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diethylcarbamazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 873 | 90-89-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.40 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 0 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 63.70 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 35 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 30.11 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 93 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AXL,BRAF,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAP3K21,MAP3K7,MAPK7,MAPKAPK2,NTRK2,PDK4,PRKDC,SIK2,TEK | 25 | |||
| kinase-selectivity-class | AXL,BRAF,CAMK2D,CDK16,CDK4,CDK6,CDK7,CSF1R,DDR1,EPHB4,FLT3,IRAK1,MAP3K7,MAP3K9,MAPK7,PRKCD,SIK2,SIK3,STK33,ULK1 | 20 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 13, 1950 | FDA | LEDERLE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Product use in unapproved indication | 67.24 | 66.75 | 20 | 54 | 447357 | 110141868 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | P02CB02 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTHELMINTICS ANTINEMATODAL AGENTS Piperazine and derivatives |
| FDA EPC | N0000175481 | Anthelmintic |
| MeSH PA | D000871 | Anthelmintics |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000969 | Antinematodal Agents |
| MeSH PA | D000977 | Antiparasitic Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D005369 | Filaricides |
| MeSH PA | D016859 | Lipoxygenase Inhibitors |
| CHEBI has role | CHEBI:35441 | antiinfective agent |
| CHEBI has role | CHEBI:35442 | antiparasitic agent |
| CHEBI has role | CHEBI:35443 | anthelminthic drug |
Related Drugs by ATC class:
P02CB Piperazine and derivatives 1 drug
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Infection by Onchocerca volvulus | indication | 38539003 | DOID:11678 |
| Infection by Loa loa | indication | 44250009 | DOID:13523 |
| Lymphatic filariasis | indication | 240820001 | DOID:12211 |
| Eosinophilic asthma | indication | 367542003 | DOID:9498 |
| Bancroft's Filariasis | indication |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cats | Removal of ascarids, Toxocara canis | Indication |
| Cats | Removal of ascarids, Toxascaris leonina | Indication |
| Dogs | Infection with Dirofilaria immitis (heartworm disease) | Indication |
| Dogs | Removal of ascarids, Toxocara canis | Indication |
| Dogs | Removal of ascarids, Toxascaris leonina | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Diethylcarbamazine Citrate Tab., Diro-Form | Lloyd Inc. | 1 |
| Nemacide Oral Syrup | Cronus Pharma Specialities India Private Limited | 1 |
| Dirocide Tablets | Zoetis Inc. | 1 |
| Filaribits Chewable Tablets | Zoetis Inc. | 1 |
| Carbam Tablets | Bimeda Animal Health Limited | 1 |
| Carbam Palatabs | Bimeda Animal Health Limited | 1 |
| Filban Chewable Wafers | Intervet Inc. | 1 |
| Filban Tablets | Intervet Inc. | 1 |
| Nemacide, Nemacide-C | Cronus Pharma Specialities India Private Limited | 1 |
| Nemacide Chewable Tablets | Cronus Pharma Specialities India Private Limited | 1 |
| Pet-Dec | Zoetis Inc. | 1 |
| Dirocide Syrup | Zoetis Inc. | 1 |
| Filaribits Plus Chewable Tablets | Zoetis Inc. | 2 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.53 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 1 | Enzyme | WOMBAT-PK | |||||||
| Arachidonate 5-lipoxygenase | Enzyme | WOMBAT-PK | |||||||
| Nematode GABA-A receptor | Ion channel | POSITIVE MODULATOR | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D00803 | KEGG_DRUG |
| 1642-54-2 | SECONDARY_CAS_RN |
| 203175 | RXNORM |
| C0012191 | UMLSCUI |
| CHEBI:4527 | CHEBI |
| CHEMBL684 | ChEMBL_ID |
| DB00711 | DRUGBANK_ID |
| CHEMBL937 | ChEMBL_ID |
| D004049 | MESH_DESCRIPTOR_UI |
| 3052 | PUBCHEM_CID |
| 1540 | INN_ID |
| V867Q8X3ZD | UNII |
| 002970 | NDDF |
| 004969 | NDDF |
| 1197375009 | SNOMEDCT_US |
| 387340001 | SNOMEDCT_US |
| 60731009 | SNOMEDCT_US |
Pharmaceutical products:
None