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dexetimide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 831 | 21888-98-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.50 | mg | O |
| 0.13 | mg | P |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,PDK1,PDK2,PDK4,PIK3CB,PRKDC | 15 | |||
| kinase-selectivity-class | AKT3,AXL,CDK9,ERBB2,FLT3,GRK2,SIK2 | 7 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N04AA08 | NERVOUS SYSTEM ANTI-PARKINSON DRUGS ANTICHOLINERGIC AGENTS Tertiary amines |
| MeSH PA | D000978 | Antiparkinson Agents |
| MeSH PA | D010276 | Parasympatholytics |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018678 | Cholinergic Agents |
| MeSH PA | D018680 | Cholinergic Antagonists |
| MeSH PA | D018726 | Anti-Dyskinesia Agents |
| MeSH PA | D018727 | Muscarinic Antagonists |
| CHEBI has role | CHEBI:48407 | antiparkinson drug |
Related Drugs by ATC class:
N04AA Tertiary amines 9 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Neuroleptic-induced Parkinsonism | indication | 72820004 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.81 | acidic |
| pKa2 | 8.64 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M2 | GPCR | ANTAGONIST | Ki | 8.90 | IUPHAR | IUPHAR | |||
| Muscarinic acetylcholine receptor M2 | GPCR | ANTAGONIST | Ki | 8.80 | IUPHAR | ||||
| Muscarinic acetylcholine receptor | GPCR | IC50 | 8.48 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000167212 | NUI |
| D03711 | KEGG_DRUG |
| 3267 | RXNORM |
| C0011785 | UMLSCUI |
| CHEBI:135531 | CHEBI |
| CHEMBL1908364 | ChEMBL_ID |
| DB08997 | DRUGBANK_ID |
| D003909 | MESH_DESCRIPTOR_UI |
| 30843 | PUBCHEM_CID |
| 354 | IUPHAR_LIGAND_ID |
| 2726 | INN_ID |
| 43477QYX3D | UNII |
| 007865 | NDDF |
Pharmaceutical products:
None