dexbrompheniramine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
830 132-21-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexbrompheniramine
  • d-Brompheniramine
  • (+)-Brompheniramine
  • dexbrompheniramine maleate
  • Molecular weight: 319.25
  • Formula: C16H19BrN2
  • CLOGP: 3.30
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 16.13
  • ALOGS: -4.40
  • ROTB: 5

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 18, 1963 FDA SCHERING PLOUGH

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R06AB06 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Substituted alkylamines
ATC R06AB56 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Substituted alkylamines
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D018377 Neurotransmitter Agents
CHEBI has role CHEBI:37955 H1 receptor antagonists
CHEBI has role CHEBI:50857 anti-allergic drugs

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Dermatographic urticaria indication 7632005 DOID:743
Vasomotor rhinitis indication 8229003 DOID:4730
Allergic rhinitis indication 61582004
Urticaria indication 126485001
Influenza-like symptoms indication 315642008
Seasonal allergic rhinitis indication 367498001
Itching of skin indication 418363000
Allergic conjunctivitis indication 473460002 DOID:11204
Ocular hypertension contraindication 4210003 DOID:9282
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Peptic ulcer contraindication 13200003 DOID:750
Asthenia contraindication 13791008
Constipation contraindication 14760008 DOID:2089
Mood swings contraindication 18963009
Myocardial infarction contraindication 22298006 DOID:5844
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Hypercapnia contraindication 29596007
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Hypothyroidism contraindication 40930008 DOID:1459
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Acidosis contraindication 51387008
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Hepatic failure contraindication 59927004
Ulcerative colitis contraindication 64766004 DOID:8577
Arterial thrombosis contraindication 65198009
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Poisoning by acetaminophen contraindication 70273001
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Urethral stricture contraindication 76618002
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Cor pulmonale contraindication 83291003 DOID:8515
Pulmonary emphysema contraindication 87433001
Kidney disease contraindication 90708001 DOID:557
Acute abdominal pain contraindication 116290004
Neoplasm of brain contraindication 126952004 DOID:1319
Seizure disorder contraindication 128613002
Drug-induced psychosis contraindication 191483003 DOID:1742
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Exacerbation of asthma contraindication 281239006
Lesion of brain contraindication 301766008
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Disorder of coronary artery contraindication 414024009
Central nervous system depression contraindication 418072004
Dysfunction of sphincter of Oddi contraindication 430887001
Hypertensive urgency contraindication 443482000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.47 Basic
pKa2 4.14 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST DRUGBANK CHEMBL

External reference:

IDSource
4019711 VUID
N0000147803 NUI
D03704 KEGG_DRUG
2391-03-9 SECONDARY_CAS_RN
22696 RXNORM
4018841 VANDF
4019711 VANDF
C0057605 UMLSCUI
CHEBI:59269 CHEBI
CHEMBL1201287 ChEMBL_ID
DB00405 DRUGBANK_ID
CHEMBL1200638 ChEMBL_ID
C015121 MESH_SUPPLEMENTAL_RECORD_UI
16960 PUBCHEM_CID
7588 IUPHAR_LIGAND_ID
907 INN_ID
75T64B71RP UNII
4555 MMSL
d03750 MMSL
003411 NDDF
004436 NDDF
387090008 SNOMEDCT_US
387429005 SNOMEDCT_US
75429004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Dexbrompherniramine Maleate and Pseudoephedrine Sulfate6mg/120mg HUMAN OTC DRUG LABEL 2 10702-005 TABLET, EXTENDED RELEASE 6 mg ORAL ANDA 13 sections
Chlo Tuss HUMAN OTC DRUG LABEL 3 12830-762 LIQUID 1 mg ORAL OTC monograph final 16 sections
M-ENDDMX HUMAN OTC DRUG LABEL 3 12830-816 LIQUID 0.67 mg ORAL OTC monograph final 16 sections
Chlo Hist HUMAN OTC DRUG LABEL 2 12830-864 LIQUID 1 mg ORAL OTC monograph final 15 sections
PediaVent HUMAN OTC DRUG LABEL 1 15370-110 SYRUP 2 mg ORAL OTC MONOGRAPH FINAL 15 sections
PediaVent HUMAN OTC DRUG LABEL 1 15370-112 TABLET, CHEWABLE 1 mg ORAL OTC MONOGRAPH FINAL 15 sections
G-Con-X HUMAN OTC DRUG LABEL 2 43913-405 LIQUID 1 mg ORAL OTC MONOGRAPH FINAL 15 sections
BionatussDXP HUMAN OTC DRUG LABEL 3 45737-210 LIQUID 2 mg ORAL OTC monograph final 10 sections
BIO-CNEX HUMAN OTC DRUG LABEL 2 45737-239 LIQUID 1 mg ORAL OTC monograph final 9 sections
Biogesic HUMAN OTC DRUG LABEL 2 45737-610 TABLET 1 mg ORAL OTC monograph not final 9 sections
Chlo Hist HUMAN OTC DRUG LABEL 2 50090-3998 LIQUID 1 mg ORAL OTC monograph final 15 sections
Polytussin DM HUMAN OTC DRUG LABEL 3 50991-121 LIQUID 2 mg ORAL OTC monograph final 16 sections
ALA-HIST IR HUMAN OTC DRUG LABEL 1 50991-783 TABLET 2 mg ORAL OTC monograph final 13 sections
Alahist CF HUMAN OTC DRUG LABEL 3 50991-784 TABLET 2 g ORAL OTC monograph final 10 sections
Alahist PE HUMAN OTC DRUG LABEL 2 50991-788 TABLET 2 mg ORAL OTC monograph final 15 sections
ALAHISTDM HUMAN OTC DRUG LABEL 3 50991-826 LIQUID 2 mg ORAL OTC monograph final 16 sections
SUPRESS A HUMAN OTC DRUG LABEL 3 52083-057 SYRUP 1 mg ORAL OTC monograph final 12 sections
Dologen HUMAN OTC DRUG LABEL 2 52083-481 TABLET 2 mg ORAL OTC monograph final 10 sections
Dologen 325 HUMAN OTC DRUG LABEL 2 52083-482 TABLET 1 mg ORAL OTC monograph final 10 sections
G-Dologen HUMAN OTC DRUG LABEL 2 52083-681 TABLET 2 mg ORAL OTC monograph final 10 sections
DologesicNF HUMAN OTC DRUG LABEL 2 54859-001 TABLET 1 mg ORAL OTC monograph not final 9 sections
DologesicDF HUMAN OTC DRUG LABEL 2 54859-010 TABLET 1 mg ORAL OTC monograph not final 10 sections
Conex HUMAN OTC DRUG LABEL 2 54859-702 TABLET 2 mg ORAL OTC monograph final 11 sections
Conex HUMAN OTC DRUG LABEL 2 54859-802 LIQUID 1 mg ORAL OTC monograph final 11 sections
ACTICON HUMAN OTC DRUG LABEL 2 63102-105 LIQUID 1 mg ORAL OTC monograph final 10 sections
ACTICON HUMAN OTC DRUG LABEL 2 63102-108 SOLUTION 2 mg ORAL OTC monograph final 10 sections
ACTICON HUMAN OTC DRUG LABEL 2 63102-401 TABLET 2 mg ORAL OTC monograph final 11 sections
ACTIDOGESIC HUMAN OTC DRUG LABEL 2 63102-402 TABLET 1 mg ORAL OTC monograph final 13 sections
ACTIDOGESIC DF HUMAN OTC DRUG LABEL 2 63102-403 TABLET 1 mg ORAL OTC monograph final 10 sections
Dexbrompheniramine Maleate and Phenylephrine Hydrochloride HUMAN OTC DRUG LABEL 2 69367-197 TABLET 2 mg ORAL OTC MONOGRAPH FINAL 17 sections