dexetimide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
831 21888-98-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexetimide
  • dexbenzetimide
A muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide.
  • Molecular weight: 362.47
  • Formula: C23H26N2O2
  • CLOGP: 3.31
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 49.41
  • ALOGS: -4.89
  • ROTB: 4

Drug dosage:

DoseUnitRoute
0.50 mg O
0.13 mg P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N04AA08 NERVOUS SYSTEM
ANTI-PARKINSON DRUGS
ANTICHOLINERGIC AGENTS
Tertiary amines
MeSH PA D018726 Anti-Dyskinesia Agents
MeSH PA D000978 Antiparkinson Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018678 Cholinergic Agents
MeSH PA D018680 Cholinergic Antagonists
MeSH PA D018727 Muscarinic Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D010276 Parasympatholytics
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Neuroleptic-induced Parkinsonism indication 72820004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.81 acidic
pKa2 8.64 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M2 GPCR ANTAGONIST Ki 8.90 IUPHAR IUPHAR
Muscarinic acetylcholine receptor GPCR IC50 8.48 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR ANTAGONIST Ki 8.80 IUPHAR

External reference:

IDSource
D003909 MESH_DESCRIPTOR_UI
N0000167212 NUI
C0011785 UMLSCUI
D03711 KEGG_DRUG
43477QYX3D UNII
2726 INN_ID
007865 NDDF
3267 RXNORM
DB08997 DRUGBANK_ID
CHEBI:135531 CHEBI
354 IUPHAR_LIGAND_ID
CHEMBL1908364 ChEMBL_ID
30843 PUBCHEM_CID

Pharmaceutical products:

None