Stem definition | Drug id | CAS RN |
---|---|---|
antibacterials, streptogramins, protein-synthesis inhibitors, pristinamycin derivatives | 778 | 112362-50-2 |
Dose | Unit | Route |
---|---|---|
1.50 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 4 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 4.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 15.20 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 0.39 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 16 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.82 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 0.74 hours | Lombardo F, Berellini G, Obach RS |
S (Water solubility) | 0.03 mg/mL | Bocci G, Oprea TI, Benet LZ |
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 21, 1999 | FDA |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | J01FG02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS Streptogramins |
FDA CS | M0022748 | Streptogramins |
FDA EPC | N0000175502 | Streptogramin Antibacterial |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
CHEBI has role | CHEBI:48001 | protein synthesis inhibitors |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Vancomycin resistant enterococcus | indication | 113727004 | |
Streptococcus pyogenes infection | indication | 302809008 | |
Complicated Skin and Skin Structure Staphylococcus Aureus Infection | indication | ||
Pyrexia of unknown origin | off-label use | 7520000 | |
Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Pseudomembranous enterocolitis | contraindication | 397683000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 12.67 | acidic |
pKa2 | 4.1 | Basic |
None
None
None
ID | Source |
---|---|
4021183 | VUID |
N0000179689 | NUI |
D00853 | KEGG_DRUG |
229369 | RXNORM |
4021183 | VANDF |
C0756085 | UMLSCUI |
CHEBI:4309 | CHEBI |
DOL | PDB_CHEM_ID |
CHEMBL1200937 | ChEMBL_ID |
DB01764 | DRUGBANK_ID |
C113826 | MESH_SUPPLEMENTAL_RECORD_UI |
10797 | IUPHAR_LIGAND_ID |
6581 | INN_ID |
R9M4FJE48E | UNII |
6323289 | PUBCHEM_CID |
8300 | MMSL |
d04456 | MMSL |
007888 | NDDF |
116111008 | SNOMEDCT_US |
387016001 | SNOMEDCT_US |
427378005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Synercid | HUMAN PRESCRIPTION DRUG LABEL | 2 | 61570-260 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 350 mg | INTRAVENOUS | NDA | 26 sections |
Synercid | HUMAN PRESCRIPTION DRUG LABEL | 2 | 61570-260 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 350 mg | INTRAVENOUS | NDA | 26 sections |