dexpanthenol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	838	81-13-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: dexpanthenol (+)-panthenol bepanthen D-Panthenol	The alcohol of pantothenic acid Molecular weight: 205.25 Formula: C9H19NO4 CLOGP: -1.65 LIPINSKI: 0 HAC: 5 HDO: 4 TPSA: 89.79 ALOGS: -0.23 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

dexpanthenol
(+)-panthenol
bepanthen
D-Panthenol

The alcohol of pantothenic acid

Molecular weight: 205.25
Formula: C9H19NO4
CLOGP: -1.65
LIPINSKI: 0
HAC: 5
HDO: 4
TPSA: 89.79
ALOGS: -0.23
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Feb. 20, 1953	FDA	HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pneumonia aspiration	187.35	18.01	76	4224	32335	56255432
Gastrooesophageal reflux disease	139.86	18.01	84	4216	83173	56204594
Coma	129.04	18.01	71	4229	59584	56228183
Somnolence	81.63	18.01	80	4220	163333	56124434
Intestinal haemorrhage	37.61	18.01	13	4287	3533	56284234
Pulmonary vein occlusion	33.38	18.01	6	4294	105	56287662
Underdose	32.28	18.01	21	4279	23736	56264031
Optic nerve disorder	27.16	18.01	7	4293	695	56287072
Toxic epidermal necrolysis	26.36	18.01	18	4282	22024	56265743
Anterior segment ischaemia	23.16	18.01	4	4296	55	56287712
Tumour pain	22.94	18.01	7	4293	1284	56286483
Hepatic cirrhosis	22.25	18.01	16	4284	21247	56266520
Incorrect route of product administration	19.95	18.01	15	4285	21314	56266453
Neuropathy peripheral	18.10	18.01	30	4270	102863	56184904

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile bone marrow aplasia	43.07	19.81	17	2058	7829	31687440
Generalised oedema	39.96	19.81	18	2057	11483	31683786
Face oedema	38.11	19.81	17	2058	10599	31684670
General physical health deterioration	25.33	19.81	34	2041	113401	31581868
Dysuria	24.93	19.81	17	2058	24277	31670992
Anaemia	23.02	19.81	46	2029	213476	31481793

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pneumonia aspiration	90.67	15.99	59	5762	62230	70860393
Gastrooesophageal reflux disease	90.09	15.99	68	5753	90771	70831852
Coma	58.09	15.99	53	5768	91791	70830832
Somnolence	45.59	15.99	71	5750	215535	70707088
Pulmonary vein occlusion	31.69	15.99	6	5815	131	70922492
Intestinal haemorrhage	30.02	15.99	13	5808	6007	70916616
Underdose	26.89	15.99	21	5800	29362	70893261
Hepatic cirrhosis	23.96	15.99	20	5801	30711	70891912
Optic nerve disorder	23.38	15.99	7	5814	1120	70921503
Toxic epidermal necrolysis	23.37	15.99	22	5799	39535	70883088
Tumour pain	22.89	15.99	8	5813	2090	70920533
Anterior segment ischaemia	22.87	15.99	4	5817	55	70922568
Febrile bone marrow aplasia	21.55	15.99	13	5808	11978	70910645
Metastases to meninges	19.76	15.99	8	5813	3128	70919495
Stevens-Johnson syndrome	19.38	15.99	19	5802	35888	70886735
Incorrect route of product administration	18.13	15.99	16	5805	26476	70896147
Venous thrombosis limb	17.74	15.99	8	5813	4067	70918556
Generalised oedema	16.66	15.99	14	5807	21694	70900929

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A11HA30	ALIMENTARY TRACT AND METABOLISM VITAMINS OTHER PLAIN VITAMIN PREPARATIONS Other plain vitamin preparations
ATC	D03AX03	DERMATOLOGICALS PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS CICATRIZANTS Other cicatrizants
ATC	S01XA12	SENSORY ORGANS OPHTHALMOLOGICALS OTHER OPHTHALMOLOGICALS Other ophthalmologicals
CHEBI has role	CHEBI:38323	cholinergic drugs
CHEBI has role	CHEBI:50188	provitamins

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Eczema	indication	43116000
Toxicodendron radicans	indication	52352005
Paralytic ileus	indication	55525008	DOID:8442
Diaper rash	indication	91487003
Disorder of skin	indication	95320005	DOID:37
Contact dermatitis due to poison oak	indication	200824008
Gastroparesis	indication	235675006
Arthropod bite wound	indication	409985002
Paralytic Ileus Prevention	indication
Chafing of skin	off-label use	238474002
Eruption of skin	off-label use	271807003	DOID:0050486
Skin irritation	off-label use	367466007
Itching of skin	off-label use	418363000
Hemophilia	contraindication	90935002

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.71	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4020828	VUID
N0000146036	NUI
22701	RXNORM
4017657	VANDF
4020828	VANDF
C0057610	UMLSCUI
CHEBI:27373	CHEBI
CHEMBL1200979	ChEMBL_ID
DB09357	DRUGBANK_ID
131204	PUBCHEM_CID
1023	INN_ID
C007288	MESH_SUPPLEMENTAL_RECORD_UI
1O6C93RI7Z	UNII
1536	MMSL
4558	MMSL
d01001	MMSL
001696	NDDF
126226000	SNOMEDCT_US
404842009	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
B-PLEX 100	HUMAN PRESCRIPTION DRUG LABEL	5	30727-300	INJECTION, SOLUTION	2 mg	INTRAMUSCULAR	unapproved drug other	10 sections
HASOL Anagen Hair Tonic	HUMAN OTC DRUG LABEL	3	51270-122	LIQUID	0.00 1	TOPICAL	unapproved drug other	8 sections
HASOL Anagen Scalp	HUMAN OTC DRUG LABEL	3	51270-123	SHAMPOO	0.00 1	TOPICAL	unapproved drug other	8 sections
HASOL Anti Hair Loss	HUMAN OTC DRUG LABEL	3	51270-124	SHAMPOO	0.00 1	TOPICAL	unapproved drug other	8 sections
HASOL Vital For Hair-Loss Tonic	HUMAN OTC DRUG LABEL	3	51270-125	LIQUID	0.00 1	TOPICAL	unapproved drug other	8 sections
PEDIATRIC INFUVITE MULTIPLE VITAMINS FOR INFUSION	HUMAN PRESCRIPTION DRUG LABEL	13	54643-5646	INJECTION, SOLUTION	5 mg	INTRAVENOUS	NDA	19 sections
Adult Infuvite Multiple Vitamins for Infusion	HUMAN PRESCRIPTION DRUG LABEL	13	54643-5649	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	17 sections
Adult Infuvite Multiple Vitamins for Infusion	HUMAN PRESCRIPTION DRUG LABEL	13	54643-5649	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	17 sections
Infuvite Adult Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-5650	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-7862	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-7874	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Pediatric Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-7886	INJECTION, SOLUTION	5 mg	INTRAVENOUS	NDA	19 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-9007	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-9015	INJECTION, SOLUTION	15 mg	INTRAVENOUS	NDA	20 sections
Pediatric Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-9023	INJECTION, SOLUTION	5 mg	INTRAVENOUS	NDA	19 sections
Vitamin B Complex	HUMAN PRESCRIPTION DRUG LABEL	5	67457-146	INJECTION	2 mg	INTRAVENOUS	Unapproved drug other	9 sections
NDM SCALP	HUMAN OTC DRUG LABEL	4	69288-001	SHAMPOO	1.40 g	TOPICAL	unapproved drug other	11 sections
YOZUM WELL BEING HAIR COLOR	HUMAN OTC DRUG LABEL	1	69525-2001	LIQUID	0.20 g	TOPICAL	OTC monograph not final	7 sections
Notamo Hair Tonic	HUMAN OTC DRUG LABEL	2	69709-102	LIQUID	0.20 1	TOPICAL	unapproved drug other	8 sections
Vitamin B Complex	HUMAN PRESCRIPTION DRUG LABEL	5	69877-026	INJECTION, SOLUTION	2 mg	INTRAMUSCULAR	unapproved drug other	10 sections
B-Combo	HUMAN PRESCRIPTION DRUG LABEL	6	70104-110	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	1 sections
Lipovite	HUMAN PRESCRIPTION DRUG LABEL	13	70104-128	INJECTION	1 mg	INTRAMUSCULAR	unapproved drug other	1 sections
Therapytion Hair Tonic	HUMAN OTC DRUG LABEL	2	70477-101	LIQUID	0.00 1	TOPICAL	unapproved drug other	8 sections
VITAMIN B COMPLEX	HUMAN PRESCRIPTION DRUG LABEL	5	71414-225	INJECTION	2 mg	INTRAVENOUS	unapproved drug other	9 sections
Pelo Scalp Tonic Sheet	HUMAN OTC DRUG LABEL	3	73099-010	PATCH	0.07 g	TOPICAL	unapproved drug other	9 sections
BABYSONS	HUMAN OTC DRUG LABEL	1	73519-001	OINTMENT	50 mg	TOPICAL	OTC monograph not final	11 sections
Yakkongmo scalp deep cleansingshampoo	HUMAN OTC DRUG LABEL	4	73540-001	SHAMPOO	0.50 g	TOPICAL	unapproved drug other	7 sections
Yakkongmo hair serum tonic	HUMAN OTC DRUG LABEL	3	73540-002	LIQUID	0.20 g	TOPICAL	unapproved drug other	7 sections
Yakkongmo treatment	HUMAN OTC DRUG LABEL	3	73540-003	LIQUID	0.50 g	TOPICAL	unapproved drug other	7 sections
CRAZYSKIN BEERS	HUMAN OTC DRUG LABEL	3	73643-0001	SHAMPOO	0.20 g	TOPICAL	unapproved drug other	7 sections