Stem definition | Drug id | CAS RN |
---|---|---|
873 | 90-89-1 |
Dose | Unit | Route |
---|---|---|
0.40 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 0 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 63.70 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 35 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 30.11 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 13, 1950 | FDA | LEDERLE |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | P02CB02 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTHELMINTICS ANTINEMATODAL AGENTS Piperazine and derivatives |
FDA EPC | N0000175481 | Anthelmintic |
MeSH PA | D000871 | Anthelmintics |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000969 | Antinematodal Agents |
MeSH PA | D000977 | Antiparasitic Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D005369 | Filaricides |
MeSH PA | D016859 | Lipoxygenase Inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Infection by Onchocerca volvulus | indication | 38539003 | DOID:11678 |
Infection by Loa loa | indication | 44250009 | DOID:13523 |
Lymphatic filariasis | indication | 240820001 | DOID:12211 |
Eosinophilic asthma | indication | 367542003 | DOID:9498 |
Bancroft's Filariasis | indication |
Species | Use | Relation |
---|---|---|
Cats | Removal of ascarids, Toxocara canis | Indication |
Cats | Removal of ascarids, Toxascaris leonina | Indication |
Dogs | Infection with Dirofilaria immitis (heartworm disease) | Indication |
Dogs | Removal of ascarids, Toxocara canis | Indication |
Dogs | Removal of ascarids, Toxascaris leonina | Indication |
Product | Applicant | Ingredients |
---|---|---|
Diethylcarbamazine Citrate Tab., Diro-Form | Lloyd Inc. | 1 |
Nemacide Oral Syrup | Cronus Pharma Specialities India Private Limited | 1 |
Dirocide Tablets | Zoetis Inc. | 1 |
Filaribits Chewable Tablets | Zoetis Inc. | 1 |
Carbam Tablets | Bimeda Animal Health Limited | 1 |
Carbam Palatabs | Bimeda Animal Health Limited | 1 |
Filban Chewable Wafers | Intervet Inc. | 1 |
Filban Tablets | Intervet Inc. | 1 |
Nemacide, Nemacide-C | Cronus Pharma Specialities India Private Limited | 1 |
Nemacide Chewable Tablets | Cronus Pharma Specialities India Private Limited | 1 |
Pet-Dec | Zoetis Inc. | 1 |
Dirocide Syrup | Zoetis Inc. | 1 |
Filaribits Plus Chewable Tablets | Zoetis Inc. | 2 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.53 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 1 | Enzyme | WOMBAT-PK | |||||||
Arachidonate 5-lipoxygenase | Enzyme | WOMBAT-PK | |||||||
Nematode GABA-A receptor | Ion channel | POSITIVE MODULATOR | CHEMBL | CHEMBL |
ID | Source |
---|---|
D00803 | KEGG_DRUG |
1642-54-2 | SECONDARY_CAS_RN |
203175 | RXNORM |
C0012191 | UMLSCUI |
CHEBI:4527 | CHEBI |
CHEMBL684 | ChEMBL_ID |
CHEMBL48977 | ChEMBL_ID |
DB00711 | DRUGBANK_ID |
CHEMBL937 | ChEMBL_ID |
D004049 | MESH_DESCRIPTOR_UI |
3052 | PUBCHEM_CID |
1540 | INN_ID |
V867Q8X3ZD | UNII |
002970 | NDDF |
004969 | NDDF |
1197375009 | SNOMEDCT_US |
387340001 | SNOMEDCT_US |
60731009 | SNOMEDCT_US |
None