dexamethasone palmitate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| prednisone and prednisolone derivatives | 828 | 14899-36-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
a liposteroid for treatment of hemophagocytic lymphohistiocytosis
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.08 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D000932 | Antiemetics |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D018931 | Antineoplastic Agents, Hormonal |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D005765 | Gastrointestinal Agents |
| MeSH PA | D005938 | Glucocorticoids |
| MeSH PA | D006728 | Hormones |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:35703 | Xenobiotic |
| CHEBI has role | CHEBI:35705 | immunosuppressive agents |
| CHEBI has role | CHEBI:37962 | adrenergic agents |
| CHEBI has role | CHEBI:50919 | antiemetico |
| CHEBI has role | CHEBI:78298 | environmental contaminants |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.06 | acidic |
| pKa2 | 13.41 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | Ki | 8.26 | CHEMBL | |||||
| Mineralocorticoid receptor | Nuclear hormone receptor | IC50 | 7.48 | CHEMBL | |||||
| Androgen receptor | Nuclear hormone receptor | Ki | 5.85 | CHEMBL | |||||
| Progesterone receptor | Nuclear hormone receptor | Ki | 6.25 | CHEMBL | |||||
| Androgen receptor | Transcription factor | IC50 | 4.09 | CHEMBL | |||||
| Fatty acid-binding protein, liver | Unclassified | Ki | 4.66 | CHEMBL | |||||
| Progesterone receptor | Transcription factor | IC50 | 4.63 | CHEMBL | |||||
| Glucocorticoid receptor | Transcription factor | IC50 | 7.66 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01615 | KEGG_DRUG |
| 3264 | RXNORM |
| 4017922 | VANDF |
| C5222049 | UMLSCUI |
| CHEBI:31471 | CHEBI |
| CHEBI:41879 | CHEBI |
| DEX | PDB_CHEM_ID |
| CHEMBL384467 | ChEMBL_ID |
| C035081 | MESH_SUPPLEMENTAL_RECORD_UI |
| 601XWN7060 | UNII |
| 63044 | PUBCHEM_CID |
| DB01234 | DRUGBANK_ID |
| 4552 | MMSL |
| 6848 | MMSL |
| d00206 | MMSL |
| 002174 | NDDF |
| 018179 | NDDF |
| 372584003 | SNOMEDCT_US |
| 7561000 | SNOMEDCT_US |
| C0011777 | UMLSCUI |
| 816 | INN_ID |
| 5743 | PUBCHEM_CID |
| D003907 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
None