dibenzepin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| tricyclic compounds | 856 | 4498-32-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.30 | g | O |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N06AA08 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Non-selective monoamine reuptake inhibitors |
| MeSH PA | D000928 | Antidepressive Agents |
| MeSH PA | D000929 | Antidepressive Agents, Tricyclic |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D011619 | Psychotropic Drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.1 | Basic |
| pKa2 | 6.19 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | GPCR | Ki | 4.52 | CHEMBL | |||||
| Sodium-dependent serotonin transporter | Transporter | Ki | 4.96 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 1A | GPCR | Ki | 5.60 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 2A | GPCR | Ki | 5.14 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 6 | GPCR | Ki | 5.48 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 7 | GPCR | Ki | 4.91 | CHEMBL | |||||
| Histamine H1 receptor | GPCR | Ki | 7.70 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01314 | KEGG_DRUG |
| 236807 | RXNORM |
| C0012029 | UMLSCUI |
| CHEBI:31476 | CHEBI |
| CHEMBL1442422 | ChEMBL_ID |
| DB13225 | DRUGBANK_ID |
| C084605 | MESH_SUPPLEMENTAL_RECORD_UI |
| 9419 | PUBCHEM_CID |
| 1738 | INN_ID |
| 315-80-0 | SECONDARY_CAS_RN |
| 510SJZ1Y6L | UNII |
| 006897 | NDDF |
| 006898 | NDDF |
| 32757009 | SNOMEDCT_US |
| CHEMBL2104287 | ChEMBL_ID |
| CHEMBL99486 | ChEMBL_ID |
Pharmaceutical products:
None