decamethonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
quaternary ammonium compounds	789	156-74-1

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

decamethonium
decamethonium bromide
syncurine

Molecular weight: 258.49
Formula: C16H38N2
CLOGP: -6.97
LIPINSKI: 0
HAC: 2
HDO: 0
TPSA:
ALOGS: -7.67
ROTB: 11

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
May 21, 1975	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D009465	Neuromuscular Agents
MeSH PA	D009466	Neuromuscular Blocking Agents
MeSH PA	D009467	Neuromuscular Depolarizing Agents
MeSH PA	D018373	Peripheral Nervous System Agents
CHEBI has role	CHEBI:47958	muscarinic agonists
CHEBI has role	CHEBI:51371	muscle relaxants

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Muscle-type nicotinic acetylcholine receptor	Ion channel	P02708 P07510 P11230 Q04844 Q07001	ACHA_HUMAN ACHG_HUMAN ACHB_HUMAN ACHE_HUMAN ACHD_HUMAN	PARTIAL AGONIST				CHEMBL	CHEMBL
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN		Ki	7.60		PDSP
Acetylcholinesterase	Enzyme	P22303	ACES_HUMAN		IC50	5.23		CHEMBL
Histamine H3 receptor	GPCR	Q9Y5N1	HRH3_HUMAN		IC50	6.09		CHEMBL
Acetylcholinesterase	Enzyme		ACES_MOUSE		Ki	5.46		CHEMBL
Neuronal acetylcholine receptor; alpha4/beta2	Ion channel		ACHA4_RAT ACHB2_RAT		Ki	5.24		CHEMBL

External reference:

ID	Source
C0057231	UMLSCUI
CHEBI:41934	CHEBI
DME	PDB_CHEM_ID
CHEMBL1190	ChEMBL_ID
DB01245	DRUGBANK_ID
C033019	MESH_SUPPLEMENTAL_RECORD_UI
2968	PUBCHEM_CID
541-22-0	SECONDARY_CAS_RN
C1CG1S3T2W	UNII
002403	NDDF
004957	NDDF
39514001	SNOMEDCT_US
CHEMBL1134	ChEMBL_ID
1397	INN_ID

Pharmaceutical products:

None