dihydrocodeine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	886	125-28-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: dihydrocodeine codhydrine cohydrin dehacodin dihydroneopine hydrocodeine hydrocodin dihydrocodeine bitartrate parzone bitartrate dihydrocodeine phosphate	Molecular weight: 301.39 Formula: C18H23NO3 CLOGP: 1.26 LIPINSKI: 0 HAC: 4 HDO: 1 TPSA: 41.93 ALOGS: -2.10 ROTB: 1 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

dihydrocodeine
codhydrine
cohydrin
dehacodin
dihydroneopine
hydrocodeine
hydrocodin
dihydrocodeine bitartrate
parzone bitartrate
dihydrocodeine phosphate

Molecular weight: 301.39
Formula: C18H23NO3
CLOGP: 1.26
LIPINSKI: 0
HAC: 4
HDO: 1
TPSA: 41.93
ALOGS: -2.10
ROTB: 1

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.15	g	O

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	20 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	1.07 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	4.21 mL/min/kg	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	3.42 hours	Lombardo F, Berellini G, Obach RS
S (Water solubility)	222 mg/mL	Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
July 7, 1958	FDA	CARACO

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Congenital thrombocytopenia	77.78	26.55	11	3301	55	63485655
Toxicity to various agents	72.30	26.55	76	3236	247174	63238536
Acute kidney injury	71.80	26.55	78	3234	263337	63222373
Neutropenic sepsis	56.90	26.55	24	3288	16414	63469296
Intestinal pseudo-obstruction	48.94	26.55	11	3301	901	63484809
Abdominal pain	47.63	26.55	67	3245	293389	63192321
Perforation	46.10	26.55	11	3301	1172	63484538
Toxic leukoencephalopathy	45.48	26.55	10	3302	741	63484969
Overflow diarrhoea	42.03	26.55	7	3305	115	63485595
Hydronephrosis	41.73	26.55	17	3295	10645	63475065
Limbic encephalitis	41.13	26.55	8	3304	323	63485387
Symptom masked	39.89	26.55	9	3303	750	63484960
Pancreatitis chronic	38.00	26.55	11	3301	2473	63483237
Poisoning deliberate	37.56	26.55	16	3296	11202	63474508
Terminal ileitis	34.66	26.55	8	3304	738	63484972
Acquired cystic kidney disease	31.41	26.55	5	3307	61	63485649
Sepsis	29.39	26.55	38	3274	153085	63332625
Abnormal loss of weight	28.88	26.55	11	3301	5771	63479939
Colitis ischaemic	28.50	26.55	13	3299	10695	63475015
Peritonitis	28.21	26.55	15	3297	17139	63468571
Colitis	28.16	26.55	22	3290	48506	63437204
Brain oedema	27.92	26.55	14	3298	14181	63471529
Biliary sepsis	27.85	26.55	7	3305	924	63484786

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	95.59	23.45	89	2206	200273	34754363
Autoscopy	53.89	23.45	10	2285	247	34954389
Overdose	44.19	23.45	41	2254	91018	34863618
Femoral nerve palsy	37.79	23.45	6	2289	56	34954580
Upper gastrointestinal haemorrhage	26.47	23.45	18	2277	25500	34929136
Electric shock sensation	26.33	23.45	5	2290	140	34954496
Tandem gait test abnormal	25.63	23.45	4	2291	33	34954603
Alcoholic liver disease	24.12	23.45	6	2289	602	34954034
Genital herpes	23.87	23.45	6	2289	629	34954007

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	129.52	21.38	152	5364	421388	79317484
Acute kidney injury	54.12	21.38	114	5402	519290	79219582
Neutropenic sepsis	41.72	21.38	25	5491	27039	79711833
Abnormal loss of weight	41.05	21.38	17	5499	8359	79730513
Perforation	40.97	21.38	11	5505	1415	79737457
Overdose	39.82	21.38	56	5460	184150	79554722
Toxic leukoencephalopathy	38.39	21.38	10	5506	1144	79737728
Overflow diarrhoea	37.66	21.38	7	5509	165	79738707
Abdominal pain	37.61	21.38	83	5433	389486	79349386
Femoral nerve palsy	35.44	21.38	6	5510	81	79738791
Limbic encephalitis	31.14	21.38	8	5508	867	79738005
Upper gastrointestinal haemorrhage	29.94	21.38	24	5492	41356	79697516
Acquired cystic kidney disease	29.43	21.38	5	5511	69	79738803
Drug ineffective	27.37	21.38	21	5495	1080892	78657980
Asphyxia	26.71	21.38	14	5502	11706	79727166
Premature baby	26.71	21.38	10	5506	3770	79735102
Somnolence	26.58	21.38	54	5462	238927	79499945
Hydronephrosis	26.57	21.38	16	5500	17438	79721434
Pancreatitis chronic	26.11	21.38	10	5506	4009	79734863
Terminal ileitis	25.99	21.38	7	5509	910	79737962
Sepsis	24.38	21.38	56	5460	269372	79469500
Faecaloma	24.06	21.38	13	5503	11551	79727321
Alcoholic liver disease	24.05	21.38	6	5510	578	79738294
Poisoning deliberate	22.98	21.38	15	5501	18813	79720059
Tandem gait test abnormal	22.76	21.38	4	5512	68	79738804
Vomiting	22.30	21.38	98	5418	665730	79073142
Respiratory depression	22.09	21.38	17	5499	27613	79711259
Biliary sepsis	22.07	21.38	7	5509	1610	79737262
Electric shock sensation	21.75	21.38	6	5510	853	79738019

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N02AA08	NERVOUS SYSTEM ANALGESICS OPIOIDS Natural opium alkaloids
ATC	N02AA58	NERVOUS SYSTEM ANALGESICS OPIOIDS Natural opium alkaloids
ATC	N02AJ01	NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics
ATC	N02AJ02	NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics
ATC	N02AJ03	NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics
MeSH PA	D000700	Analgesics
MeSH PA	D000701	Analgesics, Opioid
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D009294	Narcotics
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents
FDA MoA	N0000175684	Full Opioid Agonists
FDA EPC	N0000175690	Opioid Agonist

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Pain	indication	22253000
Cough	indication	49727002
Allergic rhinitis	indication	61582004
Nasal discharge	indication	64531003
Nasal congestion	indication	68235000
Rhinitis	indication	70076002	DOID:4483
Common cold	indication	82272006	DOID:10459
Necrotizing enterocolitis in fetus OR newborn	contraindication	2707005
Ocular hypertension	contraindication	4210003	DOID:9282
Suicidal thoughts	contraindication	6471006
Dependent drug abuse	contraindication	6525002
Alcoholism	contraindication	7200002
Alcohol withdrawal delirium	contraindication	8635005
Peptic ulcer	contraindication	13200003	DOID:750
Chronic obstructive lung disease	contraindication	13645005	DOID:3083
Asthenia	contraindication	13791008
Constipation	contraindication	14760008	DOID:2089
Mood swings	contraindication	18963009
Myocardial infarction	contraindication	22298006	DOID:5844
Inflammatory bowel disease	contraindication	24526004	DOID:0050589
Ventricular tachycardia	contraindication	25569003
Alcohol intoxication	contraindication	25702006
Shock	contraindication	27942005
Hypercapnia	contraindication	29596007
Dehydration	contraindication	34095006
Hyperthyroidism	contraindication	34486009	DOID:7998
Acute hepatitis	contraindication	37871000
Hypertensive disorder	contraindication	38341003	DOID:10763
Disorder of gallbladder	contraindication	39621005	DOID:0060262
Gastrointestinal ulcer	contraindication	40845000
Hypothyroidism	contraindication	40930008	DOID:1459
Conduction disorder of the heart	contraindication	44808001
Low blood pressure	contraindication	45007003
Chronic heart failure	contraindication	48447003
Bradycardia	contraindication	48867003
Acidosis	contraindication	51387008
Vitamin K deficiency	contraindication	52675005	DOID:11249
Nasal polyp	contraindication	52756005
Coronary arteriosclerosis	contraindication	53741008	DOID:3393
Acute nephropathy	contraindication	58574008
Hepatic failure	contraindication	59927004
Ulcerative colitis	contraindication	64766004	DOID:8577
Arterial thrombosis	contraindication	65198009
Substance abuse	contraindication	66214007
Benign intracranial hypertension	contraindication	68267002	DOID:11459
Poisoning by acetaminophen	contraindication	70273001
Agoraphobia	contraindication	70691001	DOID:593
Arteriosclerotic vascular disease	contraindication	72092001
Diabetes mellitus	contraindication	73211009	DOID:9351
Factor II deficiency	contraindication	73975000
Reye's syndrome	contraindication	74351001	DOID:14525
Gastrointestinal hemorrhage	contraindication	74474003
Urethral stricture	contraindication	76618002
Thrombotic thrombocytopenic purpura	contraindication	78129009	DOID:10772
Decreased respiratory function	contraindication	80954004
Injury of head	contraindication	82271004
Chronic idiopathic constipation	contraindication	82934008
Cor pulmonale	contraindication	83291003	DOID:8515
Pulmonary emphysema	contraindication	87433001
Gout	contraindication	90560007	DOID:13189
Kidney disease	contraindication	90708001	DOID:557
Hemophilia	contraindication	90935002
Anemia due to enzyme deficiency	contraindication	111577008
Acute abdominal pain	contraindication	116290004
Gastrointestinal obstruction	contraindication	126765001
Neoplasm of brain	contraindication	126952004	DOID:1319
von Willebrand disorder	contraindication	128105004	DOID:12531
Seizure disorder	contraindication	128613002
Drug-induced psychosis	contraindication	191483003	DOID:1742
Obsessive-compulsive disorder	contraindication	191736004	DOID:10933
Insomnia	contraindication	193462001
Partial atrioventricular block	contraindication	195039008
Acute pancreatitis	contraindication	197456007	DOID:2913
Impaired renal function disorder	contraindication	197663003
Disease of liver	contraindication	235856003	DOID:409
Bladder outflow obstruction	contraindication	236645006
Morbid obesity	contraindication	238136002	DOID:11981
Benign prostatic hyperplasia	contraindication	266569009
Retention of urine	contraindication	267064002
Anemia	contraindication	271737000	DOID:2355
Exacerbation of asthma	contraindication	281239006
Pregnancy, function	contraindication	289908002
Lesion of brain	contraindication	301766008
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Panic disorder	contraindication	371631005	DOID:594
Coma	contraindication	371632003
Primary adrenocortical insufficiency	contraindication	373662000
Operation on gastrointestinal tract	contraindication	386621005
Hypoxia	contraindication	389086002
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Breastfeeding (mother)	contraindication	413712001
Disorder of coronary artery	contraindication	414024009
Myocardial ischemia	contraindication	414795007	DOID:3393
Myocardial infarction in recovery phase	contraindication	418044006
Central nervous system depression	contraindication	418072004
Dysfunction of sphincter of Oddi	contraindication	430887001
Hypertensive urgency	contraindication	443482000
Acute erosive gastritis	contraindication	444926003

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.22	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Mu-type opioid receptor	GPCR	P35372	OPRM_HUMAN	AGONIST				CHEMBL	CHEMBL

External reference:

ID	Source
4019720	VUID
N0000147812	NUI
D01481	KEGG_DRUG
5965-13-9	SECONDARY_CAS_RN
104966	RXNORM
4018062	VANDF
4019720	VANDF
C0058056	UMLSCUI
CHEBI:135276	CHEBI
CHEMBL1595	ChEMBL_ID
CHEMBL2062266	ChEMBL_ID
DB01551	DRUGBANK_ID
C014481	MESH_SUPPLEMENTAL_RECORD_UI
5284543	PUBCHEM_CID
7594	IUPHAR_LIGAND_ID
728	INN_ID
24204-13-5	SECONDARY_CAS_RN
N9I9HDB855	UNII
4599	MMSL
d03168	MMSL
001557	NDDF
004420	NDDF
004421	NDDF
322538006	SNOMEDCT_US
387322000	SNOMEDCT_US
57811004	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Acetaminophen, Caffeine, Dihydrocodeine Bitartrate	HUMAN PRESCRIPTION DRUG LABEL	3	42195-840	CAPSULE	16 mg	ORAL	ANDA	28 sections
Dihydrocodeine Bitartrate, Acetaminophen and Caffeine	HUMAN PRESCRIPTION DRUG LABEL	3	54868-5900	TABLET	32 mg	ORAL	ANDA	20 sections
Trezix	HUMAN PRESCRIPTION DRUG LABEL	3	63187-705	CAPSULE	16 mg	ORAL	ANDA	22 sections
Trezix	HUMAN PRESCRIPTION DRUG LABEL	3	63187-705	CAPSULE	16 mg	ORAL	ANDA	22 sections
Trezix	HUMAN PRESCRIPTION DRUG LABEL	3	63629-5637	CAPSULE	16 mg	ORAL	ANDA	22 sections
Trezix	HUMAN PRESCRIPTION DRUG LABEL	3	66992-840	CAPSULE	16 mg	ORAL	ANDA	23 sections
Acetaminophen, Caffeine and Dihydrocodeine Bitartrate	HUMAN PRESCRIPTION DRUG LABEL	3	71993-300	TABLET	16 mg	ORAL	ANDA	27 sections