acyclovir 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antivirals bicyclic heterocycle compounds 85 59277-89-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • zovirax
  • acyclovir
  • aciclovir
  • acyclovir sodium
Acyclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. In vitro, acyclovir triphosphate stops replication of herpes viral DNA.
  • Molecular weight: 225.21
  • Formula: C8H11N5O3
  • CLOGP: -2.02
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 3
  • TPSA: 114.76
  • ALOGS: -1.42
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
4 g O
4 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1.62 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 75 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 59.06 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 22.50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.71 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.85 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.50 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
March 29, 1982 FDA VALEANT BERMUDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 1527.60 10.15 996 151864 34909 63301253
White blood cell count decreased 825.74 10.15 1318 151542 137786 63198376
Febrile neutropenia 793.57 10.15 1187 151673 117262 63218900
Platelet count decreased 590.65 10.15 1027 151833 115095 63221067
Neuropathy peripheral 555.70 10.15 988 151872 112679 63223483
Lymphocyte count decreased 509.75 10.15 486 152374 29771 63306391
Neutropenia 469.84 10.15 1191 151669 173814 63162348
Contraindicated product administered 463.82 10.15 13 152847 217635 63118527
Neutrophil count decreased 448.94 10.15 614 152246 55792 63280370
Rheumatoid arthritis 447.17 10.15 46 152814 253773 63082389
Pemphigus 415.56 10.15 5 152855 183721 63152441
Drug ineffective 412.39 10.15 1228 151632 1043537 62292625
Synovitis 410.44 10.15 8 152852 186910 63149252
Full blood count decreased 402.69 10.15 399 152461 25625 63310537
Urine abnormality 400.65 10.15 235 152625 6784 63329378
Systemic lupus erythematosus 389.16 10.15 30 152830 208888 63127274
Thrombocytopenia 374.02 10.15 998 151862 150159 63186003
Hand deformity 366.84 10.15 3 152857 159454 63176708
Pneumonia 338.88 10.15 2065 150795 454702 62881460
Diarrhoea 334.74 10.15 2894 149966 712472 62623690
Cytokine release syndrome 310.19 10.15 265 152595 14049 63322113
Glossodynia 300.92 10.15 38 152822 178838 63157324
Therapeutic product effect decreased 286.92 10.15 58 152802 193129 63143033
Treatment failure 280.96 10.15 67 152793 198976 63137186
Laboratory test abnormal 280.41 10.15 335 152525 26577 63309585
Wound 257.56 10.15 42 152818 163221 63172941
Pyrexia 254.12 10.15 1968 150892 468510 62867652
Urinary sediment present 253.41 10.15 118 152742 2085 63334077
Drug intolerance 251.40 10.15 224 152636 308437 63027725
Urine leukocyte esterase positive 250.65 10.15 137 152723 3442 63332720
Pain 248.87 10.15 932 151928 739696 62596466
Arthralgia 247.86 10.15 637 152223 569073 62767089
Cytomegalovirus infection 247.09 10.15 278 152582 20674 63315488
Constipation 234.27 10.15 1117 151743 223826 63112336
Neurotoxicity 232.80 10.15 244 152616 16746 63319416
Joint swelling 231.37 10.15 269 152591 327397 63008765
Completed suicide 230.84 10.15 37 152823 145636 63190526
Arthropathy 230.49 10.15 140 152720 234652 63101510
Maternal exposure during pregnancy 226.29 10.15 124 152736 219938 63116224
Discomfort 221.60 10.15 64 152796 167310 63168852
Pericarditis 221.14 10.15 28 152832 131551 63204611
Sepsis 217.85 10.15 836 152024 152287 63183875
Swelling 216.90 10.15 206 152654 275172 63060990
Red blood cells urine positive 214.34 10.15 118 152742 3008 63333154
White blood cells urine positive 214.04 10.15 141 152719 5017 63331145
Crystal urine present 207.18 10.15 94 152766 1560 63334602
Alopecia 198.05 10.15 317 152543 337219 62998943
Condition aggravated 190.25 10.15 430 152430 401787 62934375
Thrombosis 189.59 10.15 456 152404 64299 63271863
Graft versus host disease 186.21 10.15 144 152716 6619 63329543
Helicobacter infection 185.64 10.15 9 152851 92776 63243386
Sensitisation 181.83 10.15 109 152751 3277 63332885
Infusion related reaction 178.17 10.15 197 152663 245324 63090838
Lymphocyte percentage decreased 173.15 10.15 101 152759 2884 63333278
Neutrophil percentage increased 171.82 10.15 100 152760 2843 63333319
Pancytopenia 170.95 10.15 568 152292 96365 63239797
Drug hypersensitivity 170.05 10.15 305 152555 310382 63025780
Blood urine present 169.30 10.15 195 152665 14874 63321288
Urine analysis abnormal 165.37 10.15 119 152741 4897 63331265
Hypersensitivity 154.23 10.15 294 152566 292391 63043771
Polycystic ovaries 154.14 10.15 109 152751 4362 63331800
Abdominal discomfort 154.13 10.15 340 152520 320545 63015617
Psoriatic arthropathy 152.49 10.15 20 152840 91500 63244662
Product use issue 148.14 10.15 188 152672 220332 63115830
Hepatic enzyme increased 146.03 10.15 163 152697 202165 63133997
Ejection fraction 141.12 10.15 82 152778 2324 63333838
Muscle injury 135.16 10.15 5 152855 65340 63270822
Toxicity to various agents 134.08 10.15 244 152616 247006 63089156
Acute kidney injury 133.55 10.15 1087 151773 262328 63073834
Injection site pain 129.24 10.15 76 152784 129724 63206438
Plasma cell myeloma recurrent 124.09 10.15 84 152776 3129 63333033
Intentional overdose 124.02 10.15 16 152844 74136 63262026
Bacterial test positive 122.69 10.15 102 152758 5205 63330957
Multiple organ dysfunction syndrome 122.66 10.15 357 152503 56395 63279767
Epstein-Barr virus infection 118.19 10.15 120 152740 7930 63328232
Bacterial test 117.06 10.15 57 152803 1117 63335045
Renal disorder 116.26 10.15 250 152610 32724 63303438
Urine ketone body present 115.13 10.15 73 152787 2430 63333732
Blood test abnormal 113.63 10.15 163 152697 15466 63320696
Folliculitis 113.30 10.15 17 152843 70300 63265862
Musculoskeletal stiffness 112.32 10.15 169 152691 184449 63151713
Encephalitis viral 109.53 10.15 62 152798 1670 63334492
Pathogen resistance 108.14 10.15 103 152757 6295 63329867
Impaired healing 107.93 10.15 56 152804 102486 63233676
Culture urine positive 106.98 10.15 81 152779 3606 63332556
Acute myeloid leukaemia 106.33 10.15 166 152694 16981 63319181
Acute graft versus host disease 106.32 10.15 87 152773 4341 63331821
Meningoencephalitis herpetic 106.00 10.15 54 152806 1170 63334992
Drug abuse 105.05 10.15 23 152837 72495 63263667
Neutropenic sepsis 104.53 10.15 161 152699 16277 63319885
Mucosal inflammation 104.11 10.15 298 152562 46630 63289532
Type 2 diabetes mellitus 103.92 10.15 15 152845 63853 63272309
Cytomegalovirus viraemia 103.28 10.15 95 152765 5554 63330608
Knee arthroplasty 103.08 10.15 7 152853 54199 63281963
Irritable bowel syndrome 101.06 10.15 36 152824 82376 63253786
Muscle spasms 100.43 10.15 682 152178 155468 63180694
Mobility decreased 97.19 10.15 89 152771 121070 63215092
Cytopenia 94.82 10.15 128 152732 11473 63324689
Encephalopathy 94.32 10.15 254 152606 38366 63297796
Post transplant lymphoproliferative disorder 92.74 10.15 85 152775 4946 63331216
Haemoglobin urine present 91.31 10.15 43 152817 780 63335382
Bronchopulmonary aspergillosis 89.12 10.15 107 152753 8528 63327634
Smooth muscle cell neoplasm 87.38 10.15 42 152818 799 63335363
Blood potassium decreased 86.64 10.15 260 152600 41766 63294396
Hip arthroplasty 85.45 10.15 8 152852 47638 63288524
Pre-engraftment immune reaction 85.38 10.15 29 152831 209 63335953
Red blood cell count decreased 83.36 10.15 251 152609 40394 63295768
Crystalluria 82.80 10.15 33 152827 390 63335772
Ill-defined disorder 82.60 10.15 47 152813 81708 63254454
Specific gravity urine decreased 81.09 10.15 39 152821 743 63335419
Rhinitis allergic 80.45 10.15 119 152741 11608 63324554
Lymphopenia 80.16 10.15 152 152708 18175 63317987
Acute graft versus host disease in skin 79.08 10.15 66 152794 3386 63332776
Herpes simplex 78.10 10.15 98 152762 8173 63327989
Inappropriate schedule of product administration 76.89 10.15 82 152778 103883 63232279
Immune effector cell-associated neurotoxicity syndrome 75.01 10.15 54 152806 2223 63333939
Nephropathy toxic 73.56 10.15 102 152758 9377 63326785
Ageusia 73.03 10.15 124 152736 13604 63322558
C-reactive protein abnormal 72.32 10.15 12 152848 46084 63290078
Light chain analysis increased 71.80 10.15 43 152817 1290 63334872
Stem cell transplant 71.24 10.15 48 152812 1774 63334388
Blood creatinine increased 70.39 10.15 406 152454 87438 63248724
Ejection fraction abnormal 69.73 10.15 47 152813 1738 63334424
Nitrite urine present 69.69 10.15 39 152821 1027 63335135
Red cell distribution width increased 69.63 10.15 105 152755 10419 63325743
Psoriasis 69.58 10.15 64 152796 86893 63249269
Nephrectomy 69.41 10.15 44 152816 1464 63334698
Herpes zoster 69.29 10.15 386 152474 82076 63254086
Human herpesvirus 6 infection 68.70 10.15 57 152803 2900 63333262
Haemoglobin decreased 68.61 10.15 591 152269 144894 63191268
Overdose 68.36 10.15 107 152753 114971 63221191
Cytomegalovirus test positive 67.68 10.15 57 152803 2961 63333201
Encephalitis cytomegalovirus 67.49 10.15 31 152829 530 63335632
Encephalitis 66.60 10.15 94 152766 8786 63327376
Suicide attempt 66.00 10.15 32 152828 60886 63275276
Acute graft versus host disease in intestine 65.82 10.15 45 152815 1704 63334458
Red blood cell sedimentation rate increased 65.66 10.15 13 152847 43969 63292193
Sleep disorder due to general medical condition, insomnia type 65.41 10.15 22 152838 52195 63283967
Unevaluable event 64.50 10.15 270 152590 51116 63285046
Monocyte percentage increased 64.36 10.15 38 152822 1110 63335052
Cytomegalovirus infection reactivation 63.58 10.15 62 152798 3901 63332261
Deep vein thrombosis 63.07 10.15 381 152479 83419 63252743
Injection site reaction 63.01 10.15 31 152829 58493 63277669
Intentional product misuse 63.01 10.15 34 152826 60883 63275279
Rash 62.67 10.15 1780 151080 559091 62777071
Plasmacytoma 62.61 10.15 51 152809 2528 63333634
Toxoplasmosis 61.66 10.15 41 152819 1482 63334680
Acute myeloid leukaemia recurrent 61.65 10.15 42 152818 1581 63334581
Tumour lysis syndrome 59.91 10.15 90 152770 8900 63327262
Respiratory syncytial virus infection 59.75 10.15 79 152781 6939 63329223
Fatigue 59.54 10.15 2658 150202 885370 62450792
Blister 59.41 10.15 141 152719 129673 63206489
Intentional product use issue 58.46 10.15 139 152721 127753 63208409
Aspergillus infection 58.24 10.15 84 152776 8009 63328153
Haemophagocytic lymphohistiocytosis 57.87 10.15 97 152763 10530 63325632
Injury 57.32 10.15 55 152805 73192 63262970
Blood cholesterol increased 57.22 10.15 86 152774 93946 63242216
Liver injury 56.68 10.15 38 152822 60482 63275680
Osteoarthritis 56.29 10.15 89 152771 95254 63240908
Drug resistance 56.16 10.15 151 152709 22782 63313380
Wrong technique in product usage process 55.93 10.15 41 152819 62299 63273863
Pleocytosis 55.47 10.15 31 152829 814 63335348
Pneumonia fungal 55.32 10.15 67 152793 5388 63330774
Enterococcal infection 54.36 10.15 80 152780 7768 63328394
Septic shock 53.40 10.15 308 152552 66321 63269841
Clostridium difficile colitis 52.97 10.15 138 152722 20431 63315731
Chronic graft versus host disease 52.54 10.15 50 152810 3052 63333110
Injection site bruising 51.90 10.15 18 152842 41892 63294270
Thyroxine free increased 51.51 10.15 30 152830 854 63335308
Drug interaction 51.23 10.15 332 152528 228799 63107363
Exposure during pregnancy 51.06 10.15 197 152663 155350 63180812
Injection site erythema 50.67 10.15 76 152784 83098 63253064
Arthritis 50.62 10.15 129 152731 115792 63220370
Lower respiratory tract infection 50.55 10.15 157 152703 132150 63204012
General physical health deterioration 50.18 10.15 282 152578 201120 63135042
Sleep disorder due to a general medical condition 49.53 10.15 98 152762 12090 63324072
Blood thyroid stimulating hormone increased 49.35 10.15 73 152787 7121 63329041
Influenza 49.34 10.15 438 152422 108284 63227878
Sedation 49.22 10.15 16 152844 38793 63297369
Obesity 48.80 10.15 7 152853 29945 63306217
Engraftment syndrome 48.67 10.15 24 152836 484 63335678
Musculoskeletal pain 47.37 10.15 94 152766 92183 63243979
Monocyte count decreased 46.92 10.15 40 152820 2113 63334049
Cardiac disorder 46.83 10.15 244 152616 50572 63285590
Anaphylactic reaction 46.82 10.15 54 152806 66046 63270116
Blood pressure systolic increased 46.80 10.15 28 152832 47369 63288793
Flushing 45.89 10.15 324 152536 74763 63261399
Carpal tunnel syndrome 45.00 10.15 131 152729 20686 63315476
Respiratory failure 44.50 10.15 407 152453 101451 63234711
Factor XIII deficiency 44.42 10.15 14 152846 77 63336085
Intentional self-injury 44.28 10.15 5 152855 25682 63310480
Band sensation 44.04 10.15 27 152833 846 63335316
Rhabdomyolysis 43.35 10.15 26 152834 43925 63292237
Protein urine present 43.28 10.15 63 152797 6057 63330105
Anaemia 43.25 10.15 967 151893 292463 63043699
Suicidal ideation 43.13 10.15 52 152808 62369 63273793
Injection site swelling 43.05 10.15 31 152829 47541 63288621
Haematocrit decreased 42.75 10.15 198 152662 39142 63297020
Aplastic anaemia 42.64 10.15 80 152780 9489 63326673
COVID-19 pneumonia 42.57 10.15 101 152759 14108 63322054
Bacterial sepsis 42.42 10.15 50 152810 3908 63332254
Cystitis haemorrhagic 42.40 10.15 51 152809 4072 63332090
Urinary casts 42.35 10.15 25 152835 730 63335432
Hypothyroidism 42.30 10.15 209 152651 42423 63293739
Thrombotic microangiopathy 41.82 10.15 84 152776 10477 63325685
Prescribed overdose 41.72 10.15 15 152845 34138 63302024
Disseminated mucormycosis 41.33 10.15 16 152844 174 63335988
Rash pruritic 41.31 10.15 266 152594 59533 63276629
Bacteraemia 41.25 10.15 113 152747 17235 63318927
Seasonal allergy 40.73 10.15 127 152733 20823 63315339
Antiviral drug level above therapeutic 40.70 10.15 9 152851 6 63336156
Urine leukocyte esterase 40.13 10.15 15 152845 147 63336015
Pulmonary fibrosis 40.04 10.15 23 152837 39786 63296376
Blood thyroid stimulating hormone decreased 39.59 10.15 52 152808 4538 63331624
Inflammation 39.54 10.15 87 152773 82186 63253976
Renal failure 39.35 10.15 445 152415 117207 63218955
Cells in urine 39.34 10.15 16 152844 200 63335962
Varicella zoster virus infection 39.32 10.15 40 152820 2649 63333513
Dry skin 39.27 10.15 253 152607 56634 63279528
Herpes virus infection 39.01 10.15 57 152803 5499 63330663
Taste disorder 38.66 10.15 95 152765 13567 63322595
Hypoglycaemia 38.44 10.15 53 152807 60012 63276150
Graft versus host disease in gastrointestinal tract 38.19 10.15 43 152817 3198 63332964
Foot deformity 38.04 10.15 10 152850 27843 63308319
Medication error 37.80 10.15 42 152818 52242 63283920
Venoocclusive liver disease 37.48 10.15 52 152808 4783 63331379
Mucormycosis 37.14 10.15 40 152820 2831 63333331
Tooth disorder 36.94 10.15 150 152710 28007 63308155
Graft versus host disease in skin 36.75 10.15 40 152820 2865 63333297
Joint range of motion decreased 36.73 10.15 16 152844 32412 63303750
Myocardial infarction 36.43 10.15 121 152739 99772 63236390
Pain in extremity 36.41 10.15 570 152290 330916 63005246
Injection site pruritus 36.33 10.15 33 152827 45083 63291079
Therapeutic product effect incomplete 36.31 10.15 166 152694 124890 63211272
CD4 lymphocytes decreased 36.30 10.15 29 152831 1398 63334764
Mean cell haemoglobin decreased 36.17 10.15 53 152807 5126 63331036
Leukocyturia 35.91 10.15 29 152831 1420 63334742
Skin exfoliation 35.68 10.15 201 152659 42901 63293261
Dysgeusia 35.53 10.15 213 152647 46497 63289665
Underdose 35.39 10.15 11 152849 27445 63308717
Incorrect route of product administration 35.38 10.15 11 152849 27441 63308721
Multiple allergies 34.93 10.15 92 152768 13710 63322452
Therapeutic response decreased 34.84 10.15 59 152801 61466 63274696
Adenovirus infection 34.82 10.15 43 152817 3528 63332634
Tremor 34.70 10.15 478 152382 131761 63204401
Hypogammaglobulinaemia 34.64 10.15 62 152798 7093 63329069
Skin discolouration 34.41 10.15 181 152679 37647 63298515
Death 34.21 10.15 1160 151700 373221 62962941
Burning sensation 33.96 10.15 236 152624 54171 63281991
CSF protein increased 33.89 10.15 19 152841 502 63335660
Differentiation syndrome 33.71 10.15 25 152835 1078 63335084
Haematotoxicity 32.94 10.15 71 152789 9305 63326857
Rash maculo-papular 32.81 10.15 158 152702 31738 63304424
Haemorrhage intracranial 32.50 10.15 88 152772 13331 63322831
Osteoporosis 32.46 10.15 55 152805 57283 63278879
Diffuse large B-cell lymphoma 32.28 10.15 58 152802 6654 63329508
Sopor 32.15 10.15 7 152853 22157 63314005
Pulmonary thrombosis 31.85 10.15 67 152793 8635 63327527
Bone erosion 31.70 10.15 3 152857 17714 63318448
Congenital nail disorder 30.86 10.15 11 152849 93 63336069
Insomnia 30.63 10.15 706 152154 214546 63121616
Immune thrombocytopenia 30.51 10.15 74 152786 10482 63325680
Vision blurred 30.42 10.15 347 152513 91577 63244585
Hyperbilirubinaemia 30.26 10.15 77 152783 11237 63324925
Weight increased 30.14 10.15 444 152416 260348 63075814
Atrial fibrillation 29.95 10.15 420 152440 116216 63219946
Bursitis 29.93 10.15 27 152833 37014 63299148
CSF oligoclonal band present 29.93 10.15 16 152844 384 63335778
Microtia 29.89 10.15 16 152844 385 63335777
Systemic mycosis 29.75 10.15 24 152836 1173 63334989
Red blood cell count increased 29.58 10.15 37 152823 3075 63333087
Drug dependence 29.49 10.15 11 152849 24472 63311690
Injection site haemorrhage 29.16 10.15 11 152849 24303 63311859
Encephalitis autoimmune 29.15 10.15 26 152834 1460 63334702
Urinary tract infection 29.14 10.15 839 152021 263845 63072317
Specific gravity urine increased 29.14 10.15 13 152847 207 63335955
Post herpetic neuralgia 29.08 10.15 31 152829 2168 63333994
Escherichia bacteraemia 28.96 10.15 41 152819 3842 63332320
Plasma cell leukaemia 28.82 10.15 23 152837 1107 63335055
Device expulsion 28.77 10.15 25 152835 34897 63301265
Blood pressure fluctuation 28.52 10.15 42 152818 46275 63289887
Engraft failure 28.40 10.15 15 152845 351 63335811
Cytomegalovirus hepatitis 28.40 10.15 15 152845 351 63335811
Antinuclear antibody negative 28.37 10.15 13 152847 221 63335941
Acute lymphocytic leukaemia recurrent 28.28 10.15 31 152829 2238 63333924
Mean cell haemoglobin concentration increased 28.27 10.15 17 152843 514 63335648
Urobilinogen urine increased 28.14 10.15 14 152846 288 63335874
Renal impairment 28.11 10.15 331 152529 88024 63248138
Creutzfeldt-Jakob disease 28.10 10.15 12 152848 171 63335991
Cataract 28.04 10.15 234 152626 56819 63279343
Full blood count increased 27.87 10.15 22 152838 1042 63335120
Human chorionic gonadotropin increased 27.71 10.15 26 152834 1559 63334603
Blood pressure diastolic decreased 27.69 10.15 10 152850 22696 63313466
Band neutrophil percentage increased 27.65 10.15 13 152847 235 63335927
Abdominal wall infection 27.41 10.15 10 152850 91 63336071
Escherichia infection 27.32 10.15 80 152780 12674 63323488
Red blood cells urine 27.29 10.15 17 152843 548 63335614
Pregnancy 27.28 10.15 29 152831 36807 63299355
Tri-iodothyronine free decreased 27.20 10.15 14 152846 310 63335852
Pneumonia cytomegaloviral 27.17 10.15 30 152830 2184 63333978
Extravasation 27.15 10.15 31 152829 2341 63333821
Fryns syndrome 27.10 10.15 9 152851 60 63336102
Leukopenia 27.05 10.15 295 152565 76995 63259167
Drug withdrawal syndrome 26.94 10.15 16 152844 27178 63308984
Staphylococcal bacteraemia 26.87 10.15 48 152812 5482 63330680
Lupus-like syndrome 26.31 10.15 3 152857 15292 63320870
Metastases to liver 26.24 10.15 12 152848 23627 63312535
Partial seizures 26.23 10.15 49 152811 5793 63330369
Pneumonia bacterial 25.92 10.15 65 152795 9400 63326762
Clostridium difficile infection 25.74 10.15 141 152719 29781 63306381
Primary myelofibrosis 25.68 10.15 9 152851 72 63336090
Tri-iodothyronine free increased 25.67 10.15 12 152848 214 63335948
Epstein-Barr virus associated lymphoproliferative disorder 25.58 10.15 27 152833 1867 63334295
Coombs positive haemolytic anaemia 25.42 10.15 14 152846 357 63335805
Device malfunction 25.18 10.15 6 152854 17851 63318311
Hepatitis fulminant 24.99 10.15 36 152824 3428 63332734
Oxygen saturation decreased 24.88 10.15 119 152741 88466 63247696
Agranulocytosis 24.77 10.15 123 152737 25011 63311151
Acute graft versus host disease in liver 24.63 10.15 17 152843 654 63335508
Accidental exposure to product 24.61 10.15 18 152842 27387 63308775
Hypoaesthesia 24.47 10.15 554 152306 167839 63168323
Pneumonia influenzal 24.37 10.15 25 152835 1672 63334490
Dilatation intrahepatic duct acquired 24.29 10.15 17 152843 669 63335493
Abortion spontaneous 24.28 10.15 48 152812 47147 63289015
Off label use 24.21 10.15 1353 151507 673109 62663053
Urine oxalate increased 23.98 10.15 12 152848 250 63335912
Status epilepticus 23.98 10.15 86 152774 15147 63321015
Migraine 23.97 10.15 148 152712 103198 63232964
Brain oedema 23.95 10.15 82 152778 14113 63322049
Blood brain barrier defect 23.92 10.15 9 152851 90 63336072
Multiple sclerosis relapse 23.92 10.15 199 152661 48279 63287883
Infusion site pain 23.85 10.15 92 152768 16777 63319385
Obstructive airways disorder 23.78 10.15 10 152850 20689 63315473
Venoocclusive disease 23.73 10.15 27 152833 2031 63334131
Blood bilirubin increased 23.71 10.15 162 152698 36978 63299184
CSF measles antibody positive 23.63 10.15 8 152852 57 63336105
Prescribed underdose 23.56 10.15 22 152838 29667 63306495
Sleep apnoea syndrome 23.55 10.15 135 152725 28998 63307164
Staphylococcal sepsis 23.51 10.15 57 152803 8071 63328091
Anti-thyroid antibody positive 23.50 10.15 14 152846 416 63335746
Premature delivery 23.38 10.15 23 152837 30258 63305904
Adverse drug reaction 23.34 10.15 294 152566 79420 63256742
Gastrointestinal disorder 23.20 10.15 203 152657 131036 63205126
Monoclonal immunoglobulin present 23.17 10.15 18 152842 833 63335329
Herpes simplex encephalitis 23.10 10.15 13 152847 346 63335816
Congenital diaphragmatic hernia 22.99 10.15 11 152849 207 63335955
Lymph node palpable 22.92 10.15 9 152851 102 63336060
Spinal fracture 22.92 10.15 96 152764 18175 63317987
Rubella antibody positive 22.83 10.15 8 152852 64 63336098
Live birth 22.80 10.15 17 152843 25613 63310549
Myelocyte count increased 22.74 10.15 13 152847 357 63335805
Graft versus host disease in liver 22.61 10.15 16 152844 641 63335521
Breast cancer 22.56 10.15 52 152808 48331 63287831
Eczema herpeticum 22.43 10.15 10 152850 159 63336003
International normalised ratio increased 22.38 10.15 49 152811 46376 63289786
Ulcer 22.36 10.15 18 152842 26089 63310073
Toxic epidermal necrolysis 22.21 10.15 120 152740 25214 63310948
Magnetic resonance imaging abnormal 22.17 10.15 32 152828 3053 63333109
Dyslalia 22.16 10.15 14 152846 463 63335699
COVID-19 22.09 10.15 389 152471 112714 63223448
Hordeolum 22.00 10.15 33 152827 3259 63332903
Red cell distribution width decreased 21.99 10.15 26 152834 2039 63334123
Band neutrophil count increased 21.95 10.15 13 152847 382 63335780
Extrapyramidal disorder 21.89 10.15 3 152857 13281 63322881
Bradycardia 21.84 10.15 271 152589 72956 63263206
Target skin lesion 21.81 10.15 9 152851 117 63336045
Thyroxine free decreased 21.74 10.15 16 152844 682 63335480
pH urine increased 21.74 10.15 13 152847 389 63335773
Joint dislocation 21.73 10.15 9 152851 18791 63317371
Rash papular 21.68 10.15 85 152775 15617 63320545
Pulmonary arterial hypertension 21.37 10.15 14 152846 22563 63313599
Pulmonary mucormycosis 21.27 10.15 12 152848 321 63335841
Cytokine storm 21.17 10.15 12 152848 324 63335838
Tonsillar haemorrhage 21.12 10.15 11 152849 250 63335912
Systemic candida 20.93 10.15 32 152828 3213 63332949
Device difficult to use 20.82 10.15 3 152857 12793 63323369
Tenosynovitis 20.75 10.15 4 152856 13791 63322371
Chills 20.75 10.15 386 152474 112992 63223170
Focal myositis 20.59 10.15 6 152854 24 63336138
Pulmonary embolism 20.58 10.15 395 152465 116289 63219873
Monoclonal immunoglobulin increased 20.54 10.15 9 152851 137 63336025
Therapy interrupted 20.40 10.15 29 152831 32426 63303736
Corneal lesion 20.40 10.15 6 152854 25 63336137
Depression 20.18 10.15 342 152518 196150 63140012
Myelocyte percentage increased 20.17 10.15 10 152850 204 63335958
Ophthalmic herpes simplex 20.13 10.15 13 152847 447 63335715
Chronic lymphocytic leukaemia 20.09 10.15 28 152832 2586 63333576
Herpes simplex reactivation 19.93 10.15 14 152846 554 63335608
Oral herpes 19.89 10.15 119 152741 25955 63310207
Klebsiella test positive 19.85 10.15 19 152841 1168 63334994
Lactic acidosis 19.64 10.15 39 152821 38248 63297914
Product dose omission issue 19.62 10.15 719 152141 233594 63102568
Immune system disorder 19.47 10.15 60 152800 9774 63326388
Macular degeneration 19.42 10.15 18 152842 24358 63311804
Thyroid stimulating immunoglobulin 19.35 10.15 7 152853 62 63336100
Hyperuricaemia 19.25 10.15 41 152819 5329 63330833
Neutropenic colitis 19.24 10.15 30 152830 3065 63333097
Dehydration 19.20 10.15 550 152310 172804 63163358
Surgery 18.93 10.15 36 152824 35876 63300286
Therapeutic response shortened 18.86 10.15 3 152857 11885 63324277
Haemorrhagic disorder 18.85 10.15 16 152844 840 63335322
Hepatic cirrhosis 18.85 10.15 19 152841 24715 63311447
Lactose intolerance 18.70 10.15 29 152831 2949 63333213
Mean cell volume decreased 18.66 10.15 34 152826 3944 63332218
Disseminated intravascular coagulation 18.61 10.15 93 152767 18958 63317204
Peripheral venous disease 18.56 10.15 7 152853 15470 63320692
Therapy non-responder 18.49 10.15 107 152753 75794 63260368
Injection site mass 18.45 10.15 11 152849 18645 63317517
Blood thyroid stimulating hormone abnormal 18.41 10.15 16 152844 868 63335294
Pseudomonas infection 18.24 10.15 64 152796 11149 63325013
Anaphylactic shock 18.19 10.15 18 152842 23615 63312547
Meningitis listeria 18.07 10.15 14 152846 645 63335517
Blood pressure increased 17.99 10.15 278 152582 161784 63174378
Myeloblast percentage decreased 17.94 10.15 6 152854 41 63336121
Thyroid stimulating immunoglobulin increased 17.93 10.15 7 152853 78 63336084
Ear swelling 17.83 10.15 20 152840 1481 63334681
Creatinine urine decreased 17.83 10.15 9 152851 191 63335971
Hypoglossal nerve paralysis 17.79 10.15 5 152855 17 63336145
Pneumonia parainfluenzae viral 17.77 10.15 7 152853 80 63336082
Acute generalised exanthematous pustulosis 17.76 10.15 63 152797 11036 63325126
Lipaemic index score 17.70 10.15 7 152853 81 63336081
Craniofacial deformity 17.62 10.15 8 152852 133 63336029
Sciatica 17.58 10.15 35 152825 34289 63301873
Sepsis syndrome 17.53 10.15 16 152844 926 63335236
White blood cells urine 17.47 10.15 12 152848 458 63335704
Tendonitis 17.46 10.15 13 152847 19602 63316560
Eosinophil count increased 17.46 10.15 62 152798 10866 63325296
Rash macular 17.42 10.15 106 152754 23258 63312904
Body temperature decreased 17.41 10.15 14 152846 20305 63315857
Bilirubin urine present 17.39 10.15 7 152853 85 63336077
Abdominal wall wound 17.39 10.15 7 152853 85 63336077
Small intestine adenocarcinoma 17.36 10.15 5 152855 19 63336143
Herpes simplex pneumonia 17.36 10.15 5 152855 19 63336143
Jarisch-Herxheimer reaction 17.35 10.15 11 152849 366 63335796
Acute disseminated encephalomyelitis 17.34 10.15 9 152851 203 63335959
Blood creatinine decreased 17.25 10.15 40 152820 5505 63330657
Pulmonary hypoplasia 17.22 10.15 10 152850 283 63335879
Right ventricular failure 17.18 10.15 10 152850 17178 63318984
Posterior reversible encephalopathy syndrome 17.18 10.15 85 152775 17260 63318902
Product quality issue 17.17 10.15 38 152822 35827 63300335
Mean cell haemoglobin concentration decreased 17.10 10.15 31 152829 3581 63332581
Procedural pain 17.10 10.15 16 152844 21553 63314609
Neutrophil count increased 17.09 10.15 82 152778 16445 63319717
Feeling hot 17.07 10.15 191 152669 50163 63285999
Lip dry 16.94 10.15 8 152852 15462 63320700
Immunosuppressant drug level increased 16.94 10.15 31 152829 3607 63332555
Vaginal cellulitis 16.90 10.15 7 152853 92 63336070
Glomerulonephritis chronic 16.85 10.15 8 152852 148 63336014
Diabetes mellitus 16.84 10.15 73 152787 55737 63280425
Body height decreased 16.81 10.15 58 152802 10020 63326142
Nephropathy 16.80 10.15 43 152817 6298 63329864
Eosinophil percentage decreased 16.80 10.15 9 152851 217 63335945
Serotonin syndrome 16.71 10.15 27 152833 28655 63307507
Mantle cell lymphoma 16.67 10.15 12 152848 494 63335668
Mental status changes 16.66 10.15 157 152703 39442 63296720
Thunderclap headache 16.61 10.15 9 152851 222 63335940
Bone marrow transplant 16.61 10.15 14 152846 728 63335434
Lung infiltration 16.61 10.15 74 152786 14389 63321773
Nervous system disorder 16.53 10.15 89 152771 18677 63317485
Acute lymphocytic leukaemia 16.50 10.15 25 152835 2491 63333671
Antineutrophil cytoplasmic antibody positive 16.45 10.15 13 152847 617 63335545
Meningitis aseptic 16.35 10.15 36 152824 4787 63331375
Angioimmunoblastic T-cell lymphoma 16.31 10.15 7 152853 101 63336061
CSF test abnormal 16.23 10.15 10 152850 316 63335846
Mitochondrial DNA mutation 16.22 10.15 11 152849 411 63335751
Drug reaction with eosinophilia and systemic symptoms 16.21 10.15 138 152722 33698 63302464
Peripheral sensory neuropathy 16.21 10.15 47 152813 7404 63328758
Alanine aminotransferase increased 16.21 10.15 345 152515 103425 63232737
Metastases to bone 16.19 10.15 16 152844 21003 63315159
Autoimmune thyroiditis 16.14 10.15 32 152828 3954 63332208
Premature labour 16.13 10.15 5 152855 12499 63323663
Toxic neuropathy 16.08 10.15 11 152849 417 63335745
Capillary leak syndrome 16.07 10.15 23 152837 2177 63333985
Gastritis fungal 16.07 10.15 7 152853 105 63336057
Blood lactate dehydrogenase increased 16.06 10.15 103 152757 23013 63313149
Monocyte percentage decreased 15.98 10.15 9 152851 240 63335922
Pseudomonal sepsis 15.95 10.15 24 152836 2377 63333785
Listeriosis 15.95 10.15 19 152841 1502 63334660
Injection site urticaria 15.85 10.15 7 152853 14066 63322096
Ankylosing spondylitis 15.83 10.15 3 152857 10471 63325691
Autoimmune disorder 15.79 10.15 11 152849 17166 63318996
Hypercholesterolaemia 15.57 10.15 17 152843 21317 63314845
Rhinovirus infection 15.57 10.15 34 152826 4495 63331667
Bacterial infection 15.52 10.15 90 152770 19409 63316753
Increased tendency to bruise 15.29 10.15 58 152802 10494 63325668
Disability 15.28 10.15 13 152847 18334 63317828
Refractoriness to platelet transfusion 15.23 10.15 5 152855 32 63336130
Angina pectoris 15.12 10.15 31 152829 30047 63306115
Basophil percentage decreased 15.10 10.15 3 152857 0 63336162
Weight decreased 15.09 10.15 530 152330 276268 63059894
Gait disturbance 15.08 10.15 331 152529 182847 63153315
Eye swelling 15.07 10.15 104 152756 23814 63312348
Geotrichum infection 15.07 10.15 11 152849 463 63335699
Lung neoplasm malignant 15.06 10.15 15 152845 19618 63316544
Amyloidosis 15.01 10.15 16 152844 1119 63335043
Pneumonia pseudomonal 14.98 10.15 24 152836 2509 63333653
Factor XIII Inhibition 14.97 10.15 5 152855 34 63336128
Leukaemia 14.94 10.15 32 152828 4176 63331986
Bone pain 14.93 10.15 199 152661 54442 63281720
Metastases to lung 14.91 10.15 6 152854 12744 63323418
Injection site rash 14.85 10.15 14 152846 18795 63317367
Chest discomfort 14.80 10.15 358 152502 109611 63226551
Viral haemorrhagic cystitis 14.70 10.15 14 152846 855 63335307
Delayed engraftment 14.67 10.15 7 152853 131 63336031
Tumour flare 14.64 10.15 10 152850 378 63335784
Organic brain syndrome 14.56 10.15 8 152852 203 63335959
Blood pressure systolic abnormal 14.54 10.15 7 152853 13379 63322783
Pneumonia pneumococcal 14.51 10.15 22 152838 2193 63333969
Avulsion fracture 14.51 10.15 9 152851 288 63335874
Haemodialysis 14.50 10.15 51 152809 8896 63327266
Sleep disorder 14.48 10.15 126 152734 81440 63254722
Exostosis 14.46 10.15 13 152847 17849 63318313
Joint stiffness 14.39 10.15 52 152808 41817 63294345
Culture stool positive 14.37 10.15 9 152851 293 63335869
Herpes zoster meningoencephalitis 14.32 10.15 9 152851 295 63335867
Hypokalaemia 14.29 10.15 339 152521 103465 63232697
Rectal haemorrhage 14.27 10.15 65 152795 48965 63287197
Caesarean section 14.26 10.15 12 152848 17020 63319142
Muscle rigidity 14.13 10.15 5 152855 11495 63324667
Fumbling 14.11 10.15 7 152853 143 63336019
Infusion site scar 14.08 10.15 11 152849 513 63335649
Obliterative bronchiolitis 14.00 10.15 21 152839 2074 63334088
Ureaplasma infection 13.99 10.15 12 152848 639 63335523
Gastrooesophageal reflux disease 13.99 10.15 315 152545 95324 63240838
Panniculitis 13.91 10.15 5 152855 11380 63324782
Arteritis infective 13.85 10.15 5 152855 44 63336118
Toxic encephalopathy 13.83 10.15 41 152819 6538 63329624
Blastomycosis 13.82 10.15 9 152851 314 63335848
Housebound 13.79 10.15 8 152852 226 63335936
Periorbital swelling 13.76 10.15 25 152835 2893 63333269
Duodenal stenosis 13.75 10.15 11 152849 531 63335631
Orthostatic hypotension 13.74 10.15 43 152817 36117 63300045
White blood cell disorder 13.62 10.15 23 152837 2511 63333651
Joint injury 13.61 10.15 32 152828 29540 63306622
Metabolic acidosis 13.57 10.15 59 152801 45010 63291152
Basophil count increased 13.57 10.15 14 152846 943 63335219
Model for end stage liver disease score increased 13.53 10.15 4 152856 17 63336145
Oesophageal atresia 13.53 10.15 11 152849 544 63335618
Meningitis 13.48 10.15 43 152817 7134 63329028
Serum ferritin increased 13.45 10.15 39 152821 6143 63330019
Infusion site discomfort 13.44 10.15 17 152843 1429 63334733
Skin disorder 13.44 10.15 119 152741 29388 63306774
Blast cell count increased 13.39 10.15 10 152850 436 63335726
Refractory anaemia with an excess of blasts 13.37 10.15 10 152850 437 63335725
Diarrhoea haemorrhagic 13.35 10.15 50 152810 8992 63327170
Incorrect dose administered 13.32 10.15 87 152773 59881 63276281
Staphylococcal infection 13.31 10.15 155 152705 41101 63295061
Device issue 13.28 10.15 23 152837 23758 63312404
Monocyte count increased 13.27 10.15 44 152816 7449 63328713
Pneumococcal sepsis 13.24 10.15 12 152848 688 63335474
Erythema multiforme 13.20 10.15 54 152806 10115 63326047
Malignant sweat gland neoplasm 13.18 10.15 4 152856 19 63336143
Gastroenteritis salmonella 13.14 10.15 12 152848 695 63335467
Staphylococcus test positive 13.11 10.15 29 152831 3867 63332295
Frequent bowel movements 13.10 10.15 22 152838 23000 63313162
Neuralgia 13.09 10.15 107 152753 25819 63310343
Hypoaesthesia oral 13.00 10.15 64 152796 12969 63323193
Chronic hepatitis B 13.00 10.15 9 152851 348 63335814
Klebsiella bacteraemia 12.94 10.15 18 152842 1660 63334502
Idiopathic pneumonia syndrome 12.93 10.15 9 152851 351 63335811
Tracheo-oesophageal fistula 12.90 10.15 11 152849 581 63335581
Fall 12.78 10.15 794 152066 391540 62944622
Blood loss anaemia 12.74 10.15 3 152857 8998 63327164
Eosinophil percentage increased 12.72 10.15 14 152846 1015 63335147
Hepatosplenic candidiasis 12.70 10.15 8 152852 263 63335899
Contusion 12.67 10.15 270 152590 149774 63186388
Coronary artery disease 12.65 10.15 38 152822 32339 63303823
Asthenia 12.64 10.15 1080 151780 382524 62953638
Acquired macroglossia 12.62 10.15 7 152853 181 63335981
Device breakage 12.59 10.15 6 152854 11536 63324626
No adverse event 12.59 10.15 54 152806 41351 63294811
Sinusitis 12.58 10.15 433 152427 226220 63109942
Red blood cell abnormality 12.57 10.15 10 152850 479 63335683
Tachycardia 12.56 10.15 373 152487 117783 63218379
Viral skin infection 12.54 10.15 4 152856 23 63336139
Back pain 12.53 10.15 766 152094 263379 63072783
Dystonia 12.51 10.15 9 152851 13810 63322352
Injection site warmth 12.37 10.15 11 152849 15184 63320978
Bone marrow failure 12.26 10.15 116 152744 29174 63306988
Diabetic ketoacidosis 12.23 10.15 19 152841 20486 63315676
Sinus disorder 12.22 10.15 101 152759 24452 63311710
Injection site phlebitis 12.17 10.15 6 152854 121 63336041
Congenital syphilis 12.16 10.15 3 152857 5 63336157
Poor quality sleep 12.16 10.15 86 152774 19849 63316313
Retinal depigmentation 12.13 10.15 8 152852 285 63335877
Metapneumovirus pneumonia 12.13 10.15 4 152856 26 63336136
Oesophageal irritation 12.08 10.15 6 152854 123 63336039
Fusarium infection 12.07 10.15 11 152849 635 63335527
Nocardiosis 12.07 10.15 19 152841 1957 63334205
Antiphospholipid syndrome 12.04 10.15 18 152842 1772 63334390
Joint effusion 12.01 10.15 14 152846 17046 63319116
Hiatus hernia 11.96 10.15 21 152839 21573 63314589
Enthesopathy 11.94 10.15 3 152857 8611 63327551
Blood gases abnormal 11.92 10.15 12 152848 785 63335377
Mycobacterium kansasii infection 11.90 10.15 6 152854 127 63336035
Central nervous system lesion 11.90 10.15 54 152806 10581 63325581
Cytomegalovirus gastroenteritis 11.90 10.15 7 152853 203 63335959
Phyllodes tumour 11.88 10.15 4 152856 28 63336134
Cardio-respiratory arrest 11.85 10.15 90 152770 59869 63276293
Dyspnoea 11.84 10.15 1403 151457 659910 62676252
Mycobacterium abscessus infection 11.82 10.15 11 152849 653 63335509
Viral oesophagitis 11.81 10.15 3 152857 6 63336156
Acute HIV infection 11.81 10.15 3 152857 6 63336156
Labelled drug-drug interaction medication error 11.77 10.15 9 152851 13390 63322772
Immature granulocyte count increased 11.72 10.15 9 152851 409 63335753
Allergy to arthropod bite 11.65 10.15 8 152852 305 63335857
Gastrointestinal haemorrhage 11.65 10.15 132 152728 81044 63255118
Atypical pneumonia 11.65 10.15 30 152830 4410 63331752
Renal tubular necrosis 11.61 10.15 58 152802 11820 63324342
Encephalitis brain stem 11.61 10.15 6 152854 134 63336028
Impaired work ability 11.61 10.15 15 152845 17460 63318702
Cytomegalovirus enterocolitis 11.58 10.15 11 152849 670 63335492
Ingrowing nail 11.57 10.15 21 152839 2428 63333734
Herpes ophthalmic 11.55 10.15 15 152845 1294 63334868
Full blood count abnormal 11.53 10.15 122 152738 31595 63304567
Anti-thyroid antibody 11.53 10.15 4 152856 31 63336131
Non-Hodgkin's lymphoma recurrent 11.50 10.15 3 152857 7 63336155
Nystagmus 11.44 10.15 37 152823 6183 63329979
Myositis 11.44 10.15 4 152856 9262 63326900
Gastroenteritis norovirus 11.43 10.15 19 152841 2049 63334113
Spinal compression fracture 11.42 10.15 66 152794 14217 63321945
Salmonella test positive 11.41 10.15 4 152856 32 63336130
Disseminated cryptococcosis 11.41 10.15 9 152851 426 63335736
Injection site induration 11.36 10.15 4 152856 9222 63326940
Genital rash 11.32 10.15 10 152850 554 63335608
Gingival bleeding 11.29 10.15 60 152800 12527 63323635
Dust allergy 11.27 10.15 11 152849 693 63335469
Urinary tract infection enterococcal 11.25 10.15 22 152838 2691 63333471
Tendon rupture 11.17 10.15 3 152857 8236 63327926
Pallor 11.16 10.15 37 152823 30531 63305631
Treatment noncompliance 11.15 10.15 49 152811 37276 63298886
Nodule 11.15 10.15 21 152839 21005 63315157
Herpes simplex viraemia 11.14 10.15 8 152852 328 63335834
Varicella 11.09 10.15 18 152842 1903 63334259
Hallucination, visual 11.05 10.15 82 152778 19216 63316946
Stevens-Johnson syndrome 11.04 10.15 100 152760 24850 63311312
Malaise 11.03 10.15 857 152003 415097 62921065
Large intestine infection 11.02 10.15 18 152842 1912 63334250
Pancreatitis viral 10.96 10.15 3 152857 9 63336153
Tri-iodothyronine free abnormal 10.91 10.15 4 152856 37 63336125
Hepatitis B antibody positive 10.91 10.15 4 152856 37 63336125
Varicella virus test positive 10.90 10.15 6 152854 153 63336009
Protein total increased 10.89 10.15 22 152838 2755 63333407
Human herpesvirus 6 encephalitis 10.85 10.15 7 152853 240 63335922
Pulmonary sepsis 10.82 10.15 16 152844 1560 63334602
Chronic sinusitis 10.82 10.15 9 152851 12834 63323328
Immature granulocyte percentage increased 10.81 10.15 4 152856 38 63336124
Transplant failure 10.75 10.15 16 152844 1569 63334593
Klebsiella infection 10.74 10.15 45 152815 8521 63327641
Vibration test abnormal 10.72 10.15 4 152856 39 63336123
Aspartate aminotransferase increased 10.71 10.15 289 152571 89988 63246174
Eye infection viral 10.69 10.15 6 152854 159 63336003
Feeling abnormal 10.68 10.15 448 152412 147944 63188218
Campylobacter gastroenteritis 10.65 10.15 9 152851 470 63335692
Cerebral artery stenosis 10.63 10.15 9 152851 471 63335691
Transfusion reaction 10.59 10.15 13 152847 1060 63335102
Iron deficiency anaemia 10.54 10.15 20 152840 19949 63316213
Muscle spasticity 10.51 10.15 23 152837 21771 63314391
Neuropsychiatric syndrome 10.46 10.15 4 152856 42 63336120
Infrapatellar fat pad inflammation 10.42 10.15 6 152854 167 63335995
Body temperature increased 10.39 10.15 136 152724 37056 63299106
Escherichia sepsis 10.34 10.15 31 152829 4976 63331186
Pneumocystis jirovecii pneumonia 10.33 10.15 73 152787 16841 63319321
Congenital tricuspid valve incompetence 10.31 10.15 5 152855 97 63336065
Pupillary block 10.30 10.15 3 152857 12 63336150
Bilirubin urine 10.30 10.15 3 152857 12 63336150
Respiratory arrest 10.28 10.15 42 152818 32603 63303559

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 1393.68 10.96 1211 133182 40826 34781712
White blood cell count decreased 521.46 10.96 1140 133253 94305 34728233
Pneumonia 502.78 10.96 2726 131667 359901 34462637
Neuropathy peripheral 499.23 10.96 1033 133360 82230 34740308
Febrile neutropenia 494.24 10.96 1395 132998 135454 34687084
Platelet count decreased 450.48 10.96 1239 133154 118478 34704060
Cytokine release syndrome 377.96 10.96 453 133940 22424 34800114
Drug abuse 354.84 10.96 5 134388 99091 34723447
Full blood count decreased 335.24 10.96 380 134013 17708 34804830
Pyrexia 319.24 10.96 2279 132114 330734 34491804
Neutropenia 315.48 10.96 1315 133078 155463 34667075
Completed suicide 290.53 10.96 23 134370 98145 34724393
Neurotoxicity 270.58 10.96 340 134053 17670 34804868
Toxicity to various agents 264.60 10.96 229 134164 200133 34622405
Thrombosis 263.08 10.96 592 133801 49866 34772672
Neutrophil count decreased 251.42 10.96 586 133807 50518 34772020
Rash 242.35 10.96 1574 132819 221178 34601360
Graft versus host disease 206.01 10.96 228 134165 10341 34812197
Drug interaction 185.53 10.96 368 134025 225578 34596960
Cytomegalovirus infection 176.38 10.96 341 134052 25794 34796744
Laboratory test abnormal 171.87 10.96 293 134100 20098 34802440
Fatigue 169.28 10.96 2169 132224 368484 34454054
Adverse drug reaction 166.16 10.96 356 134037 28986 34793552
Pancytopenia 149.79 10.96 743 133650 94414 34728124
Thrombocytopenia 146.37 10.96 1065 133328 155182 34667356
Intentional product misuse 139.73 10.96 9 134384 45602 34776936
Acute graft versus host disease 124.51 10.96 139 134254 6364 34816174
Intentional overdose 114.38 10.96 16 134377 43658 34778880
Acute graft versus host disease in skin 109.73 10.96 117 134276 5084 34817454
Diarrhoea 105.96 10.96 2093 132300 387819 34434719
Deep vein thrombosis 104.40 10.96 512 133881 64736 34757802
Overdose 101.80 10.96 120 134273 90939 34731599
Sepsis 97.63 10.96 1024 133369 165537 34657001
Cytomegalovirus viraemia 97.12 10.96 131 134262 7299 34815239
Meningoencephalitis herpetic 96.04 10.96 52 134341 783 34821755
Influenza 94.44 10.96 410 133983 49256 34773282
Rheumatoid arthritis 93.40 10.96 17 134376 38221 34784317
Suicide attempt 92.14 10.96 19 134374 39097 34783441
Hypoglycaemia 91.31 10.96 48 134345 54592 34767946
Tooth disorder 88.57 10.96 154 134239 10728 34811810
Plasma cell myeloma recurrent 88.17 10.96 97 134296 4368 34818170
Bronchopulmonary aspergillosis 86.60 10.96 181 134212 14478 34808060
Inappropriate schedule of product administration 83.50 10.96 70 134323 62226 34760312
Constipation 82.99 10.96 848 133545 136134 34686404
Herpes simplex 78.81 10.96 102 134291 5457 34817081
Cystitis haemorrhagic 78.64 10.96 103 134290 5576 34816962
Chronic lymphocytic leukaemia 78.53 10.96 89 134304 4143 34818395
Injection site pain 78.46 10.96 26 134367 38979 34783559
Muscle spasms 77.56 10.96 524 133869 74477 34748061
Infection 77.26 10.96 606 133787 90309 34732229
Lymphocyte count decreased 75.91 10.96 225 134168 22397 34800141
Encephalitis 75.56 10.96 115 134278 7162 34815376
Immune effector cell-associated neurotoxicity syndrome 73.90 10.96 81 134312 3632 34818906
Acute graft versus host disease in intestine 73.82 10.96 70 134323 2638 34819900
Suicidal ideation 72.79 10.96 32 134361 40356 34782182
International normalised ratio increased 72.77 10.96 46 134347 47281 34775257
Wrong technique in product usage process 72.36 10.96 24 134369 35962 34786576
Herpes zoster 71.63 10.96 292 134101 34107 34788431
Drug dependence 70.68 10.96 6 134387 24211 34798327
Tumour lysis syndrome 69.40 10.96 182 134211 16877 34805661
Toxic encephalopathy 69.30 10.96 93 134300 5156 34817382
Post transplant lymphoproliferative disorder 68.97 10.96 104 134289 6424 34816114
Myocardial infarction 68.04 10.96 238 134155 120847 34701691
Acute myeloid leukaemia recurrent 66.73 10.96 60 134333 2110 34820428
Chronic graft versus host disease 66.36 10.96 83 134310 4290 34818248
Epstein-Barr virus infection 66.10 10.96 111 134282 7517 34815021
Acute myeloid leukaemia 65.42 10.96 186 134207 18084 34804454
Rhabdomyolysis 64.86 10.96 101 134292 68062 34754476
Arthralgia 64.63 10.96 386 134007 169655 34652883
Light chain analysis increased 64.58 10.96 49 134344 1352 34821186
Psoriasis 63.51 10.96 35 134358 38777 34783761
Mucosal inflammation 62.41 10.96 304 134089 38318 34784220
Encephalitis viral 61.71 10.96 45 134348 1167 34821371
Bradycardia 60.72 10.96 124 134269 75294 34747244
Drug ineffective 59.12 10.96 1323 133070 455428 34367110
Septic shock 58.37 10.96 474 133919 71360 34751178
Anxiety 58.18 10.96 192 134201 99236 34723302
Condition aggravated 57.90 10.96 467 133926 191729 34630809
Haematotoxicity 57.83 10.96 109 134284 8085 34814453
Plasmacytoma 57.52 10.96 71 134322 3620 34818918
Ageusia 55.97 10.96 123 134270 10185 34812353
Cardio-respiratory arrest 55.40 10.96 79 134314 55194 34767344
Hyperkalaemia 55.09 10.96 115 134278 69274 34753264
Red blood cell count decreased 53.64 10.96 238 134155 28852 34793686
Renal disorder 53.60 10.96 217 134176 25263 34797275
Cytomegalovirus infection reactivation 53.31 10.96 81 134312 5037 34817501
Dyspnoea 53.16 10.96 1076 133317 375706 34446832
Adenovirus infection 53.07 10.96 82 134311 5175 34817363
Cytopenia 53.04 10.96 137 134256 12586 34809952
Blood pressure increased 53.02 10.96 168 134225 87934 34734604
Therapeutic product effect incomplete 52.90 10.96 70 134323 50471 34772067
Body height decreased 52.13 10.96 69 134324 3774 34818764
Pneumonia fungal 52.04 10.96 96 134297 7004 34815534
Acute myocardial infarction 51.67 10.96 79 134314 53640 34768898
Contraindicated product administered 51.49 10.96 10 134383 21471 34801067
Cardiogenic shock 51.37 10.96 19 134374 26599 34795939
Angioedema 50.07 10.96 42 134351 37332 34785206
Cytomegalovirus test positive 50.00 10.96 68 134325 3818 34818720
Gastrointestinal haemorrhage 48.95 10.96 175 134218 88302 34734236
Taste disorder 47.81 10.96 93 134300 7062 34815476
Neutropenic sepsis 47.20 10.96 138 134255 13629 34808909
Necrotising retinitis 46.86 10.96 33 134360 809 34821729
Depression 46.14 10.96 204 134189 96894 34725644
Psoriatic arthropathy 45.83 10.96 10 134383 19788 34802750
Blood pressure fluctuation 45.50 10.96 20 134373 25229 34797309
Venoocclusive liver disease 45.47 10.96 97 134296 7869 34814669
Cardiac arrest 45.10 10.96 203 134190 95956 34726582
Pathogen resistance 44.69 10.96 107 134286 9375 34813163
Stress 44.61 10.96 31 134362 30316 34792222
Sedation 44.03 10.96 13 134380 20993 34801545
Drug resistance 43.99 10.96 207 134186 25720 34796818
Nephropathy toxic 43.95 10.96 127 134266 12461 34810077
Pneumonia cytomegaloviral 43.23 10.96 56 134337 2998 34819540
Labelled drug-drug interaction medication error 42.79 10.96 4 134389 14935 34807603
Interstitial lung disease 42.50 10.96 120 134273 65162 34757376
Respiratory depression 42.41 10.96 6 134387 16239 34806299
Brain stem stroke 42.29 10.96 22 134371 304 34822234
Respiratory arrest 42.09 10.96 28 134365 28015 34794523
Parainfluenzae virus infection 41.81 10.96 53 134340 2777 34819761
Electrocardiogram QT prolonged 41.56 10.96 58 134335 40894 34781644
Encephalopathy 41.54 10.96 255 134138 35064 34787474
COVID-19 pneumonia 41.00 10.96 151 134242 16816 34805722
Thrombotic microangiopathy 40.80 10.96 111 134282 10519 34812019
Blood pressure systolic increased 40.08 10.96 19 134374 22933 34799605
Unevaluable event 40.05 10.96 238 134155 32352 34790186
Organic brain syndrome 39.79 10.96 20 134373 256 34822282
Pulmonary thrombosis 39.78 10.96 88 134305 7319 34815219
Ophthalmic herpes simplex 39.21 10.96 21 134372 309 34822229
Abdominal pain 39.14 10.96 421 133972 163197 34659341
Full blood count increased 38.80 10.96 30 134363 852 34821686
Foetal exposure during pregnancy 38.63 10.96 54 134339 38047 34784491
Intentional self-injury 38.62 10.96 4 134389 13767 34808771
Drug withdrawal syndrome 38.54 10.96 14 134379 19820 34802718
Asthma 37.96 10.96 66 134327 42590 34779948
Somnolence 37.70 10.96 261 134132 110855 34711683
Fusarium infection 37.51 10.96 33 134360 1127 34821411
Protein total increased 37.27 10.96 45 134348 2242 34820296
Acute lymphocytic leukaemia recurrent 37.26 10.96 52 134341 2992 34819546
Blood bilirubin increased 36.86 10.96 263 134130 38033 34784505
Blood creatine phosphokinase increased 36.74 10.96 73 134320 44784 34777754
Seasonal allergy 36.63 10.96 80 134313 6595 34815943
Engraft failure 36.57 10.96 23 134370 464 34822074
Stem cell transplant 36.36 10.96 43 134350 2096 34820442
Crystal urine present 36.22 10.96 23 134370 472 34822066
Coronary artery disease 35.91 10.96 83 134310 48222 34774316
Rash pruritic 35.88 10.96 201 134192 26740 34795798
COVID-19 35.57 10.96 455 133938 77095 34745443
Lactic acidosis 35.53 10.96 49 134344 34723 34787815
Herpes virus infection 35.46 10.96 49 134344 2793 34819745
Drug hypersensitivity 35.40 10.96 174 134219 80355 34742183
Clostridium difficile infection 35.13 10.96 155 134238 18743 34803795
Cellulitis enterococcal 35.05 10.96 14 134379 99 34822439
Aggression 34.93 10.96 60 134333 38904 34783634
Diffuse large B-cell lymphoma 34.55 10.96 83 134310 7287 34815251
Acute graft versus host disease in liver 34.40 10.96 36 134357 1530 34821008
Hyperbilirubinaemia 34.28 10.96 142 134251 16701 34805837
Human herpesvirus 6 infection 34.00 10.96 41 134352 2040 34820498
General physical health deterioration 33.57 10.96 323 134070 127946 34694592
Lymphocyte percentage decreased 33.21 10.96 41 134352 2091 34820447
Full blood count abnormal 33.11 10.96 151 134242 18517 34804021
Synovitis 32.77 10.96 7 134386 14059 34808479
Antiviral drug level above therapeutic 32.68 10.96 11 134382 44 34822494
Spinal fracture 32.56 10.96 82 134311 7416 34815122
Graft versus host disease in skin 32.53 10.96 56 134337 3869 34818669
Metabolic acidosis 32.51 10.96 75 134318 43605 34778933
Treatment noncompliance 32.49 10.96 36 134357 28064 34794474
Haemophagocytic lymphohistiocytosis 31.80 10.96 116 134277 12857 34809681
Treatment failure 31.76 10.96 84 134309 46613 34775925
Ventricular fibrillation 31.73 10.96 25 134368 22929 34799609
Therapeutic product effect decreased 31.61 10.96 53 134340 34690 34787848
Fungal infection 31.38 10.96 133 134260 15802 34806736
Intentional product use issue 31.31 10.96 121 134272 59695 34762843
Prostate cancer 31.21 10.96 66 134327 39583 34782955
Chest pain 31.18 10.96 324 134069 126438 34696100
Mantle cell lymphoma 30.97 10.96 32 134361 1340 34821198
Venoocclusive disease 30.75 10.96 46 134347 2821 34819717
Multiple organ dysfunction syndrome 30.51 10.96 438 133955 76128 34746410
Toxoplasmosis 30.26 10.96 31 134362 1285 34821253
Mucormycosis 30.13 10.96 69 134324 5873 34816665
Glycosylated haemoglobin increased 30.12 10.96 4 134389 11356 34811182
Haematochezia 29.94 10.96 86 134307 46448 34776090
Colitis ulcerative 29.90 10.96 13 134380 16507 34806031
Neutrophil percentage increased 29.76 10.96 36 134357 1797 34820741
Incorrect route of product administration 29.66 10.96 10 134383 14835 34807703
Engraftment syndrome 29.54 10.96 27 134366 970 34821568
Bacterial infection 29.51 10.96 137 134256 16926 34805612
Monoclonal immunoglobulin increased 29.48 10.96 14 134379 157 34822381
Oxygen saturation decreased 29.38 10.96 107 134286 53711 34768827
Device malfunction 29.29 10.96 3 134390 10418 34812120
Rectal haemorrhage 29.24 10.96 70 134323 40179 34782359
Monoclonal immunoglobulin present 28.88 10.96 27 134366 999 34821539
Urine abnormality 28.84 10.96 37 134356 1962 34820576
Vomiting 28.62 10.96 729 133664 246892 34575646
Pneumonia viral 28.59 10.96 47 134346 3127 34819411
Aspartate aminotransferase 28.06 10.96 12 134381 103 34822435
Acute kidney injury 27.66 10.96 1435 132958 303553 34518985
Body temperature decreased 27.44 10.96 8 134385 13026 34809512
Crystalluria 27.11 10.96 19 134374 462 34822076
Wheezing 27.01 10.96 76 134317 41326 34781212
Sleep apnoea syndrome 27.01 10.96 23 134370 20298 34802240
Enterococcal infection 26.99 10.96 88 134305 9218 34813320
Pain in extremity 26.93 10.96 334 134059 126179 34696359
Melaena 26.93 10.96 60 134333 35320 34787218
Bacteraemia 26.85 10.96 148 134245 19569 34802969
Loss of consciousness 26.65 10.96 197 134196 82470 34740068
Multiple allergies 26.42 10.96 44 134349 2959 34819579
Pre-engraftment immune reaction 26.38 10.96 11 134382 88 34822450
Hepatic cirrhosis 26.37 10.96 17 134376 17297 34805241
Underdose 26.31 10.96 10 134383 13770 34808768
Peripheral swelling 26.31 10.96 427 133966 76114 34746424
Atrial fibrillation 26.28 10.96 636 133757 121757 34700781
Paranoia 26.16 10.96 7 134386 12061 34810477
Herpes ophthalmic 25.86 10.96 20 134373 568 34821970
Metastases to bone 25.84 10.96 7 134386 11963 34810575
Urine analysis abnormal 25.72 10.96 35 134358 1966 34820572
Neutrophil count abnormal 25.57 10.96 34 134359 1868 34820670
Mobility decreased 25.56 10.96 48 134345 30080 34792458
Immune system disorder 25.49 10.96 59 134334 5056 34817482
Malignant neoplasm progression 25.07 10.96 217 134176 87829 34734709
Cardiac failure congestive 24.71 10.96 203 134190 83067 34739471
Hiccups 24.59 10.96 90 134303 9992 34812546
Chest discomfort 24.44 10.96 117 134276 54413 34768125
Anaphylactic reaction 24.41 10.96 55 134338 32246 34790292
Neuroleptic malignant syndrome 24.20 10.96 20 134373 17914 34804624
Musculoskeletal stiffness 24.06 10.96 95 134298 46585 34775953
Arteriosclerosis coronary artery 23.94 10.96 9 134384 12476 34810062
Oroantral fistula 23.93 10.96 13 134380 197 34822341
Emotional distress 23.93 10.96 14 134379 15012 34807526
Hospitalisation 23.84 10.96 125 134268 56777 34765761
Hypertension 23.78 10.96 375 134018 136068 34686470
Neutropenic infection 23.64 10.96 29 134364 1469 34821069
Pseudomonal sepsis 23.57 10.96 46 134347 3501 34819037
Graft versus host disease in gastrointestinal tract 23.55 10.96 47 134346 3636 34818902
Obesity 23.52 10.96 10 134383 12868 34809670
Injury 23.37 10.96 27 134366 20660 34801878
C-reactive protein abnormal 23.25 10.96 3 134390 8707 34813831
Schizophrenia 23.10 10.96 3 134390 8663 34813875
Oesophageal carcinoma 23.01 10.96 4 134389 9300 34813238
Product quality issue 22.99 10.96 19 134374 17016 34805522
Myoclonic dystonia 22.98 10.96 9 134384 60 34822478
Coma 22.89 10.96 94 134299 45584 34776954
Lower respiratory tract infection fungal 22.88 10.96 19 134374 599 34821939
Tooth deposit 22.78 10.96 10 134383 92 34822446
Red blood cell sedimentation rate increased 22.53 10.96 4 134389 9158 34813380
Device issue 22.51 10.96 5 134388 9772 34812766
Bone marrow transplant 22.48 10.96 24 134369 1044 34821494
Aspergillus infection 22.39 10.96 100 134293 12154 34810384
Squamous cell carcinoma of skin 22.35 10.96 92 134301 10789 34811749
Acute generalised exanthematous pustulosis 22.35 10.96 67 134326 6709 34815829
Varicella zoster virus infection 22.33 10.96 31 134362 1775 34820763
Disturbance in attention 22.31 10.96 41 134352 25904 34796634
Hypogammaglobulinaemia 22.27 10.96 73 134320 7667 34814871
Dystonia 22.21 10.96 7 134386 10838 34811700
Clostridium difficile colitis 22.04 10.96 119 134274 15611 34806927
Specific gravity urine increased 21.94 10.96 11 134382 140 34822398
Lactose intolerance 21.64 10.96 26 134367 1289 34821249
Strongyloidiasis 21.58 10.96 38 134355 2673 34819865
Neutrophil Pelger-Huet anomaly present 21.58 10.96 13 134380 242 34822296
Poisoning 21.53 10.96 10 134383 12216 34810322
Palpitations 21.50 10.96 80 134313 39906 34782632
Plasma cell leukaemia 21.28 10.96 22 134371 922 34821616
Anti-platelet antibody positive 21.26 10.96 13 134380 249 34822289
Anaphylactic shock 21.24 10.96 18 134375 15923 34806615
Muscle rigidity 21.16 10.96 7 134386 10511 34812027
Fear 21.03 10.96 7 134386 10469 34812069
Haemophilus sepsis 21.00 10.96 8 134385 49 34822489
Blood immunoglobulin G decreased 20.84 10.96 27 134366 1446 34821092
Diabetes mellitus inadequate control 20.81 10.96 13 134380 13451 34809087
Monocyte percentage increased 20.80 10.96 22 134371 947 34821591
Salivary hypersecretion 20.77 10.96 4 134389 8640 34813898
Herpes zoster meningitis 20.73 10.96 8 134385 51 34822487
Product use issue 20.68 10.96 150 134243 63066 34759472
Urine leukocyte esterase positive 20.67 10.96 16 134377 455 34822083
Phlebitis infective 20.46 10.96 10 134383 120 34822418
Leukaemia recurrent 20.39 10.96 28 134365 1587 34820951
Type 2 diabetes mellitus 20.28 10.96 19 134374 16013 34806525
Cyanosis 20.18 10.96 12 134381 12752 34809786
Surgery 20.10 10.96 15 134378 14142 34808396
Immunodeficiency common variable 20.06 10.96 11 134382 170 34822368
Diaphragmatic injury 20.03 10.96 10 134383 126 34822412
Obstructive airways disorder 20.03 10.96 18 134375 15476 34807062
Pneumonia respiratory syncytial viral 19.89 10.96 21 134372 902 34821636
Diabetic ketoacidosis 19.87 10.96 24 134369 18008 34804530
Miosis 19.80 10.96 6 134387 9529 34813009
Streptococcal bacteraemia 19.74 10.96 31 134362 1984 34820554
Congenital herpes simplex infection 19.71 10.96 7 134386 34 34822504
Cytomegalovirus chorioretinitis 19.68 10.96 43 134350 3546 34818992
Blood potassium decreased 19.60 10.96 127 134266 17788 34804750
Pancreatitis 19.51 10.96 80 134313 38811 34783727
Polyomavirus viraemia 19.48 10.96 21 134372 924 34821614
Myalgia 19.45 10.96 218 134175 83892 34738646
Angina pectoris 19.42 10.96 59 134334 31304 34791234
Staphylococcal bacteraemia 19.40 10.96 74 134319 8378 34814160
Blood test abnormal 19.39 10.96 65 134328 6906 34815632
Sleep disorder 19.35 10.96 60 134333 31628 34790910
Toxic epidermal necrolysis 19.31 10.96 146 134247 21500 34801038
Withdrawal syndrome 19.28 10.96 12 134381 12443 34810095
Blood glucose increased 19.18 10.96 164 134229 66554 34755984
Off label use 19.17 10.96 1372 133021 418152 34404386
Fibrin D dimer increased 19.05 10.96 47 134346 4197 34818341
Antineutrophil cytoplasmic antibody positive 19.00 10.96 19 134374 765 34821773
Psychotic disorder 19.00 10.96 41 134352 24411 34798127
Medication error 18.93 10.96 44 134349 25521 34797017
Accessory spleen 18.92 10.96 10 134383 143 34822395
Accidental exposure to product 18.92 10.96 13 134380 12789 34809749
Duodenal ulcer 18.91 10.96 8 134385 10324 34812214
Respiratory syncytial virus infection 18.90 10.96 50 134343 4659 34817879
Knee arthroplasty 18.86 10.96 3 134390 7441 34815097
Blood lactate dehydrogenase increased 18.81 10.96 152 134241 22838 34799700
Injection site haemorrhage 18.80 10.96 7 134386 9761 34812777
Encephalitis autoimmune 18.79 10.96 18 134375 687 34821851
Bronchiolitis obliterans syndrome 18.74 10.96 11 134382 195 34822343
Ventricular tachycardia 18.69 10.96 47 134346 26532 34796006
Atrial septal defect 18.68 10.96 3 134390 7389 34815149
Bladder cancer 18.66 10.96 21 134372 16257 34806281
Pneumonia influenzal 18.55 10.96 26 134367 1502 34821036
Stevens-Johnson syndrome 18.51 10.96 129 134264 18510 34804028
Back disorder 18.49 10.96 62 134331 6589 34815949
Bacterial sepsis 18.36 10.96 53 134340 5197 34817341
Enterococcal bacteraemia 18.33 10.96 29 134364 1868 34820670
Coronary artery stenosis 18.32 10.96 7 134386 9609 34812929
Nightmare 18.27 10.96 17 134376 14374 34808164
Product prescribing error 18.18 10.96 38 134355 22889 34799649
Product substitution issue 18.18 10.96 8 134385 10087 34812451
Dry eye 18.15 10.96 79 134314 9496 34813042
Depressed mood 18.00 10.96 29 134364 19288 34803250
Mania 18.00 10.96 7 134386 9504 34813034
Bone lesion 17.98 10.96 37 134356 2926 34819612
Hyperhidrosis 17.97 10.96 195 134198 75497 34747041
Fungaemia 17.92 10.96 34 134359 2534 34820004
Herpes simplex viraemia 17.91 10.96 8 134385 77 34822461
Corneal deposits 17.88 10.96 11 134382 213 34822325
Candida infection 17.83 10.96 123 134270 17592 34804946
Headache 17.82 10.96 612 133781 200023 34622515
Immunodeficiency 17.79 10.96 54 134339 5444 34817094
NPM1 gene mutation 17.78 10.96 9 134384 117 34822421
Haematopoietic stem cell mobilisation 17.77 10.96 10 134383 163 34822375
Sinusitis 17.75 10.96 240 134153 41162 34781376
Pulmonary fibrosis 17.73 10.96 27 134366 18369 34804169
Febrile infection 17.61 10.96 31 134362 2180 34820358
Mucosal disorder 17.53 10.96 27 134366 1699 34820839
Metastases to liver 17.51 10.96 16 134377 13647 34808891
Hordeolum 17.48 10.96 21 134372 1041 34821497
Erectile dysfunction 17.40 10.96 33 134360 20604 34801934
Blood phosphorus decreased 17.31 10.96 38 134355 3143 34819395
Autoimmune haemolytic anaemia 17.30 10.96 47 134346 4449 34818089
Fibrous histiocytoma 17.30 10.96 10 134383 172 34822366
Pallor 17.20 10.96 46 134347 25434 34797104
Poikiloderma 17.20 10.96 10 134383 174 34822364
Light chain disease 17.13 10.96 9 134384 127 34822411
Product dose omission issue 17.10 10.96 591 133802 119120 34703418
Impaired work ability 17.09 10.96 3 134390 6927 34815611
Product storage error 17.07 10.96 5 134388 8117 34814421
Bone pain 17.05 10.96 137 134256 20549 34801989
Escherichia sepsis 16.94 10.96 48 134345 4656 34817882
Epstein-Barr viraemia 16.94 10.96 23 134370 1289 34821249
Hepatic encephalopathy 16.77 10.96 19 134374 14666 34807872
Enterococcal sepsis 16.76 10.96 26 134367 1646 34820892
Malaise 16.69 10.96 566 133827 185259 34637279
Nasopharyngitis 16.68 10.96 369 134024 69599 34752939
Injection site swelling 16.64 10.96 12 134381 11515 34811023
Oral herpes 16.58 10.96 53 134340 5494 34817044
Dyspnoea exertional 16.53 10.96 98 134295 43181 34779357
Congenital pneumonia 16.52 10.96 8 134385 94 34822444
Splenic embolism 16.47 10.96 10 134383 189 34822349
Herpes zoster meningoencephalitis 16.46 10.96 12 134381 311 34822227
Sideroblastic anaemia 16.42 10.96 11 134382 248 34822290
Hypouricaemia 16.31 10.96 11 134382 251 34822287
Therapy cessation 16.27 10.96 25 134368 16948 34805590
Heart rate decreased 16.11 10.96 65 134328 31680 34790858
Achromobacter infection 16.08 10.96 7 134386 63 34822475
Injection site mass 16.06 10.96 3 134390 6623 34815915
Stenotrophomonas infection 16.06 10.96 29 134364 2081 34820457
Upper respiratory tract infection 16.02 10.96 196 134197 32863 34789675
Platelet count abnormal 16.01 10.96 35 134358 2887 34819651
Postural tremor 15.88 10.96 12 134381 329 34822209
Light chain analysis decreased 15.85 10.96 6 134387 36 34822502
Metastases to lung 15.84 10.96 8 134385 9312 34813226
Angina unstable 15.72 10.96 13 134380 11640 34810898
Reticulocytosis 15.64 10.96 11 134382 269 34822269
Renal failure 15.62 10.96 632 133761 129925 34692613
Loss of personal independence in daily activities 15.57 10.96 70 134323 33109 34789429
Ischaemic stroke 15.55 10.96 29 134364 18221 34804317
Protein total abnormal 15.51 10.96 12 134381 341 34822197
Gynaecomastia 15.50 10.96 10 134383 10170 34812368
Neuromyotonia 15.45 10.96 6 134387 39 34822499
CNS ventriculitis 15.36 10.96 11 134382 277 34822261
CSF cell count increased 15.20 10.96 6 134387 41 34822497
Follicular mucinosis 15.06 10.96 5 134388 19 34822519
Pain 14.94 10.96 639 133754 204036 34618502
Osteoarthritis 14.91 10.96 36 134357 20606 34801932
Therapeutic response decreased 14.89 10.96 60 134333 29253 34793285
Neuralgic amyotrophy 14.87 10.96 10 134383 227 34822311
Pulmonary embolism 14.87 10.96 451 133942 89295 34733243
Cytomegalovirus colitis 14.86 10.96 33 134360 2751 34819787
Flushing 14.85 10.96 69 134324 32351 34790187
Hyperpyrexia 14.83 10.96 33 134360 2755 34819783
Cataract 14.81 10.96 160 134233 26026 34796512
Meningitis aseptic 14.78 10.96 36 134357 3188 34819350
Gastric disorder 14.73 10.96 90 134303 12351 34810187
Prostatic specific antigen increased 14.68 10.96 21 134372 14659 34807879
Viral infection 14.68 10.96 117 134276 17506 34805032
Musculoskeletal pain 14.66 10.96 68 134325 31895 34790643
Middle insomnia 14.64 10.96 4 134389 6798 34815740
Chimerism 14.64 10.96 10 134383 233 34822305
Pancreatic carcinoma 14.60 10.96 8 134385 8893 34813645
Haematoma 14.58 10.96 50 134343 25555 34796983
White blood cell count abnormal 14.57 10.96 36 134357 3217 34819321
Meningitis cryptococcal 14.57 10.96 30 134363 2374 34820164
Vitamin B12 decreased 14.48 10.96 21 134372 1252 34821286
Haematuria 14.42 10.96 123 134270 49943 34772595
Gastrooesophageal reflux disease 14.42 10.96 86 134307 37838 34784700
Haemolytic uraemic syndrome 14.41 10.96 29 134364 2257 34820281
Escherichia bacteraemia 14.38 10.96 36 134357 3244 34819294
Pneumocystis jirovecii pneumonia 14.37 10.96 127 134266 19583 34802955
Arthritis 14.19 10.96 67 134326 31279 34791259
Weight increased 14.15 10.96 262 134131 92771 34729767
Hyponatraemia 14.15 10.96 228 134165 82463 34740075
Blood immunoglobulin A increased 14.12 10.96 11 134382 316 34822222
Tumour flare 14.10 10.96 17 134376 846 34821692
Pathological fracture 14.09 10.96 43 134350 4348 34818190
Liver function test 14.08 10.96 6 134387 51 34822487
Cerebral infarction 14.07 10.96 56 134337 27399 34795139
Metastases to central nervous system 14.01 10.96 7 134386 8198 34814340
Blood loss anaemia 13.98 10.96 7 134386 8187 34814351
Rash maculo-papular 13.92 10.96 169 134224 28282 34794256
Lymphopenia 13.91 10.96 109 134284 16226 34806312
Chills 13.89 10.96 409 133984 80634 34741904
Aspergillus test positive 13.88 10.96 13 134380 482 34822056
Gastroenteritis adenovirus 13.87 10.96 8 134385 137 34822401
Retinitis viral 13.83 10.96 7 134386 91 34822447
Campylobacter gastroenteritis 13.81 10.96 17 134376 864 34821674
Road traffic accident 13.77 10.96 29 134364 17421 34805117
Blood pressure decreased 13.77 10.96 129 134264 51386 34771152
Herpes simplex encephalitis 13.74 10.96 11 134382 329 34822209
Chronic obstructive pulmonary disease 13.72 10.96 121 134272 48797 34773741
Epstein-Barr virus associated lymphoproliferative disorder 13.70 10.96 26 134367 1938 34820600
CSF lactate increased 13.70 10.96 3 134390 0 34822538
Idiopathic pneumonia syndrome 13.69 10.96 10 134383 260 34822278
Encephalomyelitis 13.69 10.96 6 134387 55 34822483
Cardiomegaly 13.63 10.96 24 134369 15414 34807124
Swollen tongue 13.54 10.96 22 134371 14583 34807955
Pulpitis dental 13.51 10.96 14 134379 588 34821950
Amyloidosis 13.47 10.96 27 134366 2096 34820442
Oesophagopleural fistula 13.41 10.96 6 134387 58 34822480
Dyslipidaemia 13.38 10.96 6 134387 7482 34815056
Neurological examination abnormal 13.37 10.96 10 134383 270 34822268
Myasthenia gravis 13.31 10.96 5 134388 6935 34815603
Ischaemic cardiomyopathy 13.31 10.96 4 134389 6385 34816153
Pulmonary hypertension 13.21 10.96 39 134354 20885 34801653
Gait disturbance 13.19 10.96 239 134154 84901 34737637
Weight decreased 13.16 10.96 549 133844 175752 34646786
Adenomatous polyposis coli 13.14 10.96 8 134385 152 34822386
Accidental overdose 13.11 10.96 37 134356 20103 34802435
Klebsiella bacteraemia 13.11 10.96 21 134372 1367 34821171
CSF protein increased 13.05 10.96 16 134377 810 34821728
Acute lymphocytic leukaemia 13.02 10.96 33 134360 2996 34819542
Herpes simplex meningoencephalitis 13.02 10.96 4 134389 11 34822527
Band neutrophil percentage increased 13.01 10.96 7 134386 104 34822434
Asphyxia 12.98 10.96 5 134388 6830 34815708
Marrow hyperplasia 12.96 10.96 19 134374 1144 34821394
Bacterial test 12.96 10.96 8 134385 156 34822382
Discomfort 12.92 10.96 34 134359 18904 34803634
Embolism 12.91 10.96 62 134331 7767 34814771
Neutrophil percentage decreased 12.90 10.96 11 134382 360 34822178
Myocardial ischaemia 12.86 10.96 30 134363 17378 34805160
Cerebrovascular accident 12.85 10.96 239 134154 84572 34737966
Lung neoplasm malignant 12.83 10.96 30 134363 17365 34805173
White blood cells urine positive 12.83 10.96 20 134373 1272 34821266
Agitation 12.78 10.96 150 134243 57249 34765289
Hypoaesthesia 12.78 10.96 318 134075 61126 34761412
Macular fibrosis 12.77 10.96 11 134382 365 34822173
Viral haemorrhagic cystitis 12.75 10.96 19 134374 1161 34821377
Red blood cells urine positive 12.68 10.96 24 134369 1785 34820753
Haematemesis 12.68 10.96 59 134334 27652 34794886
Eosinophil percentage increased 12.61 10.96 13 134380 543 34821995
Myelodysplastic syndrome 12.61 10.96 121 134272 19087 34803451
Dermatitis exfoliative generalised 12.55 10.96 37 134356 3670 34818868
Transplant failure 12.55 10.96 36 134357 3517 34819021
Systemic mycosis 12.46 10.96 22 134371 1551 34820987
Systemic candida 12.44 10.96 37 134356 3689 34818849
Acinetobacter infection 12.42 10.96 19 134374 1188 34821350
Incorrect dose administered 12.37 10.96 98 134295 40417 34782121
Mastitis 12.31 10.96 8 134385 171 34822367
Neutrophil morphology abnormal 12.28 10.96 6 134387 72 34822466
Platelet disorder 12.27 10.96 23 134370 1698 34820840
Peritonitis 12.25 10.96 28 134365 16337 34806201
Epstein-Barr virus infection reactivation 12.25 10.96 18 134375 1086 34821452
Eczema herpeticum 12.23 10.96 8 134385 173 34822365
JC virus CSF test positive 12.23 10.96 7 134386 118 34822420
Proteus infection 12.23 10.96 18 134375 1088 34821450
Atrial flutter 12.22 10.96 102 134291 15472 34807066
Hypomagnesaemia 12.22 10.96 43 134350 21808 34800730
Product administration error 12.21 10.96 28 134365 16316 34806222
Varicella virus test positive 12.20 10.96 6 134387 73 34822465
Gastric fistula 12.13 10.96 6 134387 74 34822464
Asterixis 12.12 10.96 19 134374 1214 34821324
Hip fracture 12.12 10.96 83 134310 11842 34810696
Hepatosplenomegaly neonatal 12.10 10.96 5 134388 39 34822499
Pneumonia pneumococcal 12.10 10.96 26 134367 2120 34820418
Device occlusion 12.08 10.96 5 134388 6540 34815998
Cardiac failure 12.07 10.96 263 134130 90985 34731553
Injection site erythema 12.07 10.96 27 134366 15872 34806666
Cataract subcapsular 12.04 10.96 11 134382 395 34822143
Drug intolerance 12.02 10.96 159 134234 59411 34763127
Oral lichenoid reaction 11.99 10.96 5 134388 40 34822498
Haemoptysis 11.97 10.96 82 134311 34924 34787614
Immunosuppression 11.94 10.96 52 134341 6252 34816286
Dermatitis allergic 11.93 10.96 55 134338 6775 34815763
Obliterative bronchiolitis 11.89 10.96 19 134374 1234 34821304
Anger 11.89 10.96 17 134376 11867 34810671
pH urine increased 11.86 10.96 6 134387 78 34822460
Clonal haematopoiesis 11.86 10.96 6 134387 78 34822460
Atrioventricular block complete 11.84 10.96 11 134382 9308 34813230
Renal tubular disorder 11.79 10.96 42 134351 4601 34817937
Cytomegalovirus oesophagitis 11.78 10.96 12 134381 494 34822044
Acanthamoeba infection 11.74 10.96 11 134382 408 34822130
Vitamin B1 decreased 11.71 10.96 10 134383 328 34822210
Rash vesicular 11.67 10.96 30 134363 2747 34819791
Joint swelling 11.67 10.96 161 134232 59729 34762809
Listeriosis 11.63 10.96 17 134376 1021 34821517
Selective IgG subclass deficiency 11.63 10.96 3 134390 3 34822535
Blood triglycerides increased 11.62 10.96 23 134370 14136 34808402
Hyperlipidaemia 11.59 10.96 24 134369 14505 34808033
Graft versus host disease in liver 11.55 10.96 19 134374 1265 34821273
Granulomatous liver disease 11.49 10.96 13 134380 604 34821934
Haemorrhagic cyst 11.46 10.96 6 134387 84 34822454
Thyroxine increased 11.46 10.96 6 134387 84 34822454
Therapy interrupted 11.46 10.96 22 134371 13675 34808863
Sputum discoloured 11.45 10.96 8 134385 7804 34814734
Chronic lymphocytic leukaemia transformation 11.44 10.96 8 134385 194 34822344
Joint stiffness 11.43 10.96 15 134378 10858 34811680
Glomerulosclerosis 11.37 10.96 15 134378 818 34821720
Injection site bruising 11.28 10.96 10 134383 8653 34813885
Central nervous system lesion 11.25 10.96 52 134341 6411 34816127
Pyogenic granuloma 11.22 10.96 9 134384 270 34822268
Alveolitis necrotising 11.17 10.96 4 134389 20 34822518
Emotional disorder 11.16 10.96 4 134389 5712 34816826
Pancreatitis acute 11.13 10.96 63 134330 28078 34794460
Auditory disorder 11.10 10.96 9 134384 274 34822264
Basal cell carcinoma 11.07 10.96 120 134273 19538 34803000
West Nile viral infection 11.05 10.96 14 134379 733 34821805
Rhinovirus infection 11.01 10.96 39 134354 4260 34818278
Central venous pressure increased 11.01 10.96 4 134389 21 34822517
Lumbar puncture abnormal 11.01 10.96 4 134389 21 34822517
Meningoencephalitis bacterial 11.01 10.96 7 134386 144 34822394
Dermatitis acneiform 11.00 10.96 5 134388 6184 34816354

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 2168.06 10.17 1521 221207 51738 79469922
Febrile neutropenia 1281.36 10.17 2305 220423 228694 79292966
White blood cell count decreased 920.97 10.17 1781 220947 186507 79335153
Platelet count decreased 871.03 10.17 1774 220954 192890 79328770
Pneumonia 776.23 10.17 3767 218961 656479 78865181
Cytokine release syndrome 744.20 10.17 692 222036 35306 79486354
Neutropenia 744.09 10.17 2120 220608 285590 79236070
Neutrophil count decreased 614.89 10.17 1010 221718 92949 79428711
Pyrexia 607.94 10.17 3595 219133 675114 78846546
Neurotoxicity 549.97 10.17 560 222168 31958 79489702
Lymphocyte count decreased 547.48 10.17 668 222060 46621 79475039
Completed suicide 506.37 10.17 50 222678 245717 79275943
Thrombocytopenia 492.19 10.17 1744 220984 263515 79258145
Neuropathy peripheral 468.36 10.17 1143 221585 140162 79381498
Rheumatoid arthritis 438.49 10.17 39 222689 208431 79313229
Cytomegalovirus infection 407.91 10.17 548 222180 42096 79479564
Urine abnormality 406.32 10.17 265 222463 7954 79513706
Synovitis 394.23 10.17 5 222723 150729 79370931
Full blood count decreased 386.18 10.17 424 222304 26395 79495265
Graft versus host disease 360.06 10.17 314 222414 14712 79506948
Drug abuse 354.43 10.17 26 222702 162665 79358995
Contraindicated product administered 352.49 10.17 22 222706 157516 79364144
Pancytopenia 347.73 10.17 1136 221592 164609 79357051
Toxicity to various agents 330.94 10.17 415 222313 421125 79100535
Sepsis 328.33 10.17 1556 221172 267872 79253788
Arthralgia 328.17 10.17 692 222036 571111 78950549
Drug intolerance 307.33 10.17 178 222550 263941 79257719
Joint swelling 294.81 10.17 225 222503 288421 79233239
Therapeutic product effect decreased 276.12 10.17 60 222668 163803 79357857
Urine leukocyte esterase positive 265.87 10.17 157 222571 3934 79517726
Systemic lupus erythematosus 253.76 10.17 23 222705 121126 79400534
Pemphigus 249.28 10.17 6 222722 99576 79422084
Pain 238.29 10.17 1084 221644 702718 78818942
Urinary sediment present 238.12 10.17 124 222604 2411 79519249
Crystal urine present 235.96 10.17 117 222611 2043 79519617
Acute graft versus host disease 234.65 10.17 208 222520 9959 79511701
Drug hypersensitivity 228.47 10.17 300 222428 298616 79223044
White blood cells urine positive 227.33 10.17 165 222563 5910 79515750
Red blood cells urine positive 211.65 10.17 146 222582 4817 79516843
Lymphocyte percentage decreased 211.31 10.17 146 222582 4830 79516830
Thrombosis 211.19 10.17 614 222114 83486 79438174
Arthropathy 205.02 10.17 120 222608 176991 79344669
Neutrophil percentage increased 197.76 10.17 137 222591 4552 79517108
Urine analysis abnormal 197.32 10.17 156 222572 6364 79515296
Intentional overdose 195.16 10.17 31 222697 105929 79415731
Pathogen resistance 194.86 10.17 220 222508 14122 79507538
Acute kidney injury 193.18 10.17 2258 220470 517146 79004514
Epstein-Barr virus infection 192.24 10.17 219 222509 14197 79507463
Treatment failure 191.06 10.17 120 222608 170366 79351294
Meningoencephalitis herpetic 188.86 10.17 98 222630 1891 79519769
Discomfort 188.65 10.17 58 222670 125559 79396101
Cytomegalovirus viraemia 188.56 10.17 205 222523 12616 79509044
Encephalitis viral 183.57 10.17 105 222623 2474 79519186
Alopecia 182.10 10.17 227 222501 231128 79290532
Glossodynia 179.93 10.17 35 222693 103302 79418358
Wound 179.29 10.17 51 222677 116128 79405532
Bronchopulmonary aspergillosis 178.27 10.17 263 222465 22031 79499629
Post transplant lymphoproliferative disorder 171.57 10.17 185 222543 11279 79510381
Duodenal ulcer perforation 169.64 10.17 3 222725 66208 79455452
Drug ineffective 168.36 10.17 2074 220654 1078839 78442821
Multiple organ dysfunction syndrome 167.54 10.17 723 222005 119523 79402137
Maternal exposure during pregnancy 167.46 10.17 86 222642 136452 79385208
Injection site pain 166.50 10.17 77 222651 129761 79391899
Deep vein thrombosis 164.62 10.17 722 222006 120197 79401463
Mucosal inflammation 162.82 10.17 523 222205 75057 79446603
Herpes simplex 160.58 10.17 184 222544 12003 79509657
Helicobacter infection 158.10 10.17 9 222719 69695 79451965
Psoriatic arthropathy 157.58 10.17 17 222711 77982 79443678
Intentional product misuse 154.00 10.17 38 222690 95127 79426533
Drug resistance 152.13 10.17 353 222375 41860 79479800
Immune effector cell-associated neurotoxicity syndrome 149.83 10.17 127 222601 5721 79515939
Acute myeloid leukaemia 149.19 10.17 291 222437 30594 79491066
Condition aggravated 149.07 10.17 807 221921 500317 79021343
Blood urine present 148.79 10.17 236 222492 21061 79500599
Tumour lysis syndrome 147.97 10.17 251 222477 23688 79497972
Sensitisation 144.97 10.17 99 222629 3212 79518448
Encephalopathy 144.83 10.17 466 222262 66931 79454729
Acute graft versus host disease in skin 144.45 10.17 140 222588 7518 79514142
Encephalitis 143.12 10.17 191 222537 14569 79507091
Septic shock 141.93 10.17 699 222029 122102 79399558
Swelling 141.72 10.17 242 222486 216469 79305191
Drug interaction 140.42 10.17 639 222089 414544 79107116
Rash 138.17 10.17 2325 220403 576033 78945627
Hypersensitivity 136.53 10.17 334 222394 261905 79259755
Pericarditis 136.49 10.17 60 222668 104176 79417484
Inappropriate schedule of product administration 135.22 10.17 105 222623 133523 79388137
Neutropenic sepsis 134.39 10.17 258 222470 26806 79494854
Bacterial test 132.87 10.17 66 222662 1157 79520503
Acute graft versus host disease in intestine 131.65 10.17 101 222627 3940 79517720
Polycystic ovaries 130.95 10.17 98 222630 3681 79517979
Cytomegalovirus infection reactivation 127.54 10.17 139 222589 8577 79513083
Cytopenia 126.35 10.17 214 222514 20169 79501491
Diarrhoea 123.93 10.17 3275 219453 877214 78644446
Musculoskeletal stiffness 120.41 10.17 189 222539 174819 79346841
Overdose 120.15 10.17 206 222522 184000 79337660
Bacterial test positive 119.97 10.17 125 222603 7324 79514336
Haematotoxicity 118.24 10.17 179 222549 15340 79506320
Urine ketone body present 115.91 10.17 89 222639 3476 79518184
Nephropathy toxic 115.64 10.17 206 222522 20213 79501447
Laboratory test abnormal 115.04 10.17 247 222481 27801 79493859
Chronic graft versus host disease 113.19 10.17 116 222612 6665 79514995
Suicide attempt 112.98 10.17 45 222683 82887 79438773
Plasma cell myeloma recurrent 112.80 10.17 101 222627 4900 79516760
Cystitis haemorrhagic 111.70 10.17 133 222595 9039 79512621
Pre-engraftment immune reaction 110.46 10.17 40 222688 301 79521359
Abdominal discomfort 109.92 10.17 347 222381 250380 79271280
Impaired healing 107.78 10.17 55 222673 87600 79434060
C-reactive protein abnormal 107.41 10.17 7 222721 48360 79473300
Ejection fraction 106.90 10.17 71 222657 2198 79519462
Acute myeloid leukaemia recurrent 106.82 10.17 83 222645 3300 79518360
Crystalluria 105.33 10.17 52 222676 899 79520761
Constipation 105.13 10.17 1231 221497 281819 79239841
COVID-19 pneumonia 104.77 10.17 242 222486 28607 79493053
Haemophagocytic lymphohistiocytosis 104.56 10.17 205 222523 21632 79500028
Arthritis 103.23 10.17 101 222627 114779 79406881
Pneumonia fungal 102.52 10.17 141 222587 11069 79510591
Weight increased 100.97 10.17 415 222313 276971 79244689
Culture urine positive 100.89 10.17 90 222638 4345 79517315
Red blood cell count decreased 96.96 10.17 367 222361 57146 79464514
Monocyte percentage increased 96.08 10.17 65 222663 2076 79519584
Mobility decreased 95.94 10.17 120 222608 122055 79399605
Chronic lymphocytic leukaemia 95.64 10.17 91 222637 4775 79516885
Psoriasis 95.01 10.17 67 222661 89520 79432140
Hypoglycaemia 92.81 10.17 88 222640 101506 79420154
Pain in extremity 92.48 10.17 617 222111 363921 79157739
Muscle injury 92.18 10.17 13 222715 48548 79473112
Lymphopenia 91.48 10.17 238 222490 30319 79491341
Knee arthroplasty 91.10 10.17 8 222720 43240 79478420
Adenovirus infection 90.77 10.17 115 222613 8332 79513328
Haemoglobin urine present 90.52 10.17 47 222681 908 79520752
Blood pressure systolic increased 90.18 10.17 37 222691 66949 79454711
Stem cell transplant 89.93 10.17 78 222650 3626 79518034
Human herpesvirus 6 infection 89.89 10.17 92 222636 5278 79516382
Irritable bowel syndrome 89.44 10.17 31 222697 62210 79459450
Type 2 diabetes mellitus 88.25 10.17 25 222703 57097 79464563
Wrong technique in product usage process 86.94 10.17 49 222679 73826 79447834
Red blood cell sedimentation rate increased 85.58 10.17 13 222715 45929 79475731
Cytomegalovirus test positive 85.55 10.17 94 222634 5853 79515807
Product use issue 85.34 10.17 300 222428 209522 79312138
Aspergillus infection 83.53 10.17 173 222555 18988 79502672
Blood pressure fluctuation 82.74 10.17 42 222686 67103 79454557
Toxoplasmosis 82.62 10.17 65 222663 2632 79519028
Herpes zoster 82.57 10.17 493 222235 92590 79429070
Venoocclusive liver disease 81.62 10.17 130 222598 11641 79510019
Toxic encephalopathy 80.23 10.17 127 222601 11313 79510347
Specific gravity urine decreased 79.76 10.17 42 222686 836 79520824
Renal disorder 79.69 10.17 279 222449 41826 79479834
Sedation 79.64 10.17 23 222705 51872 79469788
Light chain analysis increased 79.11 10.17 53 222675 1665 79519995
Enterococcal infection 78.62 10.17 150 222578 15510 79506150
Infusion related reaction 78.53 10.17 353 222375 229884 79291776
Diffuse large B-cell lymphoma 77.23 10.17 129 222599 12020 79509640
Suicidal ideation 77.19 10.17 60 222668 76280 79445380
Respiratory failure 76.33 10.17 807 221921 180104 79341556
Smooth muscle cell neoplasm 76.16 10.17 42 222686 920 79520740
Blood pressure increased 75.16 10.17 319 222409 211041 79310619
Red cell distribution width increased 74.08 10.17 144 222584 15098 79506562
Pneumonia cytomegaloviral 74.02 10.17 80 222648 4889 79516771
Respiratory syncytial virus infection 73.84 10.17 110 222618 9292 79512368
Mucormycosis 73.68 10.17 104 222624 8365 79513295
Injury 73.31 10.17 65 222663 77431 79444229
Bacteraemia 73.27 10.17 230 222498 32594 79489066
Hepatic enzyme increased 72.98 10.17 263 222465 182347 79339313
Nitrite urine present 72.34 10.17 44 222684 1165 79520495
Antiviral drug level above therapeutic 71.92 10.17 20 222708 53 79521607
Blood test abnormal 71.53 10.17 155 222573 17555 79504105
Blood creatinine increased 71.29 10.17 704 222024 154353 79367307
International normalised ratio increased 69.93 10.17 80 222648 84641 79437019
Herpes virus infection 69.54 10.17 92 222636 6957 79514703
Folliculitis 69.20 10.17 34 222694 55346 79466314
Haemoglobin decreased 68.74 10.17 934 221794 221185 79300475
Influenza 68.37 10.17 606 222122 129000 79392660
Intentional self-injury 68.28 10.17 6 222722 32413 79489247
Blood cholesterol increased 67.01 10.17 81 222647 83639 79438021
Hip arthroplasty 66.87 10.17 10 222718 35746 79485914
Thrombotic microangiopathy 66.54 10.17 163 222565 20006 79501654
Drug dependence 66.49 10.17 16 222712 40753 79480907
Osteoarthritis 66.22 10.17 88 222640 87221 79434439
Engraftment syndrome 66.16 10.17 44 222684 1365 79520295
Plasmacytoma 65.79 10.17 71 222657 4332 79517328
Graft versus host disease in skin 65.76 10.17 83 222645 5990 79515670
Obesity 65.29 10.17 10 222718 35115 79486545
Injection site reaction 64.95 10.17 36 222692 54749 79466911
Sopor 64.66 10.17 8 222720 33002 79488658
Musculoskeletal pain 64.42 10.17 117 222611 102237 79419423
Rhabdomyolysis 63.92 10.17 119 222609 103012 79418648
Varicella zoster virus infection 63.55 10.17 70 222658 4371 79517289
Intentional product use issue 63.51 10.17 215 222513 151897 79369763
Malaise 62.53 10.17 977 221751 488892 79032768
Specific gravity urine increased 62.31 10.17 29 222699 437 79521223
Blood bilirubin increased 62.11 10.17 356 222372 65876 79455784
Sleep disorder due to general medical condition, insomnia type 62.05 10.17 22 222706 43534 79478126
Atrial fibrillation 61.59 10.17 833 221895 197053 79324607
Encephalitis cytomegalovirus 61.59 10.17 39 222689 1111 79520549
Injection site bruising 61.41 10.17 19 222709 40983 79480677
Graft versus host disease in gastrointestinal tract 61.24 10.17 82 222646 6274 79515386
Ophthalmic herpes simplex 60.92 10.17 33 222695 697 79520963
Myocardial infarction 60.58 10.17 286 222442 183843 79337817
Injection site swelling 60.33 10.17 28 222700 47104 79474556
Injection site erythema 60.14 10.17 78 222650 78119 79443541
Hyperbilirubinaemia 59.59 10.17 177 222551 24341 79497319
Clostridium difficile colitis 59.44 10.17 212 222516 32071 79489589
Pleocytosis 58.25 10.17 41 222687 1398 79520262
Depression 57.93 10.17 361 222367 216429 79305231
Hypogammaglobulinaemia 57.71 10.17 118 222610 12833 79508827
Acute lymphocytic leukaemia recurrent 56.70 10.17 68 222660 4656 79517004
General physical health deterioration 56.01 10.17 495 222233 274743 79246917
Rash maculo-papular 55.61 10.17 306 222422 55772 79465888
Organic brain syndrome 55.20 10.17 27 222701 457 79521203
Dyspnoea 54.68 10.17 1903 220825 855122 78666538
Aplastic anaemia 53.12 10.17 139 222589 17766 79503894
Renal failure 53.03 10.17 822 221906 200146 79321514
Weight decreased 52.84 10.17 687 222041 354511 79167149
Exposure during pregnancy 51.63 10.17 130 222598 101002 79420658
Necrotising retinitis 51.62 10.17 36 222692 1209 79520451
Inflammation 51.46 10.17 116 222612 93637 79428023
Bacterial sepsis 50.71 10.17 86 222642 8112 79513548
Ejection fraction abnormal 50.58 10.17 47 222681 2393 79519267
Ill-defined disorder 50.36 10.17 66 222662 65809 79455851
Nephrectomy 50.26 10.17 44 222684 2071 79519589
Rhinitis allergic 50.26 10.17 108 222620 12161 79509499
Therapeutic product effect incomplete 50.20 10.17 214 222514 141431 79380229
COVID-19 49.98 10.17 666 222062 157008 79364652
Blood lactate dehydrogenase increased 49.59 10.17 229 222499 38941 79482719
Acute graft versus host disease in liver 49.53 10.17 42 222686 1893 79519767
Incorrect route of product administration 49.15 10.17 18 222710 34911 79486749
Anaemia 49.06 10.17 1607 221121 443408 79078252
Oxygen saturation decreased 48.84 10.17 190 222538 128857 79392803
Venoocclusive disease 48.73 10.17 62 222666 4511 79517149
Cardio-respiratory arrest 48.33 10.17 149 222579 108361 79413299
Band sensation 47.98 10.17 29 222699 759 79520901
Escherichia bacteraemia 47.61 10.17 74 222654 6488 79515172
Anaphylactic reaction 47.29 10.17 102 222626 83641 79438019
Encephalitis autoimmune 47.19 10.17 44 222684 2250 79519410
Foot deformity 46.75 10.17 6 222722 24068 79497592
Lactic acidosis 46.47 10.17 78 222650 70281 79451379
Medication error 45.43 10.17 76 222652 68566 79453094
Engraft failure 45.38 10.17 27 222701 686 79520974
Parainfluenzae virus infection 45.37 10.17 67 222661 5615 79516045
Fusarium infection 45.33 10.17 39 222689 1793 79519867
Underdose 45.12 10.17 18 222710 33133 79488527
Thyroxine free increased 45.05 10.17 33 222695 1199 79520461
CSF protein increased 44.86 10.17 33 222695 1207 79520453
Chills 44.82 10.17 662 222066 159572 79362088
Labelled drug-drug interaction medication error 44.80 10.17 11 222717 27639 79494021
Bursitis 44.79 10.17 22 222706 35822 79485838
Acute generalised exanthematous pustulosis 44.27 10.17 127 222601 17127 79504533
Pulmonary fibrosis 44.18 10.17 35 222693 44077 79477583
Anxiety 44.16 10.17 462 222266 248050 79273610
Blood thyroid stimulating hormone decreased 43.64 10.17 66 222662 5650 79516010
Body temperature decreased 42.87 10.17 18 222710 32127 79489533
Factor XIII deficiency 42.38 10.17 14 222714 77 79521583
Muscle spasms 42.08 10.17 704 222024 174026 79347634
Death 41.98 10.17 1959 220769 564555 78957105
Systemic mycosis 41.62 10.17 44 222684 2622 79519038
Drug withdrawal syndrome 40.89 10.17 23 222705 34695 79486965
Bacterial infection 40.44 10.17 184 222544 31096 79490564
Taste disorder 40.15 10.17 116 222612 15707 79505953
Osteoporosis 39.56 10.17 56 222672 54056 79467604
Staphylococcal bacteraemia 39.52 10.17 98 222630 12120 79509540
Neuroleptic malignant syndrome 39.12 10.17 14 222714 27545 79494115
Antineutrophil cytoplasmic antibody positive 38.99 10.17 31 222697 1275 79520385
Urinary casts 38.69 10.17 30 222698 1189 79520471
Pneumonia influenzal 38.52 10.17 44 222684 2860 79518800
Haematocrit decreased 38.37 10.17 298 222430 61014 79460646
Monocyte count decreased 38.29 10.17 46 222682 3155 79518505
Respiratory arrest 37.82 10.17 64 222664 57486 79464174
Toxic epidermal necrolysis 37.54 10.17 233 222495 44348 79477312
Band neutrophil percentage increased 37.50 10.17 20 222708 409 79521251
Blood potassium decreased 37.25 10.17 240 222488 46272 79475388
Meningitis aseptic 36.82 10.17 68 222660 6860 79514800
Blood pressure diastolic abnormal 36.77 10.17 5 222723 19197 79502463
Graft versus host disease in liver 36.77 10.17 34 222694 1720 79519940
Prescribed overdose 36.76 10.17 31 222697 37852 79483808
Injection site haemorrhage 36.54 10.17 16 222712 27854 79493806
Cells in urine 36.49 10.17 16 222712 208 79521452
Cardiogenic shock 36.33 10.17 38 222690 41876 79479784
Blood creatine phosphokinase increased 36.08 10.17 82 222646 66008 79455652
Device malfunction 35.80 10.17 8 222720 21440 79500220
Rash pruritic 35.76 10.17 331 222397 71298 79450362
Blood pressure diastolic decreased 35.61 10.17 20 222708 30196 79491464
Sleep disorder due to a general medical condition 35.58 10.17 104 222624 14173 79507487
Gastrointestinal disorder 35.55 10.17 198 222530 122007 79399653
Mantle cell lymphoma 35.21 10.17 30 222698 1361 79520299
Status epilepticus 35.17 10.17 151 222577 24890 79496770
Joint range of motion decreased 35.14 10.17 25 222703 33257 79488403
Ulcer 35.09 10.17 20 222708 29952 79491708
Bilirubin urine present 35.08 10.17 18 222710 339 79521321
Urine leukocyte esterase 34.84 10.17 15 222713 186 79521474
Ageusia 34.81 10.17 114 222614 16518 79505142
Plasma cell leukaemia 34.34 10.17 33 222695 1753 79519907
Anaphylactic shock 34.27 10.17 30 222698 35966 79485694
Colitis ulcerative 34.25 10.17 28 222700 34714 79486946
Central nervous system lesion 33.91 10.17 98 222630 13270 79508390
Escherichia sepsis 33.83 10.17 74 222654 8434 79513226
pH urine increased 33.78 10.17 19 222709 433 79521227
Pulmonary embolism 33.75 10.17 670 222058 170984 79350676
Injection site pruritus 33.74 10.17 41 222687 42242 79479418
Staphylococcal infection 33.57 10.17 278 222450 58017 79463643
Leukaemia recurrent 33.41 10.17 40 222688 2734 79518926
Therapeutic response shortened 33.23 10.17 3 222725 15860 79505800
Rectal haemorrhage 33.11 10.17 106 222622 76194 79445466
Differentiation syndrome 33.07 10.17 38 222690 2486 79519174
Metabolic acidosis 32.86 10.17 119 222609 82410 79439250
Brain stem stroke 32.67 10.17 22 222706 697 79520963
Pulmonary thrombosis 32.61 10.17 91 222637 12080 79509580
Blood thyroid stimulating hormone increased 32.60 10.17 79 222649 9629 79512031
Sleep disorder 32.51 10.17 126 222602 85551 79436109
Carpal tunnel syndrome 32.40 10.17 124 222604 19404 79502256
Pneumonia bacterial 32.28 10.17 123 222605 19208 79502452
Fatigue 32.25 10.17 3014 219714 926713 78594947
Herpes simplex encephalitis 32.21 10.17 22 222706 714 79520946
Pneumocystis jirovecii pneumonia 31.97 10.17 177 222551 32331 79489329
Disseminated mucormycosis 31.88 10.17 22 222706 726 79520934
Transplant failure 31.82 10.17 51 222677 4590 79517070
Epstein-Barr virus associated lymphoproliferative disorder 31.66 10.17 44 222684 3488 79518172
Monoclonal immunoglobulin increased 31.58 10.17 13 222715 143 79521517
Protein urine present 31.54 10.17 80 222648 10032 79511628
Obstructive airways disorder 31.45 10.17 25 222703 31434 79490226
Leukocyturia 31.44 10.17 33 222695 1950 79519710
Sciatica 31.25 10.17 28 222700 33194 79488466
Mental status changes 31.23 10.17 305 222423 66654 79455006
Accidental exposure to product 31.18 10.17 25 222703 31297 79490363
Breast cancer 31.15 10.17 29 222699 33752 79487908
Immune thrombocytopenia 31.15 10.17 115 222613 17690 79503970
Electrocardiogram QT prolonged 31.13 10.17 138 222590 90248 79431412
Extravasation 31.08 10.17 45 222683 3705 79517955
Therapeutic response decreased 31.06 10.17 90 222638 66763 79454897
Clostridium difficile infection 31.02 10.17 215 222513 42470 79479190
Hepatic cirrhosis 30.98 10.17 31 222697 34875 79486785
Injection site mass 30.87 10.17 9 222719 20175 79501485
Pseudomonal sepsis 30.82 10.17 59 222669 6115 79515545
Device issue 30.45 10.17 19 222709 27089 79494571
Nervous system disorder 30.38 10.17 152 222576 26704 79494956
Blister 30.34 10.17 202 222526 119274 79402386
Vomiting 30.20 10.17 1536 221192 664292 78857368
Pneumonia pneumococcal 29.96 10.17 46 222682 3991 79517669
Myalgia 29.84 10.17 353 222375 185288 79336372
Streptococcal bacteraemia 29.49 10.17 43 222685 3563 79518097
Angioedema 29.38 10.17 111 222617 75924 79445736
Herpes zoster meningoencephalitis 29.23 10.17 21 222707 740 79520920
Pneumonia viral 29.14 10.17 73 222655 9085 79512575
Metastases to bone 29.03 10.17 16 222712 24411 79497249
Dyslalia 28.95 10.17 24 222704 1048 79520612
Pleural effusion 28.89 10.17 568 222160 144694 79376966
Band neutrophil count increased 28.72 10.17 20 222708 670 79520990
Monoclonal immunoglobulin present 28.70 10.17 24 222704 1061 79520599
Viral haemorrhagic cystitis 28.65 10.17 32 222696 2029 79519631
Systemic candida 28.59 10.17 60 222668 6646 79515014
CD4 lymphocytes decreased 28.52 10.17 36 222692 2598 79519062
Multiple sclerosis relapse 28.47 10.17 225 222503 46308 79475352
Stevens-Johnson syndrome 28.30 10.17 197 222531 38969 79482691
Melaena 28.27 10.17 82 222646 60808 79460852
Mean cell haemoglobin concentration increased 28.17 10.17 22 222706 881 79520779
Gastrointestinal haemorrhage 28.14 10.17 270 222458 147449 79374211
Cytomegalovirus chorioretinitis 28.07 10.17 53 222675 5437 79516223
Surgery 28.07 10.17 30 222698 32736 79488924
Product quality issue 28.05 10.17 32 222696 33908 79487752
Lupus-like syndrome 28.03 10.17 3 222725 13854 79507806
Listeriosis 28.02 10.17 33 222695 2217 79519443
Fall 28.01 10.17 1096 221632 486533 79035127
Acute lymphocytic leukaemia 27.97 10.17 50 222678 4919 79516741
Blood pressure systolic abnormal 27.67 10.17 7 222721 17240 79504420
Alanine aminotransferase increased 27.56 10.17 621 222107 161949 79359711
Blood loss anaemia 27.50 10.17 5 222723 15493 79506167
Candida infection 27.49 10.17 192 222536 38022 79483638
Pneumonia respiratory syncytial viral 27.41 10.17 30 222698 1860 79519800
Herpes ophthalmic 27.39 10.17 27 222701 1480 79520180
Interstitial lung disease 27.29 10.17 193 222535 112407 79409253
Eosinophil percentage increased 27.23 10.17 27 222701 1491 79520169
Joint stiffness 27.21 10.17 45 222683 40785 79480875
Post herpetic neuralgia 27.09 10.17 35 222693 2586 79519074
Meningitis 27.02 10.17 73 222655 9509 79512151
CSF oligoclonal band present 26.95 10.17 16 222712 405 79521255
Device difficult to use 26.82 10.17 3 222725 13382 79508278
Leukopenia 26.79 10.17 466 222262 116047 79405613
Fungal infection 26.73 10.17 204 222524 41544 79480116
Squamous cell carcinoma of skin 26.56 10.17 93 222635 13940 79507720
Stress 26.55 10.17 123 222605 79489 79442171
Frequent bowel movements 26.49 10.17 26 222702 29513 79492147
Bone marrow transplant 26.43 10.17 26 222702 1422 79520238
Lower respiratory tract infection fungal 26.34 10.17 21 222707 867 79520793
Pseudomonas infection 26.31 10.17 122 222606 20781 79500879
Diabetes mellitus 26.21 10.17 121 222607 78269 79443391
Miosis 26.13 10.17 6 222722 15783 79505877
Febrile infection 26.07 10.17 39 222689 3307 79518353
Needle issue 26.01 10.17 3 222725 13065 79508595
Enterococcal sepsis 26.00 10.17 35 222693 2691 79518969
Lipaemic index score 25.95 10.17 11 222717 131 79521529
Herpes simplex viraemia 25.93 10.17 16 222712 435 79521225
Eczema herpeticum 25.92 10.17 14 222714 294 79521366
Campylobacter gastroenteritis 25.83 10.17 25 222703 1340 79520320
Drug tolerance decreased 25.78 10.17 3 222725 12975 79508685
Urine oxalate increased 25.76 10.17 13 222715 236 79521424
Mean cell haemoglobin decreased 25.74 10.17 55 222673 6169 79515491
Disseminated intravascular coagulation 25.73 10.17 180 222548 35662 79485998
Premature delivery 25.61 10.17 17 222711 23450 79498210
Renal impairment 25.59 10.17 599 222129 157184 79364476
Red cell distribution width decreased 25.56 10.17 30 222698 2008 79519652
Somnolence 25.47 10.17 492 222236 238489 79283171
Wheezing 25.42 10.17 206 222522 116458 79405202
Pulmonary arterial hypertension 25.40 10.17 25 222703 28341 79493319
Oral herpes 25.36 10.17 147 222581 27307 79494353
Metastases to liver 25.30 10.17 25 222703 28289 79493371
Treatment noncompliance 25.29 10.17 69 222659 52199 79469461
Myoclonic dystonia 25.17 10.17 9 222719 65 79521595
Infusion site pain 25.17 10.17 92 222636 14084 79507576
Muscle rigidity 25.15 10.17 12 222716 19870 79501790
Respiratory depression 25.15 10.17 24 222704 27606 79494054
Blood pressure diastolic increased 25.15 10.17 5 222723 14537 79507123
Posterior reversible encephalopathy syndrome 25.11 10.17 142 222586 26139 79495521
Magnetic resonance imaging abnormal 25.09 10.17 39 222689 3420 79518240
Liver injury 25.02 10.17 78 222650 56536 79465124
Tri-iodothyronine free increased 24.95 10.17 13 222715 253 79521407
Rhinovirus infection 24.89 10.17 63 222665 7890 79513770
Abdominal wall infection 24.87 10.17 10 222718 103 79521557
Klebsiella bacteraemia 24.77 10.17 36 222692 2974 79518686
Primary myelofibrosis 24.68 10.17 11 222717 149 79521511
Creutzfeldt-Jakob disease 24.54 10.17 12 222716 203 79521457
Acute myocardial infarction 24.54 10.17 121 222607 76915 79444745
Geotrichum infection 24.51 10.17 21 222707 960 79520700
Neutropenic infection 24.44 10.17 32 222696 2395 79519265
Anti-thyroid antibody positive 24.39 10.17 16 222712 485 79521175
Joint injury 24.35 10.17 31 222697 31304 79490356
Urobilinogen urine increased 24.31 10.17 18 222710 665 79520995
Strongyloidiasis 24.26 10.17 41 222687 3857 79517803
Idiopathic pneumonia syndrome 24.17 10.17 17 222711 579 79521081
Cellulitis enterococcal 24.07 10.17 8 222720 45 79521615
Myelodysplastic syndrome 24.05 10.17 156 222572 30145 79491515
Tumour flare 23.99 10.17 22 222706 1101 79520559
Cyanosis 23.96 10.17 21 222707 25161 79496499
Stenotrophomonas infection 23.90 10.17 40 222688 3733 79517927
Pregnancy 23.66 10.17 24 222704 26827 79494833
Red blood cells urine 23.62 10.17 18 222710 695 79520965
Lymphadenopathy 23.60 10.17 240 222488 53007 79468653
Depressed mood 23.46 10.17 64 222664 48416 79473244
Haemophilus sepsis 23.36 10.17 8 222720 50 79521610
Lip dry 23.35 10.17 7 222721 15411 79506249
Red blood cell count increased 23.25 10.17 42 222686 4166 79517494
Tri-iodothyronine free decreased 23.18 10.17 14 222714 366 79521294
Diaphragmatic injury 23.09 10.17 10 222718 126 79521534
Aspartate aminotransferase increased 23.00 10.17 528 222200 138113 79383547
Metastases to lung 22.92 10.17 11 222717 18152 79503508
NPM1 gene mutation 22.81 10.17 10 222718 130 79521530
Paranoia 22.70 10.17 13 222715 19419 79502241
Dystonia 22.69 10.17 16 222712 21383 79500277
Migraine 22.68 10.17 147 222581 87346 79434314
Abdominal pain 22.48 10.17 875 221853 388694 79132966
Anti-platelet antibody positive 22.47 10.17 13 222715 313 79521347
CSF measles antibody positive 22.47 10.17 8 222720 57 79521603
Staphylococcal sepsis 22.40 10.17 91 222637 14635 79507025
Haematochezia 22.34 10.17 148 222580 87497 79434163
Swollen tongue 22.29 10.17 54 222674 42516 79479144
Gait disturbance 22.17 10.17 427 222301 207079 79314581
Epstein-Barr viraemia 22.09 10.17 29 222699 2176 79519484
Rubella antibody positive 22.00 10.17 8 222720 61 79521599
Meningitis cryptococcal 21.98 10.17 37 222691 3469 79518191
Varicella virus test positive 21.83 10.17 11 222717 199 79521461
Device expulsion 21.79 10.17 24 222704 25837 79495823
White blood cells urine 21.66 10.17 15 222713 498 79521162
Urine bilirubin decreased 21.65 10.17 10 222718 148 79521512
Exostosis 21.59 10.17 10 222718 16848 79504812
Thyroid stimulating immunoglobulin 21.56 10.17 8 222720 65 79521595
Bone marrow failure 21.53 10.17 228 222500 50879 79470781
Blast cell count increased 21.53 10.17 23 222705 1387 79520273
Capillary leak syndrome 21.46 10.17 39 222689 3886 79517774
Blood creatinine decreased 21.45 10.17 59 222669 7766 79513894
Enterococcal bacteraemia 21.43 10.17 34 222694 3034 79518626
Therapy interrupted 21.39 10.17 34 222694 31307 79490353
Tendonitis 21.34 10.17 21 222707 23809 79497851
Haemorrhagic disorder 21.08 10.17 24 222704 1554 79520106
Neutrophil Pelger-Huet anomaly present 21.05 10.17 13 222715 354 79521306
Partial seizures 21.05 10.17 64 222664 8914 79512746
Meningitis listeria 21.02 10.17 20 222708 1049 79520611
Diabetes mellitus inadequate control 21.02 10.17 22 222706 24242 79497418
Skin exfoliation 21.01 10.17 241 222487 54859 79466801
Peripheral sensory neuropathy 21.00 10.17 82 222646 12951 79508709
Chimerism 20.93 10.17 12 222716 284 79521376
Asthma 20.90 10.17 259 222469 134836 79386824
Road traffic accident 20.86 10.17 58 222670 43606 79478054
Neutrophil percentage decreased 20.86 10.17 18 222710 831 79520829
Mean cell haemoglobin concentration decreased 20.73 10.17 42 222686 4537 79517123
Klebsiella infection 20.71 10.17 93 222635 15627 79506033
Poisoning 20.70 10.17 24 222704 25248 79496412
Fungaemia 20.66 10.17 42 222686 4549 79517111
Lymph node palpable 20.62 10.17 10 222718 166 79521494
Diabetic ketoacidosis 20.58 10.17 40 222688 34082 79487578
Fibrin D dimer increased 20.58 10.17 62 222666 8592 79513068
Duodenal ulcer 20.52 10.17 10 222718 16359 79505301
Chest pain 20.48 10.17 616 222112 281688 79239972
Hiatus hernia 20.35 10.17 21 222707 23291 79498369
Angina pectoris 20.32 10.17 75 222653 51657 79470003
Acute disseminated encephalomyelitis 20.31 10.17 12 222716 301 79521359
Pneumonia parainfluenzae viral 20.27 10.17 12 222716 302 79521358
Marrow hyperplasia 20.24 10.17 24 222704 1624 79520036
Colitis microscopic 20.16 10.17 3 222725 10765 79510895
Cytomegalovirus colitis 20.07 10.17 42 222686 4643 79517017
Herpes zoster meningitis 19.94 10.17 10 222718 179 79521481
Aphasia 19.93 10.17 209 222519 46523 79475137
Procedural pain 19.92 10.17 21 222707 23063 79498597
Renal tubular disorder 19.91 10.17 51 222677 6435 79515225
Blood glucose increased 19.90 10.17 215 222513 114760 79406900
Live birth 19.89 10.17 14 222714 18730 79502930
Myelocyte percentage increased 19.86 10.17 11 222717 243 79521417
Focal myositis 19.71 10.17 6 222722 24 79521636
Coronary artery disease 19.63 10.17 105 222623 65369 79456291
Aplasia 19.52 10.17 57 222671 7763 79513897
Parkinsonism 19.51 10.17 11 222717 16573 79505087
Cytokine storm 19.50 10.17 19 222709 1027 79520633
Polyarthritis 19.49 10.17 5 222723 12197 79509463
Lung infiltration 19.45 10.17 120 222608 22792 79498868
Bronchiolitis obliterans syndrome 19.42 10.17 12 222716 327 79521333
Iron deficiency anaemia 19.33 10.17 26 222702 25646 79496014
Haemodialysis 19.27 10.17 101 222627 18067 79503593
Impaired work ability 19.23 10.17 16 222712 19665 79501995
Tremor 19.15 10.17 616 222112 169467 79352193
Hypouricaemia 19.11 10.17 13 222715 419 79521241
Injection site urticaria 19.10 10.17 6 222722 12820 79508840
Target skin lesion 19.02 10.17 9 222719 141 79521519
Escherichia infection 19 10.17 100 222628 17917 79503743
Blood brain barrier defect 18.91 10.17 9 222719 143 79521517
Splenic embolism 18.86 10.17 10 222718 202 79521458
Dilatation intrahepatic duct acquired 18.85 10.17 16 222712 722 79520938
Oesophageal carcinoma 18.77 10.17 4 222724 11080 79510580
Ventricular fibrillation 18.76 10.17 38 222690 31888 79489772
Tenosynovitis 18.76 10.17 10 222718 15544 79506116
Pallor 18.75 10.17 74 222654 49988 79471672
Cardiac arrest 18.73 10.17 353 222375 171743 79349917
Protein total increased 18.73 10.17 36 222692 3743 79517917
Haematopoietic stem cell mobilisation 18.68 10.17 10 222718 206 79521454
CSF test abnormal 18.63 10.17 14 222714 529 79521131
Flushing 18.51 10.17 348 222380 87920 79433740
Cardiac disorder 18.50 10.17 272 222456 65485 79456175
Sepsis syndrome 18.48 10.17 22 222706 1495 79520165
Withdrawal syndrome 18.45 10.17 29 222699 26825 79494835
Atrioventricular block first degree 18.33 10.17 6 222722 12485 79509175
Myelocyte count increased 18.28 10.17 16 222712 753 79520907
Atypical pneumonia 18.16 10.17 50 222678 6586 79515074
Dyslipidaemia 18.14 10.17 5 222723 11628 79510032
Hypertension 18.10 10.17 748 221980 330244 79191416
Light chain disease 18.09 10.17 10 222718 220 79521440
Extrapyramidal disorder 18.08 10.17 22 222706 22657 79499003
Loss of personal independence in daily activities 18.08 10.17 191 222537 102389 79419271
Panniculitis 18.05 10.17 6 222722 12365 79509295
Aggression 18.03 10.17 77 222651 50881 79470779
Hypoxia 18.00 10.17 396 222332 102847 79418813
Neutrophil count abnormal 17.98 10.17 34 222694 3492 79518168
Human herpesvirus 6 encephalitis 17.94 10.17 15 222713 663 79520997
Platelet count abnormal 17.89 10.17 41 222687 4821 79516839
Fear 17.88 10.17 21 222707 21965 79499695
Factor XIII Inhibition 17.87 10.17 6 222722 35 79521625
Nocardiosis 17.79 10.17 45 222683 5634 79516026
Meningoencephalitis bacterial 17.70 10.17 10 222718 230 79521430
Oroantral fistula 17.58 10.17 12 222716 389 79521271
Blood immunoglobulin G decreased 17.54 10.17 33 222695 3376 79518284
Joint dislocation 17.52 10.17 13 222715 16926 79504734
Herpes simplex pneumonia 17.51 10.17 7 222721 71 79521589
Corneal deposits 17.45 10.17 13 222715 485 79521175
Abortion spontaneous 17.45 10.17 35 222693 29472 79492188
Infection 17.44 10.17 834 221894 240878 79280782
Sputum discoloured 17.43 10.17 21 222707 21722 79499938
Thyroxine free decreased 17.35 10.17 18 222710 1049 79520611
Meningitis bacterial 17.35 10.17 29 222699 2703 79518957
Brain herniation 17.31 10.17 53 222675 7410 79514250
Palpitations 17.30 10.17 249 222479 126361 79395299
Acanthamoeba infection 17.28 10.17 13 222715 492 79521168
Encephalitis brain stem 17.28 10.17 10 222718 241 79521419
Lung neoplasm malignant 17.27 10.17 32 222696 27760 79493900
Myeloblast percentage decreased 17.07 10.17 6 222722 41 79521619
Pyogenic granuloma 17.06 10.17 13 222715 502 79521158
Brain oedema 17.05 10.17 125 222603 25138 79496522
Injection site rash 17.05 10.17 15 222713 17939 79503721
Product complaint 16.97 10.17 8 222720 13341 79508319
Atrial flutter 16.96 10.17 111 222617 21514 79500146
Contusion 16.87 10.17 303 222425 148473 79373187
Oesophagitis 16.86 10.17 121 222607 24168 79497492
Haemorrhage intracranial 16.77 10.17 128 222600 26065 79495595
Coronary artery stenosis 16.63 10.17 7 222721 12477 79509183
Blood pressure decreased 16.42 10.17 188 222540 99278 79422382
Hepatitis fulminant 16.31 10.17 51 222677 7211 79514449
Sideroblastic anaemia 16.23 10.17 10 222718 271 79521389
Amyloidosis 16.23 10.17 28 222700 2678 79518982
Rash macular 16.20 10.17 137 222591 28762 79492898
Thyroid stimulating immunoglobulin increased 16.17 10.17 7 222721 88 79521572
Septic embolus 16.11 10.17 24 222704 2027 79519633
Red blood cell elliptocytes present 16.08 10.17 9 222719 203 79521457
Follicular mucinosis 16.05 10.17 5 222723 22 79521638
Cytomegalovirus gastroenteritis 16.00 10.17 12 222716 452 79521208
Full blood count increased 15.99 10.17 13 222715 552 79521108
Serotonin syndrome 15.96 10.17 68 222660 44959 79476701
Neuralgic amyotrophy 15.94 10.17 10 222718 280 79521380
Autoimmune thyroiditis 15.91 10.17 36 222692 4197 79517463
Gastroenteritis norovirus 15.90 10.17 30 222698 3076 79518584
Vaginal cellulitis 15.90 10.17 7 222721 92 79521568
Device breakage 15.89 10.17 5 222723 10670 79510990
Delayed engraftment 15.88 10.17 10 222718 282 79521378
Nightmare 15.87 10.17 30 222698 25831 79495829
Hypoglossal nerve paralysis 15.87 10.17 5 222723 23 79521637
Urinary tract infection enterococcal 15.85 10.17 31 222697 3264 79518396
Haemolytic uraemic syndrome 15.80 10.17 37 222691 4412 79517248
Hyperpyrexia 15.78 10.17 45 222683 6047 79515613
Pneumonia klebsiella 15.78 10.17 40 222688 5014 79516646
Pneumonia pseudomonal 15.64 10.17 44 222684 5867 79515793
Aspartate aminotransferase 15.64 10.17 13 222715 570 79521090
Abdominal wall wound 15.63 10.17 7 222721 96 79521564
Neutrophil morphology abnormal 15.63 10.17 7 222721 96 79521564
Psychotic disorder 15.63 10.17 61 222667 41341 79480319
Accessory spleen 15.62 10.17 9 222719 215 79521445
Neutropenic colitis 15.61 10.17 43 222685 5664 79515996
Arteriosclerosis coronary artery 15.61 10.17 16 222712 17800 79503860
Skin ulcer 15.60 10.17 88 222640 54062 79467598
Rash papulosquamous 15.57 10.17 8 222720 151 79521509
Mucosal disorder 15.55 10.17 32 222696 3496 79518164
BK virus infection 15.51 10.17 57 222671 8747 79512913
Transfusion reaction 15.45 10.17 22 222706 1784 79519876
Encephalomyelitis 15.29 10.17 9 222719 224 79521436
Hyperkalaemia 15.28 10.17 226 222502 114172 79407488
Metastases to lymph nodes 15.24 10.17 5 222723 10392 79511268
Post procedural complication 15.20 10.17 27 222701 23802 79497858
Metapneumovirus pneumonia 15.17 10.17 6 222722 59 79521601
Neuromyotonia 15.13 10.17 7 222721 104 79521556
Product prescribing error 15.08 10.17 69 222659 44744 79476916
Chronic obstructive pulmonary disease 15.07 10.17 159 222569 85260 79436400
Reticulocytosis 15.02 10.17 12 222716 497 79521163
Lung disorder 15.02 10.17 148 222580 80409 79441251
Productive cough 14.95 10.17 166 222562 88165 79433495
Polyomavirus viraemia 14.90 10.17 21 222707 1686 79519974
Chronic sinusitis 14.81 10.17 9 222719 13017 79508643
Klebsiella test positive 14.75 10.17 21 222707 1702 79519958
Nodule 14.72 10.17 26 222702 22968 79498692
CSF lactate increased 14.65 10.17 3 222725 0 79521660
Dyspnoea exertional 14.59 10.17 164 222564 86909 79434751
Peripheral swelling 14.59 10.17 610 222118 269007 79252653
Prostate cancer 14.58 10.17 46 222682 33222 79488438
Autoimmune haemolytic anaemia 14.55 10.17 54 222674 8326 79513334
Mean cell haemoglobin increased 14.53 10.17 35 222693 4250 79517410
Injection site warmth 14.51 10.17 12 222716 14795 79506865
Postural tremor 14.50 10.17 14 222714 748 79520912
Mitochondrial DNA mutation 14.50 10.17 11 222717 422 79521238
Heart rate decreased 14.48 10.17 126 222602 70190 79451470
Osteopenia 14.45 10.17 18 222710 18346 79503314
Coma 14.44 10.17 196 222532 100453 79421207
Herpes simplex meningoencephalitis 14.42 10.17 6 222722 68 79521592
Crystal nephropathy 14.37 10.17 19 222709 1436 79520224
Loss of consciousness 14.36 10.17 358 222370 167585 79354075
Coronary artery occlusion 14.29 10.17 13 222715 15302 79506358
Fibromyalgia 14.29 10.17 113 222615 64227 79457433
Creatinine urine decreased 14.26 10.17 9 222719 255 79521405
Altered state of consciousness 14.24 10.17 186 222542 43636 79478024
Dry skin 14.23 10.17 268 222460 67727 79453933
Chronic lymphocytic leukaemia transformation 14.19 10.17 9 222719 257 79521403
Cytomegalovirus hepatitis 14.16 10.17 14 222714 770 79520890
Human chorionic gonadotropin increased 14.14 10.17 17 222711 1167 79520493
Duodenal stenosis 14.12 10.17 14 222714 773 79520887
Drug reaction with eosinophilia and systemic symptoms 14.07 10.17 255 222473 63989 79457671
Granulocyte percentage 14.04 10.17 6 222722 73 79521587
Herpes zoster reactivation 14.00 10.17 8 222720 188 79521472
Obliterative bronchiolitis 13.98 10.17 28 222700 3000 79518660
Rash papular 13.98 10.17 107 222621 21809 79499851
Peripheral arterial occlusive disease 13.95 10.17 3 222725 8255 79513405
Cytomegalovirus enterocolitis 13.92 10.17 20 222708 1635 79520025
Disturbance in attention 13.86 10.17 84 222644 50717 79470943
Pneumococcal sepsis 13.85 10.17 20 222708 1642 79520018
Joint effusion 13.81 10.17 18 222710 17996 79503664
Viraemia 13.81 10.17 27 222701 2842 79518818
Respiratory acidosis 13.80 10.17 7 222721 11193 79510467
Right ventricular failure 13.78 10.17 28 222700 23469 79498191
Immunodeficiency common variable 13.78 10.17 10 222718 358 79521302
Candida sepsis 13.78 10.17 25 222703 2488 79519172
Haematocrit increased 13.73 10.17 33 222695 4001 79517659
CSF cell count increased 13.73 10.17 7 222721 130 79521530
Pulmonary haemorrhage 13.72 10.17 79 222649 14638 79507022
Nasal congestion 13.71 10.17 142 222586 76410 79445250
Burning sensation 13.65 10.17 235 222493 58397 79463263
Periorbital swelling 13.64 10.17 27 222701 2869 79518791
Rash vesicular 13.58 10.17 42 222686 5903 79515757
Polyp 13.58 10.17 3 222725 8104 79513556
Disease progression 13.48 10.17 637 222091 183725 79337935
Asphyxia 13.46 10.17 8 222720 11712 79509948
Fumbling 13.45 10.17 7 222721 136 79521524
Tri-iodothyronine free abnormal 13.44 10.17 5 222723 41 79521619
Achromobacter infection 13.40 10.17 7 222721 137 79521523
Body temperature increased 13.39 10.17 186 222542 44234 79477426
Tooth deposit 13.37 10.17 9 222719 285 79521375
Autoimmune disorder 13.37 10.17 16 222712 16596 79505064
Avulsion fracture 13.34 10.17 9 222719 286 79521374
Pulmonary sepsis 13.32 10.17 31 222697 3681 79517979
Product administration error 13.29 10.17 45 222683 31801 79489859
Accidental overdose 13.29 10.17 61 222667 39520 79482140
Epstein-Barr virus infection reactivation 13.26 10.17 21 222707 1871 79519789
Actinomycosis 13.25 10.17 16 222712 1103 79520557
Monocyte count increased 13.25 10.17 62 222666 10599 79511061
Disability 13.24 10.17 17 222711 17103 79504557
Immature granulocyte percentage increased 13.22 10.17 6 222722 85 79521575
Lower respiratory tract infection 13.16 10.17 268 222460 128952 79392708
Cardiac failure congestive 13.16 10.17 300 222428 142102 79379558
Refractoriness to platelet transfusion 13.13 10.17 7 222721 143 79521517
Pneumonitis 13.13 10.17 241 222487 60619 79461041
Nephropathy 13.12 10.17 58 222670 9680 79511980
Immunosuppressant drug level increased 13.11 10.17 55 222673 8972 79512688
Urine bilirubin increased 13.09 10.17 7 222721 144 79521516
Genital herpes 13.07 10.17 22 222706 2062 79519598
Drug tolerance 13.03 10.17 4 222724 8671 79512989
Monocyte percentage decreased 13.02 10.17 9 222719 298 79521362
Poikiloderma 12.97 10.17 10 222718 393 79521267
Model for end stage liver disease score increased 12.95 10.17 4 222724 17 79521643
Procalcitonin increased 12.94 10.17 27 222701 2979 79518681
Anti-thyroid antibody 12.93 10.17 5 222723 46 79521614
Metastases to central nervous system 12.93 10.17 16 222712 16359 79505301
Dysgeusia 12.89 10.17 228 222500 56949 79464711
Eosinophil percentage decreased 12.89 10.17 9 222719 303 79521357
Erythema multiforme 12.88 10.17 89 222639 17562 79504098
Forced expiratory volume decreased 12.87 10.17 3 222725 7811 79513849
Intentional product misuse to child 12.86 10.17 6 222722 91 79521569
Emphysema 12.80 10.17 16 222712 16284 79505376
Immunosuppression 12.78 10.17 70 222658 12733 79508927
Fracture 12.77 10.17 26 222702 21775 79499885
Pulmonary mucormycosis 12.74 10.17 16 222712 1149 79520511
Emotional distress 12.60 10.17 63 222665 39906 79481754
Post-depletion B-cell recovery 12.59 10.17 4 222724 19 79521641
Neurotrophic keratopathy 12.58 10.17 3 222725 3 79521657
Spinal fracture 12.57 10.17 90 222638 17964 79503696
Retinal depigmentation 12.55 10.17 9 222719 316 79521344
Caesarean section 12.48 10.17 10 222718 12525 79509135
Pseudomonal bacteraemia 12.47 10.17 27 222701 3055 79518605
Pulmonary function test decreased 12.45 10.17 3 222725 7634 79514026
Alveolitis necrotising 12.42 10.17 4 222724 20 79521640
Insomnia 12.41 10.17 819 221909 244351 79277309
Sinusitis 12.40 10.17 434 222294 195067 79326593
Hepatic encephalopathy 12.38 10.17 31 222697 24135 79497525
Coombs direct test positive 12.38 10.17 10 222718 421 79521239
Oesophagopleural fistula 12.31 10.17 5 222723 53 79521607
Injection site induration 12.31 10.17 6 222722 9813 79511847
Glomerulonephritis minimal lesion 12.30 10.17 13 222715 774 79520886
Mean cell volume decreased 12.29 10.17 36 222692 4911 79516749
Pain in jaw 12.23 10.17 77 222651 46074 79475586
CNS ventriculitis 12.23 10.17 10 222718 428 79521232
Respiratory tract infection fungal 12.23 10.17 16 222712 1197 79520463
Adenomatous polyposis coli 12.21 10.17 8 222720 242 79521418
Hypothyroidism 12.20 10.17 210 222518 52182 79469478
Immune system disorder 12.17 10.17 62 222666 10967 79510693
Hepatosplenomegaly 12.17 10.17 41 222687 6028 79515632
Hyperhidrosis 12.13 10.17 326 222402 151166 79370494
Pericardial effusion 12.13 10.17 189 222539 46048 79475612
Glycosylated haemoglobin increased 12.13 10.17 22 222706 19238 79502422
Pancreatic carcinoma 12.12 10.17 12 222716 13565 79508095
Postoperative wound infection 12.10 10.17 11 222717 12950 79508710
Peripheral venous disease 12.09 10.17 16 222712 15893 79505767
JC virus CSF test positive 12.08 10.17 7 222721 169 79521491
Fear of injection 12.06 10.17 3 222725 7471 79514189
Serum ferritin increased 12.04 10.17 57 222671 9790 79511870
Device dislocation 12.03 10.17 35 222693 25935 79495725
Infusion site discomfort 12.02 10.17 17 222711 1370 79520290
Renal cancer 11.87 10.17 10 222718 12216 79509444
Blood thyroid stimulating hormone abnormal 11.82 10.17 14 222714 946 79520714
Corneal graft rejection 11.76 10.17 5 222723 60 79521600
Angioimmunoblastic T-cell lymphoma 11.73 10.17 10 222718 454 79521206
Bone density decreased 11.68 10.17 12 222716 13335 79508325
Babesiosis 11.67 10.17 9 222719 354 79521306
Systemic inflammatory response syndrome 11.66 10.17 63 222665 11402 79510258
Glomerulosclerosis 11.62 10.17 15 222713 1107 79520553
Electrocardiogram abnormal 11.57 10.17 18 222710 16719 79504941
Endotoxic shock 11.55 10.17 4 222724 26 79521634
Klebsiella sepsis 11.50 10.17 27 222701 3225 79518435
Oesophageal irritation 11.41 10.17 6 222722 119 79521541
Metapneumovirus infection 11.41 10.17 19 222709 1765 79519895
Glomerulonephritis chronic 11.41 10.17 8 222720 271 79521389
Cystitis viral 11.34 10.17 12 222716 716 79520944
Gastritis fungal 11.32 10.17 7 222721 191 79521469
Anhedonia 11.31 10.17 15 222713 14883 79506777
Neurosyphilis 11.29 10.17 4 222724 28 79521632
Ear swelling 11.29 10.17 18 222710 1613 79520047
Colorectal cancer 11.28 10.17 5 222723 8642 79513018
Testicular swelling 11.27 10.17 16 222712 1294 79520366
Bronchiectasis 11.25 10.17 29 222699 22357 79499303
Pulpitis dental 11.24 10.17 16 222712 1297 79520363
Jaundice cholestatic 11.24 10.17 9 222719 11275 79510385
Phyllodes tumour 11.17 10.17 4 222724 29 79521631
Vulvovaginal injury 11.16 10.17 8 222720 281 79521379
Hepatitis B reactivation 11.15 10.17 40 222688 6068 79515592
Ketoacidosis 11.13 10.17 4 222724 7850 79513810
Immature granulocyte count increased 11.13 10.17 11 222717 605 79521055
Platelet disorder 11.11 10.17 25 222703 2904 79518756
Cerebral toxoplasmosis 11.10 10.17 22 222706 2340 79519320
Dermatitis bullous 11.10 10.17 73 222655 14172 79507488
Tardive dyskinesia 11.08 10.17 8 222720 10563 79511097
Incorrect dose administered 11.08 10.17 149 222579 76481 79445179
Viral oesophagitis 11.06 10.17 3 222725 7 79521653
Pemphigoid 11.04 10.17 16 222712 15299 79506361
Paternal exposure timing unspecified 11.01 10.17 5 222723 71 79521589
Corneal lesion 11.01 10.17 5 222723 71 79521589
MELAS syndrome 11.00 10.17 7 222721 201 79521459
Lower limb fracture 10.97 10.17 31 222697 23184 79498476
Complications of transplant surgery 10.95 10.17 12 222716 745 79520915
SARS-CoV-2 RNA 10.94 10.17 4 222724 31 79521629
Tonsillar haemorrhage 10.94 10.17 8 222720 290 79521370
Hypokinesia 10.94 10.17 23 222705 19037 79502623
Sexual dysfunction 10.92 10.17 4 222724 7759 79513901
Transaminases increased 10.85 10.17 204 222524 51539 79470121
Thunderclap headache 10.80 10.17 9 222719 396 79521264
Peritonitis 10.78 10.17 41 222687 27995 79493665
White blood cell disorder 10.74 10.17 26 222702 3166 79518494
Graft versus host disease in lung 10.74 10.17 13 222715 899 79520761
Myasthenia gravis 10.73 10.17 8 222720 10391 79511269
Premature labour 10.71 10.17 5 222723 8385 79513275
Product storage error 10.70 10.17 18 222710 16208 79505452
Aspergillus test positive 10.68 10.17 12 222716 766 79520894
Adenoviral haemorrhagic cystitis 10.67 10.17 10 222718 515 79521145
Carotid artery occlusion 10.66 10.17 4 222724 7643 79514017
Eye infection fungal 10.60 10.17 10 222718 519 79521141
Viral infection 10.59 10.17 174 222554 42842 79478818
Injection site discolouration 10.58 10.17 4 222724 7610 79514050
Vitreous detachment 10.56 10.17 21 222707 2238 79519422
Haematoma 10.54 10.17 94 222634 52101 79469559
Acquired macroglossia 10.50 10.17 7 222721 218 79521442
Retinitis viral 10.50 10.17 6 222722 141 79521519
Menstrual disorder 10.50 10.17 30 222698 4037 79517623
Brain abscess 10.48 10.17 34 222694 4902 79516758
Choking 10.45 10.17 11 222717 12090 79509570
Dermatitis exfoliative generalised 10.43 10.17 44 222684 7197 79514463
Hyperplasia 10.42 10.17 15 222713 1228 79520432
Organising pneumonia 10.38 10.17 59 222669 10880 79510780
Dry mouth 10.37 10.17 178 222550 87841 79433819
Arteritis infective 10.36 10.17 5 222723 82 79521578
Blood glucose decreased 10.32 10.17 38 222690 26196 79495464
Glucose urine present 10.31 10.17 18 222710 1738 79519922
Oesophageal infection 10.30 10.17 11 222717 663 79520997
Angina unstable 10.30 10.17 19 222709 16508 79505152
Nasopharyngitis 10.28 10.17 592 222136 253289 79268371
Varicella zoster pneumonia 10.28 10.17 6 222722 147 79521513
Gastrointestinal candidiasis 10.26 10.17 9 222719 425 79521235
Candida test positive 10.25 10.17 14 222714 1092 79520568
Petechiae 10.24 10.17 95 222633 20470 79501190
Breast cancer stage I 10.22 10.17 3 222725 6697 79514963
Renal tubular necrosis 10.22 10.17 111 222617 24928 79496732
Pneumocystis jirovecii infection 10.20 10.17 24 222704 2870 79518790
Cataract subcapsular 10.19 10.17 13 222715 948 79520712
Blood glucose fluctuation 10.18 10.17 3 222725 6679 79514981

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D06BB03 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
CHEMOTHERAPEUTICS FOR TOPICAL USE
Antivirals
ATC D06BB53 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
CHEMOTHERAPEUTICS FOR TOPICAL USE
Antivirals
ATC J05AB01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Nucleosides and nucleotides excl. reverse transcriptase inhibitors
ATC S01AD03 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antivirals
FDA MoA N0000020060 DNA Polymerase Inhibitors
FDA EXT N0000175459 Nucleoside Analog
FDA EPC N0000175468 Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:36044 antiviral drugs
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000998 Antiviral Agents
FDA EPC N0000180187 Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor
FDA EPC N0000180188 Herpes Zoster Virus Nucleoside Analog DNA Polymerase Inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Herpes labialis indication 1475003
Herpes zoster indication 4740000 DOID:8536
Genital herpes simplex indication 33839006 DOID:8704
Varicella indication 38907003 DOID:8659
Herpes simplex indication 88594005 DOID:8566
Herpes simplex infection of skin indication 240475000
Recurrent herpes simplex labialis indication 402892009
Recurrent genital herpes simplex indication 402894005
Encephalitis due to Herpesvirus indication 428638009
Recurrent Mucocutaneous Herpes Simplex indication
Suppression of Recurrent Herpes Simplex Infection indication
Herpes zoster ophthalmicus off-label use 87513003
Granulomatosis Infantiseptica off-label use
Herpes Zoster Hepatitis off-label use
Neonatal Herpes Meningoencephalitis off-label use
Disseminated Herpes Simplex Neonatal Infection off-label use
Herpes Simplex Hepatitis off-label use
Prevention of Herpes Zoster in Immunocompromised Patient off-label use
Urinary tract obstruction contraindication 7163005 DOID:5200
Hypercholesterolemia contraindication 13644009
Myocardial infarction contraindication 22298006 DOID:5844
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Diabetes mellitus contraindication 73211009 DOID:9351
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Hyperglycemia contraindication 80394007 DOID:4195
Kidney disease contraindication 90708001 DOID:557
Hemolytic uremic syndrome contraindication 111407006 DOID:12554
Impaired renal function disorder contraindication 197663003
Cerebrovascular accident contraindication 230690007
Telangiectasia disorder contraindication 247479008
Pregnancy, function contraindication 289908002
Osteopenia contraindication 312894000
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Cardiovascular event risk contraindication 395112001
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Breastfeeding (mother) contraindication 413712001
Obesity contraindication 414916001 DOID:9970
Smokes tobacco daily contraindication 449868002
Vertebral Metastases contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.97 acidic
pKa2 13.01 acidic
pKa3 3.83 Basic
pKa4 2.12 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
50MG SITAVIG EPI HLTH N203791 April 12, 2013 RX TABLET BUCCAL 8791127 March 23, 2027 TREATMENT OF HERPES LABIALIS
50MG SITAVIG EPI HLTH N203791 April 12, 2013 RX TABLET BUCCAL 8747896 June 3, 2027 TREATMENT OF HERPES LABIALIS
50MG SITAVIG EPI HLTH N203791 April 12, 2013 RX TABLET BUCCAL 8592434 June 16, 2030 TREATMENT OF HERPES LABIALIS

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
3% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** AVACLYR FERA PHARMS LLC N202408 March 29, 2019 DISCN OINTMENT OPHTHALMIC March 29, 2026 INDICATED FOR THE TREATMENT OF ACUTE HERPETIC KERATITIS (DENDRITIC ULCERS) IN PATIENTS WITH HERPES SIMPLEX (HSV-1 AND HSV-2) VIRUS

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Purine nucleoside phosphorylase Enzyme Ki 4.04 CHEMBL
DNA polymerase catalytic subunit Enzyme INHIBITOR DRUG LABEL DRUG LABEL
DNA polymerase catalytic subunit Enzyme INHIBITOR WOMBAT-PK DRUG LABEL
Thymidine kinase Kinase INHIBITOR WOMBAT-PK DRUG LABEL
Thymidine kinase Kinase INHIBITOR WOMBAT-PK DRUG LABEL
Thymidine kinase Kinase WOMBAT-PK
Purine nucleoside phosphorylase Enzyme Kd 4.90 CHEMBL

External reference:

IDSource
4018781 VUID
N0000147084 NUI
D00222 KEGG_DRUG
69657-51-8 SECONDARY_CAS_RN
152535 RXNORM
C0001367 UMLSCUI
CHEBI:2453 CHEBI
AC2 PDB_CHEM_ID
CHEMBL1200380 ChEMBL_ID
CHEMBL184 ChEMBL_ID
DB00787 DRUGBANK_ID
D000212 MESH_DESCRIPTOR_UI
135398513 PUBCHEM_CID
4829 IUPHAR_LIGAND_ID
4435 INN_ID
X4HES1O11F UNII
372729009 SNOMEDCT_US
41193000 SNOMEDCT_US
72387009 SNOMEDCT_US
4018781 VANDF
4018782 VANDF
14023 MMSL
1579 MMSL
4132 MMSL
4133 MMSL
981 MMSL
d00001 MMSL
003016 NDDF
003017 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0093-3630 CREAM 50 mg TOPICAL NDA authorized generic 26 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0143-9657 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 23 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0143-9658 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRAVENOUS ANDA 23 sections
acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0168-0825 OINTMENT 50 mg TOPICAL ANDA 22 sections
Zovirax HUMAN PRESCRIPTION DRUG LABEL 1 0187-0993 OINTMENT 50 mg TOPICAL NDA 21 sections
Zovirax HUMAN PRESCRIPTION DRUG LABEL 1 0187-0994 CREAM 50 mg TOPICAL NDA 26 sections
Xerese HUMAN PRESCRIPTION DRUG LABEL 2 0187-5104 CREAM 50 mg TOPICAL NDA 26 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0378-8700 OINTMENT 50 mg TOPICAL ANDA 20 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0378-8700 OINTMENT 50 mg TOPICAL ANDA 20 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0378-8712 SUSPENSION 200 mg ORAL NDA authorized generic 20 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0378-8712 SUSPENSION 200 mg ORAL NDA authorized generic 20 sections
Zovirax HUMAN PRESCRIPTION DRUG LABEL 1 0378-9735 SUSPENSION 200 mg ORAL NDA 20 sections
Zovirax HUMAN PRESCRIPTION DRUG LABEL 1 0378-9735 SUSPENSION 200 mg ORAL NDA 20 sections
acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0440-7033 TABLET 800 mg ORAL ANDA 22 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0472-0082 SUSPENSION 200 mg ORAL ANDA 19 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0591-1159 OINTMENT 50 mg TOPICAL NDA authorized generic 22 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0713-0630 OINTMENT 50 mg TOPICAL ANDA 19 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0713-0630 OINTMENT 50 mg TOPICAL ANDA 19 sections
ACYCLOVIR HUMAN PRESCRIPTION DRUG LABEL 1 0904-5789 CAPSULE 200 mg ORAL ANDA 21 sections
acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0904-5790 TABLET 400 mg ORAL ANDA 22 sections
acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0904-5790 TABLET 400 mg ORAL ANDA 22 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 10544-039 TABLET 400 mg ORAL ANDA 20 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 10544-089 CAPSULE 200 mg ORAL ANDA 20 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 10544-101 CAPSULE 200 mg ORAL ANDA 22 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 10544-102 TABLET 400 mg ORAL ANDA 22 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 10544-103 TABLET 800 mg ORAL ANDA 22 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 12634-520 TABLET 400 mg ORAL ANDA 22 sections
acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 12634-697 TABLET 800 mg ORAL ANDA 22 sections
acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 13668-515 OINTMENT 50 mg TOPICAL ANDA 16 sections
acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 13668-515 OINTMENT 50 mg TOPICAL ANDA 16 sections