glucose Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
845 492-61-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dextrose
  • D-Glucose
  • (+)-Glucose
  • glucose
  • dextrose monohydrate
  • anhydrous dextrose
  • glucose monohydrate
  • anhydrous glucose
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
  • Molecular weight: 180.16
  • Formula: C6H12O6
  • CLOGP: -2.90
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 5
  • TPSA: 110.38
  • ALOGS: 0.16
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Jan. 17, 1946 FDA B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Peritonitis bacterial 2226.68 9.79 856 134403 8649 53205158
Death 1904.43 9.79 3308 131951 353924 52859883
Peritonitis 1623.20 9.79 882 134377 20805 53193002
Fluid overload 912.18 9.79 671 134588 27160 53186647
Peritoneal dialysis complication 845.85 9.79 305 134954 2528 53211279
Drug ineffective 522.52 9.79 794 134465 816451 52397356
Rheumatoid arthritis 489.55 9.79 101 135158 314430 52899377
Sepsis 280.91 9.79 913 134346 145516 53068291
Bloody peritoneal effluent 278.82 9.79 86 135173 409 53213398
Cardiac failure congestive 262.10 9.79 665 134594 92092 53121715
Hypokalaemia 245.18 9.79 665 134594 95852 53117955
Myelosuppression 244.78 9.79 226 135033 12602 53201205
Ultrafiltration failure 230.95 9.79 80 135179 581 53213226
Fungal peritonitis 227.14 9.79 86 135173 828 53212979
Joint swelling 222.86 9.79 162 135097 234476 52979331
Contraindicated product administered 207.69 9.79 45 135214 135584 53078223
Hypotension 195.63 9.79 1206 134053 252870 52960937
Hand deformity 195.35 9.79 4 135255 84845 53128962
Dehydration 195.17 9.79 895 134364 167515 53046292
Alopecia 185.14 9.79 193 135066 234390 52979417
Systemic lupus erythematosus 177.60 9.79 49 135210 125365 53088442
Arthropathy 168.15 9.79 74 135185 141379 53072428
Arthralgia 167.74 9.79 564 134695 439219 52774588
Pneumonia 167.13 9.79 1670 133589 405499 52808308
Glossodynia 164.69 9.79 28 135231 100263 53113544
Blood potassium decreased 153.70 9.79 326 134933 40134 53173673
Cardiac arrest 152.29 9.79 553 134706 93114 53120693
Off label use 148.88 9.79 654 134605 471558 52742249
Therapeutic product effect decreased 141.22 9.79 71 135188 125584 53088223
Pain 134.76 9.79 907 134352 587491 52626316
Acute myocardial infarction 127.64 9.79 269 134990 32966 53180841
Drug intolerance 123.30 9.79 207 135052 205286 53008521
Catheter site infection 121.46 9.79 101 135158 4891 53208916
Abdominal distension 120.43 9.79 460 134799 79330 53134477
Product use issue 117.94 9.79 108 135151 139476 53074331
Hyperkalaemia 115.52 9.79 351 134908 53905 53159902
Colitis microscopic 110.86 9.79 112 135147 6982 53206825
Infusion related reaction 110.29 9.79 140 135119 155817 53057990
Fluid retention 107.56 9.79 343 134916 54058 53159749
Hypervolaemia 105.91 9.79 67 135192 2106 53211701
Diabetic foot 104.37 9.79 61 135198 1657 53212150
Respiratory failure 103.12 9.79 516 134743 99996 53113811
Rash 102.35 9.79 687 134572 445504 52768303
Pericarditis 101.37 9.79 20 135239 64386 53149421
Drug hypersensitivity 101.00 9.79 340 134919 264902 52948905
Cardio-respiratory arrest 100.66 9.79 353 134906 58405 53155402
Musculoskeletal stiffness 100.06 9.79 99 135160 123269 53090538
Peritoneal cloudy effluent 100.01 9.79 35 135224 263 53213544
Drug abuse 99.73 9.79 22 135237 65504 53148303
Lower respiratory tract infection 98.38 9.79 54 135205 90927 53122880
Pneumonia aspiration 97.90 9.79 247 135012 34054 53179753
Bone marrow failure 96.77 9.79 227 135032 29888 53183919
Wound 92.43 9.79 59 135200 91498 53122309
Cardiovascular disorder 90.20 9.79 133 135126 12280 53201527
Pulmonary oedema 89.66 9.79 320 134939 53403 53160404
Procedural pain 87.82 9.79 144 135115 14573 53199234
Pleural effusion 87.53 9.79 450 134809 88129 53125678
Myocardial infarction 87.48 9.79 489 134770 98865 53114942
Cerebrovascular accident 86.94 9.79 509 134750 104665 53109142
Disease complication 85.89 9.79 69 135190 3181 53210626
Hypoxia 84.81 9.79 322 134937 55358 53158449
Therapeutic product effect incomplete 82.39 9.79 67 135192 91717 53122090
Malnutrition 81.41 9.79 140 135119 14731 53199076
Gastrointestinal haemorrhage 81.39 9.79 411 134848 79919 53133888
Maternal exposure during pregnancy 79.96 9.79 172 135087 155467 53058340
Oedema peripheral 79.94 9.79 721 134538 170066 53043741
Multimorbidity 78.05 9.79 38 135221 705 53213102
Pulmonary hypertension 74.58 9.79 236 135023 37034 53176773
Hypersensitivity 73.52 9.79 280 134979 210385 53003422
Headache 72.67 9.79 943 134316 535878 52677929
Atrial fibrillation 72.32 9.79 508 134751 111144 53102663
Psoriasis 71.63 9.79 69 135190 87020 53126787
Cardiac failure 71.28 9.79 416 134843 85428 53128379
Helicobacter infection 70.96 9.79 8 135251 39061 53174746
Hypoglycaemia 69.98 9.79 316 134943 58697 53155110
Acute respiratory failure 68.19 9.79 204 135055 31054 53182753
Cardiac disorder 67.76 9.79 267 134992 46699 53167108
Treatment failure 66.69 9.79 141 135118 128262 53085545
Injection site pain 66.32 9.79 116 135143 113275 53100532
Nasopharyngitis 66.18 9.79 257 135002 192038 53021769
Right ventricular failure 65.44 9.79 137 135122 16706 53197101
Completed suicide 62.78 9.79 163 135096 138038 53075769
Abortion spontaneous 62.73 9.79 20 135239 46615 53167192
Asthenia 62.16 9.79 1219 134040 342371 52871436
Inadequate aseptic technique in use of product 61.85 9.79 20 135239 114 53213693
Muscle injury 59.74 9.79 4 135255 29762 53184045
Fatigue 59.39 9.79 1406 133853 729100 52484707
Psoriatic arthropathy 59.16 9.79 24 135235 48166 53165641
Electrolyte imbalance 58.13 9.79 140 135119 18744 53195063
Glaucoma 57.74 9.79 131 135128 16872 53196935
Mental status changes 57.11 9.79 225 135034 39346 53174461
Toxicity to various agents 57.01 9.79 325 134934 219273 52994534
Hepatic enzyme increased 56.43 9.79 150 135109 126045 53087762
Folliculitis 56.33 9.79 7 135252 31702 53182105
Suicidal ideation 55.77 9.79 43 135216 60468 53153339
Abdominal pain 55.40 9.79 934 134325 254969 52958838
Fluid imbalance 53.64 9.79 25 135234 419 53213388
Synovitis 52.32 9.79 123 135136 107770 53106037
Injection site reaction 51.59 9.79 33 135226 51133 53162674
Abdominal discomfort 51.21 9.79 339 134920 220723 52993084
Pleuroperitoneal communication 49.94 9.79 15 135244 64 53213743
Injection site erythema 49.88 9.79 74 135185 77175 53136632
Asthma 49.88 9.79 128 135131 108844 53104963
Swelling 49.50 9.79 283 134976 190822 53022985
Acute kidney injury 48.00 9.79 907 134352 252961 52960846
Irritable bowel syndrome 47 9.79 26 135233 43606 53170201
Diverticulitis 46.46 9.79 197 135062 35604 53178203
Device related infection 46.24 9.79 145 135114 22641 53191166
Oedema 46.22 9.79 335 134924 74011 53139796
Sinusitis 46.18 9.79 245 135014 168319 53045488
Loss of personal independence in daily activities 45.94 9.79 66 135193 69749 53144058
Non-cardiogenic pulmonary oedema 45.70 9.79 25 135234 596 53213211
Umbilical hernia 45.18 9.79 45 135214 2757 53211050
Cytokine release syndrome 45.11 9.79 77 135182 8052 53205755
Discomfort 44.58 9.79 111 135148 95361 53118446
Diabetes insipidus 44.36 9.79 43 135216 2548 53211259
Injection site bruising 44.21 9.79 20 135239 37626 53176181
Intentional self-injury 43.90 9.79 6 135253 25278 53188529
Septic shock 43.76 9.79 289 134970 61940 53151867
Anaemia 43.52 9.79 962 134297 275756 52938051
Renal ischaemia 43.43 9.79 24 135235 584 53213223
Noninfectious peritonitis 43.01 9.79 18 135241 230 53213577
Impaired healing 42.94 9.79 60 135199 64145 53149662
Sopor 41.82 9.79 3 135256 21081 53192726
Hernia 41.67 9.79 85 135174 10175 53203632
Injection site swelling 40.95 9.79 29 135230 42599 53171208
Diabetic complication 40.25 9.79 27 135232 939 53212868
Febrile neutropenia 39.75 9.79 424 134835 104512 53109295
Pregnancy 39.67 9.79 15 135244 31426 53182381
Hypophagia 38.83 9.79 169 135090 30893 53182914
Product use in unapproved indication 38.64 9.79 150 135109 112139 53101668
Blood urea increased 38.54 9.79 150 135109 26081 53187726
Dyspnoea 38.28 9.79 1834 133425 584398 52629409
Peritoneal effluent abnormal 38.09 9.79 12 135247 62 53213745
Arthritis 38.08 9.79 105 135154 87193 53126614
Ill-defined disorder 37.46 9.79 42 135217 49402 53164405
PO2 increased 37.28 9.79 25 135234 869 53212938
Hypernatraemia 37.16 9.79 65 135194 6932 53206875
Haemoglobin decreased 36.49 9.79 519 134740 136788 53077019
International normalised ratio increased 35.53 9.79 225 135034 47536 53166271
Renal failure 35.28 9.79 457 134802 117995 53095812
Gangrene 35.06 9.79 52 135207 4825 53208982
Pulmonary arterial hypertension 35.00 9.79 149 135110 26973 53186834
C-reactive protein abnormal 34.96 9.79 11 135248 25859 53187948
Treatment noncompliance 34.84 9.79 171 135088 32864 53180943
Injection site pruritus 34.13 9.79 33 135226 41556 53172251
Intentional product use issue 34.06 9.79 84 135175 72410 53141397
Azotaemia 33.72 9.79 49 135210 4464 53209343
Urticaria 33.69 9.79 204 135055 135681 53078126
Failure to thrive 33.36 9.79 62 135197 6930 53206877
Catheter site extravasation 32.05 9.79 16 135243 314 53213493
Blood pressure decreased 31.92 9.79 267 134992 61602 53152205
Blood bilirubin increased 30.85 9.79 175 135084 35555 53178252
Gastrooesophageal reflux disease 30.83 9.79 333 134926 82330 53131477
Heparin-induced thrombocytopenia 30.57 9.79 47 135212 4502 53209305
Blood magnesium decreased 30.55 9.79 82 135177 11732 53202075
PCO2 increased 29.93 9.79 25 135234 1218 53212589
Pneumoperitoneum 29.72 9.79 28 135231 1601 53212206
Condition aggravated 29.53 9.79 553 134706 296581 52917226
Hip arthroplasty 29.44 9.79 17 135242 27845 53185962
Sleep disorder 29.43 9.79 66 135193 58804 53155003
Decreased appetite 29.35 9.79 733 134526 214241 52999566
Inappropriate schedule of product administration 29.11 9.79 95 135164 74783 53139024
Cor pulmonale 28.53 9.79 30 135229 1960 53211847
Coma 28.43 9.79 260 134999 61523 53152284
Therapeutic response decreased 28.40 9.79 48 135211 47521 53166286
Cardiogenic shock 28.19 9.79 103 135156 17379 53196428
Brain natriuretic peptide increased 27.79 9.79 47 135212 4878 53208929
Device occlusion 27.42 9.79 56 135203 6709 53207098
Atrial flutter 27.29 9.79 69 135190 9522 53204285
Knee arthroplasty 27.12 9.79 27 135232 33542 53180265
Chronic obstructive pulmonary disease 27.09 9.79 255 135004 60818 53152989
Paraesthesia 26.82 9.79 201 135058 127314 53086493
Cardiac dysfunction 26.78 9.79 28 135231 1817 53211990
Blood albumin decreased 26.31 9.79 89 135170 14453 53199354
Multiple sclerosis relapse 26.10 9.79 46 135213 44807 53169000
Calcium deficiency 26.03 9.79 21 135238 974 53212833
Red blood cell sedimentation rate increased 25.77 9.79 20 135239 28037 53185770
Drug interaction 25.73 9.79 396 134863 218933 52994874
Vomiting 25.69 9.79 1522 133737 495617 52718190
Blood cholesterol increased 25.20 9.79 61 135198 52928 53160879
Deep vein thrombosis 25.14 9.79 321 134938 82592 53131215
Blood glucose decreased 25.09 9.79 109 135150 19907 53193900
Abdominal hernia 25.08 9.79 45 135214 4895 53208912
Inflammation 24.71 9.79 69 135190 57067 53156740
Acute left ventricular failure 23.95 9.79 19 135240 860 53212947
Thrombocytopenia 23.93 9.79 489 134770 138238 53075569
Exposure during pregnancy 23.86 9.79 202 135057 124658 53089149
Encephalopathy 23.53 9.79 167 135092 36641 53177166
Encapsulating peritoneal sclerosis 23.41 9.79 14 135245 397 53213410
Wrong product administered 23.26 9.79 49 135210 5999 53207808
Blood potassium increased 23.01 9.79 98 135161 17743 53196064
Bronchitis 22.92 9.79 405 134854 111494 53102313
Plasma cell myeloma 22.81 9.79 203 135056 47671 53166136
Drug reaction with eosinophilia and systemic symptoms 22.58 9.79 30 135229 32770 53181037
Migraine 22.49 9.79 116 135143 80301 53133506
Pruritus 22.22 9.79 571 134688 293261 52920546
Wrong technique in product usage process 22.08 9.79 78 135181 59954 53153853
Blood bicarbonate decreased 21.90 9.79 32 135227 2930 53210877
White blood cell count decreased 21.87 9.79 440 134819 124035 53089772
Hypovolaemia 21.85 9.79 67 135192 10335 53203472
Hyperglycaemia 21.76 9.79 175 135084 39909 53173898
Herpes zoster 21.72 9.79 105 135154 73914 53139893
Disability 21.62 9.79 3 135256 12495 53201312
Serotonin syndrome 21.61 9.79 21 135238 26385 53187422
Pulse absent 21.60 9.79 44 135215 5262 53208545
Tonsillar haemorrhage 21.45 9.79 11 135248 229 53213578
Bacteraemia 21.30 9.79 87 135172 15462 53198345
Multiple organ dysfunction syndrome 21.08 9.79 225 135034 55452 53158355
Extremity necrosis 21.08 9.79 24 135235 1715 53212092
Urine chloride decreased 21.04 9.79 8 135251 78 53213729
Haemorrhage 20.88 9.79 232 135027 57755 53156052
Cardiomegaly 20.85 9.79 95 135164 17705 53196102
Urinary tract infection 20.64 9.79 773 134486 239130 52974677
Peritoneal effluent leukocyte count increased 20.28 9.79 6 135253 24 53213783
Product selection error 20.27 9.79 8 135251 87 53213720
Respiratory distress 20.20 9.79 151 135108 33676 53180131
Muscle spasticity 20.14 9.79 10 135249 17828 53195979
Metabolic alkalosis 20.02 9.79 31 135228 2988 53210819
Posterior reversible encephalopathy syndrome 19.91 9.79 8 135251 16152 53197655
Transfusion 19.88 9.79 78 135181 13609 53200198
Vertigo 19.88 9.79 74 135185 56007 53157800
Insomnia 19.87 9.79 344 134915 186728 53027079
Small intestinal obstruction 19.70 9.79 91 135168 17056 53196751
Joint stiffness 19.55 9.79 29 135230 30254 53183553
Prothrombin time prolonged 19.46 9.79 62 135197 9760 53204047
Staphylococcus test positive 19.31 9.79 35 135224 3838 53209969
Electrocardiogram T wave peaked 19.13 9.79 10 135249 217 53213590
Bacterial translocation 19.13 9.79 10 135249 217 53213590
Hepatocellular injury 19.08 9.79 29 135230 29957 53183850
Gastrointestinal disorder 18.86 9.79 142 135117 89862 53123945
Blood pH decreased 18.85 9.79 28 135231 2602 53211205
Unresponsive to stimuli 18.72 9.79 147 135112 33279 53180528
Cognitive disorder 18.68 9.79 55 135204 44723 53169084
Foot deformity 18.68 9.79 12 135247 18556 53195251
Metabolic encephalopathy 18.63 9.79 44 135215 5817 53207990
Cardiac failure acute 18.57 9.79 58 135201 9034 53204773
Diarrhoea 18.54 9.79 1833 133426 623713 52590094
Hypomagnesaemia 18.52 9.79 117 135142 24694 53189113
Catheter management 18.51 9.79 29 135230 2823 53210984
Tendonitis 18.51 9.79 10 135249 16996 53196811
Osteonecrosis of jaw 18.49 9.79 40 135219 36106 53177701
Osteoarthritis 18.43 9.79 104 135155 70382 53143425
Hypoalbuminaemia 18.11 9.79 65 135194 10871 53202936
Overdose 18.11 9.79 180 135079 107556 53106251
Gait disturbance 17.87 9.79 289 134970 158553 53055254
Acne 17.86 9.79 17 135242 21569 53192238
Grip strength decreased 17.76 9.79 4 135255 11745 53202062
Oxygen consumption increased 17.63 9.79 33 135226 3708 53210099
Procedural complication 17.52 9.79 40 135219 5172 53208635
Injection site warmth 17.40 9.79 7 135252 14121 53199686
Peritoneal disorder 17.35 9.79 13 135246 540 53213267
Blood glucose increased 17.29 9.79 284 134975 77077 53136730
Generalised oedema 17.25 9.79 80 135179 15019 53198788
Full blood count decreased 17.13 9.79 112 135147 23917 53189890
Blister 17.10 9.79 123 135136 78630 53135177
Oxygen saturation abnormal 17.07 9.79 28 135231 2834 53210973
Abdominal pain upper 16.95 9.79 308 134951 165983 53047824
Hepatitis 16.93 9.79 38 135221 33856 53179951
Device related sepsis 16.93 9.79 32 135227 3623 53210184
Granulocytopenia 16.87 9.79 41 135218 5519 53208288
Mental status changes postoperative 16.78 9.79 9 135250 206 53213601
Device difficult to use 16.76 9.79 3 135256 10356 53203451
Mobility decreased 16.62 9.79 119 135140 76152 53137655
Blood calcium decreased 16.46 9.79 96 135163 19698 53194109
Injection site rash 16.29 9.79 11 135248 16568 53197239
Corneal oedema 16.26 9.79 22 135237 1875 53211932
Blood potassium abnormal 16.20 9.79 25 135234 2402 53211405
Pain in extremity 16.09 9.79 576 134683 284474 52929333
Hydrothorax 15.84 9.79 14 135245 737 53213070
Extravasation 15.84 9.79 24 135235 2270 53211537
Tenosynovitis 15.82 9.79 3 135256 9936 53203871
Oropharyngeal pain 15.74 9.79 131 135128 81137 53132670
Fibromyalgia 15.72 9.79 58 135201 44017 53169790
Intentional product misuse 15.72 9.79 68 135191 49324 53164483
Chest pain 15.68 9.79 610 134649 189575 53024232
Suicide attempt 15.66 9.79 85 135174 58083 53155724
Haematocrit decreased 15.63 9.79 154 135105 37177 53176630
Urine sodium decreased 15.62 9.79 8 135251 166 53213641
Arrhythmia 15.53 9.79 152 135107 36627 53177180
Decubitus ulcer 15.41 9.79 60 135199 10433 53203374
Product storage error 15.38 9.79 7 135252 13123 53200684
Ventricular tachycardia 15.33 9.79 87 135172 17675 53196132
Ascites 15.24 9.79 161 135098 39574 53174233
Marasmus 15.19 9.79 12 135247 540 53213267
Supraventricular tachycardia 14.99 9.79 74 135185 14251 53199556
Acinetobacter sepsis 14.94 9.79 3 135256 0 53213807
Vascular device infection 14.94 9.79 34 135225 4387 53209420
Clostridium difficile infection 14.72 9.79 121 135138 27772 53186035
Blood alkaline phosphatase increased 14.67 9.79 165 135094 41197 53172610
Critical illness 14.65 9.79 8 135251 190 53213617
Pancytopenia 14.53 9.79 317 134942 90611 53123196
Pharyngitis 14.51 9.79 16 135243 18964 53194843
Oxalosis 14.47 9.79 5 135254 36 53213771
Activated partial thromboplastin time prolonged 14.39 9.79 45 135214 7014 53206793
Impaired work ability 14.32 9.79 9 135250 14081 53199726
Atelectasis 14.28 9.79 93 135166 19833 53193974
Dry eye 14.27 9.79 41 135218 33603 53180204
Platelet count decreased 14.26 9.79 367 134892 107732 53106075
Accidental exposure to product 14.03 9.79 24 135235 23650 53190157
Depression 14.01 9.79 355 134904 182697 53031110
Interstitial lung disease 14.00 9.79 89 135170 58533 53155274
Colitis 13.95 9.79 164 135095 41388 53172419
Tachypnoea 13.91 9.79 78 135181 15776 53198031
Catheter site haemorrhage 13.84 9.79 26 135233 2929 53210878
Hyponatraemia 13.83 9.79 367 134892 108240 53105567
Skin dystrophy 13.80 9.79 5 135254 42 53213765
Hot flush 13.77 9.79 67 135192 47093 53166714
Stomatitis 13.72 9.79 171 135088 97987 53115820
Product substitution issue 13.71 9.79 12 135247 15854 53197953
Shock 13.65 9.79 103 135156 23036 53190771
Posthaemorrhagic hydrocephalus 13.52 9.79 4 135255 16 53213791
Escherichia peritonitis 13.52 9.79 4 135255 16 53213791
Ventricular fibrillation 13.49 9.79 63 135196 11862 53201945
Cholelithiasis 13.45 9.79 161 135098 40803 53173004
Abdominal incarcerated hernia 13.33 9.79 4 135255 17 53213790
Nutritional condition abnormal 13.32 9.79 13 135246 777 53213030
Catheter site abscess 13.31 9.79 5 135254 47 53213760
Nosocomial infection 13.23 9.79 19 135240 1712 53212095
Coeliac disease 13.15 9.79 3 135256 8732 53205075
Poisoning deliberate 13.10 9.79 3 135256 8710 53205097
Product compounding quality issue 13.07 9.79 6 135253 97 53213710
Drug resistance 13 9.79 19 135240 19943 53193864
Product residue present 12.99 9.79 31 135228 4125 53209682
Oral herpes 12.99 9.79 21 135238 21158 53192649
Postoperative adhesion 12.98 9.79 8 135251 240 53213567
Movement disorder 12.95 9.79 17 135242 18664 53195143
Blood chloride decreased 12.92 9.79 37 135222 5494 53208313
Confusion postoperative 12.86 9.79 8 135251 244 53213563
Blood creatinine increased 12.83 9.79 287 134972 82375 53131432
Aspartate aminotransferase increased 12.81 9.79 291 134968 83738 53130069
Akathisia 12.79 9.79 3 135256 8568 53205239
Post procedural complication 12.69 9.79 79 135180 16587 53197220
Foetal death 12.57 9.79 52 135207 9295 53204512
Poisoning 12.56 9.79 10 135249 13840 53199967
Psychomotor hyperactivity 12.43 9.79 5 135254 10091 53203716
Toxic epidermal necrolysis 12.34 9.79 102 135157 23448 53190359
Depressed mood 12.31 9.79 50 135209 36914 53176893
Alkalosis 12.27 9.79 9 135250 362 53213445
Sudden death 12.23 9.79 55 135204 10193 53203614
Cyst 12.12 9.79 9 135250 12902 53200905
Torsade de pointes 12.09 9.79 65 135194 12940 53200867
Ileus 12.09 9.79 72 135187 14883 53198924
Thrombosis 12.07 9.79 219 135040 60574 53153233
Obstructive airways disorder 11.94 9.79 16 135243 17413 53196394
Nodule 11.94 9.79 16 135243 17413 53196394
Chronic kidney disease 11.93 9.79 165 135094 43205 53170602
Calciphylaxis 11.89 9.79 24 135235 2851 53210956
Cellulitis 11.85 9.79 264 134995 75725 53138082
Hypoaesthesia 11.83 9.79 252 135007 132743 53081064
Hyperoxaluria 11.78 9.79 6 135253 123 53213684
Haemodynamic instability 11.70 9.79 48 135211 8546 53205261
Upper gastrointestinal haemorrhage 11.68 9.79 80 135179 17350 53196457
Thyroid disorder 11.63 9.79 66 135193 13407 53200400
Adverse event 11.61 9.79 59 135200 41002 53172805
Cardiovascular insufficiency 11.59 9.79 16 135243 1390 53212417
Urosepsis 11.58 9.79 77 135182 16533 53197274
Incision site pain 11.52 9.79 14 135245 1072 53212735
Pseudomonal bacteraemia 11.51 9.79 16 135243 1399 53212408
Blood pressure diastolic abnormal 11.32 9.79 4 135255 8741 53205066
Gastrointestinal stoma output decreased 11.32 9.79 4 135255 31 53213776
Incarcerated hernia 11.32 9.79 6 135253 134 53213673
Infantile apnoea 11.30 9.79 13 135246 939 53212868
Sedation 11.29 9.79 38 135221 29637 53184170
Schizophrenia 11.25 9.79 6 135253 10273 53203534
Coagulopathy 11.24 9.79 87 135172 19611 53194196
Tissue injury 11.21 9.79 4 135255 32 53213775
Pericardial effusion 11.16 9.79 112 135147 27166 53186641
Panniculitis 11.15 9.79 3 135256 7811 53205996
Cardiac procedure complication 11.12 9.79 7 135252 218 53213589
Type 2 diabetes mellitus 11.08 9.79 42 135217 31628 53182179
Hip fracture 11.07 9.79 115 135144 28142 53185665
Labelled drug-drug interaction medication error 11.02 9.79 7 135252 10892 53202915
Cytotoxic oedema 11.01 9.79 6 135253 142 53213665
Myalgia 11 9.79 256 135003 133235 53080572
Abortion induced 10.89 9.79 7 135252 10819 53202988
Leukocytosis 10.83 9.79 103 135156 24631 53189176
Device leakage 10.81 9.79 37 135222 6043 53207764
Gallbladder necrosis 10.80 9.79 3 135256 9 53213798
Sinoatrial block 10.80 9.79 12 135247 835 53212972
Urine output decreased 10.75 9.79 58 135201 11565 53202242
Disseminated intravascular coagulation 10.65 9.79 86 135173 19633 53194174
Central nervous system injury 10.64 9.79 6 135253 152 53213655
Ear pain 10.61 9.79 39 135220 29634 53184173
Corynebacterium test positive 10.61 9.79 4 135255 38 53213769
Serratia sepsis 10.61 9.79 5 135254 86 53213721
Stress 10.61 9.79 93 135166 56991 53156816
Night sweats 10.58 9.79 49 135210 34898 53178909
Product quality issue 10.58 9.79 53 135206 36970 53176837
Clostridium difficile colitis 10.57 9.79 86 135173 19679 53194128
Vascular access malfunction 10.52 9.79 4 135255 39 53213768
Product preparation error 10.52 9.79 30 135229 4445 53209362
Retinal ischaemia 10.50 9.79 8 135251 341 53213466
Acidosis hyperchloraemic 10.44 9.79 8 135251 344 53213463
Basal cell carcinoma 10.40 9.79 28 135231 23441 53190366
Staphylococcal infection 10.34 9.79 146 135113 38402 53175405
Oncologic complication 10.33 9.79 6 135253 161 53213646
Hyperdynamic left ventricle 10.30 9.79 6 135253 162 53213645
Hyperchloraemia 10.21 9.79 11 135248 739 53213068
Diabetic vascular disorder 10.17 9.79 4 135255 43 53213764
Pseudomonas peritonitis 10.14 9.79 3 135256 12 53213795
Influenza like illness 10.09 9.79 102 135157 60757 53153050
Blood aldosterone abnormal 10.01 9.79 4 135255 45 53213762
Extrapyramidal disorder 9.99 9.79 10 135249 12392 53201415
Chronic respiratory failure 9.95 9.79 17 135242 1779 53212028
Fibrin 9.93 9.79 4 135255 46 53213761
Overgrowth bacterial 9.93 9.79 5 135254 100 53213707
Joint range of motion decreased 9.93 9.79 19 135240 17937 53195870
Intestinal obstruction 9.89 9.79 114 135145 28627 53185180
Blood calcium abnormal 9.85 9.79 13 135246 1082 53212725
Immune effector cell-associated neurotoxicity syndrome 9.80 9.79 13 135246 1087 53212720
Neutrophil count decreased 9.80 9.79 177 135082 48921 53164886

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Peritonitis bacterial 2932.78 10.39 1186 98258 11310 32402772
Peritonitis 2098.00 10.39 1124 98320 21206 32392876
Death 1838.82 10.39 3764 95680 378753 32035329
Peritoneal dialysis complication 1235.60 10.39 472 98972 3796 32410286
Fluid overload 1089.05 10.39 703 98741 18918 32395164
Abdominal distension 356.01 10.39 595 98849 50700 32363382
Ultrafiltration failure 308.54 10.39 108 99336 655 32413427
Fungal peritonitis 304.75 10.39 127 99317 1309 32412773
Drug ineffective 264.67 10.39 482 98962 382995 32031087
Bloody peritoneal effluent 246.87 10.39 85 99359 487 32413595
Sepsis 245.15 10.39 1048 98396 157786 32256296
Catheter site infection 199.33 10.39 117 99327 2637 32411445
Procedural pain 196.84 10.39 150 99294 5279 32408803
Drug abuse 175.54 10.39 20 99424 80223 32333859
Cardiac failure congestive 168.04 10.39 606 98838 84246 32329836
Hypotension 167.97 10.39 1183 98261 214927 32199155
Hypokalaemia 154.09 10.39 443 99001 54651 32359431
Cardiac arrest 149.34 10.39 639 98805 96137 32317945
Peritoneal cloudy effluent 141.77 10.39 53 99391 398 32413684
Cardiac disorder 137.35 10.39 357 99087 41509 32372573
Off label use 136.94 10.39 480 98964 305840 32108242
Diabetic foot 129.04 10.39 91 99353 2835 32411247
Fluid retention 128.62 10.39 264 99180 26286 32387796
Cardiac failure 118.79 10.39 575 98869 91098 32322984
Dehydration 113.16 10.39 728 98716 128230 32285852
Multimorbidity 109.19 10.39 47 99397 528 32413554
Drug interaction 106.23 10.39 329 99115 217856 32196226
Inadequate aseptic technique in use of product 102.28 10.39 33 99411 149 32413933
Hypervolaemia 99.70 10.39 74 99370 2500 32411582
Device related infection 97.30 10.39 187 99257 17746 32396336
Hernia 93.73 10.39 130 99314 9385 32404697
Rheumatoid arthritis 92.77 10.39 13 99431 44531 32369551
Toxicity to various agents 91.27 10.39 262 99182 177779 32236303
Disease complication 91.13 10.39 73 99371 2766 32411316
Cardiovascular disorder 87.09 10.39 134 99310 10628 32403454
Cardio-respiratory arrest 85.72 10.39 369 99075 55620 32358462
Inguinal hernia 84.93 10.39 113 99331 7839 32406243
Fluid imbalance 83.35 10.39 36 99408 408 32413674
Appendicolith 76.22 10.39 69 99375 3096 32410986
Headache 76.16 10.39 325 99119 195872 32218210
Acute myocardial infarction 73.60 10.39 349 99095 54800 32359282
Suicide attempt 69.19 10.39 16 99428 38228 32375854
Diabetic complication 65.88 10.39 39 99405 893 32413189
Noninfectious peritonitis 63.24 10.39 25 99419 222 32413860
Azotaemia 63.06 10.39 80 99364 5294 32408788
Arthralgia 62.55 10.39 238 99206 148210 32265872
Myocardial infarction 62.52 10.39 623 98821 125053 32289029
Psoriasis 61.66 10.39 32 99412 46091 32367991
Treatment failure 60.55 10.39 22 99422 39141 32374941
Therapeutic product effect incomplete 59.37 10.39 26 99418 41315 32372767
Peritoneal disorder 59.26 10.39 28 99416 397 32413685
Pneumonia 59.19 10.39 1462 97982 353790 32060292
Myelosuppression 58.78 10.39 118 99326 11558 32402524
Cardiogenic shock 58.53 10.39 167 99277 20495 32393587
Heparin-induced thrombocytopenia 56.17 10.39 78 99366 5636 32408446
Blood potassium decreased 55.95 10.39 147 99297 17191 32396891
Umbilical hernia 55.63 10.39 67 99377 4203 32409879
Peritoneal effluent abnormal 54.94 10.39 20 99424 138 32413944
Pulmonary oedema 54.75 10.39 283 99161 45984 32368098
Overdose 52.38 10.39 118 99326 86959 32327123
Device occlusion 50.79 10.39 82 99362 6776 32407306
Injection site pain 50.38 10.39 19 99425 33039 32381043
Abdominal pain 50.15 10.39 687 98757 148842 32265240
Product use in unapproved indication 44.84 10.39 128 99316 87076 32327006
Appendicitis 44.60 10.39 90 99354 8847 32405235
Hyperkalaemia 42.87 10.39 362 99082 69388 32344694
Drug reaction with eosinophilia and systemic symptoms 42.73 10.39 23 99421 32462 32381620
Administration site extravasation 42.26 10.39 24 99420 507 32413575
Incision site pain 40.61 10.39 40 99404 1997 32412085
Myalgia 40.48 10.39 121 99323 81109 32332973
Multiple organ dysfunction syndrome 39.01 10.39 355 99089 69499 32344583
Intentional product misuse 38.71 10.39 32 99412 36019 32378063
Gangrene 38.39 10.39 60 99384 4822 32409260
Hydrothorax 36.43 10.39 22 99422 523 32413559
Treatment noncompliance 34.00 10.39 169 99275 27033 32387049
Suicidal ideation 33.76 10.39 40 99404 38043 32376039
Drug resistance 33.68 10.39 14 99430 22951 32391131
Fatigue 33.00 10.39 819 98625 349882 32064200
Cardiac procedure complication 32.88 10.39 16 99428 243 32413839
Drug intolerance 32.77 10.39 65 99379 50170 32363912
Serotonin syndrome 32.64 10.39 9 99435 19108 32394974
Mental status changes 32.05 10.39 214 99230 38123 32375959
Asthma 31.42 10.39 54 99390 44011 32370071
Localised infection 31.30 10.39 110 99334 15077 32399005
Angioedema 31.23 10.39 39 99405 36250 32377832
Malnutrition 31.20 10.39 96 99348 12282 32401800
Aggression 31.19 10.39 45 99399 39344 32374738
Depression 31.07 10.39 172 99272 96888 32317194
Somnolence 31.05 10.39 188 99256 103609 32310473
Failure to thrive 30.85 10.39 75 99369 8360 32405722
Oedema 30.80 10.39 240 99204 44907 32369175
Intentional product use issue 30.77 10.39 51 99393 42160 32371922
Insomnia 30.42 10.39 181 99263 100167 32313915
Joint swelling 29.58 10.39 72 99372 51663 32362419
Spinal muscular atrophy 29.36 10.39 16 99428 311 32413771
Intentional overdose 28.74 10.39 52 99392 41549 32372533
Musculoskeletal stiffness 28.10 10.39 48 99396 39216 32374866
Staphylococcus test positive 27.87 10.39 41 99403 3124 32410958
Gastrointestinal haemorrhage 27.79 10.39 396 99048 86486 32327596
Abdominal hernia 27.70 10.39 39 99405 2854 32411228
Rash 27.66 10.39 462 98982 208871 32205211
Drug dependence 27.57 10.39 19 99425 23465 32390617
Cytokine release syndrome 27.01 10.39 97 99347 13438 32400644
Mycobacterial peritonitis 26.99 10.39 9 99435 46 32414036
Interstitial lung disease 26.82 10.39 105 99339 64896 32349186
Product use issue 26.73 10.39 78 99366 52699 32361383
Complication associated with device 26.63 10.39 58 99386 6014 32408068
Loss of personal independence in daily activities 26.20 10.39 26 99418 26807 32387275
Blood glucose decreased 26.17 10.39 96 99348 13438 32400644
Diaphragmatic spasm 25.99 10.39 10 99434 82 32414000
Blood urea increased 25.69 10.39 178 99266 32095 32381987
Lower respiratory tract infection 25.61 10.39 31 99413 29212 32384870
Respiratory failure 25.12 10.39 464 98980 106718 32307364
Cerebrovascular accident 25.09 10.39 387 99057 85933 32328149
Faecal volume decreased 24.61 10.39 10 99434 96 32413986
Eosinophilia 24.58 10.39 24 99420 24934 32389148
Sedation 24.53 10.39 13 99431 18513 32395569
Anxiety 23.69 10.39 184 99260 95821 32318261
Tachypnoea 23.68 10.39 108 99336 16675 32397407
Asthenia 23.33 10.39 912 98532 235032 32179050
Constipation 23.31 10.39 528 98916 125845 32288237
Disturbance in attention 23.21 10.39 23 99421 23730 32390352
Osteonecrosis of jaw 23.18 10.39 15 99429 19151 32394931
Sopor 23.16 10.39 4 99440 11745 32402337
Therapeutic product effect decreased 23.05 10.39 37 99407 30980 32383102
Contraindicated product administered 22.98 10.39 15 99429 19061 32395021
Psoriatic arthropathy 22.97 10.39 13 99431 17847 32396235
Hypoglycaemia 22.97 10.39 261 99183 54121 32359961
Intentional self-injury 22.89 10.39 7 99437 13893 32400189
Right ventricular failure 22.61 10.39 67 99377 8396 32405686
Inappropriate schedule of product administration 22.29 10.39 69 99375 45756 32368326
Therapeutic response decreased 22.15 10.39 28 99416 25892 32388190
Completed suicide 22.05 10.39 179 99265 92338 32321744
Product substitution issue 21.83 10.39 3 99441 10433 32403649
Gait disturbance 21.32 10.39 151 99293 80257 32333825
Calciphylaxis 21.13 10.39 22 99422 1174 32412908
Hip fracture 21.11 10.39 82 99362 11793 32402289
Extremity necrosis 20.85 10.39 27 99417 1823 32412259
Blood potassium increased 20.71 10.39 104 99340 16700 32397382
Sputum increased 20.46 10.39 29 99415 2136 32411946
Ascites 20.30 10.39 200 99244 39991 32374091
Cytomegalovirus infection 20.25 10.39 29 99415 25435 32388647
Swelling 20.19 10.39 192 99252 38030 32376052
Ureteric compression 20.15 10.39 12 99432 278 32413804
Withdrawal of life support 20.02 10.39 6 99438 20 32414062
Pleuroperitoneal communication 19.92 10.39 7 99437 43 32414039
Wrong product administered 19.83 10.39 46 99398 4974 32409108
Dyskinesia 19.65 10.39 26 99418 23577 32390505
Hospitalisation 19.63 10.39 80 99364 48891 32365191
Respiratory tract infection bacterial 19.51 10.39 16 99428 627 32413455
Cognitive disorder 19.13 10.39 31 99413 25863 32388219
Hypernatraemia 19.05 10.39 62 99382 8171 32405911
Foetal exposure during pregnancy 18.82 10.39 64 99380 41237 32372845
Hepatotoxicity 18.58 10.39 19 99425 19318 32394764
Psychotic disorder 18.52 10.39 26 99418 22994 32391088
Peripheral vascular disorder 18.35 10.39 46 99398 5226 32408856
Diabetic ulcer 18.30 10.39 9 99435 140 32413942
Product prescribing error 18.24 10.39 20 99424 19697 32394385
Urticaria 17.80 10.39 108 99336 59506 32354576
Epilepsy 17.75 10.39 25 99419 22084 32391998
Oropharyngeal pain 17.63 10.39 44 99400 31308 32382774
Osteonecrosis 17.54 10.39 15 99429 16607 32397475
Marasmus 17.53 10.39 15 99429 624 32413458
Hallucination 17.51 10.39 92 99352 52527 32361555
Neutropenia 17.40 10.39 318 99126 141857 32272225
Tremor 17.26 10.39 162 99282 81115 32332967
International normalised ratio increased 17.09 10.39 227 99217 48808 32365274
Red blood cells urine positive 16.99 10.39 24 99420 1762 32412320
Catheter site extravasation 16.96 10.39 8 99436 113 32413969
Cardiomyopathy 16.93 10.39 95 99349 15918 32398164
Sinusitis 16.43 10.39 57 99387 36503 32377579
Diabetic vascular disorder 16.23 10.39 7 99437 79 32414003
Cardiovascular insufficiency 16.11 10.39 22 99422 1564 32412518
Rhabdomyolysis 16.09 10.39 130 99314 67135 32346947
Metabolic alkalosis 16.05 10.39 21 99423 1433 32412649
Extravasation 15.82 10.39 24 99420 1879 32412203
Pruritus 15.70 10.39 288 99156 128414 32285668
Dizziness 15.69 10.39 505 98939 209113 32204969
Mood swings 15.62 10.39 3 99441 8162 32405920
Oedema peripheral 15.56 10.39 458 98986 113633 32300449
Atrial fibrillation 15.51 10.39 467 98977 116237 32297845
Hepatocellular carcinoma 15.48 10.39 6 99438 10264 32403818
Immune reconstitution inflammatory syndrome 15.41 10.39 5 99439 9554 32404528
Depressed mood 15.40 10.39 20 99424 18280 32395802
Withdrawal syndrome 15.34 10.39 9 99435 12113 32401969
Vertigo 15.34 10.39 32 99412 24251 32389831
Prescribed overdose 15.31 10.39 5 99439 9514 32404568
Feeling abnormal 15.28 10.39 115 99329 60308 32353774
Therapeutic product effect prolonged 15.27 10.39 10 99434 275 32413807
Rash maculo-papular 15.24 10.39 40 99404 27982 32386100
Bacterial translocation 15.21 10.39 10 99434 277 32413805
Pneumococcal sepsis 15.02 10.39 16 99428 877 32413205
Paraesthesia 14.99 10.39 112 99332 58832 32355250
Generalised tonic-clonic seizure 14.98 10.39 25 99419 20614 32393468
Scrotal swelling 14.93 10.39 20 99424 1396 32412686
Visual acuity reduced 14.86 10.39 17 99427 16428 32397654
Mental impairment 14.85 10.39 6 99438 10006 32404076
Schizophrenia 14.78 10.39 6 99438 9978 32404104
Dystonia 14.75 10.39 7 99437 10616 32403466
Arthropathy 14.75 10.39 29 99415 22460 32391622
Injection site bruising 14.69 10.39 3 99441 7817 32406265
Pseudomonas test positive 14.65 10.39 17 99427 1025 32413057
Bacteraemia 14.47 10.39 98 99346 17535 32396547
Blood albumin decreased 14.47 10.39 78 99366 12875 32401207
Product contamination microbial 14.21 10.39 14 99430 699 32413383
Osteoarthritis 14.20 10.39 24 99420 19695 32394387
Dyspnoea 14.16 10.39 1288 98156 360757 32053325
Squamous cell carcinoma 14.08 10.39 8 99436 10960 32403122
Sensory integrative dysfunction 14.06 10.39 5 99439 32 32414050
Pain 14.00 10.39 452 98992 187104 32226978
Emotional disorder of childhood 13.93 10.39 5 99439 33 32414049
Mania 13.92 10.39 6 99438 9626 32404456
Polyneuropathy 13.85 10.39 12 99432 13203 32400879
Stress 13.84 10.39 122 99322 23660 32390422
Arthritis 13.84 10.39 39 99405 26653 32387429
Pathogen resistance 13.62 10.39 6 99438 9504 32404578
Product container issue 13.60 10.39 15 99429 855 32413227
Pneumocystis jirovecii pneumonia 13.56 10.39 23 99421 18847 32395235
Leukopenia 13.56 10.39 118 99326 60004 32354078
Intercepted medication error 13.51 10.39 12 99432 525 32413557
Shoshin beriberi 13.44 10.39 6 99438 74 32414008
Urinary tract infection 13.36 10.39 330 99114 79741 32334341
Memory impairment 13.34 10.39 71 99373 40408 32373674
Tendonitis 13.34 10.39 5 99439 8730 32405352
Nosocomial infection 13.32 10.39 18 99426 1267 32412815
Face oedema 13.20 10.39 10 99434 11765 32402317
General physical health deterioration 13.18 10.39 453 98991 114806 32299276
Blood glucose increased 13.10 10.39 276 99168 64965 32349117
Abdominal discomfort 13.08 10.39 230 99214 52394 32361688
Lymphadenopathy 13.01 10.39 41 99403 27041 32387041
Postoperative wound infection 13.00 10.39 38 99406 4726 32409356
Product storage error 12.99 10.39 3 99441 7175 32406907
Blood pressure decreased 12.96 10.39 224 99220 50856 32363226
Increased bronchial secretion 12.96 10.39 21 99423 1740 32412342
Peritoneal perforation 12.89 10.39 5 99439 42 32414040
Body temperature decreased 12.81 10.39 9 99435 11005 32403077
Red blood cell sedimentation rate increased 12.81 10.39 4 99440 7831 32406251
Irritability 12.80 10.39 36 99408 24618 32389464
Infusion site necrosis 12.78 10.39 4 99440 16 32414066
Glycosylated haemoglobin increased 12.74 10.39 8 99436 10381 32403701
Erectile dysfunction 12.65 10.39 26 99418 19813 32394269
Vocal cord paralysis 12.58 10.39 15 99429 931 32413151
Bone marrow failure 12.42 10.39 145 99299 30259 32383823
Obstructive airways disorder 12.37 10.39 11 99433 11950 32402132
Hyperinsulinaemia 12.34 10.39 6 99438 91 32413991
Gastric ischaemia 12.31 10.39 3 99441 3 32414079
Mesenteric artery stenosis 12.23 10.39 4 99440 19 32414063
Posthaemorrhagic hydrocephalus 12.22 10.39 6 99438 93 32413989
Limb discomfort 12.21 10.39 8 99436 10146 32403936
Post procedural complication 12.16 10.39 70 99374 11837 32402245
Drug hypersensitivity 12.10 10.39 155 99289 73245 32340837
Erythema 12.09 10.39 180 99264 82925 32331157
Swelling of eyelid 12.03 10.39 11 99433 500 32413582
Gamma-glutamyltransferase increased 11.89 10.39 51 99393 30731 32383351
Lung consolidation 11.89 10.39 40 99404 5363 32408719
Product preparation error 11.87 10.39 21 99423 1869 32412213
Pleural effusion 11.85 10.39 321 99123 78671 32335411
Device related sepsis 11.83 10.39 25 99419 2538 32411544
Application site laceration 11.75 10.39 4 99440 22 32414060
Drug withdrawal syndrome 11.68 10.39 28 99416 20203 32393879
Toxic epidermal necrolysis 11.66 10.39 105 99339 20488 32393594
Herpes zoster 11.64 10.39 55 99389 32286 32381796
Hepatic enzyme increased 11.64 10.39 66 99378 36971 32377111
Angina pectoris 11.58 10.39 53 99391 31373 32382709
Panic attack 11.54 10.39 7 99437 9254 32404828
Blood pressure increased 11.50 10.39 172 99272 79182 32334900
Prostate cancer 11.47 10.39 44 99400 27362 32386720
Haemoglobin decreased 11.42 10.39 461 98983 119210 32294872
Septic shock 11.41 10.39 284 99160 68705 32345377
Ileus 11.38 10.39 87 99357 16178 32397904
Injection site erythema 11.37 10.39 17 99427 14651 32399431
Delusion 11.37 10.39 14 99430 13094 32400988
Pulmonary hypertension 11.35 10.39 104 99340 20390 32393692
Acute respiratory failure 11.29 10.39 136 99308 28592 32385490
Hyperinsulinaemic hypoglycaemia 11.25 10.39 5 99439 61 32414021
Cellulitis 11.25 10.39 216 99228 50014 32364068
Basal cell carcinoma 11.22 10.39 23 99421 17545 32396537
Nasopharyngitis 11.16 10.39 133 99311 63654 32350428
Hepatitis C 11.14 10.39 15 99429 13503 32400579
Lymphocyte count decreased 11.11 10.39 106 99338 21013 32393069
Anger 11.09 10.39 12 99432 11892 32402190
Paranoia 11.08 10.39 10 99434 10789 32403293
Dysarthria 11.07 10.39 58 99386 33143 32380939
Photosensitivity reaction 10.93 10.39 9 99435 10154 32403928
Injection site swelling 10.93 10.39 8 99436 9576 32404506
Mucosal inflammation 10.82 10.39 59 99385 33375 32380707
Blood creatine phosphokinase increased 10.82 10.39 88 99356 45388 32368694
Renal tubular acidosis 10.79 10.39 21 99423 2011 32412071
Atrial septal defect 10.76 10.39 4 99440 7021 32407061
Mood altered 10.73 10.39 7 99437 8897 32405185
Atelectasis 10.72 10.39 88 99356 16720 32397362
Pneumoperitoneum 10.71 10.39 20 99424 1856 32412226
Product contamination 10.67 10.39 12 99432 699 32413383
Sexual dysfunction 10.66 10.39 3 99441 6286 32407796
Incorrect drug administration rate 10.66 10.39 16 99428 1241 32412841
Hydrocele 10.63 10.39 22 99422 2202 32411880
Ventricular tachycardia 10.49 10.39 122 99322 25434 32388648
Suprapubic pain 10.44 10.39 9 99435 378 32413704
Injection site reaction 10.41 10.39 12 99432 11557 32402525

Pharmacologic Action:

SourceCodeDescription
ATC B05CX01 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
IRRIGATING SOLUTIONS
Other irrigating solutions
ATC C05BB56 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
ANTIVARICOSE THERAPY
Sclerosing agents for local injection
ATC V04CA02 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Tests for diabetes
ATC V06DC01 VARIOUS
GENERAL NUTRIENTS
OTHER NUTRIENTS
Carbohydrates
CHEBI has role CHEBI:75771 Mus musculus metabolite
CHEBI has role CHEBI:75772 bakers yeast metabolite
CHEBI has role CHEBI:76971 E.coli metabolites
CHEBI has role CHEBI:77746 H. sapiens metabolites
MeSH PA D005421 Flavoring Agents
MeSH PA D005503 Food Additives
MeSH PA D013549 Sweetening Agents
CHEBI has role CHEBI:78675 essential metabolite

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypoglycemia indication 302866003 DOID:9993

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.87 acidic
pKa2 13.08 acidic
pKa3 13.91 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019541 VUID
N0000147647 NUI
D00009 KEGG_DRUG
77938-63-7 SECONDARY_CAS_RN
4017760 VANDF
4019541 VANDF
C0017725 UMLSCUI
CHEBI:4167 CHEBI
GLO PDB_CHEM_ID
CHEMBL1222250 ChEMBL_ID
CHEMBL1614854 ChEMBL_ID
D005947 MESH_DESCRIPTOR_UI
DB09341 DRUGBANK_ID
4536 IUPHAR_LIGAND_ID
LX22YL083G UNII
5793 PUBCHEM_CID
DB01914 DRUGBANK_ID
1299920 RXNORM
11133 MMSL
4567 MMSL
4787 MMSL
71873 MMSL
71874 MMSL
9763 MMSL
d00595 MMSL
000915 NDDF
002597 NDDF
111138002 SNOMEDCT_US
67079006 SNOMEDCT_US
725859007 SNOMEDCT_US
768547002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0264-1290 INJECTION, SOLUTION 70 g INTRAVENOUS UNAPPROVED DRUG OTHER 24 sections
Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0264-1510 INJECTION, SOLUTION 50 mg INTRAVENOUS NDA 24 sections
MYOCARD-DX HUMAN PRESCRIPTION DRUG LABEL 2 0264-1840 INJECTION 5 g INTRAVENOUS EXPORT ONLY 20 sections
MYOCARD-DX HUMAN PRESCRIPTION DRUG LABEL 2 0264-1880 INJECTION 5 g INTRAVENOUS EXPORT ONLY 20 sections
Isolyte P in Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0264-7730 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 23 sections
Dextrose in Lactated Ringers HUMAN PRESCRIPTION DRUG LABEL 5 0264-7751 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 22 sections
Theophylline in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9554 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 27 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9567 INJECTION 5 g INTRAVENOUS NDA 19 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9577 INJECTION 5 g INTRAVENOUS NDA 19 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9587 INJECTION 5 g INTRAVENOUS NDA 19 sections
Lidocaine Hydrochloride and Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9594 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 23 sections
Lidocaine Hydrochloride and Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9598 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 23 sections
DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0017 INJECTION, SOLUTION 50 g INTRAVENOUS NDA 21 sections
DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0023 INJECTION, SOLUTION 100 g INTRAVENOUS NDA 21 sections
DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0062 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 21 sections
DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0066 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 21 sections
DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0070 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 21 sections
Dextrose and Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 2 0338-0073 INJECTION, SOLUTION 2.50 g INTRAVENOUS NDA 21 sections
DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0074 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 21 sections
Dextrose and Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 2 0338-0077 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 21 sections
DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0078 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 21 sections
Dextrose and Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 2 0338-0081 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 21 sections
DEXTROSE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0082 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 21 sections
Dextrose and Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 2 0338-0085 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 21 sections
Dextrose and Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 2 0338-0089 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 21 sections
Lactated Ringers and Dextrose HUMAN PRESCRIPTION DRUG LABEL 5 0338-0125 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 18 sections
Dextrose and Electrolyte No. 48 HUMAN PRESCRIPTION DRUG LABEL 6 0338-0143 INJECTION 5 g INTRAVENOUS NDA 19 sections
Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0338-0551 INJECTION 5 g INTRAVENOUS NDA 21 sections
Potassium Chloride in Dextrose and Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 3 0338-0603 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 21 sections
Potassium Chloride in Dextrose and Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 3 0338-0663 INJECTION, SOLUTION 5 g INTRAVENOUS NDA 21 sections