desflurane 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
halogenated compounds used as general inhalation anaesthetics 811 57041-67-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • Difluoromethyl 1,2,2,2-tetrafluoroethyl ether
  • desflurane
A fluorinated ether that is used as a volatile anesthetic for maintenance of general anesthesia.
  • Molecular weight: 168.04
  • Formula: C3H2F6O
  • CLOGP: 1.51
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 9.23
  • ALOGS: -1.68
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIK3CG,PRKDC,SIK2,STK33,TEK,TTK 29
kinase-selectivity-class PDK1,PDK2 2
pfas-class PFAS structural alert (1 = True, 0 = False) 1

Approvals:

DateAgencyCompanyOrphan
Sept. 18, 1992 FDA BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic shock 143.51 41.37 42 1450 31575 90595380
Hyperthermia malignant 96.66 41.37 17 1475 1281 90625674
Procedural hypotension 93.11 41.37 17 1475 1583 90625372
Bradycardia 89.81 41.37 38 1454 83809 90543146
Serotonin syndrome 87.11 41.37 30 1462 37857 90589098
Neuromuscular block prolonged 86.50 41.37 14 1478 638 90626317
Vocal cord dysfunction 81.78 41.37 14 1478 900 90626055
Cardiac arrest 81.63 41.37 38 1454 104897 90522058
Delayed recovery from anaesthesia 66.81 41.37 12 1480 1018 90625937
Anaphylactic reaction 56.75 41.37 28 1464 87496 90539459
Drug interaction 56.36 41.37 42 1450 276411 90350544
Bronchospasm 49.89 41.37 17 1475 20692 90606263
Vitamin K deficiency 46.98 41.37 8 1484 497 90626458
Respiratory depression 42.32 41.37 14 1478 15561 90611394
Unwanted awareness during anaesthesia 41.63 41.37 7 1485 403 90626552

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthermia malignant 190.20 41.52 37 1262 2621 42617415
Anaphylactic shock 110.16 41.52 37 1262 23480 42596556
Serotonin syndrome 83.99 41.52 31 1268 25814 42594222
Seizure like phenomena 82.86 41.52 16 1283 1081 42618955
Bronchospasm 71.21 41.52 23 1276 12862 42607174
Neuromuscular block prolonged 59.12 41.52 11 1288 608 42619428
Trigemino-cardiac reflex 51.16 41.52 9 1290 362 42619674
Hypotension 51.11 41.52 50 1249 257581 42362455
Anticholinergic syndrome 43.39 41.52 10 1289 1579 42618457
Cardiac arrest 41.77 41.52 31 1268 109289 42510747

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthermia malignant 271.87 37.76 52 2889 3848 110582510
Anaphylactic shock 231.49 37.76 76 2865 51470 110534888
Serotonin syndrome 164.31 37.76 61 2880 59092 110527266
Neuromuscular block prolonged 140.77 37.76 25 2916 1222 110585136
Bronchospasm 113.43 37.76 39 2902 30200 110556158
Bradycardia 107.85 37.76 61 2880 155456 110430902
Cardiac arrest 107.16 37.76 66 2875 196687 110389671
Delayed recovery from anaesthesia 102.54 37.76 21 2920 2194 110584164
Post procedural complication 94.62 37.76 33 2908 26625 110559733
Drug interaction 83.11 37.76 83 2858 500100 110086258
Procedural hypotension 82.91 37.76 18 2923 2487 110583871
Anaphylactic reaction 79.61 37.76 45 2896 114255 110472103
Hypotension 78.08 37.76 82 2859 523767 110062591
Circulatory collapse 75.92 37.76 32 2909 42961 110543397
Vocal cord dysfunction 74.50 37.76 14 2927 936 110585422
Seizure like phenomena 72.22 37.76 16 2925 2425 110583933
Trigemino-cardiac reflex 63.59 37.76 11 2930 460 110585898
Anticholinergic syndrome 58.37 37.76 15 2926 4265 110582093
Laryngospasm 57.08 37.76 15 2926 4653 110581705
Recurrence of neuromuscular blockade 51.02 37.76 9 2932 422 110585936
Ventricular tachycardia 46.85 37.76 24 2917 49985 110536373
Unwanted awareness during anaesthesia 44.83 37.76 8 2933 401 110585957
Blood pressure decreased 43.97 37.76 31 2910 115060 110471298
Tachycardia 40.04 37.76 39 2902 226606 110359752
Vitamin K deficiency 38.35 37.76 8 2933 913 110585445
Respiratory depression 37.83 37.76 18 2923 31983 110554375

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N01AB07 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Halogenated hydrocarbons
MeSH PA D000777 Anesthetics
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018685 Anesthetics, Inhalation
CHEBI has role CHEBI:38870 inhalation anaesthetic
FDA EPC N0000175681 General Anesthetic
FDA PE N0000175975 General Anesthesia

Related Drugs by ATC class:

N01AB Halogenated hydrocarbons 6 drugs
chloroformenfluranehalothaneisofluranesevofluranetrichloroethylene

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003
Hyperkalemia contraindication 14140009
Cirrhosis of liver contraindication 19943007 DOID:5082
Viral hepatitis C contraindication 50711007 DOID:1883
Viral hepatitis type B contraindication 66071002 DOID:2043
Benign intracranial hypertension contraindication 68267002 DOID:11459
Duchenne muscular dystrophy contraindication 76670001 DOID:11723
Myasthenia gravis contraindication 91637004 DOID:437
Disease of liver contraindication 235856003 DOID:409
Neuromyopathy contraindication 255522009 DOID:440
Familial periodic paralysis contraindication 267607008 DOID:1029
Lesion of brain contraindication 301766008
Malignant hyperthermia contraindication 405501007
Disorder of coronary artery contraindication 414024009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Potassium channel subfamily K member 2 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 3 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 9 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 10 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 18 Ion channel OPENER CHEMBL CHEMBL
Glycine receptor (alpha-1/beta) Ion channel POSITIVE MODULATOR CHEMBL CHEMBL
GABA-A receptor; anion channel Ion channel POSITIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL

External reference:

IDSource
4020649 VUID
N0000148295 NUI
D00546 KEGG_DRUG
27340 RXNORM
4020649 VANDF
C0063252 UMLSCUI
CHEBI:4445 CHEBI
DSF PDB_CHEM_ID
CHEMBL1200733 ChEMBL_ID
DB01189 DRUGBANK_ID
D000077335 MESH_DESCRIPTOR_UI
42113 PUBCHEM_CID
6505 INN_ID
7156 IUPHAR_LIGAND_ID
CRS35BZ94Q UNII
247482 MMSL
399944 MMSL
4545 MMSL
d02374 MMSL
004114 NDDF
108393001 SNOMEDCT_US
386841003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Suprane HUMAN PRESCRIPTION DRUG LABEL 1 0404-9961 LIQUID 240 mL RESPIRATORY (INHALATION) NDA 17 sections
Suprane HUMAN PRESCRIPTION DRUG LABEL 1 0404-9961 LIQUID 240 mL RESPIRATORY (INHALATION) NDA 17 sections
Desflurane HUMAN PRESCRIPTION DRUG LABEL 1 0781-6172 LIQUID 240 mL RESPIRATORY (INHALATION) ANDA 28 sections
SUPRANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-641 LIQUID 240 mL RESPIRATORY (INHALATION) NDA 26 sections
SUPRANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-641 LIQUID 240 mL RESPIRATORY (INHALATION) NDA 26 sections
Suprane HUMAN PRESCRIPTION DRUG LABEL 1 10019-644 LIQUID 240 mL RESPIRATORY (INHALATION) NDA 28 sections
Suprane HUMAN PRESCRIPTION DRUG LABEL 1 10019-644 LIQUID 240 mL RESPIRATORY (INHALATION) NDA 28 sections
SUPRANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-646 LIQUID 240 mL RESPIRATORY (INHALATION) NDA 27 sections
SUPRANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-646 LIQUID 240 mL RESPIRATORY (INHALATION) NDA 27 sections
Desflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-021 LIQUID 250 mL RESPIRATORY (INHALATION) unapproved drug other 18 sections
Desflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-021 LIQUID 250 mL RESPIRATORY (INHALATION) unapproved drug other 18 sections