dexpanthenol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
838 81-13-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexpanthenol
  • (+)-panthenol
  • bepanthen
  • D-Panthenol
The alcohol of pantothenic acid
  • Molecular weight: 205.25
  • Formula: C9H19NO4
  • CLOGP: -1.65
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 4
  • TPSA: 89.79
  • ALOGS: -0.23
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia aspiration 165.16 16.89 69 3881 30935 50570239
Gastrooesophageal reflux disease 113.85 16.89 72 3878 76356 50524818
Coma 111.66 16.89 64 3886 56815 50544359
Somnolence 70.79 16.89 73 3877 154912 50446262
Intestinal haemorrhage 38.73 16.89 13 3937 3167 50598007
Pulmonary vein occlusion 33.26 16.89 6 3944 105 50601069
Optic nerve disorder 27.04 16.89 7 3943 692 50600482
Toxic epidermal necrolysis 24.44 16.89 17 3933 20975 50580199
Tumour pain 23.13 16.89 7 3943 1223 50599951
Hepatic cirrhosis 19.91 16.89 14 3936 17563 50583611
Incorrect route of product administration 19.16 16.89 14 3936 18652 50582522
Venous thrombosis limb 17.94 16.89 7 3943 2615 50598559

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile bone marrow aplasia 43.69 20.94 17 1974 7334 29565202
Generalised oedema 39.99 20.94 18 1973 11147 29561389
Face oedema 38.18 20.94 17 1974 10266 29562270
Dysuria 25.72 20.94 17 1974 22423 29550113
Anaemia 24.09 20.94 46 1945 200905 29371631
General physical health deterioration 22.54 20.94 31 1960 102826 29469710

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia aspiration 72.96 17.78 51 5352 59220 64434109
Gastrooesophageal reflux disease 67.92 17.78 56 5347 83087 64410242
Coma 45.91 17.78 46 5357 87569 64405760
Somnolence 36.56 17.78 63 5340 203582 64289747
Pulmonary vein occlusion 31.57 17.78 6 5397 131 64493198
Intestinal haemorrhage 30.86 17.78 13 5390 5501 64487828
Optic nerve disorder 23.38 17.78 7 5396 1098 64492231
Tumour pain 23.37 17.78 8 5395 1925 64491404
Febrile bone marrow aplasia 22.07 17.78 13 5390 11242 64482087
Metastases to meninges 20.44 17.78 8 5395 2807 64490522
Hepatic cirrhosis 19.96 17.78 17 5386 26281 64467048
Breast cancer metastatic 18.73 17.78 10 5393 7159 64486170
Toxic epidermal necrolysis 18.50 17.78 19 5384 37147 64456182
Venous thrombosis limb 18.04 17.78 8 5395 3829 64489500
Stevens-Johnson syndrome 17.95 17.78 18 5385 34231 64459098

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA30 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
ATC D03AX03 DERMATOLOGICALS
PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
CICATRIZANTS
Other cicatrizants
ATC S01XA12 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
CHEBI has role CHEBI:38323 cholinergic drugs
CHEBI has role CHEBI:50188 provitamins

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Eczema indication 43116000
Toxicodendron radicans indication 52352005
Paralytic ileus indication 55525008 DOID:8442
Diaper rash indication 91487003
Disorder of skin indication 95320005 DOID:37
Contact dermatitis due to poison oak indication 200824008
Gastroparesis indication 235675006
Arthropod bite wound indication 409985002
Paralytic Ileus Prevention indication
Chafing of skin off-label use 238474002
Eruption of skin off-label use 271807003 DOID:0050486
Skin irritation off-label use 367466007
Itching of skin off-label use 418363000
Hemophilia contraindication 90935002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.71 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4020828 VUID
N0000146036 NUI
22701 RXNORM
4017657 VANDF
4020828 VANDF
C0057610 UMLSCUI
CHEBI:27373 CHEBI
CHEMBL1200979 ChEMBL_ID
DB09357 DRUGBANK_ID
131204 PUBCHEM_CID
1023 INN_ID
C007288 MESH_SUPPLEMENTAL_RECORD_UI
1O6C93RI7Z UNII
1536 MMSL
4558 MMSL
d01001 MMSL
001696 NDDF
126226000 SNOMEDCT_US
404842009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
B-PLEX 100 HUMAN PRESCRIPTION DRUG LABEL 5 30727-300 INJECTION, SOLUTION 2 mg INTRAMUSCULAR unapproved drug other 10 sections
HASOL Anagen Hair Tonic HUMAN OTC DRUG LABEL 3 51270-122 LIQUID 0.00 1 TOPICAL unapproved drug other 8 sections
HASOL Anagen Scalp HUMAN OTC DRUG LABEL 3 51270-123 SHAMPOO 0.00 1 TOPICAL unapproved drug other 8 sections
HASOL Anti Hair Loss HUMAN OTC DRUG LABEL 3 51270-124 SHAMPOO 0.00 1 TOPICAL unapproved drug other 8 sections
HASOL Vital For Hair-Loss Tonic HUMAN OTC DRUG LABEL 3 51270-125 LIQUID 0.00 1 TOPICAL unapproved drug other 8 sections
PEDIATRIC INFUVITE MULTIPLE VITAMINS FOR INFUSION HUMAN PRESCRIPTION DRUG LABEL 13 54643-5646 INJECTION, SOLUTION 5 mg INTRAVENOUS NDA 19 sections
Adult Infuvite Multiple Vitamins for Infusion HUMAN PRESCRIPTION DRUG LABEL 13 54643-5649 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 17 sections
Adult Infuvite Multiple Vitamins for Infusion HUMAN PRESCRIPTION DRUG LABEL 13 54643-5649 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 17 sections
Infuvite Adult Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-5650 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-7862 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-7874 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Pediatric Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-7886 INJECTION, SOLUTION 5 mg INTRAVENOUS NDA 19 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9007 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Adult Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9015 INJECTION, SOLUTION 15 mg INTRAVENOUS NDA 20 sections
Pediatric Infuvite Multiple Vitamins HUMAN PRESCRIPTION DRUG LABEL 13 54643-9023 INJECTION, SOLUTION 5 mg INTRAVENOUS NDA 19 sections
Vitamin B Complex HUMAN PRESCRIPTION DRUG LABEL 5 67457-146 INJECTION 2 mg INTRAVENOUS Unapproved drug other 9 sections
NDM SCALP HUMAN OTC DRUG LABEL 4 69288-001 SHAMPOO 1.40 g TOPICAL unapproved drug other 11 sections
YOZUM WELL BEING HAIR COLOR HUMAN OTC DRUG LABEL 1 69525-2001 LIQUID 0.20 g TOPICAL OTC monograph not final 7 sections
Notamo Hair Tonic HUMAN OTC DRUG LABEL 2 69709-102 LIQUID 0.20 1 TOPICAL unapproved drug other 8 sections
Vitamin B Complex HUMAN PRESCRIPTION DRUG LABEL 5 69877-026 INJECTION, SOLUTION 2 mg INTRAMUSCULAR unapproved drug other 10 sections
B-Combo HUMAN PRESCRIPTION DRUG LABEL 6 70104-110 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
Lipovite HUMAN PRESCRIPTION DRUG LABEL 13 70104-128 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
Therapytion Hair Tonic HUMAN OTC DRUG LABEL 2 70477-101 LIQUID 0.00 1 TOPICAL unapproved drug other 8 sections
VITAMIN B COMPLEX HUMAN PRESCRIPTION DRUG LABEL 5 71414-225 INJECTION 2 mg INTRAVENOUS unapproved drug other 9 sections
Pelo Scalp Tonic Sheet HUMAN OTC DRUG LABEL 3 73099-010 PATCH 0.07 g TOPICAL unapproved drug other 9 sections
BABYSONS HUMAN OTC DRUG LABEL 1 73519-001 OINTMENT 50 mg TOPICAL OTC monograph not final 11 sections
Yakkongmo scalp deep cleansingshampoo HUMAN OTC DRUG LABEL 4 73540-001 SHAMPOO 0.50 g TOPICAL unapproved drug other 7 sections
Yakkongmo hair serum tonic HUMAN OTC DRUG LABEL 3 73540-002 LIQUID 0.20 g TOPICAL unapproved drug other 7 sections
Yakkongmo treatment HUMAN OTC DRUG LABEL 3 73540-003 LIQUID 0.50 g TOPICAL unapproved drug other 7 sections
CRAZYSKIN BEERS HUMAN OTC DRUG LABEL 3 73643-0001 SHAMPOO 0.20 g TOPICAL unapproved drug other 7 sections