dexpanthenol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	838	81-13-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: dexpanthenol (+)-panthenol bepanthen D-Panthenol	The alcohol of pantothenic acid Molecular weight: 205.25 Formula: C9H19NO4 CLOGP: -1.65 LIPINSKI: 0 HAC: 5 HDO: 4 TPSA: 89.79 ALOGS: -0.23 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

dexpanthenol
(+)-panthenol
bepanthen
D-Panthenol

The alcohol of pantothenic acid

Molecular weight: 205.25
Formula: C9H19NO4
CLOGP: -1.65
LIPINSKI: 0
HAC: 5
HDO: 4
TPSA: 89.79
ALOGS: -0.23
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Feb. 20, 1953	FDA	HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pneumonia aspiration	195.59	16.42	80	4808	34460	63449674
Gastrooesophageal reflux disease	148.43	16.42	92	4796	95547	63388587
Coma	134.24	16.42	75	4813	64289	63419845
Somnolence	82.25	16.42	84	4804	178601	63305533
Underdose	41.42	16.42	26	4862	27430	63456704
Intestinal haemorrhage	36.48	16.42	13	4875	3834	63480300
Female genital tract fistula	34.34	16.42	15	4873	7544	63476590
Pulmonary vein occlusion	33.34	16.42	6	4882	105	63484029
Chronic sinusitis	29.55	16.42	16	4872	12827	63471307
Vaginal flatulence	27.01	16.42	10	4878	3283	63480851
Tumour pain	26.37	16.42	8	4880	1429	63482705
Optic nerve disorder	25.39	16.42	7	4881	892	63483242
Toxic epidermal necrolysis	23.98	16.42	18	4870	25316	63458818
Anterior segment ischaemia	23.13	16.42	4	4884	55	63484079
Incorrect route of product administration	22.70	16.42	18	4870	27434	63456700
Proctitis	22.16	16.42	10	4878	5431	63478703
Hepatic cirrhosis	22.14	16.42	17	4871	24717	63459417
Radiculopathy	20.57	16.42	11	4877	8600	63475534
Neuropathy peripheral	18.30	16.42	32	4856	113635	63370499
Colitis	17.32	16.42	20	4868	48508	63435626
Vaginal discharge	17.19	16.42	10	4878	9188	63474946
Venous thrombosis limb	17.10	16.42	7	4881	3001	63481133
Oral candidiasis	16.84	16.42	14	4874	22784	63461350

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile bone marrow aplasia	41.13	20.47	17	2443	8192	34946279
Generalised oedema	37.40	20.47	18	2442	12390	34942081
Face oedema	35.60	20.47	17	2443	11499	34942972
General physical health deterioration	31.82	20.47	42	2418	128227	34826244
Anaemia	25.80	20.47	53	2407	233282	34721189
Dysuria	22.11	20.47	17	2443	27135	34927336

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Gastrooesophageal reflux disease	100.47	15.77	78	6739	104168	79633403
Pneumonia aspiration	94.06	15.77	63	6754	66904	79670667
Coma	59.55	15.77	57	6760	100592	79636979
Somnolence	54.07	15.77	83	6734	238898	79498673
Female genital tract fistula	36.22	15.77	15	6802	5960	79731611
Underdose	34.50	15.77	26	6791	33125	79704446
Incorrect route of product administration	31.15	15.77	25	6792	34904	79702667
Pulmonary vein occlusion	30.95	15.77	6	6811	143	79737428
Intestinal haemorrhage	28.69	15.77	13	6804	6413	79731158
Vaginal flatulence	28.39	15.77	10	6807	2565	79735006
Chronic sinusitis	27.77	15.77	16	6801	13010	79724561
Anaemia	25.74	15.77	90	6727	444925	79292646
Tumour pain	25.62	15.77	9	6808	2290	79735281
Anterior segment ischaemia	22.71	15.77	4	6813	55	79737516
Proctitis	22.51	15.77	11	6806	6421	79731150
Optic nerve disorder	22.24	15.77	7	6810	1270	79736301
Radiculopathy	21.97	15.77	12	6805	8812	79728759
Hepatic cirrhosis	21.06	15.77	20	6797	34886	79702685
Toxic epidermal necrolysis	20.40	15.77	22	6795	44559	79693012
Febrile bone marrow aplasia	20.08	15.77	13	6804	13007	79724564
General physical health deterioration	18.86	15.77	59	6758	275179	79462392
Metastases to meninges	18.37	15.77	8	6809	3593	79733978
Vaginal discharge	18.17	15.77	10	6807	7453	79730118
Stevens-Johnson syndrome	17.35	15.77	19	6798	39147	79698424
Appendicolith	16.90	15.77	10	6807	8541	79729030
Breast cancer metastatic	16.84	15.77	10	6807	8592	79728979
Venous thrombosis limb	16.74	15.77	8	6809	4449	79733122
Macular degeneration	16.73	15.77	11	6806	11285	79726286
Breast cancer	16.04	15.77	17	6800	33764	79703807

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A11HA30	ALIMENTARY TRACT AND METABOLISM VITAMINS OTHER PLAIN VITAMIN PREPARATIONS Other plain vitamin preparations
ATC	D03AX03	DERMATOLOGICALS PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS CICATRIZANTS Other cicatrizants
ATC	S01XA12	SENSORY ORGANS OPHTHALMOLOGICALS OTHER OPHTHALMOLOGICALS Other ophthalmologicals
CHEBI has role	CHEBI:38323	cholinergic drugs
CHEBI has role	CHEBI:50188	provitamins

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Eczema	indication	43116000
Toxicodendron radicans	indication	52352005
Paralytic ileus	indication	55525008	DOID:8442
Diaper rash	indication	91487003
Disorder of skin	indication	95320005	DOID:37
Contact dermatitis due to poison oak	indication	200824008
Gastroparesis	indication	235675006
Arthropod bite wound	indication	409985002
Paralytic Ileus Prevention	indication
Chafing of skin	off-label use	238474002
Eruption of skin	off-label use	271807003	DOID:0050486
Skin irritation	off-label use	367466007
Itching of skin	off-label use	418363000
Hemophilia	contraindication	90935002

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.71	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4020828	VUID
N0000146036	NUI
22701	RXNORM
4017657	VANDF
4020828	VANDF
C0057610	UMLSCUI
CHEBI:27373	CHEBI
CHEMBL1200979	ChEMBL_ID
DB09357	DRUGBANK_ID
131204	PUBCHEM_CID
C007288	MESH_SUPPLEMENTAL_RECORD_UI
1023	INN_ID
1O6C93RI7Z	UNII
1536	MMSL
4558	MMSL
d01001	MMSL
001696	NDDF
126226000	SNOMEDCT_US
404842009	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
B-PLEX 100	HUMAN PRESCRIPTION DRUG LABEL	5	30727-300	INJECTION, SOLUTION	2 mg	INTRAMUSCULAR	unapproved drug other	10 sections
HASOL Anagen Hair Tonic	HUMAN OTC DRUG LABEL	3	51270-122	LIQUID	0.00 1	TOPICAL	unapproved drug other	8 sections
HASOL Anagen Scalp	HUMAN OTC DRUG LABEL	3	51270-123	SHAMPOO	0.00 1	TOPICAL	unapproved drug other	8 sections
HASOL Anti Hair Loss	HUMAN OTC DRUG LABEL	3	51270-124	SHAMPOO	0.00 1	TOPICAL	unapproved drug other	8 sections
HASOL Vital For Hair-Loss Tonic	HUMAN OTC DRUG LABEL	3	51270-125	LIQUID	0.00 1	TOPICAL	unapproved drug other	8 sections
PEDIATRIC INFUVITE MULTIPLE VITAMINS FOR INFUSION	HUMAN PRESCRIPTION DRUG LABEL	13	54643-5646	INJECTION, SOLUTION	5 mg	INTRAVENOUS	NDA	19 sections
PEDIATRIC INFUVITE MULTIPLE VITAMINS FOR INFUSION	HUMAN PRESCRIPTION DRUG LABEL	13	54643-5646	INJECTION, SOLUTION	5 mg	INTRAVENOUS	NDA	19 sections
Adult Infuvite Multiple Vitamins for Infusion	HUMAN PRESCRIPTION DRUG LABEL	13	54643-5649	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	17 sections
Adult Infuvite Multiple Vitamins for Infusion	HUMAN PRESCRIPTION DRUG LABEL	13	54643-5649	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	17 sections
Adult Infuvite Multiple Vitamins for Infusion	HUMAN PRESCRIPTION DRUG LABEL	13	54643-5649	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	17 sections
Infuvite Adult Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-5650	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Infuvite Adult Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-5650	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-7862	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-7862	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-7874	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-7874	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Pediatric Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-7886	INJECTION, SOLUTION	5 mg	INTRAVENOUS	NDA	19 sections
Pediatric Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-7886	INJECTION, SOLUTION	5 mg	INTRAVENOUS	NDA	19 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-9007	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-9007	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-9015	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-9015	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Pediatric Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-9023	INJECTION, SOLUTION	5 mg	INTRAVENOUS	NDA	19 sections
Pediatric Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-9023	INJECTION, SOLUTION	5 mg	INTRAVENOUS	NDA	19 sections
Vitamin B Complex	HUMAN PRESCRIPTION DRUG LABEL	5	67457-146	INJECTION	2 mg	INTRAVENOUS	Unapproved drug other	9 sections
NDM SCALP	HUMAN OTC DRUG LABEL	4	69288-001	SHAMPOO	1.40 g	TOPICAL	unapproved drug other	11 sections
YOZUM WELL BEING HAIR COLOR	HUMAN OTC DRUG LABEL	1	69525-2001	LIQUID	0.20 g	TOPICAL	OTC monograph not final	7 sections
Notamo Hair Tonic	HUMAN OTC DRUG LABEL	2	69709-102	LIQUID	0.20 1	TOPICAL	unapproved drug other	8 sections
Vitamin B Complex	HUMAN PRESCRIPTION DRUG LABEL	5	69877-026	INJECTION, SOLUTION	2 mg	INTRAMUSCULAR	unapproved drug other	10 sections
B-Combo	HUMAN PRESCRIPTION DRUG LABEL	6	70104-110	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	1 sections