diethylcarbamazine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
873 90-89-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • diethylcarbamazine citrate
  • diethylcarbamazine
  • carbamazine
  • carbilazine
  • bitirazine
  • caricide
  • ethodryl
  • notezine
An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.
  • Molecular weight: 199.30
  • Formula: C10H21N3O
  • CLOGP: 1.62
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 26.79
  • ALOGS: 0.07
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 0 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 63.70 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 35 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 30.11 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Nov. 13, 1950 FDA LEDERLE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC P02CB02 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTHELMINTICS
ANTINEMATODAL AGENTS
Piperazine and derivatives
FDA EPC N0000175481 Anthelmintic
MeSH PA D000871 Anthelmintics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000969 Antinematodal Agents
MeSH PA D000977 Antiparasitic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005369 Filaricides
MeSH PA D016859 Lipoxygenase Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Infection by Onchocerca volvulus indication 38539003 DOID:11678
Infection by Loa loa indication 44250009 DOID:13523
Lymphatic filariasis indication 240820001 DOID:12211
Eosinophilic asthma indication 367542003 DOID:9498
Bancroft's Filariasis indication




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Cats Removal of ascarids, Toxocara canis Indication
Cats Removal of ascarids, Toxascaris leonina Indication
Dogs Infection with Dirofilaria immitis (heartworm disease) Indication
Dogs Removal of ascarids, Toxocara canis Indication
Dogs Removal of ascarids, Toxascaris leonina Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Diethylcarbamazine Citrate Tab., Diro-Form Lloyd Inc. 1
Nemacide Oral Syrup Cronus Pharma Specialities India Private Limited 1
Dirocide Tablets Zoetis Inc. 1
Filaribits Chewable Tablets Zoetis Inc. 1
Carbam Tablets Bimeda Animal Health Limited 1
Carbam Palatabs Bimeda Animal Health Limited 1
Filban Chewable Wafers Intervet Inc. 1
Filban Tablets Intervet Inc. 1
Nemacide, Nemacide-C Cronus Pharma Specialities India Private Limited 1
Nemacide Chewable Tablets Cronus Pharma Specialities India Private Limited 1
Pet-Dec Zoetis Inc. 1
Dirocide Syrup Zoetis Inc. 1
Filaribits Plus Chewable Tablets Zoetis Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.53 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 1 Enzyme WOMBAT-PK
Arachidonate 5-lipoxygenase Enzyme WOMBAT-PK
Nematode GABA-A receptor Ion channel POSITIVE MODULATOR CHEMBL CHEMBL

External reference:

IDSource
D00803 KEGG_DRUG
1642-54-2 SECONDARY_CAS_RN
203175 RXNORM
C0012191 UMLSCUI
CHEBI:4527 CHEBI
CHEMBL684 ChEMBL_ID
CHEMBL48977 ChEMBL_ID
DB00711 DRUGBANK_ID
CHEMBL937 ChEMBL_ID
D004049 MESH_DESCRIPTOR_UI
3052 PUBCHEM_CID
1540 INN_ID
V867Q8X3ZD UNII
002970 NDDF
004969 NDDF
387340001 SNOMEDCT_US
60731009 SNOMEDCT_US

Pharmaceutical products:

None