cinchocaine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| local anaesthetics | 859 | 85-79-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Heart sounds | 63.13 | 58.51 | 10 | 546 | 956 | 79742876 |
| Prolonged expiration | 60.39 | 58.51 | 10 | 546 | 1261 | 79742571 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C05AD04 | CARDIOVASCULAR SYSTEM VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Local anesthetics |
| ATC | D04AB02 | DERMATOLOGICALS ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. Anesthetics for topical use |
| ATC | N01BB06 | NERVOUS SYSTEM ANESTHETICS ANESTHETICS, LOCAL Amides |
| ATC | S01HA06 | SENSORY ORGANS OPHTHALMOLOGICALS LOCAL ANESTHETICS Local anesthetics |
| ATC | S02DA04 | SENSORY ORGANS OTOLOGICALS OTHER OTOLOGICALS Analgesics and anesthetics |
| FDA CS | M0000728 | Allergens |
| MeSH PA | D000777 | Anesthetics |
| MeSH PA | D000779 | Anesthetics, Local |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
| FDA PE | N0000175629 | Increased Histamine Release |
| FDA PE | N0000184306 | Cell-mediated Immunity |
| FDA EPC | N0000185508 | Standardized Chemical Allergen |
| CHEBI has role | CHEBI:48425 | topical anesthetic |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Skin irritation | indication | 367466007 | |
| Itching of skin | indication | 418363000 | |
| Minor Skin Wound Pain | indication | ||
| Conduction disorder of the heart | contraindication | 44808001 | |
| Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
| Bleeding hemorrhoids | contraindication | 51551000 | |
| Decreased respiratory function | contraindication | 80954004 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Myasthenia gravis | contraindication | 91637004 | DOID:437 |
| Disorder of mucous membrane | contraindication | 95351003 | |
| Open wound | contraindication | 125643001 | |
| Seizure disorder | contraindication | 128613002 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Deficiency of cholinesterase | contraindication | 360607009 | |
| Denuded skin | contraindication | 418242004 |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Dogs | Euthanasia | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Repose Euthanasia Solution | Zoetis Inc. | 2 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.24 | acidic |
| pKa2 | 9.02 | Basic |
| pKa3 | 3.84 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium channel protein type 5 subunit alpha | Ion channel | BLOCKER | DRUGBANK | CHEMBL | |||||
| Sodium channel protein type 10 subunit alpha | Ion channel | BLOCKER | DRUGBANK | CHEMBL | |||||
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | IC50 | 5.85 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018897 | VUID |
| N0000147191 | NUI |
| D00733 | KEGG_DRUG |
| 235402 | RXNORM |
| 4018897 | VANDF |
| C0012050 | UMLSCUI |
| CHEBI:247956 | CHEBI |
| CHEMBL1086 | ChEMBL_ID |
| CHEMBL1200612 | ChEMBL_ID |
| DB00527 | DRUGBANK_ID |
| 7159 | IUPHAR_LIGAND_ID |
| 61-12-1 | SECONDARY_CAS_RN |
| 3025 | PUBCHEM_CID |
| 14979 | MMSL |
| 4577 | MMSL |
| 5847 | MMSL |
| 73107 | MMSL |
| 001371 | NDDF |
| 001372 | NDDF |
| 349831001 | SNOMEDCT_US |
| 395953008 | SNOMEDCT_US |
| 39808001 | SNOMEDCT_US |
| D003992 | MESH_DESCRIPTOR_UI |
| 108 | INN_ID |
| L6JW2TJG99 | UNII |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| DIBUCAINE | HUMAN OTC DRUG LABEL | 1 | 0168-0046 | OINTMENT | 1 g | TOPICAL | OTC monograph final | 9 sections |
| Dibucaine Topical Anesthetic 1% Hemorrhoidal | HUMAN OTC DRUG LABEL | 1 | 0536-1211 | OINTMENT | 10 mg | TOPICAL | OTC monograph final | 14 sections |
| Precaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10866-0062 | GEL | 8 mg | BUCCAL | Export only | 6 sections |
| Precaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10866-0062 | GEL | 8 mg | BUCCAL | Export only | 6 sections |
| Precaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10866-0062 | GEL | 8 mg | BUCCAL | Export only | 6 sections |
| dibucaine | HUMAN OTC DRUG LABEL | 1 | 45802-050 | OINTMENT | 1 g | TOPICAL | OTC monograph final | 14 sections |
| Dibucaine | HUMAN OTC DRUG LABEL | 1 | 54162-011 | OINTMENT | 0.28 g | TOPICAL | OTC monograph final | 9 sections |
| Nupercainal | HUMAN OTC DRUG LABEL | 1 | 55741-402 | OINTMENT | 1 g | TOPICAL | OTC monograph final | 15 sections |
| Dibucaine | HUMAN OTC DRUG LABEL | 1 | 57896-131 | OINTMENT | 1 g | TOPICAL | OTC monograph final | 14 sections |
| DIBUCAINE | HUMAN OTC DRUG LABEL | 1 | 59779-398 | CREAM | 10 mg | TOPICAL | OTC monograph final | 7 sections |
| CVS Hemorrhoidal Topical Analgesic | HUMAN OTC DRUG LABEL | 1 | 59779-997 | OINTMENT | 10 mg | TOPICAL | OTC monograph final | 13 sections |
| Dibucaine | HUMAN OTC DRUG LABEL | 1 | 63868-911 | OINTMENT | 1 g | TOPICAL | OTC monograph final | 15 sections |
| Dibucaine | HUMAN OTC DRUG LABEL | 1 | 63868-911 | OINTMENT | 1 g | TOPICAL | OTC monograph final | 15 sections |
| Dibucaine | HUMAN OTC DRUG LABEL | 1 | 69396-023 | OINTMENT | 1 g | TOPICAL | OTC monograph final | 15 sections |
| Dibucaine | HUMAN OTC DRUG LABEL | 1 | 71399-2829 | OINTMENT | 0.28 g | TOPICAL | OTC monograph final | 9 sections |
| Dibucaine | HUMAN OTC DRUG LABEL | 1 | 71399-2829 | OINTMENT | 0.28 g | TOPICAL | OTC monograph final | 9 sections |
| DIBUCAINE HCL 0.5% / LIDOCAINE 15% / PHENYLEPHRINE HCL 1% / PRILOCAINE 5% | HUMAN PRESCRIPTION DRUG LABEL | 4 | 72934-5071 | OINTMENT | 0.50 g | TOPICAL | unapproved drug other | 4 sections |
| DIBUCAINE | HUMAN OTC DRUG LABEL | 1 | 81266-920 | OINTMENT | 0.01 g | TOPICAL | OTC monograph final | 15 sections |