dexamethasone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 824 50-02-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexamethasone
  • dexasone
  • dexmethsone
An anti-inflammatory 9-fluoro-glucocorticoid. The NIH COVID-19 Treatment Guidelines Panel recommends the use of dexamethasone in patients with COVID-19 who are receiving mechanical ventilation or in those who require supplemental oxygen but are not on me-chanical ventilation. It is not recommended the use of dexamethasone or other corticosteroids in nonhospitalized patients with mild to moderate COVID-19 or in hospitalized patients with COVID-19 who do not require supplemental oxygen.
  • Molecular weight: 392.47
  • Formula: C22H29FO5
  • CLOGP: 1.78
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.89
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 mg O
1.50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.08 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 2.60 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.33 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.94 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.32 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 25, 2021 PMDA NICHI - IKO PHARMACEUTICAL Co., Ltd.
Oct. 30, 1958 FDA
July 26, 2010 EMA AbbVie Deutschland GmbH & Co. KG

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 2646.05 10.38 1867 323768 34038 63129349
Neutropenia 2135.34 10.38 3474 322161 171531 62991856
Neuropathy peripheral 2047.03 10.38 2712 322923 110955 63052432
Febrile neutropenia 1748.64 10.38 2569 323066 115880 63047507
Thrombocytopenia 1671.05 10.38 2872 322763 148285 63015102
Disease progression 989.69 10.38 2039 323596 120719 63042668
Diarrhoea 948.56 10.38 6585 319050 708781 62454606
Rheumatoid arthritis 808.43 10.38 160 325475 253659 62909728
Death 737.43 10.38 3826 321809 370555 62792832
Pneumonia 677.29 10.38 4328 321307 452439 62710948
Platelet count decreased 669.99 10.38 1690 323945 114432 63048955
Systemic lupus erythematosus 662.39 10.38 133 325502 208785 62954602
Completed suicide 651.96 10.38 21 325614 145652 63017735
Constipation 624.35 10.38 2544 323091 222399 62940988
Pemphigus 594.98 10.38 111 325524 183615 62979772
Plasma cell myeloma recurrent 590.01 10.38 301 325334 2912 63160475
Contraindicated product administered 570.28 10.38 202 325433 217446 62945941
Pain 557.72 10.38 1944 323691 738684 62424703
Neutrophil count decreased 544.08 10.38 1011 324624 55395 63107992
Drug ineffective 530.84 10.38 3172 322463 1041593 62121794
Pancytopenia 528.25 10.38 1381 324254 95552 63067835
White blood cell count decreased 528.10 10.38 1742 323893 137362 63026025
Arthralgia 518.03 10.38 1370 324265 568340 62595047
Anaemia 512.81 10.38 2904 322731 290526 62872861
Hand deformity 491.98 10.38 108 325527 159349 63004038
Therapeutic product effect decreased 488.05 10.38 190 325445 192997 62970390
Sepsis 480.69 10.38 1801 323834 151322 63012065
Arthropathy 469.38 10.38 314 325321 234478 62928909
Full blood count decreased 466.03 10.38 620 325015 25404 63137983
Glossodynia 433.85 10.38 187 325448 178689 62984698
Synovitis 430.69 10.38 210 325425 186708 62976679
Mucosal inflammation 428.81 10.38 822 324813 46106 63117281
Abdominal discomfort 423.13 10.38 619 325016 320266 62843121
Drug hypersensitivity 413.89 10.38 595 325040 310092 62853295
Leukopenia 400.57 10.38 1081 324554 76209 63087178
Joint swelling 391.43 10.38 675 324960 326991 62836396
Off label use 389.29 10.38 5214 320421 669248 62494139
Injection site pain 374.77 10.38 101 325534 129699 63033688
Cytopenia 365.83 10.38 370 325265 11231 63152156
Plasmacytoma 364.66 10.38 203 325432 2376 63161011
Deep vein thrombosis 360.44 10.38 1096 324539 82704 63080683
Anti-cyclic citrullinated peptide antibody positive 349.82 10.38 83 325552 116129 63047258
Swelling 348.63 10.38 546 325089 274832 62888555
Pericarditis 346.37 10.38 121 325514 131458 63031929
Condition aggravated 336.94 10.38 1005 324630 401212 62762175
Thrombosis 332.81 10.38 903 324732 63852 63099535
Wound 322.56 10.38 221 325414 163042 63000345
Musculoskeletal stiffness 315.59 10.38 289 325346 184329 62979058
Neutropenic sepsis 311.93 10.38 403 325232 16035 63147352
Intentional overdose 310.70 10.38 17 325618 74135 63089252
Septic shock 294.55 10.38 880 324755 65749 63097638
Psoriasis 286.83 10.38 50 325585 86907 63076480
Hepatic enzyme increased 280.69 10.38 376 325259 201952 62961435
Polyneuropathy 278.92 10.38 359 325276 14230 63149157
Unevaluable event 270.49 10.38 723 324912 50663 63112724
Pulmonary embolism 266.09 10.38 1245 324390 115439 63047948
Treatment failure 265.00 10.38 381 325254 198662 62964725
Malignant neoplasm progression 261.66 10.38 971 324664 81150 63082237
Discomfort 256.41 10.38 288 325347 167086 62996301
Psoriatic arthropathy 248.08 10.38 80 325555 91440 63071947
Tumour lysis syndrome 246.34 10.38 266 325369 8724 63154663
Overdose 241.99 10.38 145 325490 114933 63048454
Laboratory test abnormal 239.18 10.38 466 325169 26446 63136941
Headache 238.61 10.38 2090 323545 631151 62532236
Drug abuse 236.34 10.38 43 325592 72475 63090912
Drug intolerance 233.95 10.38 806 324829 307855 62855532
Rheumatoid factor positive 230.17 10.38 73 325562 84333 63079054
Posterior reversible encephalopathy syndrome 223.97 10.38 354 325281 16991 63146396
Peripheral sensory neuropathy 221.08 10.38 230 325405 7221 63156166
Febrile bone marrow aplasia 220.74 10.38 228 325407 7097 63156290
Helicobacter infection 218.55 10.38 101 325534 92684 63070703
Asthenia 217.14 10.38 2958 322677 380646 62782741
Therapy partial responder 209.62 10.38 266 325369 10392 63152995
Pyrexia 208.23 10.38 3478 322157 467000 62696387
Suicide attempt 207.65 10.38 32 325603 60886 63102501
Injection site erythema 203.05 10.38 86 325549 83088 63080299
Mobility decreased 197.24 10.38 198 325437 120961 63042426
Loss of personal independence in daily activities 195.70 10.38 129 325506 97161 63066226
Cytokine release syndrome 187.40 10.38 294 325341 14020 63149367
Bone marrow failure 179.97 10.38 437 325198 28853 63134534
Flushing 179.86 10.38 813 324822 74274 63089113
Plasma cell leukaemia 179.30 10.38 96 325539 1034 63162353
Light chain analysis increased 177.82 10.38 101 325534 1232 63162155
Irritable bowel syndrome 168.85 10.38 107 325528 82305 63081082
Haematotoxicity 168.78 10.38 224 325411 9152 63154235
Muscle injury 166.97 10.38 63 325572 65282 63098105
Duodenal ulcer perforation 166.96 10.38 122 325513 87087 63076300
Multiple sclerosis relapse 159.57 10.38 28 325607 48450 63114937
Injection site reaction 158.87 10.38 51 325584 58473 63104914
Dehydration 158.22 10.38 1469 324166 171885 62991502
Knee arthroplasty 156.73 10.38 42 325593 54164 63109223
Abortion spontaneous 155.91 10.38 27 325608 47168 63116219
Bone pain 154.32 10.38 622 325013 54019 63109368
Maternal exposure during pregnancy 153.18 10.38 595 325040 219467 62943920
Impaired healing 153.12 10.38 180 325455 102362 63061025
Therapeutic product effect incomplete 149.59 10.38 257 325378 124799 63038588
Osteoarthritis 149.31 10.38 161 325474 95182 63068205
Venoocclusive liver disease 148.41 10.38 152 325483 4683 63158704
Pneumocystis jirovecii pneumonia 145.59 10.38 289 325346 16625 63146762
COVID-19 pneumonia 144.90 10.38 261 325374 13948 63149439
Osteonecrosis 144.37 10.38 360 325275 24170 63139217
Fatigue 142.68 10.38 5732 319903 882296 62281091
Sinusitis 140.33 10.38 641 324994 226012 62937375
Diffuse large B-cell lymphoma recurrent 137.73 10.38 106 325529 2214 63161173
Endophthalmitis 136.62 10.38 127 325508 3465 63159922
Suicidal ideation 136.40 10.38 75 325560 62346 63101041
Injection site pruritus 136.15 10.38 32 325603 45084 63118303
Sleep disorder due to general medical condition, insomnia type 135.67 10.38 49 325586 52168 63111219
Alopecia 135.26 10.38 1095 324540 336441 62826946
Injection site swelling 133.55 10.38 39 325596 47533 63115854
Injection site bruising 132.00 10.38 27 325608 41883 63121504
Pneumonitis 131.55 10.38 439 325196 34783 63128604
Monoclonal immunoglobulin present 131.40 10.38 71 325564 780 63162607
Blister 130.89 10.38 295 325340 129519 63033868
Folliculitis 129.94 10.38 102 325533 70215 63093172
Haemophagocytic lymphohistiocytosis 126.44 10.38 209 325426 10418 63152969
Metastases to central nervous system 126.40 10.38 235 325400 12870 63150517
Migraine 125.78 10.38 210 325425 103136 63060251
Neurotoxicity 124.80 10.38 272 325363 16718 63146669
Hyperglycaemia 121.75 10.38 481 325154 41386 63122001
Hepatitis B reactivation 121.42 10.38 112 325523 3025 63160362
Multiple organ dysfunction syndrome 114.55 10.38 585 325050 56167 63107220
Arthritis 113.97 10.38 267 325368 115654 63047733
Plasma cell myeloma refractory 113.63 10.38 49 325586 310 63163077
Asthma 112.89 10.38 310 325325 127251 63036136
Decreased appetite 112.19 10.38 1860 323775 249192 62914195
Product use issue 111.60 10.38 668 324967 219852 62943535
Bronchopulmonary aspergillosis 111.15 10.38 176 325459 8459 63154928
Hip arthroplasty 110.43 10.38 53 325582 47593 63115794
Intentional self-injury 110.42 10.38 5 325630 25682 63137705
Myelodysplastic syndrome 108.34 10.38 255 325380 16499 63146888
Acute lymphocytic leukaemia recurrent 107.80 10.38 91 325544 2178 63161209
Depression 107.64 10.38 580 325055 195912 62967475
Hypokalaemia 105.63 10.38 901 324734 102903 63060484
Stress 105.62 10.38 113 325522 67054 63096333
Anaphylactic shock 103.31 10.38 311 325324 23322 63140065
Pain in extremity 103.01 10.38 1145 324490 330341 62833046
Intentional product misuse 102.05 10.38 97 325538 60820 63102567
Fibromyalgia 102.00 10.38 159 325476 80261 63083126
Wrong technique in product usage process 101.28 10.38 102 325533 62238 63101149
Respiratory failure 99.41 10.38 876 324759 100982 63062405
Osteolysis 98.63 10.38 96 325539 2778 63160609
Inappropriate schedule of product administration 97.05 10.38 246 325389 103719 63059668
Ill-defined disorder 96.84 10.38 169 325466 81586 63081801
Lymphopenia 96.54 10.38 258 325377 18069 63145318
Dysgeusia 96.02 10.38 484 325151 46226 63117161
Mucormycosis 94.99 10.38 94 325541 2777 63160610
Injury 94.64 10.38 143 325492 73104 63090283
Hospitalisation 91.86 10.38 186 325449 84895 63078492
Cardiac amyloidosis 90.48 10.38 55 325580 767 63162620
Blood potassium decreased 89.60 10.38 440 325195 41586 63121801
Corneal oedema 88.16 10.38 68 325567 1425 63161962
Ageusia 86.66 10.38 207 325428 13521 63149866
Ejection fraction decreased 84.86 10.38 280 325355 22052 63141335
Surgery 84.68 10.38 39 325596 35873 63127514
Drug withdrawal syndrome 84.65 10.38 18 325617 27176 63136211
Cytomegalovirus infection 83.50 10.38 267 325368 20685 63142702
Hypoxia 83.38 10.38 559 325076 59233 63104154
Corneal decompensation 82.08 10.38 24 325611 33 63163354
Nausea 82.04 10.38 5251 320384 849220 62314167
Acute lymphocytic leukaemia 80.70 10.38 81 325554 2435 63160952
Aspergillus infection 80.41 10.38 147 325488 7946 63155441
Systemic candida 78.55 10.38 90 325545 3155 63160232
Premature delivery 77.88 10.38 335 325300 29946 63133441
Blood pressure fluctuation 77.29 10.38 74 325561 46243 63117144
Back pain 76.57 10.38 1834 323801 262311 62901076
Type 2 diabetes mellitus 76.57 10.38 131 325504 63737 63099650
Clostridium difficile colitis 76.47 10.38 256 325379 20313 63143074
Sleep apnoea syndrome 76.25 10.38 27 325608 29106 63134281
Fall 74.97 10.38 1490 324145 390844 62772543
Incorrect dose administered 74.68 10.38 120 325515 59848 63103539
Haemoglobin decreased 74.45 10.38 1103 324532 144382 63019005
Myelosuppression 74.38 10.38 279 325356 23424 63139963
Foot deformity 74.31 10.38 25 325610 27828 63135559
Myocardial infarction 74.06 10.38 263 325372 99630 63063757
Blood pressure systolic increased 73.12 10.38 81 325554 47316 63116071
Bacteraemia 72.74 10.38 225 325410 17123 63146264
Pathological fracture 72.51 10.38 148 325487 8686 63154701
Drug interaction 71.28 10.38 791 324844 228340 62935047
Renal failure 71.16 10.38 919 324716 116733 63046654
Gait disturbance 71.08 10.38 599 325036 182579 62980808
Accidental exposure to product 70.70 10.38 26 325609 27379 63136008
Rhinovirus infection 70.68 10.38 101 325534 4428 63158959
Cytomegalovirus infection reactivation 70.29 10.38 94 325541 3869 63159518
Weight increased 69.85 10.38 930 324705 259862 62903525
Rhinocerebral mucormycosis 69.59 10.38 38 325597 427 63162960
Palmar-plantar erythrodysaesthesia syndrome 69.00 10.38 267 325368 22748 63140639
Febrile infection 68.99 10.38 60 325575 1497 63161890
Pneumonia influenzal 68.44 10.38 62 325573 1635 63161752
Red blood cell sedimentation rate increased 68.03 10.38 75 325560 43907 63119480
Neutrophil count abnormal 67.97 10.38 79 325556 2813 63160574
Hypoglycaemia 67.70 10.38 128 325507 59937 63103450
Strongyloidiasis 67.56 10.38 54 325581 1194 63162193
Hypertriglyceridaemia 66.42 10.38 117 325518 6142 63157245
Eastern Cooperative Oncology Group performance status worsened 65.21 10.38 53 325582 1201 63162186
Neoplasm progression 64.98 10.38 363 325272 36065 63127322
Impaired work ability 64.79 10.38 7 325628 17468 63145919
Pulmonary thrombosis 64.69 10.38 140 325495 8562 63154825
Hypercholesterolaemia 64.63 10.38 15 325620 21319 63142068
Vasogenic cerebral oedema 64.56 10.38 46 325589 850 63162537
Injection site haemorrhage 64.55 10.38 22 325613 24292 63139095
Coma 64.25 10.38 147 325488 64217 63099170
Bronchospasm 64.18 10.38 215 325420 17065 63146322
Red blood cell sedimentation rate abnormal 63.86 10.38 12 325623 19770 63143617
Joint range of motion decreased 63.84 10.38 44 325591 32384 63131003
Colitis ulcerative 63.62 10.38 27 325608 26064 63137323
Coronary artery disease 62.33 10.38 45 325590 32332 63131055
Osteoporosis 62.19 10.38 125 325510 57213 63106174
Erythema 61.91 10.38 1255 324380 174496 62988891
Immune effector cell-associated neurotoxicity syndrome 61.73 10.38 67 325568 2210 63161177
Respiratory syncytial virus infection 61.71 10.38 121 325514 6897 63156490
C-reactive protein abnormal 61.49 10.38 88 325547 46008 63117379
Sedation 61.33 10.38 65 325570 38744 63124643
Substance-induced psychotic disorder 61.09 10.38 62 325573 1889 63161498
Bone erosion 61.07 10.38 9 325626 17708 63145679
Rheumatic fever 60.84 10.38 79 325556 43032 63120355
Contusion 60.32 10.38 486 325149 149558 63013829
Large intestine perforation 60.27 10.38 134 325501 8348 63155039
Multiple sclerosis 59.78 10.38 25 325610 24347 63139040
Aplasia 59.28 10.38 90 325545 4169 63159218
Colitis 59.07 10.38 439 325196 48089 63115298
Product quality issue 59.03 10.38 58 325577 35807 63127580
Wheezing 58.70 10.38 271 325364 95324 63068063
Tenosynovitis 58.28 10.38 3 325632 13792 63149595
Escherichia bacteraemia 56.82 10.38 84 325551 3799 63159588
Pregnancy 56.77 10.38 63 325572 36773 63126614
Obesity 55.89 10.38 43 325592 29909 63133478
Blood cholesterol increased 55.73 10.38 270 325365 93762 63069625
Muscle spasticity 55.68 10.38 21 325614 21773 63141614
Candida infection 55.63 10.38 290 325345 28061 63135326
Blood pressure diastolic decreased 54.56 10.38 24 325611 22682 63140705
Protein total increased 54.12 10.38 69 325566 2708 63160679
Pneumonia fungal 54.09 10.38 99 325536 5356 63158031
Sleep disorder 53.86 10.38 225 325410 81341 63082046
Bone lesion 53.67 10.38 103 325532 5778 63157609
Weight fluctuation 53.51 10.38 140 325495 9679 63153708
Blood pressure diastolic abnormal 53.47 10.38 6 325629 14536 63148851
Coeliac disease 53.39 10.38 3 325632 12794 63150593
Computerised tomogram thorax abnormal 53.34 10.38 55 325580 1708 63161679
Carpal tunnel syndrome 53.28 10.38 20 325615 20797 63142590
Muscle spasms 52.03 10.38 1106 324529 155044 63008343
Joint stiffness 51.93 10.38 84 325551 41785 63121602
Injection site warmth 51.73 10.38 8 325627 15187 63148200
Neutropenic colitis 51.24 10.38 71 325564 3024 63160363
COVID-19 51.17 10.38 840 324795 112263 63051124
Nasopharyngitis 51.12 10.38 957 324678 253300 62910087
Injection site mass 51.08 10.38 16 325619 18640 63144747
Atrial fibrillation 50.85 10.38 861 324774 115775 63047612
Liver injury 50.64 10.38 151 325484 60369 63103018
Product complaint 50.51 10.38 4 325631 12805 63150582
Brain stem glioma 50.46 10.38 23 325612 169 63163218
Hypersensitivity 50.43 10.38 1130 324505 291555 62871832
Herpes simplex encephalitis 50.05 10.38 28 325607 331 63163056
Lupus-like syndrome 49.97 10.38 9 325626 15286 63148101
Swollen joint count increased 49.92 10.38 67 325568 35987 63127400
Taste disorder 49.87 10.38 169 325466 13493 63149894
Hypofibrinogenaemia 49.66 10.38 44 325591 1126 63162261
Laryngospasm 49.43 10.38 69 325566 2959 63160428
Therapeutic response shortened 48.94 10.38 3 325632 11885 63151502
Injection site urticaria 48.85 10.38 7 325628 14066 63149321
Dyspnoea 48.65 10.38 3979 321656 657334 62506053
Device issue 48.52 10.38 31 325604 23750 63139637
Brain abscess 48.35 10.38 57 325578 2061 63161326
Brain oedema 47.83 10.38 171 325464 14024 63149363
Hyperviscosity syndrome 47.66 10.38 22 325613 167 63163220
Cataract 47.29 10.38 474 325161 56579 63106808
Computerised tomogram thorax 46.76 10.38 29 325606 420 63162967
Pulmonary arterial hypertension 46.66 10.38 29 325606 22548 63140839
Nasal congestion 46.60 10.38 176 325459 65484 63097903
Peripheral motor neuropathy 46.51 10.38 50 325585 1631 63161756
Embolism 46.48 10.38 116 325519 7790 63155597
Sedation complication 45.45 10.38 8 325627 13814 63149573
Disseminated intravascular coagulation 45.38 10.38 206 325429 18845 63144542
Human chorionic gonadotropin increased 45.37 10.38 48 325587 1537 63161850
Vomiting 45.20 10.38 3392 322243 556225 62607162
Nephrolithiasis 45.12 10.38 92 325543 41892 63121495
Primary amyloidosis 44.89 10.38 15 325620 40 63163347
Drug ineffective for unapproved indication 44.83 10.38 314 325321 33749 63129638
Pneumonia pneumococcal 44.69 10.38 56 325579 2159 63161228
Product use in unapproved indication 44.39 10.38 1218 324417 177862 62985525
Influenza like illness 44.32 10.38 184 325451 66640 63096747
Therapy non-responder 44.25 10.38 589 325046 75312 63088075
International normalised ratio increased 43.97 10.38 109 325526 46316 63117071
Withdrawal syndrome 43.72 10.38 24 325611 19973 63143414
Cardiotoxicity 43.64 10.38 118 325517 8320 63155067
Injection site rash 43.46 10.38 21 325614 18788 63144599
Osteonecrosis of jaw 43.46 10.38 319 325316 34804 63128583
Blood pressure increased 43.32 10.38 578 325057 161484 63001903
Lacrimation increased 43.26 10.38 215 325420 20416 63142971
Chronic obstructive pulmonary disease 43.22 10.38 170 325465 62516 63100871
Palpitations 43.16 10.38 370 325265 112400 63050987
Dry skin 43.07 10.38 464 325171 56423 63106964
Macular degeneration 42.99 10.38 37 325598 24339 63139048
Eczema 42.72 10.38 62 325573 32229 63131158
Ileus 42.66 10.38 169 325466 14556 63148831
Joint effusion 42.66 10.38 17 325618 17043 63146344
Venous thrombosis 42.47 10.38 84 325551 4818 63158569
Sopor 42.41 10.38 31 325604 22133 63141254
Inflammation 42.21 10.38 248 325387 82025 63081362
Ankylosing spondylitis 42.07 10.38 3 325632 10471 63152916
Intestinal perforation 41.93 10.38 146 325489 11817 63151570
Lactic acidosis 41.92 10.38 83 325552 38204 63125183
Hypocalcaemia 41.54 10.38 292 325343 31421 63131966
Haemoglobin abnormal 41.47 10.38 85 325550 5003 63158384
Premature baby 41.31 10.38 213 325422 20522 63142865
Pleural effusion 40.96 10.38 689 324946 92521 63070866
Intraocular pressure increased 40.93 10.38 94 325541 5984 63157403
Breast cancer metastatic 40.69 10.38 145 325490 11873 63151514
Cytomegalovirus chorioretinitis 40.51 10.38 48 325587 1745 63161642
Vitreous haemorrhage 40.05 10.38 51 325584 1999 63161388
Musculoskeletal pain 39.36 10.38 294 325341 91983 63071404
Paraesthesia 39.29 10.38 1069 324566 155897 63007490
Crying 39.29 10.38 37 325598 23306 63140081
Full blood count increased 39.28 10.38 37 325598 1027 63162360
Rhabdomyolysis 38.71 10.38 107 325528 43844 63119543
Blood lactate dehydrogenase abnormal 38.50 10.38 24 325611 351 63163036
Hepatic cirrhosis 38.44 10.38 42 325593 24692 63138695
Neutropenic infection 38.42 10.38 41 325594 1326 63162061
Hypercalcaemia 38.40 10.38 263 325372 28059 63135328
Prescribed overdose 38.29 10.38 73 325562 34080 63129307
Exostosis 38.24 10.38 22 325613 17840 63145547
Aplastic anaemia 38.18 10.38 122 325513 9447 63153940
Blood lactate dehydrogenase increased 37.73 10.38 225 325410 22891 63140496
Procedural pain 37.72 10.38 33 325602 21536 63141851
Therapy interrupted 37.60 10.38 68 325567 32387 63131000
Labelled drug-drug interaction medication error 37.57 10.38 11 325624 13388 63149999
B precursor type acute leukaemia 37.55 10.38 20 325615 213 63163174
Treatment noncompliance 37.44 10.38 85 325550 37240 63126147
Respiratory distress 37.35 10.38 300 325335 33651 63129736
Amyloidosis 37.25 10.38 37 325598 1098 63162289
Product storage error 37.24 10.38 15 325620 14941 63148446
Clostridium difficile infection 37.16 10.38 272 325363 29650 63133737
Squamous cell carcinoma of skin 37.14 10.38 91 325544 6041 63157346
Body height decreased 37.08 10.38 125 325510 9953 63153434
Hypogammaglobulinaemia 36.95 10.38 100 325535 7055 63156332
Shock 36.78 10.38 226 325409 23237 63140150
Ulcer 36.67 10.38 48 325587 26059 63137328
Bursitis 36.64 10.38 85 325550 36956 63126431
Panniculitis 36.55 10.38 7 325628 11378 63152009
B-cell type acute leukaemia 36.53 10.38 19 325616 192 63163195
Parainfluenzae virus infection 36.47 10.38 52 325583 2275 63161112
Pneumatosis intestinalis 36.47 10.38 53 325582 2360 63161027
Breast cancer female 36.47 10.38 12 325623 13547 63149840
Acute respiratory distress syndrome 36.47 10.38 226 325409 23308 63140079
Human bocavirus infection 36.38 10.38 24 325611 389 63162998
Tooth disorder 36.14 10.38 258 325377 27899 63135488
Mitochondrial DNA mutation 35.91 10.38 24 325611 398 63162989
Frequent bowel movements 35.89 10.38 39 325596 22983 63140404
Impaired quality of life 35.68 10.38 13 325622 13770 63149617
Exposure during pregnancy 35.56 10.38 572 325063 154975 63008412
Peripheral sensorimotor neuropathy 35.23 10.38 41 325594 1462 63161925
Leukoencephalopathy 35.12 10.38 73 325562 4340 63159047
Epistaxis 35.09 10.38 546 325089 72179 63091208
Joint dislocation 35.06 10.38 27 325608 18773 63144614
Feeling hot 35.06 10.38 404 325231 49950 63113437
Poor venous access 34.94 10.38 16 325619 14769 63148618
Cryptococcosis 34.84 10.38 36 325599 1121 63162266
Diffuse large B-cell lymphoma refractory 34.76 10.38 37 325598 1193 63162194
Salmonella sepsis 34.72 10.38 20 325615 251 63163136
Spinal cord compression 34.65 10.38 70 325565 4078 63159309
Meningitis listeria 34.58 10.38 28 325607 631 63162756
Hyperbilirubinaemia 34.52 10.38 132 325503 11182 63152205
Chorioretinopathy 34.52 10.38 31 325604 808 63162579
Acute kidney injury 34.51 10.38 1667 323968 261748 62901639
Pulmonary fibrosis 34.26 10.38 98 325537 39711 63123676
Bone density decreased 34.24 10.38 16 325619 14596 63148791
Underdose 34.12 10.38 55 325580 27401 63135986
Infective pulmonary exacerbation of cystic fibrosis 34.09 10.38 3 325632 8814 63154573
Acute myeloid leukaemia 34.06 10.38 176 325459 16971 63146416
Propofol infusion syndrome 34.04 10.38 33 325602 950 63162437
Blood pressure systolic abnormal 34.03 10.38 13 325622 13373 63150014
Jugular vein thrombosis 34.02 10.38 59 325576 3059 63160328
Eosinophilia 33.89 10.38 40 325595 22716 63140671
Lower respiratory tract infection 33.87 10.38 476 325159 131831 63031556
Pseudomonal sepsis 33.79 10.38 51 325584 2350 63161037
Light chain analysis abnormal 33.72 10.38 17 325618 160 63163227
Neuroleptic malignant syndrome 33.62 10.38 10 325625 12046 63151341
Refractory cytopenia with multilineage dysplasia 33.53 10.38 16 325619 132 63163255
Pulmonary mucormycosis 33.40 10.38 21 325614 312 63163075
Cholecystectomy 33.37 10.38 7 325628 10670 63152717
Product prescribing error 33.30 10.38 52 325583 26237 63137150
Platelet count abnormal 33.29 10.38 61 325574 3303 63160084
Enthesopathy 33.12 10.38 3 325632 8611 63154776
Acute interstitial pneumonitis 32.96 10.38 28 325607 676 63162711
Gastrointestinal perforation 32.92 10.38 62 325573 3429 63159958
Blood culture positive 32.74 10.38 74 325561 4661 63158726
Stridor 32.68 10.38 62 325573 3448 63159939
Glioblastoma 32.62 10.38 30 325605 807 63162580
Pneumonia cytomegaloviral 32.55 10.38 48 325587 2166 63161221
Somnolence 32.44 10.38 684 324951 178001 62985386
Enterobacter infection 32.34 10.38 48 325587 2179 63161208
Low birth weight baby 32.28 10.38 95 325540 7034 63156353
Blood fibrinogen decreased 32.14 10.38 30 325605 823 63162564
Poisoning 32.11 10.38 15 325620 13685 63149702
White blood cell count abnormal 31.99 10.38 87 325548 6155 63157232
Hyperaemia 31.81 10.38 48 325587 2211 63161176
Chronic sinusitis 31.78 10.38 13 325622 12830 63150557
Disease recurrence 31.55 10.38 249 325386 27781 63135606
Tremor 31.51 10.38 895 324740 131344 63032043
Pseudomonas test positive 31.49 10.38 28 325607 720 63162667
Radiation skin injury 31.43 10.38 31 325604 912 63162475
Iris atrophy 31.28 10.38 13 325622 74 63163313
Adrenogenital syndrome 31.27 10.38 11 325624 36 63163351
Myalgia 31.16 10.38 546 325089 145983 63017404
Oral candidiasis 31.09 10.38 212 325423 22586 63140801
Coombs indirect test positive 31.04 10.38 11 325624 37 63163350
Respiratory tract infection 30.77 10.38 337 325298 41146 63122241
Nocardiosis 30.74 10.38 44 325591 1932 63161455
Anxiety 30.66 10.38 865 324770 216676 62946711
Performance status decreased 30.64 10.38 62 325573 3616 63159771
Foot fracture 30.58 10.38 47 325588 23867 63139520
Escherichia infection 30.44 10.38 138 325497 12616 63150771
Deformity 30.28 10.38 11 325624 11673 63151714
Enterocolitis 30.28 10.38 99 325536 7759 63155628
Drug tolerance decreased 30.23 10.38 27 325608 17446 63145941
Cardiopulmonary failure 30.22 10.38 61 325574 3551 63159836
Paraproteinaemia 30.15 10.38 16 325619 169 63163218
Staphylococcal sepsis 30.07 10.38 101 325534 8027 63155360
Hiatus hernia 30.03 10.38 40 325595 21554 63141833
Gastrointestinal fungal infection 30.01 10.38 20 325615 330 63163057
Pupillary deformity 29.95 10.38 7 325628 0 63163387
Alopecia areata 29.93 10.38 40 325595 1645 63161742
Iron deficiency anaemia 29.85 10.38 35 325600 19934 63143453
Skin discolouration 29.78 10.38 311 325324 37517 63125870
Accidental overdose 29.63 10.38 46 325589 23263 63140124
Ovarian cyst 29.61 10.38 23 325612 15922 63147465
Perineal necrosis 29.60 10.38 14 325621 113 63163274
Electrolyte imbalance 29.37 10.38 190 325445 19886 63143501
Intentional product use issue 29.33 10.38 470 325165 127422 63035965
Urticaria 29.13 10.38 638 324997 165164 62998223
Corneal disorder 29.11 10.38 41 325594 1773 63161614
Food allergy 29.10 10.38 11 325624 11390 63151997
Adrenal insufficiency 29.00 10.38 174 325461 17741 63145646
Spinal operation 28.98 10.38 4 325631 8267 63155120
Heavy menstrual bleeding 28.95 10.38 29 325606 17744 63145643
Ascites 28.91 10.38 328 325307 40400 63122987
Fusarium infection 28.84 10.38 25 325610 621 63162766
Depressed level of consciousness 28.80 10.38 193 325442 61885 63101502
Heart block congenital 28.72 10.38 8 325627 8 63163379
Prescribed underdose 28.67 10.38 69 325566 29620 63133767
Malaise 28.56 10.38 1795 323840 414159 62749228
Klebsiella bacteraemia 28.54 10.38 39 325596 1639 63161748
Pneumonia bacterial 28.53 10.38 110 325525 9355 63154032
Parkinsonism 28.50 10.38 9 325626 10430 63152957
Acute respiratory failure 28.33 10.38 286 325349 34199 63129188
Device malfunction 28.11 10.38 30 325605 17827 63145560
Metastases to meninges 28.08 10.38 49 325586 2553 63160834
Hypopyon 28.07 10.38 26 325609 706 63162681
JC virus infection 28.06 10.38 43 325592 2008 63161379
Device breakage 28.05 10.38 12 325623 11530 63151857
Right ventricular failure 28.05 10.38 28 325607 17160 63146227
Central nervous system leukaemia 28.02 10.38 14 325621 129 63163258
Infusion related reaction 27.93 10.38 1004 324631 244517 62918870
Body dysmorphic disorder 27.92 10.38 19 325616 325 63163062
Sleep disorder due to a general medical condition 27.57 10.38 14 325621 12174 63151213
Colitis microscopic 27.44 10.38 7 325628 9332 63154055
Herpes simplex oesophagitis 27.36 10.38 15 325620 170 63163217
Thrombotic microangiopathy 27.28 10.38 117 325518 10444 63152943
Pruritus 27.26 10.38 1546 324089 359907 62803480
Human herpesvirus 6 infection 27.24 10.38 52 325583 2905 63160482
Perineal infection 27.21 10.38 14 325621 138 63163249
Chalazion 27.07 10.38 20 325615 392 63162995
Glycosylated haemoglobin increased 26.93 10.38 15 325620 12383 63151004
Ocular hypertension 26.91 10.38 30 325605 1020 63162367
Throat tightness 26.88 10.38 219 325416 24668 63138719
Gastrooesophageal reflux disease 26.68 10.38 338 325297 95301 63068086
Pre-existing condition improved 26.61 10.38 5 325630 8239 63155148
Medication error 26.60 10.38 158 325477 52126 63111261
Pseudocellulitis 26.57 10.38 8 325627 13 63163374
Atelectasis 26.51 10.38 195 325440 21288 63142099
Herpes simplex 26.48 10.38 98 325537 8173 63155214
Bacterial sepsis 26.42 10.38 61 325574 3897 63159490
Sternal fracture 26.37 10.38 44 325591 2210 63161177
Obstructive airways disorder 26.16 10.38 41 325594 20658 63142729
Cholelithiasis 26.09 10.38 126 325509 43799 63119588
Red blood cell count decreased 26.05 10.38 321 325314 40324 63123063
Keratitis fungal 25.97 10.38 14 325621 153 63163234
Escherichia sepsis 25.88 10.38 70 325565 4937 63158450
Escherichia test positive 25.86 10.38 45 325590 2339 63161048
Pulmonary sepsis 25.86 10.38 36 325599 1540 63161847
Corneal opacity 25.84 10.38 25 325610 718 63162669
Therapeutic response unexpected 25.83 10.38 35 325600 18724 63144663
Depressed mood 25.83 10.38 112 325523 40079 63123308
Tardive dyskinesia 25.71 10.38 6 325629 8496 63154891
Hordeolum 25.67 10.38 54 325581 3238 63160149
Partial seizures 25.64 10.38 77 325558 5765 63157622
Tendonitis 25.61 10.38 38 325597 19577 63143810
Haematochezia 25.58 10.38 165 325470 53379 63110008
Alpha haemolytic streptococcal infection 25.51 10.38 32 325603 1235 63162152
Blood calcium abnormal 25.49 10.38 32 325603 1236 63162151
Pulmonary haemorrhage 25.48 10.38 88 325547 7093 63156294
Road traffic accident 25.47 10.38 99 325536 36533 63126854
Crossmatch incompatible 25.46 10.38 9 325626 30 63163357
Fear 25.37 10.38 26 325609 15740 63147647
Listeriosis 25.34 10.38 35 325600 1486 63161901
Staphylococcal bacteraemia 25.33 10.38 74 325561 5456 63157931
Adverse event 25.25 10.38 223 325412 67336 63096051
Hypertransaminasaemia 25.23 10.38 83 325552 6526 63156861
Drug tolerance 25.22 10.38 3 325632 6946 63156441
Urosepsis 25.10 10.38 172 325463 18352 63145035
Neoplasm recurrence 25.06 10.38 47 325588 2591 63160796
Type I hypersensitivity 24.99 10.38 50 325585 2892 63160495
Mantle cell lymphoma recurrent 24.94 10.38 15 325620 205 63163182
Hyperglycaemic hyperosmolar nonketotic syndrome 24.91 10.38 28 325607 961 63162426
Enteritis 24.73 10.38 96 325539 8190 63155197
Musculoskeletal chest pain 24.68 10.38 189 325446 20894 63142493
Product dispensing error 24.59 10.38 11 325624 10294 63153093
Cardiac failure 24.58 10.38 615 325020 88527 63074860
Hyperamylasaemia 24.36 10.38 20 325615 460 63162927
Lip swelling 24.22 10.38 80 325555 30983 63132404
Sensitivity to weather change 24.21 10.38 4 325631 7233 63156154
Alveolitis 24.12 10.38 49 325586 2866 63160521
Nervous system disorder 24.11 10.38 172 325463 18594 63144793
Pneumonia viral 23.82 10.38 92 325543 7830 63155557
Dermatitis atopic 23.81 10.38 10 325625 9714 63153673
Spinal fracture 23.79 10.38 168 325467 18103 63145284
Nasal abscess 23.68 10.38 14 325621 185 63163202
Movement disorder 23.67 10.38 47 325588 21614 63141773
Mesenteric abscess 23.66 10.38 11 325624 85 63163302
Hereditary angioedema 23.54 10.38 5 325630 7557 63155830
Disability 23.52 10.38 36 325599 18311 63145076
Allergy test negative 23.36 10.38 14 325621 190 63163197
Lymphoedema 23.22 10.38 120 325515 11572 63151815
Blood magnesium decreased 23.19 10.38 131 325504 13067 63150320
Hallucination, auditory 23.18 10.38 19 325616 12805 63150582
Intervertebral disc degeneration 23.06 10.38 28 325607 15704 63147683
Ear infection 23.05 10.38 109 325526 38104 63125283
Amenorrhoea 23.01 10.38 11 325624 9903 63153484
Autonomic neuropathy 22.91 10.38 29 325606 1130 63162257
Chemotherapy 22.88 10.38 34 325601 1545 63161842
Malignant neoplasm of unknown primary site 22.77 10.38 16 325619 289 63163098
Large intestinal ulcer perforation 22.71 10.38 10 325625 67 63163320
Breast cancer stage I 22.62 10.38 4 325631 6885 63156502
Hyperproteinaemia 22.53 10.38 11 325624 96 63163291
Product packaging confusion 22.51 10.38 13 325622 164 63163223
Hypomagnesaemia 22.50 10.38 236 325399 28501 63134886
Lung infiltration 22.48 10.38 139 325496 14324 63149063
Nightmare 22.43 10.38 40 325595 19154 63144233
Extrapyramidal disorder 22.42 10.38 21 325614 13263 63150124
Antithrombin III decreased 22.38 10.38 15 325620 250 63163137
Pneumomediastinum 22.37 10.38 32 325603 1404 63161983
Superficial spreading melanoma stage unspecified 22.35 10.38 12 325623 130 63163257
Cerebral aspergillosis 22.29 10.38 18 325617 404 63162983
Serotonin syndrome 22.27 10.38 74 325561 28608 63134779
Madarosis 22.26 10.38 49 325586 3032 63160355
Hypothyroidism 22.13 10.38 128 325507 42504 63120883
Enterococcal bacteraemia 21.98 10.38 32 325603 1427 63161960
Joint destruction 21.96 10.38 3 325632 6249 63157138
Bone marrow infiltration 21.90 10.38 22 325613 662 63162725
Stem cell transplant 21.90 10.38 36 325599 1786 63161601
Encephalitis 21.88 10.38 97 325538 8783 63154604
Meningitis pneumococcal 21.82 10.38 15 325620 261 63163126
Secondary immunodeficiency 21.81 10.38 31 325604 1352 63162035
Maternal exposure before pregnancy 21.77 10.38 6 325629 7597 63155790
Neck pain 21.63 10.38 239 325396 69079 63094308
Erysipelas 21.52 10.38 89 325546 7816 63155571
Pneumococcal sepsis 21.47 10.38 22 325613 678 63162709
Temperature regulation disorder 21.40 10.38 3 325632 6129 63157258
Adverse drug reaction 21.40 10.38 548 325087 79166 63084221
Eosinophil count increased 21.28 10.38 15 325620 10913 63152474
Oral disorder 21.28 10.38 96 325539 8758 63154629
Enterococcal sepsis 21.22 10.38 31 325604 1387 63162000
Bone infarction 21.17 10.38 16 325619 325 63163062
Choroiditis 21.16 10.38 13 325622 185 63163202
Vascular pain 21.13 10.38 23 325612 761 63162626
Leukaemia recurrent 21.12 10.38 30 325605 1308 63162079
Drug level increased 21.05 10.38 54 325581 22682 63140705
Cerebral venous thrombosis 21.02 10.38 38 325597 2036 63161351
Recall phenomenon 20.98 10.38 21 325614 629 63162758
Cytomegalovirus colitis 20.98 10.38 41 325594 2331 63161056
Infusion site swelling 20.96 10.38 12 325623 9758 63153629
Ileus paralytic 20.94 10.38 61 325574 4490 63158897
T-cell lymphoma refractory 20.86 10.38 9 325626 57 63163330
Gastrointestinal protozoal infection 20.86 10.38 7 325628 19 63163368
Gastrointestinal disorder 20.81 10.38 513 325122 130726 63032661
Atrial septal defect 20.77 10.38 5 325630 6933 63156454
Urinary tract infection 20.72 10.38 1601 324034 263083 62900304
Clostridium bacteraemia 20.69 10.38 13 325622 193 63163194
Anaphylactic reaction 20.66 10.38 464 325171 65636 63097751
Klebsiella sepsis 20.61 10.38 31 325604 1424 63161963
Swelling face 20.60 10.38 448 325187 63027 63100360
Phaeochromocytoma crisis 20.60 10.38 14 325621 239 63163148
Illness 20.58 10.38 157 325478 48902 63114485
Grip strength decreased 20.58 10.38 53 325582 22234 63141153
Platelet disorder 20.57 10.38 36 325599 1880 63161507
Therapeutic response decreased 20.47 10.38 209 325426 61316 63102071
Nail dystrophy 20.46 10.38 26 325609 1017 63162370
Rhinitis allergic 20.44 10.38 18 325617 11709 63151678
Multiple allergies 20.42 10.38 131 325504 13671 63149716
Product administration error 20.12 10.38 54 325581 22343 63141044
Birdshot chorioretinopathy 20.11 10.38 9 325626 63 63163324
Palmar erythema 20.02 10.38 34 325601 1733 63161654
Tonsillar disorder 19.92 10.38 27 325608 1126 63162261
Hysterectomy 19.91 10.38 12 325623 9487 63153900
Streptococcal bacteraemia 19.88 10.38 34 325601 1743 63161644
Gastroenteritis norovirus 19.84 10.38 37 325598 2031 63161356
Mucocutaneous ulceration 19.83 10.38 12 325623 166 63163221
Adenocarcinoma pancreas 19.78 10.38 26 325609 1052 63162335
Hyperkalaemia 19.78 10.38 180 325455 54023 63109364
Scar 19.71 10.38 25 325610 13757 63149630
Hypothalamic pituitary adrenal axis suppression 19.70 10.38 12 325623 168 63163219
Varicella zoster virus infection 19.69 10.38 43 325592 2646 63160741
Protein urine 19.69 10.38 22 325613 750 63162637
Venous thrombosis limb 19.68 10.38 46 325589 2962 63160425
Anticipatory anxiety 19.67 10.38 28 325607 1223 63162164
Intermenstrual bleeding 19.65 10.38 8 325627 7918 63155469
Hair texture abnormal 19.65 10.38 57 325578 4186 63159201
Subclavian vein thrombosis 19.63 10.38 35 325600 1855 63161532
Oesophageal squamous cell carcinoma 19.59 10.38 11 325624 131 63163256
Device leakage 19.58 10.38 6 325629 7090 63156297
Adenocarcinoma of colon 19.44 10.38 41 325594 2463 63160924
Babesiosis 19.43 10.38 13 325622 216 63163171
Precursor B-lymphoblastic lymphoma 19.23 10.38 7 325628 26 63163361
Angina pectoris 19.22 10.38 84 325551 29994 63133393
Coronary artery occlusion 19.15 10.38 9 325626 8182 63155205
Endocarditis 19.14 10.38 69 325566 5681 63157706
Eastern Cooperative Oncology Group performance status improved 19.14 10.38 6 325629 12 63163375
Dysphonia 19.13 10.38 347 325288 47267 63116120
Blood gases abnormal 19.12 10.38 22 325613 775 63162612
Enlarged uvula 19.10 10.38 12 325623 178 63163209
Spinal fusion surgery 19.08 10.38 3 325632 5625 63157762
Refractory anaemia with ringed sideroblasts 19.06 10.38 5 325630 3 63163384
Product substitution issue 18.99 10.38 33 325602 15963 63147424
Soft tissue infection 18.98 10.38 37 325598 2100 63161287
Arachnoiditis 18.95 10.38 15 325620 327 63163060
Polyp 18.95 10.38 5 325630 6516 63156871
Miosis 18.93 10.38 7 325628 7346 63156041
CSF oligoclonal band present 18.92 10.38 16 325619 384 63163003
Lactose intolerance 18.90 10.38 45 325590 2933 63160454
Exposure to toxic agent 18.89 10.38 3 325632 5584 63157803
Appendicitis 18.87 10.38 88 325547 8141 63155246
Cancer pain 18.82 10.38 47 325588 3158 63160229
Haemolytic anaemia 18.79 10.38 102 325533 10023 63153364
Tuberculoma of central nervous system 18.75 10.38 15 325620 332 63163055
Philadelphia chromosome positive 18.71 10.38 16 325619 390 63162997
Meningoencephalitis herpetic 18.67 10.38 27 325608 1197 63162190
Nodule 18.66 10.38 51 325584 20975 63142412
Abnormal dreams 18.50 10.38 16 325619 10500 63152887
Hyphaema 18.49 10.38 14 325621 285 63163102
Panic attack 18.47 10.38 56 325579 22275 63141112
Spinal stenosis 18.45 10.38 30 325605 14895 63148492
Pseudomyopia 18.37 10.38 8 325627 52 63163335
Product dose omission in error 18.36 10.38 8 325627 7604 63155783
Tachycardia 18.35 10.38 761 324874 117395 63045992
Ankle brachial index decreased 18.29 10.38 9 325626 80 63163307
Pulse waveform abnormal 18.29 10.38 9 325626 80 63163307
Encephalopathy 18.26 10.38 289 325346 38331 63125056
Tracheal deviation 18.25 10.38 11 325624 151 63163236
C-reactive protein increased 18.22 10.38 359 325276 94348 63069039
Intraocular pressure decreased 18.19 10.38 10 325625 114 63163273
Nail infection 18.08 10.38 40 325595 2483 63160904
Atypical pneumonia 18.07 10.38 57 325578 4383 63159004
Vitamin D deficiency 18.06 10.38 27 325608 13865 63149522
Hypertension 18.00 10.38 1212 324423 278091 62885296
Escherichia urinary tract infection 17.99 10.38 114 325521 11848 63151539
Mood swings 17.94 10.38 42 325593 18206 63145181
Respiratory depth decreased 17.91 10.38 7 325628 33 63163354
Carotid intima-media thickness increased 17.91 10.38 9 325626 84 63163303
Hallucination 17.91 10.38 187 325448 54630 63108757
Blood pressure diastolic increased 17.89 10.38 15 325620 9995 63153392
Catabolic state 17.88 10.38 8 325627 56 63163331
Compression fracture 17.87 10.38 73 325562 6375 63157012
Hypotension 17.86 10.38 1627 324008 270977 62892410
Seasonal allergy 17.81 10.38 175 325460 20775 63142612
Spinal osteoarthritis 17.79 10.38 35 325600 16151 63147236
Diverticular perforation 17.79 10.38 49 325586 3493 63159894
Virilism 17.75 10.38 7 325628 34 63163353
Herpes simplex reactivation 17.69 10.38 18 325617 550 63162837
Myopathy 17.67 10.38 108 325527 11083 63152304
Oral pain 17.66 10.38 223 325412 28171 63135216
Heart rate decreased 17.64 10.38 149 325486 45411 63117976
Meningitis cryptococcal 17.63 10.38 28 325607 1349 63162038
Lymphoma 17.62 10.38 115 325520 12072 63151315
Endocarditis bacterial 17.59 10.38 19 325616 623 63162764
Circulatory collapse 17.57 10.38 181 325454 21757 63141630
Cerebellar haemangioma 17.56 10.38 9 325626 88 63163299
Device use error 17.55 10.38 4 325631 5757 63157630
Dermatitis acneiform 17.53 10.38 61 325574 4935 63158452
Eosinophilic cystitis 17.52 10.38 8 325627 59 63163328
Gene mutation 17.51 10.38 31 325604 1634 63161753
Menstruation irregular 17.48 10.38 7 325628 6997 63156390
Second primary malignancy 17.47 10.38 84 325551 7869 63155518
Procalcitonin abnormal 17.44 10.38 6 325629 18 63163369
Meningitis 17.39 10.38 78 325557 7099 63156288
Refractory anaemia with an excess of blasts 17.38 10.38 16 325619 431 63162956
Soft tissue disorder 17.30 10.38 56 325579 4366 63159021
Cardiac murmur 17.30 10.38 30 325605 14522 63148865
Akathisia 17.23 10.38 13 325622 9133 63154254
Insurance issue 17.21 10.38 5 325630 6116 63157271
Metastatic malignant melanoma 17.20 10.38 27 325608 1288 63162099
Myelopathy 17.18 10.38 42 325593 2784 63160603
Hypophagia 17.16 10.38 240 325395 31019 63132368
Listeria sepsis 17.14 10.38 20 325615 715 63162672
Fungaemia 17.11 10.38 38 325597 2365 63161022
Vitreous loss 17.11 10.38 4 325631 0 63163387
Klebsiella infection 17.07 10.38 88 325547 8478 63154909
Hyperpyrexia 17.02 10.38 49 325586 3583 63159804
Hypogeusia 16.95 10.38 27 325608 1304 63162083
Chronic myelomonocytic leukaemia 16.94 10.38 14 325621 325 63163062
Lymphocyte count decreased 16.89 10.38 233 325402 30024 63133363
Device adhesion issue 16.85 10.38 3 325632 5138 63158249
Cholecystitis chronic 16.77 10.38 17 325618 10344 63153043
Device failure 16.74 10.38 5 325630 6006 63157381
Sinus polyp 16.73 10.38 15 325620 390 63162997
Spinal compression fracture 16.69 10.38 128 325507 14155 63149232
Thiopurine methyltransferase decreased 16.66 10.38 14 325621 333 63163054
Anhedonia 16.65 10.38 19 325616 10955 63152432
Tooth erosion 16.61 10.38 16 325619 457 63162930
Hypoglobulinaemia 16.54 10.38 7 325628 42 63163345
Necrotising retinitis 16.51 10.38 15 325620 397 63162990
Creatinine renal clearance decreased 16.47 10.38 37 325598 16271 63147116
Vein discolouration 16.47 10.38 12 325623 230 63163157
Neurological symptom 16.45 10.38 66 325569 5717 63157670
Incorrect product administration duration 16.45 10.38 21 325614 11525 63151862
Skin candida 16.36 10.38 30 325605 1625 63161762
Bone debridement 16.34 10.38 12 325623 233 63163154
Enterocolitis infectious 16.33 10.38 30 325605 1628 63161759
Phrenic nerve paralysis 16.32 10.38 11 325624 185 63163202
Fungal abscess central nervous system 16.29 10.38 5 325630 9 63163378
Necrotising fasciitis 16.21 10.38 43 325592 2998 63160389
Acne 16.16 10.38 63 325572 23230 63140157
N-terminal prohormone brain natriuretic peptide decreased 16.13 10.38 6 325629 24 63163363
Intracranial mass 16.09 10.38 25 325610 1182 63162205
Eye abscess 16.06 10.38 10 325625 146 63163241
Foetal growth restriction 16.04 10.38 79 325556 7474 63155913
Confusional state 16.03 10.38 1021 324614 235359 62928028
Visceral leishmaniasis 16.03 10.38 17 325618 546 63162841
Polyarthritis 16.02 10.38 17 325618 10129 63153258
Aggression 16.02 10.38 64 325571 23434 63139953
Cholangitis infective 16.01 10.38 14 325621 352 63163035
Bronchiectasis 16.00 10.38 37 325598 16105 63147282
Blood alkaline phosphatase abnormal 15.98 10.38