desoxycortone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| corticosteroids, except prednisolone derivatives | 820 | 64-85-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 5 | mg | O |
| 5 | mg | P |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | H02AA03 | SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS CORTICOSTEROIDS FOR SYSTEMIC USE CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN Mineralocorticoids |
| MeSH PA | D006728 | Hormones |
| MeSH PA | D008901 | Mineralocorticoids |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.85 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Mineralocorticoid receptor | Nuclear hormone receptor | AGONIST | IC50 | 11 | IUPHAR | CHEMBL | |||
| 5-hydroxytryptamine receptor 2A | GPCR | Ki | 8.85 | PDSP | |||||
| 5-hydroxytryptamine receptor 2B | GPCR | Ki | 7.50 | PDSP | |||||
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | IC50 | 7.20 | IUPHAR | ||||
| Corticosteroid-binding globulin | Secreted | Ki | 7.65 | CHEMBL | |||||
| Sex hormone-binding globulin | Secreted | Kd | 7.38 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 2C | GPCR | Ki | 8.70 | PDSP |
External reference:
| ID | Source |
|---|---|
| 4019710 | VUID |
| N0000147802 | NUI |
| D07792 | KEGG_DRUG |
| 3256 | RXNORM |
| 4019710 | VANDF |
| C0011710 | UMLSCUI |
| CHEBI:16973 | CHEBI |
| 1CA | PDB_CHEM_ID |
| CHEMBL1200542 | ChEMBL_ID |
| CHEMBL1498 | ChEMBL_ID |
| DB15972 | DRUGBANK_ID |
| 2871 | IUPHAR_LIGAND_ID |
| 387 | INN_ID |
| 40GP35YQ49 | UNII |
| 6166 | PUBCHEM_CID |
| 002207 | NDDF |
| 1336006 | SNOMEDCT_US |
| 56156001 | SNOMEDCT_US |
| 75029008 | SNOMEDCT_US |
| D003900 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
None