dexketoprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-inflammatory agents, ibuprofen derivatives	833	22161-81-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

dexketoprofen trometamol
dexketoprofen
(S)-Ketoprofen
(+)-Ketoprofen

a water-soluble tromethamine salt of the racemic ketoprofen, rac(+-)-ketoprofen

Molecular weight: 254.29
Formula: C16H14O3
CLOGP: 2.76
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 54.37
ALOGS: -4.08
ROTB: 4

Drug dosage:

Dose	Unit	Route
75	mg	O
75	mg	P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug interaction	55.10	42.85	42	1155	199579	50404348
Angioedema	49.62	42.85	22	1175	37654	50566273
Lichen planus	49.15	42.85	11	1186	1968	50601959

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperaesthesia	61.33	33.82	15	786	3454	29570272
Quality of life decreased	47.11	33.82	12	789	3250	29570476
Acute kidney injury	40.12	33.82	42	759	265225	29308501
Hyperkalaemia	34.16	33.82	21	780	61371	29512355

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	65.53	31.54	76	1999	449164	64047493
Angioedema	56.33	31.54	31	2044	61790	64434867
Drug interaction	52.24	31.54	61	2014	362022	64134635
Hyperbilirubinaemia	44.97	31.54	19	2056	21186	64475471
Hyperaesthesia	42.99	31.54	15	2060	9999	64486658
Hepatitis cholestatic	40.15	31.54	15	2060	12140	64484517
Quality of life decreased	38.60	31.54	13	2062	7793	64488864
Lichen planus	34.19	31.54	9	2066	2319	64494338
Bradyphrenia	32.50	31.54	12	2063	9394	64487263
Tubulointerstitial nephritis	32.32	31.54	17	2058	30892	64465765

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M01AE17	MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Propionic acid derivatives
ATC	M02AA27	MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use
ATC	N02AJ14	NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with non-opioid analgesics
MeSH PA	D000700	Analgesics
MeSH PA	D018712	Analgesics, Non-Narcotic
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents
CHEBI has role	CHEBI:35475	non-steroidal anti-inflammatory agent
CHEBI has role	CHEBI:50629	COX-2 inhibitor
CHEBI has role	CHEBI:50630	COX-1 inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.28	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Prostaglandin G/H synthase 2	Enzyme	P35354	PGH2_HUMAN	INHIBITOR	IC50	7.57		CHEMBL	KEGG DRUG
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN	INHIBITOR	IC50	8.72		CHEMBL	KEGG DRUG

External reference:

ID	Source
6KD9E78X68	UNII
D07269	KEGG_DRUG
233386	RXNORM
C0772505	UMLSCUI
CHEBI:76128	CHEBI
9KL	PDB_CHEM_ID
CHEMBL75435	ChEMBL_ID
667550	PUBCHEM_CID
DB09214	DRUGBANK_ID
7120	INN_ID
C118296	MESH_SUPPLEMENTAL_RECORD_UI
007781	NDDF
007782	NDDF
329961001	SNOMEDCT_US
396018005	SNOMEDCT_US
427618005	SNOMEDCT_US

Pharmaceutical products:

None