Stem definition | Drug id | CAS RN |
---|---|---|
halogenated compounds used as general inhalation anaesthetics | 811 | 57041-67-5 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 18, 1992 | FDA | BAXTER HLTHCARE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Serotonin syndrome | 83.38 | 40.14 | 29 | 1244 | 24684 | 50579167 |
Procedural hypotension | 79.52 | 40.14 | 15 | 1258 | 1087 | 50602764 |
Neuromuscular block prolonged | 77.03 | 40.14 | 13 | 1260 | 498 | 50603353 |
Bradycardia | 68.46 | 40.14 | 33 | 1240 | 64393 | 50539458 |
Cardiac arrest | 65.93 | 40.14 | 35 | 1238 | 83616 | 50520235 |
Hyperthermia malignant | 65.72 | 40.14 | 12 | 1261 | 727 | 50603124 |
Anaphylactic shock | 61.64 | 40.14 | 22 | 1251 | 20133 | 50583718 |
Anaphylactic reaction | 58.34 | 40.14 | 28 | 1245 | 54027 | 50549824 |
Delayed recovery from anaesthesia | 46.57 | 40.14 | 9 | 1264 | 740 | 50603111 |
Vitamin K deficiency | 45.02 | 40.14 | 8 | 1265 | 415 | 50603436 |
Bronchospasm | 44.58 | 40.14 | 16 | 1257 | 14838 | 50589013 |
Unwanted awareness during anaesthesia | 41.21 | 40.14 | 7 | 1266 | 278 | 50603573 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hyperthermia malignant | 168.92 | 44.05 | 32 | 981 | 1752 | 29571762 |
Anaphylactic shock | 104.93 | 44.05 | 32 | 981 | 13304 | 29560210 |
Seizure like phenomena | 89.99 | 44.05 | 16 | 997 | 610 | 29572904 |
Serotonin syndrome | 72.92 | 44.05 | 26 | 987 | 17486 | 29556028 |
Bronchospasm | 58.56 | 44.05 | 19 | 994 | 9590 | 29563924 |
Neuromuscular block prolonged | 48.13 | 44.05 | 9 | 1004 | 454 | 29573060 |
Anticholinergic syndrome | 47.97 | 44.05 | 10 | 1003 | 884 | 29572630 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hyperthermia malignant | 215.10 | 34.96 | 42 | 2403 | 2417 | 64493870 |
Serotonin syndrome | 145.58 | 34.96 | 55 | 2390 | 39227 | 64457060 |
Anaphylactic shock | 144.07 | 34.96 | 51 | 2394 | 30277 | 64466010 |
Neuromuscular block prolonged | 118.65 | 34.96 | 22 | 2423 | 955 | 64495332 |
Bronchospasm | 97.36 | 34.96 | 35 | 2410 | 21647 | 64474640 |
Post procedural complication | 90.38 | 34.96 | 33 | 2412 | 21320 | 64474967 |
Cardiac arrest | 79.24 | 34.96 | 57 | 2388 | 154007 | 64342280 |
Bradycardia | 77.95 | 34.96 | 51 | 2394 | 118168 | 64378119 |
Anaphylactic reaction | 74.94 | 34.96 | 41 | 2404 | 68623 | 64427664 |
Delayed recovery from anaesthesia | 74.05 | 34.96 | 16 | 2429 | 1512 | 64494775 |
Seizure like phenomena | 72.81 | 34.96 | 16 | 2429 | 1636 | 64494651 |
Procedural hypotension | 70.70 | 34.96 | 16 | 2429 | 1870 | 64494417 |
Anticholinergic syndrome | 60.13 | 34.96 | 15 | 2430 | 2654 | 64493633 |
Trigemino-cardiac reflex | 52.95 | 34.96 | 9 | 2436 | 235 | 64496052 |
Drug interaction | 51.94 | 34.96 | 66 | 2379 | 362017 | 64134270 |
Circulatory collapse | 47.76 | 34.96 | 24 | 2421 | 33708 | 64462579 |
Hypotension | 47.75 | 34.96 | 65 | 2380 | 380909 | 64115378 |
Recurrence of neuromuscular blockade | 47.55 | 34.96 | 8 | 2437 | 196 | 64496091 |
Laryngospasm | 46.97 | 34.96 | 13 | 2432 | 3432 | 64492855 |
End-tidal CO2 increased | 38.50 | 34.96 | 5 | 2440 | 17 | 64496270 |
Unwanted awareness during anaesthesia | 38.34 | 34.96 | 7 | 2438 | 278 | 64496009 |
Procedural vomiting | 38.01 | 34.96 | 8 | 2437 | 666 | 64495621 |
Vitamin K deficiency | 37.95 | 34.96 | 8 | 2437 | 671 | 64495616 |
Procedural nausea | 37.78 | 34.96 | 8 | 2437 | 686 | 64495601 |
Subcutaneous emphysema | 36.03 | 34.96 | 9 | 2436 | 1600 | 64494687 |
None
Source | Code | Description |
---|---|---|
ATC | N01AB07 | NERVOUS SYSTEM ANESTHETICS ANESTHETICS, GENERAL Halogenated hydrocarbons |
CHEBI has role | CHEBI:38870 | inhalation anesthetics |
MeSH PA | D000777 | Anesthetics |
MeSH PA | D018685 | Anesthetics, Inhalation |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
FDA EPC | N0000175681 | General Anesthetic |
FDA PE | N0000175975 | General Anesthesia |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
General anesthesia | indication | 50697003 | |
Hyperkalemia | contraindication | 14140009 | |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Viral hepatitis C | contraindication | 50711007 | DOID:1883 |
Viral hepatitis type B | contraindication | 66071002 | DOID:2043 |
Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
Duchenne muscular dystrophy | contraindication | 76670001 | DOID:11723 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Neuromyopathy | contraindication | 255522009 | DOID:440 |
Familial periodic paralysis | contraindication | 267607008 | DOID:1029 |
Lesion of brain | contraindication | 301766008 | |
Malignant hyperthermia | contraindication | 405501007 | |
Disorder of coronary artery | contraindication | 414024009 |
None
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Potassium channel subfamily K member 2 | Ion channel | OPENER | CHEMBL | CHEMBL | |||||
Potassium channel subfamily K member 3 | Ion channel | OPENER | CHEMBL | CHEMBL | |||||
Potassium channel subfamily K member 9 | Ion channel | OPENER | CHEMBL | CHEMBL | |||||
Potassium channel subfamily K member 10 | Ion channel | OPENER | CHEMBL | CHEMBL | |||||
Potassium channel subfamily K member 18 | Ion channel | OPENER | CHEMBL | CHEMBL | |||||
Glycine receptor (alpha-1/beta) | Ion channel | POSITIVE MODULATOR | CHEMBL | CHEMBL | |||||
GABA-A receptor; anion channel | Ion channel | POSITIVE ALLOSTERIC MODULATOR | CHEMBL | CHEMBL |
ID | Source |
---|---|
4020649 | VUID |
N0000148295 | NUI |
D00546 | KEGG_DRUG |
27340 | RXNORM |
4020649 | VANDF |
C0063252 | UMLSCUI |
CHEBI:4445 | CHEBI |
DSF | PDB_CHEM_ID |
CHEMBL1200733 | ChEMBL_ID |
DB01189 | DRUGBANK_ID |
D000077335 | MESH_DESCRIPTOR_UI |
42113 | PUBCHEM_CID |
6505 | INN_ID |
7156 | IUPHAR_LIGAND_ID |
CRS35BZ94Q | UNII |
247482 | MMSL |
4545 | MMSL |
d02374 | MMSL |
004114 | NDDF |
108393001 | SNOMEDCT_US |
386841003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Suprane | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9961 | LIQUID | 240 mL | RESPIRATORY (INHALATION) | NDA | 23 sections |
Desflurane | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-6172 | LIQUID | 240 mL | RESPIRATORY (INHALATION) | ANDA | 27 sections |
SUPRANE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10019-641 | LIQUID | 240 mL | RESPIRATORY (INHALATION) | NDA | 26 sections |
Suprane | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10019-644 | LIQUID | 240 mL | RESPIRATORY (INHALATION) | NDA | 27 sections |
SUPRANE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10019-646 | LIQUID | 240 mL | RESPIRATORY (INHALATION) | NDA | 26 sections |
Suprane | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52584-641 | LIQUID | 240 mL | RESPIRATORY (INHALATION) | NDA | 23 sections |