dabigatran etexilate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
thrombin inhibitors, antithrombotic agents 776 211915-06-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • BIBR 1048
  • BIBR-1048
  • dabigatran etexilate mesilate
  • dabigatran etexilate
  • pradaxa
  • dabigatran etexilate mesylate
  • dabigatran etexilate methanesulfonate
A THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation.
  • Molecular weight: 627.75
  • Formula: C34H41N7O5
  • CLOGP: 4.71
  • LIPINSKI: 2
  • HAC: 12
  • HDO: 3
  • TPSA: 151.53
  • ALOGS: -4.68
  • ROTB: 17

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1.80 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 6.83 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Oct. 19, 2010 FDA BOEHRINGER INGELHEIM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastrointestinal haemorrhage 4123.00 15.14 1781 39627 75592 46569062
Ischaemic stroke 2131.43 15.14 729 40679 15993 46628661
Cerebrovascular accident 1351.18 15.14 933 40475 100106 46544548
Haemorrhage 1121.87 15.14 663 40745 54206 46590448
Rectal haemorrhage 949.88 15.14 525 40883 37730 46606924
Melaena 939.96 15.14 469 40939 27303 46617351
Haemorrhage intracranial 850.97 15.14 346 41062 12378 46632276
Cerebral haemorrhage 651.20 15.14 370 41038 28001 46616653
Lower gastrointestinal haemorrhage 626.33 15.14 238 41170 7082 46637572
Activated partial thromboplastin time prolonged 564.33 15.14 217 41191 6672 46637982
Subdural haematoma 417.32 15.14 212 41196 12785 46631869
Cerebral infarction 411.47 15.14 257 41151 23109 46621545
Cardiac tamponade 399.73 15.14 150 41258 4304 46640350
Embolic stroke 368.73 15.14 134 41274 3505 46641149
Shock haemorrhagic 346.65 15.14 164 41244 8460 46636194
Blood loss anaemia 344.80 15.14 163 41245 8394 46636260
Haematoma 341.40 15.14 258 41150 31614 46613040
International normalised ratio increased 325.35 15.14 295 41113 46588 46598066
Haematochezia 314.77 15.14 263 41145 37230 46607424
Coagulopathy 311.93 15.14 198 41210 18301 46626353
Upper gastrointestinal haemorrhage 309.59 15.14 190 41218 16548 46628106
Fall 301.63 15.14 800 40608 328297 46316357
Transient ischaemic attack 274.84 15.14 236 41172 34667 46609987
Haemorrhagic stroke 267.99 15.14 120 41288 5446 46639208
Haematuria 266.96 15.14 208 41200 26650 46618004
Pericardial haemorrhage 250.57 15.14 81 41327 1470 46643184
Atrial thrombosis 235.68 15.14 76 41332 1368 46643286
Anaemia 225.01 15.14 613 40795 255166 46389488
Haematemesis 211.09 15.14 187 41221 28619 46616035
Thrombin time prolonged 205.78 15.14 40 41368 57 46644597
Subarachnoid haemorrhage 204.67 15.14 126 41282 11027 46633627
Intestinal haemorrhage 192.27 15.14 80 41328 3028 46641626
Deep vein thrombosis 191.85 15.14 291 41117 79482 46565172
Pulmonary embolism 175.86 15.14 332 41076 108253 46536401
Acute kidney injury 167.56 15.14 524 40884 235331 46409323
Rheumatoid arthritis 167.03 15.14 12 41396 240203 46404451
Haemoglobin decreased 166.75 15.14 359 41049 128590 46516064
Pain 164.70 15.14 111 41297 476837 46167817
Atrial fibrillation 160.67 15.14 311 41097 103279 46541375
Hemiparesis 158.52 15.14 136 41272 19933 46624721
Hypovolaemic shock 147.50 15.14 78 41330 5105 46639549
Drug hypersensitivity 146.75 15.14 21 41387 243804 46400850
Epistaxis 142.55 15.14 226 41182 64079 46580575
Renal failure 138.57 15.14 309 41099 113285 46531369
Subdural haemorrhage 137.68 15.14 62 41346 2850 46641804
Aortic dissection 122.70 15.14 48 41360 1544 46643110
Creatinine renal clearance decreased 121.44 15.14 76 41332 6844 46637810
Procoagulant therapy 114.55 15.14 19 41389 0 46644654
Cardiac failure 109.50 15.14 228 41180 79720 46564934
Wound secretion 109.30 15.14 58 41350 3822 46640832
Fatigue 104.78 15.14 242 41166 608455 46036199
Hemiplegia 103.98 15.14 69 41339 6869 46637785
Renal impairment 102.90 15.14 213 41195 74159 46570495
Haemothorax 101.79 15.14 45 41363 1979 46642675
Peripheral embolism 101.78 15.14 39 41369 1185 46643469
Prothrombin time prolonged 101.16 15.14 77 41331 9519 46635135
Haemoptysis 98.76 15.14 119 41289 26070 46618584
Procedural haemorrhage 97.77 15.14 46 41362 2340 46642314
Pyrexia 96.97 15.14 100 41308 348702 46295952
Coagulation time prolonged 92.12 15.14 37 41371 1277 46643377
Cerebral haematoma 91.49 15.14 49 41359 3290 46641364
Gastric haemorrhage 88.89 15.14 59 41349 5875 46638779
Head injury 86.51 15.14 108 41300 24528 46620126
Haemorrhoidal haemorrhage 83.84 15.14 48 41360 3672 46640982
Dyspepsia 83.11 15.14 186 41222 68286 46576368
Large intestinal haemorrhage 82.76 15.14 33 41375 1117 46643537
Maternal exposure during pregnancy 77.81 15.14 3 41405 102546 46542108
Toxicity to various agents 77.35 15.14 46 41362 211720 46432934
Post procedural haemorrhage 76.98 15.14 59 41349 7367 46637287
Anxiety 76.21 15.14 33 41375 181924 46462730
Haemorrhagic transformation stroke 75.35 15.14 31 41377 1139 46643515
Faeces discoloured 74.56 15.14 83 41325 16704 46627950
Depression 74.23 15.14 29 41379 170075 46474579
Rash 72.88 15.14 128 41280 356384 46288270
Arthralgia 72.66 15.14 133 41275 364470 46280184
Injection site pain 72.56 15.14 6 41402 107146 46537508
Traumatic haemorrhage 72.48 15.14 23 41385 392 46644262
Nausea 72.04 15.14 340 41068 687114 45957540
Aphasia 69.69 15.14 105 41303 28462 46616192
Drug ineffective 68.24 15.14 340 41068 677498 45967156
Headache 67.15 15.14 210 41198 478142 46166512
Thrombin time abnormal 66.32 15.14 11 41397 0 46644654
Embolism 65.97 15.14 53 41355 7085 46637569
Pericardial effusion 65.34 15.14 96 41312 25447 46619207
International normalised ratio abnormal 65.03 15.14 38 41370 3021 46641633
Mouth haemorrhage 64.75 15.14 50 41358 6312 46638342
Cerebral artery occlusion 63.91 15.14 26 41382 928 46643726
Pulmonary haemorrhage 63.76 15.14 50 41358 6455 46638199
Neutropenia 63.15 15.14 24 41384 143180 46501474
Nasopharyngitis 62.79 15.14 29 41379 153969 46490685
Splenic rupture 61.23 15.14 27 41381 1180 46643474
Product dose omission issue 60.96 15.14 37 41371 168483 46476171
Musculoskeletal stiffness 59.91 15.14 8 41400 97985 46546669
Activated partial thromboplastin time abnormal 58.85 15.14 15 41393 109 46644545
Condition aggravated 58.63 15.14 79 41329 244973 46399681
International normalised ratio 57.82 15.14 14 41394 80 46644574
Gingival bleeding 57.72 15.14 61 41347 11578 46633076
Intestinal ischaemia 56.85 15.14 48 41360 6877 46637777
Thrombosis 56.82 15.14 142 41266 55927 46588727
Cardiac valve replacement complication 56.78 15.14 16 41392 177 46644477
Craniocerebral injury 56.69 15.14 31 41377 2169 46642485
Infusion related reaction 55.75 15.14 11 41397 101197 46543457
Contusion 55.22 15.14 187 41221 87300 46557354
Intra-abdominal haemorrhage 55.03 15.14 31 41377 2299 46642355
Weight increased 54.26 15.14 40 41368 164433 46480221
Hip fracture 54.25 15.14 90 41318 26466 46618188
Drug intolerance 53.58 15.14 32 41376 147017 46497637
Sinusitis 53.57 15.14 24 41384 129744 46514910
Cerebral artery embolism 53.48 15.14 22 41386 808 46643846
Intracardiac thrombus 52.60 15.14 30 41378 2278 46642376
Drug interaction 51.41 15.14 332 41076 202762 46441892
Peripheral ischaemia 51.20 15.14 38 41370 4521 46640133
Puncture site haemorrhage 50.79 15.14 16 41392 266 46644388
Retroperitoneal haemorrhage 50.47 15.14 31 41377 2699 46641955
Iron deficiency anaemia 50.40 15.14 69 41339 17137 46627517
Colon cancer 50.32 15.14 51 41357 9218 46635436
Cerebral ischaemia 50.20 15.14 43 41365 6282 46638372
Therapeutic product effect decreased 49.88 15.14 7 41401 82594 46562060
Blood urine present 48.25 15.14 57 41351 12225 46632429
Back pain 47.94 15.14 70 41338 209969 46434685
Chills 47.80 15.14 13 41395 96019 46548635
Joint swelling 46.73 15.14 47 41361 166026 46478628
Acute abdomen 46.28 15.14 24 41384 1508 46643146
Neuropathy peripheral 43.95 15.14 13 41395 90880 46553774
Anticoagulation drug level increased 43.94 15.14 13 41395 173 46644481
Product use issue 43.17 15.14 15 41393 94629 46550025
Treatment failure 42.04 15.14 15 41393 93072 46551582
Peripheral swelling 41.94 15.14 47 41361 158024 46486630
Gastritis erosive 41.82 15.14 36 41372 5294 46639360
Embolic cerebral infarction 41.82 15.14 16 41392 484 46644170
Hypersensitivity 41.77 15.14 43 41365 150278 46494376
Multiple organ dysfunction syndrome 41.35 15.14 120 41288 51590 46593064
Arthropathy 41.16 15.14 12 41396 84688 46559966
Disease progression 40.74 15.14 15 41393 91285 46553369
Haemarthrosis 40.63 15.14 28 41380 2965 46641689
Shock 40.61 15.14 71 41337 21774 46622880
Haemoperitoneum 40.40 15.14 26 41382 2456 46642198
Traumatic intracranial haemorrhage 40.16 15.14 14 41394 323 46644331
Acute myocardial infarction 40.15 15.14 88 41320 31836 46612818
Peripheral artery thrombosis 39.85 15.14 23 41385 1786 46642868
Drug abuse 39.17 15.14 5 41403 63403 46581251
Haemorrhage subcutaneous 39.01 15.14 27 41381 2879 46641775
Haemorrhagic cerebral infarction 38.84 15.14 16 41392 590 46644064
Systemic lupus erythematosus 38.25 15.14 6 41402 65174 46579480
Strangulated hernia 38.17 15.14 9 41399 45 46644609
Influenza 37.64 15.14 16 41392 89254 46555400
Vaginal haemorrhage 37.35 15.14 75 41333 25529 46619125
Colitis ischaemic 36.49 15.14 45 41363 10087 46634567
Hypocoagulable state 36.29 15.14 18 41390 1029 46643625
Intraventricular haemorrhage 36.16 15.14 22 41386 1883 46642771
Cardiac perforation 35.98 15.14 9 41399 60 46644594
Femoral neck fracture 35.87 15.14 40 41368 8063 46636591
Exsanguination 35.22 15.14 7 41401 12 46644642
Upper respiratory tract infection 34.80 15.14 7 41401 63549 46581105
Infection 34.05 15.14 41 41367 133551 46511103
Coagulation test abnormal 33.88 15.14 15 41393 662 46643992
Prothrombin time abnormal 33.65 15.14 13 41395 404 46644250
White blood cell count decreased 33.62 15.14 30 41378 112201 46532453
Diverticulum intestinal haemorrhagic 33.38 15.14 18 41390 1225 46643429
Ischaemic cerebral infarction 33.35 15.14 18 41390 1227 46643427
Skin haemorrhage 33.06 15.14 33 41375 5858 46638796
Skull fracture 33.01 15.14 16 41392 870 46643784
Diverticulum 32.91 15.14 45 41363 11161 46633493
Contraindicated product administered 32.65 15.14 15 41393 79932 46564722
Prothrombin time shortened 32.58 15.14 20 41388 1739 46642915
Stress 32.00 15.14 4 41404 51547 46593107
Asthma 31.84 15.14 21 41387 91521 46553133
Subcutaneous haematoma 31.71 15.14 19 41389 1582 46643072
Mesenteric artery embolism 31.54 15.14 6 41402 7 46644647
Wound haemorrhage 31.50 15.14 21 41387 2106 46642548
Product use in unapproved indication 31.00 15.14 21 41387 90252 46554402
Hypochromic anaemia 30.96 15.14 18 41390 1417 46643237
Diarrhoea 30.76 15.14 333 41075 559269 46085385
Death 30.69 15.14 442 40966 335106 46309548
Coagulation factor increased 30.30 15.14 6 41402 10 46644644
Pelvic haematoma 30.28 15.14 13 41395 532 46644122
Psoriasis 30.20 15.14 16 41392 78588 46566066
Cough 30.16 15.14 104 41304 230145 46414509
Prothrombin time ratio decreased 29.99 15.14 12 41396 410 46644244
Insomnia 29.46 15.14 64 41344 164860 46479794
Post procedural haematoma 29.29 15.14 17 41391 1334 46643320
Ischaemia 29.01 15.14 27 41381 4397 46640257
Pruritus 28.78 15.14 114 41294 242238 46402416
Small intestinal haemorrhage 28.48 15.14 19 41389 1907 46642747
Constipation 28.34 15.14 71 41337 174026 46470628
Intracranial haematoma 28.17 15.14 11 41397 352 46644302
Paraesthesia 27.90 15.14 38 41370 117399 46527255
Neutrophil count decreased 27.87 15.14 3 41405 43423 46601231
Femoral artery embolism 27.69 15.14 7 41401 49 46644605
Therapeutic response decreased 27.64 15.14 3 41405 43142 46601512
Stomatitis 27.60 15.14 13 41395 68284 46576370
Oesophageal ulcer 27.58 15.14 25 41383 3936 46640718
Brain herniation 26.99 15.14 22 41386 3001 46641653
Gastric ulcer haemorrhage 26.82 15.14 27 41381 4841 46639813
Microcytic anaemia 26.52 15.14 22 41386 3076 46641578
Incarcerated hernia 26.22 15.14 8 41400 119 46644535
Ecchymosis 25.96 15.14 39 41369 10537 46634117
Oesophageal pain 25.91 15.14 20 41388 2523 46642131
Haematocrit decreased 25.78 15.14 79 41329 34978 46609676
Suicidal ideation 25.59 15.14 9 41399 56373 46588281
Phlebitis 25.40 15.14 29 41379 5997 46638657
Anticoagulation drug level above therapeutic 25.22 15.14 15 41393 1232 46643422
Influenza like illness 24.78 15.14 10 41398 57560 46587094
Intentional product use issue 24.70 15.14 8 41400 52772 46591882
Rhinorrhoea 24.58 15.14 6 41402 47659 46596995
Therapeutic product effect incomplete 24.49 15.14 20 41388 78133 46566521
Neurologic neglect syndrome 24.39 15.14 12 41396 674 46643980
Alopecia 24.33 15.14 69 41339 162345 46482309
Pain in extremity 24.03 15.14 133 41275 258547 46386107
Road traffic accident 23.98 15.14 60 41348 23631 46621023
Intentional overdose 23.82 15.14 14 41394 64930 46579724
Vomiting 23.82 15.14 272 41136 452522 46192132
Cardiac failure congestive 23.78 15.14 151 41257 91599 46553055
Intestinal infarction 23.40 15.14 13 41395 938 46643716
Hot flush 23.39 15.14 5 41403 43512 46601142
Swelling 23.33 15.14 47 41361 124464 46520190
Lower respiratory tract infection 23.02 15.14 10 41398 55079 46589575
Atrial flutter 22.84 15.14 34 41374 9114 46635540
Basal ganglia haemorrhage 22.81 15.14 11 41397 591 46644063
Pulmonary alveolar haemorrhage 22.77 15.14 23 41385 4139 46640515
Weight decreased 22.66 15.14 103 41305 210746 46433908
Dysphagia 22.42 15.14 131 41277 77181 46567473
Somnolence 22.35 15.14 68 41340 156453 46488201
Glossodynia 22.08 15.14 6 41402 44367 46600287
Petechiae 22.03 15.14 40 41368 12630 46632024
Occult blood positive 21.90 15.14 21 41387 3549 46641105
Gastritis haemorrhagic 21.85 15.14 14 41394 1312 46643342
Prothrombin time 21.73 15.14 5 41403 22 46644632
Injection site bruising 21.55 15.14 3 41405 35633 46609021
Disseminated intravascular coagulation 21.23 15.14 50 41358 18955 46625699
Conjunctival haemorrhage 21.12 15.14 19 41389 2962 46641692
Occult blood 21.08 15.14 12 41396 908 46643746
Mobility decreased 20.93 15.14 14 41394 60580 46584074
Haemorrhage urinary tract 20.85 15.14 11 41397 716 46643938
Pelvic fracture 20.79 15.14 37 41371 11502 46633152
Gastric ulcer 20.71 15.14 54 41354 21809 46622845
Haemorrhagic arteriovenous malformation 20.69 15.14 7 41401 147 46644507
Brain contusion 20.59 15.14 10 41398 546 46644108
Haemorrhoids 20.55 15.14 49 41359 18728 46625926
Hypoaesthesia 20.50 15.14 47 41361 118822 46525832
Herpes zoster 20.49 15.14 18 41390 67854 46576800
Multiple sclerosis relapse 20.40 15.14 6 41402 42119 46602535
Renal infarct 20.34 15.14 13 41395 1214 46643440
Gastrointestinal necrosis 20.04 15.14 18 41390 2800 46641854
Malignant neoplasm progression 19.87 15.14 17 41391 64909 46579745
Prothrombin level decreased 19.71 15.14 10 41398 600 46644054
Nasal congestion 19.68 15.14 9 41399 48104 46596550
Heart transplant 19.60 15.14 9 41399 433 46644221
Post procedural haematuria 19.54 15.14 5 41403 37 46644617
Musculoskeletal pain 19.53 15.14 20 41388 70108 46574546
Splenic haematoma 19.43 15.14 6 41402 93 46644561
Osteoarthritis 19.27 15.14 16 41392 62009 46582645
Activated partial thromboplastin time 19.11 15.14 4 41404 10 46644644
Bronchitis 19.01 15.14 41 41367 105938 46538716
Thrombotic cerebral infarction 18.71 15.14 6 41402 106 46644548
Lacunar infarction 18.60 15.14 19 41389 3466 46641188
Cardioversion 18.58 15.14 12 41396 1140 46643514
Cardiac failure chronic 18.42 15.14 19 41389 3505 46641149
Haemoglobin abnormal 18.39 15.14 21 41387 4342 46640312
Hypotension 18.37 15.14 299 41109 232290 46412364
Cardiogenic shock 18.19 15.14 43 41365 16341 46628313
Spontaneous haematoma 18.12 15.14 10 41398 712 46643942
Thrombotic stroke 17.98 15.14 9 41399 525 46644129
Muscle spasms 17.92 15.14 53 41355 123060 46521594
Diverticulitis intestinal haemorrhagic 17.87 15.14 6 41402 123 46644531
Gastritis 17.86 15.14 69 41339 34309 46610345
Pancytopenia 17.80 15.14 30 41378 85028 46559626
Abdominal wall haematoma 17.77 15.14 17 41391 2864 46641790
Arteriovenous malformation 17.67 15.14 12 41396 1241 46643413
Aortic thrombosis 17.64 15.14 11 41397 984 46643670
Cardiac ablation 17.61 15.14 12 41396 1247 46643407
Gastric cancer 17.54 15.14 17 41391 2912 46641742
Haemorrhagic disorder 17.50 15.14 10 41398 762 46643892
Acute coronary syndrome 17.47 15.14 32 41376 10172 46634482
Blood glucose increased 17.40 15.14 23 41385 71990 46572664
Malaise 17.38 15.14 199 41209 331033 46313621
Leukopenia 17.38 15.14 21 41387 68322 46576332
Bone pain 17.35 15.14 10 41398 46880 46597774
Abdominal wall haemorrhage 17.31 15.14 6 41402 136 46644518
Rectal perforation 17.15 15.14 8 41400 399 46644255
Cerebellar haemorrhage 17.03 15.14 12 41396 1317 46643337
Urticaria 16.98 15.14 51 41357 117841 46526813
Infarction 16.96 15.14 15 41393 2286 46642368
Brain stem stroke 16.72 15.14 7 41401 269 46644385
Blood pressure increased 16.71 15.14 57 41351 126609 46518045
Hospitalisation 16.62 15.14 19 41389 63366 46581288
Myalgia 16.50 15.14 55 41353 123033 46521621
Oesophagitis 16.45 15.14 37 41371 13614 46631040
Arthritis 16.43 15.14 27 41381 77289 46567365
Mucosal inflammation 16.40 15.14 7 41401 38969 46605685
Arterial haemorrhage 16.39 15.14 13 41395 1705 46642949
Migraine 16.28 15.14 23 41385 70003 46574651
Embolism arterial 16.07 15.14 11 41397 1152 46643502
Tremor 15.97 15.14 51 41357 115588 46529066
Spinal cord haematoma 15.86 15.14 6 41402 176 46644478
Lymphadenopathy 15.80 15.14 5 41403 33483 46611171
Depressed mood 15.68 15.14 5 41403 33314 46611340
Polyp 15.63 15.14 21 41387 5122 46639532
Brain stem haemorrhage 15.42 15.14 9 41399 714 46643940
Agitation 15.21 15.14 16 41392 55399 46589255
Rib fracture 15.16 15.14 44 41364 18910 46625744
NIH stroke scale abnormal 15.15 15.14 3 41405 5 46644649

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastrointestinal haemorrhage 2703.88 14.08 1657 45364 81789 29823668
Ischaemic stroke 2168.80 14.08 852 46169 15423 29890034
Cerebrovascular accident 1529.59 14.08 1168 45853 82309 29823148
Haemorrhage 1057.84 14.08 740 46281 45339 29860118
Haemorrhage intracranial 846.40 14.08 431 46590 14601 29890856
Rectal haemorrhage 810.35 14.08 565 46456 34374 29871083
Cerebral infarction 804.33 14.08 506 46515 25867 29879590
Melaena 697.53 14.08 501 46520 31936 29873521
Cerebral haemorrhage 691.33 14.08 501 46520 32386 29873071
Atrial thrombosis 612.88 14.08 192 46829 1689 29903768
Embolic stroke 586.75 14.08 219 46802 3403 29902054
Subdural haematoma 555.66 14.08 355 46666 18617 29886840
Cardiac tamponade 503.44 14.08 210 46811 4434 29901023
Haematuria 412.74 14.08 426 46595 44408 29861049
Lower gastrointestinal haemorrhage 371.56 14.08 201 46820 7703 29897754
Transient ischaemic attack 368.55 14.08 310 46711 24890 29880567
Fall 367.35 14.08 851 46170 181021 29724436
Activated partial thromboplastin time prolonged 359.46 14.08 196 46825 7632 29897825
Shock haemorrhagic 304.66 14.08 191 46830 9674 29895783
Hemiparesis 291.45 14.08 217 46804 14585 29890872
Upper gastrointestinal haemorrhage 261.94 14.08 241 46780 21787 29883670
Blood loss anaemia 236.32 14.08 148 46873 7479 29897978
Deep vein thrombosis 223.49 14.08 366 46655 60135 29845322
Coagulopathy 211.53 14.08 198 46823 18289 29887168
Pericardial haemorrhage 206.86 14.08 98 46923 2820 29902637
Haemorrhagic stroke 204.96 14.08 125 46896 6022 29899435
Pulmonary embolism 199.88 14.08 403 46618 77732 29827725
Thrombin time prolonged 190.11 14.08 46 46975 128 29905329
Haematoma 187.41 14.08 209 46812 23744 29881713
Subarachnoid haemorrhage 183.62 14.08 140 46881 9746 29895711
Haemothorax 174.44 14.08 93 46928 3456 29902001
Aphasia 164.89 14.08 177 46844 19262 29886195
Aortic dissection 160.90 14.08 78 46943 2364 29903093
Toxicity to various agents 142.90 14.08 50 46971 177133 29728324
Epistaxis 139.83 14.08 277 46744 52704 29852753
Completed suicide 137.78 14.08 4 47017 99488 29805969
Head injury 133.95 14.08 149 46872 16871 29888586
Haematemesis 133.00 14.08 184 46837 26019 29879438
Pyrexia 132.45 14.08 161 46860 294328 29611129
Haematochezia 127.54 14.08 208 46813 34014 29871443
Hemiplegia 127.38 14.08 96 46925 6565 29898892
Procoagulant therapy 127.31 14.08 24 46997 4 29905453
Procedural haemorrhage 125.53 14.08 65 46956 2273 29903184
Haemorrhagic transformation stroke 124.89 14.08 53 46968 1168 29904289
Febrile neutropenia 121.52 14.08 13 47008 106680 29798777
Neutropenia 118.81 14.08 28 46993 128512 29776945
Haemoptysis 118.68 14.08 191 46830 30887 29874570
Subdural haemorrhage 110.33 14.08 64 46957 2808 29902649
Anaemia 108.92 14.08 626 46395 207366 29698091
Intracardiac thrombus 108.76 14.08 60 46961 2388 29903069
Intestinal haemorrhage 103.91 14.08 64 46957 3137 29902320
Cerebral haematoma 102.06 14.08 72 46949 4442 29901015
Peripheral embolism 99.63 14.08 41 46980 834 29904623
Post procedural haemorrhage 94.85 14.08 87 46934 7823 29897634
Brain contusion 93.49 14.08 38 46983 748 29904709
International normalised ratio increased 92.09 14.08 220 46801 47519 29857938
Pericardial effusion 90.53 14.08 137 46884 21007 29884450
Cardiac failure 87.57 14.08 309 46712 83109 29822348
Colon cancer 86.87 14.08 85 46936 8287 29897170
Product dose omission issue 86.55 14.08 19 47002 91612 29813845
Drug abuse 86.17 14.08 13 47008 82059 29823398
Fatigue 84.15 14.08 243 46778 320430 29585027
Oesophageal pain 81.01 14.08 34 46987 728 29904729
Large intestinal haemorrhage 76.78 14.08 41 46980 1528 29903929
Renal impairment 72.72 14.08 293 46728 83891 29821566
Anticoagulation drug level increased 71.76 14.08 28 46993 493 29904964
Disease progression 70.66 14.08 19 47002 79855 29825602
Faeces discoloured 69.34 14.08 97 46924 13849 29891608
Depression 68.66 14.08 28 46993 90409 29815048
Pancytopenia 68.46 14.08 24 46997 85028 29820429
Pain 67.71 14.08 104 46917 172537 29732920
Pulmonary haemorrhage 66.72 14.08 78 46943 9314 29896143
Gastric haemorrhage 66.22 14.08 78 46943 9389 29896068
Traumatic intracranial haemorrhage 66.06 14.08 28 46993 615 29904842
Blood urine present 65.03 14.08 79 46942 9821 29895636
Dyspepsia 64.19 14.08 145 46876 30184 29875273
Road traffic accident 63.89 14.08 104 46917 16967 29888490
Extradural haematoma 63.67 14.08 33 46988 1156 29904301
Nausea 63.45 14.08 246 46775 296711 29608746
Embolism 63.27 14.08 66 46955 6943 29898514
Diarrhoea 63.24 14.08 290 46731 333813 29571644
Drug hypersensitivity 63.11 14.08 15 47006 68504 29836953
Rash 61.46 14.08 131 46890 191758 29713699
Contusion 61.21 14.08 145 46876 31135 29874322
Cerebral artery occlusion 61.14 14.08 28 46993 744 29904713
Coagulation test abnormal 61.12 14.08 24 46997 430 29905027
Leukopenia 61.03 14.08 8 47013 56151 29849306
Gingival bleeding 60.87 14.08 62 46959 6342 29899115
Hypovolaemic shock 60.10 14.08 62 46959 6438 29899019
Product use in unapproved indication 58.95 14.08 21 47000 73672 29831785
Urinary bladder haemorrhage 58.71 14.08 35 46986 1616 29903841
White blood cell count decreased 57.50 14.08 30 46991 83917 29821540
Wound secretion 56.69 14.08 40 46981 2468 29902989
Intraventricular haemorrhage 56.44 14.08 43 46978 2987 29902470
Splenic rupture 55.76 14.08 33 46988 1503 29903954
Tremor 54.54 14.08 25 46996 75338 29830119
Coagulation time prolonged 54.14 14.08 30 46991 1204 29904253
Haemorrhagic infarction 54.01 14.08 21 47000 366 29905091
Skull fracture 53.27 14.08 27 46994 902 29904555
Insomnia 52.16 14.08 42 46979 93294 29812163
Embolic cerebral infarction 51.11 14.08 24 46997 676 29904781
Anorectal discomfort 50.66 14.08 33 46988 1784 29903673
Chills 49.31 14.08 26 46995 72312 29833145
Cardiac ablation 48.51 14.08 22 46999 571 29904886
Anxiety 47.10 14.08 43 46978 89828 29815629
Embolism arterial 46.92 14.08 21 47000 528 29904929
Rheumatoid arthritis 46.91 14.08 5 47016 41192 29864265
Traumatic haemorrhage 46.75 14.08 22 46999 623 29904834
Activated partial thromboplastin time abnormal 46.07 14.08 13 47008 76 29905381
Creatinine renal clearance decreased 45.99 14.08 40 46981 3353 29902104
Vomiting 45.65 14.08 184 46837 219634 29685823
Cerebral artery embolism 45.05 14.08 24 46997 890 29904567
Thrombosis 44.74 14.08 157 46864 42074 29863383
Aortic aneurysm rupture 44.32 14.08 25 46996 1039 29904418
Agitation 43.94 14.08 15 47006 54058 29851399
Infusion related reaction 43.54 14.08 6 47015 40558 29864899
Condition aggravated 43.37 14.08 95 46926 137771 29767686
Neuropathy peripheral 42.88 14.08 29 46992 70446 29835011
Traumatic haemothorax 41.14 14.08 15 47006 217 29905240
Haemoglobin decreased 40.45 14.08 312 46709 113786 29791671
Haemorrhoidal haemorrhage 40.42 14.08 36 46985 3114 29902343
Surgery 40.04 14.08 68 46953 11483 29893974
Atrial fibrillation 39.64 14.08 298 46723 107826 29797631
Weight increased 39.06 14.08 36 46985 74877 29830580
Renal failure 38.92 14.08 340 46681 128626 29776831
Basal ganglia haemorrhage 37.92 14.08 21 47000 842 29904615
Seizure 37.90 14.08 60 46961 98415 29807042
Psoriasis 37.78 14.08 10 47011 42496 29862961
Renal infarct 37.73 14.08 23 46998 1106 29904351
Neutrophil count decreased 37.71 14.08 10 47011 42444 29863013
Intra-abdominal haemorrhage 37.34 14.08 29 46992 2073 29903384
International normalised ratio 37.25 14.08 10 47011 47 29905410
Alanine aminotransferase increased 37.20 14.08 37 46984 74239 29831218
Acute abdomen 37.17 14.08 27 46994 1744 29903713
Incarcerated hernia 36.78 14.08 13 47008 171 29905286
Muscle spasms 36.43 14.08 29 46992 64809 29840648
Somnolence 36.26 14.08 60 46961 96703 29808754
Mouth haemorrhage 36.19 14.08 42 46979 4975 29900482
Aggression 36.17 14.08 7 47014 36900 29868557
Blood creatine phosphokinase increased 35.91 14.08 12 47009 43836 29861621
Heart transplant 35.62 14.08 17 47004 497 29904960
Cerebellar haemorrhage 35.52 14.08 24 46997 1380 29904077
Arthralgia 35.38 14.08 103 46918 135688 29769769
Oesophageal ulcer 35.36 14.08 34 46987 3243 29902214
Product use issue 35.30 14.08 14 47007 46002 29859455
Malignant neoplasm progression 35.08 14.08 37 46984 72250 29833207
Retroperitoneal haemorrhage 34.78 14.08 31 46990 2684 29902773
Pulmonary alveolar haemorrhage 34.55 14.08 47 46974 6534 29898923
Platelet count decreased 34.30 14.08 72 46949 106057 29799400
Haemorrhage urinary tract 34.02 14.08 25 46996 1644 29903813
Mucosal inflammation 33.96 14.08 4 47017 30490 29874967
Intentional product use issue 33.49 14.08 8 47013 36432 29869025
Cardiac valve replacement complication 33.24 14.08 9 47012 44 29905413
Arterial thrombosis 33.12 14.08 23 46998 1383 29904074
Erythema 32.93 14.08 44 46977 77407 29828050
Dysarthria 32.84 14.08 114 46907 30376 29875081
Thrombin time abnormal 32.75 14.08 6 47015 0 29905457
Activated partial thromboplastin time 32.75 14.08 6 47015 0 29905457
Creatinine renal clearance 32.75 14.08 6 47015 0 29905457
International normalised ratio abnormal 32.74 14.08 32 46989 3114 29902343
Femoral neck fracture 32.65 14.08 31 46990 2911 29902546
Strangulated hernia 32.44 14.08 7 47014 9 29905448
Gastrointestinal carcinoma 32.40 14.08 20 47001 984 29904473
Oesophageal carcinoma 32.27 14.08 32 46989 3169 29902288
Coagulation time shortened 31.41 14.08 12 47009 199 29905258
Acute kidney injury 31.26 14.08 603 46418 273239 29632218
Appendicitis 30.93 14.08 43 46978 6101 29899356
Intracranial haematoma 30.40 14.08 14 47007 377 29905080
Weight decreased 30.24 14.08 128 46893 150793 29754664
Wound haemorrhage 30.20 14.08 24 46997 1774 29903683
Cough 30.10 14.08 99 46922 125543 29779914
Gastric cancer 30.10 14.08 38 46983 4912 29900545
Cardioversion 29.86 14.08 18 47003 848 29904609
Drug intolerance 29.81 14.08 17 47004 45274 29860183
Large intestine polyp 29.45 14.08 44 46977 6665 29898792
Neurologic neglect syndrome 29.44 14.08 11 47010 171 29905286
Gastrointestinal motility disorder 29.43 14.08 26 46995 2225 29903232
Blood glucose increased 29.29 14.08 32 46989 61498 29843959
Stomatitis 29.16 14.08 11 47010 37268 29868189
C-reactive protein increased 29.07 14.08 16 47005 43457 29862000
White blood cell count increased 28.94 14.08 13 47008 39660 29865797
Hemianopia 28.70 14.08 16 47005 650 29904807
Elderly 28.60 14.08 6 47015 6 29905451
Urogenital haemorrhage 28.54 14.08 11 47010 187 29905270
Cardiac perforation 28.53 14.08 9 47012 81 29905376
Aspartate aminotransferase increased 28.02 14.08 35 46986 63387 29842070
Ischaemia 27.95 14.08 35 46986 4486 29900971
Multiple injuries 27.89 14.08 24 46997 1983 29903474
Iron deficiency anaemia 27.24 14.08 50 46971 8974 29896483
Post procedural stroke 27.19 14.08 7 47014 27 29905430
Plasma cell myeloma 26.34 14.08 27 46994 53435 29852022
Asthma 26.16 14.08 12 47009 36162 29869295
Craniocerebral injury 26.15 14.08 27 46994 2806 29902651
Anaphylactic reaction 26.00 14.08 6 47015 27976 29877481
Rib fracture 26.00 14.08 60 46961 12660 29892797
Infarction 25.98 14.08 26 46995 2604 29902853
Peripheral artery thrombosis 25.69 14.08 24 46997 2208 29903249
Haemorrhage subcutaneous 25.64 14.08 24 46997 2213 29903244
Off label use 25.63 14.08 259 46762 249031 29656426
Cerebellar infarction 25.47 14.08 22 46999 1827 29903630
Nasopharyngitis 25.45 14.08 33 46988 58816 29846641
Acute myocardial infarction 25.40 14.08 156 46865 52783 29852674
Injection site pain 25.34 14.08 8 47013 30302 29875155
Therapeutic response decreased 25.21 14.08 4 47017 24345 29881112
Rhabdomyolysis 25.16 14.08 38 46983 63542 29841915
Joint swelling 25.13 14.08 22 46999 46924 29858533
Diverticulum intestinal haemorrhagic 25.03 14.08 23 46998 2072 29903385
Exsanguination 24.94 14.08 7 47014 40 29905417
Prothrombin time prolonged 24.93 14.08 49 46972 9254 29896203
Thrombotic stroke 24.82 14.08 11 47010 270 29905187
Abnormal behaviour 24.81 14.08 5 47016 25618 29879839
Ecchymosis 24.76 14.08 40 46981 6482 29898975
Intestinal ischaemia 24.43 14.08 41 46980 6856 29898601
Arteriovenous malformation 24.36 14.08 14 47007 603 29904854
Infection 24.35 14.08 54 46967 78020 29827437
Electrocardiogram QT prolonged 24.23 14.08 13 47008 35822 29869635
Sinusitis 24.21 14.08 11 47010 33334 29872123
Femur fracture 23.98 14.08 42 46979 7267 29898190
Hyperhidrosis 23.84 14.08 43 46978 67047 29838410
Skin haemorrhage 23.49 14.08 28 46993 3412 29902045
Thrombocytopenia 23.46 14.08 123 46898 136921 29768536
Irritability 23.39 14.08 4 47017 23046 29882411
Feeling abnormal 23.36 14.08 33 46988 56723 29848734
Pulmonary contusion 23.03 14.08 7 47014 55 29905402
Ascites 22.90 14.08 14 47007 35907 29869550
Back pain 22.44 14.08 84 46937 102512 29802945
Hemianopia homonymous 22.31 14.08 14 47007 709 29904748
Colon neoplasm 22.16 14.08 11 47010 351 29905106
Cerebral ischaemia 22.15 14.08 37 46984 6163 29899294
Cholecystitis acute 22.11 14.08 34 46987 5283 29900174
Mesenteric artery embolism 22.09 14.08 7 47014 64 29905393
Diabetes mellitus 21.95 14.08 20 47001 41845 29863612
Cerebral vascular occlusion 21.83 14.08 4 47017 0 29905457
Dyskinesia 21.69 14.08 4 47017 21830 29883627
Aneurysm ruptured 21.65 14.08 12 47009 482 29904975
Herpes zoster 21.54 14.08 10 47011 29933 29875524
Musculoskeletal stiffness 21.50 14.08 15 47006 35866 29869591
Ischaemic cerebral infarction 21.42 14.08 15 47006 914 29904543
Gastrointestinal angiodysplasia 21.38 14.08 12 47009 494 29904963
Subarachnoid haematoma 21.27 14.08 7 47014 73 29905384
Thalamus haemorrhage 21.01 14.08 15 47006 943 29904514
Influenza like illness 20.97 14.08 7 47014 25598 29879859
Renal haemorrhage 20.91 14.08 17 47004 1298 29904159
Subcutaneous haematoma 20.87 14.08 15 47006 953 29904504
Myalgia 20.80 14.08 57 46964 76610 29828847
Pneumonia 20.75 14.08 385 46636 333921 29571536
Vision blurred 20.73 14.08 21 47000 41795 29863662
Gastric ulcer haemorrhage 20.73 14.08 33 46988 5281 29900176
Hyperglycaemia 20.72 14.08 15 47006 35185 29870272
Lumbar puncture 20.62 14.08 7 47014 81 29905376
Haemoglobin abnormal 20.60 14.08 25 46996 3104 29902353
Haemorrhoids 20.28 14.08 53 46968 12088 29893369
Brain herniation 20.07 14.08 27 46994 3713 29901744
Productive cough 20.06 14.08 11 47010 29942 29875515
Hospitalisation 20.05 14.08 24 46997 44295 29861162
Coronary artery embolism 19.94 14.08 8 47013 152 29905305
Venous thrombosis 19.94 14.08 25 46996 3209 29902248
Hypertension 19.62 14.08 111 46910 121243 29784214
Stress 19.49 14.08 4 47017 20231 29885226
Osteonecrosis of jaw 19.41 14.08 3 47018 18615 29886842
Urticaria 19.40 14.08 35 46986 54571 29850886
Haemoperitoneum 19.31 14.08 17 47004 1448 29904009
Factor V deficiency 19.28 14.08 5 47016 20 29905437
Memory impairment 19.20 14.08 18 47003 37156 29868301
Occult blood 18.96 14.08 9 47012 260 29905197
Haemodynamic instability 18.85 14.08 40 46981 7975 29897482
Catheter site haemorrhage 18.80 14.08 20 47001 2152 29903305
Rectal cancer 18.76 14.08 20 47001 2156 29903301
Hallucination 18.76 14.08 30 46991 49029 29856428
Colitis ischaemic 18.66 14.08 33 46988 5753 29899704
Angioedema 18.54 14.08 16 47005 34368 29871089
Pneumonitis 18.50 14.08 10 47011 27444 29878013
Gastric ulcer 18.47 14.08 59 46962 15062 29890395
Mesenteric haemorrhage 18.18 14.08 4 47017 6 29905451
Abdominal discomfort 18.14 14.08 135 46886 48656 29856801
Arterial injury 18.14 14.08 9 47012 287 29905170
Oxygen saturation decreased 18.13 14.08 25 46996 43415 29862042
Traumatic haematoma 17.87 14.08 12 47009 683 29904774
Cardiac pacemaker insertion 17.85 14.08 21 47000 2524 29902933
Intestinal infarction 17.73 14.08 11 47010 546 29904911
Intentional product misuse 17.66 14.08 17 47004 34650 29870807
Peripheral swelling 17.64 14.08 44 46977 61030 29844427
Splenic injury 17.47 14.08 5 47016 31 29905426
Aortic aneurysm 17.45 14.08 34 46987 6379 29899078
Confusional state 17.40 14.08 132 46889 134702 29770755
Hypersensitivity 17.15 14.08 37 46984 53991 29851466
Orthopaedic procedure 17.13 14.08 4 47017 9 29905448
Blood cholesterol increased 17.10 14.08 3 47018 16967 29888490
Occult blood positive 16.99 14.08 25 46996 3735 29901722
Drug reaction with eosinophilia and systemic symptoms 16.95 14.08 12 47009 28476 29876981
Dry skin 16.94 14.08 7 47014 22447 29883010
Puncture site haemorrhage 16.91 14.08 9 47012 333 29905124
Internal haemorrhage 16.62 14.08 27 46994 4395 29901062
Prothrombin time shortened 16.53 14.08 16 47005 1539 29903918
Gait disturbance 16.49 14.08 61 46960 74716 29830741
Monoparesis 16.42 14.08 15 47006 1341 29904116
Inguinal hernia strangulated 16.38 14.08 3 47018 0 29905457
Diverticulum 16.30 14.08 34 46987 6699 29898758
Diverticulitis intestinal haemorrhagic 16.27 14.08 9 47012 360 29905097
Incarcerated inguinal hernia 16.26 14.08 6 47015 90 29905367
Blood lactate dehydrogenase increased 16.24 14.08 6 47015 20595 29884862
Small intestinal haemorrhage 16.02 14.08 18 47003 2058 29903399
Lymphocyte count decreased 15.98 14.08 5 47016 19050 29886407
Injury 15.91 14.08 72 46949 21659 29883798
Aortic dissection rupture 15.84 14.08 4 47017 14 29905443
Eye haemorrhage 15.83 14.08 24 46997 3683 29901774
Pain in extremity 15.63 14.08 105 46916 110116 29795341
Pruritus 15.59 14.08 115 46906 118089 29787368
Gastritis erosive 15.57 14.08 30 46991 5583 29899874
Therapy non-responder 15.52 14.08 14 47007 29439 29876018
Hypokalaemia 15.41 14.08 35 46986 50157 29855300
Peripheral ischaemia 15.40 14.08 29 46992 5305 29900152
Microvillous inclusion disease 15.38 14.08 5 47016 50 29905407
Hyponatraemia 15.36 14.08 54 46967 67148 29838309
Conjunctival haemorrhage 15.27 14.08 20 47001 2680 29902777
Intentional overdose 15.26 14.08 26 46995 41455 29864002
Pneumocystis jirovecii pneumonia 15.26 14.08 4 47017 17116 29888341
Influenza 15.25 14.08 28 46993 43370 29862087
Tachycardia 15.08 14.08 62 46959 73677 29831780
Encephalopathy 15.04 14.08 17 47004 32188 29873269
Thrombotic cerebral infarction 15.01 14.08 8 47013 297 29905160
Post procedural pulmonary embolism 14.87 14.08 4 47017 19 29905438
Drug ineffective 14.86 14.08 414 46607 339973 29565484
Skin laceration 14.76 14.08 45 46976 11206 29894251
Cataract 14.65 14.08 8 47013 21827 29883630
Thoracic haemorrhage 14.50 14.08 7 47014 210 29905247
Muscle strain 14.47 14.08 23 46998 3676 29901781
Serotonin syndrome 14.46 14.08 5 47016 17886 29887571
Duodenitis 14.29 14.08 24 46997 4016 29901441
Oesophageal injury 14.23 14.08 4 47017 23 29905434
Hip fracture 14.13 14.08 44 46977 11080 29894377
Mechanical ileus 14.11 14.08 7 47014 223 29905234

Pharmacologic Action:

SourceCodeDescription
ATC B01AE07 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Direct thrombin inhibitors
MeSH PA D000925 Anticoagulants
MeSH PA D000991 Antithrombins
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D006401 Hematologic Agents
MeSH PA D011480 Protease Inhibitors
MeSH PA D015842 Serine Proteinase Inhibitors
CHEBI has role CHEBI:50249 anticoagulante
CHEBI has role CHEBI:50266 prodrugs
CHEBI has role CHEBI:65232 ec 3.4.21.5 inhibitor
CHEBI has role CHEBI:77020 nrh:quinone oxidoreductase 2 inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Prevention of deep vein thrombosis indication 439993001
Prevention of Thromboembolism with Chronic Atrial Fibrillation indication
Acute hemorrhage contraindication 8573003
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Anemia contraindication 271737000 DOID:2355
Cerebral hemorrhage contraindication 274100004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.35 Basic
pKa2 2.31 Basic
pKa3 1.61 Basic
pKa4 0.55 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prothrombin Enzyme INHIBITOR Ki 8.35 CHEMBL CHEMBL
Trypsin Enzyme Ki 7.30 CHEMBL
Plasminogen Enzyme Ki 5.77 CHEMBL
Coagulation factor X Enzyme Ki 5.42 CHEMBL
Solute carrier family 22 member 2 Transporter IC50 5.33 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 5.09 CHEMBL
Ribosyldihydronicotinamide dehydrogenase [quinone] Enzyme IC50 4.96 CHEMBL
Vitamin K-dependent protein C Enzyme Ki 4.68 CHEMBL
Multidrug and toxin extrusion protein 2 Transporter IC50 4.60 CHEMBL
Serine protease hepsin Enzyme Ki 6.08 CHEMBL
Tissue-type plasminogen activator Enzyme Ki 4.34 CHEMBL

External reference:

IDSource
4030255 VUID
N0000181837 NUI
D07082 KEGG_DRUG
872728-81-9 SECONDARY_CAS_RN
211914-51-1 SECONDARY_CAS_RN
4030254 VANDF
4030255 VANDF
C1122231 UMLSCUI
C2348066 UMLSCUI
CHEBI:70746 CHEBI
CHEBI:70752 CHEBI
CHEMBL539697 ChEMBL_ID
CHEMBL1615369 ChEMBL_ID
CHEMBL48361 ChEMBL_ID
DB06695 DRUGBANK_ID
D000069604 MESH_DESCRIPTOR_UI
135565674 PUBCHEM_CID
6379 IUPHAR_LIGAND_ID
8028 INN_ID
8027 INN_ID
2E18WX195X UNII
I0VM4M70GC UNII
216210 PUBCHEM_CID
6380 IUPHAR_LIGAND_ID
DB14726 DRUGBANK_ID
1037041 RXNORM
136711 MMSL
25762 MMSL
d07137 MMSL
012668 NDDF
012669 NDDF
698871007 SNOMEDCT_US
700029008 SNOMEDCT_US
700039002 SNOMEDCT_US
714788005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Pradaxa HUMAN PRESCRIPTION DRUG LABEL 1 0597-0108 CAPSULE 110 mg ORAL NDA 32 sections
Pradaxa HUMAN PRESCRIPTION DRUG LABEL 1 0597-0355 CAPSULE 75 mg ORAL NDA 32 sections
Pradaxa HUMAN PRESCRIPTION DRUG LABEL 1 0597-0360 CAPSULE 150 mg ORAL NDA 32 sections
PRADAXA HUMAN PRESCRIPTION DRUG LABEL 1 21695-899 CAPSULE 150 mg ORAL NDA 27 sections
Pradaxa HUMAN PRESCRIPTION DRUG LABEL 1 50090-3617 CAPSULE 150 mg ORAL NDA 32 sections
Pradaxa HUMAN PRESCRIPTION DRUG LABEL 1 50090-4480 CAPSULE 150 mg ORAL NDA 31 sections
Pradaxa HUMAN PRESCRIPTION DRUG LABEL 1 63629-8242 CAPSULE 150 mg ORAL NDA 27 sections