tropatepine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
atropine derivatives 2772 27574-24-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tropatepine
  • tropatepine hydrochloride
  • lepticur
  • Molecular weight: 333.49
  • Formula: C22H23NS
  • CLOGP: 5.05
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 0
  • TPSA: 3.24
  • ALOGS: -5.59
  • ROTB: 0

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 11.85 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.98 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 29.80 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MET,NTRK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,STK33,TEK,TGFBR1,TTK 34
kinase-selectivity-class AXL,EIF2AK3 2
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Coma 189.98 52.31 73 2516 72559 90553299
Poisoning deliberate 161.04 52.31 45 2544 16441 90609417
Wrong patient received product 130.21 52.31 28 2561 3449 90622409
Somnolence 92.03 52.31 63 2526 209021 90416837
Drug interaction 87.00 52.31 68 2521 276385 90349473
Faecaloma 77.36 52.31 23 2566 10408 90615450
Confusional state 76.72 52.31 73 2516 386132 90239726
Colitis ischaemic 73.54 52.31 23 2566 12323 90613535
Hepatocellular injury 71.58 52.31 28 2561 28930 90596928
Pneumonia aspiration 68.67 52.31 30 2559 40910 90584948
Intestinal obstruction 68.15 52.31 29 2560 37102 90588756
Livedo reticularis 65.54 52.31 16 2573 3443 90622415
Neuroleptic malignant syndrome 65.03 52.31 22 2567 15074 90610784
Suicide attempt 64.95 52.31 35 2554 75364 90550494
Drug reaction with eosinophilia and systemic symptoms 64.22 52.31 29 2560 42729 90583129
Extrapyramidal disorder 59.53 52.31 21 2568 16282 90609576
Axonal neuropathy 58.27 52.31 12 2577 1197 90624661
Housebound 55.42 52.31 9 2580 237 90625621

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intestinal obstruction 197.85 43.88 77 3465 27081 42590712
Coma 189.14 43.88 91 3451 53463 42564330
Somnolence 147.10 43.88 109 3433 140996 42476797
Extrapyramidal disorder 113.97 43.88 45 3497 16367 42601426
Neuroleptic malignant syndrome 108.81 43.88 47 3495 21425 42596368
Necrotising colitis 89.66 43.88 21 3521 1290 42616503
Rhabdomyolysis 89.49 43.88 64 3478 77955 42539838
Pneumonia aspiration 78.77 43.88 50 3492 50028 42567765
Product administration error 73.24 43.88 34 3508 18309 42599484
Mydriasis 71.36 43.88 27 3515 8743 42609050
Hepatocellular injury 70.77 43.88 36 3506 23642 42594151
Colitis ischaemic 68.91 43.88 25 3517 7201 42610592
Drug interaction 63.18 43.88 93 3449 266906 42350887
Large intestine perforation 62.16 43.88 25 3517 9511 42608282
Wrong patient received product 60.31 43.88 19 3523 3564 42614229
Hyperthermia 58.70 43.88 26 3516 12548 42605245
Wrong patient 58.58 43.88 13 3529 626 42617167
Urinary retention 56.21 43.88 38 3504 42176 42575617
Poisoning deliberate 53.98 43.88 23 3519 10111 42607682
Faecal vomiting 52.17 43.88 12 3530 680 42617113
Intestinal pseudo-obstruction 50.96 43.88 15 3527 2240 42615553
Faecaloma 49.90 43.88 19 3523 6251 42611542
Choking 49.82 43.88 19 3523 6279 42611514
Psychomotor skills impaired 49.59 43.88 18 3524 5186 42612607
Subileus 48.35 43.88 16 3526 3505 42614288
Hepatic cytolysis 45.16 43.88 28 3514 26816 42590977

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Coma 366.33 42.77 161 5856 117708 110465574
Intestinal obstruction 279.40 42.77 106 5911 53121 110530161
Somnolence 236.16 42.77 165 5852 297284 110285998
Poisoning deliberate 196.28 42.77 68 5949 26263 110557019
Neuroleptic malignant syndrome 182.82 42.77 69 5948 33990 110549292
Extrapyramidal disorder 182.64 42.77 66 5951 28801 110554481
Wrong patient received product 182.11 42.77 47 5970 6627 110576655
Pneumonia aspiration 156.57 42.77 80 5937 81153 110502129
Drug interaction 152.13 42.77 160 5857 500023 110083259
Rhabdomyolysis 145.10 42.77 87 5930 120314 110462968
Colitis ischaemic 140.64 42.77 48 5969 17702 110565580
Hepatocellular injury 137.22 42.77 63 5954 50579 110532703
Faecaloma 124.73 42.77 42 5975 14866 110568416
Confusional state 108.17 42.77 130 5887 468550 110114732
Urinary retention 104.24 42.77 58 5959 69625 110513657
Necrotising colitis 103.15 42.77 23 5994 1742 110581540
Hyperthermia 99.46 42.77 39 5978 21233 110562049
Intestinal pseudo-obstruction 93.32 42.77 24 5993 3332 110579950
Wrong patient 90.16 42.77 20 5997 1479 110581803
Cardio-respiratory arrest 79.49 42.77 59 5958 115777 110467505
Mydriasis 77.51 42.77 33 5984 22124 110561158
Distal intestinal obstruction syndrome 74.62 42.77 16 6001 1009 110582273
Behaviour disorder 72.16 42.77 25 5992 9622 110573660
Choking 68.16 42.77 27 5990 15083 110568199
Product administration error 66.86 42.77 35 5982 37182 110546100
Subileus 65.35 42.77 21 5996 6416 110576866
Faecal vomiting 62.67 42.77 15 6002 1551 110581731
Septic shock 59.76 42.77 57 5960 157471 110425811
Psychomotor skills impaired 59.47 42.77 20 5997 7038 110576244
Large intestine perforation 58.93 42.77 25 5992 16604 110566678
Hyperthermia malignant 57.76 42.77 17 6000 3883 110579399
Suicide attempt 56.42 42.77 46 5971 103348 110479934
Altered state of consciousness 50.26 42.77 34 5983 57592 110525690
Livedo reticularis 47.97 42.77 16 6001 5490 110577792
Drug abuse 47.07 42.77 53 5964 177358 110405924
Pulmonary embolism 46.85 42.77 58 5959 214416 110368866
Hypotension 45.84 42.77 93 5924 523756 110059526
Hepatic cytolysis 44.51 42.77 31 5986 55022 110528260
Housebound 43.94 42.77 9 6008 454 110582828
Anticholinergic syndrome 43.60 42.77 14 6003 4266 110579016

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N04AA12 NERVOUS SYSTEM
ANTI-PARKINSON DRUGS
ANTICHOLINERGIC AGENTS
Tertiary amines
CHEBI has role CHEBI:48407 antiparkinson drug

Related Drugs by ATC class:

N04AA Tertiary amines 9 drugs
biperidenbornaprinedexetimidemazaticolmetixenephenglutarimideprocyclidineprofenaminetrihexyphenidyl

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.1 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07303 KEGG_DRUG
C0077388 UMLSCUI
CHEBI:135419 CHEBI
CHEMBL2107294 ChEMBL_ID
DB13252 DRUGBANK_ID
C013322 MESH_SUPPLEMENTAL_RECORD_UI
3034047 PUBCHEM_CID
3250 INN_ID
C27HY5RFU5 UNII
236190 RXNORM
005365 NDDF
005366 NDDF
734969000 SNOMEDCT_US
734970004 SNOMEDCT_US
27574-25-0 SECONDARY_CAS_RN

Pharmaceutical products:

None