diethylpropion 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anorexics	874	90-84-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: diethylpropion adiposon amfepramon amfepramone amphepramon amphepramone diethpropion diethylpropione nopropiophenone diethylpropion hydrochloride amfepramone hydrochloride diethylpropion HCl amfepramone HCl	A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290) Molecular weight: 205.30 Formula: C13H19NO CLOGP: 2.85 LIPINSKI: 0 HAC: 2 HDO: 0 TPSA: 20.31 ALOGS: -2.23 ROTB: 5 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

diethylpropion
adiposon
amfepramon
amfepramone
amphepramon
amphepramone
diethpropion
diethylpropione
nopropiophenone
diethylpropion hydrochloride
amfepramone hydrochloride
diethylpropion HCl
amfepramone HCl

A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)

Molecular weight: 205.30
Formula: C13H19NO
CLOGP: 2.85
LIPINSKI: 0
HAC: 2
HDO: 0
TPSA: 20.31
ALOGS: -2.23
ROTB: 5

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
75	mg	O

ADMET properties:

Property	Value	Reference
S (Water solubility)	1.22 mg/mL	Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
Aug. 6, 1959	FDA	ACTAVIS LABS UT INC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A08AA03	ALIMENTARY TRACT AND METABOLISM ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS Centrally acting antiobesity products
FDA PE	N0000175372	Appetite Suppression
FDA EPC	N0000175423	Sympathomimetic Amine Anorectic
MeSH PA	D019440	Anti-Obesity Agents
MeSH PA	D001067	Appetite Depressants
FDA PE	N0000175651	Increased Sympathetic Activity
CHEBI has role	CHEBI:50507	appetite depressant

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Obesity	indication	414916001	DOID:9970
Heart valve disorder	contraindication	368009	DOID:4079
Alcoholism	contraindication	7200002
Glaucoma	contraindication	23986001	DOID:1686
Feeling agitated	contraindication	24199005
Hyperthyroidism	contraindication	34486009	DOID:7998
Hypertensive disorder	contraindication	38341003	DOID:10763
Diabetes mellitus type 2	contraindication	44054006	DOID:9352
Conduction disorder of the heart	contraindication	44808001
Diabetes mellitus type 1	contraindication	46635009	DOID:9744
Chronic heart failure	contraindication	48447003
Substance abuse	contraindication	66214007
Pulmonary hypertension	contraindication	70995007	DOID:6432
Arteriosclerotic vascular disease	contraindication	72092001
Epilepsy	contraindication	84757009	DOID:1826
Drug-induced psychosis	contraindication	191483003	DOID:1742
Breastfeeding (mother)	contraindication	413712001
Disorder of coronary artery	contraindication	414024009
Hypertensive urgency	contraindication	443482000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.17	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN	INHIBITOR				CHEMBL	CHEMBL
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN	INHIBITOR				CHEMBL	CHEMBL

External reference:

ID	Source
4019717	VUID
N0000147809	NUI
D03801	KEGG_DRUG
134-80-5	SECONDARY_CAS_RN
3389	RXNORM
4018577	VANDF
4019717	VANDF
C0012201	UMLSCUI
CHEBI:4530	CHEBI
CHEMBL1194666	ChEMBL_ID
DB00937	DRUGBANK_ID
CHEMBL1693	ChEMBL_ID
D004053	MESH_DESCRIPTOR_UI
7029	PUBCHEM_CID
7161	IUPHAR_LIGAND_ID
974	INN_ID
Q94YYU22B8	UNII
1175	MMSL
4590	MMSL
d00810	MMSL
001867	NDDF
004773	NDDF
37765000	SNOMEDCT_US
387303009	SNOMEDCT_US
54882005	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Diethylpropion Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0527-1475	TABLET	25 mg	ORAL	ANDA	22 sections
Diethylpropion Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0527-1475	TABLET	25 mg	ORAL	ANDA	22 sections
Diethylpropion HydrochlorideER	HUMAN PRESCRIPTION DRUG LABEL	1	0527-1477	TABLET, EXTENDED RELEASE	75 mg	ORAL	ANDA	21 sections
Diethylpropion HydrochlorideER	HUMAN PRESCRIPTION DRUG LABEL	1	0527-1477	TABLET, EXTENDED RELEASE	75 mg	ORAL	ANDA	21 sections
Diethylpropion HCl Controlled-Release	HUMAN PRESCRIPTION DRUG LABEL	1	10544-598	TABLET	75 mg	ORAL	ANDA	22 sections
DIETHYLPROPION HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	10702-044	TABLET	25 mg	ORAL	ANDA	21 sections
Diethylpropion Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	12634-530	TABLET	25 mg	ORAL	NDA	23 sections
diethylpropion hydrochloride er	HUMAN PRESCRIPTION DRUG LABEL	1	12634-691	TABLET	75 mg	ORAL	NDA	23 sections
Diethylpropion HydrochlorideER	HUMAN PRESCRIPTION DRUG LABEL	1	17224-360	TABLET, EXTENDED RELEASE	75 mg	ORAL	ANDA	21 sections
DIETHYLPROPION HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	17224-730	TABLET	25 mg	ORAL	ANDA	21 sections
Diethylpropion HydrochlorideER	HUMAN PRESCRIPTION DRUG LABEL	1	17224-760	TABLET, EXTENDED RELEASE	75 mg	ORAL	ANDA	21 sections
Diethylpropion HCl Controlled-Release	HUMAN PRESCRIPTION DRUG LABEL	1	21695-876	TABLET	75 mg	ORAL	NDA	22 sections
DIETHYLPROPION HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	33261-353	TABLET	25 mg	ORAL	ANDA	21 sections
Diethylpropion HydrochlorideERER	HUMAN PRESCRIPTION DRUG LABEL	1	33261-354	TABLET, EXTENDED RELEASE	75 mg	ORAL	ANDA	23 sections
DIETHYLPROPION HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	43063-348	TABLET	25 mg	ORAL	ANDA	21 sections
DIETHYLPROPION HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	43063-348	TABLET	25 mg	ORAL	ANDA	21 sections
DIETHYLPROPION HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	43063-348	TABLET	25 mg	ORAL	ANDA	21 sections
Diethylpropion HydrochlorideER	HUMAN PRESCRIPTION DRUG LABEL	1	43063-532	TABLET, EXTENDED RELEASE	75 mg	ORAL	ANDA	21 sections
Diethylpropion HydrochlorideER	HUMAN PRESCRIPTION DRUG LABEL	1	43063-532	TABLET, EXTENDED RELEASE	75 mg	ORAL	ANDA	21 sections
Diethylpropion HydrochlorideER	HUMAN PRESCRIPTION DRUG LABEL	1	43063-532	TABLET, EXTENDED RELEASE	75 mg	ORAL	ANDA	21 sections
Diethylpropion HydrochlorideER	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0120	TABLET, EXTENDED RELEASE	75 mg	ORAL	ANDA	22 sections
Diethylpropion HydrochlorideER	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0120	TABLET, EXTENDED RELEASE	75 mg	ORAL	ANDA	22 sections
Diethylpropion HCl Controlled-Release	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0121	TABLET	75 mg	ORAL	NDA	23 sections
Diethylpropion HCl Immediate-Release	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0326	TABLET	25 mg	ORAL	NDA	23 sections
DIETHYLPROPION HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0327	TABLET	25 mg	ORAL	ANDA	21 sections
DIETHYLPROPION HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0327	TABLET	25 mg	ORAL	ANDA	21 sections
DIETHYLPROPION HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	50436-4164	TABLET	25 mg	ORAL	ANDA	20 sections
DIETHYLPROPION HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	52959-150	TABLET	25 mg	ORAL	ANDA	11 sections
Diethylpropion Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	52959-329	TABLET, EXTENDED RELEASE	75 mg	ORAL	ANDA	11 sections
Diethylpropion Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	53217-230	TABLET	25 mg	ORAL	ANDA	24 sections