dexketoprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 833 22161-81-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexketoprofen trometamol
  • dexketoprofen
  • (S)-Ketoprofen
  • (+)-Ketoprofen
a water-soluble tromethamine salt of the racemic ketoprofen, rac(+-)-ketoprofen
  • Molecular weight: 254.29
  • Formula: C16H14O3
  • CLOGP: 2.76
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 54.37
  • ALOGS: -4.08
  • ROTB: 4

Drug dosage:

DoseUnitRoute
75 mg O
75 mg P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug interaction 55.10 42.85 42 1155 199579 50404348
Angioedema 49.62 42.85 22 1175 37654 50566273
Lichen planus 49.15 42.85 11 1186 1968 50601959

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperaesthesia 61.33 33.82 15 786 3454 29570272
Quality of life decreased 47.11 33.82 12 789 3250 29570476
Acute kidney injury 40.12 33.82 42 759 265225 29308501
Hyperkalaemia 34.16 33.82 21 780 61371 29512355

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 65.53 31.54 76 1999 449164 64047493
Angioedema 56.33 31.54 31 2044 61790 64434867
Drug interaction 52.24 31.54 61 2014 362022 64134635
Hyperbilirubinaemia 44.97 31.54 19 2056 21186 64475471
Hyperaesthesia 42.99 31.54 15 2060 9999 64486658
Hepatitis cholestatic 40.15 31.54 15 2060 12140 64484517
Quality of life decreased 38.60 31.54 13 2062 7793 64488864
Lichen planus 34.19 31.54 9 2066 2319 64494338
Bradyphrenia 32.50 31.54 12 2063 9394 64487263
Tubulointerstitial nephritis 32.32 31.54 17 2058 30892 64465765

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AE17 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
ATC M02AA27 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
ATC N02AJ14 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:50629 COX-2 inhibitor
CHEBI has role CHEBI:50630 COX-1 inhibitor

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.28 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 7.57 CHEMBL KEGG DRUG
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 8.72 CHEMBL KEGG DRUG

External reference:

IDSource
6KD9E78X68 UNII
D07269 KEGG_DRUG
233386 RXNORM
C0772505 UMLSCUI
CHEBI:76128 CHEBI
9KL PDB_CHEM_ID
CHEMBL75435 ChEMBL_ID
667550 PUBCHEM_CID
DB09214 DRUGBANK_ID
7120 INN_ID
C118296 MESH_SUPPLEMENTAL_RECORD_UI
007781 NDDF
007782 NDDF
329961001 SNOMEDCT_US
396018005 SNOMEDCT_US
427618005 SNOMEDCT_US

Pharmaceutical products:

None