dextrothyroxine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
846 51-49-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sodium dextrothyroxine
  • D-Thyroxine
  • choloxin
  • dextrothyroxine
  • dextrothyroxine sodium
The dextrorotary isomer of the synthetic THYROXINE.
  • Molecular weight: 776.87
  • Formula: C15H11I4NO4
  • CLOGP: 3.51
  • LIPINSKI: 1
  • HAC: 5
  • HDO: 3
  • TPSA: 92.78
  • ALOGS: -4.94
  • ROTB: 5

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
4 mg O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
April 14, 1967 FDA ABBVIE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C10AX01 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
Other lipid modifying agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hyperlipidemia indication 55822004 DOID:1168

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.08 acidic
pKa2 6.63 acidic
pKa3 8.6 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Thyroid hormone receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL
Glutamate NMDA receptor Ion channel IC50 6.48 CHEMBL
Thyroid hormone receptor beta Transcription factor IC50 7.46 CHEMBL

External reference:

IDSource
D003918 MESH_DESCRIPTOR_UI
4022400 VUID
N0000020406 NUI
C0011824 UMLSCUI
D03750 KEGG_DRUG
0H00N2AHSP UNII
7054-08-2 SECONDARY_CAS_RN
847003 SNOMEDCT_US
4022400 VANDF
004779 NDDF
3292 RXNORM
59170000 SNOMEDCT_US
CHEMBL559 ChEMBL_ID
DB00509 DRUGBANK_ID
CHEMBL1200777 ChEMBL_ID
CHEBI:30659 CHEBI
6951 IUPHAR_LIGAND_ID
CHEMBL3545058 ChEMBL_ID
8730 PUBCHEM_CID

Pharmaceutical products:

None