dexpanthenol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
838 81-13-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexpanthenol
  • (+)-panthenol
  • bepanthen
  • D-Panthenol
The alcohol of pantothenic acid
  • Molecular weight: 205.25
  • Formula: C9H19NO4
  • CLOGP: -1.65
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 4
  • TPSA: 89.79
  • ALOGS: -0.23
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia aspiration 195.59 16.42 80 4808 34460 63449674
Gastrooesophageal reflux disease 148.43 16.42 92 4796 95547 63388587
Coma 134.24 16.42 75 4813 64289 63419845
Somnolence 82.25 16.42 84 4804 178601 63305533
Underdose 41.42 16.42 26 4862 27430 63456704
Intestinal haemorrhage 36.48 16.42 13 4875 3834 63480300
Female genital tract fistula 34.34 16.42 15 4873 7544 63476590
Pulmonary vein occlusion 33.34 16.42 6 4882 105 63484029
Chronic sinusitis 29.55 16.42 16 4872 12827 63471307
Vaginal flatulence 27.01 16.42 10 4878 3283 63480851
Tumour pain 26.37 16.42 8 4880 1429 63482705
Optic nerve disorder 25.39 16.42 7 4881 892 63483242
Toxic epidermal necrolysis 23.98 16.42 18 4870 25316 63458818
Anterior segment ischaemia 23.13 16.42 4 4884 55 63484079
Incorrect route of product administration 22.70 16.42 18 4870 27434 63456700
Proctitis 22.16 16.42 10 4878 5431 63478703
Hepatic cirrhosis 22.14 16.42 17 4871 24717 63459417
Radiculopathy 20.57 16.42 11 4877 8600 63475534
Neuropathy peripheral 18.30 16.42 32 4856 113635 63370499
Colitis 17.32 16.42 20 4868 48508 63435626
Vaginal discharge 17.19 16.42 10 4878 9188 63474946
Venous thrombosis limb 17.10 16.42 7 4881 3001 63481133
Oral candidiasis 16.84 16.42 14 4874 22784 63461350

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile bone marrow aplasia 41.13 20.47 17 2443 8192 34946279
Generalised oedema 37.40 20.47 18 2442 12390 34942081
Face oedema 35.60 20.47 17 2443 11499 34942972
General physical health deterioration 31.82 20.47 42 2418 128227 34826244
Anaemia 25.80 20.47 53 2407 233282 34721189
Dysuria 22.11 20.47 17 2443 27135 34927336

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastrooesophageal reflux disease 100.47 15.77 78 6739 104168 79633403
Pneumonia aspiration 94.06 15.77 63 6754 66904 79670667
Coma 59.55 15.77 57 6760 100592 79636979
Somnolence 54.07 15.77 83 6734 238898 79498673
Female genital tract fistula 36.22 15.77 15 6802 5960 79731611
Underdose 34.50 15.77 26 6791 33125 79704446
Incorrect route of product administration 31.15 15.77 25 6792 34904 79702667
Pulmonary vein occlusion 30.95 15.77 6 6811 143 79737428
Intestinal haemorrhage 28.69 15.77 13 6804 6413 79731158
Vaginal flatulence 28.39 15.77 10 6807 2565 79735006
Chronic sinusitis 27.77 15.77 16 6801 13010 79724561
Anaemia 25.74 15.77 90 6727 444925 79292646
Tumour pain 25.62 15.77 9 6808 2290 79735281
Anterior segment ischaemia 22.71 15.77 4 6813 55 79737516
Proctitis 22.51 15.77 11 6806 6421 79731150
Optic nerve disorder 22.24 15.77 7 6810 1270 79736301
Radiculopathy 21.97 15.77 12 6805 8812 79728759
Hepatic cirrhosis 21.06 15.77 20 6797 34886 79702685
Toxic epidermal necrolysis 20.40 15.77 22 6795 44559 79693012
Febrile bone marrow aplasia 20.08 15.77 13 6804 13007 79724564
General physical health deterioration 18.86 15.77 59 6758 275179 79462392
Metastases to meninges 18.37 15.77 8 6809 3593 79733978
Vaginal discharge 18.17 15.77 10 6807 7453 79730118
Stevens-Johnson syndrome 17.35 15.77 19 6798 39147 79698424
Appendicolith 16.90 15.77 10 6807 8541 79729030
Breast cancer metastatic 16.84 15.77 10 6807 8592 79728979
Venous thrombosis limb 16.74 15.77 8 6809 4449 79733122
Macular degeneration 16.73 15.77 11 6806 11285 79726286
Breast cancer 16.04 15.77 17 6800 33764 79703807

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA30 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
ATC D03AX03 DERMATOLOGICALS
PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
CICATRIZANTS
Other cicatrizants
ATC S01XA12 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
CHEBI has role CHEBI:38323 cholinergic drugs
CHEBI has role CHEBI:50188 provitamins

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Eczema indication 43116000
Toxicodendron radicans indication 52352005
Paralytic ileus indication 55525008 DOID:8442
Diaper rash indication 91487003
Disorder of skin indication 95320005 DOID:37
Contact dermatitis due to poison oak indication 200824008
Gastroparesis indication 235675006
Arthropod bite wound indication 409985002
Paralytic Ileus Prevention indication
Chafing of skin off-label use 238474002
Eruption of skin off-label use 271807003 DOID:0050486
Skin irritation off-label use 367466007
Itching of skin off-label use 418363000
Hemophilia contraindication 90935002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.71 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4020828 VUID
N0000146036 NUI
22701 RXNORM
4017657 VANDF
4020828 VANDF
C0057610 UMLSCUI
CHEBI:27373 CHEBI
CHEMBL1200979 ChEMBL_ID
DB09357 DRUGBANK_ID
131204 PUBCHEM_CID
C007288 MESH_SUPPLEMENTAL_RECORD_UI
1023 INN_ID
1O6C93RI7Z UNII
1536 MMSL
4558 MMSL
d01001 MMSL
001696 NDDF
126226000 SNOMEDCT_US
404842009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
B-PLEX 100 HUMAN PRESCRIPTION DRUG LABEL 5 30727-300 INJECTION, SOLUTION 2 mg INTRAMUSCULAR unapproved drug other 10 sections
HASOL Anagen Hair Tonic HUMAN OTC DRUG LABEL 3 51270-122 LIQUID 0.00 1 TOPICAL unapproved drug other 8 sections
HASOL Anagen Scalp HUMAN OTC DRUG LABEL 3 51270-123 SHAMPOO 0.00 1 TOPICAL unapproved drug other 8 sections
HASOL Anti Hair Loss HUMAN OTC DRUG LABEL 3 51270-124 SHAMPOO 0.00 1 TOPICAL unapproved drug other 8 sections
HASOL Vital For Hair-Loss Tonic HUMAN OTC DRUG LABEL 3 51270-125 LIQUID 0.00 1 TOPICAL unapproved drug other 8 sections
PEDIATRIC INFUVITE MULTIPLE VITAMINS FOR INFUSION HUMAN PRESCRIPTION DRUG LABEL 13 54643-5646 INJECTION, SOLUTION 5 mg INTRAVENOUS NDA 19 sections
PEDIATRIC INFUVITE MULTIPLE VITAMINS FOR INFUSION HUMAN PRESCRIPTION DRUG LABEL 13 54643-5646 INJECTION, SOLUTION 5 mg INTRAVENOUS NDA 19 sections
Adult Infuvite Multiple Vitamins for Infusion HUMAN PRESCRIPTION DRUG LABEL 13 54643-5649 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 17 sections
Adult Infuvite Multiple Vitamins for Infusion HUMAN PRESCRIPTION DRUG LABEL 13 54643-5649 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 17 sections
Adult Infuvite Multiple Vitamins for Infusion HUMAN PRESCRIPTION DRUG LABEL 13 54643-5649 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 17 sections
Infuvite Adult Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-5650 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Infuvite Adult Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-5650 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-7862 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-7862 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-7874 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-7874 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Pediatric Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-7886 INJECTION, SOLUTION 5 mg INTRAVENOUS NDA 19 sections
Pediatric Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-7886 INJECTION, SOLUTION 5 mg INTRAVENOUS NDA 19 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9007 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9007 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9015 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9015 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Pediatric Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9023 INJECTION, SOLUTION 5 mg INTRAVENOUS NDA 19 sections
Pediatric Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9023 INJECTION, SOLUTION 5 mg INTRAVENOUS NDA 19 sections
Vitamin B Complex HUMAN PRESCRIPTION DRUG LABEL 5 67457-146 INJECTION 2 mg INTRAVENOUS Unapproved drug other 9 sections
NDM SCALP HUMAN OTC DRUG LABEL 4 69288-001 SHAMPOO 1.40 g TOPICAL unapproved drug other 11 sections
YOZUM WELL BEING HAIR COLOR HUMAN OTC DRUG LABEL 1 69525-2001 LIQUID 0.20 g TOPICAL OTC monograph not final 7 sections
Notamo Hair Tonic HUMAN OTC DRUG LABEL 2 69709-102 LIQUID 0.20 1 TOPICAL unapproved drug other 8 sections
Vitamin B Complex HUMAN PRESCRIPTION DRUG LABEL 5 69877-026 INJECTION, SOLUTION 2 mg INTRAMUSCULAR unapproved drug other 10 sections
B-Combo HUMAN PRESCRIPTION DRUG LABEL 6 70104-110 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections