diazepam Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 852 439-14-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • RO-5-2807
  • diazepam
  • valium
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
  • Molecular weight: 284.74
  • Formula: C16H13ClN2O
  • CLOGP: 2.96
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 32.67
  • ALOGS: -4.37
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
10 mg P
10 mg R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.06 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.01 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.38 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 42 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 15, 1963 FDA ROCHE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 2489.10 9.94 1715 131346 63811 53152194
Toxicity to various agents 2101.94 9.94 2656 130405 216942 52999063
Completed suicide 1424.20 9.94 1737 131324 136464 53079541
Intentional overdose 1327.77 9.94 1197 131864 66008 53149997
Suicide attempt 982.74 9.94 950 132111 57218 53158787
Coma 650.29 9.94 786 132275 60997 53155008
Overdose 607.43 9.94 1017 132044 106719 53109286
Intentional self-injury 547.82 9.94 475 132586 24809 53191196
Respiratory arrest 519.98 9.94 523 132538 33017 53182988
Somnolence 516.24 9.94 1229 131832 166505 53049500
Rheumatoid arthritis 512.43 9.94 85 132976 314446 52901559
Drug dependence 460.33 9.94 401 132660 21071 53194934
Sopor 458.56 9.94 397 132664 20687 53195318
Drug withdrawal syndrome 447.32 9.94 444 132617 27578 53188427
Poisoning 413.89 9.94 314 132747 13536 53202469
Poisoning deliberate 407.24 9.94 260 132801 8453 53207552
Suicidal ideation 348.40 9.94 577 132484 59934 53156071
Intentional product misuse 325.57 9.94 501 132560 48891 53167114
Agitation 287.75 9.94 521 132540 58105 53157900
Cardiac arrest 279.81 9.94 679 132382 92988 53123017
Cardio-respiratory arrest 278.05 9.94 514 132547 58244 53157761
Respiratory depression 272.10 9.94 238 132823 12568 53203437
Depressed level of consciousness 263.68 9.94 481 132580 53947 53162058
Pemphigus 239.03 9.94 4 133057 104027 53111978
Aggression 238.29 9.94 293 132768 23110 53192895
Miosis 225.35 9.94 166 132895 6836 53209169
Infusion related reaction 224.86 9.94 56 133005 155901 53060104
Synovitis 220.03 9.94 12 133049 107881 53108124
Contraindicated product administered 219.74 9.94 37 133024 135592 53080413
Neuroleptic malignant syndrome 205.68 9.94 198 132863 11835 53204170
Withdrawal syndrome 205.20 9.94 247 132814 19054 53196951
Schizophrenia 200.44 9.94 182 132879 10097 53205908
Seizure 193.78 9.94 736 132325 128773 53087232
Psychotic disorder 193.42 9.94 270 132791 24115 53191890
Joint swelling 192.44 9.94 181 132880 234457 52981548
Anxiety 191.67 9.94 983 132078 195721 53020284
Drug interaction 189.89 9.94 1061 132000 218268 52997737
Systemic lupus erythematosus 188.77 9.94 41 133020 125373 53090632
Treatment failure 177.68 9.94 50 133011 128353 53087652
Serotonin syndrome 171.34 9.94 266 132795 26140 53189865
Bradypnoea 168.15 9.94 104 132957 3193 53212812
Disturbance in attention 166.65 9.94 304 132757 34079 53181926
Drug intolerance 160.97 9.94 165 132896 205328 53010677
Glossodynia 158.84 9.94 29 133032 100262 53115743
Rash 156.63 9.94 579 132482 445612 52770393
Drug ineffective 152.54 9.94 1307 131754 815938 52400067
Tremor 150.43 9.94 667 132394 125069 53090936
Therapeutic product effect decreased 144.82 9.94 66 132995 125589 53090416
Alopecia 142.70 9.94 228 132833 234355 52981650
Peripheral swelling 141.43 9.94 184 132877 205924 53010081
Arthropathy 140.12 9.94 90 132971 141363 53074642
Restlessness 138.23 9.94 250 132811 27837 53188168
Depression 132.33 9.94 845 132216 182207 53033798
Nightmare 131.11 9.94 190 132871 17561 53198444
Substance abuse 130.09 9.94 100 132961 4394 53211611
Swelling 128.66 9.94 173 132888 190932 53025073
Panic attack 128.26 9.94 208 132853 21210 53194795
Accidental overdose 126.46 9.94 207 132854 21272 53194733
Arthralgia 124.61 9.94 619 132442 439164 52776841
Diarrhoea 124.36 9.94 983 132078 624563 52591442
Pericarditis 122.96 9.94 10 133051 64396 53151609
Abdominal discomfort 122.42 9.94 228 132833 220834 52995171
Tachycardia 121.16 9.94 563 132498 107649 53108356
Sedation 120.00 9.94 243 132818 29432 53186573
Status epilepticus 117.25 9.94 166 132895 15018 53200987
Anaemia 117.18 9.94 330 132731 276388 52939617
Nasopharyngitis 114.00 9.94 190 132871 192105 53023900
Wound 112.03 9.94 44 133017 91513 53124492
Drug withdrawal convulsions 109.59 9.94 58 133003 1314 53214691
Bradyphrenia 107.75 9.94 107 132954 6643 53209362
Mydriasis 107.61 9.94 137 132924 11189 53204816
Sinusitis 106.11 9.94 160 132901 168404 53047601
Hypomania 104.23 9.94 91 132970 4791 53211214
Muscle rigidity 102.79 9.94 131 132930 10710 53205295
Febrile neutropenia 102.22 9.94 68 132993 104868 53111137
Hypersensitivity 100.86 9.94 236 132825 210429 53005576
Hand deformity 98.63 9.94 44 133017 84805 53131200
Dissociation 97.82 9.94 64 132997 2170 53213835
Infection 94.95 9.94 178 132883 172027 53043978
Cough 93.47 9.94 328 132733 256565 52959440
Off label use 90.90 9.94 748 132313 471464 52744541
Fatigue 90.11 9.94 1283 131778 729223 52486782
Asphyxia 89.52 9.94 91 132970 5810 53210195
Exposure via ingestion 88.94 9.94 70 132991 3185 53212820
Discomfort 88.84 9.94 65 132996 95407 53120598
Altered state of consciousness 88.34 9.94 193 132868 24643 53191362
Agoraphobia 86.00 9.94 34 133027 378 53215627
Dyspnoea 85.76 9.94 993 132068 585239 52630766
Hyperhidrosis 84.06 9.94 469 132592 96324 53119681
Stomatitis 83.60 9.94 73 132988 98085 53117920
Salivary hypersecretion 82.35 9.94 94 132967 6849 53209156
Urinary retention 79.23 9.94 201 132860 28265 53187740
Dyskinesia 78.65 9.94 215 132846 31618 53184387
Irritability 78.42 9.94 211 132850 30742 53185263
Pain 77.61 9.94 1019 132042 587379 52628626
Hypotonia 76.93 9.94 103 132958 8838 53207167
Extrapyramidal disorder 76.37 9.94 122 132939 12280 53203725
Thrombocytopenia 75.05 9.94 145 132916 138582 53077423
Helicobacter infection 74.75 9.94 6 133055 39063 53176942
Dysarthria 73.81 9.94 246 132815 40322 53175683
Therapeutic product effect incomplete 73.73 9.94 72 132989 91712 53124293
Derealisation 73.38 9.94 40 133021 963 53215042
Mania 72.35 9.94 116 132945 11713 53204292
Disease progression 71.90 9.94 89 132972 101831 53114174
General physical health deterioration 71.58 9.94 163 132898 146779 53069226
Dystonia 70.65 9.94 121 132940 12900 53203105
Disorientation 70.13 9.94 237 132824 39122 53176883
Loss of consciousness 69.18 9.94 505 132556 113707 53102298
Depersonalisation/derealisation disorder 68.77 9.94 41 133020 1176 53214829
Hypothermia 67.81 9.94 119 132942 12937 53203068
Feeling of despair 66.97 9.94 49 133012 1996 53214009
Accidental death 66.37 9.94 46 133015 1718 53214287
Coma scale abnormal 66.37 9.94 73 132988 5105 53210900
Mood swings 65.77 9.94 139 132922 17347 53198658
Abnormal behaviour 65.71 9.94 159 132902 21707 53194298
Emotional disorder 65.40 9.94 117 132944 12913 53203092
Akathisia 65.13 9.94 93 132968 8478 53207527
Cogwheel rigidity 64.99 9.94 45 133016 1678 53214327
Psychomotor hyperactivity 64.50 9.94 101 132960 9995 53206010
Jaundice cholestatic 64.08 9.94 74 132987 5460 53210545
Gastric pH decreased 64.07 9.94 31 133030 577 53215428
Tearfulness 60.84 9.94 63 132998 4111 53211894
Duodenal ulcer perforation 60.62 9.94 8 133053 35175 53180830
Generalised tonic-clonic seizure 60.18 9.94 183 132878 28575 53187430
Parkinsonism 60.14 9.94 92 132969 8921 53207084
Neutropenia 60.04 9.94 200 132861 158985 53057020
Hallucination, auditory 59.46 9.94 106 132955 11667 53204338
Respiratory acidosis 58.69 9.94 76 132985 6312 53209693
Drooling 58.58 9.94 57 133004 3451 53212554
Gastrointestinal disorder 57.01 9.94 85 132976 89919 53126086
Arthritis 56.71 9.94 81 132980 87217 53128788
Malignant neoplasm progression 56.44 9.94 57 133004 71484 53144521
Haemoglobin decreased 56.37 9.94 166 132895 137141 53078864
Stiff person syndrome 56.10 9.94 22 133039 239 53215766
Speech disorder 55.50 9.94 219 132842 38962 53177043
Acute kidney injury 53.44 9.94 392 132669 253476 52962529
Muscle injury 53.17 9.94 6 133055 29760 53186245
Interstitial lung disease 53.12 9.94 41 133020 58581 53157424
Pruritus 53.01 9.94 473 132588 293359 52922646
Dependence 52.04 9.94 43 133018 2098 53213907
Hallucination 51.55 9.94 268 132793 53570 53162435
Platelet count decreased 50.96 9.94 122 132939 107977 53108028
Unresponsive to stimuli 50.75 9.94 191 132870 33235 53182770
Anger 50.72 9.94 102 132959 12288 53203717
Ataxia 50.69 9.94 113 132948 14624 53201381
Drug abuser 50.36 9.94 50 133011 3103 53212902
Product use issue 50.18 9.94 179 132882 139405 53076600
C-reactive protein abnormal 49.42 9.94 4 133057 25866 53190139
Bone marrow failure 49.21 9.94 8 133053 30107 53185898
Mucosal inflammation 48.44 9.94 23 133038 42761 53173244
Multiple sclerosis relapse 48.42 9.94 231 132830 44622 53171383
Hallucinations, mixed 48.04 9.94 57 133004 4329 53211676
Self-injurious ideation 47.84 9.94 43 133018 2353 53213652
Lower respiratory tract infection 47.55 9.94 97 132964 90884 53125121
Gastrointestinal haemorrhage 46.05 9.94 81 132980 80249 53135756
Hepatic enzyme increased 45.24 9.94 162 132899 126033 53089972
Injection site pain 45.16 9.94 139 132922 113252 53102753
Lethargy 45.00 9.94 258 132803 53502 53162503
Confusional state 44.91 9.94 707 132354 193514 53022491
Depressed mood 44.82 9.94 197 132864 36767 53179238
Knee arthroplasty 44.71 9.94 14 133047 33555 53182450
Product dose omission issue 44.70 9.94 287 132774 191333 53024672
Snoring 44.40 9.94 51 133010 3741 53212264
Impaired healing 44.30 9.94 57 133004 64148 53151857
Victim of sexual abuse 43.58 9.94 23 133038 518 53215487
Reversible airways obstruction 43.44 9.94 30 133031 1114 53214891
Aspiration 42.93 9.94 85 132976 10125 53205880
Mental disorder 42.73 9.94 146 132915 24230 53191775
Victim of child abuse 42.57 9.94 10 133051 11 53215994
Visceral congestion 42.32 9.94 19 133042 296 53215709
Drowning 41.86 9.94 21 133040 424 53215581
Drug withdrawal syndrome neonatal 41.78 9.94 38 133023 2112 53213893
Feeling of body temperature change 41.31 9.94 54 133007 4526 53211479
Pleural effusion 40.93 9.94 101 132960 88478 53127527
Insomnia 40.64 9.94 674 132387 186398 53029607
Drug use disorder 40.60 9.94 45 133016 3174 53212831
Psychogenic seizure 40.25 9.94 34 133027 1711 53214294
Pneumonia aspiration 40.22 9.94 181 132880 34120 53181885
Catatonia 40.17 9.94 50 133011 3990 53212015
Myoglobin urine present 40.17 9.94 18 133043 279 53215726
Fluid retention 39.96 9.94 46 133015 54355 53161650
Physical assault 39.86 9.94 27 133034 971 53215034
Immobilisation prolonged 39.85 9.94 13 133048 78 53215927
H1N1 influenza 39.66 9.94 33 133028 1626 53214379
Psychomotor skills impaired 39.60 9.94 38 133023 2261 53213744
Pyrexia 39.54 9.94 738 132323 402455 52813550
Pancreatic fibrosis 38.90 9.94 13 133048 85 53215920
Rhesus incompatibility 38.90 9.94 13 133048 85 53215920
Vital capacity decreased 38.87 9.94 27 133034 1012 53214993
Oropharyngeal pain 38.87 9.94 91 132970 81177 53134828
Delirium 38.81 9.94 205 132856 41224 53174781
Device expulsion 38.70 9.94 13 133048 29800 53186205
Herpes zoster 38.60 9.94 79 132982 73940 53142065
Renal ischaemia 38.36 9.94 22 133039 586 53215419
Atrial fibrillation 38.27 9.94 146 132915 111506 53104499
Developmental delay 37.57 9.94 29 133032 1282 53214723
Cytomegalovirus infection 37.38 9.94 3 133058 19536 53196469
Urticaria 37.33 9.94 193 132868 135692 53080313
Neoplasm progression 37.21 9.94 14 133047 29905 53186100
Housebound 37.04 9.94 16 133045 226 53215779
Pancytopenia 36.53 9.94 111 132950 90817 53125188
Alcohol poisoning 36.25 9.94 33 133028 1836 53214169
Electrocardiogram QT prolonged 36.22 9.94 253 132808 56150 53159855
Vision blurred 36.07 9.94 349 132712 85255 53130750
Chemical submission 36.05 9.94 15 133046 192 53215813
Hypotonia neonatal 35.79 9.94 26 133035 1047 53214958
Delusion 35.73 9.94 87 132974 11922 53204083
Paranoia 35.32 9.94 84 132977 11340 53204665
Crying 35.29 9.94 129 132932 22133 53193872
PO2 increased 35.26 9.94 24 133037 870 53215135
Psoriasis 35.21 9.94 106 132955 86983 53129022
Muscle spasms 35.15 9.94 501 132560 134294 53081711
Right ventricular hypertrophy 34.92 9.94 22 133039 698 53215307
Pulmonary arterial hypertension 34.91 9.94 12 133049 27110 53188895
Hip arthroplasty 34.71 9.94 13 133048 27849 53188156
Pleurothotonus 34.16 9.94 28 133033 1351 53214654
Drug diversion 33.26 9.94 23 133038 856 53215149
Psychomotor retardation 32.98 9.94 43 133018 3595 53212410
Restless legs syndrome 32.72 9.94 106 132955 17117 53198888
Sleep disorder 32.63 9.94 255 132806 58615 53157390
Cardiac failure congestive 32.62 9.94 120 132941 92637 53123368
Blood creatine phosphokinase increased 32.54 9.94 151 132910 28834 53187171
Plasma cell myeloma 32.51 9.94 43 133018 47831 53168174
Blood creatinine increased 32.43 9.94 102 132959 82560 53133445
PCO2 increased 32.39 9.94 26 133035 1217 53214788
Drug screen positive 32.39 9.94 44 133017 3828 53212177
Multiple sclerosis 32.38 9.94 144 132917 27009 53188996
Hepatic necrosis 31.94 9.94 54 133007 5696 53210309
Loss of personal independence in daily activities 31.94 9.94 80 132981 69735 53146270
Mutism 31.50 9.94 27 133034 1386 53214619
Myocardial fibrosis 31.17 9.94 19 133042 568 53215437
Pyramidal tract syndrome 30.94 9.94 16 133045 345 53215660
Asthma 30.93 9.94 153 132908 108819 53107186
Right ventricular dilatation 30.90 9.94 23 133038 962 53215043
Cardiac failure 30.89 9.94 110 132951 85734 53130271
Myoclonus 30.83 9.94 98 132963 15666 53200339
Injection site pruritus 30.72 9.94 35 133026 41554 53174451
Inflammation 30.63 9.94 60 133001 57076 53158929
Drug level increased 30.43 9.94 116 132945 20305 53195700
Flashback 30.31 9.94 12 133049 134 53215871
Blood pH decreased 30.17 9.94 35 133026 2595 53213410
Sputum culture positive 30.15 9.94 27 133034 1470 53214535
Autonomic nervous system imbalance 30.12 9.94 35 133026 2599 53213406
Panic reaction 29.94 9.94 43 133018 3940 53212065
Bronchial secretion retention 29.87 9.94 28 133033 1618 53214387
Injection site reaction 29.86 9.94 51 133010 51115 53164890
Hypersomnia 29.58 9.94 99 132962 16256 53199749
Amnesia 29.58 9.94 204 132857 45084 53170921
Dyspnoea exertional 29.27 9.94 58 133003 54942 53161063
Injection site erythema 29.14 9.94 97 132964 77152 53138853
Erythema 29.00 9.94 251 132810 156718 53059287
Diabetes insipidus 28.92 9.94 34 133027 2557 53213448
Cyanosis 28.59 9.94 99 132962 16540 53199465
Memory impairment 28.42 9.94 330 132731 84427 53131578
Conversion disorder 28.29 9.94 28 133033 1731 53214274
Urine osmolarity increased 28.26 9.94 11 133050 117 53215888
Hyperkalaemia 28.21 9.94 58 133003 54198 53161807
Abdominal pain 28.05 9.94 459 132602 255444 52960561
Antipsychotic drug level increased 28.01 9.94 38 133023 3301 53212704
Sepsis 28.01 9.94 232 132829 146197 53069808
Paralysis 27.94 9.94 68 132993 9316 53206689
Blood pressure systolic increased 27.77 9.94 28 133033 35149 53180856
Posturing 27.63 9.94 17 133044 517 53215488
Balance disorder 27.26 9.94 291 132770 72916 53143089
Generalised anxiety disorder 27.04 9.94 29 133032 1971 53214034
Electroencephalogram abnormal 26.91 9.94 40 133021 3781 53212224
Nasal congestion 26.83 9.94 58 133003 53229 53162776
Wheezing 26.71 9.94 79 132982 65196 53150809
Autonomic dysreflexia 26.70 9.94 14 133047 311 53215694
Urine sodium increased 26.69 9.94 10 133051 95 53215910
Somnambulism 26.46 9.94 48 133013 5354 53210651
Paraesthesia 26.42 9.94 456 132605 127059 53088946
Alcohol use 26.35 9.94 29 133032 2029 53213976
Calcium deficiency 26.33 9.94 21 133040 974 53215031
Impaired reasoning 26.29 9.94 9 133052 64 53215941
Fluid overload 25.81 9.94 19 133042 27812 53188193
Somatic delusion 25.50 9.94 17 133044 595 53215410
Psoriatic arthropathy 25.49 9.94 51 133010 48139 53167866
Sensory loss 25.39 9.94 59 133002 7846 53208159
Hyperprolactinaemia 25.23 9.94 36 133025 3279 53212726
COVID-19 25.18 9.94 33 133028 36855 53179150
Epilepsy 25.17 9.94 129 132932 25638 53190367
Pain in extremity 25.11 9.94 531 132530 284519 52931486
C-reactive protein increased 25.09 9.94 86 132975 67800 53148205
Incontinence 24.99 9.94 71 132990 10672 53205333
Parosmia 24.95 9.94 43 133018 4607 53211398
Patient uncooperative 24.93 9.94 11 133050 164 53215841
Tissue infiltration 24.86 9.94 17 133044 621 53215384
Lactic acidosis 24.75 9.94 34 133027 37219 53178786
Treatment noncompliance 24.73 9.94 154 132907 32881 53183124
Respiratory rate decreased 24.66 9.94 36 133025 3348 53212657
Tardive dyskinesia 24.58 9.94 59 133002 8011 53207994
Hypokinesia 24.58 9.94 80 132981 12947 53203058
Upper respiratory tract infection 24.55 9.94 89 132972 69008 53146997
Productive cough 24.43 9.94 67 132994 56662 53159343
Suicidal behaviour 24.39 9.94 31 133030 2527 53213478
Bronchitis 24.37 9.94 171 132890 111728 53104277
Rhesus antigen positive 24.32 9.94 10 133051 124 53215881
Hypotension 24.14 9.94 816 132245 253260 52962745
Muscle disorder 24.11 9.94 42 133019 4539 53211466
Sudden death 24.10 9.94 68 132993 10180 53205825
Swollen tongue 23.97 9.94 146 132915 30934 53185071
Ill-defined disorder 23.93 9.94 55 133006 49389 53166616
Cortisol increased 23.63 9.94 14 133047 397 53215608
Negativism 23.47 9.94 14 133047 402 53215603
Social avoidant behaviour 23.39 9.94 33 133028 2975 53213030
Anticonvulsant drug level above therapeutic 23.37 9.94 15 133046 492 53215513
Pneumocystis jirovecii pneumonia 23.35 9.94 6 133055 16372 53199633
Blood osmolarity decreased 22.96 9.94 19 133042 929 53215076
Ductus arteriosus premature closure 22.88 9.94 13 133048 340 53215665
Aphasia 22.74 9.94 143 132918 30635 53185370
Hypoxic-ischaemic encephalopathy 22.69 9.94 39 133022 4169 53211836
Abnormal dreams 22.68 9.94 68 132993 10533 53205472
Feeling jittery 22.62 9.94 74 132987 12009 53203996
Sensory disturbance 22.42 9.94 77 132984 12809 53203196
Apathy 22.41 9.94 58 133003 8254 53207751
Ventricular dyskinesia 22.38 9.94 10 133051 154 53215851
Tooth hypoplasia 22.34 9.94 8 133053 66 53215939
Myelodysplastic syndrome 22.09 9.94 7 133054 16653 53199352
Blood pressure fluctuation 21.97 9.94 34 133027 35436 53180569
Pulmonary fibrosis 21.71 9.94 17 133044 24118 53191887
Asthenia 21.46 9.94 673 132388 342917 52873088
Apnoea 21.38 9.94 55 133006 7798 53208207
Bladder dilatation 21.21 9.94 17 133044 794 53215211
Basal ganglion degeneration 21.21 9.94 14 133047 482 53215523
Stupor 21.17 9.94 36 133025 3815 53212190
Thinking abnormal 21.17 9.94 66 132995 10442 53205563
Hospitalisation 21.14 9.94 98 132963 70914 53145091
Oropharyngeal oedema 21.11 9.94 11 133050 241 53215764
Ascites 21.06 9.94 42 133019 39693 53176312
Affective disorder 20.79 9.94 44 133017 5495 53210510
Hepatic steatosis 20.66 9.94 124 132937 26135 53189870
Suspected counterfeit product 20.65 9.94 12 133049 328 53215677
Nausea 20.57 9.94 1616 131445 754475 52461530
Logorrhoea 20.41 9.94 28 133033 2458 53213547
Renal failure 20.30 9.94 193 132868 118259 53097746
Hyperthermia 20.29 9.94 57 133004 8512 53207493
Colitis 20.29 9.94 46 133015 41506 53174499
Menstrual disorder 20.26 9.94 39 133022 4551 53211454
Osteonecrosis of jaw 20.21 9.94 37 133024 36109 53179896
Panic disorder 20.18 9.94 29 133032 2659 53213346
Abortion spontaneous 20.14 9.94 55 133006 46580 53169425
White blood cell count decreased 20.00 9.94 206 132855 124269 53091736
Cerebrospinal fluid leakage 19.98 9.94 18 133043 988 53215017
Irritable bowel syndrome 19.95 9.94 50 133011 43582 53172423
Fungal infection 19.88 9.94 31 133030 32215 53183790
Feeling drunk 19.86 9.94 36 133025 4013 53211992
Spleen congestion 19.66 9.94 9 133052 147 53215858
Bezoar 19.63 9.94 21 133040 1423 53214582
Blood immunoglobulin M decreased 19.62 9.94 16 133045 766 53215239
Neonatal complications of substance abuse 19.51 9.94 5 133056 10 53215995
Injection site swelling 19.38 9.94 49 133012 42579 53173426
Basal cell carcinoma 19.32 9.94 18 133043 23451 53192554
Electrocardiogram QRS complex shortened 19.30 9.94 13 133048 463 53215542
Thymus disorder 19.28 9.94 10 133051 217 53215788
Enterochromaffin cell hyperplasia 19.21 9.94 7 133054 61 53215944
Alpha 1 microglobulin increased 19.21 9.94 7 133054 61 53215944
Primitive reflex test positive 19.19 9.94 5 133056 11 53215994
Carcinoid tumour of the stomach 19.07 9.94 9 133052 158 53215847
Hypergastrinaemia 19.05 9.94 8 133053 105 53215900
Hallucination, visual 18.89 9.94 95 132966 18737 53197268
Road traffic accident 18.88 9.94 119 132942 25512 53190493
Behaviour disorder 18.81 9.94 27 133034 2473 53213532
Illogical thinking 18.73 9.94 7 133054 66 53215939
Defect conduction intraventricular 18.65 9.94 8 133053 111 53215894
Oral discomfort 18.62 9.94 56 133005 8690 53207315
Neuropathy peripheral 18.60 9.94 166 132895 103021 53112984
Movement disorder 18.57 9.94 94 132967 18587 53197418
Incoherent 18.57 9.94 38 133023 4634 53211371
Inadequate analgesia 18.54 9.94 29 133032 2866 53213139
Urinary incontinence 18.48 9.94 136 132925 30685 53185320
Palmar-plantar erythrodysaesthesia syndrome 18.47 9.94 16 133045 21590 53194415
Skin ulcer 18.45 9.94 39 133022 36080 53179925
Therapeutic response decreased 18.44 9.94 59 133002 47510 53168495
Emotional poverty 18.31 9.94 11 133050 320 53215685
Terminal dribbling 18.25 9.94 6 133055 37 53215968
Medication error 18.24 9.94 154 132907 36211 53179794
Borderline personality disorder 18.22 9.94 15 133046 728 53215277
Euphoric mood 18.20 9.94 37 133024 4492 53211513
Bone erosion 18.14 9.94 3 133058 11149 53204856
Pulmonary congestion 18.01 9.94 84 132977 16072 53199933
Liver function test increased 17.99 9.94 24 133037 26604 53189401
Melaena 17.96 9.94 28 133033 29101 53186904
Suspected suicide 17.93 9.94 36 133025 4332 53211673
Coordination abnormal 17.90 9.94 68 132993 11883 53204122
Dehydration 17.80 9.94 304 132757 168106 53047899
Somatic symptom disorder 17.79 9.94 24 133037 2074 53213931
Sinus tachycardia 17.71 9.94 110 132951 23462 53192543
Base excess 17.69 9.94 7 133054 78 53215927
Victim of chemical submission 17.69 9.94 10 133051 259 53215746
Gallbladder cholesterolosis 17.65 9.94 15 133046 761 53215244
Brain injury 17.58 9.94 45 133016 6360 53209645
Electrocardiogram QRS complex prolonged 17.51 9.94 42 133019 5700 53210305
Marchiafava-Bignami disease 17.40 9.94 5 133056 18 53215987
Influenza 17.39 9.94 153 132908 95226 53120779
Therapeutic product ineffective 17.36 9.94 18 133043 1176 53214829
Hyperacusis 17.34 9.94 23 133038 1955 53214050
Cardiac death 17.34 9.94 13 133048 550 53215455
Injection site bruising 17.32 9.94 43 133018 37603 53178402
Diastolic hypotension 17.30 9.94 7 133054 83 53215922
Hepatotoxicity 17.27 9.94 124 132937 27756 53188249
Leukopenia 17.12 9.94 110 132951 73353 53142652
Illness anxiety disorder 16.98 9.94 8 133053 140 53215865
Injection site warmth 16.93 9.94 7 133054 14121 53201884
Newborn persistent pulmonary hypertension 16.93 9.94 8 133053 141 53215864
Congenital central nervous system anomaly 16.89 9.94 11 133050 370 53215635
Sudden cardiac death 16.87 9.94 24 133037 2180 53213825
Pneumonia 16.83 9.94 837 132224 406332 52809673
Emotional distress 16.82 9.94 138 132923 32179 53183826
Periorbital swelling 16.81 9.94 21 133040 1682 53214323
Haematochezia 16.80 9.94 52 133009 42306 53173699
Cor pulmonale acute 16.78 9.94 11 133050 374 53215631
Distal intestinal obstruction syndrome 16.72 9.94 12 133049 474 53215531
Wrong rate 16.70 9.94 6 133055 50 53215955
Craniosynostosis 16.58 9.94 8 133053 148 53215857
Adverse drug reaction 16.56 9.94 73 132988 53552 53162453
Vestibular disorder 16.56 9.94 19 133042 1392 53214613
Clostridium difficile colitis 16.45 9.94 15 133046 19750 53196255
Acute myeloid leukaemia 16.44 9.94 11 133050 16921 53199084
Withdrawal catatonia 16.40 9.94 6 133055 53 53215952
Amylase increased 16.34 9.94 42 133019 5952 53210053
Obsessive-compulsive disorder 16.33 9.94 31 133030 3579 53212426
Cataract 16.28 9.94 66 132995 49554 53166451
Cholelithiasis 16.27 9.94 165 132896 40799 53175206
Neurosis 16.25 9.94 10 133051 304 53215701
Potentiating drug interaction 16.21 9.94 34 133027 4219 53211786
Intentional product use issue 16.16 9.94 110 132951 72384 53143621
Hemiparesis 16.00 9.94 100 132961 21375 53194630
Lack of spontaneous speech 15.84 9.94 8 133053 164 53215841
Oculogyric crisis 15.74 9.94 19 133042 1469 53214536
Disinhibition 15.72 9.94 15 133046 886 53215119
Personality disorder 15.72 9.94 33 133028 4098 53211907
Hypercapnic coma 15.70 9.94 8 133053 167 53215838
Neutrophil count decreased 15.68 9.94 66 132995 49032 53166973
Cyclothymic disorder 15.57 9.94 6 133055 62 53215943
Tenosynovitis 15.46 9.94 3 133058 9936 53206069
Foaming at mouth 15.43 9.94 17 133044 1191 53214814
Femur fracture 15.41 9.94 49 133012 39536 53176469
Toxicologic test abnormal 15.41 9.94 13 133048 653 53215352
Abdominal tenderness 15.32 9.94 49 133012 7858 53208147
Dyspraxia 15.26 9.94 9 133052 253 53215752
Accidental poisoning 15.22 9.94 13 133048 664 53215341
Gastrointestinal motility disorder 15.14 9.94 36 133025 4860 53211145
Poor sucking reflex 15.12 9.94 8 133053 181 53215824
Muscle tightness 15.12 9.94 61 133000 10960 53205045
Alcohol abuse 15.10 9.94 22 133039 2042 53213963
Benzodiazepine drug level increased 15.08 9.94 8 133053 182 53215823
Waxy flexibility 15.04 9.94 7 133054 119 53215886
Oedema 15.03 9.94 116 132945 74230 53141775
Sensation of foreign body 14.98 9.94 33 133028 4236 53211769
Atrioventricular septal defect 14.95 9.94 9 133052 263 53215742
Slow response to stimuli 14.93 9.94 15 133046 944 53215061
Thyroid adenoma 14.93 9.94 8 133053 186 53215819
Blood pressure diastolic decreased 14.91 9.94 12 133049 16791 53199214
Clonus 14.86 9.94 33 133028 4258 53211747
Psychiatric symptom 14.86 9.94 36 133025 4917 53211088
Tongue movement disturbance 14.85 9.94 9 133052 266 53215739
Lupus hepatitis 14.80 9.94 5 133056 34 53215971
Nodule 14.78 9.94 13 133048 17416 53198589
Clonic convulsion 14.72 9.94 13 133048 695 53215310
Gait deviation 14.69 9.94 6 133055 73 53215932
Tongue discolouration 14.68 9.94 27 133034 3043 53212962
Foetal death 14.68 9.94 54 133007 9293 53206712
Toxic encephalopathy 14.60 9.94 40 133021 5887 53210118
Adverse event 14.51 9.94 53 133008 41008 53174997
Tension 14.48 9.94 28 133033 3278 53212727
Epistaxis 14.47 9.94 106 132955 68604 53147401
Localised infection 14.36 9.94 28 133033 26688 53189317
Sputum discoloured 14.35 9.94 9 133052 14330 53201675
Clostridium difficile infection 14.34 9.94 30 133031 27863 53188142
Drug hypersensitivity 14.34 9.94 529 132532 264713 52951292
Rash pruritic 14.31 9.94 70 132991 49940 53166065
Hostility 14.30 9.94 19 133042 1618 53214387
Rhabdomyolysis 14.26 9.94 170 132891 43753 53172252
Facial nerve disorder 14.25 9.94 12 133049 601 53215404
Cellulitis 14.25 9.94 121 132940 75868 53140137
Infective pulmonary exacerbation of cystic fibrosis 14.24 9.94 5 133056 11151 53204854
Morbid thoughts 14.24 9.94 12 133049 602 53215403
Colitis ulcerative 14.21 9.94 19 133042 21042 53194963
Extravascular haemolysis 14.21 9.94 5 133056 39 53215966
Sinus bradycardia 14.19 9.94 73 132988 14528 53201477
Cholinergic syndrome 14.16 9.94 10 133051 385 53215620
Galactorrhoea 14.15 9.94 31 133030 3964 53212041
Drug-device interaction 14.14 9.94 6 133055 81 53215924
Blood bicarbonate decreased 14.10 9.94 26 133035 2936 53213069
Pain in jaw 14.04 9.94 53 133008 40616 53175389
Bundle branch block right 14.02 9.94 36 133025 5097 53210908
Needle track marks 14.00 9.94 4 133057 14 53215991
Mental impairment 13.96 9.94 68 132993 13241 53202764
Partial seizures 13.95 9.94 37 133024 5343 53210662
Blood sodium decreased 13.85 9.94 102 132959 23014 53192991
Perforation bile duct 13.79 9.94 4 133057 15 53215990
Renal impairment 13.75 9.94 137 132924 83181 53132824
Persistent depressive disorder 13.72 9.94 15 133046 1042 53214963
Judgement impaired 13.71 9.94 12 133049 634 53215371
Eosinophilia 13.65 9.94 20 133041 21315 53194690
Congenital hand malformation 13.55 9.94 9 133052 313 53215692
Hypoventilation 13.47 9.94 32 133029 4317 53211688
Uterine enlargement 13.45 9.94 16 133045 1218 53214787
Bruxism 13.36 9.94 27 133034 3264 53212741
Fear 13.36 9.94 79 132982 16562 53199443
Gastric lavage 13.30 9.94 5 133056 48 53215957
Kidney enlargement 13.25 9.94 11 133050 540 53215465
Abscess sterile 13.21 9.94 5 133056 49 53215956
Cardiac arrest neonatal 13.16 9.94 6 133055 97 53215908
Blood sodium increased 13.16 9.94 24 133037 2688 53213317
Rhinorrhoea 13.12 9.94 79 132982 53499 53162506
Anaesthesia 13.09 9.94 10 133051 435 53215570
Illusion 13.05 9.94 15 133046 1101 53214904
Delirium tremens 13.00 9.94 6 133055 100 53215905
Red blood cell sedimentation rate increased 12.95 9.94 32 133029 28025 53187980
Metastases to liver 12.94 9.94 21 133040 21475 53194530
Exposure to unspecified agent 12.92 9.94 3 133058 3 53216002
Formication 12.90 9.94 30 133031 3991 53212014
Porphyria 12.90 9.94 7 133054 167 53215838
Radial nerve palsy 12.90 9.94 10 133051 445 53215560
Obstructive airways disorder 12.89 9.94 81 132980 17348 53198657
Apgar score low 12.76 9.94 12 133049 696 53215309
Delusion of reference 12.73 9.94 6 133055 105 53215900
Adrenal insufficiency 12.65 9.94 11 133050 14818 53201187
Tinnitus 12.64 9.94 124 132937 30395 53185610
Encephalopathy 12.64 9.94 144 132917 36664 53179341
Septic shock 12.63 9.94 97 132964 62132 53153873
Choreoathetosis 12.59 9.94 10 133051 461 53215544
Lactate pyruvate ratio increased 12.58 9.94 6 133055 108 53215897
Head titubation 12.52 9.94 12 133049 713 53215292
Tuberculosis 12.46 9.94 6 133055 11065 53204940
Alcohol interaction 12.45 9.94 19 133042 1838 53214167
Feeling abnormal 12.44 9.94 433 132628 134868 53081137
Fibromyalgia 12.43 9.94 62 132999 44013 53171992
Frontotemporal dementia 12.37 9.94 8 133053 266 53215739
Pallor 12.29 9.94 106 132955 25076 53190929
Body temperature decreased 12.27 9.94 14 133047 16613 53199392
Nystagmus 12.24 9.94 38 133023 5998 53210007
Oxygen saturation abnormal 12.24 9.94 24 133037 2838 53213167
Ovarian cyst 12.23 9.94 12 133049 15257 53200748
Dysphagia 12.18 9.94 286 132775 84111 53131894
Hyperchloraemia 12.18 9.94 12 133049 738 53215267
Purpura senile 12.10 9.94 11 133050 611 53215394
Eye irritation 12.09 9.94 17 133044 18432 53197573
Victim of homicide 12.09 9.94 5 133056 63 53215942
Paradoxical drug reaction 12.00 9.94 26 133035 3299 53212706
Angioedema 11.98 9.94 59 133002 42017 53173988
Brain oedema 11.96 9.94 66 132995 13492 53202513
Muscle twitching 11.94 9.94 76 132985 16350 53199655
Intellectual disability 11.92 9.94 12 133049 757 53215248
Poor quality sleep 11.89 9.94 79 132982 17244 53198761
Reticulocytosis 11.88 9.94 6 133055 123 53215882
Poor venous access 11.86 9.94 5 133056 9970 53206035
Peritoneal perforation 11.83 9.94 6 133055 124 53215881
Eczema eyelids 11.79 9.94 6 133055 125 53215880
Antipsychotic drug level decreased 11.77 9.94 7 133054 200 53215805
Vertigo 11.76 9.94 201 132860 55880 53160125
Congenital nystagmus 11.71 9.94 3 133058 6 53215999
Hypertonia 11.70 9.94 32 133029 4705 53211300
Chronic kidney disease 11.67 9.94 62 132999 43308 53172697
Osteoporosis 11.64 9.94 68 132993 46392 53169613
Hypotensive crisis 11.62 9.94 4 133057 29 53215976
Hyperventilation 11.62 9.94 38 133023 6166 53209839
Skin reaction 11.60 9.94 8 133053 12115 53203890
Nervous system disorder 11.60 9.94 79 132982 17385 53198620
Inappropriate schedule of product administration 11.59 9.94 125 132936 74753 53141252
Bacteraemia 11.58 9.94 13 133048 15536 53200469
Right ventricular failure 11.56 9.94 15 133046 16828 53199177
Moaning 11.56 9.94 12 133049 785 53215220
Implant site extravasation 11.54 9.94 10 133051 521 53215484
Trismus 11.51 9.94 27 133034 3613 53212392
Progressive supranuclear palsy 11.49 9.94 5 133056 72 53215933
Gaze palsy 11.45 9.94 16 133045 1429 53214576
Product use in unapproved indication 11.44 9.94 204 132857 112085 53103920
Central nervous system stimulation 11.39 9.94 4 133057 31 53215974
Regressive behaviour 11.37 9.94 5 133056 74 53215931
Haemodynamic instability 11.34 9.94 47 133014 8547 53207458
Thrombosis 11.31 9.94 97 132964 60696 53155309
Body mass index decreased 11.24 9.94 9 133052 420 53215585
Uveitis 11.20 9.94 5 133056 9639 53206366
Blood citric acid increased 11.19 9.94 5 133056 77 53215928
Maternal exposure during pregnancy 11.17 9.94 299 132762 155340 53060665
Alcoholism 11.15 9.94 20 133041 2211 53213794
Resorption bone increased 11.14 9.94 14 133047 1128 53214877
Foetal exposure during pregnancy 11.11 9.94 134 132927 34581 53181424
Unmasking of previously unidentified disease 11.10 9.94 12 133049 823 53215182
Device difficult to use 11.08 9.94 6 133055 10353 53205652
Troponin increased 11.01 9.94 47 133014 8658 53207347
Brief psychotic disorder with marked stressors 10.96 9.94 5 133056 81 53215924
Neurological decompensation 10.78 9.94 21 133040 2471 53213534
Musculoskeletal stiffness 10.78 9.94 230 132831 123138 53092867
Mobility decreased 10.75 9.94 130 132931 76141 53139864
Thrombotic microangiopathy 10.60 9.94 5 133056 9332 53206673
Otospondylomegaepiphyseal dysplasia 10.59 9.94 5 133056 88 53215917
Hereditary angioedema 10.56 9.94 37 133024 6216 53209789
Pupil fixed 10.54 9.94 17 133044 1725 53214280
Camptocormia 10.54 9.94 8 133053 345 53215660
Breathing-related sleep disorder 10.53 9.94 5 133056 89 53215916
Duodenal ulcer 10.50 9.94 3 133058 7633 53208372
Aspartate aminotransferase increased 10.46 9.94 147 132914 83882 53132123
Anaphylactic reaction 10.43 9.94 94 132967 58232 53157773
Major depression 10.43 9.94 42 133019 7540 53208465
Myofascial pain syndrome 10.42 9.94 19 133042 2127 53213878
Acute myocardial infarction 10.41 9.94 45 133016 33190 53182815
Hyperglycaemia 10.40 9.94 58 133003 40026 53175979
Oromandibular dystonia 10.35 9.94 9 133052 471 53215534
Substance use 10.35 9.94 9 133052 471 53215534
Ventricular arrhythmia 10.34 9.94 26 133035 3634 53212371
Hyperchromic anaemia 10.32 9.94 4 133057 42 53215963
Hip fracture 10.30 9.94 36 133025 28221 53187784
Poverty of speech 10.26 9.94 8 133053 359 53215646
Muscle contractions involuntary 10.25 9.94 19 133042 2154 53213851
Rectal haemorrhage 10.24 9.94 61 133000 41420 53174585
Haemophagocytic lymphohistiocytosis 10.21 9.94 5 133056 9132 53206873
Hyporeflexia 10.21 9.94 18 133043 1964 53214041
Arteriosclerosis coronary artery 10.20 9.94 45 133016 8409 53207596
Anticonvulsant drug level increased 10.19 9.94 15 133046 1405 53214600
Prescription drug used without a prescription 10.17 9.94 17 133044 1777 53214228
Psychotic symptom 10.13 9.94 13 133048 1070 53214935
Areflexia 10.13 9.94 23 133038 3013 53212992
Automatic bladder 10.10 9.94 5 133056 98 53215907
Substance use disorder 10.10 9.94 5 133056 98 53215907
Decreased interest 10.05 9.94 24 133037 3249 53212756
Blood albumin increased 10.00 9.94 12 133049 922 53215083
Labelled drug-food interaction issue 10.00 9.94 3 133058 13 53215992
Food allergy 9.96 9.94 4 133057 8214 53207791
Haemoperitoneum 9.96 9.94 21 133040 2616 53213389
Change in seizure presentation 9.95 9.94 7 133054 268 53215737

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 3722.83 10.70 2512 91856 77731 32341427
Toxicity to various agents 3477.33 10.70 3353 91015 174688 32244470
Overdose 890.97 10.70 1177 93191 85900 32333258
Coma 864.99 10.70 824 93544 41788 32377370
Completed suicide 757.67 10.70 1124 93244 91393 32327765
Intentional overdose 750.00 10.70 754 93614 40847 32378311
Drug dependence 714.31 10.70 572 93796 22912 32396246
Poisoning 651.23 10.70 405 93963 10753 32408405
Somnolence 546.50 10.70 1035 93333 102762 32316396
Respiratory arrest 539.27 10.70 534 93834 28374 32390784
Suicide attempt 523.02 10.70 599 93769 37645 32381513
Intentional product misuse 486.80 10.70 561 93807 35490 32383668
Substance abuse 384.66 10.70 246 94122 6861 32412297
Accidental overdose 347.18 10.70 350 94018 18989 32400169
Aggression 339.67 10.70 491 93877 38898 32380260
Miosis 310.15 10.70 233 94135 8471 32410687
Poisoning deliberate 306.73 10.70 205 94163 6170 32412988
Respiratory depression 305.44 10.70 275 94093 12936 32406222
Agitation 298.51 10.70 569 93799 56667 32362491
Drug withdrawal syndrome 266.50 10.70 311 94057 19920 32399238
Intentional self-injury 237.50 10.70 245 94123 13655 32405503
Cardio-respiratory arrest 230.73 10.70 505 93863 55484 32363674
Diarrhoea 223.17 10.70 453 93915 364349 32054809
Sedation 216.49 10.70 268 94100 18258 32400900
Suicidal ideation 216.48 10.70 393 93975 37690 32381468
Bradypnoea 216.24 10.70 117 94251 2369 32416789
Sopor 209.65 10.70 212 94156 11537 32407621
Febrile neutropenia 208.56 10.70 46 94322 119520 32299638
Cardiac arrest 200.30 10.70 677 93691 96099 32323059
Depressed level of consciousness 199.35 10.70 395 93973 40452 32378706
Pneumonia aspiration 197.26 10.70 395 93973 40761 32378397
Asphyxia 173.51 10.70 138 94230 5462 32413696
Withdrawal syndrome 160.70 10.70 187 94181 11935 32407223
Neuroleptic malignant syndrome 159.40 10.70 224 94144 17271 32401887
Drug abuser 151.25 10.70 113 94255 4071 32415087
Drug interaction 150.28 10.70 1115 93253 217070 32202088
Drug use disorder 142.65 10.70 103 94265 3518 32415640
Anaemia 141.25 10.70 272 94096 223352 32195806
Anxiety 140.16 10.70 601 93767 95404 32323754
Restlessness 139.10 10.70 255 94113 24626 32394532
Bradyphrenia 136.88 10.70 111 94257 4518 32414640
Dysarthria 135.01 10.70 298 94070 32903 32386255
Acute kidney injury 134.38 10.70 422 93946 293046 32126112
Psychotic disorder 127.52 10.70 235 94133 22785 32396373
Pneumonia 126.77 10.70 566 93802 354686 32064472
Coma scale abnormal 124.56 10.70 95 94273 3532 32415626
Seizure 117.02 10.70 603 93765 103251 32315907
Housebound 115.94 10.70 38 94330 194 32418964
Rash 115.17 10.70 275 94093 209058 32210100
Dyspnoea 113.98 10.70 603 93765 361442 32057716
Prescription drug used without a prescription 111.90 10.70 61 94307 1254 32417904
Visceral congestion 110.86 10.70 46 94322 496 32418662
Logorrhoea 108.49 10.70 75 94293 2387 32416771
Accidental death 107.10 10.70 71 94297 2106 32417052
Malignant neoplasm progression 106.82 10.70 47 94321 78449 32340709
Salivary hypersecretion 102.59 10.70 122 94246 7966 32411192
Altered state of consciousness 100.44 10.70 207 94161 21790 32397368
Abnormal behaviour 100.28 10.70 231 94137 26235 32392923
Loss of consciousness 97.89 10.70 487 93881 82220 32336938
Thrombocytopenia 95.59 10.70 178 94190 148121 32271037
Sepsis 91.86 10.70 203 94165 158631 32260527
Extrapyramidal disorder 90.58 10.70 140 94228 11755 32407403
Delirium 89.96 10.70 307 94061 43739 32375419
Pancytopenia 89.23 10.70 80 94288 91155 32328003
Cardiac failure congestive 87.13 10.70 71 94297 84781 32334377
Atrial fibrillation 86.40 10.70 128 94240 116576 32302582
Drug screen positive 85.84 10.70 82 94286 4159 32414999
Interstitial lung disease 85.20 10.70 41 94327 64960 32354198
Disease progression 83.95 10.70 77 94291 86785 32332373
Cough 83.93 10.70 173 94195 138644 32280514
Disturbance in attention 82.05 10.70 200 94168 23553 32395605
Fatigue 81.68 10.70 640 93728 350061 32069097
Nausea 80.66 10.70 573 93795 320276 32098882
Brain oedema 80.35 10.70 139 94229 12821 32406337
Hypothermia 75.66 10.70 118 94250 9985 32409173
Dystonia 75.31 10.70 121 94247 10502 32408656
Alcohol poisoning 75.07 10.70 68 94300 3221 32415937
Pulmonary congestion 74.73 10.70 136 94232 13055 32406103
Arthralgia 74.61 10.70 204 94164 148244 32270914
Pyrexia 74.42 10.70 584 93784 319384 32099774
Confusional state 73.42 10.70 685 93683 142430 32276728
Mydriasis 73.27 10.70 92 94276 6354 32412804
Suicidal behaviour 72.43 10.70 48 94320 1423 32417735
Rheumatoid arthritis 72.02 10.70 20 94348 44524 32374634
Alcohol abuse 71.32 10.70 76 94292 4396 32414762
Delusion 69.06 10.70 131 94237 12977 32406181
Status epilepticus 68.29 10.70 124 94244 11882 32407276
Plasma cell myeloma 67.27 10.70 42 94326 57572 32361586
Off label use 65.33 10.70 572 93796 305748 32113410
Exposure via ingestion 64.42 10.70 54 94314 2303 32416855
Thinking abnormal 63.38 10.70 80 94288 5555 32413603
Electrocardiogram QT prolonged 63.10 10.70 255 94113 39386 32379772
Mood swings 62.03 10.70 96 94272 8069 32411089
Bradykinesia 61.67 10.70 69 94299 4217 32414941
Pulmonary oedema 61.63 10.70 282 94086 45985 32373173
Disorientation 61.38 10.70 225 94143 33200 32385958
Haemoglobin decreased 61.20 10.70 163 94205 119508 32299650
Peripheral swelling 58.73 10.70 67 94301 68278 32350880
Platelet count decreased 58.66 10.70 156 94212 114435 32304723
Irritability 58.59 10.70 181 94187 24473 32394685
COVID-19 58.48 10.70 11 94357 32004 32387154
Schizophrenia 57.91 10.70 104 94264 9880 32409278
Infusion related reaction 57.88 10.70 30 94338 45569 32373589
General physical health deterioration 57.43 10.70 159 94209 115100 32304058
Drug withdrawal convulsions 57.09 10.70 38 94330 1135 32418023
Renal impairment 56.07 10.70 114 94254 91858 32327300
Abdominal pain 55.66 10.70 234 94134 149295 32269863
Anger 55.48 10.70 113 94255 11791 32407367
Joint swelling 54.71 10.70 42 94326 51693 32367465
Aspiration 54.06 10.70 108 94260 11115 32408043
Echolalia 53.96 10.70 22 94346 226 32418932
Antipsychotic drug level increased 52.59 10.70 58 94310 3488 32415670
Akathisia 52.53 10.70 82 94286 6943 32412215
Psychomotor hyperactivity 52.22 10.70 94 94274 8945 32410213
Paranoia 52.11 10.70 104 94264 10695 32408463
Dyspnoea exertional 51.92 10.70 24 94344 38937 32380221
Weight decreased 51.91 10.70 274 94094 164544 32254614
Panic attack 51.84 10.70 95 94273 9166 32409992
Alcohol interaction 51.61 10.70 47 94321 2242 32416916
Product dose omission issue 51.47 10.70 141 94227 102434 32316724
Mental impairment 51.44 10.70 99 94269 9913 32409245
Decreased appetite 51.39 10.70 266 94102 160547 32258611
Depression 50.94 10.70 467 93901 96593 32322565
Pleural effusion 50.67 10.70 95 94273 78897 32340261
Cytomegalovirus infection 50.43 10.70 7 94361 25457 32393701
Generalised tonic-clonic seizure 50.42 10.70 153 94215 20486 32398672
Postmortem blood drug level abnormal 49.60 10.70 21 94347 239 32418919
International normalised ratio increased 49.12 10.70 42 94326 48993 32370165
Pruritus 48.14 10.70 201 94167 128501 32290657
Sudden death 48.09 10.70 129 94239 16103 32403055
Dehydration 47.86 10.70 202 94166 128756 32290402
Insomnia 47.79 10.70 473 93895 99875 32319283
Toxicologic test abnormal 47.62 10.70 26 94342 536 32418622
Oedema peripheral 47.27 10.70 171 94197 113920 32305238
Tremor 46.74 10.70 399 93969 80878 32338280
Nystagmus 45.92 10.70 62 94306 4600 32414558
Self-injurious ideation 45.83 10.70 38 94330 1596 32417562
Psychotic behaviour 45.50 10.70 27 94341 656 32418502
Mucosal inflammation 45.48 10.70 20 94348 33414 32385744
Infection 45.12 10.70 113 94255 84602 32334556
Tachycardia 44.82 10.70 387 93981 78701 32340457
Memory impairment 44.78 10.70 234 94134 40245 32378913
Cerebrovascular accident 43.79 10.70 118 94250 86202 32332956
Hallucination, auditory 43.29 10.70 94 94274 10256 32408902
Serotonin syndrome 43.26 10.70 138 94230 18979 32400179
Asthenia 43.25 10.70 457 93911 235487 32183671
Gastrointestinal haemorrhage 43.15 10.70 120 94248 86762 32332396
Cardiac failure 43.06 10.70 130 94238 91543 32327615
Psychotic symptom 42.95 10.70 35 94333 1434 32417724
Coordination abnormal 42.77 10.70 79 94289 7669 32411489
Renal failure 42.07 10.70 224 94144 134254 32284904
Ascites 42.02 10.70 33 94335 40158 32379000
Epilepsy 41.57 10.70 150 94218 21959 32397199
Nasopharyngitis 41.53 10.70 76 94292 63711 32355447
Stomatitis 40.85 10.70 34 94334 40195 32378963
Self-medication 40.71 10.70 42 94326 2339 32416819
Myocardial infarction 40.63 10.70 207 94161 125469 32293689
Epistaxis 40.58 10.70 62 94306 55793 32363365
Nightmare 40.39 10.70 106 94262 13060 32406098
Tension 39.59 10.70 40 94328 2173 32416985
Prostate cancer 39.54 10.70 15 94353 27391 32391767
Pneumonitis 39.48 10.70 19 94349 30115 32389043
Arteriosclerosis coronary artery 38.86 10.70 98 94270 11783 32407375
Emotional disorder 38.60 10.70 62 94306 5379 32413779
Hypertonia 38.58 10.70 58 94310 4751 32414407
Drug diversion 38.54 10.70 27 94341 878 32418280
Catatonia 38.08 10.70 57 94311 4651 32414507
Neutropenia 38.01 10.70 249 94119 141926 32277232
Colitis 37.93 10.70 26 94342 33925 32385233
Pneumocystis jirovecii pneumonia 37.81 10.70 5 94363 18865 32400293
Sinus tachycardia 37.61 10.70 119 94249 16295 32402863
Drug withdrawal syndrome neonatal 37.57 10.70 49 94319 3515 32415643
Product use in unapproved indication 37.24 10.70 129 94239 87075 32332083
Acute myeloid leukaemia 36.30 10.70 6 94362 19168 32399990
Hyperhidrosis 36.10 10.70 340 94028 70828 32348330
Hypotonia 35.86 10.70 73 94295 7614 32411544
Chills 35.76 10.70 112 94256 77972 32341186
Drug intolerance 35.31 10.70 57 94311 50178 32368980
Rhabdomyolysis 34.94 10.70 323 94045 66942 32352216
Asthma 34.89 10.70 46 94322 44019 32375139
Haematuria 34.82 10.70 54 94314 48307 32370851
Erythema 34.11 10.70 125 94243 82980 32336178
Behaviour disorder 33.89 10.70 47 94321 3577 32415581
Unresponsive to stimuli 33.62 10.70 164 94204 27445 32391713
Ataxia 33.54 10.70 97 94271 12644 32406514
Drug ineffective 33.42 10.70 853 93515 382624 32036534
Fluid overload 33.26 10.70 8 94360 19613 32399545
Haematochezia 33.06 10.70 39 94329 39169 32379989
Psoriasis 32.73 10.70 52 94316 46071 32373087
Hypoxic-ischaemic encephalopathy 32.65 10.70 54 94314 4800 32414358
Homicide 32.34 10.70 25 94343 948 32418210
Vestibular disorder 31.81 10.70 26 94342 1070 32418088
Angioedema 31.79 10.70 35 94333 36254 32382904
Acute myocardial infarction 31.39 10.70 71 94297 55078 32364080
Poor quality sleep 31.15 10.70 71 94297 8003 32411155
Mental disorder 31.09 10.70 103 94265 14445 32404713
Psychomotor skills impaired 30.50 10.70 37 94331 2466 32416692
Encephalitis toxic 30.38 10.70 15 94353 249 32418909
Agoraphobia 30.01 10.70 15 94353 256 32418902
Hypoventilation 29.24 10.70 42 94326 3302 32415856
Blood pressure fluctuation 29.08 10.70 11 94357 20124 32399034
Bronchopulmonary aspergillosis 28.98 10.70 3 94365 13684 32405474
Pupillary disorder 28.90 10.70 15 94353 278 32418880
Myelodysplastic syndrome 28.85 10.70 11 94357 20027 32399131
Amnesia 28.56 10.70 146 94222 24890 32394268
Blood creatinine increased 28.47 10.70 163 94205 95969 32323189
Sleep disorder 28.45 10.70 153 94215 26599 32392559
Anterograde amnesia 28.06 10.70 13 94355 186 32418972
Parkinsonism 27.96 10.70 67 94301 7802 32411356
Cerebral haemorrhage 27.79 10.70 36 94332 34711 32384447
Victim of chemical submission 27.61 10.70 9 94359 45 32419113
Palmar-plantar erythrodysaesthesia syndrome 27.54 10.70 6 94362 15743 32403415
Chest discomfort 27.52 10.70 66 94302 50164 32368994
Acute psychosis 27.47 10.70 31 94337 1912 32417246
Facial spasm 27.45 10.70 13 94355 196 32418962
Opiates positive 27.35 10.70 17 94351 450 32418708
Blood pressure increased 27.18 10.70 128 94240 79226 32339932
Brain injury 27.16 10.70 56 94312 5894 32413264
Bladder dilatation 27.05 10.70 27 94341 1445 32417713
Cerebral congestion 27.03 10.70 8 94360 27 32419131
Bone marrow failure 26.99 10.70 29 94339 30375 32388783
Dizziness 26.95 10.70 437 93931 209181 32209977
Clostridium difficile infection 26.94 10.70 9 94359 17787 32401371
Postmortem blood drug level increased 26.93 10.70 13 94355 205 32418953
Muscle spasticity 26.93 10.70 55 94313 5750 32413408
Chronic kidney disease 26.58 10.70 47 94321 39928 32379230
Inadequate analgesia 26.57 10.70 37 94331 2826 32416332
Tumour lysis syndrome 26.56 10.70 5 94363 14542 32404616
Productive cough 25.62 10.70 37 94331 34079 32385079
Blepharospasm 25.47 10.70 23 94345 1085 32418073
Anaphylactic reaction 25.45 10.70 30 94338 30142 32389016
Homicidal ideation 25.42 10.70 35 94333 2645 32416513
Oral discharge 25.39 10.70 11 94357 133 32419025
Neuropathy peripheral 25.31 10.70 126 94242 76856 32342302
Accident 25.27 10.70 44 94324 4078 32415080
Osteonecrosis of jaw 25.23 10.70 12 94356 19154 32400004
Electroencephalogram abnormal 24.98 10.70 34 94334 2542 32416616
Dependence 24.93 10.70 24 94344 1229 32417929
Victim of crime 24.90 10.70 15 94353 375 32418783
Suicide threat 24.79 10.70 7 94361 19 32419139
Sexual abuse 24.75 10.70 11 94357 142 32419016
Muscle rigidity 24.62 10.70 80 94288 11106 32408052
Nervousness 24.60 10.70 86 94282 12393 32406765
Necrotising colitis 24.34 10.70 22 94346 1039 32418119
Pruritus genital 23.50 10.70 17 94351 582 32418576
Spleen congestion 23.38 10.70 14 94354 346 32418812
Fatty liver alcoholic 23.22 10.70 9 94359 80 32419078
Stereotypy 23.07 10.70 18 94350 692 32418466
Urticaria 22.95 10.70 92 94276 59522 32359636
Persecutory delusion 22.87 10.70 31 94337 2308 32416850
Needle track marks 22.51 10.70 6 94362 12 32419146
Depressed mood 22.49 10.70 109 94259 18191 32400967
Herpes zoster 22.44 10.70 37 94331 32304 32386854
Patient restraint 22.38 10.70 9 94359 89 32419069
Mania 22.22 10.70 70 94298 9562 32409596
Basilar migraine 22.19 10.70 6 94362 13 32419145
Stiff person syndrome 22.17 10.70 10 94358 134 32419024
Neutrophil count increased 22.02 10.70 99 94269 16015 32403143
Injection site pain 21.86 10.70 39 94329 33019 32386139
Affect lability 21.83 10.70 39 94329 3689 32415469
Pulmonary fibrosis 21.78 10.70 11 94357 16963 32402195
White blood cell count decreased 21.76 10.70 165 94203 91033 32328125
Fluid retention 21.76 10.70 27 94341 26523 32392635
Penis injury 21.70 10.70 12 94356 254 32418904
Personal relationship issue 21.61 10.70 12 94356 256 32418902
Reflexes abnormal 21.61 10.70 13 94355 324 32418834
Hypocalcaemia 21.59 10.70 21 94347 23033 32396125
Crystalluria 21.54 10.70 15 94353 483 32418675
Hypomagnesaemia 21.54 10.70 14 94354 18791 32400367
Impaired self-care 21.51 10.70 21 94347 1094 32418064
Thrombosis 21.38 10.70 65 94303 45689 32373469
Electrolyte imbalance 21.28 10.70 5 94363 12457 32406701
Blood pressure systolic increased 21.26 10.70 12 94356 17384 32401774
Libido disorder 21.20 10.70 12 94356 266 32418892
Hospitalisation 21.19 10.70 72 94296 48899 32370259
Pancreatitis 21.00 10.70 50 94318 38101 32381057
Treatment noncompliance 20.92 10.70 143 94225 27059 32392099
Coronary artery disease 20.89 10.70 74 94294 49632 32369526
Diet refusal 20.82 10.70 13 94355 347 32418811
Inappropriate schedule of product administration 20.78 10.70 66 94302 45759 32373399
Pain in extremity 20.65 10.70 233 94135 118668 32300490
Osmolar gap abnormal 20.56 10.70 7 94361 41 32419117
Tubulointerstitial nephritis 20.55 10.70 16 94352 19561 32399597
Colitis ulcerative 20.49 10.70 12 94356 17039 32402119
Abnormal dreams 20.46 10.70 63 94305 8501 32410657
Bacteraemia 20.37 10.70 13 94355 17620 32401538
Hyperkalaemia 20.25 10.70 119 94249 69631 32349527
Melaena 20.24 10.70 44 94324 34621 32384537
Cytokine release syndrome 20.22 10.70 7 94361 13528 32405630
Rash pruritic 20.20 10.70 25 94343 24586 32394572
Opisthotonus 20.15 10.70 14 94354 449 32418709
Medication error 20.11 10.70 123 94245 22412 32396746
Accidental poisoning 19.80 10.70 15 94353 552 32418606
Portal tract inflammation 19.72 10.70 8 94360 81 32419077
Persistent depressive disorder 19.60 10.70 12 94356 309 32418849
Road traffic accident 19.57 10.70 101 94267 17280 32401878
Treatment failure 19.50 10.70 54 94314 39109 32380049
Peritonitis bacterial 19.48 10.70 6 94362 12490 32406668
Respiratory acidosis 19.42 10.70 41 94327 4387 32414771
Cardiomegaly 19.42 10.70 91 94277 14980 32404178
Drug detoxification 19.39 10.70 11 94357 245 32418913
Arthropathy 19.36 10.70 22 94346 22467 32396691
Movement disorder 19.34 10.70 73 94295 10918 32408240
Skin ulcer 19.33 10.70 19 94349 20740 32398418
Clumsiness 19.32 10.70 23 94345 1503 32417655
Disinhibition 19.30 10.70 31 94337 2689 32416469
Claustrophobia 19.27 10.70 11 94357 248 32418910
Hyperbilirubinaemia 19.24 10.70 14 94354 17716 32401442
Hallucinations, mixed 19.24 10.70 31 94337 2696 32416462
Transplant rejection 19.22 10.70 3 94365 9996 32409162
Somnambulism 19.17 10.70 34 94334 3198 32415960
Subacute endocarditis 19.15 10.70 7 94361 52 32419106
Peritonitis 19.05 10.70 22 94346 22308 32396850
Full blood count decreased 19.03 10.70 13 94355 16997 32402161
Arthritis 19.02 10.70 30 94338 26662 32392496
Personality change 18.98 10.70 44 94324 5015 32414143
Pulmonary contusion 18.81 10.70 7 94361 55 32419103
Metastases to liver 18.78 10.70 7 94361 12925 32406233
Schizoaffective disorder 18.72 10.70 21 94347 1287 32417871
Illusion 18.66 10.70 17 94351 811 32418347
Rectal haemorrhage 18.33 10.70 52 94316 37371 32381787
Angina pectoris 18.25 10.70 40 94328 31386 32387772
Sensory integrative dysfunction 18.25 10.70 6 94362 31 32419127
Reaction to excipient 18.18 10.70 13 94355 437 32418721
Blood creatine phosphokinase increased 18.17 10.70 207 94161 45269 32373889
Penile haemorrhage 18.13 10.70 15 94353 628 32418530
Emotional disorder of childhood 18.09 10.70 6 94362 32 32419126
Congestive hepatopathy 17.90 10.70 25 94343 1915 32417243
Lymphadenopathy 17.86 10.70 32 94336 27050 32392108
Cellulitis 17.80 10.70 80 94288 50150 32369008
Hostility 17.66 10.70 17 94351 870 32418288
Basal cell carcinoma 17.64 10.70 15 94353 17553 32401605
Drug level increased 17.54 10.70 109 94259 19971 32399187
Wheezing 17.51 10.70 52 94316 36822 32382336
Femoral nerve palsy 17.50 10.70 6 94362 36 32419122
Apnoea 17.42 10.70 51 94317 6692 32412466
Cataract 17.40 10.70 27 94341 24156 32395002
Blunted affect 17.37 10.70 11 94357 301 32418857
Tearfulness 17.28 10.70 23 94345 1683 32417475
Cytopenia 17.26 10.70 4 94364 10060 32409098
Leukopenia 17.23 10.70 103 94265 60019 32359139
Diabetes mellitus 17.20 10.70 70 94298 45103 32374055
Priapism 17.20 10.70 42 94326 4949 32414209
Obsessive thoughts 17.19 10.70 15 94353 676 32418482
Neoplasm progression 17.17 10.70 19 94349 19639 32399519
Rebound psychosis 17.05 10.70 9 94359 173 32418985
Antipsychotic drug level decreased 17.02 10.70 17 94351 911 32418247
Stupor 17.01 10.70 31 94337 2978 32416180
Abdominal pain upper 16.94 10.70 120 94248 67218 32351940
Dyskinesia 16.93 10.70 122 94246 23481 32395677
Multiple organ dysfunction syndrome 16.84 10.70 126 94242 69728 32349430
Deep vein thrombosis 16.79 10.70 112 94256 63601 32355557
White blood cell count increased 16.78 10.70 189 94179 41213 32377945
Hepatic function abnormal 16.75 10.70 70 94298 44770 32374388
Mobility decreased 16.63 10.70 36 94332 28373 32390785
Paradoxical drug reaction 16.58 10.70 30 94338 2866 32416292
Blood alcohol increased 16.41 10.70 15 94353 719 32418439
Inappropriate antidiuretic hormone secretion 16.40 10.70 74 94294 11989 32407169
Hangover 16.34 10.70 18 94350 1081 32418077
Learning disorder 16.29 10.70 16 94352 840 32418318
Liver disorder 16.24 10.70 43 94325 31611 32387547
Abdominal discomfort 16.24 10.70 88 94280 52536 32366622
Hyperglycaemia 16.24 10.70 57 94311 38334 32380824
Ex-drug abuser 16.14 10.70 8 94360 134 32419024
Neuromuscular toxicity 16.14 10.70 6 94362 47 32419111
Incoherent 16.02 10.70 38 94330 4396 32414762
Hepatocellular injury 15.98 10.70 127 94241 25191 32393967
Bradycardia neonatal 15.94 10.70 17 94351 984 32418174
Tuberculosis 15.94 10.70 3 94365 8726 32410432
COVID-19 pneumonia 15.91 10.70 3 94365 8717 32410441
Septic shock 15.90 10.70 126 94242 68863 32350295
Pathogen resistance 15.88 10.70 4 94364 9506 32409652
Drug tolerance 15.85 10.70 26 94342 2295 32416863
Drug withdrawal maintenance therapy 15.85 10.70 7 94361 89 32419069
Affective disorder 15.83 10.70 33 94335 3500 32415658
Apathy 15.67 10.70 49 94319 6666 32412492
Myofascial pain syndrome 15.67 10.70 11 94357 359 32418799
Chemical poisoning 15.64 10.70 7 94361 92 32419066
Myocardial depression 15.61 10.70 6 94362 52 32419106
Slow speech 15.61 10.70 17 94351 1008 32418150
Graft versus host disease 15.44 10.70 6 94362 10800 32408358
Haemorrhage intracranial 15.43 10.70 14 94354 15873 32403285
Substance use disorder 15.38 10.70 9 94359 213 32418945
Rhinorrhoea 15.30 10.70 27 94341 22959 32396199
Bezoar 15.29 10.70 16 94352 906 32418252
Diffuse large B-cell lymphoma 15.26 10.70 3 94365 8459 32410699
Incorrect route of product administration 15.25 10.70 71 94297 11655 32407503
Inflammation 15.22 10.70 30 94338 24463 32394695
Abdominal distension 15.16 10.70 87 94281 51208 32367950
Alcohol intolerance 15.12 10.70 11 94357 380 32418778
Haemophagocytic lymphohistiocytosis 15.07 10.70 7 94361 11328 32407830
Contraindicated product administered 15.01 10.70 20 94348 19056 32400102
Drug tolerance increased 14.99 10.70 12 94356 479 32418679
Myocarditis 14.94 10.70 70 94298 11520 32407638
Nephrolithiasis 14.93 10.70 36 94332 27318 32391840
Prostatic specific antigen increased 14.86 10.70 10 94358 13177 32405981
Porphyria acute 14.81 10.70 7 94361 105 32419053
Staring 14.58 10.70 20 94348 1506 32417652
Breech presentation 14.56 10.70 8 94360 167 32418991
Aspartate aminotransferase increased 14.54 10.70 123 94245 66306 32352852
Crime 14.52 10.70 6 94362 64 32419094
Hepatotoxicity 14.49 10.70 21 94347 19316 32399842
Anticonvulsant drug level increased 14.46 10.70 20 94348 1518 32417640
Alcoholism 14.44 10.70 32 94336 3540 32415618
Vascular stenosis 14.39 10.70 8 94360 171 32418987
Poverty of speech 14.39 10.70 9 94359 241 32418917
Bone pain 14.37 10.70 23 94345 20321 32398837
Muscle twitching 14.36 10.70 57 94311 8727 32410431
Physical assault 14.35 10.70 17 94351 1105 32418053
Depressive symptom 14.33 10.70 22 94346 1836 32417322
Colon cancer 14.29 10.70 4 94364 8862 32410296
Aura 14.28 10.70 10 94358 325 32418833
Therapeutic response decreased 14.24 10.70 34 94334 25886 32393272
Post-traumatic stress disorder 14.21 10.70 22 94346 1849 32417309
Blood bilirubin increased 14.21 10.70 61 94307 38723 32380435
Neurodevelopmental disorder 14.19 10.70 8 94360 176 32418982
Blood ketone body increased 14.17 10.70 11 94357 420 32418738
Upper gastrointestinal haemorrhage 14.15 10.70 30 94338 23819 32395339
Hypoglycaemia 14.13 10.70 96 94272 54286 32364872
Cardiac disorder 14.05 10.70 68 94300 41798 32377360
Hanging 14.03 10.70 7 94361 119 32419039
Haemorrhage 14.01 10.70 85 94283 49363 32369795
Selective mutism 13.97 10.70 6 94362 71 32419087
Hypertension 13.96 10.70 284 94084 131466 32287692
Mood altered 13.94 10.70 57 94311 8847 32410311
Diverticulitis 13.93 10.70 21 94347 19007 32400151
Analgesic drug level above therapeutic 13.91 10.70 9 94359 256 32418902
Lymphoma 13.86 10.70 7 94361 10793 32408365
Suspected suicide attempt 13.82 10.70 7 94361 123 32419035
Delirium tremens 13.75 10.70 12 94356 541 32418617
Forearm fracture 13.74 10.70 6 94362 74 32419084
Chronic obstructive pulmonary disease 13.71 10.70 84 94284 48669 32370489
Haemorrhagic fever 13.69 10.70 5 94363 37 32419121
Oedema 13.65 10.70 76 94292 45071 32374087
Metastases to bone 13.65 10.70 7 94361 10703 32408455
Herbal interaction 13.61 10.70 10 94358 351 32418807
Syncope 13.60 10.70 182 94186 89942 32329216
Sluggishness 13.57 10.70 30 94338 3313 32415845
Social anxiety disorder 13.54 10.70 9 94359 268 32418890
Congenital pulmonary valve atresia 13.53 10.70 6 94362 77 32419081
Sciatic nerve neuropathy 13.53 10.70 6 94362 77 32419081
Muscular weakness 13.46 10.70 129 94239 67800 32351358
Wrong dose 13.45 10.70 11 94357 453 32418705
Pneumoconiosis 13.37 10.70 9 94359 274 32418884
Dissociation 13.32 10.70 17 94351 1193 32417965
Flushing 13.31 10.70 46 94322 31081 32388077
Prescription form tampering 13.27 10.70 12 94356 567 32418591
Skin lesion 13.27 10.70 24 94344 20217 32398941
Terminal insomnia 13.24 10.70 11 94357 463 32418695
Febrile bone marrow aplasia 13.19 10.70 4 94364 8411 32410747
Squamous cell carcinoma of skin 13.17 10.70 6 94362 9820 32409338
Oxygen saturation abnormal 13.15 10.70 17 94351 1209 32417949
Hallucination 13.05 10.70 220 94148 52399 32366759
Electrocardiogram J wave 12.99 10.70 4 94364 16 32419142
Panic disorder 12.99 10.70 18 94350 1369 32417789
Patient uncooperative 12.96 10.70 10 94358 378 32418780
Accident at work 12.88 10.70 13 94355 705 32418453
Dry skin 12.76 10.70 34 94334 24944 32394214
Eosinophilic myocarditis 12.75 10.70 11 94357 488 32418670
Neoplasm malignant 12.74 10.70 22 94346 18863 32400295
Haematocrit decreased 12.73 10.70 48 94320 31614 32387544
Hepatitis cholestatic 12.73 10.70 4 94364 8221 32410937
Apparent life threatening event 12.63 10.70 8 94360 219 32418939
Irregular breathing 12.62 10.70 7 94361 149 32419009
Adverse drug reaction 12.62 10.70 36 94332 25825 32393333
Physical abuse 12.61 10.70 4 94364 18 32419140
Communication disorder 12.60 10.70 25 94343 2559 32416599
Posterior reversible encephalopathy syndrome 12.60 10.70 6 94362 9570 32409588
Respiratory failure 12.59 10.70 227 94141 106955 32312203
Respiratory rate decreased 12.58 10.70 21 94347 1881 32417277
Neutropenic sepsis 12.56 10.70 11 94357 12688 32406470
Immune reconstitution inflammatory syndrome 12.56 10.70 6 94362 9553 32409605
Mucosal erosion 12.44 10.70 14 94354 861 32418297
Polyneuropathy 12.42 10.70 12 94356 13203 32405955
Xanthelasma 12.41 10.70 6 94362 95 32419063
Nephrotic syndrome 12.40 10.70 3 94365 7326 32411832
Thrombotic microangiopathy 12.38 10.70 6 94362 9476 32409682
Stress at work 12.37 10.70 7 94361 155 32419003
Therapeutic product effect incomplete 12.28 10.70 70 94298 41271 32377887
Antipsychotic drug level above therapeutic 12.24 10.70 16 94352 1150 32418008
Sciatic nerve injury 12.24 10.70 6 94362 98 32419060
Social avoidant behaviour 12.19 10.70 28 94340 3171 32415987
Hypersensitivity 12.17 10.70 108 94260 57650 32361508
Potentiating drug interaction 12.11 10.70 37 94331 4971 32414187
Protrusion tongue 12.02 10.70 8 94360 239 32418919
Psoriatic arthropathy 11.87 10.70 21 94347 17839 32401319
Neutrophil count decreased 11.85 10.70 84 94284 47055 32372103
Disturbance in social behaviour 11.85 10.70 19 94349 1646 32417512
Cerebellar syndrome 11.85 10.70 22 94346 2144 32417014
Hyperthermia 11.84 10.70 62 94306 10666 32408492
Blood count abnormal 11.84 10.70 12 94356 12914 32406244
Impaired driving ability 11.84 10.70 24 94344 2495 32416663
Family stress 11.83 10.70 7 94361 169 32418989
Atrial septal defect 11.82 10.70 46 94322 6979 32412179
Delusional disorder, unspecified type 11.73 10.70 13 94355 786 32418372
Osteomyelitis 11.69 10.70 17 94351 15616 32403542
Bradycardia 11.66 10.70 281 94087 71281 32347877
Speech disorder 11.63 10.70 122 94246 26131 32393027
Cerebrovascular stenosis 11.62 10.70 6 94362 110 32419048
Kidney transplant rejection 11.60 10.70 4 94364 7751 32411407
Tetanus 11.50 10.70 5 94363 61 32419097
Squamous cell carcinoma 11.47 10.70 9 94359 10959 32408199
Erythrosis 11.43 10.70 5 94363 62 32419096
Autism spectrum disorder 11.42 10.70 20 94348 1862 32417296
Sexually inappropriate behaviour 11.40 10.70 10 94358 454 32418704
Hepatic enzyme increased 11.39 10.70 62 94306 36975 32382183
Blood urine 11.36 10.70 10 94358 456 32418702
Hepatic steatosis 11.34 10.70 83 94285 16050 32403108
Laboratory test abnormal 11.33 10.70 24 94344 19063 32400095
Faeces discoloured 11.30 10.70 16 94352 14861 32404297
Alanine aminotransferase increased 11.29 10.70 160 94208 78319 32340839
Skull fractured base 11.27 10.70 7 94361 185 32418973
Stab wound 11.27 10.70 7 94361 185 32418973
Binge drinking 11.26 10.70 3 94365 6 32419152
Blood glucose increased 11.25 10.70 128 94240 65113 32354045
Carbon monoxide poisoning 11.24 10.70 6 94362 118 32419040
Swelling 11.20 10.70 65 94303 38157 32381001
Erectile dysfunction 11.18 10.70 97 94271 19742 32399416
Refusal of treatment by patient 11.14 10.70 37 94331 5194 32413964
Headache 11.12 10.70 461 93907 195736 32223422
Drug level below therapeutic 11.10 10.70 32 94336 4163 32414995
Nephropathy toxic 11.05 10.70 11 94357 11935 32407223
CSF white blood cell count positive 11.02 10.70 4 94364 29 32419129
Cerebral infarction 11.02 10.70 42 94326 27572 32391586
Fungal infection 11.01 10.70 17 94351 15238 32403920
Coma scale 10.94 10.70 3 94365 7 32419151
Haemoptysis 10.94 10.70 55 94313 33470 32385688
Product counterfeit 10.91 10.70 7 94361 196 32418962
Blood alkaline phosphatase increased 10.89 10.70 52 94316 32080 32387078
Haemolytic anaemia 10.88 10.70 9 94359 10675 32408483
Frequent bowel movements 10.88 10.70 7 94361 9445 32409713
Gait disturbance 10.86 10.70 308 94060 80100 32339058
Blood glucose decreased 10.84 10.70 14 94354 13520 32405638
Myositis 10.79 10.70 10 94358 11225 32407933
Drug hypersensitivity 10.79 10.70 149 94219 73251 32345907
Back pain 10.71 10.70 243 94125 110810 32308348

Pharmacologic Action:

SourceCodeDescription
ATC N05BA01 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
FDA CS M0002356 Benzodiazepines
MeSH PA D000759 Adjuvants, Anesthesia
MeSH PA D000777 Anesthetics
MeSH PA D018686 Anesthetics, Intravenous
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D000927 Anticonvulsants
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D009125 Muscle Relaxants, Central
MeSH PA D009465 Neuromuscular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
FDA EPC N0000175694 Benzodiazepine
CHEBI has role CHEBI:35474 minor tranquilisers
CHEBI has role CHEBI:35623 antiepileptic
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:35717 sedatives
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Alcohol withdrawal delirium indication 8635005
Anxiety indication 48694002
Sedation indication 72641008
Tetanus indication 76902006 DOID:11338
Epilepsy indication 84757009 DOID:1826
Alcohol withdrawal syndrome indication 191480000
Spasticity indication 221360009
Status epilepticus indication 230456007 DOID:1824
Induce Anterograde Amnesia indication
Preoperative Anxiety indication
Panic disorder off-label use 371631005 DOID:594
Cocaine-Associated Acute Ischemic Heart Disease off-label use
Disorder of lung contraindication 19829001 DOID:850
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Decreased respiratory function contraindication 80954004
Open-angle glaucoma contraindication 84494001 DOID:1067
Myasthenia gravis contraindication 91637004 DOID:437
Hypoalbuminemia contraindication 119247004
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Severe chronic obstructive pulmonary disease contraindication 313299006
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.06 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 8927497 July 21, 2025 NASAL ADMINISTRATION OF DIAZEPAM FOR TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY IN PATIENTS 6 YEARS OF AGE AND OLDER
5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 8927497 July 21, 2025 NASAL ADMINISTRATION OF DIAZEPAM FOR TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY IN PATIENTS 6 YEARS OF AGE AND OLDER
7.5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 8927497 July 21, 2025 NASAL ADMINISTRATION OF DIAZEPAM FOR TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY IN PATIENTS 6 YEARS OF AGE AND OLDER

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
10MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2023 NEW PRODUCT
5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2023 NEW PRODUCT
7.5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2023 NEW PRODUCT
10MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2027 INDICATED FOR THE ACUTE TX OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY (I.E. SEIZURE CLUSTERS, ACUTE REPETITIVE SEIZURES) THAT ARE DISTINCT FROM A PATIENT’S USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 6 YEARS OF AGE AND OLDER
5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2027 INDICATED FOR THE ACUTE TX OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY (I.E. SEIZURE CLUSTERS, ACUTE REPETITIVE SEIZURES) THAT ARE DISTINCT FROM A PATIENT’S USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 6 YEARS OF AGE AND OLDER
7.5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2027 INDICATED FOR THE ACUTE TX OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY (I.E. SEIZURE CLUSTERS, ACUTE REPETITIVE SEIZURES) THAT ARE DISTINCT FROM A PATIENT’S USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 6 YEARS OF AGE AND OLDER

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA A receptor alpha-5/beta-2/gamma-3 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.20 WOMBAT-PK CHEMBL
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 7.14 WOMBAT-PK CHEMBL
GABA-A receptor alpha-2/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.70 WOMBAT-PK CHEMBL
GABA-A receptor alpha-3/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.65 WOMBAT-PK CHEMBL
GABA-A receptor alpha-5/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.96 WOMBAT-PK CHEMBL
GABA-A receptor alpha-1/beta-2/gamma-3 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 6.71 WOMBAT-PK CHEMBL
GABA-A receptor alpha-1/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.85 WOMBAT-PK CHEMBL
GABA A receptor alpha-3/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.94 WOMBAT-PK CHEMBL
GABA A receptor alpha-3/beta-2/gamma-3 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 6.67 WOMBAT-PK CHEMBL
GABA A receptor alpha-5/beta-3/gamma-3 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.20 WOMBAT-PK CHEMBL
GABA A receptor alpha-5/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 8.00 WOMBAT-PK CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-5 Ion channel Kd 7.64 CHEMBL
Cytochrome P450 3A4 Enzyme Ki 4.42 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR ALLOSTERIC MODULATOR Ki 4.10 IUPHAR
Adenosine receptor A3 GPCR IC50 7.92 CHEMBL
Aldo-keto reductase family 1 member C1 Enzyme IC50 5.25 CHEMBL
Aldo-keto reductase family 1 member C2 Enzyme IC50 5.62 CHEMBL
Aldo-keto reductase family 1 member C3 Enzyme IC50 4.08 CHEMBL
Cholinesterase Enzyme Ki 7.37 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-1 Ion channel Ki 7.96 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-2 Ion channel Ki 7.82 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-5 Ion channel Ki 8.01 CHEMBL
GABA A receptor alpha-6/beta-2/gamma-2 Ion channel Ki 8.68 CHEMBL
GABA-A receptor; alpha-1/beta-2/gamma-2 Ion channel Ki 7.92 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 4.07 CHEMBL
GABA A receptor alpha-2/beta-2/gamma-2 Ion channel Ki 7.70 CHEMBL
GABA A receptor alpha-5/beta-3/gamma-2 Ion channel Ki 7.96 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 8.54 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 8 CHEMBL
GABA A receptor alpha-3/beta-2/gamma-2 Ion channel Ki 7.86 CHEMBL
Fatty acid-binding protein, liver Unclassified Ki 6.27 CHEMBL
Acetylcholinesterase Enzyme Ki 4.89 CHEMBL
Translocator protein Membrane receptor Kd 6.67 CHEMBL
Thyrotropin-releasing hormone receptor GPCR ANTAGONIST Ki 5.15 IUPHAR

External reference:

IDSource
4017796 VUID
N0000146157 NUI
D00293 KEGG_DRUG
4017796 VANDF
C0012010 UMLSCUI
CHEBI:49575 CHEBI
DZP PDB_CHEM_ID
CHEMBL12 ChEMBL_ID
DB00829 DRUGBANK_ID
D003975 MESH_DESCRIPTOR_UI
3016 PUBCHEM_CID
3364 IUPHAR_LIGAND_ID
1295 INN_ID
Q3JTX2Q7TU UNII
202472 RXNORM
3018 MMSL
4573 MMSL
894 MMSL
d00148 MMSL
001461 NDDF
387264003 SNOMEDCT_US
48546005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Diazepam Intensol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3185 SOLUTION, CONCENTRATE 5 mg ORAL ANDA 24 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0054-3188 SOLUTION 5 mg ORAL ANDA 26 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0121-0905 SOLUTION 5 mg ORAL ANDA 24 sections
Valium HUMAN PRESCRIPTION DRUG LABEL 1 0140-0004 TABLET 2 mg ORAL NDA 28 sections
Valium HUMAN PRESCRIPTION DRUG LABEL 1 0140-0005 TABLET 5 mg ORAL NDA 28 sections
Valium HUMAN PRESCRIPTION DRUG LABEL 1 0140-0006 TABLET 10 mg ORAL NDA 28 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0172-3925 TABLET 2 mg ORAL ANDA 16 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0172-3926 TABLET 5 mg ORAL ANDA 16 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0172-3927 TABLET 10 mg ORAL ANDA 16 sections
Diastat HUMAN PRESCRIPTION DRUG LABEL 1 0187-0658 GEL 10 mg RECTAL NDA 19 sections
Diastat HUMAN PRESCRIPTION DRUG LABEL 1 0187-0659 GEL 20 mg RECTAL NDA 19 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-0271 TABLET 2 mg ORAL ANDA 28 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-0345 TABLET 5 mg ORAL ANDA 28 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-0477 TABLET 10 mg ORAL ANDA 28 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0404-9848 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 15 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-1273 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 21 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-1273 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 21 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-3213 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 20 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-3213 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 20 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0527-1767 SOLUTION 5 mg ORAL ANDA 21 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0527-1768 SOLUTION, CONCENTRATE 5 mg ORAL ANDA 21 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-7799 TABLET 5 mg ORAL ANDA 16 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-7800 TABLET 10 mg ORAL ANDA 14 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0641-6244 INJECTION 5 mg INTRAMUSCULAR ANDA 16 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0904-5880 TABLET 5 mg ORAL ANDA 26 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0904-7117 SOLUTION 5 mg ORAL ANDA 26 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 10544-161 TABLET 10 mg ORAL ANDA 26 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 11704-600 INJECTION 10 mg INTRAMUSCULAR NDA 22 sections
DIAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 12634-529 TABLET 5 mg ORAL ANDA 14 sections
DIAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 12634-698 TABLET 10 mg ORAL ANDA 14 sections