 79599468
Gastrooesophageal reflux disease 22.45 9.65 279 138618 103967 79501524
Sopor 22.35 9.65 15 138882 32995 79572496
Arterial spasm 22.34 9.65 9 138888 155 79605336
Arteriosclerosis coronary artery 22.23 9.65 75 138822 17741 79587750
Incision site haemorrhage 22.22 9.65 17 138880 1069 79604422
Coagulopathy 21.91 9.65 122 138775 35884 79569607
Arteriovenous fistula occlusion 21.82 9.65 13 138884 539 79604952
Multiple drug therapy 21.78 9.65 31 138866 4047 79601444
Psychotic disorder 21.72 9.65 24 138873 41378 79564113
Pneumocystis jirovecii pneumonia 21.70 9.65 15 138882 32493 79572998
Electrocardiogram QRS complex prolonged 21.65 9.65 54 138843 10779 79594712
Arrhythmogenic right ventricular dysplasia 21.43 9.65 6 138891 30 79605461
Arrhythmia 21.36 9.65 181 138716 61091 79544400
Impaired quality of life 21.08 9.65 64 138833 14322 79591169
Blood pressure diastolic decreased 20.86 9.65 106 138791 30110 79575381
Neuroleptic malignant syndrome 20.80 9.65 11 138886 27548 79577943
Chest discomfort 20.78 9.65 347 138550 137697 79467794
Sepsis 20.76 9.65 337 138560 269091 79336400
Diaphragmatic disorder 20.67 9.65 20 138877 1730 79603761
Tendon pain 20.50 9.65 36 138861 5622 79599869
Bronchiectasis 20.24 9.65 85 138812 22301 79583190
Drug hypersensitivity 20.12 9.65 383 138514 298533 79306958
Blood loss anaemia 20.01 9.65 66 138831 15432 79590059
Gravitational oedema 19.84 9.65 20 138877 1819 79603672
Pollakiuria 19.83 9.65 122 138775 37195 79568296
Irritable bowel syndrome 19.73 9.65 50 138847 62191 79543300
Cardiac failure 19.69 9.65 379 138518 154463 79451028
Acute myeloid leukaemia 19.64 9.65 15 138882 30870 79574621
Inappropriate schedule of product administration 19.64 9.65 144 138753 133484 79472007
Osteonecrosis of jaw 19.60 9.65 28 138869 43198 79562293
Aggression 19.39 9.65 37 138860 50921 79554570
Wrong technique in product usage process 19.30 9.65 65 138832 73810 79531681
Haemophagocytic lymphohistiocytosis 19.19 9.65 7 138890 21830 79583661
Respiration abnormal 19.04 9.65 42 138855 7746 79597745
Epilepsy 19.00 9.65 26 138871 40834 79564657
Hypoacusis 18.91 9.65 103 138794 30047 79575444
Asthenia 18.84 9.65 1080 137817 510609 79094882
Atrioventricular dissociation 18.69 9.65 10 138887 336 79605155
Peak expiratory flow rate abnormal 18.63 9.65 7 138890 99 79605392
Nephroangiosclerosis 18.61 9.65 10 138887 339 79605152
Incorrect route of product administration 18.60 9.65 20 138877 34909 79570582
Haemarthrosis 18.54 9.65 35 138862 5777 79599714
Bradyarrhythmia 18.54 9.65 29 138868 4117 79601374
Cardiac pacemaker insertion 18.50 9.65 35 138862 5787 79599704
Oxygen consumption increased 18.45 9.65 32 138865 4947 79600544
Umbilical hernia 18.40 9.65 35 138862 5810 79599681
Hyperbilirubinaemia 18.19 9.65 10 138887 24508 79580983
Blood bilirubin increased 18.19 9.65 57 138840 66175 79539316
Abnormal behaviour 18.15 9.65 22 138875 36399 79569092
Scrotal infection 18.10 9.65 12 138885 601 79604890
Gamma-glutamyltransferase increased 18.06 9.65 43 138854 54637 79550854
Presyncope 18.05 9.65 128 138769 40926 79564565
Optic nerve operation 17.97 9.65 11 138886 479 79605012
Urticaria 17.66 9.65 222 138675 184979 79420512
Neoplasm progression 17.58 9.65 40 138857 51642 79553849
Hip arthroplasty 17.39 9.65 22 138875 35734 79569757
Aortic arteriosclerosis 17.35 9.65 44 138853 8874 79596617
Schizophrenia 17.32 9.65 3 138894 15437 79590054
Renal pain 17.27 9.65 42 138855 8254 79597237
Hepatotoxicity 17.26 9.65 40 138857 51312 79554179
Anaphylactic reaction 17.23 9.65 81 138816 83662 79521829
Vasoplegia syndrome 17.09 9.65 26 138871 3604 79601887
Aspergillus infection 17.08 9.65 6 138891 19155 79586336
Normochromic normocytic anaemia 17.03 9.65 40 138857 7687 79597804
Gingival hypertrophy 16.95 9.65 24 138873 3118 79602373
Bone erosion 16.95 9.65 5 138892 17842 79587649
Renal injury 16.67 9.65 66 138831 16861 79588630
Metastases to bone 16.67 9.65 11 138886 24416 79581075
Multiple sclerosis relapse 16.67 9.65 35 138862 46498 79558993
Weight abnormal 16.65 9.65 17 138880 1569 79603922
Gouty tophus 16.60 9.65 10 138887 423 79605068
Carbon dioxide increased 16.59 9.65 20 138877 2220 79603271
Renal failure 16.58 9.65 463 138434 200505 79404986
Ventricular arrhythmia 16.56 9.65 43 138854 8797 79596694
Intracranial aneurysm 16.55 9.65 29 138868 4521 79600970
Dysphagia 16.36 9.65 135 138762 122001 79483490
Heart rate abnormal 16.34 9.65 34 138863 6023 79599468
Polyneuropathy 16.31 9.65 11 138886 24140 79581351
Therapy partial responder 16.30 9.65 5 138892 17392 79588099
Pulseless electrical activity 16.26 9.65 58 138839 14102 79591389
Sleep disorder due to general medical condition, insomnia type 16.25 9.65 32 138865 43524 79561967
Tooth disorder 16.04 9.65 89 138808 26144 79579347
Oral herpes 16.03 9.65 92 138805 27362 79578129
Red blood cells urine positive 15.98 9.65 30 138867 4933 79600558
Procedural pain 15.95 9.65 81 138816 23003 79582488
Myocardial ischaemia 15.88 9.65 87 138810 25432 79580059
Acute lung injury 15.73 9.65 23 138874 3077 79602414
Cytokine release syndrome 15.66 9.65 24 138873 35974 79569517
Night sweats 15.64 9.65 43 138854 52052 79553439
Disseminated intravascular coagulation 15.49 9.65 24 138873 35818 79569673
Hypokinesia 15.42 9.65 70 138827 18990 79586501
Muscle strain 15.42 9.65 44 138853 9511 79595980
Hospitalisation 15.34 9.65 240 138657 93996 79511495
Catheter site haemorrhage 15.33 9.65 30 138867 5087 79600404
Wheezing 15.32 9.65 287 138610 116377 79489114
Aplastic anaemia 15.30 9.65 6 138891 17899 79587592
Interstitial lung disease 15.29 9.65 124 138773 112476 79493015
Cardioactive drug level increased 15.29 9.65 25 138872 3684 79601807
Foot operation 15.25 9.65 32 138865 5701 79599790
Toxic optic neuropathy 15.19 9.65 14 138883 1139 79604352
Pulmonary function test decreased 15.19 9.65 38 138859 7599 79597892
Perineal infection 15.14 9.65 12 138885 795 79604696
Joint injury 15.14 9.65 100 138797 31235 79574256
Sinoatrial block 15.14 9.65 15 138882 1336 79604155
Gallbladder polyp 14.99 9.65 13 138884 977 79604514
Immune reconstitution inflammatory syndrome 14.86 9.65 3 138894 13838 79591653
Tooth injury 14.85 9.65 18 138879 2010 79603481
Catheter site erythema 14.83 9.65 30 138867 5210 79600281
Hypoaesthesia oral 14.67 9.65 56 138841 14068 79591423
Stent placement 14.64 9.65 34 138863 6486 79599005
Aspiration pleural cavity 14.61 9.65 16 138881 1601 79603890
Seizure 14.60 9.65 236 138661 188598 79416893
Humidity intolerance 14.58 9.65 9 138888 398 79605093
Drug reaction with eosinophilia and systemic symptoms 14.51 9.65 60 138837 64184 79541307
Cardioversion 14.36 9.65 18 138879 2080 79603411
Sleep disorder due to a general medical condition 14.33 9.65 56 138841 14221 79591270
Restlessness 14.24 9.65 38 138859 46454 79559037
Hyperglycaemia 14.19 9.65 186 138711 70149 79535342
Anal haemorrhage 14.14 9.65 26 138871 4208 79601283
Cardiac valve disease 14.08 9.65 31 138866 5710 79599781
Hepatorenal syndrome 14.07 9.65 26 138871 4223 79601268
Vitamin D decreased 14 9.65 43 138854 9682 79595809
Skin necrosis 13.98 9.65 7 138890 18080 79587411
Fibromyalgia 13.97 9.65 61 138836 64279 79541212
Brain oedema 13.97 9.65 14 138883 25249 79580242
Sinus node dysfunction 13.96 9.65 37 138860 7664 79597827
Wrist fracture 13.84 9.65 49 138848 11872 79593619
Gastrointestinal procedural complication 13.75 9.65 7 138890 212 79605279
Rash pruritic 13.75 9.65 71 138826 71558 79533933
Coronary artery occlusion 13.73 9.65 58 138839 15257 79590234
Tympanic membrane perforation 13.73 9.65 16 138881 1714 79603777
Electrocardiogram U wave present 13.67 9.65 6 138891 129 79605362
Bursitis 13.66 9.65 26 138871 35818 79569673
Lymphopenia 13.65 9.65 20 138877 30537 79574954
Tenosynovitis 13.64 9.65 5 138892 15549 79589942
Blood pressure inadequately controlled 13.64 9.65 32 138865 6145 79599346
Device pacing issue 13.63 9.65 6 138891 130 79605361
Joint stiffness 13.57 9.65 32 138865 40798 79564693
Ureteric obstruction 13.57 9.65 20 138877 2696 79602795
Electrocardiogram QT shortened 13.51 9.65 7 138890 220 79605271
Weight decreased 13.50 9.65 752 138145 354446 79251045
Myalgia 13.49 9.65 421 138476 185220 79420271
Mast cell degranulation present 13.49 9.65 5 138892 68 79605423
Deep vein thrombosis 13.46 9.65 140 138757 120779 79484712
Eosinophilic pleural effusion 13.44 9.65 8 138889 331 79605160
Drug abuse 13.36 9.65 201 138696 162490 79443001
Patient elopement 13.36 9.65 5 138892 70 79605421
Arteriosclerosis 13.33 9.65 65 138832 18162 79587329
Musculoskeletal pain 13.32 9.65 114 138783 102240 79503251
Cytomegalovirus viraemia 13.31 9.65 3 138894 12818 79592673
Shock 13.30 9.65 125 138772 43423 79562068
Rhythm idioventricular 13.28 9.65 10 138887 614 79604877
Device malfunction 13.27 9.65 73 138824 21375 79584116
Myocarditis 13.26 9.65 11 138886 21722 79583769
Progressive multifocal leukoencephalopathy 13.11 9.65 10 138887 20590 79584901
Muscle disorder 13.08 9.65 30 138867 5677 79599814
Coronary arterial stent insertion 13.01 9.65 31 138866 6013 79599478
Eczema infected 12.98 9.65 5 138892 76 79605415
Erythema 12.98 9.65 293 138604 222997 79382494
Pain in extremity 12.93 9.65 767 138130 363771 79241720
Parotid gland enlargement 12.92 9.65 12 138885 986 79604505
Blood cholesterol increased 12.89 9.65 89 138808 83631 79521860
Anion gap abnormal 12.88 9.65 10 138887 643 79604848
Pruritus 12.88 9.65 559 138338 394089 79211402
Hypercalcaemia 12.87 9.65 30 138867 38400 79567091
Influenza virus test positive 12.84 9.65 8 138889 360 79605131
Colon gangrene 12.80 9.65 4 138893 31 79605460
Injection site inflammation 12.76 9.65 24 138873 3952 79601539
Anuria 12.73 9.65 71 138826 20892 79584599
Histoplasmosis 12.66 9.65 18 138879 2347 79603144
Palmar-plantar erythrodysaesthesia syndrome 12.66 9.65 24 138873 33110 79572381
Mental disorder 12.56 9.65 22 138875 31280 79574211
Occupational exposure to air contaminants 12.55 9.65 6 138891 158 79605333
Nocturia 12.41 9.65 52 138845 13629 79591862
Catheter site discharge 12.39 9.65 18 138879 2394 79603097
Ankylosing spondylitis 12.39 9.65 3 138894 12202 79593289
Infected dermal cyst 12.34 9.65 13 138884 1245 79604246
Ascites 12.30 9.65 79 138818 75483 79530008
Sleep disorder 12.26 9.65 93 138804 85584 79519907
Protein urine present 12.12 9.65 42 138855 10070 79595421
Appendicitis 12.11 9.65 11 138886 20783 79584708
Perineal pain 12.10 9.65 12 138885 1070 79604421
Tetany 12.09 9.65 19 138878 2709 79602782
Blood pressure increased 12.02 9.65 466 138431 210894 79394597
Right ventricular failure 11.97 9.65 76 138821 23421 79582070
Posterior reversible encephalopathy syndrome 11.94 9.65 17 138880 26264 79579227
Infection 11.92 9.65 325 138572 241387 79364104
Peritonitis 11.90 9.65 19 138878 28017 79577474
Transaminases increased 11.89 9.65 48 138849 51695 79553796
Drug-induced liver injury 11.88 9.65 67 138830 66050 79539441
Altered state of consciousness 11.83 9.65 38 138859 43784 79561707
COVID-19 pneumonia 11.83 9.65 20 138877 28829 79576662
Purpura 11.77 9.65 66 138831 19461 79586030
Coronary artery restenosis 11.75 9.65 13 138884 1316 79604175
Febrile bone marrow aplasia 11.74 9.65 4 138893 13016 79592475
Metastases to central nervous system 11.69 9.65 7 138890 16368 79589123
Seasonal allergy 11.64 9.65 58 138839 16348 79589143
Cytopenia 11.62 9.65 11 138886 20372 79585119
Catheter management 11.61 9.65 22 138875 3641 79601850
Arteriovenous fistula 11.55 9.65 13 138884 1341 79604150
Enlarged uvula 11.53 9.65 8 138889 432 79605059
Post procedural haemorrhage 11.51 9.65 51 138846 13693 79591798
Injection site urticaria 11.46 9.65 4 138893 12822 79592669
Stupor 11.44 9.65 32 138865 6840 79598651
Ectopic ACTH syndrome 11.43 9.65 6 138891 194 79605297
Cholangitis 11.39 9.65 4 138893 12772 79592719
Mitral valve incompetence 11.38 9.65 87 138810 28478 79577013
Influenza 11.36 9.65 301 138596 129305 79476186
Anaphylactic shock 11.34 9.65 29 138868 35967 79569524
Knee arthroplasty 11.33 9.65 38 138859 43210 79562281
Metastases to lung 11.32 9.65 9 138888 18154 79587337
Rheumatoid nodule 11.22 9.65 60 138837 17378 79588113
Generalised tonic-clonic seizure 11.22 9.65 39 138858 43871 79561620
Peritoneal haematoma 11.12 9.65 6 138891 205 79605286
Infusion site erythema 11.08 9.65 39 138858 9421 79596070
Intentional product misuse 11.08 9.65 109 138788 95056 79510435
Extrapyramidal disorder 10.98 9.65 14 138883 22665 79582826
Hepatic cytolysis 10.97 9.65 19 138878 27132 79578359
Appetite disorder 10.94 9.65 34 138863 7705 79597786
Miosis 10.92 9.65 7 138890 15782 79589709
Catheter site pain 10.89 9.65 27 138870 5369 79600122
Serotonin syndrome 10.84 9.65 41 138856 44986 79560505
Rectal haemorrhage 10.82 9.65 190 138707 76110 79529381
Hyperthyroidism 10.80 9.65 71 138826 22138 79583353
Neuropathy peripheral 10.79 9.65 177 138720 141128 79464363
Bone density decreased 10.79 9.65 49 138848 13298 79592193
Calculus urinary 10.71 9.65 17 138880 2443 79603048
Muscle spasticity 10.67 9.65 13 138884 21462 79584029
Post streptococcal glomerulonephritis 10.66 9.65 5 138892 126 79605365
Bundle branch block left 10.63 9.65 44 138853 11469 79594022
Leukaemoid reaction 10.59 9.65 7 138890 349 79605142
Sinus arrest 10.56 9.65 21 138876 3601 79601890
Depression 10.56 9.65 292 138605 216498 79388993
Fear 10.52 9.65 70 138827 21916 79583575
Orthopnoea 10.51 9.65 40 138857 10033 79595458
Diffuse large B-cell lymphoma 10.50 9.65 4 138893 12145 79593346
Lip dry 10.44 9.65 7 138890 15411 79590080
Oxygen therapy 10.43 9.65 18 138879 2772 79602719
Aphasia 10.34 9.65 44 138853 46688 79558803
Dilatation atrial 10.24 9.65 21 138876 3683 79601808
Cardiac flutter 10.22 9.65 25 138872 4929 79600562
Coma 10.22 9.65 119 138778 100530 79504961
Skin swelling 10.21 9.65 22 138875 3992 79601499
Jaundice 10.17 9.65 53 138844 53296 79552195
Cutaneous T-cell dyscrasia 10.09 9.65 4 138893 66 79605425
Accidental exposure to product 10.05 9.65 25 138872 31297 79574194
Pulmonary embolism 10.04 9.65 225 138672 171429 79434062
Blister 10.02 9.65 147 138750 119329 79486162
Creatinine renal clearance increased 9.98 9.65 10 138887 903 79604588
Paracentesis 9.95 9.65 12 138885 1333 79604158
Campylobacter test positive 9.92 9.65 4 138893 69 79605422
Asphyxia 9.90 9.65 4 138893 11716 79593775
Infective pulmonary exacerbation of cystic fibrosis 9.89 9.65 5 138892 12846 79592645
Respiratory rate increased 9.88 9.65 68 138829 21532 79583959
Motion sickness 9.87 9.65 10 138887 915 79604576
Obesity 9.81 9.65 30 138867 35095 79570396
Long QT syndrome congenital 9.80 9.65 5 138892 152 79605339
Hepatitis 9.73 9.65 57 138840 55670 79549821
Immune thrombocytopenia 9.70 9.65 10 138887 17795 79587696
Uveitis 9.69 9.65 9 138888 16821 79588670
Live birth 9.68 9.65 11 138886 18733 79586758
Bulbar palsy 9.67 9.65 6 138891 268 79605223

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C05AE03 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Muscle relaxants
ATC C08DB01 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS
Benzothiazepine derivatives
FDA MoA N0000000069 Calcium Channel Antagonists
FDA EPC N0000175566 Calcium Channel Blocker
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D014665 Vasodilator Agents
FDA MoA N0000182141 Cytochrome P450 3A4 Inhibitors
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:38215 calcium channel blockers

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Atrial fibrillation indication 49436004 DOID:0060224
Paroxysmal supraventricular tachycardia indication 67198005
Prinzmetal angina indication 87343002
Angina pectoris indication 194828000
Anal fissure off-label use 30037006
Supraventricular arrhythmia off-label use 72654001
Diastolic heart failure off-label use 418304008 DOID:9775
Hyperkalemia contraindication 14140009
Ventricular tachycardia contraindication 25569003
Complete atrioventricular block contraindication 27885002
Acute cerebrovascular insufficiency contraindication 29322000
Sick sinus syndrome contraindication 36083008 DOID:13884
Immunosuppression contraindication 38013005
Angioedema contraindication 41291007 DOID:1558
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Lown-Ganong-Levine syndrome contraindication 55475008 DOID:13087
Aortic valve stenosis contraindication 60573004 DOID:1712
Wolff-Parkinson-White pattern contraindication 74390002 DOID:384
Transplantation contraindication 77465005
Chronic idiopathic constipation contraindication 82934008
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Disorder of connective tissue contraindication 105969002 DOID:65
Second degree atrioventricular block contraindication 195042002
Decompensated cardiac failure contraindication 195111005
Hypertrophic cardiomyopathy contraindication 233873004 DOID:11984
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Left ventricular cardiac dysfunction contraindication 429589006
Hemodialysis with High-Flux Membrane contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.63 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel BLOCKER IC50 7.32 WOMBAT-PK CHEMBL
Cytochrome P450 3A4 Enzyme IC50 5.74 DRUG MATRIX
Multidrug resistance protein 1 Transporter IC50 4.37 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 5.62 PDSP
5-hydroxytryptamine receptor 3A Ion channel BLOCKER IC50 4.68 IUPHAR
Voltage-dependent calcium channel gamma-1 subunit Ion channel IC50 6.10 WOMBAT-PK
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel Ki 4.02 WOMBAT-PK
Voltage-dependent L-type calcium channel subunit alpha-1S Ion channel Ki 6.42 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.91 CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 4.35 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 4.76 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel IC50 4.52 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel IC50 7.27 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1D Ion channel IC50 7.34 CHEMBL
5-hydroxytryptamine receptor 3A Ion channel BLOCKER IC50 5.26 IUPHAR
Voltage-gated L-type calcium channel Ion channel Ki 7.80 CHEMBL
Potassium voltage-gated channel subfamily C member 1 Ion channel BLOCKER IC50 4 IUPHAR
Potassium voltage-gated channel subfamily A member 7 Ion channel BLOCKER IC50 4.20 IUPHAR
Voltage-dependent L-type calcium channel subunit alpha-1F Ion channel BLOCKER IC50 4 IUPHAR

External reference:

IDSource
4020128 VUID
N0000179650 NUI
D00616 KEGG_DRUG
33286-22-5 SECONDARY_CAS_RN
144604-00-2 SECONDARY_CAS_RN
203211 RXNORM
4018817 VANDF
4019722 VANDF
4020128 VANDF
CHEBI:101278 CHEBI
C9F PDB_CHEM_ID
CHEMBL23 ChEMBL_ID
CHEMBL1697 ChEMBL_ID
2298 IUPHAR_LIGAND_ID
3433 INN_ID
DB00343 DRUGBANK_ID
EE92BBP03H UNII
1547 MMSL
4604 MMSL
d00045 MMSL
000711 NDDF
004514 NDDF
007237 NDDF
12218006 SNOMEDCT_US
372793000 SNOMEDCT_US
59941008 SNOMEDCT_US
C0012373 UMLSCUI
D004110 MESH_DESCRIPTOR_UI
CHEMBL1200805 ChEMBL_ID
39186 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Diltiazem Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0318 TABLET, FILM COATED 30 mg ORAL ANDA 18 sections
Diltiazem Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0319 TABLET, FILM COATED 60 mg ORAL ANDA 18 sections
Diltiazem Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0320 TABLET, FILM COATED 90 mg ORAL ANDA 18 sections
Diltiazem Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0321 TABLET, FILM COATED 120 mg ORAL ANDA 18 sections
Cardizem HUMAN PRESCRIPTION DRUG LABEL 1 0187-0771 TABLET, COATED 30 mg ORAL NDA 21 sections
Cardizem HUMAN PRESCRIPTION DRUG LABEL 1 0187-0772 TABLET, COATED 60 mg ORAL NDA 21 sections
Cardizem HUMAN PRESCRIPTION DRUG LABEL 1 0187-0791 TABLET, COATED 90 mg ORAL NDA 21 sections
Cardizem HUMAN PRESCRIPTION DRUG LABEL 1 0187-0792 TABLET, COATED 120 mg ORAL NDA 21 sections
Cardizem CD HUMAN PRESCRIPTION DRUG LABEL 1 0187-0795 CAPSULE, COATED, EXTENDED RELEASE 120 mg ORAL NDA 14 sections
Cardizem CD HUMAN PRESCRIPTION DRUG LABEL 1 0187-0796 CAPSULE, COATED, EXTENDED RELEASE 180 mg ORAL NDA 14 sections
Cardizem CD HUMAN PRESCRIPTION DRUG LABEL 1 0187-0797 CAPSULE, COATED, EXTENDED RELEASE 240 mg ORAL NDA 14 sections
Cardizem CD HUMAN PRESCRIPTION DRUG LABEL 1 0187-0798 CAPSULE, COATED, EXTENDED RELEASE 300 mg ORAL NDA 14 sections
Cardizem CD HUMAN PRESCRIPTION DRUG LABEL 1 0187-0799 CAPSULE, COATED, EXTENDED RELEASE 360 mg ORAL NDA 14 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2045 TABLET, EXTENDED RELEASE 120 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2046 TABLET, EXTENDED RELEASE 180 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2047 TABLET, EXTENDED RELEASE 240 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2048 TABLET, EXTENDED RELEASE 300 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2049 TABLET, EXTENDED RELEASE 360 mg ORAL NDA 25 sections
Cardizem LA HUMAN PRESCRIPTION DRUG LABEL 1 0187-2050 TABLET, EXTENDED RELEASE 420 mg ORAL NDA 25 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2612 CAPSULE, EXTENDED RELEASE 120 mg ORAL NDA 23 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2612 CAPSULE, EXTENDED RELEASE 120 mg ORAL NDA 23 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2613 CAPSULE, EXTENDED RELEASE 180 mg ORAL NDA 23 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2613 CAPSULE, EXTENDED RELEASE 180 mg ORAL NDA 23 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2614 CAPSULE, EXTENDED RELEASE 240 mg ORAL NDA 23 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2614 CAPSULE, EXTENDED RELEASE 240 mg ORAL NDA 23 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2615 CAPSULE, EXTENDED RELEASE 300 mg ORAL NDA 23 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2615 CAPSULE, EXTENDED RELEASE 300 mg ORAL NDA 23 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2616 CAPSULE, EXTENDED RELEASE 360 mg ORAL NDA 23 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2616 CAPSULE, EXTENDED RELEASE 360 mg ORAL NDA 23 sections
TIAZACEXTENDED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 0187-2617 CAPSULE, EXTENDED RELEASE 420 mg ORAL NDA 23 sections