Stem definition | Drug id | CAS RN |
---|---|---|
calcium channel blockers, diltiazem derivatives | 897 | 42399-41-7 |
Dose | Unit | Route |
---|---|---|
0.24 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 2 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 19.30 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 38 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 4.10 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 13 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.18 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 5.60 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 5, 1982 | FDA | VALEANT INTL |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Atrial fibrillation | 541.41 | 10.10 | 784 | 90271 | 100961 | 50413108 |
Completed suicide | 414.92 | 10.10 | 803 | 90252 | 131086 | 50382983 |
Sedation complication | 402.38 | 10.10 | 230 | 90825 | 8536 | 50505533 |
Creatinine renal clearance decreased | 391.37 | 10.10 | 252 | 90803 | 11629 | 50502440 |
Orthostatic hypotension | 350.74 | 10.10 | 343 | 90712 | 29138 | 50484931 |
Hypotension | 314.28 | 10.10 | 1034 | 90021 | 234435 | 50279634 |
Cardiac failure congestive | 273.97 | 10.10 | 521 | 90534 | 83861 | 50430208 |
Sedation | 257.16 | 10.10 | 296 | 90759 | 30314 | 50483755 |
Blood calcium decreased | 255.82 | 10.10 | 246 | 90809 | 20460 | 50493609 |
Maternal exposure during pregnancy | 220.02 | 10.10 | 18 | 91037 | 159760 | 50354309 |
Cognitive disorder | 218.46 | 10.10 | 329 | 90726 | 43794 | 50470275 |
Balance disorder | 214.60 | 10.10 | 424 | 90631 | 70166 | 50443903 |
Drug ineffective | 206.88 | 10.10 | 770 | 90285 | 818563 | 49695506 |
Toxicity to various agents | 186.74 | 10.10 | 817 | 90238 | 211682 | 50302387 |
Pemphigus | 185.45 | 10.10 | 7 | 91048 | 120159 | 50393910 |
Bradycardia | 183.90 | 10.10 | 377 | 90678 | 64049 | 50450020 |
Depressed level of consciousness | 183.84 | 10.10 | 333 | 90722 | 51620 | 50462449 |
Off label use | 164.10 | 10.10 | 384 | 90671 | 474042 | 50040027 |
Synovitis | 152.49 | 10.10 | 21 | 91034 | 123844 | 50390225 |
Fall | 145.81 | 10.10 | 1066 | 89989 | 333866 | 50180203 |
Hand deformity | 144.48 | 10.10 | 9 | 91046 | 100190 | 50413879 |
Nerve injury | 144.42 | 10.10 | 120 | 90935 | 8230 | 50505839 |
Treatment failure | 134.97 | 10.10 | 40 | 91015 | 137597 | 50376472 |
Exposure during pregnancy | 132.51 | 10.10 | 28 | 91027 | 120987 | 50393082 |
Systemic lupus erythematosus | 132.30 | 10.10 | 44 | 91011 | 140578 | 50373491 |
Dyspnoea | 131.60 | 10.10 | 1533 | 89522 | 546075 | 49967994 |
Glossodynia | 121.99 | 10.10 | 29 | 91026 | 115540 | 50398529 |
Drug intolerance | 114.93 | 10.10 | 135 | 90920 | 218969 | 50295100 |
Rheumatoid arthritis | 113.72 | 10.10 | 118 | 90937 | 202432 | 50311637 |
Therapeutic product effect decreased | 110.90 | 10.10 | 53 | 91002 | 135997 | 50378072 |
Dyspnoea exertional | 110.36 | 10.10 | 268 | 90787 | 50965 | 50463104 |
Alopecia | 106.46 | 10.10 | 173 | 90882 | 244874 | 50269195 |
Pulmonary congestion | 101.30 | 10.10 | 131 | 90924 | 15116 | 50498953 |
Arthropathy | 99.21 | 10.10 | 83 | 90972 | 157823 | 50356246 |
Neutropenia | 98.99 | 10.10 | 73 | 90982 | 147892 | 50366177 |
Hepatic enzyme increased | 96.89 | 10.10 | 64 | 90991 | 137316 | 50376753 |
Product use issue | 93.37 | 10.10 | 79 | 90976 | 149396 | 50364673 |
Heart rate increased | 91.94 | 10.10 | 327 | 90728 | 76923 | 50437146 |
Discomfort | 91.78 | 10.10 | 40 | 91015 | 108340 | 50405729 |
Joint swelling | 91.56 | 10.10 | 190 | 90865 | 245096 | 50268973 |
Fluid retention | 91.54 | 10.10 | 248 | 90807 | 50401 | 50463668 |
Pericarditis | 90.79 | 10.10 | 16 | 91039 | 78673 | 50435396 |
Contraindicated product administered | 87.92 | 10.10 | 83 | 90972 | 148875 | 50365194 |
Wound | 85.01 | 10.10 | 42 | 91013 | 105752 | 50408317 |
Infusion related reaction | 84.11 | 10.10 | 109 | 90946 | 169448 | 50344621 |
Nephrolithiasis | 81.78 | 10.10 | 188 | 90867 | 34505 | 50479564 |
Febrile neutropenia | 78.13 | 10.10 | 39 | 91016 | 97628 | 50416441 |
Constipation | 76.55 | 10.10 | 584 | 90471 | 185124 | 50328945 |
Pulmonary arterial hypertension | 75.37 | 10.10 | 133 | 90922 | 20186 | 50493883 |
Chest pain | 71.09 | 10.10 | 553 | 90502 | 176329 | 50337740 |
Atrioventricular block second degree | 71.00 | 10.10 | 56 | 90999 | 3565 | 50510504 |
Labile blood pressure | 69.39 | 10.10 | 41 | 91014 | 1619 | 50512450 |
Rash | 69.26 | 10.10 | 482 | 90573 | 436989 | 50077080 |
Gastrointestinal haemorrhage | 68.12 | 10.10 | 287 | 90768 | 73034 | 50441035 |
Bunion operation | 66.44 | 10.10 | 35 | 91020 | 1102 | 50512967 |
Respiratory tract congestion | 66.18 | 10.10 | 103 | 90952 | 14096 | 50499973 |
Suspected suicide | 64.93 | 10.10 | 63 | 90992 | 5294 | 50508775 |
Systemic lupus erythematosus rash | 64.73 | 10.10 | 40 | 91015 | 1715 | 50512354 |
Chronic obstructive pulmonary disease | 64.25 | 10.10 | 227 | 90828 | 53208 | 50460861 |
Pneumonia | 59.37 | 10.10 | 983 | 90072 | 377418 | 50136651 |
Atrioventricular block complete | 58.96 | 10.10 | 69 | 90986 | 7186 | 50506883 |
Mobility decreased | 58.70 | 10.10 | 292 | 90763 | 79656 | 50434413 |
Body tinea | 56.06 | 10.10 | 33 | 91022 | 1294 | 50512775 |
Inhibitory drug interaction | 53.66 | 10.10 | 39 | 91016 | 2194 | 50511875 |
Musculoskeletal stiffness | 52.69 | 10.10 | 94 | 90961 | 128387 | 50385682 |
Malignant neoplasm progression | 51.82 | 10.10 | 29 | 91026 | 68095 | 50445974 |
Therapeutic product effect incomplete | 51.65 | 10.10 | 53 | 91002 | 91462 | 50422607 |
Abortion spontaneous | 51.57 | 10.10 | 7 | 91048 | 41765 | 50472304 |
Cardiogenic shock | 51.38 | 10.10 | 97 | 90958 | 15502 | 50498567 |
Atrial flutter | 48.64 | 10.10 | 69 | 90986 | 8694 | 50505375 |
Oedema peripheral | 47.82 | 10.10 | 464 | 90591 | 157497 | 50356572 |
Leukopenia | 46.85 | 10.10 | 32 | 91023 | 67496 | 50446573 |
Abdominal discomfort | 46.18 | 10.10 | 237 | 90818 | 231404 | 50282665 |
General physical health deterioration | 46.10 | 10.10 | 119 | 90936 | 142315 | 50371754 |
Nodal rhythm | 45.79 | 10.10 | 31 | 91024 | 1556 | 50512513 |
Death | 45.13 | 10.10 | 829 | 90226 | 324550 | 50189519 |
Alveolitis | 45.03 | 10.10 | 37 | 91018 | 2497 | 50511572 |
Asthma | 44.35 | 10.10 | 294 | 90761 | 89043 | 50425026 |
Helicobacter infection | 44.24 | 10.10 | 17 | 91038 | 49685 | 50464384 |
Coronary artery disease | 43.51 | 10.10 | 135 | 90920 | 29591 | 50484478 |
Folliculitis | 43.06 | 10.10 | 9 | 91046 | 39216 | 50474853 |
Injection site erythema | 42.74 | 10.10 | 43 | 91012 | 74893 | 50439176 |
Pain in jaw | 41.76 | 10.10 | 158 | 90897 | 38270 | 50475799 |
Dizziness | 41.45 | 10.10 | 863 | 90192 | 345506 | 50168563 |
Hypoxia | 41.33 | 10.10 | 192 | 90863 | 50931 | 50463138 |
Palpitations | 41.02 | 10.10 | 301 | 90754 | 94205 | 50419864 |
Hunger | 40.54 | 10.10 | 44 | 91011 | 4219 | 50509850 |
Product use in unapproved indication | 40.43 | 10.10 | 93 | 90962 | 115726 | 50398343 |
Renal failure | 40.39 | 10.10 | 329 | 90726 | 106304 | 50407765 |
Stomatitis | 39.90 | 10.10 | 76 | 90979 | 101268 | 50412801 |
Cardiac disorder | 39.72 | 10.10 | 168 | 90887 | 42811 | 50471258 |
Hepatic ischaemia | 39.31 | 10.10 | 20 | 91035 | 585 | 50513484 |
Pregnancy | 38.88 | 10.10 | 4 | 91051 | 29573 | 50484496 |
Pericardial haemorrhage | 38.57 | 10.10 | 27 | 91028 | 1431 | 50512638 |
Pulmonary hypertension | 38.49 | 10.10 | 140 | 90915 | 33277 | 50480792 |
Atrioventricular block first degree | 37.67 | 10.10 | 51 | 91004 | 6150 | 50507919 |
Vasoplegia syndrome | 37.59 | 10.10 | 24 | 91031 | 1090 | 50512979 |
Thrombocytopenia | 36.63 | 10.10 | 113 | 90942 | 127560 | 50386509 |
Infection susceptibility increased | 36.33 | 10.10 | 33 | 91022 | 2551 | 50511518 |
Bezoar | 35.75 | 10.10 | 25 | 91030 | 1323 | 50512746 |
Arthralgia | 35.71 | 10.10 | 565 | 90490 | 438137 | 50075932 |
Angina pectoris | 35.65 | 10.10 | 116 | 90939 | 26072 | 50487997 |
Heart rate decreased | 35.56 | 10.10 | 145 | 90910 | 36352 | 50477717 |
Limb injury | 35.42 | 10.10 | 98 | 90957 | 20152 | 50493917 |
Pyrexia | 34.98 | 10.10 | 478 | 90577 | 379725 | 50134344 |
Myocardial infarction | 33.88 | 10.10 | 275 | 90780 | 88752 | 50425317 |
Cough | 33.51 | 10.10 | 615 | 90440 | 240649 | 50273420 |
Bronchitis | 33.50 | 10.10 | 310 | 90745 | 103849 | 50410220 |
Hospitalisation | 33.36 | 10.10 | 223 | 90832 | 67714 | 50446355 |
Blister | 32.80 | 10.10 | 65 | 90990 | 85353 | 50428716 |
Ill-defined disorder | 32.75 | 10.10 | 30 | 91025 | 54624 | 50459445 |
Foot deformity | 32.65 | 10.10 | 92 | 90963 | 19118 | 50494951 |
Muscle injury | 32.52 | 10.10 | 13 | 91042 | 37098 | 50476971 |
Urinary tract discomfort | 31.96 | 10.10 | 13 | 91042 | 222 | 50513847 |
Muscle relaxant therapy | 31.94 | 10.10 | 12 | 91043 | 164 | 50513905 |
Oedema | 31.88 | 10.10 | 226 | 90829 | 69955 | 50444114 |
Cardiac arrest | 31.61 | 10.10 | 258 | 90797 | 83393 | 50430676 |
White blood cell count decreased | 31.60 | 10.10 | 106 | 90949 | 116616 | 50397453 |
Transfusion | 31.59 | 10.10 | 71 | 90984 | 12834 | 50501235 |
Intentional product use issue | 30.87 | 10.10 | 57 | 90998 | 76861 | 50437208 |
Asthenia | 30.68 | 10.10 | 771 | 90284 | 318271 | 50195798 |
Impaired quality of life | 29.72 | 10.10 | 45 | 91010 | 6011 | 50508058 |
BRASH syndrome | 29.71 | 10.10 | 12 | 91043 | 201 | 50513868 |
Forced expiratory volume decreased | 29.57 | 10.10 | 38 | 91017 | 4356 | 50509713 |
Hypervolaemia | 29.51 | 10.10 | 107 | 90948 | 25392 | 50488677 |
Blood pressure systolic increased | 29.28 | 10.10 | 134 | 90921 | 35315 | 50478754 |
Pancytopenia | 28.90 | 10.10 | 68 | 90987 | 83962 | 50430107 |
Atrioventricular block | 28.81 | 10.10 | 46 | 91009 | 6432 | 50507637 |
Full blood count abnormal | 28.66 | 10.10 | 100 | 90955 | 23288 | 50490781 |
Pulseless electrical activity | 28.29 | 10.10 | 47 | 91008 | 6794 | 50507275 |
Intentional self-injury | 28.23 | 10.10 | 4 | 91051 | 23108 | 50490961 |
Productive cough | 27.72 | 10.10 | 176 | 90879 | 52518 | 50461551 |
Erythromelalgia | 27.71 | 10.10 | 10 | 91045 | 121 | 50513948 |
Gastrointestinal disorder | 27.51 | 10.10 | 83 | 90972 | 94373 | 50419696 |
Heart sounds | 27.49 | 10.10 | 16 | 91039 | 614 | 50513455 |
Rales | 26.81 | 10.10 | 57 | 90998 | 9921 | 50504148 |
Alveolar osteitis | 26.80 | 10.10 | 14 | 91041 | 433 | 50513636 |
Neutrophil count decreased | 26.71 | 10.10 | 26 | 91029 | 46000 | 50468069 |
Poor quality sleep | 26.62 | 10.10 | 78 | 90977 | 16568 | 50497501 |
Mucosal inflammation | 26.56 | 10.10 | 20 | 91035 | 40122 | 50473947 |
Arteriovenous fistula occlusion | 26.00 | 10.10 | 13 | 91042 | 366 | 50513703 |
Sleep disorder due to general medical condition, insomnia type | 25.99 | 10.10 | 12 | 91043 | 31435 | 50482634 |
Hepatorenal syndrome | 25.97 | 10.10 | 23 | 91032 | 1720 | 50512349 |
Cardiac failure | 25.81 | 10.10 | 229 | 90826 | 75811 | 50438258 |
Weight decreased | 25.68 | 10.10 | 549 | 90506 | 220696 | 50293373 |
Unevaluable event | 25.57 | 10.10 | 156 | 90899 | 45910 | 50468159 |
Hyperkalaemia | 25.53 | 10.10 | 161 | 90894 | 47928 | 50466141 |
Gouty tophus | 25.53 | 10.10 | 10 | 91045 | 154 | 50513915 |
Prolonged expiration | 25.50 | 10.10 | 16 | 91039 | 705 | 50513364 |
Cardiac pacemaker insertion | 25.23 | 10.10 | 32 | 91023 | 3621 | 50510448 |
Blue toe syndrome | 25.16 | 10.10 | 13 | 91042 | 393 | 50513676 |
Bladder prolapse | 25.10 | 10.10 | 23 | 91032 | 1798 | 50512271 |
Glucose tolerance impaired | 25.08 | 10.10 | 38 | 91017 | 5080 | 50508989 |
Condition aggravated | 24.99 | 10.10 | 380 | 90675 | 296678 | 50217391 |
Foetal exposure during pregnancy | 24.94 | 10.10 | 9 | 91046 | 27350 | 50486719 |
Cerebrovascular accident | 24.75 | 10.10 | 270 | 90785 | 94410 | 50419659 |
Kidney infection | 24.59 | 10.10 | 82 | 90973 | 18664 | 50495405 |
Device pacing issue | 24.39 | 10.10 | 8 | 91047 | 71 | 50513998 |
C-reactive protein increased | 24.32 | 10.10 | 52 | 91003 | 66422 | 50447647 |
Erythrodermic psoriasis | 24.24 | 10.10 | 17 | 91038 | 904 | 50513165 |
Suicidal ideation | 24.09 | 10.10 | 39 | 91016 | 55346 | 50458723 |
Nasal congestion | 24.02 | 10.10 | 166 | 90889 | 50954 | 50463115 |
Coagulopathy | 23.99 | 10.10 | 79 | 90976 | 17865 | 50496204 |
Nephroangiosclerosis | 23.56 | 10.10 | 9 | 91046 | 129 | 50513940 |
Irritable bowel syndrome | 23.54 | 10.10 | 35 | 91020 | 51406 | 50462663 |
Myopathy | 23.18 | 10.10 | 51 | 91004 | 9088 | 50504981 |
Blood iron decreased | 23.14 | 10.10 | 59 | 90996 | 11556 | 50502513 |
Oxygen saturation decreased | 22.54 | 10.10 | 216 | 90839 | 73032 | 50441037 |
Heart rate irregular | 22.20 | 10.10 | 81 | 90974 | 19279 | 50494790 |
Stent placement | 21.99 | 10.10 | 29 | 91026 | 3409 | 50510660 |
Pulmonary oedema | 21.87 | 10.10 | 157 | 90898 | 48781 | 50465288 |
Red blood cell sedimentation rate increased | 21.69 | 10.10 | 13 | 91042 | 29403 | 50484666 |
Drug resistance | 21.59 | 10.10 | 4 | 91051 | 18985 | 50495084 |
Torsade de pointes | 21.42 | 10.10 | 58 | 90997 | 11777 | 50502292 |
Premature delivery | 21.21 | 10.10 | 8 | 91047 | 23655 | 50490414 |
Cardiac ablation | 21.14 | 10.10 | 18 | 91037 | 1276 | 50512793 |
Tunnel vision | 20.64 | 10.10 | 14 | 91041 | 705 | 50513364 |
Supraventricular tachycardia | 20.49 | 10.10 | 60 | 90995 | 12741 | 50501328 |
Paranasal sinus discomfort | 20.37 | 10.10 | 26 | 91029 | 2960 | 50511109 |
Rectal prolapse | 20.13 | 10.10 | 20 | 91035 | 1729 | 50512340 |
Hepatotoxicity | 20.12 | 10.10 | 12 | 91043 | 27214 | 50486855 |
Blood pressure increased | 20.10 | 10.10 | 344 | 90711 | 132788 | 50381281 |
Seizure | 20.00 | 10.10 | 127 | 90928 | 117747 | 50396322 |
Peak expiratory flow rate abnormal | 20.00 | 10.10 | 7 | 91048 | 77 | 50513992 |
Disease progression | 19.69 | 10.10 | 97 | 90958 | 95769 | 50418300 |
Injection site pain | 19.68 | 10.10 | 118 | 90937 | 110906 | 50403163 |
Liver injury | 19.68 | 10.10 | 10 | 91045 | 24796 | 50489273 |
Live birth | 19.67 | 10.10 | 3 | 91052 | 16405 | 50497664 |
Swelling | 19.35 | 10.10 | 250 | 90805 | 200622 | 50313447 |
Feeling cold | 19.34 | 10.10 | 78 | 90977 | 19453 | 50494616 |
Syncope | 19.29 | 10.10 | 276 | 90779 | 102726 | 50411343 |
Bone marrow failure | 19.28 | 10.10 | 13 | 91042 | 27611 | 50486458 |
Medication error | 19.24 | 10.10 | 121 | 90934 | 35983 | 50478086 |
Bladder pain | 19.10 | 10.10 | 19 | 91036 | 1645 | 50512424 |
International normalised ratio increased | 19.03 | 10.10 | 138 | 90917 | 43014 | 50471055 |
Injection site pruritus | 18.98 | 10.10 | 27 | 91028 | 40384 | 50473685 |
Presyncope | 18.90 | 10.10 | 90 | 90965 | 24108 | 50489961 |
Cardioversion | 18.86 | 10.10 | 16 | 91039 | 1129 | 50512940 |
Knee arthroplasty | 18.85 | 10.10 | 22 | 91033 | 35824 | 50478245 |
Confusional state | 18.80 | 10.10 | 229 | 90826 | 185699 | 50328370 |
Product complaint | 18.60 | 10.10 | 54 | 91001 | 11412 | 50502657 |
Premature baby | 18.56 | 10.10 | 5 | 91050 | 18332 | 50495737 |
Colon gangrene | 18.52 | 10.10 | 4 | 91051 | 4 | 50514065 |
Alanine aminotransferase increased | 18.38 | 10.10 | 89 | 90966 | 88270 | 50425799 |
Thermal burn | 18.35 | 10.10 | 32 | 91023 | 4809 | 50509260 |
Ventricular arrhythmia | 18.28 | 10.10 | 26 | 91029 | 3283 | 50510786 |
Blood pressure diastolic decreased | 18.23 | 10.10 | 69 | 90986 | 16712 | 50497357 |
Occult blood | 18.13 | 10.10 | 16 | 91039 | 1191 | 50512878 |
Stupor | 18.12 | 10.10 | 27 | 91028 | 3556 | 50510513 |
Cellulitis | 18.09 | 10.10 | 201 | 90854 | 70597 | 50443472 |
Urticaria | 17.92 | 10.10 | 148 | 90907 | 129413 | 50384656 |
Tooth infection | 17.86 | 10.10 | 61 | 90994 | 14051 | 50500018 |
Oxygen therapy | 17.75 | 10.10 | 19 | 91036 | 1793 | 50512276 |
Gastrooesophageal reflux disease | 17.74 | 10.10 | 213 | 90842 | 76215 | 50437854 |
Disturbance in attention | 17.66 | 10.10 | 18 | 91037 | 31168 | 50482901 |
Sinus bradycardia | 17.59 | 10.10 | 58 | 90997 | 13125 | 50500944 |
Wound complication | 17.29 | 10.10 | 23 | 91032 | 2727 | 50511342 |
Aortic arteriosclerosis | 17.15 | 10.10 | 33 | 91022 | 5349 | 50508720 |
Carbon dioxide increased | 17.02 | 10.10 | 15 | 91040 | 1114 | 50512955 |
Lower gastrointestinal haemorrhage | 17.01 | 10.10 | 38 | 91017 | 6841 | 50507228 |
Myocardial hypoxia | 16.91 | 10.10 | 4 | 91051 | 8 | 50514061 |
Humidity intolerance | 16.84 | 10.10 | 9 | 91046 | 292 | 50513777 |
Cerebellar syndrome | 16.82 | 10.10 | 25 | 91030 | 3286 | 50510783 |
Product residue present | 16.23 | 10.10 | 26 | 91029 | 3646 | 50510423 |
Night sweats | 16.20 | 10.10 | 22 | 91033 | 33552 | 50480517 |
Acute lung injury | 16.17 | 10.10 | 16 | 91039 | 1377 | 50512692 |
Renal pain | 16.15 | 10.10 | 33 | 91022 | 5586 | 50508483 |
Skin laceration | 16.14 | 10.10 | 72 | 90983 | 18770 | 50495299 |
Electrocardiogram QRS complex prolonged | 16.09 | 10.10 | 32 | 91023 | 5312 | 50508757 |
Catheter site erythema | 16.09 | 10.10 | 27 | 91028 | 3935 | 50510134 |
Respiratory rate increased | 16.01 | 10.10 | 51 | 91004 | 11334 | 50502735 |
Aspartate aminotransferase increased | 15.97 | 10.10 | 79 | 90976 | 77919 | 50436150 |
Unresponsive to stimuli | 15.95 | 10.10 | 102 | 90953 | 30507 | 50483562 |
Obstructive airways disorder | 15.89 | 10.10 | 63 | 90992 | 15589 | 50498480 |
Hyperlipidaemia | 15.87 | 10.10 | 68 | 90987 | 17422 | 50496647 |
Drug abuse | 15.75 | 10.10 | 55 | 91000 | 59791 | 50454278 |
Coronary artery bypass | 15.70 | 10.10 | 20 | 91035 | 2273 | 50511796 |
Electrocardiogram U wave present | 15.65 | 10.10 | 6 | 91049 | 87 | 50513982 |
Animal scratch | 15.61 | 10.10 | 13 | 91042 | 894 | 50513175 |
Anion gap abnormal | 15.59 | 10.10 | 9 | 91046 | 340 | 50513729 |
Ventricular tachycardia | 15.52 | 10.10 | 63 | 90992 | 15758 | 50498311 |
Malaise | 15.27 | 10.10 | 744 | 90311 | 334788 | 50179281 |
Posterior reversible encephalopathy syndrome | 15.25 | 10.10 | 4 | 91051 | 14924 | 50499145 |
Sinoatrial block | 15.22 | 10.10 | 12 | 91043 | 763 | 50513306 |
Nodal arrhythmia | 15.11 | 10.10 | 14 | 91041 | 1110 | 50512959 |
Drug interaction | 15.10 | 10.10 | 468 | 90587 | 199153 | 50314916 |
Incision site haemorrhage | 15.08 | 10.10 | 10 | 91045 | 485 | 50513584 |
Pain in extremity | 15.03 | 10.10 | 617 | 90438 | 272248 | 50241821 |
Drug-induced liver injury | 15.03 | 10.10 | 17 | 91038 | 28078 | 50485991 |
Injection site swelling | 15.01 | 10.10 | 33 | 91022 | 41740 | 50472329 |
Polymyalgia rheumatica | 14.99 | 10.10 | 21 | 91034 | 2615 | 50511454 |
Status epilepticus | 14.87 | 10.10 | 3 | 91052 | 13403 | 50500666 |
Seasonal allergy | 14.84 | 10.10 | 59 | 90996 | 14617 | 50499452 |
Sleep disorder | 14.83 | 10.10 | 53 | 91002 | 57230 | 50456839 |
Leukaemoid reaction | 14.73 | 10.10 | 7 | 91048 | 176 | 50513893 |
Respiration abnormal | 14.71 | 10.10 | 30 | 91025 | 5072 | 50508997 |
Gravitational oedema | 14.68 | 10.10 | 14 | 91041 | 1151 | 50512918 |
Anaphylactic reaction | 14.68 | 10.10 | 49 | 91006 | 54006 | 50460063 |
Hip arthroplasty | 14.62 | 10.10 | 20 | 91035 | 30409 | 50483660 |
Drug hypersensitivity | 14.61 | 10.10 | 342 | 90713 | 250668 | 50263401 |
Cardiac monitoring | 14.50 | 10.10 | 4 | 91051 | 18 | 50514051 |
Purpura | 14.49 | 10.10 | 45 | 91010 | 9866 | 50504203 |
Cardiac valve disease | 14.32 | 10.10 | 25 | 91030 | 3761 | 50510308 |
Sebaceous gland infection | 14.31 | 10.10 | 6 | 91049 | 111 | 50513958 |
Pollakiuria | 14.02 | 10.10 | 82 | 90973 | 23769 | 50490300 |
Infusion site warmth | 13.98 | 10.10 | 15 | 91040 | 1419 | 50512650 |
Catheter site haemorrhage | 13.96 | 10.10 | 21 | 91034 | 2789 | 50511280 |
Catheter site discharge | 13.92 | 10.10 | 17 | 91038 | 1851 | 50512218 |
Blood loss anaemia | 13.85 | 10.10 | 39 | 91016 | 8100 | 50505969 |
Arrhythmogenic right ventricular dysplasia | 13.84 | 10.10 | 4 | 91051 | 22 | 50514047 |
Chronic respiratory failure | 13.83 | 10.10 | 16 | 91039 | 1646 | 50512423 |
Electrocardiogram QT shortened | 13.75 | 10.10 | 6 | 91049 | 123 | 50513946 |
Orthopnoea | 13.59 | 10.10 | 31 | 91024 | 5658 | 50508411 |
Chondrocalcinosis | 13.51 | 10.10 | 10 | 91045 | 579 | 50513490 |
Respiratory acidosis | 13.47 | 10.10 | 32 | 91023 | 5996 | 50508073 |
Oral herpes | 13.33 | 10.10 | 73 | 90982 | 20652 | 50493417 |
Atrioventricular dissociation | 13.33 | 10.10 | 7 | 91048 | 219 | 50513850 |
Fibrous histiocytoma | 13.32 | 10.10 | 9 | 91046 | 450 | 50513619 |
Metastases to liver | 13.32 | 10.10 | 10 | 91045 | 20094 | 50493975 |
Injection site inflammation | 13.23 | 10.10 | 22 | 91033 | 3183 | 50510886 |
Cytomegalovirus infection | 13.15 | 10.10 | 8 | 91047 | 17954 | 50496115 |
Cardioactive drug level increased | 13.10 | 10.10 | 17 | 91038 | 1967 | 50512102 |
Histoplasmosis | 13.09 | 10.10 | 16 | 91039 | 1743 | 50512326 |
Anal abscess | 13.02 | 10.10 | 24 | 91031 | 3767 | 50510302 |
Blood pressure inadequately controlled | 12.92 | 10.10 | 26 | 91029 | 4354 | 50509715 |
Liver disorder | 12.89 | 10.10 | 30 | 91025 | 37192 | 50476877 |
Depression | 12.75 | 10.10 | 215 | 90840 | 165208 | 50348861 |
Chest discomfort | 12.71 | 10.10 | 236 | 90819 | 92486 | 50421583 |
Pruritus | 12.70 | 10.10 | 401 | 90654 | 283167 | 50230902 |
Bladder disorder | 12.69 | 10.10 | 36 | 91019 | 7507 | 50506562 |
Inflammation | 12.62 | 10.10 | 56 | 90999 | 56856 | 50457213 |
Bronchopulmonary aspergillosis allergic | 12.58 | 10.10 | 13 | 91042 | 1178 | 50512891 |
Aortic stenosis | 12.49 | 10.10 | 25 | 91030 | 4169 | 50509900 |
Product commingling | 12.47 | 10.10 | 6 | 91049 | 155 | 50513914 |
Arrhythmia | 12.41 | 10.10 | 102 | 90953 | 33030 | 50481039 |
Sinusitis | 12.40 | 10.10 | 224 | 90831 | 170334 | 50343735 |
Pulmonary embolism | 12.38 | 10.10 | 120 | 90935 | 101584 | 50412485 |
Mastication disorder | 12.38 | 10.10 | 16 | 91039 | 1844 | 50512225 |
Distributive shock | 12.35 | 10.10 | 11 | 91044 | 829 | 50513240 |
Multiple sclerosis relapse | 12.33 | 10.10 | 38 | 91017 | 42926 | 50471143 |
Neutropenic sepsis | 12.32 | 10.10 | 5 | 91050 | 14142 | 50499927 |
Sinus node dysfunction | 12.29 | 10.10 | 24 | 91031 | 3931 | 50510138 |
Infusion site erythema | 12.19 | 10.10 | 39 | 91016 | 8688 | 50505381 |
Aggression | 12.17 | 10.10 | 12 | 91043 | 21104 | 50492965 |
Catheter site inflammation | 12.14 | 10.10 | 10 | 91045 | 677 | 50513392 |
Muscle spasticity | 12.11 | 10.10 | 8 | 91047 | 17176 | 50496893 |
Haemarthrosis | 12.05 | 10.10 | 20 | 91035 | 2888 | 50511181 |
Infusion site pain | 11.98 | 10.10 | 49 | 91006 | 12297 | 50501772 |
Premature labour | 11.86 | 10.10 | 3 | 91052 | 11473 | 50502596 |
Metastases to bone | 11.86 | 10.10 | 9 | 91046 | 17986 | 50496083 |
Coronary artery occlusion | 11.85 | 10.10 | 35 | 91020 | 7468 | 50506601 |
Sopor | 11.80 | 10.10 | 11 | 91044 | 19868 | 50494201 |
Bronchiectasis | 11.77 | 10.10 | 43 | 91012 | 10240 | 50503829 |
Bundle branch block left | 11.75 | 10.10 | 31 | 91024 | 6199 | 50507870 |
Total lung capacity decreased | 11.71 | 10.10 | 13 | 91042 | 1278 | 50512791 |
Joint stiffness | 11.68 | 10.10 | 23 | 91032 | 30285 | 50483784 |
Oxygen consumption increased | 11.66 | 10.10 | 22 | 91033 | 3514 | 50510555 |
Acute generalised exanthematous pustulosis | 11.63 | 10.10 | 39 | 91016 | 8899 | 50505170 |
Metastases to central nervous system | 11.57 | 10.10 | 3 | 91052 | 11279 | 50502790 |
Abnormal behaviour | 11.53 | 10.10 | 11 | 91044 | 19647 | 50494422 |
Wrong technique in product usage process | 11.49 | 10.10 | 56 | 90999 | 55454 | 50458615 |
Ear congestion | 11.45 | 10.10 | 16 | 91039 | 1987 | 50512082 |
Agranulocytosis | 11.42 | 10.10 | 13 | 91042 | 21408 | 50492661 |
Caesarean section | 11.40 | 10.10 | 7 | 91048 | 15632 | 50498437 |
Duodenal polyp | 11.35 | 10.10 | 5 | 91050 | 105 | 50513964 |
Infusion site infection | 11.34 | 10.10 | 14 | 91041 | 1541 | 50512528 |
Intervertebral disc space narrowing | 11.32 | 10.10 | 11 | 91044 | 926 | 50513143 |
Haematemesis | 11.28 | 10.10 | 87 | 90968 | 27638 | 50486431 |
Angina unstable | 11.28 | 10.10 | 32 | 91023 | 6674 | 50507395 |
Lower respiratory tract congestion | 11.25 | 10.10 | 16 | 91039 | 2020 | 50512049 |
Accidental exposure to product | 11.23 | 10.10 | 15 | 91040 | 23042 | 50491027 |
Vitamin D decreased | 11.23 | 10.10 | 37 | 91018 | 8369 | 50505700 |
Psoriatic arthropathy | 11.21 | 10.10 | 45 | 91010 | 46987 | 50467082 |
Aspiration pleural cavity | 11.21 | 10.10 | 10 | 91045 | 755 | 50513314 |
Hypovolaemia | 11.19 | 10.10 | 40 | 91015 | 9425 | 50504644 |
Nasal polyps | 11.17 | 10.10 | 18 | 91037 | 2536 | 50511533 |
Injection site urticaria | 11.17 | 10.10 | 4 | 91051 | 12213 | 50501856 |
Spondyloarthropathy | 11.13 | 10.10 | 10 | 91045 | 762 | 50513307 |
Blood pressure systolic | 11.04 | 10.10 | 4 | 91051 | 49 | 50514020 |
Gamma-glutamyltransferase increased | 10.98 | 10.10 | 23 | 91032 | 29600 | 50484469 |
Atrial appendage closure | 10.97 | 10.10 | 3 | 91052 | 13 | 50514056 |
Heart rate abnormal | 10.95 | 10.10 | 23 | 91032 | 3969 | 50510100 |
Inappropriate schedule of product administration | 10.89 | 10.10 | 80 | 90975 | 71751 | 50442318 |
Brain hypoxia | 10.88 | 10.10 | 8 | 91047 | 458 | 50513611 |
Infusion site discharge | 10.83 | 10.10 | 9 | 91046 | 617 | 50513452 |
Fatigue | 10.81 | 10.10 | 1112 | 89943 | 706489 | 49807580 |
Catheterisation cardiac | 10.76 | 10.10 | 23 | 91032 | 4017 | 50510052 |
Acute myeloid leukaemia | 10.64 | 10.10 | 7 | 91048 | 15067 | 50499002 |
Cataract | 10.62 | 10.10 | 131 | 90924 | 47169 | 50466900 |
Nodule | 10.58 | 10.10 | 9 | 91046 | 16994 | 50497075 |
Rectal haemorrhage | 10.55 | 10.10 | 111 | 90944 | 38447 | 50475622 |
Epilepsy | 10.54 | 10.10 | 14 | 91041 | 21553 | 50492516 |
Atrial pressure increased | 10.46 | 10.10 | 3 | 91052 | 16 | 50514053 |
Renal necrosis | 10.43 | 10.10 | 4 | 91051 | 58 | 50514011 |
Bone disorder | 10.42 | 10.10 | 11 | 91044 | 18741 | 50495328 |
Hypochromic anaemia | 10.38 | 10.10 | 14 | 91041 | 1682 | 50512387 |
Abdominal rigidity | 10.33 | 10.10 | 14 | 91041 | 1690 | 50512379 |
Catheter management | 10.25 | 10.10 | 18 | 91037 | 2721 | 50511348 |
Reperfusion arrhythmia | 10.24 | 10.10 | 6 | 91049 | 233 | 50513836 |
Circadian rhythm sleep disorder | 10.22 | 10.10 | 6 | 91049 | 234 | 50513835 |
Wound necrosis | 10.20 | 10.10 | 7 | 91048 | 359 | 50513710 |
Ectopic ACTH syndrome | 10.19 | 10.10 | 5 | 91050 | 135 | 50513934 |
Enterococcal sepsis | 10.15 | 10.10 | 12 | 91043 | 1263 | 50512806 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Atrial fibrillation | 234.85 | 10.77 | 527 | 47833 | 105119 | 29421048 |
Completed suicide | 213.86 | 10.77 | 462 | 47898 | 89784 | 29436383 |
Bradycardia | 195.99 | 10.77 | 370 | 47990 | 65259 | 29460908 |
Cardiac failure congestive | 143.84 | 10.77 | 358 | 48002 | 76223 | 29449944 |
Off label use | 99.74 | 10.77 | 215 | 48145 | 300585 | 29225582 |
Hypotension | 91.74 | 10.77 | 587 | 47773 | 193767 | 29332400 |
Dyspnoea | 84.77 | 10.77 | 860 | 47500 | 325872 | 29200295 |
Febrile neutropenia | 60.05 | 10.77 | 57 | 48303 | 112183 | 29413984 |
Myocardial infarction | 59.41 | 10.77 | 345 | 48015 | 109951 | 29416216 |
Chronic obstructive pulmonary disease | 52.67 | 10.77 | 167 | 48193 | 40788 | 29485379 |
BRASH syndrome | 50.38 | 10.77 | 16 | 48344 | 141 | 29526026 |
Cardiac arrest | 50.21 | 10.77 | 274 | 48086 | 85317 | 29440850 |
Suspected suicide | 48.15 | 10.77 | 45 | 48315 | 3975 | 29522192 |
Incision site pain | 47.59 | 10.77 | 32 | 48328 | 1751 | 29524416 |
Drug ineffective | 45.13 | 10.77 | 379 | 47981 | 362791 | 29163376 |
Neutropenia | 42.77 | 10.77 | 95 | 48265 | 131616 | 29394551 |
Conjunctivitis allergic | 42.72 | 10.77 | 21 | 48339 | 629 | 29525538 |
Mycotic allergy | 42.24 | 10.77 | 16 | 48344 | 248 | 29525919 |
Atrial flutter | 40.96 | 10.77 | 78 | 48282 | 13816 | 29512351 |
Mite allergy | 39.40 | 10.77 | 16 | 48344 | 301 | 29525866 |
Atrioventricular block complete | 38.47 | 10.77 | 56 | 48304 | 7955 | 29518212 |
Cardiogenic shock | 37.31 | 10.77 | 91 | 48269 | 19099 | 29507068 |
Atrioventricular block | 36.77 | 10.77 | 51 | 48309 | 6931 | 29519236 |
Spirometry abnormal | 36.72 | 10.77 | 16 | 48344 | 361 | 29525806 |
Pyrexia | 36.65 | 10.77 | 298 | 48062 | 287324 | 29238843 |
Foetal exposure during pregnancy | 36.07 | 10.77 | 6 | 48354 | 33861 | 29492306 |
Fluid retention | 35.88 | 10.77 | 102 | 48258 | 23458 | 29502709 |
Dizziness | 35.77 | 10.77 | 470 | 47890 | 189214 | 29336953 |
Pulmonary arterial hypertension | 35.67 | 10.77 | 52 | 48308 | 7397 | 29518770 |
General physical health deterioration | 35.20 | 10.77 | 72 | 48288 | 102785 | 29423382 |
Coronary artery disease | 33.36 | 10.77 | 152 | 48208 | 44038 | 29482129 |
Dust allergy | 32.74 | 10.77 | 16 | 48344 | 473 | 29525694 |
Cardioplegia | 32.51 | 10.77 | 6 | 48354 | 0 | 29526167 |
Drug interaction | 31.54 | 10.77 | 475 | 47885 | 196910 | 29329257 |
Red blood cells urine positive | 28.71 | 10.77 | 23 | 48337 | 1650 | 29524517 |
Atrioventricular block first degree | 28.23 | 10.77 | 39 | 48321 | 5280 | 29520887 |
Tetany | 28.18 | 10.77 | 16 | 48344 | 646 | 29525521 |
Arterial spasm | 27.24 | 10.77 | 9 | 48351 | 91 | 29526076 |
Product use in unapproved indication | 27.09 | 10.77 | 64 | 48296 | 86811 | 29439356 |
Antiacetylcholine receptor antibody positive | 27.05 | 10.77 | 8 | 48352 | 54 | 29526113 |
Oedema peripheral | 26.83 | 10.77 | 273 | 48087 | 103284 | 29422883 |
Pacemaker generated rhythm | 26.09 | 10.77 | 8 | 48352 | 62 | 29526105 |
Syncope | 24.27 | 10.77 | 221 | 48139 | 81150 | 29445017 |
Chest pain | 23.87 | 10.77 | 284 | 48076 | 111689 | 29414478 |
Cerebrovascular accident | 22.99 | 10.77 | 209 | 48151 | 76702 | 29449465 |
Gastrointestinal haemorrhage | 22.71 | 10.77 | 214 | 48146 | 79319 | 29446848 |
Productive cough | 22.46 | 10.77 | 106 | 48254 | 31153 | 29495014 |
Pancytopenia | 22.33 | 10.77 | 66 | 48294 | 83102 | 29443065 |
Prinzmetal angina | 21.93 | 10.77 | 15 | 48345 | 844 | 29525323 |
Thrombocytopenia | 21.88 | 10.77 | 130 | 48230 | 134693 | 29391474 |
Angina unstable | 21.62 | 10.77 | 52 | 48308 | 10813 | 29515354 |
Atrial thrombosis | 21.39 | 10.77 | 21 | 48339 | 1972 | 29524195 |
Neutrophil count decreased | 21.15 | 10.77 | 24 | 48336 | 43543 | 29482624 |
Chondrocalcinosis | 20.77 | 10.77 | 10 | 48350 | 286 | 29525881 |
Influenza virus test positive | 20.74 | 10.77 | 7 | 48353 | 76 | 29526091 |
Hypoxia | 20.35 | 10.77 | 140 | 48220 | 47239 | 29478928 |
Protein urine present | 19.96 | 10.77 | 31 | 48329 | 4663 | 29521504 |
Acquired haemophilia | 19.83 | 10.77 | 14 | 48346 | 829 | 29525338 |
Cardiac disorder | 19.65 | 10.77 | 116 | 48244 | 37147 | 29489020 |
Procedural pain | 19.42 | 10.77 | 29 | 48331 | 4215 | 29521952 |
Toxic optic neuropathy | 19.06 | 10.77 | 13 | 48347 | 728 | 29525439 |
Lymphocyte count decreased | 19.02 | 10.77 | 72 | 48288 | 19199 | 29506968 |
Angina pectoris | 18.97 | 10.77 | 93 | 48267 | 27757 | 29498410 |
Gallbladder polyp | 18.91 | 10.77 | 10 | 48350 | 350 | 29525817 |
Discharge | 18.59 | 10.77 | 8 | 48352 | 175 | 29525992 |
Urinary tract discomfort | 18.45 | 10.77 | 7 | 48353 | 109 | 29526058 |
Medication error | 18.32 | 10.77 | 76 | 48284 | 21135 | 29505032 |
Rectal fissure | 17.91 | 10.77 | 9 | 48351 | 283 | 29525884 |
Eczema infected | 17.85 | 10.77 | 5 | 48355 | 27 | 29526140 |
International normalised ratio increased | 17.82 | 10.77 | 129 | 48231 | 44243 | 29481924 |
Palpitations | 17.51 | 10.77 | 102 | 48258 | 32502 | 29493665 |
Hepatic function abnormal | 16.60 | 10.77 | 24 | 48336 | 39235 | 29486932 |
Heart rate irregular | 16.40 | 10.77 | 53 | 48307 | 13064 | 29513103 |
Nodal arrhythmia | 16.23 | 10.77 | 12 | 48348 | 764 | 29525403 |
Oxygen saturation decreased | 16 | 10.77 | 127 | 48233 | 44810 | 29481357 |
Distributive shock | 15.76 | 10.77 | 13 | 48347 | 972 | 29525195 |
Pneumocystis jirovecii pneumonia | 15.74 | 10.77 | 4 | 48356 | 16775 | 29509392 |
Tooth injury | 15.51 | 10.77 | 12 | 48348 | 818 | 29525349 |
Device dislocation | 15.35 | 10.77 | 27 | 48333 | 4500 | 29521667 |
Product use issue | 15.16 | 10.77 | 39 | 48321 | 51405 | 29474762 |
Malignant neoplasm progression | 14.92 | 10.77 | 66 | 48294 | 73793 | 29452374 |
White blood cell count decreased | 14.81 | 10.77 | 78 | 48282 | 83284 | 29442883 |
Angina bullosa haemorrhagica | 14.67 | 10.77 | 5 | 48355 | 56 | 29526111 |
Premature baby | 14.60 | 10.77 | 5 | 48355 | 17275 | 29508892 |
Septic shock | 14.47 | 10.77 | 53 | 48307 | 62507 | 29463660 |
Eosinophilic pleural effusion | 14.42 | 10.77 | 7 | 48353 | 204 | 29525963 |
Arteriosclerosis coronary artery | 14.32 | 10.77 | 44 | 48316 | 10561 | 29515606 |
Mast cell degranulation present | 14.14 | 10.77 | 5 | 48355 | 63 | 29526104 |
Vitiligo | 14.03 | 10.77 | 11 | 48349 | 765 | 29525402 |
Perineal pain | 13.95 | 10.77 | 11 | 48349 | 771 | 29525396 |
Hypervolaemia | 13.72 | 10.77 | 61 | 48299 | 17484 | 29508683 |
Mucosal inflammation | 13.67 | 10.77 | 19 | 48341 | 31576 | 29494591 |
Wheezing | 13.56 | 10.77 | 97 | 48263 | 33143 | 29493024 |
Heart rate decreased | 13.42 | 10.77 | 78 | 48282 | 24834 | 29501333 |
Pericardial haemorrhage | 13.37 | 10.77 | 20 | 48340 | 2911 | 29523256 |
Labyrinthitis | 13.35 | 10.77 | 11 | 48349 | 821 | 29525346 |
Ventricular fibrillation | 13.10 | 10.77 | 56 | 48304 | 15777 | 29510390 |
Neuroleptic malignant syndrome | 13.09 | 10.77 | 5 | 48355 | 16143 | 29510024 |
Subacute cutaneous lupus erythematosus | 13.05 | 10.77 | 11 | 48349 | 848 | 29525319 |
Lower gastrointestinal haemorrhage | 12.93 | 10.77 | 36 | 48324 | 8177 | 29517990 |
Aortic stenosis | 12.91 | 10.77 | 23 | 48337 | 3871 | 29522296 |
Aggression | 12.90 | 10.77 | 24 | 48336 | 35517 | 29490650 |
Peripheral swelling | 12.84 | 10.77 | 160 | 48200 | 63579 | 29462588 |
Brugada syndrome | 12.81 | 10.77 | 10 | 48350 | 691 | 29525476 |
Blood urine present | 12.73 | 10.77 | 40 | 48320 | 9715 | 29516452 |
Alveolar osteitis | 12.67 | 10.77 | 5 | 48355 | 87 | 29526080 |
Sepsis | 12.64 | 10.77 | 161 | 48199 | 142521 | 29383646 |
Drug resistance | 12.64 | 10.77 | 10 | 48350 | 21530 | 29504637 |
Nodal rhythm | 12.50 | 10.77 | 13 | 48347 | 1307 | 29524860 |
Ischaemic hepatitis | 12.48 | 10.77 | 14 | 48346 | 1534 | 29524633 |
Full blood count abnormal | 12.35 | 10.77 | 53 | 48307 | 14960 | 29511207 |
Anticoagulation drug level above therapeutic | 12.17 | 10.77 | 15 | 48345 | 1816 | 29524351 |
Injury | 11.84 | 10.77 | 62 | 48298 | 18984 | 29507183 |
Inner ear disorder | 11.81 | 10.77 | 6 | 48354 | 193 | 29525974 |
Heart rate increased | 11.72 | 10.77 | 106 | 48254 | 38832 | 29487335 |
Ear congestion | 11.53 | 10.77 | 8 | 48352 | 461 | 29525706 |
Bronchopulmonary aspergillosis | 11.47 | 10.77 | 3 | 48357 | 12341 | 29513826 |
Arrhythmia | 11.42 | 10.77 | 89 | 48271 | 31224 | 29494943 |
Bladder pain | 11.39 | 10.77 | 8 | 48352 | 470 | 29525697 |
Emotional distress | 11.39 | 10.77 | 49 | 48311 | 13846 | 29512321 |
Anal haemorrhage | 11.35 | 10.77 | 15 | 48345 | 1947 | 29524220 |
Skin tightness | 11.33 | 10.77 | 15 | 48345 | 1949 | 29524218 |
Agranulocytosis | 11.25 | 10.77 | 10 | 48350 | 20330 | 29505837 |
Intentional product use issue | 11.20 | 10.77 | 34 | 48326 | 42464 | 29483703 |
Myxoedema | 11.07 | 10.77 | 3 | 48357 | 14 | 29526153 |
Occupational exposure to air contaminants | 11.00 | 10.77 | 5 | 48355 | 125 | 29526042 |
Sports injury | 10.93 | 10.77 | 5 | 48355 | 127 | 29526040 |
Bulbar palsy | 10.78 | 10.77 | 6 | 48354 | 233 | 29525934 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 571.02 | 10.09 | 1280 | 119216 | 223134 | 64155102 |
Atrial fibrillation | 515.94 | 10.09 | 1046 | 119450 | 170043 | 64208193 |
Sedation complication | 399.13 | 10.09 | 246 | 120250 | 10108 | 64368128 |
Creatinine renal clearance decreased | 386.41 | 10.09 | 273 | 120223 | 14148 | 64364088 |
Cardiac failure congestive | 349.83 | 10.09 | 761 | 119735 | 129819 | 64248417 |
Hypotension | 337.89 | 10.09 | 1507 | 118989 | 379467 | 63998769 |
Bradycardia | 328.15 | 10.09 | 699 | 119797 | 117520 | 64260716 |
Orthostatic hypotension | 275.40 | 10.09 | 386 | 120110 | 46352 | 64331884 |
Off label use | 253.02 | 10.09 | 501 | 119995 | 632305 | 63745931 |
Blood calcium decreased | 235.42 | 10.09 | 264 | 120232 | 25290 | 64352946 |
Balance disorder | 209.82 | 10.09 | 476 | 120020 | 83450 | 64294786 |
Sedation | 198.99 | 10.09 | 311 | 120185 | 41151 | 64337085 |
Cognitive disorder | 188.99 | 10.09 | 356 | 120140 | 54731 | 64323505 |
Dyspnoea | 173.20 | 10.09 | 2075 | 118421 | 716599 | 63661637 |
Drug ineffective | 168.18 | 10.09 | 905 | 119591 | 839342 | 63538894 |
Neutropenia | 140.72 | 10.09 | 144 | 120352 | 239480 | 64138756 |
Febrile neutropenia | 139.85 | 10.09 | 89 | 120407 | 187568 | 64190668 |
Fall | 128.46 | 10.09 | 1265 | 119231 | 415561 | 63962675 |
Depressed level of consciousness | 122.04 | 10.09 | 382 | 120114 | 81054 | 64297182 |
Toxicity to various agents | 121.27 | 10.09 | 1122 | 119374 | 362391 | 64015845 |
Synovitis | 120.73 | 10.09 | 20 | 120476 | 99070 | 64279166 |
Maternal exposure during pregnancy | 119.88 | 10.09 | 18 | 120478 | 95866 | 64282370 |
Suspected suicide | 107.65 | 10.09 | 105 | 120391 | 8549 | 64369687 |
Fluid retention | 103.90 | 10.09 | 295 | 120201 | 59311 | 64318925 |
Chronic obstructive pulmonary disease | 100.72 | 10.09 | 327 | 120169 | 70721 | 64307515 |
Dyspnoea exertional | 97.98 | 10.09 | 332 | 120164 | 73398 | 64304838 |
Pulmonary arterial hypertension | 90.80 | 10.09 | 167 | 120329 | 25200 | 64353036 |
Pemphigus | 86.95 | 10.09 | 7 | 120489 | 60694 | 64317542 |
Therapeutic product effect decreased | 86.87 | 10.09 | 54 | 120442 | 115297 | 64262939 |
Atrioventricular block complete | 86.26 | 10.09 | 120 | 120376 | 14298 | 64363938 |
Hand deformity | 85.21 | 10.09 | 9 | 120487 | 62762 | 64315474 |
Chest pain | 85.02 | 10.09 | 741 | 119755 | 235239 | 64142997 |
Treatment failure | 82.17 | 10.09 | 59 | 120437 | 116757 | 64261479 |
Myocardial infarction | 79.82 | 10.09 | 557 | 119939 | 165264 | 64212972 |
Exposure during pregnancy | 77.99 | 10.09 | 24 | 120472 | 77651 | 64300585 |
Product use in unapproved indication | 76.27 | 10.09 | 133 | 120363 | 176485 | 64201751 |
BRASH syndrome | 75.82 | 10.09 | 28 | 120468 | 349 | 64377887 |
Systemic lupus erythematosus rash | 73.78 | 10.09 | 41 | 120455 | 1384 | 64376852 |
Atrial flutter | 72.42 | 10.09 | 130 | 120366 | 19250 | 64358986 |
General physical health deterioration | 72.09 | 10.09 | 173 | 120323 | 204252 | 64173984 |
Pericarditis | 71.05 | 10.09 | 15 | 120481 | 62501 | 64315735 |
Product use issue | 70.40 | 10.09 | 109 | 120387 | 151606 | 64226630 |
Nerve injury | 70.09 | 10.09 | 79 | 120417 | 7606 | 64370630 |
Pyrexia | 69.92 | 10.09 | 687 | 119809 | 557957 | 63820279 |
Coronary artery disease | 69.88 | 10.09 | 260 | 120236 | 60173 | 64318063 |
Drug intolerance | 69.58 | 10.09 | 155 | 120341 | 187837 | 64190399 |
Heart rate increased | 68.81 | 10.09 | 365 | 120131 | 98310 | 64279926 |
Gastrointestinal haemorrhage | 68.16 | 10.09 | 452 | 120044 | 131860 | 64246376 |
Cardiogenic shock | 68.12 | 10.09 | 172 | 120324 | 32255 | 64345981 |
Rheumatoid arthritis | 68.00 | 10.09 | 127 | 120369 | 164167 | 64214069 |
Cardiac arrest | 67.50 | 10.09 | 506 | 119990 | 153558 | 64224678 |
Atrioventricular block second degree | 65.19 | 10.09 | 70 | 120426 | 6384 | 64371852 |
Arthropathy | 65.11 | 10.09 | 78 | 120418 | 120889 | 64257347 |
Mobility decreased | 64.34 | 10.09 | 324 | 120172 | 85516 | 64292720 |
Constipation | 61.90 | 10.09 | 678 | 119818 | 228659 | 64149577 |
Joint swelling | 60.65 | 10.09 | 203 | 120293 | 215179 | 64163057 |
Thrombocytopenia | 60.28 | 10.09 | 215 | 120281 | 223586 | 64154650 |
Respiratory tract congestion | 59.85 | 10.09 | 108 | 120388 | 16057 | 64362179 |
Infusion related reaction | 59.72 | 10.09 | 137 | 120359 | 164330 | 64213906 |
Labile blood pressure | 59.50 | 10.09 | 41 | 120455 | 2039 | 64376197 |
Rash | 57.69 | 10.09 | 563 | 119933 | 457986 | 63920250 |
Malignant neoplasm progression | 57.38 | 10.09 | 76 | 120420 | 112795 | 64265441 |
Hepatic enzyme increased | 56.86 | 10.09 | 97 | 120399 | 129846 | 64248390 |
Oedema peripheral | 55.93 | 10.09 | 620 | 119876 | 209697 | 64168539 |
Dizziness | 55.83 | 10.09 | 1120 | 119376 | 429043 | 63949193 |
Pancytopenia | 55.65 | 10.09 | 115 | 120381 | 143194 | 64235042 |
Atrioventricular block first degree | 54.97 | 10.09 | 83 | 120413 | 10651 | 64367585 |
Alopecia | 53.94 | 10.09 | 146 | 120350 | 165544 | 64212692 |
Asthma | 53.77 | 10.09 | 333 | 120163 | 94892 | 64283344 |
Atrioventricular block | 53.33 | 10.09 | 87 | 120409 | 11928 | 64366308 |
Body tinea | 53.10 | 10.09 | 32 | 120464 | 1261 | 64376975 |
Duodenal ulcer perforation | 52.49 | 10.09 | 3 | 120493 | 34622 | 64343614 |
Angina pectoris | 52.15 | 10.09 | 194 | 120302 | 44887 | 64333349 |
Palpitations | 50.84 | 10.09 | 352 | 120144 | 104136 | 64274100 |
Glossodynia | 50.51 | 10.09 | 29 | 120467 | 64667 | 64313569 |
Cerebrovascular accident | 49.99 | 10.09 | 433 | 120063 | 137150 | 64241086 |
Bunion operation | 49.98 | 10.09 | 26 | 120470 | 767 | 64377469 |
Nodal rhythm | 49.77 | 10.09 | 42 | 120454 | 2832 | 64375404 |
Hypoxia | 49.60 | 10.09 | 308 | 120188 | 87841 | 64290395 |
Discomfort | 49.26 | 10.09 | 47 | 120449 | 80831 | 64297405 |
Inhibitory drug interaction | 48.88 | 10.09 | 46 | 120450 | 3581 | 64374655 |
Contraindicated product administered | 48.56 | 10.09 | 79 | 120417 | 107750 | 64270486 |
Incision site pain | 48.48 | 10.09 | 40 | 120456 | 2614 | 64375622 |
Neutrophil count decreased | 48.03 | 10.09 | 44 | 120452 | 77152 | 64301084 |
White blood cell count decreased | 46.34 | 10.09 | 146 | 120350 | 157691 | 64220545 |
Death | 45.58 | 10.09 | 1202 | 119294 | 481503 | 63896733 |
Stomatitis | 44.22 | 10.09 | 86 | 120410 | 109519 | 64268717 |
Nephrolithiasis | 44.03 | 10.09 | 180 | 120316 | 43503 | 64334733 |
Injection site erythema | 43.28 | 10.09 | 41 | 120455 | 70759 | 64307477 |
Intentional product use issue | 42.81 | 10.09 | 70 | 120426 | 95294 | 64282942 |
Urinary tract discomfort | 42.73 | 10.09 | 18 | 120478 | 324 | 64377912 |
Pain in jaw | 42.73 | 10.09 | 170 | 120326 | 40585 | 64337651 |
Alveolitis | 42.60 | 10.09 | 43 | 120453 | 3649 | 64374587 |
Leukopenia | 42.10 | 10.09 | 78 | 120418 | 101164 | 64277072 |
Pericardial haemorrhage | 42.02 | 10.09 | 45 | 120451 | 4091 | 64374145 |
Systemic lupus erythematosus | 41.80 | 10.09 | 50 | 120446 | 77562 | 64300674 |
Pulmonary congestion | 41.41 | 10.09 | 118 | 120378 | 23762 | 64354474 |
Full blood count abnormal | 40.40 | 10.09 | 135 | 120361 | 29622 | 64348614 |
Medication error | 39.85 | 10.09 | 192 | 120304 | 49774 | 64328462 |
Musculoskeletal stiffness | 39.76 | 10.09 | 109 | 120387 | 123097 | 64255139 |
Hunger | 39.03 | 10.09 | 44 | 120452 | 4237 | 64373999 |
Mucosal inflammation | 38.54 | 10.09 | 36 | 120460 | 62548 | 64315688 |
Cardiac disorder | 37.89 | 10.09 | 205 | 120291 | 55611 | 64322625 |
Unevaluable event | 36.72 | 10.09 | 189 | 120307 | 50300 | 64327936 |
Wound | 36.37 | 10.09 | 54 | 120442 | 76423 | 64301813 |
Hypervolaemia | 35.66 | 10.09 | 154 | 120342 | 38131 | 64340105 |
Heart rate decreased | 35.21 | 10.09 | 199 | 120297 | 54868 | 64323368 |
Foot deformity | 35.14 | 10.09 | 88 | 120408 | 16416 | 64361820 |
Limb injury | 34.94 | 10.09 | 110 | 120386 | 23395 | 64354841 |
Productive cough | 34.65 | 10.09 | 245 | 120251 | 72958 | 64305278 |
Infection susceptibility increased | 33.76 | 10.09 | 33 | 120463 | 2693 | 64375543 |
Drug resistance | 33.21 | 10.09 | 12 | 120484 | 35090 | 64343146 |
Therapeutic product effect incomplete | 33.05 | 10.09 | 92 | 120404 | 103390 | 64274846 |
Alveolar osteitis | 32.96 | 10.09 | 16 | 120480 | 406 | 64377830 |
Muscle relaxant therapy | 31.50 | 10.09 | 12 | 120484 | 164 | 64378072 |
Bladder prolapse | 31.49 | 10.09 | 22 | 120474 | 1119 | 64377117 |
Ill-defined disorder | 31.29 | 10.09 | 22 | 120474 | 44030 | 64334206 |
Hepatic ischaemia | 31.26 | 10.09 | 21 | 120475 | 1001 | 64377235 |
Conjunctivitis allergic | 31.12 | 10.09 | 21 | 120475 | 1009 | 64377227 |
Pulmonary hypertension | 30.34 | 10.09 | 160 | 120336 | 42979 | 64335257 |
Nodal arrhythmia | 30.01 | 10.09 | 26 | 120470 | 1817 | 64376419 |
C-reactive protein increased | 29.85 | 10.09 | 85 | 120411 | 94824 | 64283412 |
Chondrocalcinosis | 29.81 | 10.09 | 18 | 120478 | 712 | 64377524 |
Angina unstable | 29.36 | 10.09 | 79 | 120417 | 15388 | 64362848 |
Transfusion | 29.36 | 10.09 | 87 | 120409 | 17907 | 64360329 |
Oedema | 28.65 | 10.09 | 280 | 120216 | 91655 | 64286581 |
Abortion spontaneous | 28.63 | 10.09 | 6 | 120490 | 25137 | 64353099 |
Oxygen saturation decreased | 28.47 | 10.09 | 316 | 120180 | 106860 | 64271376 |
Prinzmetal angina | 28.18 | 10.09 | 23 | 120473 | 1480 | 64376756 |
Blood pressure systolic increased | 27.94 | 10.09 | 173 | 120323 | 49280 | 64328956 |
Kidney infection | 27.93 | 10.09 | 85 | 120411 | 17753 | 64360483 |
Syncope | 27.72 | 10.09 | 431 | 120065 | 157204 | 64221032 |
Bronchitis | 27.70 | 10.09 | 318 | 120178 | 108425 | 64269811 |
Heart sounds | 27.58 | 10.09 | 16 | 120480 | 587 | 64377649 |
Myopathy | 27.45 | 10.09 | 84 | 120412 | 17596 | 64360640 |
Hyperkalaemia | 27.24 | 10.09 | 299 | 120197 | 100830 | 64277406 |
Status epilepticus | 27.22 | 10.09 | 4 | 120492 | 21659 | 64356577 |
Muscle injury | 26.83 | 10.09 | 8 | 120488 | 26429 | 64351807 |
Poor quality sleep | 26.64 | 10.09 | 87 | 120409 | 18864 | 64359372 |
Paranasal sinus discomfort | 26.36 | 10.09 | 31 | 120465 | 3124 | 64375112 |
Cardioplegia | 26.23 | 10.09 | 6 | 120490 | 9 | 64378227 |
Helicobacter infection | 26.15 | 10.09 | 20 | 120476 | 38342 | 64339894 |
International normalised ratio increased | 26.09 | 10.09 | 244 | 120252 | 78923 | 64299313 |
Bezoar | 26.04 | 10.09 | 26 | 120470 | 2177 | 64376059 |
Pregnancy | 25.88 | 10.09 | 4 | 120492 | 20861 | 64357375 |
Tunnel vision | 25.86 | 10.09 | 19 | 120477 | 1046 | 64377190 |
Intentional self-injury | 25.71 | 10.09 | 11 | 120485 | 29033 | 64349203 |
Distributive shock | 25.69 | 10.09 | 24 | 120472 | 1851 | 64376385 |
Spirometry abnormal | 25.60 | 10.09 | 15 | 120481 | 561 | 64377675 |
Atrial thrombosis | 25.60 | 10.09 | 30 | 120466 | 3012 | 64375224 |
Drug interaction | 25.53 | 10.09 | 870 | 119626 | 361213 | 64017023 |
Hepatic function abnormal | 25.47 | 10.09 | 51 | 120445 | 64262 | 64313974 |
Aortic stenosis | 25.47 | 10.09 | 44 | 120452 | 6321 | 64371915 |
Prolonged expiration | 25.39 | 10.09 | 17 | 120479 | 806 | 64377430 |
Lower gastrointestinal haemorrhage | 25.27 | 10.09 | 70 | 120426 | 13869 | 64364367 |
Erythrodermic psoriasis | 25.16 | 10.09 | 22 | 120474 | 1557 | 64376679 |
Antiacetylcholine receptor antibody positive | 25.15 | 10.09 | 8 | 120488 | 61 | 64378175 |
Bladder pain | 24.80 | 10.09 | 23 | 120473 | 1758 | 64376478 |
Agranulocytosis | 24.73 | 10.09 | 21 | 120475 | 38208 | 64340028 |
Pacemaker generated rhythm | 24.71 | 10.09 | 8 | 120488 | 65 | 64378171 |
Heart rate irregular | 24.56 | 10.09 | 109 | 120387 | 27304 | 64350932 |
Suicidal ideation | 24.48 | 10.09 | 55 | 120441 | 66487 | 64311749 |
Nasal congestion | 24.46 | 10.09 | 193 | 120303 | 59465 | 64318771 |
Cough | 24.42 | 10.09 | 738 | 119758 | 301410 | 64076826 |
Injection site pruritus | 24.19 | 10.09 | 21 | 120475 | 37805 | 64340431 |
Folliculitis | 24.17 | 10.09 | 13 | 120483 | 30064 | 64348172 |
Blood iron decreased | 24.04 | 10.09 | 63 | 120433 | 12079 | 64366157 |
Pneumonia | 23.97 | 10.09 | 1276 | 119220 | 558300 | 63819936 |
Erythromelalgia | 23.79 | 10.09 | 10 | 120486 | 179 | 64378057 |
Aspartate aminotransferase increased | 23.76 | 10.09 | 129 | 120367 | 119659 | 64258577 |
Alanine aminotransferase increased | 23.74 | 10.09 | 157 | 120339 | 138874 | 64239362 |
Bone marrow failure | 23.64 | 10.09 | 33 | 120463 | 47919 | 64330317 |
Gastrointestinal disorder | 23.58 | 10.09 | 87 | 120409 | 89622 | 64288614 |
Supraventricular tachycardia | 23.24 | 10.09 | 83 | 120413 | 18824 | 64359412 |
Blue toe syndrome | 22.95 | 10.09 | 14 | 120482 | 564 | 64377672 |
Bronchopulmonary aspergillosis | 22.91 | 10.09 | 4 | 120492 | 19081 | 64359155 |
Asthenia | 22.72 | 10.09 | 997 | 119499 | 427047 | 63951189 |
Mite allergy | 22.46 | 10.09 | 15 | 120481 | 708 | 64377528 |
Arthralgia | 22.40 | 10.09 | 642 | 119854 | 441618 | 63936618 |
Impaired quality of life | 22.40 | 10.09 | 42 | 120454 | 6429 | 64371807 |
Septic shock | 22.34 | 10.09 | 111 | 120385 | 105326 | 64272910 |
Pulmonary oedema | 22.30 | 10.09 | 235 | 120261 | 78439 | 64299797 |
Wrong technique in product usage process | 22.08 | 10.09 | 56 | 120440 | 64918 | 64313318 |
Abdominal pain | 22.05 | 10.09 | 431 | 120065 | 311944 | 64066292 |
Neutropenic sepsis | 21.94 | 10.09 | 8 | 120488 | 23264 | 64354972 |
Forced expiratory volume decreased | 21.84 | 10.09 | 43 | 120453 | 6824 | 64371412 |
Arterial spasm | 21.84 | 10.09 | 9 | 120487 | 153 | 64378083 |
Platelet count decreased | 21.83 | 10.09 | 204 | 120292 | 167507 | 64210729 |
Coronary artery bypass | 21.72 | 10.09 | 39 | 120457 | 5776 | 64372460 |
Aggression | 21.63 | 10.09 | 33 | 120463 | 46199 | 64332037 |
Rectal prolapse | 21.57 | 10.09 | 21 | 120475 | 1705 | 64376531 |
Neuroleptic malignant syndrome | 21.29 | 10.09 | 10 | 120486 | 24986 | 64353250 |
Vasoplegia syndrome | 21.17 | 10.09 | 26 | 120470 | 2741 | 64375495 |
Abnormal behaviour | 21.10 | 10.09 | 19 | 120477 | 33603 | 64344633 |
Cytomegalovirus infection | 21.07 | 10.09 | 23 | 120473 | 37176 | 64341060 |
Arteriovenous fistula occlusion | 21.04 | 10.09 | 13 | 120483 | 536 | 64377700 |
Coagulopathy | 20.83 | 10.09 | 116 | 120380 | 31804 | 64346432 |
Sopor | 20.82 | 10.09 | 15 | 120481 | 29646 | 64348590 |
Pneumocystis jirovecii pneumonia | 20.70 | 10.09 | 13 | 120483 | 27621 | 64350615 |
Blood loss anaemia | 20.64 | 10.09 | 65 | 120431 | 13827 | 64364409 |
Disturbance in attention | 20.52 | 10.09 | 28 | 120468 | 41046 | 64337190 |
Cardiac pacemaker insertion | 20.46 | 10.09 | 35 | 120461 | 4988 | 64373248 |
Animal scratch | 20.33 | 10.09 | 16 | 120480 | 977 | 64377259 |
Mycotic allergy | 20.26 | 10.09 | 16 | 120480 | 982 | 64377254 |
Sleep disorder due to general medical condition, insomnia type | 20.18 | 10.09 | 12 | 120484 | 26258 | 64351978 |
Glucose tolerance impaired | 20.08 | 10.09 | 40 | 120456 | 6403 | 64371833 |
Posterior reversible encephalopathy syndrome | 19.82 | 10.09 | 9 | 120487 | 22937 | 64355299 |
Gastrooesophageal reflux disease | 19.78 | 10.09 | 240 | 120256 | 82903 | 64295333 |
Rales | 19.71 | 10.09 | 68 | 120428 | 15161 | 64363075 |
Urticaria | 19.69 | 10.09 | 178 | 120318 | 147139 | 64231097 |
Peak expiratory flow rate abnormal | 19.66 | 10.09 | 7 | 120489 | 78 | 64378158 |
Myelosuppression | 19.59 | 10.09 | 10 | 120486 | 23820 | 64354416 |
Dust allergy | 19.50 | 10.09 | 16 | 120480 | 1037 | 64377199 |
Blood pressure diastolic decreased | 19.47 | 10.09 | 88 | 120408 | 22213 | 64356023 |
Disease progression | 19.46 | 10.09 | 170 | 120326 | 141510 | 64236726 |
Ear congestion | 19.43 | 10.09 | 22 | 120474 | 2128 | 64376108 |
Aortic arteriosclerosis | 19.33 | 10.09 | 43 | 120453 | 7433 | 64370803 |
Psoriatic arthropathy | 19.21 | 10.09 | 32 | 120464 | 43249 | 64334987 |
Red blood cell sedimentation rate increased | 19.19 | 10.09 | 18 | 120478 | 31217 | 64347019 |
Obstructive airways disorder | 19.14 | 10.09 | 90 | 120406 | 23095 | 64355141 |
Acute myeloid leukaemia | 19.13 | 10.09 | 14 | 120482 | 27449 | 64350787 |
Osteonecrosis of jaw | 19.05 | 10.09 | 28 | 120468 | 39797 | 64338439 |
Liver disorder | 18.90 | 10.09 | 45 | 120451 | 53306 | 64324930 |
Seizure | 18.84 | 10.09 | 210 | 120286 | 166682 | 64211554 |
Hyperbilirubinaemia | 18.82 | 10.09 | 8 | 120488 | 21197 | 64357039 |
Torsade de pointes | 18.66 | 10.09 | 73 | 120423 | 17290 | 64360946 |
Atrioventricular dissociation | 18.62 | 10.09 | 10 | 120486 | 315 | 64377921 |
Vomiting | 18.58 | 10.09 | 841 | 119655 | 550276 | 63827960 |
Aspergillus infection | 18.46 | 10.09 | 4 | 120492 | 16375 | 64361861 |
Haemarthrosis | 18.18 | 10.09 | 34 | 120462 | 5195 | 64373041 |
Gouty tophus | 18.15 | 10.09 | 10 | 120486 | 332 | 64377904 |
Wound complication | 18.08 | 10.09 | 29 | 120467 | 3919 | 64374317 |
Gamma-glutamyltransferase increased | 17.92 | 10.09 | 40 | 120456 | 48470 | 64329766 |
Arrhythmia | 17.86 | 10.09 | 164 | 120332 | 52780 | 64325456 |
Thermal burn | 17.61 | 10.09 | 36 | 120460 | 5870 | 64372366 |
Arrhythmogenic right ventricular dysplasia | 17.51 | 10.09 | 5 | 120491 | 25 | 64378211 |
Respiratory acidosis | 17.38 | 10.09 | 49 | 120447 | 9806 | 64368430 |
Carbon dioxide increased | 17.38 | 10.09 | 20 | 120476 | 1969 | 64376267 |
Presyncope | 16.93 | 10.09 | 118 | 120378 | 34971 | 64343265 |
Psychotic disorder | 16.84 | 10.09 | 24 | 120472 | 34554 | 64343682 |
Renal pain | 16.79 | 10.09 | 39 | 120457 | 6935 | 64371301 |
Feeling cold | 16.77 | 10.09 | 88 | 120408 | 23590 | 64354646 |
Myocardial hypoxia | 16.76 | 10.09 | 4 | 120492 | 8 | 64378228 |
Toxic optic neuropathy | 16.73 | 10.09 | 14 | 120482 | 933 | 64377303 |
Muscle strain | 16.72 | 10.09 | 43 | 120453 | 8151 | 64370085 |
Haemophagocytic lymphohistiocytosis | 16.69 | 10.09 | 6 | 120490 | 17603 | 64360633 |
Epilepsy | 16.60 | 10.09 | 23 | 120473 | 33508 | 64344728 |
Heart rate abnormal | 16.59 | 10.09 | 32 | 120464 | 5003 | 64373233 |
Blood urine present | 16.49 | 10.09 | 73 | 120423 | 18267 | 64359969 |
Hepatotoxicity | 16.42 | 10.09 | 31 | 120465 | 39931 | 64338305 |
Liver injury | 16.42 | 10.09 | 19 | 120477 | 29913 | 64348323 |
Irritable bowel syndrome | 16.24 | 10.09 | 28 | 120468 | 37341 | 64340895 |
Oxygen consumption increased | 16.19 | 10.09 | 30 | 120466 | 4551 | 64373685 |
Nephroangiosclerosis | 16.14 | 10.09 | 9 | 120487 | 306 | 64377930 |
Dysphagia | 16.10 | 10.09 | 125 | 120371 | 106687 | 64271549 |
Injection site pain | 16.05 | 10.09 | 132 | 120364 | 111276 | 64266960 |
Hyperlipidaemia | 16.01 | 10.09 | 85 | 120411 | 22891 | 64355345 |
Anaphylactic reaction | 15.89 | 10.09 | 70 | 120426 | 68594 | 64309642 |
Sepsis | 15.88 | 10.09 | 319 | 120177 | 230022 | 64148214 |
Renal injury | 15.88 | 10.09 | 64 | 120432 | 15365 | 64362871 |
Cardiac ablation | 15.79 | 10.09 | 18 | 120478 | 1754 | 64376482 |
Blood bilirubin increased | 15.66 | 10.09 | 55 | 120441 | 57498 | 64320738 |
Device pacing issue | 15.49 | 10.09 | 6 | 120490 | 86 | 64378150 |
Red blood cells urine positive | 15.42 | 10.09 | 29 | 120467 | 4449 | 64373787 |
Polyneuropathy | 15.41 | 10.09 | 9 | 120487 | 19885 | 64358351 |
Humidity intolerance | 15.37 | 10.09 | 9 | 120487 | 336 | 64377900 |
Electrocardiogram QRS complex prolonged | 15.37 | 10.09 | 45 | 120451 | 9199 | 64369037 |
Foot operation | 15.30 | 10.09 | 28 | 120468 | 4207 | 64374029 |
Aspiration pleural cavity | 15.27 | 10.09 | 16 | 120480 | 1419 | 64376817 |
Acute lung injury | 15.25 | 10.09 | 22 | 120474 | 2709 | 64375527 |
Ventricular fibrillation | 15.10 | 10.09 | 86 | 120410 | 23774 | 64354462 |
Tendon pain | 14.99 | 10.09 | 30 | 120466 | 4818 | 64373418 |
Premature delivery | 14.99 | 10.09 | 8 | 120488 | 18581 | 64359655 |
Catheter site erythema | 14.98 | 10.09 | 30 | 120466 | 4819 | 64373417 |
Hospitalisation | 14.92 | 10.09 | 210 | 120286 | 74997 | 64303239 |
Catheter site haemorrhage | 14.91 | 10.09 | 29 | 120467 | 4562 | 64373674 |
Cardioversion | 14.89 | 10.09 | 18 | 120478 | 1867 | 64376369 |
Chest discomfort | 14.89 | 10.09 | 302 | 120194 | 115804 | 64262432 |
Myocardial ischaemia | 14.84 | 10.09 | 84 | 120412 | 23167 | 64355069 |
Sinus bradycardia | 14.81 | 10.09 | 83 | 120413 | 22810 | 64355426 |
Cardiac valve disease | 14.71 | 10.09 | 31 | 120465 | 5164 | 64373072 |
Polymyalgia rheumatica | 14.47 | 10.09 | 24 | 120472 | 3335 | 64374901 |
Coma | 14.42 | 10.09 | 100 | 120396 | 87515 | 64290721 |
Wheezing | 14.41 | 10.09 | 221 | 120275 | 80358 | 64297878 |
Stent placement | 14.35 | 10.09 | 32 | 120464 | 5539 | 64372697 |
Pulmonary function test decreased | 14.33 | 10.09 | 35 | 120461 | 6426 | 64371810 |
Multiple sclerosis relapse | 14.33 | 10.09 | 35 | 120461 | 41100 | 64337136 |
Disseminated intravascular coagulation | 14.28 | 10.09 | 24 | 120472 | 32324 | 64345912 |
Eczema infected | 14.18 | 10.09 | 5 | 120491 | 54 | 64378182 |
Renal failure | 14.18 | 10.09 | 442 | 120054 | 181246 | 64196990 |
Sebaceous gland infection | 14.14 | 10.09 | 6 | 120490 | 110 | 64378126 |
Interstitial lung disease | 13.98 | 10.09 | 116 | 120380 | 97616 | 64280620 |
Drug reaction with eosinophilia and systemic symptoms | 13.97 | 10.09 | 53 | 120443 | 54164 | 64324072 |
Fibrous histiocytoma | 13.96 | 10.09 | 10 | 120486 | 529 | 64377707 |
Cardioactive drug level increased | 13.92 | 10.09 | 24 | 120472 | 3441 | 64374795 |
Electrocardiogram U wave present | 13.85 | 10.09 | 6 | 120490 | 116 | 64378120 |
Tooth infection | 13.80 | 10.09 | 59 | 120437 | 14542 | 64363694 |
Inflammation | 13.68 | 10.09 | 69 | 120427 | 65231 | 64313005 |
Bronchopulmonary aspergillosis allergic | 13.65 | 10.09 | 16 | 120480 | 1606 | 64376630 |
Skin laceration | 13.53 | 10.09 | 85 | 120411 | 24332 | 64353904 |
Metastases to bone | 13.49 | 10.09 | 11 | 120485 | 20424 | 64357812 |
Mast cell degranulation present | 13.49 | 10.09 | 5 | 120491 | 63 | 64378173 |
Pruritus | 13.49 | 10.09 | 463 | 120033 | 311937 | 64066299 |
Neoplasm progression | 13.39 | 10.09 | 36 | 120460 | 40928 | 64337308 |
Vitamin D decreased | 13.34 | 10.09 | 38 | 120458 | 7649 | 64370587 |
Serotonin syndrome | 13.23 | 10.09 | 34 | 120462 | 39248 | 64338988 |
Confusional state | 13.22 | 10.09 | 379 | 120117 | 260765 | 64117471 |
Gallbladder polyp | 13.13 | 10.09 | 12 | 120484 | 900 | 64377336 |
Progressive multifocal leukoencephalopathy | 13.09 | 10.09 | 9 | 120487 | 18223 | 64360013 |
Palmar-plantar erythrodysaesthesia syndrome | 13.07 | 10.09 | 21 | 120475 | 28798 | 64349438 |
Ventricular tachycardia | 13.04 | 10.09 | 109 | 120387 | 34156 | 64344080 |
Restlessness | 12.97 | 10.09 | 35 | 120461 | 39750 | 64338486 |
Weight decreased | 12.88 | 10.09 | 655 | 119841 | 285084 | 64093152 |
Tetany | 12.87 | 10.09 | 18 | 120478 | 2154 | 64376082 |
Rectal haemorrhage | 12.82 | 10.09 | 174 | 120322 | 61643 | 64316593 |
Neuropathy peripheral | 12.82 | 10.09 | 149 | 120347 | 117376 | 64260860 |
Myocarditis | 12.79 | 10.09 | 8 | 120488 | 17035 | 64361201 |
Colon gangrene | 12.75 | 10.09 | 4 | 120492 | 29 | 64378207 |
Suicide attempt | 12.72 | 10.09 | 79 | 120417 | 70928 | 64307308 |
Altered state of consciousness | 12.62 | 10.09 | 33 | 120463 | 37869 | 64340367 |
Hepatorenal syndrome | 12.58 | 10.09 | 24 | 120472 | 3722 | 64374514 |
Sleep disorder | 12.57 | 10.09 | 63 | 120433 | 59646 | 64318590 |
Arteriospasm coronary | 12.55 | 10.09 | 30 | 120466 | 5435 | 64372801 |
Inappropriate schedule of product administration | 12.55 | 10.09 | 111 | 120385 | 92175 | 64286061 |
Injection site inflammation | 12.54 | 10.09 | 22 | 120474 | 3199 | 64375037 |
Bradyarrhythmia | 12.52 | 10.09 | 24 | 120472 | 3734 | 64374502 |
Incision site haemorrhage | 12.52 | 10.09 | 12 | 120484 | 956 | 64377280 |
Protein urine present | 12.48 | 10.09 | 41 | 120455 | 8915 | 64369321 |
Embolic stroke | 12.46 | 10.09 | 34 | 120462 | 6677 | 64371559 |
Catheter site discharge | 12.44 | 10.09 | 18 | 120478 | 2223 | 64376013 |
Anuria | 12.43 | 10.09 | 69 | 120427 | 18895 | 64359341 |
Encephalitis | 12.41 | 10.09 | 4 | 120492 | 12567 | 64365669 |
Sinoatrial block | 12.40 | 10.09 | 13 | 120483 | 1153 | 64377083 |
Histoplasmosis | 12.35 | 10.09 | 17 | 120479 | 2005 | 64376231 |
Ectopic ACTH syndrome | 12.33 | 10.09 | 6 | 120490 | 153 | 64378083 |
Pain in extremity | 12.31 | 10.09 | 688 | 119808 | 302397 | 64075839 |
Coronary artery occlusion | 12.27 | 10.09 | 55 | 120441 | 13836 | 64364400 |
Muscle disorder | 12.27 | 10.09 | 28 | 120468 | 4923 | 64373313 |
Ventricular arrhythmia | 12.24 | 10.09 | 36 | 120460 | 7379 | 64370857 |
Enlarged uvula | 12.20 | 10.09 | 8 | 120488 | 366 | 64377870 |
Pulmonary embolism | 12.20 | 10.09 | 196 | 120300 | 146160 | 64232076 |
Oxygen therapy | 12.12 | 10.09 | 18 | 120478 | 2275 | 64375961 |
Brain oedema | 12.12 | 10.09 | 14 | 120482 | 22061 | 64356175 |
Live birth | 12.11 | 10.09 | 3 | 120493 | 11201 | 64367035 |
Sinus node dysfunction | 12.09 | 10.09 | 34 | 120462 | 6794 | 64371442 |
Drug hypersensitivity | 12.07 | 10.09 | 345 | 120151 | 237470 | 64140766 |
Schizophrenia | 12.05 | 10.09 | 3 | 120493 | 11165 | 64367071 |
Iron deficiency anaemia | 12.00 | 10.09 | 76 | 120420 | 21813 | 64356423 |
Acute generalised exanthematous pustulosis | 11.92 | 10.09 | 55 | 120441 | 14003 | 64364233 |
Catheter site pain | 11.91 | 10.09 | 26 | 120470 | 4436 | 64373800 |
Sinus arrest | 11.89 | 10.09 | 21 | 120475 | 3069 | 64375167 |
Catheter management | 11.89 | 10.09 | 22 | 120474 | 3333 | 64374903 |
Eosinophilic pleural effusion | 11.85 | 10.09 | 7 | 120489 | 266 | 64377970 |
Sinus pain | 11.83 | 10.09 | 19 | 120477 | 2570 | 64375666 |
Mitral valve incompetence | 11.80 | 10.09 | 85 | 120411 | 25453 | 64352783 |
Coronary arterial stent insertion | 11.75 | 10.09 | 30 | 120466 | 5662 | 64372574 |
Anion gap abnormal | 11.71 | 10.09 | 9 | 120487 | 531 | 64377705 |
Shock | 11.68 | 10.09 | 116 | 120380 | 38124 | 64340112 |
Cardiac failure | 11.68 | 10.09 | 327 | 120169 | 132046 | 64246190 |
Cytokine release syndrome | 11.66 | 10.09 | 13 | 120483 | 20816 | 64357420 |
Gravitational oedema | 11.66 | 10.09 | 15 | 120481 | 1657 | 64376579 |
Stupor | 11.63 | 10.09 | 31 | 120465 | 6004 | 64372232 |
Blister | 11.63 | 10.09 | 96 | 120400 | 80871 | 64297365 |
Generalised tonic-clonic seizure | 11.59 | 10.09 | 37 | 120459 | 39820 | 64338416 |
Peritonitis | 11.57 | 10.09 | 18 | 120478 | 25005 | 64353231 |
Seasonal allergy | 11.56 | 10.09 | 48 | 120448 | 11678 | 64366558 |
Cholangitis | 11.46 | 10.09 | 3 | 120493 | 10799 | 64367437 |
Drug abuse | 11.46 | 10.09 | 176 | 120320 | 132198 | 64246038 |
Bladder disorder | 11.22 | 10.09 | 36 | 120460 | 7731 | 64370505 |
Coronary artery restenosis | 11.22 | 10.09 | 13 | 120483 | 1289 | 64376947 |
Aplastic anaemia | 11.21 | 10.09 | 6 | 120490 | 13914 | 64364322 |
Metastases to central nervous system | 11.20 | 10.09 | 6 | 120490 | 13906 | 64364330 |
Erythema | 11.18 | 10.09 | 265 | 120231 | 186805 | 64191431 |
Extrapyramidal disorder | 11.17 | 10.09 | 12 | 120484 | 19540 | 64358696 |
Orthopnoea | 11.14 | 10.09 | 40 | 120456 | 9094 | 64369142 |
Influenza virus test positive | 11.13 | 10.09 | 7 | 120489 | 298 | 64377938 |
Bronchiectasis | 11.03 | 10.09 | 54 | 120442 | 14086 | 64364150 |
Infusion site erythema | 10.99 | 10.09 | 33 | 120463 | 6840 | 64371396 |
Acute respiratory failure | 10.96 | 10.09 | 142 | 120354 | 49792 | 64328444 |
Pulseless electrical activity | 10.92 | 10.09 | 50 | 120446 | 12689 | 64365547 |
Jaundice | 10.90 | 10.09 | 50 | 120446 | 48462 | 64329774 |
Emotional distress | 10.85 | 10.09 | 109 | 120387 | 35929 | 64342307 |
Urticarial vasculitis | 10.85 | 10.09 | 8 | 120488 | 443 | 64377793 |
Deep vein thrombosis | 10.84 | 10.09 | 135 | 120361 | 105047 | 64273189 |
Cellulitis | 10.83 | 10.09 | 240 | 120256 | 93417 | 64284819 |
Right ventricular failure | 10.83 | 10.09 | 73 | 120423 | 21398 | 64356838 |
Leukaemoid reaction | 10.78 | 10.09 | 7 | 120489 | 315 | 64377921 |
COVID-19 pneumonia | 10.75 | 10.09 | 9 | 120487 | 16495 | 64361741 |
Respiration abnormal | 10.75 | 10.09 | 31 | 120465 | 6284 | 64371952 |
Infection | 10.75 | 10.09 | 263 | 120233 | 184617 | 64193619 |
Motion sickness | 10.74 | 10.09 | 10 | 120486 | 768 | 64377468 |
Spondyloarthropathy | 10.65 | 10.09 | 10 | 120486 | 776 | 64377460 |
Transaminases increased | 10.60 | 10.09 | 45 | 120451 | 44549 | 64333687 |
Peripheral swelling | 10.59 | 10.09 | 485 | 120011 | 208668 | 64169568 |
Electrocardiogram QT shortened | 10.55 | 10.09 | 6 | 120490 | 212 | 64378024 |
Arteriosclerosis coronary artery | 10.51 | 10.09 | 57 | 120439 | 15472 | 64362764 |
Lymphopenia | 10.45 | 10.09 | 20 | 120476 | 25637 | 64352599 |
Fear | 10.43 | 10.09 | 69 | 120427 | 20102 | 64358134 |
Febrile bone marrow aplasia | 10.39 | 10.09 | 4 | 120492 | 11251 | 64366985 |
Skin necrosis | 10.38 | 10.09 | 7 | 120489 | 14322 | 64363914 |
Nausea | 10.37 | 10.09 | 1298 | 119198 | 784502 | 63593734 |
Occupational exposure to air contaminants | 10.37 | 10.09 | 5 | 120491 | 125 | 64378111 |
Accidental exposure to product | 10.36 | 10.09 | 21 | 120475 | 26343 | 64351893 |
Perineal pain | 10.34 | 10.09 | 11 | 120485 | 992 | 64377244 |
Depression | 10.31 | 10.09 | 262 | 120234 | 183029 | 64195207 |
Injection site swelling | 10.29 | 10.09 | 41 | 120455 | 41312 | 64336924 |
Injection site urticaria | 10.28 | 10.09 | 4 | 120492 | 11177 | 64367059 |
Mastication disorder | 10.25 | 10.09 | 17 | 120479 | 2362 | 64375874 |
Hallucination, auditory | 10.13 | 10.09 | 10 | 120486 | 16929 | 64361307 |
Ataxia | 10.10 | 10.09 | 16 | 120480 | 22068 | 64356168 |
None
Source | Code | Description |
---|---|---|
ATC | C05AE03 | CARDIOVASCULAR SYSTEM VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Muscle relaxants |
ATC | C08DB01 | CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS Benzothiazepine derivatives |
FDA MoA | N0000000069 | Calcium Channel Antagonists |
FDA EPC | N0000175566 | Calcium Channel Blocker |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002121 | Calcium Channel Blockers |
MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D014665 | Vasodilator Agents |
CHEBI has role | CHEBI:35620 | vasodilator agents |
CHEBI has role | CHEBI:35674 | antihypertensive drugs |
CHEBI has role | CHEBI:38215 | calcium channel blockers |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Atrial fibrillation | indication | 49436004 | DOID:0060224 |
Paroxysmal supraventricular tachycardia | indication | 67198005 | |
Prinzmetal angina | indication | 87343002 | |
Angina pectoris | indication | 194828000 | |
Anal fissure | off-label use | 30037006 | |
Supraventricular arrhythmia | off-label use | 72654001 | |
Diastolic heart failure | off-label use | 418304008 | DOID:9775 |
Hyperkalemia | contraindication | 14140009 | |
Ventricular tachycardia | contraindication | 25569003 | |
Complete atrioventricular block | contraindication | 27885002 | |
Acute cerebrovascular insufficiency | contraindication | 29322000 | |
Sick sinus syndrome | contraindication | 36083008 | DOID:13884 |
Immunosuppression | contraindication | 38013005 | |
Angioedema | contraindication | 41291007 | DOID:1558 |
Low blood pressure | contraindication | 45007003 | |
Bradycardia | contraindication | 48867003 | |
Lown-Ganong-Levine syndrome | contraindication | 55475008 | DOID:13087 |
Aortic valve stenosis | contraindication | 60573004 | DOID:1712 |
Wolff-Parkinson-White pattern | contraindication | 74390002 | DOID:384 |
Transplantation | contraindication | 77465005 | |
Chronic idiopathic constipation | contraindication | 82934008 | |
Hereditary angioneurotic edema | contraindication | 82966003 | DOID:14735 |
Cardiogenic shock | contraindication | 89138009 | |
Hyponatremia | contraindication | 89627008 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disorder of connective tissue | contraindication | 105969002 | DOID:65 |
Second degree atrioventricular block | contraindication | 195042002 | |
Decompensated cardiac failure | contraindication | 195111005 | |
Hypertrophic cardiomyopathy | contraindication | 233873004 | DOID:11984 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Pregnancy, function | contraindication | 289908002 | |
Renal artery stenosis | contraindication | 302233006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Left ventricular cardiac dysfunction | contraindication | 429589006 | |
Hemodialysis with High-Flux Membrane | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 7.63 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Voltage-dependent L-type calcium channel subunit alpha-1C | Ion channel | BLOCKER | IC50 | 7.32 | WOMBAT-PK | CHEMBL | |||
Cytochrome P450 3A4 | Enzyme | IC50 | 5.74 | DRUG MATRIX | |||||
Multidrug resistance protein 1 | Transporter | IC50 | 4.37 | CHEMBL | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 5.62 | PDSP | |||||
5-hydroxytryptamine receptor 3A | Ion channel | BLOCKER | IC50 | 4.68 | IUPHAR | ||||
Voltage-dependent calcium channel gamma-1 subunit | Ion channel | IC50 | 6.10 | WOMBAT-PK | |||||
Voltage-dependent T-type calcium channel subunit alpha-1H | Ion channel | Ki | 4.02 | WOMBAT-PK | |||||
Voltage-dependent L-type calcium channel subunit alpha-1S | Ion channel | Ki | 6.42 | CHEMBL | |||||
Solute carrier family 22 member 1 | Transporter | IC50 | 4.91 | CHEMBL | |||||
Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | IC50 | 4.35 | CHEMBL | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 4.76 | CHEMBL | |||||
Voltage-dependent L-type calcium channel subunit alpha-1C | Ion channel | IC50 | 4.52 | CHEMBL | |||||
Voltage-dependent L-type calcium channel subunit alpha-1C | Ion channel | IC50 | 7.27 | CHEMBL | |||||
Voltage-dependent L-type calcium channel subunit alpha-1D | Ion channel | IC50 | 7.34 | CHEMBL | |||||
5-hydroxytryptamine receptor 3A | Ion channel | BLOCKER | IC50 | 5.26 | IUPHAR | ||||
Voltage-gated L-type calcium channel | Ion channel | Ki | 7.80 | CHEMBL | |||||
Potassium voltage-gated channel subfamily C member 1 | Ion channel | BLOCKER | IC50 | 4 | IUPHAR | ||||
Potassium voltage-gated channel subfamily A member 7 | Ion channel | BLOCKER | IC50 | 4.20 | IUPHAR | ||||
Voltage-dependent L-type calcium channel subunit alpha-1F | Ion channel | BLOCKER | IC50 | 4 | IUPHAR |
ID | Source |
---|---|
4020128 | VUID |
N0000179650 | NUI |
D00616 | KEGG_DRUG |
33286-22-5 | SECONDARY_CAS_RN |
144604-00-2 | SECONDARY_CAS_RN |
203211 | RXNORM |
4018817 | VANDF |
4019722 | VANDF |
4020128 | VANDF |
CHEBI:101278 | CHEBI |
C9F | PDB_CHEM_ID |
CHEMBL23 | ChEMBL_ID |
CHEMBL1697 | ChEMBL_ID |
CHEMBL1200805 | ChEMBL_ID |
2298 | IUPHAR_LIGAND_ID |
3433 | INN_ID |
DB00343 | DRUGBANK_ID |
EE92BBP03H | UNII |
39186 | PUBCHEM_CID |
1547 | MMSL |
4604 | MMSL |
d00045 | MMSL |
000711 | NDDF |
004514 | NDDF |
007237 | NDDF |
12218006 | SNOMEDCT_US |
372793000 | SNOMEDCT_US |
59941008 | SNOMEDCT_US |
D004110 | MESH_DESCRIPTOR_UI |
C0012373 | UMLSCUI |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Diltiazem Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0318 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 18 sections |
Diltiazem Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0319 | TABLET, FILM COATED | 60 mg | ORAL | ANDA | 18 sections |
Diltiazem Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0320 | TABLET, FILM COATED | 90 mg | ORAL | ANDA | 18 sections |
Diltiazem Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0321 | TABLET, FILM COATED | 120 mg | ORAL | ANDA | 18 sections |
Cardizem | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0771 | TABLET, COATED | 30 mg | ORAL | NDA | 21 sections |
Cardizem | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0772 | TABLET, COATED | 60 mg | ORAL | NDA | 21 sections |
Cardizem | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0791 | TABLET, COATED | 90 mg | ORAL | NDA | 21 sections |
Cardizem | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0792 | TABLET, COATED | 120 mg | ORAL | NDA | 21 sections |
Cardizem CD | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0795 | CAPSULE, COATED, EXTENDED RELEASE | 120 mg | ORAL | NDA | 14 sections |
Cardizem CD | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0796 | CAPSULE, COATED, EXTENDED RELEASE | 180 mg | ORAL | NDA | 14 sections |
Cardizem CD | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0797 | CAPSULE, COATED, EXTENDED RELEASE | 240 mg | ORAL | NDA | 14 sections |
Cardizem CD | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0798 | CAPSULE, COATED, EXTENDED RELEASE | 300 mg | ORAL | NDA | 14 sections |
Cardizem CD | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-0799 | CAPSULE, COATED, EXTENDED RELEASE | 360 mg | ORAL | NDA | 14 sections |
Cardizem LA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-2045 | TABLET, EXTENDED RELEASE | 120 mg | ORAL | NDA | 25 sections |
Cardizem LA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-2046 | TABLET, EXTENDED RELEASE | 180 mg | ORAL | NDA | 25 sections |
Cardizem LA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-2047 | TABLET, EXTENDED RELEASE | 240 mg | ORAL | NDA | 25 sections |
Cardizem LA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-2048 | TABLET, EXTENDED RELEASE | 300 mg | ORAL | NDA | 25 sections |
Cardizem LA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-2049 | TABLET, EXTENDED RELEASE | 360 mg | ORAL | NDA | 25 sections |
Cardizem LA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-2050 | TABLET, EXTENDED RELEASE | 420 mg | ORAL | NDA | 25 sections |
TIAZACEXTENDED RELEASE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-2612 | CAPSULE, EXTENDED RELEASE | 120 mg | ORAL | NDA | 23 sections |
TIAZACEXTENDED RELEASE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-2613 | CAPSULE, EXTENDED RELEASE | 180 mg | ORAL | NDA | 23 sections |
TIAZACEXTENDED RELEASE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-2614 | CAPSULE, EXTENDED RELEASE | 240 mg | ORAL | NDA | 23 sections |
TIAZACEXTENDED RELEASE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-2615 | CAPSULE, EXTENDED RELEASE | 300 mg | ORAL | NDA | 23 sections |
TIAZACEXTENDED RELEASE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-2616 | CAPSULE, EXTENDED RELEASE | 360 mg | ORAL | NDA | 23 sections |
TIAZACEXTENDED RELEASE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-2617 | CAPSULE, EXTENDED RELEASE | 420 mg | ORAL | NDA | 23 sections |
Diltiazem Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2918 | CAPSULE, EXTENDED RELEASE | 360 mg | ORAL | ANDA | 20 sections |
Diltiazem Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-6060 | CAPSULE, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 20 sections |
Diltiazem Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-6090 | CAPSULE, EXTENDED RELEASE | 90 mg | ORAL | ANDA | 20 sections |
Diltiazem Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-6120 | CAPSULE, EXTENDED RELEASE | 120 mg | ORAL | ANDA | 20 sections |
Diltiazem Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1171 | INJECTION, SOLUTION | 5 mg | INTRAVENOUS | ANDA | 24 sections |