dihydrocodeine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
886 125-28-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dihydrocodeine
  • codhydrine
  • cohydrin
  • dehacodin
  • dihydroneopine
  • hydrocodeine
  • hydrocodin
  • dihydrocodeine bitartrate
  • parzone bitartrate
  • dihydrocodeine phosphate
  • Molecular weight: 301.39
  • Formula: C18H23NO3
  • CLOGP: 1.26
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 41.93
  • ALOGS: -2.10
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 20 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.07 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.21 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.42 hours Lombardo F, Berellini G, Obach RS
S (Water solubility) 222 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
July 7, 1958 FDA CARACO

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Congenital thrombocytopenia 77.78 26.55 11 3301 55 63485655
Toxicity to various agents 72.30 26.55 76 3236 247174 63238536
Acute kidney injury 71.80 26.55 78 3234 263337 63222373
Neutropenic sepsis 56.90 26.55 24 3288 16414 63469296
Intestinal pseudo-obstruction 48.94 26.55 11 3301 901 63484809
Abdominal pain 47.63 26.55 67 3245 293389 63192321
Perforation 46.10 26.55 11 3301 1172 63484538
Toxic leukoencephalopathy 45.48 26.55 10 3302 741 63484969
Overflow diarrhoea 42.03 26.55 7 3305 115 63485595
Hydronephrosis 41.73 26.55 17 3295 10645 63475065
Limbic encephalitis 41.13 26.55 8 3304 323 63485387
Symptom masked 39.89 26.55 9 3303 750 63484960
Pancreatitis chronic 38.00 26.55 11 3301 2473 63483237
Poisoning deliberate 37.56 26.55 16 3296 11202 63474508
Terminal ileitis 34.66 26.55 8 3304 738 63484972
Acquired cystic kidney disease 31.41 26.55 5 3307 61 63485649
Sepsis 29.39 26.55 38 3274 153085 63332625
Abnormal loss of weight 28.88 26.55 11 3301 5771 63479939
Colitis ischaemic 28.50 26.55 13 3299 10695 63475015
Peritonitis 28.21 26.55 15 3297 17139 63468571
Colitis 28.16 26.55 22 3290 48506 63437204
Brain oedema 27.92 26.55 14 3298 14181 63471529
Biliary sepsis 27.85 26.55 7 3305 924 63484786

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 95.59 23.45 89 2206 200273 34754363
Autoscopy 53.89 23.45 10 2285 247 34954389
Overdose 44.19 23.45 41 2254 91018 34863618
Femoral nerve palsy 37.79 23.45 6 2289 56 34954580
Upper gastrointestinal haemorrhage 26.47 23.45 18 2277 25500 34929136
Electric shock sensation 26.33 23.45 5 2290 140 34954496
Tandem gait test abnormal 25.63 23.45 4 2291 33 34954603
Alcoholic liver disease 24.12 23.45 6 2289 602 34954034
Genital herpes 23.87 23.45 6 2289 629 34954007

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 129.52 21.38 152 5364 421388 79317484
Acute kidney injury 54.12 21.38 114 5402 519290 79219582
Neutropenic sepsis 41.72 21.38 25 5491 27039 79711833
Abnormal loss of weight 41.05 21.38 17 5499 8359 79730513
Perforation 40.97 21.38 11 5505 1415 79737457
Overdose 39.82 21.38 56 5460 184150 79554722
Toxic leukoencephalopathy 38.39 21.38 10 5506 1144 79737728
Overflow diarrhoea 37.66 21.38 7 5509 165 79738707
Abdominal pain 37.61 21.38 83 5433 389486 79349386
Femoral nerve palsy 35.44 21.38 6 5510 81 79738791
Limbic encephalitis 31.14 21.38 8 5508 867 79738005
Upper gastrointestinal haemorrhage 29.94 21.38 24 5492 41356 79697516
Acquired cystic kidney disease 29.43 21.38 5 5511 69 79738803
Drug ineffective 27.37 21.38 21 5495 1080892 78657980
Asphyxia 26.71 21.38 14 5502 11706 79727166
Premature baby 26.71 21.38 10 5506 3770 79735102
Somnolence 26.58 21.38 54 5462 238927 79499945
Hydronephrosis 26.57 21.38 16 5500 17438 79721434
Pancreatitis chronic 26.11 21.38 10 5506 4009 79734863
Terminal ileitis 25.99 21.38 7 5509 910 79737962
Sepsis 24.38 21.38 56 5460 269372 79469500
Faecaloma 24.06 21.38 13 5503 11551 79727321
Alcoholic liver disease 24.05 21.38 6 5510 578 79738294
Poisoning deliberate 22.98 21.38 15 5501 18813 79720059
Tandem gait test abnormal 22.76 21.38 4 5512 68 79738804
Vomiting 22.30 21.38 98 5418 665730 79073142
Respiratory depression 22.09 21.38 17 5499 27613 79711259
Biliary sepsis 22.07 21.38 7 5509 1610 79737262
Electric shock sensation 21.75 21.38 6 5510 853 79738019

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N02AA08 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Natural opium alkaloids
ATC N02AA58 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Natural opium alkaloids
ATC N02AJ01 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ02 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ03 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
MeSH PA D000700 Analgesics
MeSH PA D000701 Analgesics, Opioid
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D009294 Narcotics
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
FDA MoA N0000175684 Full Opioid Agonists
FDA EPC N0000175690 Opioid Agonist

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000
Cough indication 49727002
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Rhinitis indication 70076002 DOID:4483
Common cold indication 82272006 DOID:10459
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Ocular hypertension contraindication 4210003 DOID:9282
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Constipation contraindication 14760008 DOID:2089
Mood swings contraindication 18963009
Myocardial infarction contraindication 22298006 DOID:5844
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Hypercapnia contraindication 29596007
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Acidosis contraindication 51387008
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Ulcerative colitis contraindication 64766004 DOID:8577
Arterial thrombosis contraindication 65198009
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Poisoning by acetaminophen contraindication 70273001
Agoraphobia contraindication 70691001 DOID:593
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Cor pulmonale contraindication 83291003 DOID:8515
Pulmonary emphysema contraindication 87433001
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Anemia due to enzyme deficiency contraindication 111577008
Acute abdominal pain contraindication 116290004
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
von Willebrand disorder contraindication 128105004 DOID:12531
Seizure disorder contraindication 128613002
Drug-induced psychosis contraindication 191483003 DOID:1742
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Exacerbation of asthma contraindication 281239006
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Panic disorder contraindication 371631005 DOID:594
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Central nervous system depression contraindication 418072004
Dysfunction of sphincter of Oddi contraindication 430887001
Hypertensive urgency contraindication 443482000
Acute erosive gastritis contraindication 444926003




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.22 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Mu-type opioid receptor GPCR AGONIST CHEMBL CHEMBL

External reference:

IDSource
4019720 VUID
N0000147812 NUI
D01481 KEGG_DRUG
5965-13-9 SECONDARY_CAS_RN
104966 RXNORM
4018062 VANDF
4019720 VANDF
C0058056 UMLSCUI
CHEBI:135276 CHEBI
CHEMBL1595 ChEMBL_ID
CHEMBL2062266 ChEMBL_ID
DB01551 DRUGBANK_ID
C014481 MESH_SUPPLEMENTAL_RECORD_UI
5284543 PUBCHEM_CID
7594 IUPHAR_LIGAND_ID
728 INN_ID
24204-13-5 SECONDARY_CAS_RN
N9I9HDB855 UNII
4599 MMSL
d03168 MMSL
001557 NDDF
004420 NDDF
004421 NDDF
322538006 SNOMEDCT_US
387322000 SNOMEDCT_US
57811004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Acetaminophen, Caffeine, Dihydrocodeine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 3 42195-840 CAPSULE 16 mg ORAL ANDA 28 sections
Dihydrocodeine Bitartrate, Acetaminophen and Caffeine HUMAN PRESCRIPTION DRUG LABEL 3 54868-5900 TABLET 32 mg ORAL ANDA 20 sections
Trezix HUMAN PRESCRIPTION DRUG LABEL 3 63187-705 CAPSULE 16 mg ORAL ANDA 22 sections
Trezix HUMAN PRESCRIPTION DRUG LABEL 3 63187-705 CAPSULE 16 mg ORAL ANDA 22 sections
Trezix HUMAN PRESCRIPTION DRUG LABEL 3 63629-5637 CAPSULE 16 mg ORAL ANDA 22 sections
Trezix HUMAN PRESCRIPTION DRUG LABEL 3 66992-840 CAPSULE 16 mg ORAL ANDA 23 sections
Acetaminophen, Caffeine and Dihydrocodeine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 3 71993-300 TABLET 16 mg ORAL ANDA 27 sections