glucose 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
845 492-61-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dextrose
  • D-Glucose
  • (+)-Glucose
  • glucose
  • dextrose monohydrate
  • anhydrous dextrose
  • glucose monohydrate
  • anhydrous glucose
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
  • Molecular weight: 180.16
  • Formula: C6H12O6
  • CLOGP: -2.21
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 5
  • TPSA: 110.38
  • ALOGS: 0.64
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility) 909 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Jan. 17, 1946 FDA B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myelosuppression 561.37 9.94 435 131847 23268 63333472
Drug ineffective 364.68 9.94 1052 131230 1043713 62313027
Hand deformity 310.97 9.94 4 132278 159453 63197287
Systemic lupus erythematosus 298.02 9.94 41 132241 208877 63147863
Hypokalaemia 286.68 9.94 654 131628 103150 63253590
Glossodynia 270.09 9.94 29 132253 178847 63177893
Contraindicated product administered 244.06 9.94 75 132207 217573 63139167
Alopecia 233.19 9.94 216 132066 337320 63019420
Joint swelling 218.96 9.94 216 132066 327450 63029290
Arthropathy 218.60 9.94 108 132174 234684 63122056
Cardiac failure congestive 218.12 9.94 548 131734 91885 63264855
Hyperkalaemia 214.06 9.94 396 131886 53807 63302933
Wound 206.51 9.94 44 132238 163219 63193521
Pericarditis 202.04 9.94 20 132262 131559 63225181
Rheumatoid arthritis 195.48 9.94 146 132136 253673 63103067
Drug intolerance 183.53 9.94 224 132058 308437 63048303
Therapeutic product effect decreased 182.62 9.94 87 132195 193100 63163640
Colitis microscopic 175.88 9.94 150 132132 9189 63347551
Abdominal discomfort 171.35 9.94 252 132030 320633 63036107
Duodenal ulcer perforation 166.51 9.94 3 132279 87206 63269534
Normal labour 162.40 9.94 55 132227 462 63356278
Helicobacter infection 156.85 9.94 9 132273 92776 63263964
Atrial fibrillation 156.79 9.94 567 131715 116069 63240671
Hypervolaemia 155.26 9.94 240 132042 28173 63328567
Pneumonia 152.75 9.94 1537 130745 455230 62901510
Musculoskeletal stiffness 150.25 9.94 100 132182 184518 63172222
Blood potassium decreased 149.82 9.94 294 131988 41732 63315008
Arthralgia 146.06 9.94 651 131631 569059 62787681
Discomfort 145.42 9.94 84 132198 167290 63189450
Acute kidney injury 138.87 9.94 982 131300 262433 63094307
Lower respiratory tract infection 137.12 9.94 52 132230 132255 63224485
Swelling 134.88 9.94 229 132053 275149 63081591
Pain 133.13 9.94 951 131331 739677 62617063
Dehydration 128.14 9.94 705 131577 172649 63184091
Pneumonia aspiration 126.00 9.94 244 132038 34296 63322444
Bone marrow failure 124.52 9.94 221 132061 29069 63327671
Product use issue 121.76 9.94 169 132113 220351 63136389
Hypoxia 121.13 9.94 335 131947 59457 63297283
Sepsis 120.12 9.94 633 131649 152490 63204250
Oedema peripheral 117.61 9.94 736 131546 188775 63167965
Pulmonary hypertension 117.24 9.94 247 132035 36876 63319864
Folliculitis 115.32 9.94 8 132274 70309 63286431
Anaemia 114.61 9.94 1021 131261 292409 63064331
White blood cell count decreased 113.21 9.94 581 131701 138523 63218217
Muscle injury 111.48 9.94 6 132276 65339 63291401
Respiratory failure 108.30 9.94 460 131822 101398 63255342
Hypersensitivity 104.66 9.94 290 131992 292395 63064345
Acute respiratory failure 103.78 9.94 225 132057 34260 63322480
Glaucoma 103.71 9.94 160 132122 18745 63337995
Delivery 103.51 9.94 53 132229 1350 63355390
Cytokine release syndrome 103.28 9.94 138 132144 14176 63342564
Hypotension 102.58 9.94 941 131341 271663 63085077
Hepatic enzyme increased 95.60 9.94 172 132110 202156 63154584
Infusion related reaction 94.83 9.94 234 132048 245287 63111453
Rash 91.18 9.94 740 131542 560131 62796609
Synovitis 90.94 9.94 156 132126 186762 63169978
Treatment failure 89.81 9.94 174 132108 198869 63157871
Drug hypersensitivity 89.41 9.94 339 131943 310348 63046392
Plasma cell myeloma 87.92 9.94 216 132066 35689 63321051
Irritable bowel syndrome 87.72 9.94 31 132251 82381 63274359
Right ventricular failure 86.72 9.94 140 132142 17048 63339692
Impaired healing 82.76 9.94 56 132226 102486 63254254
Gastrointestinal haemorrhage 82.74 9.94 362 131920 80814 63275926
Diverticulitis 79.48 9.94 221 132061 39336 63317404
Neutrophil count decreased 78.97 9.94 278 132004 56128 63300612
Pleural effusion 76.97 9.94 391 131891 92819 63263921
Ill-defined disorder 75.40 9.94 38 132244 81717 63275023
Intentional product use issue 74.64 9.94 94 132188 127798 63228942
Off label use 73.47 9.94 978 131304 673484 62683256
Psoriatic arthropathy 72.50 9.94 51 132231 91469 63265271
Pulmonary arterial hypertension 72.19 9.94 151 132131 22426 63334314
Febrile neutropenia 70.92 9.94 456 131826 117993 63238747
Bronchitis 68.78 9.94 471 131811 124464 63232276
Drug abuse 67.94 9.94 33 132249 72485 63284255
Hyponatraemia 67.73 9.94 432 131850 111468 63245272
Renal failure 66.83 9.94 447 131835 117205 63239535
Cardiac arrest 65.40 9.94 372 131910 92173 63264567
Fluid retention 61.45 9.94 267 132015 59419 63297321
Diarrhoea 60.49 9.94 1932 130350 713434 62643306
Hypoglycaemia 59.79 9.94 266 132016 59799 63296941
Coma 59.58 9.94 279 132003 64085 63292655
Pulmonary oedema 59.21 9.94 249 132033 54624 63302116
Dyspnoea 58.25 9.94 1795 130487 659518 62697222
Blood cholesterol increased 58.17 9.94 66 132216 93966 63262774
Gastrooesophageal reflux disease 57.12 9.94 368 131914 95271 63261469
Nasopharyngitis 57.11 9.94 304 131978 253953 63102787
Platelet count decreased 55.94 9.94 424 131858 115698 63241042
Blood urea increased 54.59 9.94 149 132133 26230 63330510
Asthenia 54.19 9.94 1110 131172 382494 62974246
Blood bilirubin increased 52.80 9.94 184 132098 36956 63319784
Macular degeneration 52.78 9.94 140 132142 24236 63332504
Mental status changes 52.72 9.94 192 132090 39407 63317333
International normalised ratio increased 52.71 9.94 214 132068 46211 63310529
Electrolyte imbalance 51.52 9.94 123 132159 19953 63336787
Death 51.13 9.94 1078 131204 373303 62983437
Renal ischaemia 49.87 9.94 25 132257 608 63356132
Blister 49.85 9.94 124 132158 129690 63227050
Chronic obstructive pulmonary disease 49.68 9.94 260 132022 62426 63294314
Thrombocytopenia 49.48 9.94 507 131775 150650 63206090
Haemoglobin decreased 48.11 9.94 489 131793 144996 63211744
Non-cardiogenic pulmonary oedema 46.48 9.94 25 132257 706 63356034
Diabetes insipidus 45.06 9.94 40 132242 2585 63354155
Encephalopathy 44.62 9.94 179 132103 38441 63318299
Injection site pain 44.56 9.94 131 132151 129669 63227071
Hip arthroplasty 44.15 9.94 22 132260 47624 63309116
Blood alkaline phosphatase increased 44.06 9.94 192 132090 42775 63313965
Deep vein thrombosis 42.63 9.94 310 131972 83490 63273250
PO2 increased 42.18 9.94 25 132257 854 63355886
Premature delivery 41.31 9.94 148 132134 30133 63326607
Dementia 39.73 9.94 107 132175 18687 63338053
Heparin-induced thrombocytopenia 39.07 9.94 48 132234 4534 63352206
Cardiac failure 38.80 9.94 318 131964 88824 63267916
Injection site reaction 38.51 9.94 39 132243 58485 63298255
Blood magnesium decreased 38.44 9.94 85 132197 13113 63343627
Suicidal ideation 38.40 9.94 44 132238 62377 63294363
Granulocytopenia 38.36 9.94 53 132229 5619 63351121
Fibromyalgia 38.27 9.94 68 132214 80352 63276388
Colitis 38.25 9.94 201 132081 48327 63308413
Toxic epidermal necrolysis 38.19 9.94 128 132154 25206 63331534
Multiple allergies 38.08 9.94 87 132195 13715 63343025
Injection site bruising 37.86 9.94 20 132262 41890 63314850
Condition aggravated 37.77 9.94 600 131682 401617 62955123
Hypomagnesaemia 37.13 9.94 138 132144 28599 63328141
Knee arthroplasty 36.96 9.94 35 132247 54171 63302569
PCO2 increased 36.64 9.94 26 132256 1213 63355527
Pancytopenia 36.56 9.94 335 131947 96598 63260142
Abortion spontaneous 36.45 9.94 27 132255 47168 63309572
Toxicity to various agents 36.12 9.94 335 131947 246915 63109825
Skin reaction 35.99 9.94 89 132193 14760 63341980
Septic shock 35.93 9.94 250 132032 66379 63290361
Coagulopathy 35.70 9.94 109 132173 20435 63336305
Therapeutic product effect incomplete 35.55 9.94 137 132145 124919 63231821
Inflammation 35.29 9.94 74 132208 82199 63274541
Gastrointestinal disorder 35.27 9.94 147 132135 131092 63225648
Cardiomegaly 34.97 9.94 98 132184 17516 63339224
Sleep disorder 34.46 9.94 74 132208 81492 63275248
Constipation 34.41 9.94 659 131623 224284 63132456
Intentional self-injury 34.40 9.94 6 132276 25681 63331059
Hypernatraemia 34.40 9.94 59 132223 7550 63349190
Atrial flutter 34.37 9.94 68 132214 9704 63347036
Paraesthesia oral 34.25 9.94 103 132179 19153 63337587
Brain natriuretic peptide increased 34.19 9.94 48 132234 5165 63351575
Peritonitis bacterial 33.61 9.94 46 132236 4833 63351907
Psoriasis 33.42 9.94 83 132199 86874 63269866
Infection 33.25 9.94 311 131971 228862 63127878
Decreased appetite 32.64 9.94 718 131564 250334 63106406
Grip strength decreased 32.64 9.94 4 132278 22283 63334457
Maternal exposure during pregnancy 31.77 9.94 299 131983 219763 63136977
Oxygen saturation abnormal 31.77 9.94 38 132244 3491 63353249
Mobility decreased 31.15 9.94 138 132144 121021 63235719
Therapeutic response decreased 31.14 9.94 50 132232 61475 63295265
Fatigue 30.83 9.94 1525 130757 886503 62470237
Cor pulmonale 30.77 9.94 29 132253 2025 63354715
Transfusion 30.54 9.94 85 132197 15132 63341608
Urinary tract infection 30.40 9.94 744 131538 263940 63092800
Arrhythmia 30.08 9.94 158 132124 37982 63318758
Liver injury 29.87 9.94 50 132232 60470 63296270
Cardiogenic shock 29.19 9.94 93 132189 17839 63338901
C-reactive protein abnormal 28.89 9.94 32 132250 46064 63310676
Injection site swelling 28.76 9.94 34 132248 47538 63309202
Pregnancy 28.55 9.94 21 132261 36815 63319925
Blood pressure decreased 28.31 9.94 232 132050 64790 63291950
Headache 28.28 9.94 1057 131225 632184 62724556
Bacteraemia 28.26 9.94 90 132192 17258 63339482
Bradycardia 28.07 9.94 254 132028 72973 63283767
Hypovolaemia 28.04 9.94 66 132216 10607 63346133
Blood potassium increased 28.04 9.94 93 132189 18216 63338524
Acute left ventricular failure 27.83 9.94 21 132261 1078 63355662
Injection site erythema 27.78 9.94 85 132197 83089 63273651
Calcium deficiency 27.58 9.94 21 132261 1093 63355647
Arthritis 27.46 9.94 136 132146 115785 63240955
Vaginal flatulence 27.28 9.94 34 132248 3259 63353481
Full blood count decreased 27.22 9.94 117 132165 25907 63330833
Blood bicarbonate decreased 27.02 9.94 32 132250 2909 63353831
Aspartate aminotransferase increased 26.81 9.94 297 131985 89980 63266760
Haematocrit decreased 26.38 9.94 156 132126 39184 63317556
Ascites 26.35 9.94 160 132122 40568 63316172
Exposure during pregnancy 26.18 9.94 203 132079 155344 63201396
Loss of personal independence in daily activities 26.12 9.94 109 132173 97181 63259559
Blood creatinine increased 26.08 9.94 289 131993 87555 63269185
Cardiac dysfunction 26.07 9.94 28 132254 2287 63354453
Prothrombin time prolonged 26.07 9.94 60 132222 9504 63347236
Leukocytosis 25.91 9.94 115 132167 25820 63330920
Blood glucose increased 25.53 9.94 277 132005 83479 63273261
Electrocardiogram abnormal 25.48 9.94 58 132224 9121 63347619
Joint stiffness 25.23 9.94 30 132252 41839 63314901
Failure to thrive 25.21 9.94 50 132232 7148 63349592
Wrong technique in product usage process 25.15 9.94 58 132224 62282 63294458
Chronic sinusitis 25.05 9.94 71 132211 12772 63343968
Blood immunoglobulin M increased 24.94 9.94 20 132262 1123 63355617
Atrioventricular block first degree 24.85 9.94 50 132232 7223 63349517
Generalised oedema 24.80 9.94 81 132201 15737 63341003
Vomiting 24.53 9.94 1412 130870 558205 62798535
Joint range of motion decreased 24.47 9.94 19 132263 32409 63324331
Stomatitis 24.31 9.94 179 132103 138546 63218194
Hyperglycaemia 24.31 9.94 160 132122 41707 63315033
Activated partial thromboplastin time prolonged 24.28 9.94 48 132234 6845 63349895
Adverse event 24.04 9.94 67 132215 67492 63289248
Type 2 diabetes mellitus 23.74 9.94 62 132220 63806 63292934
Osteoarthritis 23.66 9.94 110 132172 95233 63261507
Blood pH decreased 23.53 9.94 28 132254 2559 63354181
Pneumothorax spontaneous 23.51 9.94 17 132265 817 63355923
Peripheral circulatory failure 23.42 9.94 18 132264 950 63355790
Syncope 23.41 9.94 359 131923 117026 63239714
Tachypnoea 23.12 9.94 84 132198 17218 63339522
Disability 23.06 9.94 5 132277 18342 63338398
Respiratory distress 23.00 9.94 135 132147 33816 63322924
Hypophagia 22.96 9.94 127 132155 31132 63325608
Adverse drug reaction 22.86 9.94 87 132195 79627 63277113
Metabolic alkalosis 22.83 9.94 30 132252 3031 63353709
Small intestinal obstruction 22.81 9.94 87 132195 18250 63338490
Clostridium difficile colitis 22.70 9.94 94 132188 20475 63336265
Tonsillar haemorrhage 22.62 9.94 11 132271 250 63356490
Inappropriate schedule of product administration 22.37 9.94 126 132156 103839 63252901
Pulse absent 22.13 9.94 40 132242 5334 63351406
Atelectasis 22.02 9.94 96 132186 21387 63335353
Hypercapnia 21.83 9.94 40 132242 5391 63351349
Urine chloride decreased 21.79 9.94 8 132274 87 63356653
Blood albumin decreased 21.72 9.94 74 132208 14692 63342048
Urticaria 21.54 9.94 231 132051 165571 63191169
Oxygen consumption increased 21.48 9.94 33 132249 3851 63352889
Foot deformity 21.43 9.94 16 132266 27837 63328903
Metabolic acidosis 21.37 9.94 164 132118 44905 63311835
Immune effector cell-associated neurotoxicity syndrome 21.29 9.94 25 132257 2252 63354488
Electrocardiogram T wave peaked 21.16 9.94 10 132272 213 63356527
Oesophageal spasm 20.85 9.94 29 132253 3094 63353646
Product compounding quality issue 20.71 9.94 6 132276 28 63356712
Thyroid disorder 20.59 9.94 74 132208 15088 63341652
Completed suicide 20.55 9.94 199 132083 145474 63211266
Proctitis 20.53 9.94 39 132243 5402 63351338
Blood immunoglobulin A decreased 20.51 9.94 19 132263 1298 63355442
Tachycardia 20.45 9.94 353 131929 117803 63238937
Normal newborn 20.22 9.94 50 132232 8291 63348449
Nail dystrophy 20.14 9.94 17 132265 1026 63355714
Night sweats 20.02 9.94 45 132237 48769 63307971
Bezoar 19.96 9.94 20 132262 1506 63355234
Sinusitis 19.95 9.94 342 131940 226311 63130429
Cardiac failure acute 19.91 9.94 54 132228 9469 63347271
Hospice care 19.71 9.94 48 132234 7884 63348856
Dyspnoea exertional 19.58 9.94 202 132080 60100 63296640
Product residue present 19.51 9.94 32 132250 3947 63352793
Pulmonary embolism 19.26 9.94 346 131936 116338 63240402
Mental status changes postoperative 19.07 9.94 9 132273 191 63356549
Tenosynovitis 18.97 9.94 3 132279 13792 63342948
Supraventricular tachycardia 18.83 9.94 69 132213 14202 63342538
Metabolic encephalopathy 18.74 9.94 39 132243 5770 63350970
Chronic kidney disease 18.71 9.94 160 132122 45238 63311502
Malnutrition 18.55 9.94 72 132210 15226 63341514
Cellulitis 18.45 9.94 256 132026 81702 63275038
Oedema 18.11 9.94 295 131987 97327 63259413
Neuropathy peripheral 18.04 9.94 335 131947 113332 63243408
Prescribed overdose 18.00 9.94 27 132255 34126 63322614
Blood pressure fluctuation 17.96 9.94 44 132238 46273 63310467
Drug tolerance decreased 17.87 9.94 7 132275 17466 63339274
Weight increased 17.69 9.94 411 131871 260381 63096359
Catheter site haemorrhage 17.59 9.94 27 132255 3148 63353592
Acute respiratory distress syndrome 17.54 9.94 96 132186 23438 63333302
Injection site pruritus 17.38 9.94 43 132239 45073 63311667
Posthaemorrhagic hydrocephalus 17.31 9.94 5 132277 23 63356717
Urine sodium decreased 17.25 9.94 8 132274 163 63356577
Pseudomonal bacteraemia 17.13 9.94 19 132263 1609 63355131
Oesophageal pain 17.13 9.94 29 132253 3672 63353068
Coeliac disease 17.11 9.94 3 132279 12794 63343946
Abdominal pain 17.05 9.94 761 131521 292695 63064045
Fall 16.97 9.94 989 131293 391345 62965395
Skin candida 16.87 9.94 19 132263 1636 63355104
Neutropenia 16.63 9.94 480 131802 174525 63182215
Unresponsive to stimuli 16.56 9.94 124 132158 33692 63323048
Chest pain 16.51 9.94 577 131705 215382 63141358
Blood chloride decreased 16.49 9.94 36 132246 5506 63351234
Neuroglycopenia 16.42 9.94 11 132271 467 63356273
Hypoalbuminaemia 16.36 9.94 58 132224 11747 63344993
Torsade de pointes 16.32 9.94 63 132219 13288 63343452
Injury 16.18 9.94 88 132194 73159 63283581
Multiple drug therapy 16.12 9.94 28 132254 3618 63353122
Thrombosis 16.12 9.94 206 132076 64549 63292191
Pulmonary fibrosis 16.08 9.94 37 132245 39772 63316968
Posterior reversible encephalopathy syndrome 16.08 9.94 8 132274 17337 63339403
Catheter management 15.99 9.94 25 132257 2962 63353778
Ventricular tachycardia 15.91 9.94 83 132199 19896 63336844
Blood potassium abnormal 15.74 9.94 23 132259 2567 63354173
Lethargy 15.60 9.94 182 132100 55825 63300915
Acinetobacter sepsis 15.53 9.94 3 132279 0 63356740
Rheumatic disorder 15.46 9.94 25 132257 3047 63353693
Blood cholesterol decreased 15.44 9.94 14 132268 930 63355810
Emphysema 15.38 9.94 54 132228 10884 63345856
Bursitis 15.31 9.94 34 132248 37007 63319733
Cholelithiasis 15.15 9.94 149 132133 43776 63312964
Accidental exposure to product 15.10 9.94 21 132261 27384 63329356
Device difficult to use 15.08 9.94 4 132278 12792 63343948
Peptic ulcer 15.04 9.94 31 132251 4556 63352184
Nodule 15.02 9.94 13 132269 21013 63335727
Device related sepsis 15.02 9.94 29 132253 4065 63352675
Muscle spasticity 14.94 9.94 14 132268 21780 63334960
Congestive hepatopathy 14.89 9.94 24 132258 2918 63353822
Gastric polyps 14.86 9.94 26 132256 3379 63353361
Impaired work ability 14.83 9.94 9 132273 17466 63339274
Incision site pain 14.82 9.94 15 132267 1143 63355597
Drug eruption 14.82 9.94 23 132259 28671 63328069
Acne 14.78 9.94 16 132266 23277 63333463
Procedural pain 14.76 9.94 86 132196 21483 63335257
Melaena 14.68 9.94 111 132171 30254 63326486
Mitral valve incompetence 14.65 9.94 80 132202 19514 63337226
Hyperthyroidism 14.61 9.94 65 132217 14608 63342132
Pericardial effusion 14.60 9.94 110 132172 29948 63326792
Blood pressure diastolic abnormal 14.59 9.94 6 132276 14536 63342204
Burkholderia test positive 14.53 9.94 8 132274 237 63356503
Asthma 14.51 9.94 183 132099 127378 63229362
Confusion postoperative 14.50 9.94 8 132274 238 63356502
Multiple sclerosis relapse 14.49 9.94 52 132230 48426 63308314
Product selection error 14.49 9.94 6 132276 92 63356648
Cataract operation 14.35 9.94 34 132248 5488 63351252
Oxalosis 14.27 9.94 5 132277 47 63356693
Tendonitis 14.17 9.94 12 132270 19603 63337137
Catheter site extravasation 14 9.94 9 132273 356 63356384
Granulocyte count decreased 13.97 9.94 15 132267 1225 63355515
Facet joint syndrome 13.92 9.94 4 132278 12134 63344606
Alkalosis 13.87 9.94 9 132273 362 63356378
Hyperchloraemia 13.85 9.94 12 132270 751 63355989
Weight decreased 13.78 9.94 707 131575 276091 63080649
Hepatitis 13.76 9.94 40 132242 39748 63316992
Hypocalcaemia 13.72 9.94 113 132169 31600 63325140
Stevens-Johnson syndrome 13.67 9.94 94 132188 24856 63331884
Foetal death 13.58 9.94 52 132230 10928 63345812
Cardiac aneurysm 13.57 9.94 13 132269 927 63355813
Abdominal pain upper 13.53 9.94 327 131955 206117 63150623
Adenocarcinoma 13.50 9.94 23 132259 2927 63353813
Haemorrhage 13.48 9.94 190 132092 60832 63295908
Paraesthesia 13.43 9.94 238 132044 156728 63200012
Urosepsis 13.43 9.94 75 132207 18449 63338291
Parkinsonism 13.37 9.94 50 132232 10389 63346351
Thyroxine decreased 13.35 9.94 11 132271 642 63356098
Lymphoedema 13.35 9.94 54 132228 11638 63345102
Red blood cell sedimentation rate increased 13.26 9.94 47 132235 43935 63312805
Micturition disorder 13.25 9.94 21 132261 2517 63354223
Drug reaction with eosinophilia and systemic symptoms 13.23 9.94 32 132250 33804 63322936
General physical health deterioration 13.20 9.94 319 131963 201083 63155657
Female genital tract fistula 13.04 9.94 40 132242 7519 63349221
Skin dystrophy 13.03 9.94 5 132277 62 63356678
Migraine 13.01 9.94 145 132137 103201 63253539
Nodal arrhythmia 12.98 9.94 14 132268 1149 63355591
Lip erosion 12.96 9.94 13 132269 980 63355760
Ankylosing spondylitis 12.87 9.94 3 132279 10471 63346269
Hydronephrosis 12.78 9.94 50 132232 10612 63346128
Oxygen therapy 12.75 9.94 19 132263 2159 63354581
Orthopnoea 12.59 9.94 35 132247 6226 63350514
Blood immunoglobulin G increased 12.56 9.94 20 132262 2407 63354333
Infantile apnoea 12.53 9.94 13 132269 1020 63355720
Radiculopathy 12.53 9.94 43 132239 8568 63348172
Disseminated intravascular coagulation 12.42 9.94 75 132207 18976 63337764
Cyst 12.34 9.94 7 132275 14092 63342648
Therapy non-responder 12.32 9.94 100 132182 75801 63280939
Atrioventricular block second degree 12.30 9.94 26 132256 3888 63352852
Sinoatrial block 12.29 9.94 12 132270 876 63355864
Polyarthritis 12.28 9.94 3 132279 10143 63346597
Lung infiltration 12.16 9.94 61 132221 14402 63342338
Upper gastrointestinal haemorrhage 12.15 9.94 74 132208 18778 63337962
Ventricular fibrillation 12.14 9.94 53 132229 11814 63344926
Serotonin syndrome 12.13 9.94 26 132256 28656 63328084
Blood pressure diastolic increased 12.04 9.94 3 132279 10007 63346733
Transient ischaemic attack 12.03 9.94 126 132156 37627 63319113
Central nervous system injury 12.00 9.94 6 132276 145 63356595
Necrotising colitis 12 9.94 10 132272 593 63356147
Vascular device infection 11.97 9.94 38 132244 7274 63349466
Neonatal infection 11.93 9.94 6 132276 147 63356593
Gout 11.89 9.94 57 132225 13214 63343526
Hepatic function abnormal 11.86 9.94 124 132158 37018 63319722
Hyperaldosteronism 11.81 9.94 7 132275 239 63356501
Retinal ischaemia 11.77 9.94 8 132274 348 63356392
Unevaluable event 11.76 9.94 161 132121 51225 63305515
Lip dry 11.75 9.94 9 132273 15461 63341279
Therapy cessation 11.75 9.94 29 132253 30428 63326312
Disease progression 11.74 9.94 337 131945 122421 63234319
Red blood cell count decreased 11.73 9.94 133 132149 40512 63316228
Polyneuropathy 11.72 9.94 8 132274 14581 63342159
Polymyalgia rheumatica 11.70 9.94 25 132257 3766 63352974
Product use in unapproved indication 11.64 9.94 284 131998 178796 63177944
Dry mouth 11.56 9.94 105 132177 77758 63278982
Nausea 11.50 9.94 1985 130297 852486 62504254
Chronic respiratory failure 11.42 9.94 17 132265 1930 63354810
Paracentesis 11.40 9.94 12 132270 958 63355782
Vascular pseudoaneurysm 11.39 9.94 15 132267 1519 63355221
Abortion incomplete complicated 11.39 9.94 3 132279 9 63356731
Intestinal polyp 11.38 9.94 15 132267 1520 63355220
Vascular access malfunction 11.38 9.94 4 132278 38 63356702
Injection site warmth 11.34 9.94 9 132273 15186 63341554
Cerebrovascular accident 11.30 9.94 300 131982 107724 63249016
Serratia sepsis 11.29 9.94 5 132277 91 63356649
Product substitution issue 11.29 9.94 10 132272 15986 63340754
Urinary tract obstruction 11.16 9.94 18 132264 2190 63354550
Right ventricular dilatation 11.07 9.94 14 132268 1362 63355378
Electrocardiogram U wave present 11.05 9.94 5 132277 96 63356644
Rectal haemorrhage 10.97 9.94 153 132129 48877 63307863
Food allergy 10.96 9.94 5 132277 11396 63345344
Somnolence 10.94 9.94 466 131816 178219 63178521
Panniculitis 10.94 9.94 5 132277 11380 63345360
Blood glucose decreased 10.93 9.94 78 132204 20874 63335866
Electrocardiogram Q wave abnormal 10.92 9.94 6 132276 177 63356563
Haematotoxicity 10.92 9.94 3 132279 9373 63347367
Hypophosphataemia 10.91 9.94 50 132232 11376 63345364
Shock 10.91 9.94 85 132197 23378 63333362
Hyperdynamic left ventricle 10.83 9.94 6 132276 180 63356560
Alanine aminotransferase increased 10.80 9.94 288 131994 103482 63253258
Injection site rash 10.78 9.94 14 132268 18795 63337945
Stupor 10.76 9.94 26 132256 4249 63352491
Haemodialysis 10.76 9.94 42 132240 8905 63347835
Blood aldosterone abnormal 10.70 9.94 4 132278 46 63356694
Ataxia 10.67 9.94 61 132221 15134 63341606
Left ventricular failure 10.66 9.94 31 132251 5656 63351084
Blood loss anaemia 10.62 9.94 42 132240 8959 63347781
Cytotoxic oedema 10.62 9.94 6 132276 187 63356553
Staphylococcal infection 10.59 9.94 132 132150 41124 63315616
Hernia 10.55 9.94 53 132229 12521 63344219
Pharyngitis 10.54 9.94 16 132266 20127 63336613
Lactic acidosis 10.48 9.94 124 132158 38163 63318577
Acute pulmonary oedema 10.39 9.94 39 132243 8119 63348621
Left ventricular dysfunction 10.39 9.94 51 132231 11937 63344803
Ischaemic hepatitis 10.35 9.94 17 132265 2099 63354641
Obstructive airways disorder 10.30 9.94 17 132265 20682 63336058
Pulmonary arterial pressure increased 10.30 9.94 23 132259 3572 63353168
Heart rate abnormal 10.29 9.94 28 132254 4919 63351821
Osteonecrosis of jaw 10.28 9.94 38 132244 35085 63321655
Oral candidiasis 10.28 9.94 82 132200 22716 63334024
Potassium wasting nephropathy 10.26 9.94 4 132278 52 63356688
Sinus tachycardia 10.24 9.94 86 132196 24182 63332558
Sinus node dysfunction 10.23 9.94 27 132255 4658 63352082
Chills 10.23 9.94 309 131973 113069 63243671
Extravasation 10.21 9.94 18 132264 2354 63354386
Hypercholesterolaemia 10.18 9.94 18 132264 21316 63335424
Schizophrenia 10.15 9.94 4 132278 9948 63346792
Acute myocardial infarction 10.14 9.94 107 132175 32017 63324723
Differentiation syndrome 10.13 9.94 12 132270 1091 63355649
Dry eye 10.13 9.94 47 132235 40714 63316026
Renal impairment 10.01 9.94 248 132034 88107 63268633
Multiple organ dysfunction syndrome 9.97 9.94 170 132112 56582 63300158

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 178.49 10.03 531 82814 456220 34417366
Appendicolith 165.12 10.03 148 83197 8453 34865133
Cardiogenic shock 152.32 10.03 247 83098 26371 34847215
Hypokalaemia 152.10 10.03 390 82955 57824 34815762
Drug abuse 150.96 10.03 27 83318 99069 34774517
Cardiac failure congestive 115.51 10.03 448 82897 82822 34790764
Appendicitis 114.18 10.03 158 83187 14649 34858937
Ascites 110.43 10.03 301 83044 46270 34827316
Myelosuppression 107.81 10.03 177 83168 19088 34854498
Abdominal distension 101.81 10.03 339 83006 58153 34815433
Sepsis 89.95 10.03 692 82653 165869 34707717
Hypotension 83.54 10.03 851 82494 220798 34652788
Ventricular fibrillation 79.77 10.03 172 83173 22782 34850804
Stress 77.85 10.03 202 83143 30145 34843441
Heparin-induced thrombocytopenia 74.88 10.03 79 83266 5516 34868070
Cytokine release syndrome 71.16 10.03 164 83181 22713 34850873
Hyperkalaemia 69.82 10.03 339 83006 69050 34804536
Multiple organ dysfunction syndrome 67.89 10.03 361 82984 76205 34797381
Atrial fibrillation 61.32 10.03 500 82845 121893 34751693
Blood phosphorus increased 60.43 10.03 83 83262 7638 34865948
Blood potassium decreased 59.70 10.03 132 83213 17783 34855803
Tachypnoea 58.66 10.03 133 83212 18219 34855367
Therapeutic product effect incomplete 56.24 10.03 25 83320 50516 34823070
Lung consolidation 54.48 10.03 69 83276 5867 34867719
Treatment failure 53.71 10.03 22 83323 46675 34826911
Hypervolaemia 53.45 10.03 134 83211 19575 34854011
Soft tissue mass 47.84 10.03 30 83315 989 34872597
Rales 46.36 10.03 84 83261 9799 34863787
Incision site pain 46.32 10.03 37 83308 1801 34871785
Suicide attempt 45.69 10.03 18 83327 39098 34834488
Spinal muscular atrophy 45.09 10.03 21 83324 375 34873211
Multimorbidity 44.90 10.03 28 83317 914 34872672
Blood urea increased 44.20 10.03 166 83179 30198 34843388
Cardiac failure 44.18 10.03 370 82975 90878 34782708
Rheumatoid arthritis 44.00 10.03 18 83327 38220 34835366
Off label use 43.69 10.03 721 82624 418803 34454783
Hyponatraemia 42.02 10.03 339 83006 82352 34791234
Arthralgia 41.89 10.03 236 83109 169805 34703781
Toxicity to various agents 41.69 10.03 293 83052 200069 34673517
Oedema peripheral 40.78 10.03 451 82894 119361 34754225
Dyspnoea 40.36 10.03 1179 82166 375603 34497983
Injection site pain 39.31 10.03 22 83323 38983 34834603
Toxic epidermal necrolysis 39.01 10.03 127 83218 21519 34852067
Hypoglycaemia 38.84 10.03 243 83102 54397 34819189
Oesophageal perforation 38.75 10.03 28 83317 1171 34872415
Meningitis aseptic 38.73 10.03 43 83302 3181 34870405
Superinfection 38.12 10.03 38 83307 2481 34871105
International normalised ratio increased 37.81 10.03 217 83128 47110 34826476
Pneumonia 36.20 10.03 1125 82220 361502 34512084
Right ventricular failure 35.43 10.03 70 83275 8714 34864872
Constipation 34.33 10.03 487 82858 136495 34737091
Administration site extravasation 34.03 10.03 20 83325 585 34873001
Headache 33.62 10.03 311 83034 200324 34673262
Motor neurone disease 31.50 10.03 18 83327 499 34873087
Burkholderia test positive 31.05 10.03 23 83322 1000 34872586
Diaphragmatic spasm 29.79 10.03 11 83334 105 34873481
Stoma closure 29.32 10.03 14 83331 265 34873321
Intentional product use issue 29.01 10.03 62 83283 59754 34813832
Acute respiratory failure 28.88 10.03 148 83197 30780 34842806
Respiratory failure 28.81 10.03 390 82955 108182 34765404
Bone marrow failure 28.74 10.03 142 83203 29111 34844475
Faecal volume decreased 28.57 10.03 11 83334 119 34873467
Ventricular tachycardia 27.53 10.03 131 83214 26448 34847138
Dehydration 27.51 10.03 449 82896 129520 34744066
Overdose 27.22 10.03 118 83227 90941 34782645
Serotonin syndrome 27.13 10.03 7 83338 19926 34853660
Pneumococcal sepsis 26.78 10.03 22 83323 1115 34872471
Psoriasis 26.58 10.03 32 83313 38780 34834806
Loss of personal independence in daily activities 26.50 10.03 24 83321 33155 34840431
Sputum increased 25.74 10.03 30 83315 2340 34871246
Lymphadenectomy 25.00 10.03 14 83331 373 34873213
Blood pressure fluctuation 24.37 10.03 15 83330 25234 34848352
Hypoxia 24.35 10.03 219 83126 54876 34818710
Pulse absent 24.32 10.03 47 83298 5756 34867830
Drug resistance 24.20 10.03 16 83329 25911 34847675
Increased bronchial secretion 24.18 10.03 26 83319 1855 34871731
Haemoglobin decreased 23.64 10.03 412 82933 120360 34753226
Drug interaction 23.52 10.03 388 82957 225558 34648028
Blood bilirubin increased 23.38 10.03 164 83181 38132 34835454
Hypernatraemia 23.31 10.03 58 83287 8432 34865154
Mental status changes 23.20 10.03 163 83182 37920 34835666
Acute kidney injury 23.09 10.03 917 82428 304071 34569515
White blood cell count decreased 22.96 10.03 337 83008 95108 34778478
Musculoskeletal stiffness 22.95 10.03 48 83297 46632 34826954
Glomerular filtration rate 22.70 10.03 9 83336 106 34873480
Blood uric acid increased 22.58 10.03 62 83283 9562 34864024
Sedation 22.42 10.03 11 83334 20995 34852591
Disease complication 22.30 10.03 30 83315 2706 34870880
Ventricular extrasystoles 22.13 10.03 71 83274 11937 34861649
Suicidal ideation 22.06 10.03 39 83306 40349 34833237
Atelectasis 21.84 10.03 92 83253 17635 34855951
Asthenia 21.84 10.03 751 82594 244500 34629086
Transient aphasia 21.77 10.03 13 83332 392 34873194
Transplant failure 21.73 10.03 34 83311 3519 34870067
Lymphocyte count decreased 21.64 10.03 109 83236 22513 34851073
Red blood cells urine positive 21.51 10.03 24 83321 1785 34871801
Chills 21.03 10.03 290 83055 80753 34792833
Troponin T increased 20.87 10.03 27 83318 2344 34871242
Product dose omission issue 20.70 10.03 184 83161 119527 34754059
Fluid retention 20.63 10.03 122 83223 26765 34846821
Product use in unapproved indication 20.58 10.03 180 83165 117319 34756267
Intentional self-injury 20.42 10.03 4 83341 13767 34859819
Therapeutic product effect decreased 20.42 10.03 32 83313 34711 34838875
Inappropriate schedule of product administration 20.32 10.03 78 83267 62218 34811368
Resuscitation 20.31 10.03 21 83324 1432 34872154
Pulmonary arterial hypertension 20.21 10.03 56 83289 8683 34864903
Inflammatory marker increased 20.19 10.03 40 83305 4988 34868598
Pulmonary hypertension 20.14 10.03 101 83244 20823 34852763
Lung infiltration 19.99 10.03 72 83273 12833 34860753
Hyperphosphataemia 19.91 10.03 37 83308 4400 34869186
Cardiomegaly 19.71 10.03 81 83264 15357 34858229
Endotracheal intubation 19.68 10.03 30 83315 3035 34870551
Myasthenia gravis 19.67 10.03 48 83297 6892 34866694
Gastrointestinal haemorrhage 19.58 10.03 308 83037 88169 34785417
Mobility decreased 19.42 10.03 26 83319 30102 34843484
Abdominal pain 19.38 10.03 519 82826 163099 34710487
Atrial flutter 19.32 10.03 81 83264 15493 34858093
Lower respiratory tract infection bacterial 19.23 10.03 13 83332 488 34873098
Bronchial disorder 19.11 10.03 20 83325 1383 34872203
Drug reaction with eosinophilia and systemic symptoms 18.84 10.03 31 83314 32981 34840605
Product use issue 18.84 10.03 82 83263 63134 34810452
Cardiac arrest 18.79 10.03 328 83017 95831 34777755
Compartment syndrome 18.62 10.03 29 83316 2989 34870597
Prostate cancer 18.48 10.03 42 83303 39607 34833979
Aggression 18.38 10.03 41 83304 38923 34834663
Insomnia 18.27 10.03 159 83186 103748 34769838
Metabolic alkalosis 18.00 10.03 20 83325 1481 34872105
Angioedema 17.90 10.03 39 83306 37335 34836251
Electrocardiogram T wave amplitude decreased 17.86 10.03 11 83334 351 34873235
Peri-implantitis 17.86 10.03 8 83337 130 34873456
Neutrophil count decreased 17.65 10.03 193 83152 50911 34822675
Blood creatinine increased 17.51 10.03 321 83024 94655 34778931
Myalgia 17.45 10.03 123 83222 83987 34789599
Infusion site necrosis 17.41 10.03 5 83340 19 34873567
Ischaemic cerebral infarction 17.39 10.03 18 83327 1229 34872357
Exercise tolerance decreased 16.97 10.03 38 83307 5160 34868426
Tumour lysis syndrome 16.89 10.03 83 83262 16976 34856610
Oedema 16.84 10.03 175 83170 45566 34828020
Cardiomyopathy 16.80 10.03 82 83263 16726 34856860
Obstructive airways disorder 16.71 10.03 8 83337 15486 34858100
Pleural effusion 16.60 10.03 280 83065 81266 34792320
Ileus 16.14 10.03 80 83265 16419 34857167
Atrial enlargement 15.82 10.03 13 83332 659 34872927
Therapeutic product effect prolonged 15.67 10.03 9 83336 252 34873334
Plasma cell myeloma 15.56 10.03 161 83184 41876 34831710
Oropharyngeal pain 15.41 10.03 39 83306 35446 34838140
Vocal cord paralysis 15.41 10.03 15 83330 951 34872635
Therapeutic response decreased 15.39 10.03 29 83316 29284 34844302
Chest X-ray abnormal 15.32 10.03 33 83312 4365 34869221
Pulmonary oedema 15.28 10.03 177 83168 47352 34826234
Respiratory tract infection bacterial 15.23 10.03 20 83325 1762 34871824
Disturbance in attention 15.14 10.03 24 83321 25921 34847665
Type IIa hyperlipidaemia 15.11 10.03 8 83337 190 34873396
Platelet count decreased 15.10 10.03 383 82962 119334 34754252
Urticaria 15.10 10.03 87 83258 62290 34811296
Device related infection 15.07 10.03 81 83264 17156 34856430
Visual acuity reduced 15.03 10.03 10 83335 16139 34857447
Hypophosphataemia 14.99 10.03 59 83286 10967 34862619
Oesophagitis 14.94 10.03 67 83278 13194 34860392
Product substitution issue 14.82 10.03 3 83342 10092 34863494
Metabolic disorder 14.77 10.03 32 83313 4251 34869335
Depression 14.76 10.03 154 83191 96944 34776642
Shoshin beriberi 14.74 10.03 6 83339 76 34873510
Sensory integrative dysfunction 14.65 10.03 5 83340 37 34873549
Drug dependence 14.52 10.03 22 83323 24195 34849391
Emotional disorder of childhood 14.32 10.03 5 83340 40 34873546
Epididymitis 14.30 10.03 23 83322 2436 34871150
Blood glucose increased 14.28 10.03 231 83114 66487 34807099
Joint swelling 14.24 10.03 84 83261 59806 34813780
Anaemia 13.95 10.03 685 82660 232650 34640936
Chronic obstructive pulmonary disease 13.91 10.03 178 83167 48740 34824846
Psoriatic arthropathy 13.90 10.03 16 83329 19782 34853804
Cardiac dysfunction 13.78 10.03 22 83323 2316 34871270
Interstitial lung disease 13.77 10.03 95 83250 65187 34808399
Granulocyte count decreased 13.65 10.03 13 83332 802 34872784
Body temperature decreased 13.65 10.03 7 83338 13027 34860559
Cytomegalovirus infection 13.59 10.03 26 83319 26109 34847477
Scrotal oedema 13.35 10.03 19 83326 1807 34871779
Prothrombin time prolonged 13.33 10.03 51 83294 9355 34864231
Arthritis 13.19 10.03 35 83310 31311 34842275
Vasoplegia syndrome 13.11 10.03 19 83326 1837 34871749
Intentional product misuse 13.08 10.03 60 83285 45551 34828035
Arrhythmia supraventricular 12.97 10.03 16 83329 1324 34872262
Right ventricular dysfunction 12.96 10.03 15 83330 1161 34872425
Arthropathy 12.95 10.03 28 83317 26879 34846707
Cognitive disorder 12.88 10.03 31 83314 28662 34844924
Protein urine present 12.59 10.03 34 83311 5194 34868392
Renal tubular acidosis 12.56 10.03 21 83324 2298 34871288
Failure to thrive 12.49 10.03 47 83298 8554 34865032
Amnesia 12.49 10.03 28 83317 26535 34847051
Posthaemorrhagic hydrocephalus 12.27 10.03 6 83339 120 34873466
Hyperglycaemia 12.23 10.03 146 83199 39334 34834252
Depressed mood 12.12 10.03 17 83328 19300 34854286
Cardiac pacemaker evaluation 12.09 10.03 6 83339 124 34873462
Catheter site infection 12.09 10.03 22 83323 2575 34871011
Eosinophilia 12.04 10.03 28 83317 26194 34847392
International normalised ratio fluctuation 11.99 10.03 15 83330 1259 34872327
Haemoptysis 11.99 10.03 132 83213 34874 34838712
Immune effector cell-associated neurotoxicity syndrome 11.96 10.03 27 83318 3686 34869900
Hyperinsulinaemia 11.96 10.03 5 83340 68 34873518
Clostridium difficile colitis 11.83 10.03 71 83274 15659 34857927
Drug therapy 11.66 10.03 14 83331 1127 34872459
Blood potassium increased 11.49 10.03 73 83272 16422 34857164
Blood chloride decreased 11.48 10.03 27 83318 3786 34869800
Lactobacillus test positive 11.45 10.03 4 83341 32 34873554
Cortical visual impairment 11.35 10.03 4 83341 33 34873553
Blood albumin decreased 11.34 10.03 63 83282 13509 34860077
Immunosuppressant drug level increased 11.34 10.03 36 83309 6019 34867567
Blood gases abnormal 11.30 10.03 8 83337 324 34873262
Biliary obstruction 11.22 10.03 22 83323 2723 34870863
Bacteraemia 11.20 10.03 83 83262 19634 34853952
Alkalosis 11.13 10.03 6 83339 148 34873438
Intentional overdose 11.06 10.03 60 83285 43614 34829972
Tendonitis 11.01 10.03 4 83341 9136 34864450
Foetal exposure during pregnancy 11.00 10.03 50 83295 38051 34835535
Drug chemical incompatibility 10.99 10.03 3 83342 9 34873577
General physical health deterioration 10.94 10.03 391 82954 127878 34745708
Haematotoxicity 10.92 10.03 3 83342 8191 34865395
Face oedema 10.89 10.03 7 83338 11509 34862077
Congestive cardiomyopathy 10.88 10.03 41 83304 7469 34866117
Squamous cell carcinoma 10.82 10.03 7 83338 11468 34862118
Memory impairment 10.71 10.03 60 83285 43258 34830328
Epilepsy 10.65 10.03 22 83323 21473 34852113
Hepatotoxicity 10.64 10.03 22 83323 21463 34852123
Asthma 10.59 10.03 59 83286 42597 34830989
Intracardiac mass 10.58 10.03 6 83339 164 34873422
Anxiety 10.56 10.03 170 83175 99258 34774328
Polyneuropathy 10.50 10.03 12 83333 14884 34858702
Dry mouth 10.44 10.03 114 83231 30051 34843535
Febrile neutropenia 10.43 10.03 412 82933 136437 34737149
Mood swings 10.33 10.03 3 83342 7898 34865688
Metamyelocyte percentage increased 10.32 10.03 3 83342 12 34873574
Alveolar lung disease 10.22 10.03 8 83337 378 34873208
Mental impairment 10.14 10.03 6 83339 10316 34863270
Aspartate aminotransferase increased 10.12 10.03 222 83123 67561 34806025
Product prescribing error 10.11 10.03 25 83320 22902 34850684
Altered state of consciousness 10.07 10.03 25 83320 22868 34850718
Limb discomfort 10.07 10.03 7 83338 11040 34862546
Pathogen resistance 10.07 10.03 5 83340 9477 34864109
Lymphoma 10.04 10.03 9 83336 12498 34861088

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myelosuppression 640.05 9.79 606 177633 39690 79526459
Hypokalaemia 376.34 9.79 927 177312 143113 79423036
Drug ineffective 369.24 9.79 1216 177023 1079697 78486452
Cardiac failure congestive 250.74 9.79 794 177445 141608 79424541
Hyperkalaemia 247.23 9.79 686 177553 113712 79452437
Hand deformity 216.37 9.79 3 178236 103916 79462233
Sepsis 205.53 9.79 1163 177076 268265 79297884
Drug abuse 201.27 9.79 57 178182 162634 79403515
Joint swelling 195.53 9.79 214 178025 288432 79277717
Hypervolaemia 183.82 9.79 337 177902 42353 79523796
Rheumatoid arthritis 180.80 9.79 122 178117 208348 79357801
Atrial fibrillation 177.29 9.79 893 177346 196993 79369156
Arthralgia 175.11 9.79 672 177567 571131 78995018
Arthropathy 172.82 9.79 90 178149 177021 79389128
Appendicolith 172.05 9.79 147 178092 8404 79557745
Cardiogenic shock 170.62 9.79 323 177916 41591 79524558
Cytokine release syndrome 170.16 9.79 296 177943 35702 79530447
Systemic lupus erythematosus 168.48 9.79 33 178206 121116 79445033
Hypotension 164.25 9.79 1603 176636 438714 79127435
Blood potassium decreased 157.60 9.79 332 177907 46180 79519969
Pneumonia 154.88 9.79 2198 176041 658048 78908101
Pericarditis 154.55 9.79 24 178215 104212 79461937
Therapeutic product effect decreased 154.42 9.79 87 178152 163776 79402373
Musculoskeletal stiffness 148.30 9.79 105 178134 174903 79391246
Bone marrow failure 147.41 9.79 342 177897 50765 79515384
Colitis microscopic 141.31 9.79 146 178093 10622 79555527
Contraindicated product administered 134.16 9.79 94 178145 157444 79408705
Glossodynia 133.87 9.79 33 178206 103304 79462845
White blood cell count decreased 133.84 9.79 798 177441 187490 79378659
Wound 129.09 9.79 49 178190 116130 79450019
Ascites 128.96 9.79 417 177822 75145 79491004
Duodenal ulcer perforation 126.11 9.79 5 178234 66206 79499943
Alopecia 123.64 9.79 204 178035 231151 79334998
Hypoxia 119.13 9.79 502 177737 102741 79463408
Helicobacter infection 118.40 9.79 10 178229 69694 79496455
Drug intolerance 117.44 9.79 260 177979 263859 79302290
Oedema peripheral 116.73 9.79 963 177276 251325 79314824
Acute kidney injury 114.80 9.79 1712 176527 517692 79048457
Acute respiratory failure 114 9.79 342 177897 59199 79506950
Appendicitis 112.97 9.79 182 178057 20612 79545537
Heparin-induced thrombocytopenia 108.94 9.79 121 178118 9561 79556588
Respiratory failure 105.31 9.79 729 177510 180182 79385967
Pulmonary hypertension 104.45 9.79 289 177950 47791 79518358
Dehydration 103.08 9.79 925 177314 247262 79318887
Right ventricular failure 101.78 9.79 186 178053 23311 79542838
Abdominal discomfort 94.95 9.79 268 177971 250459 79315690
Neutrophil count decreased 94.85 9.79 439 177800 93520 79472629
Muscle injury 94.81 9.79 3 178236 48558 79517591
Hyponatraemia 94.44 9.79 701 177538 177147 79389002
Intentional product use issue 94.12 9.79 121 178118 151991 79414158
Ventricular fibrillation 93.54 9.79 215 178024 31711 79534438
Off label use 93.10 9.79 1448 176791 905767 78660382
Pain 92.61 9.79 1067 177172 702735 78863414
Hypoglycaemia 89.85 9.79 457 177782 101137 79465012
Lower respiratory tract infection 89.41 9.79 94 178145 129126 79437023
Blood urea increased 86.65 9.79 273 177966 48517 79517632
Treatment failure 84.10 9.79 158 178081 170328 79395821
Glaucoma 83.79 9.79 155 178084 19606 79546543
Product use issue 81.87 9.79 221 178018 209601 79356548
Toxicity to various agents 81.65 9.79 579 177660 420961 79145188
Discomfort 79.71 9.79 98 178141 125519 79440630
Folliculitis 79.30 9.79 14 178225 55366 79510783
Irritable bowel syndrome 78.45 9.79 21 178218 62220 79503929
Hypersensitivity 78.25 9.79 311 177928 261928 79304221
Anaemia 78.21 9.79 1413 176826 443602 79122547
Pneumonia aspiration 76.75 9.79 325 177914 66642 79499507
Injection site pain 76.54 9.79 107 178132 129731 79436418
Gastrointestinal haemorrhage 76.00 9.79 578 177661 147141 79419008
Nasopharyngitis 75.81 9.79 301 177938 253580 79312569
Pulmonary arterial hypertension 74.42 9.79 183 178056 28183 79537966
International normalised ratio increased 73.44 9.79 379 177860 84342 79481807
Multiple organ dysfunction syndrome 73.18 9.79 490 177749 119756 79446393
Dyspnoea 72.54 9.79 2463 175776 854562 78711587
Synovitis 72.33 9.79 142 178097 150592 79415557
Cardiac arrest 72.21 9.79 643 177596 171453 79394696
Abdominal distension 71.87 9.79 486 177753 119164 79446985
Tachypnoea 69.91 9.79 193 178046 31870 79534279
Impaired healing 69.84 9.79 56 178183 87599 79478550
Pleural effusion 69.55 9.79 559 177680 144703 79421446
Hepatic enzyme increased 69.25 9.79 195 178044 182415 79383734
Drug hypersensitivity 66.25 9.79 394 177845 298522 79267627
Cardiac failure 66.23 9.79 581 177658 154261 79411888
Febrile neutropenia 65.11 9.79 796 177443 230203 79335946
Plasma cell myeloma 64.58 9.79 263 177976 52996 79513153
Blood phosphorus increased 63.78 9.79 96 178143 10251 79555898
Toxic epidermal necrolysis 63.76 9.79 232 178007 44349 79521800
Blood bilirubin increased 62.85 9.79 304 177935 65928 79500221
Platelet count decreased 61.62 9.79 686 177553 193978 79372171
Haemoglobin decreased 60.70 9.79 761 177478 221358 79344791
Fluid retention 60.30 9.79 312 177927 69497 79496652
Psoriasis 59.94 9.79 67 178172 89520 79476629
Bronchitis 59.44 9.79 497 177742 130147 79436002
Rash 58.15 9.79 926 177313 577432 78988717
Incision site pain 57.65 9.79 49 178190 2781 79563368
Product use in unapproved indication 56.52 9.79 328 177911 250031 79316118
Ill-defined disorder 56.46 9.79 39 178200 65836 79500313
Psoriatic arthropathy 55.93 9.79 55 178184 77944 79488205
Mental status changes 55.59 9.79 296 177943 66663 79499486
Diverticulitis 54.24 9.79 225 178014 45711 79520438
Infusion related reaction 53.94 9.79 298 177941 229939 79336210
Lung consolidation 53.72 9.79 82 178157 8865 79557284
Pulmonary oedema 53.30 9.79 359 177880 87895 79478254
Therapeutic product effect incomplete 53.14 9.79 152 178087 141493 79424656
Atrial flutter 53.05 9.79 136 178103 21489 79544660
Inappropriate schedule of product administration 52.67 9.79 140 178099 133488 79432661
Headache 52.15 9.79 1090 177149 652682 78913467
Intentional self-injury 51.53 9.79 6 178233 32413 79533736
Chronic obstructive pulmonary disease 51.31 9.79 347 177892 85072 79481077
Suicidal ideation 51.17 9.79 57 178182 76283 79489866
Therapeutic response decreased 50.45 9.79 45 178194 66808 79499341
Hypernatraemia 49.92 9.79 104 178135 14347 79551802
Constipation 49.02 9.79 897 177342 282153 79283996
Injection site bruising 47.74 9.79 16 178223 40986 79525163
Spinal muscular atrophy 46.03 9.79 21 178218 382 79565767
Ventricular tachycardia 45.34 9.79 200 178039 41735 79524414
Blood pressure fluctuation 45.15 9.79 50 178189 67095 79499054
PO2 increased 44.13 9.79 33 178206 1555 79564594
Sopor 43.81 9.79 10 178229 33000 79533149
Soft tissue mass 43.20 9.79 30 178209 1258 79564891
Encephalopathy 43.02 9.79 278 177961 67119 79499030
Injection site swelling 42.99 9.79 26 178213 47106 79519043
Asthenia 42.46 9.79 1468 176771 510221 79055928
Multimorbidity 42.46 9.79 31 178208 1408 79564741
Cardiomegaly 41.88 9.79 142 178097 26210 79539939
Renal failure 41.37 9.79 655 177584 200313 79365836
Inflammation 41.04 9.79 93 178146 93660 79472489
Pulse absent 40.04 9.79 77 178162 10026 79556123
Swelling 39.80 9.79 302 177937 216409 79349740
Arthritis 39.02 9.79 129 178110 114751 79451398
C-reactive protein abnormal 38.40 9.79 31 178208 48336 79517813
Mobility decreased 38.27 9.79 142 178097 122033 79444116
Loss of personal independence in daily activities 37.80 9.79 111 178128 102469 79463680
Injection site reaction 37.72 9.79 40 178199 54745 79511404
Coagulopathy 37.63 9.79 170 178069 35836 79530313
Administration site extravasation 37.53 9.79 28 178211 1315 79564834
Rales 37.44 9.79 114 178125 19887 79546262
Hypomagnesaemia 37.32 9.79 205 178034 46706 79519443
Atelectasis 37.30 9.79 157 178082 32100 79534049
Blood alkaline phosphatase increased 37.26 9.79 257 177982 63407 79502742
Electrolyte imbalance 37.04 9.79 152 178087 30729 79535420
Renal ischaemia 36.49 9.79 26 178213 1136 79565013
Injection site erythema 36.36 9.79 75 178164 78122 79488027
PCO2 increased 35.73 9.79 31 178208 1809 79564340
Metabolic alkalosis 35.62 9.79 47 178192 4442 79561707
Blood magnesium decreased 35.60 9.79 99 178140 16413 79549736
Grip strength decreased 34.87 9.79 4 178235 21865 79544284
Thrombocytopenia 34.83 9.79 807 177432 264452 79301697
Non-cardiogenic pulmonary oedema 34.80 9.79 28 178211 1471 79564678
Blister 34.77 9.79 143 178096 119333 79446816
Infection 34.21 9.79 360 177879 241352 79324797
Gastrooesophageal reflux disease 34.16 9.79 370 177869 103876 79462273
Abdominal pain 34.14 9.79 1125 177114 388444 79177705
Blood creatinine increased 34.06 9.79 511 177728 154546 79411603
Drug reaction with eosinophilia and systemic symptoms 33.95 9.79 57 178182 64187 79501962
Oesophageal perforation 33.65 9.79 28 178211 1543 79564606
Aspartate aminotransferase increased 33.26 9.79 464 177775 138177 79427972
Osteoarthritis 33.25 9.79 93 178146 87216 79478933
Immune effector cell-associated neurotoxicity syndrome 32.88 9.79 52 178187 5796 79560353
Diabetes insipidus 32.87 9.79 49 178190 5188 79560961
Blood glucose increased 32.27 9.79 396 177843 114579 79451570
Fibromyalgia 32.26 9.79 59 178180 64281 79501868
Serotonin syndrome 31.99 9.79 32 178207 44995 79521154
Electrocardiogram abnormal 31.89 9.79 96 178143 16641 79549508
Knee arthroplasty 31.58 9.79 30 178209 43218 79522931
Coma 31.50 9.79 354 177885 100295 79465854
Granulocytopenia 31.32 9.79 75 178164 11356 79554793
Blood potassium increased 31.18 9.79 139 178100 29136 79537013
Hip arthroplasty 30.86 9.79 21 178218 35735 79530414
Maternal exposure during pregnancy 30.73 9.79 179 178060 136359 79429790
Vaginal flatulence 30.39 9.79 33 178206 2542 79563607
Suicide attempt 30.36 9.79 90 178149 82842 79483307
Diaphragmatic spasm 29.86 9.79 11 178228 112 79566037
Depressed mood 29.52 9.79 39 178200 48441 79517708
Stoma closure 28.82 9.79 14 178225 295 79565854
Vomiting 28.79 9.79 1789 176450 664039 78902110
Deep vein thrombosis 28.73 9.79 404 177835 120515 79445634
Pregnancy 28.71 9.79 12 178227 26839 79539310
Gastrointestinal disorder 28.69 9.79 158 178081 122047 79444102
Generalised oedema 28.67 9.79 117 178122 23592 79542557
Failure to thrive 28.55 9.79 74 178165 11770 79554379
Lung infiltration 28.45 9.79 114 178125 22798 79543351
Rheumatoid nodule 28.29 9.79 3 178236 17435 79548714
Tachycardia 28.22 9.79 556 177683 177212 79388937
Urticaria 28.20 9.79 271 177968 184930 79381219
Hyperglycaemia 28.05 9.79 260 177979 70075 79496074
Calcium deficiency 27.97 9.79 20 178219 879 79565270
Fatigue 27.86 9.79 1749 176490 927978 78638171
Motor neurone disease 27.31 9.79 17 178222 591 79565558
Bacteraemia 27.17 9.79 145 178094 32679 79533470
Oedema 27.00 9.79 396 177843 119184 79446965
Asthma 26.85 9.79 184 178055 134911 79431238
Joint range of motion decreased 26.84 9.79 21 178218 33261 79532888
Cor pulmonale 26.65 9.79 29 178210 2239 79563910
Macular degeneration 26.64 9.79 70 178169 11226 79554923
Adverse drug reaction 26.57 9.79 69 178170 66323 79499826
Cardiac dysfunction 26.48 9.79 39 178200 4085 79562064
Granulocyte count decreased 26.44 9.79 26 178213 1782 79564367
Transfusion 26.38 9.79 106 178133 21224 79544925
Ileus 26.09 9.79 122 178117 26089 79540060
Prothrombin time prolonged 25.92 9.79 90 178149 16809 79549340
Septic shock 25.92 9.79 402 177837 122399 79443750
Cardiac failure acute 25.80 9.79 97 178142 18832 79547317
Chills 25.71 9.79 502 177737 159732 79406417
Sedation 25.65 9.79 48 178191 51847 79514302
Paraesthesia oral 25.53 9.79 102 178137 20369 79545780
Bradycardia 25.36 9.79 435 177804 135122 79431027
Atrial enlargement 25.32 9.79 20 178219 1023 79565126
Sleep disorder 25.27 9.79 102 178137 85575 79480574
Sinusitis 24.96 9.79 298 177941 195203 79370946
Tendonitis 24.92 9.79 11 178228 23819 79542330
Faecal volume decreased 24.89 9.79 11 178228 185 79565964
Activated partial thromboplastin time prolonged 24.69 9.79 79 178160 14149 79552000
Pneumococcal sepsis 24.49 9.79 24 178215 1638 79564511
Hypovolaemia 24.40 9.79 91 178148 17600 79548549
Wrong technique in product usage process 24.37 9.79 84 178155 73791 79492358
Blood albumin decreased 24.25 9.79 113 178126 24130 79542019
Malnutrition 24.08 9.79 107 178132 22395 79543754
Brain natriuretic peptide increased 23.96 9.79 58 178181 8842 79557307
Urine chloride decreased 23.73 9.79 9 178230 100 79566049
Clostridium difficile colitis 23.65 9.79 138 178101 32145 79534004
Small intestinal obstruction 23.62 9.79 122 178117 27150 79538999
Urinary tract infection 23.58 9.79 791 177448 273721 79292428
Completed suicide 23.46 9.79 397 177842 245370 79320779
Full blood count decreased 23.24 9.79 120 178119 26699 79539450
Alkalosis 23.17 9.79 15 178224 559 79565590
Stomatitis 23.09 9.79 213 178026 146544 79419605
Paraesthesia 22.80 9.79 268 177971 176055 79390094
Obstructive airways disorder 22.76 9.79 22 178217 31437 79534712
Joint stiffness 22.73 9.79 35 178204 40795 79525354
Arrhythmia 22.70 9.79 223 178016 61049 79505100
Oesophageal pain 22.62 9.79 37 178202 4242 79561907
Interstitial lung disease 22.55 9.79 153 178086 112447 79453702
Hypophosphataemia 22.31 9.79 96 178143 19817 79546332
Drug eruption 22.29 9.79 40 178199 43895 79522254
Red blood cell sedimentation rate increased 22.27 9.79 43 178196 45899 79520250
Abortion spontaneous 22.09 9.79 20 178219 29487 79536662
Ventricular extrasystoles 22.08 9.79 95 178144 19609 79546540
Tumour lysis syndrome 22.07 9.79 109 178130 23830 79542319
Oxygen saturation abnormal 22.07 9.79 38 178201 4544 79561605
Syncope 22.03 9.79 541 177698 178908 79387241
Electrocardiogram T wave amplitude decreased 21.77 9.79 16 178223 734 79565415
Product substitution issue 21.74 9.79 9 178230 20247 79545902
Blood pressure diastolic abnormal 21.48 9.79 8 178231 19194 79546955
Haemoptysis 21.33 9.79 205 178034 55794 79510355
Blood pH decreased 21.30 9.79 38 178201 4673 79561476
Foetal death 21.21 9.79 52 178187 7992 79558157
Exercise tolerance decreased 21.17 9.79 56 178183 9015 79557134
Respiratory distress 20.97 9.79 211 178028 58128 79508021
Disturbance in attention 20.95 9.79 52 178187 50749 79515400
Multiple allergies 20.88 9.79 61 178178 10399 79555750
Acute left ventricular failure 20.87 9.79 23 178216 1801 79564348
Chronic sinusitis 20.53 9.79 70 178169 12956 79553193
Transient aphasia 20.50 9.79 13 178226 467 79565682
Supraventricular tachycardia 20.44 9.79 98 178141 21172 79544977
Glomerular filtration rate 20.39 9.79 9 178230 151 79565998
Resuscitation 20.37 9.79 26 178213 2378 79563771
Aggression 20.36 9.79 53 178186 50905 79515244
Peritonitis bacterial 20.27 9.79 57 178182 9510 79556639
Superinfection 20.22 9.79 38 178201 4864 79561285
Electrocardiogram T wave peaked 20.10 9.79 17 178222 958 79565191
Normal newborn 20.03 9.79 47 178192 7025 79559124
Hepatitis 20.02 9.79 61 178178 55666 79510483
Haematotoxicity 20.01 9.79 5 178234 15514 79550635
Skin reaction 19.99 9.79 80 178159 15988 79550161
Alanine aminotransferase increased 19.92 9.79 490 177749 162080 79404069
Blood bicarbonate decreased 19.89 9.79 39 178200 5152 79560997
Catheter management 19.81 9.79 32 178207 3631 79562518
Oesophageal spasm 19.80 9.79 31 178208 3425 79562724
Diarrhoea 19.80 9.79 2252 175987 878237 78687912
Oxygen consumption increased 19.80 9.79 38 178201 4941 79561208
Haematocrit decreased 19.80 9.79 217 178022 61095 79505054
Dementia 19.77 9.79 108 178131 24551 79541598
Oropharyngeal pain 19.77 9.79 153 178086 109200 79456949
Insomnia 19.69 9.79 408 177831 244762 79321387
Peripheral circulatory failure 19.66 9.79 18 178221 1128 79565021
Blood chloride decreased 19.62 9.79 51 178188 8126 79558023
Nail dystrophy 19.54 9.79 17 178222 996 79565153
Colitis 19.50 9.79 250 177989 73057 79493092
Posterior reversible encephalopathy syndrome 19.46 9.79 18 178221 26263 79539886
Night sweats 19.46 9.79 56 178183 52039 79514110
Disability 19.38 9.79 7 178232 17113 79549036
Blood pressure decreased 19.26 9.79 321 177918 99145 79467004
Impaired work ability 19.18 9.79 10 178229 19671 79546478
Procedural pain 19.12 9.79 102 178137 22982 79543167
Lymphoedema 18.95 9.79 66 178173 12347 79553802
Stress 18.91 9.79 266 177973 79346 79486803
Blood immunoglobulin M increased 18.79 9.79 19 178220 1347 79564802
Angioedema 18.57 9.79 97 178142 75938 79490211
Cardiomyopathy 18.55 9.79 119 178120 28655 79537494
Catheter site extravasation 18.54 9.79 12 178227 447 79565702
Right ventricular dysfunction 18.50 9.79 26 178213 2609 79563540
Congestive hepatopathy 18.45 9.79 35 178204 4512 79561637
Foot deformity 18.41 9.79 16 178223 24058 79542091
Hypoalbuminaemia 18.25 9.79 95 178144 21202 79544947
Weight increased 18.25 9.79 476 177763 276910 79289239
Burkholderia test positive 18.17 9.79 13 178226 572 79565577
Cytomegalovirus infection 18.10 9.79 43 178196 42601 79523548
Vertigo 18.09 9.79 86 178153 68996 79497153
Compartment syndrome 18.06 9.79 37 178202 5045 79561104
Muscle spasticity 18.02 9.79 13 178226 21462 79544687
Schizophrenia 18.02 9.79 6 178233 15434 79550715
Arrhythmia supraventricular 18.01 9.79 23 178216 2104 79564045
Lymphocyte count decreased 17.95 9.79 173 178066 47116 79519033
Transplant failure 17.94 9.79 35 178204 4606 79561543
Cellulitis 17.94 9.79 343 177896 108717 79457432
Hepatocellular injury 17.89 9.79 51 178188 47542 79518607
Ankylosing spondylitis 17.66 9.79 3 178236 12202 79553947
Hospice care 17.62 9.79 57 178182 10267 79555882
Anhedonia 17.60 9.79 73 178166 14825 79551324
Device related infection 17.51 9.79 134 178105 34160 79531989
Polyneuropathy 17.34 9.79 17 178222 24134 79542015
Accidental exposure to product 17.29 9.79 27 178212 31295 79534854
Osmotic demyelination syndrome 17.18 9.79 19 178220 1494 79564655
Prescribed overdose 17.05 9.79 37 178202 37846 79528303
Blood uric acid increased 17.01 9.79 67 178172 13293 79552856
Abdominal pain upper 16.94 9.79 376 177863 223443 79342706
Injection site pruritus 16.88 9.79 44 178195 42239 79523910
Respiratory tract infection bacterial 16.87 9.79 22 178217 2055 79564094
Hypercapnia 16.79 9.79 51 178188 8884 79557265
Overdose 16.79 9.79 300 177939 183906 79382243
Pulmonary fibrosis 16.78 9.79 47 178192 44065 79522084
Pneumonia staphylococcal 16.75 9.79 35 178204 4839 79561310
Hyperpyrexia 16.72 9.79 40 178199 6052 79560097
Epididymitis 16.55 9.79 21 178218 1909 79564240
Death 16.46 9.79 1475 176764 565039 79001110
Disease complication 16.44 9.79 35 178204 4902 79561247
Acne 16.42 9.79 22 178217 27168 79538981
Basal cell carcinoma 16.41 9.79 37 178202 37338 79528811
Lymphadenectomy 16.39 9.79 17 178222 1242 79564907
Intentional product misuse 16.35 9.79 135 178104 95030 79471119
Proctitis 16.35 9.79 41 178198 6391 79559758
Ischaemic cerebral infarction 16.31 9.79 24 178215 2511 79563638
Red blood cells urine positive 16.31 9.79 35 178204 4928 79561221
Product storage error 16.18 9.79 8 178231 16218 79549931
Dyspnoea exertional 16.13 9.79 279 177960 86794 79479355
Mental status changes postoperative 16.11 9.79 8 178231 177 79565972
Blood immunoglobulin A decreased 16.07 9.79 18 178221 1435 79564714
Pneumothorax spontaneous 16.06 9.79 18 178221 1436 79564713
Unresponsive to stimuli 16.02 9.79 193 178046 55595 79510554
Type IIa hyperlipidaemia 15.96 9.79 9 178230 260 79565889
Oxygen therapy 15.95 9.79 25 178214 2765 79563384
Facet joint syndrome 15.87 9.79 3 178236 11299 79554850
Dry eye 15.86 9.79 37 178202 36894 79529255
Osteonecrosis of jaw 15.76 9.79 47 178192 43179 79522970
Sputum increased 15.70 9.79 33 178206 4580 79561569
Body temperature decreased 15.65 9.79 30 178209 32115 79534034
Myasthenia gravis 15.62 9.79 55 178184 10344 79555805
Neuroglycopenia 15.59 9.79 11 178228 473 79565676
Therapeutic response shortened 15.55 9.79 8 178231 15855 79550294
Hyperphosphataemia 15.54 9.79 40 178199 6336 79559813
Blood pressure systolic increased 15.50 9.79 87 178152 66899 79499250
Miosis 15.42 9.79 8 178231 15781 79550368
Troponin T increased 15.40 9.79 28 178211 3494 79562655
Unevaluable event 15.39 9.79 191 178048 55394 79510755
Urine sodium decreased 15.38 9.79 9 178230 279 79565870
Oesophagitis 15.38 9.79 100 178139 24189 79541960
Pancytopenia 15.36 9.79 482 177757 165263 79400886
Radiculopathy 15.32 9.79 49 178190 8775 79557374
Increased bronchial secretion 15.25 9.79 27 178212 3300 79562849
Cardiac pacemaker evaluation 15.21 9.79 7 178232 130 79566019
Blood cholesterol increased 15.20 9.79 117 178122 83603 79482546
Supraventricular extrasystoles 15.17 9.79 42 178197 6945 79559204
Shoshin beriberi 15.11 9.79 6 178233 76 79566073
Torsade de pointes 15.10 9.79 84 178155 19228 79546921
Condition aggravated 15.06 9.79 942 177297 500182 79065967
Lip erosion 15.03 9.79 18 178221 1542 79564607
Left ventricular dysfunction 14.99 9.79 84 178155 19277 79546872
Cyanosis 14.93 9.79 102 178137 25080 79541069
Peri-implantitis 14.91 9.79 8 178231 209 79565940
Renal injury 14.85 9.79 76 178163 16851 79549298
Blood pressure diastolic increased 14.76 9.79 7 178232 14535 79551614
Left ventricular failure 14.67 9.79 51 178188 9530 79556619
Prostate cancer 14.55 9.79 33 178206 33235 79532914
Middle insomnia 14.46 9.79 9 178230 16060 79550089
Blood parathyroid hormone decreased 14.37 9.79 3 178236 10533 79555616
Thyroid disorder 14.36 9.79 66 178173 14013 79552136
COVID-19 pneumonia 14.33 9.79 112 178127 28737 79537412
Mitral valve incompetence 14.24 9.79 111 178128 28454 79537695
Migraine 14.19 9.79 126 178113 87367 79478782
Leukocytosis 14.12 9.79 154 178085 43301 79522848
Panniculitis 14.10 9.79 5 178234 12366 79553783
Female genital tract fistula 14.06 9.79 37 178202 5938 79560211
Akathisia 14.05 9.79 6 178233 13253 79552896
Cognitive disorder 14.01 9.79 95 178144 69831 79496318
Hepatotoxicity 13.99 9.79 63 178176 51289 79514860
Multiple sclerosis relapse 13.97 9.79 55 178184 46478 79519671
Pyrexia 13.90 9.79 1726 176513 676983 78889166
Pantoea agglomerans infection 13.85 9.79 6 178233 96 79566053
Skin candida 13.78 9.79 20 178219 2067 79564082
Poisoning 13.75 9.79 22 178217 25250 79540899
Eczema 13.74 9.79 46 178193 40772 79525377
Live birth 13.69 9.79 13 178226 18731 79547418
Rheumatic disorder 13.68 9.79 25 178214 3133 79563016
Intestinal polyp 13.66 9.79 20 178219 2084 79564065
Hypocalcaemia 13.59 9.79 171 178068 49753 79516396
Familial periodic paralysis 13.58 9.79 7 178232 168 79565981
Drug tolerance decreased 13.55 9.79 6 178233 12972 79553177
Electrocardiogram ST segment abnormal 13.55 9.79 17 178222 1528 79564621
Gastritis erosive 13.49 9.79 54 178185 10793 79555356
Cardiovascular insufficiency 13.42 9.79 24 178215 2957 79563192
Metabolic encephalopathy 13.41 9.79 48 178191 9099 79557050
Scrotal oedema 13.21 9.79 17 178222 1568 79564581
Chronic respiratory failure 13.18 9.79 24 178215 2998 79563151
Cardioactive drug level increased 13.17 9.79 27 178212 3682 79562467
Mood swings 13.15 9.79 15 178224 19865 79546284
Hepatic function abnormal 13.09 9.79 233 178006 72874 79493275
Atrioventricular block first degree 13.07 9.79 59 178180 12432 79553717
Extrapyramidal disorder 13.05 9.79 19 178220 22660 79543489
Bursitis 13.04 9.79 39 178200 35805 79530344
Hypophagia 13.04 9.79 157 178082 45210 79520939
Wheezing 12.97 9.79 183 178056 116481 79449668
Catheter site infection 12.97 9.79 39 178200 6756 79559393
Road traffic accident 12.86 9.79 52 178187 43612 79522537
Photosensitivity reaction 12.86 9.79 17 178222 21110 79545039
Drug chemical incompatibility 12.82 9.79 6 178233 116 79566033
N-terminal prohormone brain natriuretic peptide increased 12.81 9.79 31 178208 4724 79561425
Movement disorder 12.79 9.79 26 178213 27233 79538916
Electrocardiogram QT prolonged 12.79 9.79 278 177961 90108 79476041
Injection site haemorrhage 12.72 9.79 27 178212 27843 79538306
Lower respiratory tract infection bacterial 12.61 9.79 13 178226 943 79565206
Pulmonary arterial pressure increased 12.60 9.79 30 178209 4525 79561624
Device issue 12.60 9.79 26 178213 27082 79539067
Tonsillar haemorrhage 12.55 9.79 8 178231 290 79565859
Multiple drug therapy 12.54 9.79 28 178211 4050 79562099
Nodule 12.52 9.79 20 178219 22974 79543175
Paranoia 12.49 9.79 15 178224 19417 79546732
Injection site rash 12.48 9.79 13 178226 17941 79548208
Renal tubular acidosis 12.47 9.79 26 178213 3588 79562561
Cortical visual impairment 12.42 9.79 4 178235 26 79566123
Diuretic therapy 12.42 9.79 7 178232 202 79565947
Vasoplegia syndrome 12.39 9.79 26 178213 3604 79562545
Injection site warmth 12.38 9.79 9 178230 14798 79551351
Benign soft tissue neoplasm 12.37 9.79 6 178233 126 79566023
Myalgia 12.35 9.79 318 177921 185323 79380826
Adenocarcinoma 12.31 9.79 27 178212 3859 79562290
Skin disorder 12.30 9.79 37 178202 33906 79532243
Electrocardiogram U wave present 12.24 9.79 6 178233 129 79566020
Hallucination, auditory 12.24 9.79 17 178222 20676 79545473
Wrong product administered 12.13 9.79 46 178193 8966 79557183
Lip dry 12.09 9.79 10 178229 15408 79550741
Device related sepsis 12.09 9.79 36 178203 6204 79559945
Analgesic therapy 12.03 9.79 13 178226 996 79565153
Confusion postoperative 12.02 9.79 7 178232 215 79565934
Iatrogenic infection 12.02 9.79 5 178234 72 79566077
Pruritus 12.00 9.79 741 177498 393907 79172242
Pulmonary embolism 11.90 9.79 483 177756 171171 79394978
Skin dystrophy 11.89 9.79 5 178234 74 79566075
Nightmare 11.85 9.79 25 178214 25836 79540313
Gastric polyps 11.83 9.79 26 178213 3721 79562428
Herpes zoster 11.83 9.79 142 178097 92941 79473208
Ischaemic cardiomyopathy 11.82 9.79 41 178198 7654 79558495
Drug therapy 11.81 9.79 14 178225 1187 79564962
Blood pressure increased 11.79 9.79 371 177868 210989 79355160
Hyperlipidaemia 11.71 9.79 99 178140 25994 79540155
Gout 11.70 9.79 95 178144 24654 79541495
Thrombosis 11.69 9.79 258 177981 83842 79482307
Gait disturbance 11.63 9.79 364 177875 207142 79359007
Lactobacillus test positive 11.60 9.79 4 178235 33 79566116
Pneumonia klebsiella 11.59 9.79 31 178208 5023 79561126
Hyponatraemic encephalopathy 11.59 9.79 8 178231 332 79565817
Hyperaldosteronism 11.55 9.79 9 178230 451 79565698
Therapy cessation 11.53 9.79 44 178195 37518 79528631
Pain in extremity 11.51 9.79 682 177557 363856 79202293
Emphysema 11.50 9.79 69 178170 16231 79549918
Adverse event 11.47 9.79 83 178156 60131 79506018
Blood potassium abnormal 11.47 9.79 23 178216 3087 79563062
Salivary hypersecretion 11.44 9.79 9 178230 14215 79551934
Blood pressure systolic abnormal 11.42 9.79 13 178226 17234 79548915
Drug resistance 11.38 9.79 52 178187 42161 79523988
Catheter site haemorrhage 11.35 9.79 31 178208 5086 79561063
Throat irritation 11.30 9.79 50 178189 40896 79525253
Hot flush 11.27 9.79 74 178165 54803 79511346
Contusion 11.23 9.79 250 177989 148526 79417623
Peptic ulcer 11.21 9.79 35 178204 6188 79559961
Blood loss anaemia 11.19 9.79 66 178173 15432 79550717
Pericardial effusion 11.18 9.79 155 178084 46082 79520067
Abortion incomplete complicated 11.18 9.79 3 178236 9 79566140
Central nervous system injury 11.17 9.79 6 178233 157 79565992
Hydronephrosis 11.14 9.79 72 178167 17382 79548767
Vascular device infection 11.10 9.79 49 178190 10227 79555922
Multiple-drug resistance 11.04 9.79 3 178236 8805 79557344
Mitral valve disease 11.03 9.79 23 178216 3174 79562975
Haemodialysis 11.02 9.79 74 178165 18094 79548055
Potassium wasting nephropathy 10.94 9.79 6 178233 164 79565985
Hallucination, visual 10.94 9.79 37 178202 32692 79533457
Post transplant lymphoproliferative disorder 10.91 9.79 6 178233 11458 79554691
Influenza like illness 10.88 9.79 105 178134 71602 79494547
Blood sodium decreased 10.87 9.79 118 178121 33137 79533012
Tardive dyskinesia 10.86 9.79 5 178234 10566 79555583
Enterococcus test positive 10.86 9.79 18 178221 2086 79564063
Exostosis 10.85 9.79 13 178226 16845 79549304
Decubitus ulcer 10.81 9.79 66 178173 15621 79550528
Substance abuse 10.78 9.79 5 178234 10521 79555628
Bilirubin conjugated increased 10.77 9.79 32 178207 5507 79560642
Protein urine present 10.76 9.79 48 178191 10064 79556085
Drug use disorder 10.75 9.79 3 178236 8648 79557501
Coeliac disease 10.72 9.79 6 178233 11345 79554804
Splenic injury 10.71 9.79 7 178232 265 79565884
Right ventricular dilatation 10.65 9.79 17 178222 1909 79564240
Poor venous access 10.64 9.79 15 178224 18134 79548015
Nausea 10.64 9.79 2355 175884 954841 78611308
Blood cholesterol decreased 10.63 9.79 16 178223 1709 79564440
Epilepsy 10.62 9.79 51 178188 40809 79525340
Psychotic disorder 10.57 9.79 52 178187 41350 79524799
Thrombotic microangiopathy 10.56 9.79 18 178221 20151 79545998
Chronic kidney disease 10.51 9.79 207 178032 65947 79500202
Rhinorrhoea 10.47 9.79 114 178125 75960 79490189
Blood aldosterone abnormal 10.42 9.79 4 178235 46 79566103
Blood gases abnormal 10.38 9.79 13 178226 1167 79564982
Arteriovenous malformation 10.38 9.79 16 178223 1745 79564404
Chronic kidney disease-mineral and bone disorder 10.28 9.79 9 178230 532 79565617
Temperature intolerance 10.27 9.79 46 178193 9659 79556490
Right atrial pressure increased 10.26 9.79 7 178232 285 79565864
Progressive multifocal leukoencephalopathy 10.23 9.79 19 178220 20581 79545568
Bone erosion 10.22 9.79 15 178224 17832 79548317
Encapsulating peritoneal sclerosis 10.21 9.79 11 178228 840 79565309
Cardiac disorder 10.20 9.79 205 178034 65552 79500597
Vitamin B1 deficiency 10.14 9.79 10 178229 688 79565461
Photophobia 10.13 9.79 19 178220 20509 79545640
Cataract operation 10.12 9.79 30 178209 5155 79560994
Upper gastrointestinal haemorrhage 10.12 9.79 139 178100 41241 79524908
Catheterisation cardiac 10.12 9.79 32 178207 5696 79560453
Oxalosis 10.10 9.79 5 178234 110 79566039
Metastases to bone 10.07 9.79 25 178214 24402 79541747
Retroperitoneal haemorrhage 10.07 9.79 31 178208 5439 79560710
Visual acuity reduced 10.06 9.79 33 178206 29436 79536713
HLA-B*27 positive 10.06 9.79 5 178234 111 79566038
Carbon dioxide increased 10.04 9.79 18 178221 2222 79563927
Occult blood positive 9.99 9.79 36 178203 6847 79559302
Thyroxine decreased 9.98 9.79 11 178228 862 79565287
Pharyngitis 9.95 9.79 22 178217 22353 79543796
Bronchial disorder 9.90 9.79 19 178220 2470 79563679
Sinus tachycardia 9.87 9.79 126 178113 36782 79529367
Deposit eye 9.85 9.79 4 178235 54 79566095
Hyperinsulinaemia 9.84 9.79 6 178233 201 79565948
Therapy non-responder 9.84 9.79 146 178093 92159 79473990
Mania 9.83 9.79 16 178223 18244 79547905
Lung disorder 9.81 9.79 124 178115 80433 79485716

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperglycaemia 34.07 26.81 13 305 90 89384
Product preparation error 28.10 26.81 11 307 82 89392

Pharmacologic Action:

SourceCodeDescription
ATC B05CX01 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
IRRIGATING SOLUTIONS
Other irrigating solutions
ATC C05BB56 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
ANTIVARICOSE THERAPY
Sclerosing agents for local injection
ATC V04CA02 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Tests for diabetes
ATC V06DC01 VARIOUS
GENERAL NUTRIENTS
OTHER NUTRIENTS
Carbohydrates
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
MeSH PA D005421 Flavoring Agents
MeSH PA D005503 Food Additives
MeSH PA D013549 Sweetening Agents
CHEBI has role CHEBI:78675 fundamental metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypoglycemia indication 302866003 DOID:9993




🐶 Veterinary Drug Use

SpeciesUseRelation
Cattle Dehydration associated with diarrhea Indication
Cattle Early treatment of scouring Indication
Cattle Followup treatment following intravenous fluid therapy Indication

🐶 Veterinary products

ProductApplicantIngredients
Re-Sorb, Vytrate Zoetis Inc. 6

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.87 acidic
pKa2 13.08 acidic
pKa3 13.91 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019541 VUID
N0000147647 NUI
D00009 KEGG_DRUG
77938-63-7 SECONDARY_CAS_RN
50-99-7 SECONDARY_CAS_RN
1299920 RXNORM
4017760 VANDF
4019541 VANDF
C0017725 UMLSCUI
CHEBI:4167 CHEBI
BGC PDB_CHEM_ID
CHEMBL1222250 ChEMBL_ID
D005947 MESH_DESCRIPTOR_UI
DB09341 DRUGBANK_ID
4536 IUPHAR_LIGAND_ID
5793 PUBCHEM_CID
DB01914 DRUGBANK_ID
11133 MMSL
4567 MMSL
4787 MMSL
71873 MMSL
71874 MMSL
9763 MMSL
d00595 MMSL
000915 NDDF
002597 NDDF
111138002 SNOMEDCT_US
67079006 SNOMEDCT_US
725859007 SNOMEDCT_US
768547002 SNOMEDCT_US
LX22YL083G UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0264-1290 INJECTION, SOLUTION 70 g INTRAVENOUS UNAPPROVED DRUG OTHER 24 sections
Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0264-1510 INJECTION, SOLUTION 50 mg INTRAVENOUS NDA 24 sections
Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0264-1510 INJECTION, SOLUTION 50 mg INTRAVENOUS NDA 24 sections
MYOCARD-DX HUMAN PRESCRIPTION DRUG LABEL 2 0264-1840 INJECTION 5 g INTRAVENOUS EXPORT ONLY 20 sections
MYOCARD-DX HUMAN PRESCRIPTION DRUG LABEL 2 0264-1840 INJECTION 5 g INTRAVENOUS EXPORT ONLY 20 sections
MYOCARD-DX HUMAN PRESCRIPTION DRUG LABEL 2 0264-1880 INJECTION 5 g INTRAVENOUS EXPORT ONLY 20 sections
MYOCARD-DX HUMAN PRESCRIPTION DRUG LABEL 2 0264-1880 INJECTION 5 g INTRAVENOUS EXPORT ONLY 20 sections
Isolyte P in Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0264-7730 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 23 sections
Isolyte P in Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0264-7730 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 23 sections
Dextrose in Lactated Ringers HUMAN PRESCRIPTION DRUG LABEL 5 0264-7751 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 22 sections
Theophylline in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9554 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 27 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9567 INJECTION 5 g INTRAVENOUS NDA 19 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9567 INJECTION 5 g INTRAVENOUS NDA 19 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9577 INJECTION 5 g INTRAVENOUS NDA 19 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9577 INJECTION 5 g INTRAVENOUS NDA 19 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9587 INJECTION 5 g INTRAVENOUS NDA 19 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9587 INJECTION 5 g INTRAVENOUS NDA 19 sections
Lidocaine Hydrochloride and Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9594 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 23 sections
Lidocaine Hydrochloride and Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9594 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 23 sections
Lidocaine Hydrochloride and Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9598 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 23 sections
Lidocaine Hydrochloride and Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9598 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 23 sections
DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0017 INJECTION, SOLUTION 50 g INTRAVENOUS NDA 21 sections
DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0017 INJECTION, SOLUTION 50 g INTRAVENOUS NDA 21 sections
DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0023 INJECTION, SOLUTION 100 g INTRAVENOUS NDA 21 sections
DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0023 INJECTION, SOLUTION 100 g INTRAVENOUS NDA 21 sections
DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0062 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 21 sections
DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0062 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 21 sections
DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0066 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 21 sections
DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0066 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 21 sections
DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0070 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 21 sections