Stem definition | Drug id | CAS RN |
---|---|---|
thrombin inhibitors, antithrombotic agents | 776 | 211915-06-9 |
Dose | Unit | Route |
---|---|---|
0.30 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 1.80 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 6.83 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
Oct. 19, 2010 | FDA | BOEHRINGER INGELHEIM |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Gastrointestinal haemorrhage | 4291.33 | 14.69 | 1799 | 40976 | 78531 | 53227760 |
Ischaemic stroke | 2230.07 | 14.69 | 749 | 42026 | 17244 | 53289047 |
Cerebrovascular accident | 1465.85 | 14.69 | 959 | 41816 | 104215 | 53202076 |
Haemorrhage | 1184.72 | 14.69 | 676 | 42099 | 57311 | 53248980 |
Melaena | 999.86 | 14.69 | 481 | 42294 | 28648 | 53277643 |
Rectal haemorrhage | 976.27 | 14.69 | 531 | 42244 | 40950 | 53265341 |
Haemorrhage intracranial | 893.06 | 14.69 | 353 | 42422 | 12999 | 53293292 |
Cerebral haemorrhage | 702.66 | 14.69 | 383 | 42392 | 29613 | 53276678 |
Lower gastrointestinal haemorrhage | 653.08 | 14.69 | 241 | 42534 | 7325 | 53298966 |
Activated partial thromboplastin time prolonged | 591.45 | 14.69 | 220 | 42555 | 6839 | 53299452 |
Cardiac tamponade | 469.93 | 14.69 | 166 | 42609 | 4434 | 53301857 |
Subdural haematoma | 440.19 | 14.69 | 217 | 42558 | 13596 | 53292695 |
Cerebral infarction | 437.62 | 14.69 | 262 | 42513 | 24182 | 53282109 |
Embolic stroke | 391.51 | 14.69 | 138 | 42637 | 3661 | 53302630 |
Blood loss anaemia | 365.19 | 14.69 | 166 | 42609 | 8657 | 53297634 |
Shock haemorrhagic | 365.09 | 14.69 | 168 | 42607 | 9015 | 53297276 |
Haematoma | 362.14 | 14.69 | 263 | 42512 | 33581 | 53272710 |
International normalised ratio increased | 354.58 | 14.69 | 299 | 42476 | 47462 | 53258829 |
Fall | 336.86 | 14.69 | 826 | 41949 | 357614 | 52948677 |
Coagulopathy | 334.14 | 14.69 | 204 | 42571 | 19494 | 53286797 |
Upper gastrointestinal haemorrhage | 333.32 | 14.69 | 195 | 42580 | 17235 | 53289056 |
Haematochezia | 322.29 | 14.69 | 269 | 42506 | 42089 | 53264202 |
Transient ischaemic attack | 305.74 | 14.69 | 243 | 42532 | 35482 | 53270809 |
Haematuria | 288.74 | 14.69 | 214 | 42561 | 28175 | 53278116 |
Haemorrhagic stroke | 285.53 | 14.69 | 123 | 42652 | 5635 | 53300656 |
Pericardial haemorrhage | 261.15 | 14.69 | 82 | 42693 | 1501 | 53304790 |
Procoagulant therapy | 251.33 | 14.69 | 41 | 42734 | 0 | 53306291 |
Anaemia | 249.21 | 14.69 | 628 | 42147 | 276090 | 53030201 |
Atrial thrombosis | 243.58 | 14.69 | 77 | 42698 | 1442 | 53304849 |
Haematemesis | 226.48 | 14.69 | 192 | 42583 | 30665 | 53275626 |
Thrombin time prolonged | 223.25 | 14.69 | 43 | 42732 | 67 | 53306224 |
Subarachnoid haemorrhage | 221.95 | 14.69 | 131 | 42644 | 11762 | 53294529 |
Deep vein thrombosis | 213.16 | 14.69 | 296 | 42479 | 82617 | 53223674 |
Pain | 201.70 | 14.69 | 111 | 42664 | 588287 | 52718004 |
Rheumatoid arthritis | 198.38 | 14.69 | 14 | 42761 | 314517 | 52991774 |
Pulmonary embolism | 197.81 | 14.69 | 340 | 42435 | 114102 | 53192189 |
Intestinal haemorrhage | 195.60 | 14.69 | 81 | 42694 | 3359 | 53302932 |
Acute kidney injury | 189.78 | 14.69 | 538 | 42237 | 253330 | 53052961 |
Haemoglobin decreased | 186.96 | 14.69 | 368 | 42407 | 136939 | 53169352 |
Atrial fibrillation | 179.05 | 14.69 | 321 | 42454 | 111331 | 53194960 |
Hemiparesis | 168.69 | 14.69 | 139 | 42636 | 21336 | 53284955 |
Renal failure | 167.95 | 14.69 | 323 | 42452 | 118129 | 53188162 |
Epistaxis | 157.02 | 14.69 | 232 | 42543 | 68478 | 53237813 |
Hypovolaemic shock | 155.01 | 14.69 | 80 | 42695 | 5517 | 53300774 |
Subdural haemorrhage | 144.93 | 14.69 | 63 | 42712 | 2949 | 53303342 |
Drug hypersensitivity | 143.48 | 14.69 | 21 | 42754 | 265221 | 53041070 |
Aortic dissection | 134.54 | 14.69 | 51 | 42724 | 1669 | 53304622 |
Cardiac failure | 131.45 | 14.69 | 242 | 42533 | 85602 | 53220689 |
Fatigue | 128.55 | 14.69 | 245 | 42530 | 730261 | 52576030 |
Renal impairment | 111.69 | 14.69 | 222 | 42553 | 83096 | 53223195 |
Wound secretion | 109.93 | 14.69 | 58 | 42717 | 4185 | 53302106 |
Prothrombin time prolonged | 108.79 | 14.69 | 78 | 42697 | 9744 | 53296547 |
Cerebral haematoma | 108.32 | 14.69 | 54 | 42721 | 3460 | 53302831 |
Haemoptysis | 106.94 | 14.69 | 122 | 42653 | 27917 | 53278374 |
Hemiplegia | 105.37 | 14.69 | 70 | 42705 | 7730 | 53298561 |
Haemothorax | 104.27 | 14.69 | 45 | 42730 | 2069 | 53304222 |
Maternal exposure during pregnancy | 103.87 | 14.69 | 5 | 42770 | 155634 | 53150657 |
Peripheral embolism | 103.76 | 14.69 | 39 | 42736 | 1246 | 53305045 |
Creatinine renal clearance decreased | 103.13 | 14.69 | 78 | 42697 | 10573 | 53295718 |
Procedural haemorrhage | 102.08 | 14.69 | 47 | 42728 | 2522 | 53303769 |
Pyrexia | 101.90 | 14.69 | 104 | 42671 | 403089 | 52903202 |
Head injury | 101.24 | 14.69 | 114 | 42661 | 25719 | 53280572 |
Coagulation time prolonged | 99.04 | 14.69 | 38 | 42737 | 1286 | 53305005 |
Rash | 98.81 | 14.69 | 128 | 42647 | 446063 | 52860228 |
Gastric haemorrhage | 94.53 | 14.69 | 60 | 42715 | 6131 | 53300160 |
Infusion related reaction | 89.94 | 14.69 | 10 | 42765 | 155947 | 53150344 |
Large intestinal haemorrhage | 86.68 | 14.69 | 34 | 42741 | 1222 | 53305069 |
Arthralgia | 85.70 | 14.69 | 138 | 42637 | 439645 | 52866646 |
Haemorrhoidal haemorrhage | 85.36 | 14.69 | 48 | 42727 | 3930 | 53302361 |
Faeces discoloured | 85.06 | 14.69 | 87 | 42688 | 17599 | 53288692 |
Drug ineffective | 83.74 | 14.69 | 355 | 42420 | 816890 | 52489401 |
Dyspepsia | 82.29 | 14.69 | 188 | 42587 | 77412 | 53228879 |
Post procedural haemorrhage | 80.81 | 14.69 | 60 | 42715 | 7908 | 53298383 |
Systemic lupus erythematosus | 80.66 | 14.69 | 5 | 42770 | 125409 | 53180882 |
Traumatic haemorrhage | 78.93 | 14.69 | 25 | 42750 | 471 | 53305820 |
Drug intolerance | 78.90 | 14.69 | 33 | 42742 | 205460 | 53100831 |
Aphasia | 77.68 | 14.69 | 109 | 42666 | 30669 | 53275622 |
Haemorrhagic transformation stroke | 77.67 | 14.69 | 31 | 42744 | 1167 | 53305124 |
Nasopharyngitis | 75.25 | 14.69 | 30 | 42745 | 192265 | 53114026 |
Joint swelling | 74.80 | 14.69 | 48 | 42727 | 234590 | 53071701 |
Anxiety | 73.28 | 14.69 | 33 | 42742 | 196671 | 53109620 |
Therapeutic product effect decreased | 72.59 | 14.69 | 8 | 42767 | 125647 | 53180644 |
Pericardial effusion | 72.43 | 14.69 | 99 | 42676 | 27179 | 53279112 |
Arthropathy | 72.38 | 14.69 | 13 | 42762 | 141440 | 53164851 |
Embolism | 70.55 | 14.69 | 54 | 42721 | 7449 | 53298842 |
Sinusitis | 69.82 | 14.69 | 24 | 42751 | 168540 | 53137751 |
Cerebral artery occlusion | 69.08 | 14.69 | 27 | 42748 | 961 | 53305330 |
Injection site pain | 68.69 | 14.69 | 6 | 42769 | 113385 | 53192906 |
Musculoskeletal stiffness | 68.44 | 14.69 | 9 | 42766 | 123359 | 53182932 |
International normalised ratio abnormal | 68.16 | 14.69 | 38 | 42737 | 3059 | 53303232 |
Condition aggravated | 68.01 | 14.69 | 83 | 42692 | 297051 | 53009240 |
Pulmonary haemorrhage | 67.62 | 14.69 | 51 | 42724 | 6882 | 53299409 |
Mouth haemorrhage | 67.43 | 14.69 | 50 | 42725 | 6576 | 53299715 |
Hypersensitivity | 67.27 | 14.69 | 43 | 42732 | 210622 | 53095669 |
Headache | 66.73 | 14.69 | 215 | 42560 | 536606 | 52769685 |
Depression | 66.18 | 14.69 | 32 | 42743 | 183020 | 53123271 |
Gingival bleeding | 65.55 | 14.69 | 64 | 42711 | 12244 | 53294047 |
Splenic rupture | 65.05 | 14.69 | 28 | 42747 | 1279 | 53305012 |
Weight increased | 64.98 | 14.69 | 42 | 42733 | 204525 | 53101766 |
Thrombin time abnormal | 64.78 | 14.69 | 11 | 42764 | 3 | 53306288 |
International normalised ratio | 64.32 | 14.69 | 15 | 42760 | 80 | 53306211 |
Nausea | 62.54 | 14.69 | 354 | 42421 | 755737 | 52550554 |
Contraindicated product administered | 62.18 | 14.69 | 16 | 42759 | 135613 | 53170678 |
Neutropenia | 62 | 14.69 | 25 | 42750 | 159160 | 53147131 |
Product dose omission issue | 61.32 | 14.69 | 39 | 42736 | 191581 | 53114710 |
Drug interaction | 60.99 | 14.69 | 341 | 42434 | 218988 | 53087303 |
Activated partial thromboplastin time abnormal | 60.35 | 14.69 | 15 | 42760 | 109 | 53306182 |
Craniocerebral injury | 59.92 | 14.69 | 32 | 42743 | 2366 | 53303925 |
Anticoagulation drug level increased | 59.87 | 14.69 | 17 | 42758 | 216 | 53306075 |
Thrombosis | 59.76 | 14.69 | 143 | 42632 | 60650 | 53245641 |
Hip fracture | 59.64 | 14.69 | 92 | 42683 | 28165 | 53278126 |
Treatment failure | 59.15 | 14.69 | 15 | 42760 | 128388 | 53177903 |
Glossodynia | 58.91 | 14.69 | 6 | 42769 | 100285 | 53206006 |
Cardiac valve replacement complication | 58.38 | 14.69 | 16 | 42759 | 177 | 53306114 |
Peripheral swelling | 58.08 | 14.69 | 48 | 42727 | 206060 | 53100231 |
Intestinal ischaemia | 57.73 | 14.69 | 48 | 42727 | 7454 | 53298837 |
Peripheral ischaemia | 57.37 | 14.69 | 40 | 42735 | 4779 | 53301512 |
Intra-abdominal haemorrhage | 56.71 | 14.69 | 31 | 42744 | 2401 | 53303890 |
Cerebral ischaemia | 56.24 | 14.69 | 45 | 42730 | 6620 | 53299671 |
Intracardiac thrombus | 56.04 | 14.69 | 31 | 42744 | 2458 | 53303833 |
Puncture site haemorrhage | 55.91 | 14.69 | 17 | 42758 | 278 | 53306013 |
Product use issue | 55.88 | 14.69 | 21 | 42754 | 139563 | 53166728 |
Strangulated hernia | 54.89 | 14.69 | 12 | 42763 | 45 | 53306246 |
Cerebral artery embolism | 54.75 | 14.69 | 22 | 42753 | 843 | 53305448 |
Colon cancer | 54.04 | 14.69 | 52 | 42723 | 9773 | 53296518 |
Iron deficiency anaemia | 53.25 | 14.69 | 70 | 42705 | 18510 | 53287781 |
Toxicity to various agents | 52.73 | 14.69 | 59 | 42716 | 219539 | 53086752 |
Acute abdomen | 52.65 | 14.69 | 26 | 42749 | 1632 | 53304659 |
Traumatic intracranial haemorrhage | 52.58 | 14.69 | 17 | 42758 | 343 | 53305948 |
Retroperitoneal haemorrhage | 51.69 | 14.69 | 31 | 42744 | 2863 | 53303428 |
Blood urine present | 50.97 | 14.69 | 58 | 42717 | 13227 | 53293064 |
Gastritis erosive | 49.77 | 14.69 | 39 | 42736 | 5567 | 53300724 |
Swelling | 49.64 | 14.69 | 48 | 42727 | 191057 | 53115234 |
Alopecia | 49.06 | 14.69 | 70 | 42705 | 234513 | 53071778 |
Cardiac perforation | 46.96 | 14.69 | 11 | 42764 | 60 | 53306231 |
Embolic cerebral infarction | 46.39 | 14.69 | 17 | 42758 | 505 | 53305786 |
Infection | 46.20 | 14.69 | 42 | 42733 | 172163 | 53134128 |
Back pain | 45.99 | 14.69 | 73 | 42702 | 234174 | 53072117 |
Haemarthrosis | 45.75 | 14.69 | 30 | 42745 | 3240 | 53303051 |
Shock | 45.59 | 14.69 | 73 | 42702 | 23066 | 53283225 |
Chills | 45.03 | 14.69 | 14 | 42761 | 104834 | 53201457 |
Death | 44.23 | 14.69 | 459 | 42316 | 356773 | 52949518 |
Neuropathy peripheral | 43.92 | 14.69 | 14 | 42761 | 103173 | 53203118 |
Haemoperitoneum | 43.89 | 14.69 | 27 | 42748 | 2610 | 53303681 |
Acute myocardial infarction | 43.82 | 14.69 | 88 | 42687 | 33147 | 53273144 |
Multiple organ dysfunction syndrome | 43.37 | 14.69 | 120 | 42655 | 55557 | 53250734 |
Lower respiratory tract infection | 43.12 | 14.69 | 10 | 42765 | 90971 | 53215320 |
Peripheral artery thrombosis | 43.12 | 14.69 | 24 | 42751 | 1926 | 53304365 |
Contusion | 42.70 | 14.69 | 189 | 42586 | 110543 | 53195748 |
Microcytic anaemia | 42.42 | 14.69 | 29 | 42746 | 3356 | 53302935 |
Haemorrhage subcutaneous | 42.38 | 14.69 | 28 | 42747 | 3063 | 53303228 |
Stomatitis | 42.34 | 14.69 | 13 | 42762 | 98145 | 53208146 |
Femoral neck fracture | 41.70 | 14.69 | 42 | 42733 | 8341 | 53297950 |
Disease progression | 41.34 | 14.69 | 15 | 42760 | 101905 | 53204386 |
Vaginal haemorrhage | 40.19 | 14.69 | 75 | 42700 | 26766 | 53279525 |
Intraventricular haemorrhage | 39.67 | 14.69 | 23 | 42752 | 1995 | 53304296 |
Colitis ischaemic | 39.24 | 14.69 | 46 | 42729 | 10828 | 53295463 |
Pruritus | 39.01 | 14.69 | 114 | 42661 | 293718 | 53012573 |
Discomfort | 38.81 | 14.69 | 14 | 42761 | 95458 | 53210833 |
Haemorrhagic cerebral infarction | 38.61 | 14.69 | 16 | 42759 | 664 | 53305627 |
Diverticulum | 37.88 | 14.69 | 47 | 42728 | 11732 | 53294559 |
Wound haemorrhage | 37.76 | 14.69 | 23 | 42752 | 2184 | 53304107 |
Hypocoagulable state | 37.66 | 14.69 | 18 | 42757 | 1051 | 53305240 |
Cerebral mass effect | 37.22 | 14.69 | 17 | 42758 | 895 | 53305396 |
Product use in unapproved indication | 37.09 | 14.69 | 22 | 42753 | 112267 | 53194024 |
Asthma | 36.49 | 14.69 | 21 | 42754 | 108951 | 53197340 |
Skull fracture | 35.97 | 14.69 | 17 | 42758 | 968 | 53305323 |
Skin haemorrhage | 35.68 | 14.69 | 35 | 42740 | 6732 | 53299559 |
Subcutaneous haematoma | 35.55 | 14.69 | 20 | 42755 | 1638 | 53304653 |
Exsanguination | 34.90 | 14.69 | 7 | 42768 | 15 | 53306276 |
Diverticulum intestinal haemorrhagic | 34.38 | 14.69 | 18 | 42757 | 1278 | 53305013 |
Prothrombin time abnormal | 34.33 | 14.69 | 13 | 42762 | 424 | 53305867 |
Ischaemic cerebral infarction | 34.20 | 14.69 | 18 | 42757 | 1292 | 53304999 |
Influenza | 33.95 | 14.69 | 17 | 42758 | 95362 | 53210929 |
Prothrombin time shortened | 33.78 | 14.69 | 20 | 42755 | 1804 | 53304487 |
Coagulation test abnormal | 33.70 | 14.69 | 15 | 42760 | 743 | 53305548 |
Drug abuse | 33.55 | 14.69 | 6 | 42769 | 65520 | 53240771 |
Wound | 33.07 | 14.69 | 16 | 42759 | 91541 | 53214750 |
White blood cell count decreased | 32.61 | 14.69 | 31 | 42744 | 124444 | 53181847 |
Cardiac failure congestive | 32.54 | 14.69 | 154 | 42621 | 92603 | 53213688 |
Intentional product use issue | 32.37 | 14.69 | 9 | 42766 | 72485 | 53233806 |
Mesenteric artery embolism | 32.14 | 14.69 | 6 | 42769 | 7 | 53306284 |
Stress | 32.04 | 14.69 | 4 | 42771 | 57080 | 53249211 |
Upper respiratory tract infection | 31.95 | 14.69 | 8 | 42767 | 69089 | 53237202 |
Anticoagulation drug level above therapeutic | 31.63 | 14.69 | 17 | 42758 | 1273 | 53305018 |
Small intestinal haemorrhage | 31.09 | 14.69 | 20 | 42755 | 2091 | 53304200 |
Pelvic haematoma | 31.07 | 14.69 | 13 | 42762 | 553 | 53305738 |
Coagulation factor increased | 30.90 | 14.69 | 6 | 42769 | 10 | 53306281 |
Incarcerated hernia | 30.57 | 14.69 | 9 | 42766 | 131 | 53306160 |
Ecchymosis | 30.54 | 14.69 | 41 | 42734 | 11058 | 53295233 |
Psoriasis | 30.29 | 14.69 | 16 | 42759 | 87073 | 53219218 |
Post procedural haematoma | 30.24 | 14.69 | 17 | 42758 | 1391 | 53304900 |
Prothrombin time ratio decreased | 30.11 | 14.69 | 12 | 42763 | 450 | 53305841 |
Ischaemia | 29.90 | 14.69 | 27 | 42748 | 4681 | 53301610 |
Constipation | 29.31 | 14.69 | 73 | 42702 | 198339 | 53107952 |
Diarrhoea | 29.29 | 14.69 | 341 | 42434 | 625205 | 52681086 |
Cough | 29.01 | 14.69 | 107 | 42668 | 256786 | 53049505 |
Intracranial haematoma | 28.78 | 14.69 | 11 | 42764 | 368 | 53305923 |
Gastric ulcer haemorrhage | 28.14 | 14.69 | 27 | 42748 | 5055 | 53301236 |
Hypochromic anaemia | 28.07 | 14.69 | 18 | 42757 | 1871 | 53304420 |
Oesophageal ulcer | 28.05 | 14.69 | 25 | 42750 | 4261 | 53302030 |
Femoral artery embolism | 27.91 | 14.69 | 7 | 42768 | 53 | 53306238 |
Haematocrit decreased | 27.63 | 14.69 | 79 | 42696 | 37252 | 53269039 |
Therapeutic response decreased | 27.53 | 14.69 | 3 | 42772 | 47566 | 53258725 |
Insomnia | 27.49 | 14.69 | 69 | 42706 | 187003 | 53119288 |
Brain contusion | 27.26 | 14.69 | 12 | 42763 | 579 | 53305712 |
Phlebitis | 27.17 | 14.69 | 29 | 42746 | 6158 | 53300133 |
Road traffic accident | 27.03 | 14.69 | 62 | 42713 | 25569 | 53280722 |
Heart transplant | 27 | 14.69 | 11 | 42764 | 437 | 53305854 |
Brain herniation | 26.92 | 14.69 | 22 | 42753 | 3334 | 53302957 |
Gastritis haemorrhagic | 26.77 | 14.69 | 16 | 42759 | 1468 | 53304823 |
Therapeutic product effect incomplete | 26.29 | 14.69 | 21 | 42754 | 91763 | 53214528 |
Neutrophil count decreased | 26.24 | 14.69 | 4 | 42771 | 49094 | 53257197 |
Atrial flutter | 25.74 | 14.69 | 35 | 42740 | 9556 | 53296735 |
Paraesthesia | 25.70 | 14.69 | 39 | 42736 | 127476 | 53178815 |
Occult blood positive | 25.35 | 14.69 | 22 | 42753 | 3620 | 53302671 |
Pulmonary alveolar haemorrhage | 25.32 | 14.69 | 24 | 42751 | 4426 | 53301865 |
Rhinorrhoea | 25.16 | 14.69 | 6 | 42769 | 53572 | 53252719 |
Mobility decreased | 25.10 | 14.69 | 15 | 42760 | 76256 | 53230035 |
Oesophageal pain | 24.62 | 14.69 | 20 | 42755 | 3006 | 53303285 |
Dysphagia | 24.59 | 14.69 | 133 | 42642 | 84264 | 53222027 |
Disseminated intravascular coagulation | 24.55 | 14.69 | 51 | 42724 | 19668 | 53286623 |
Suicidal ideation | 24.37 | 14.69 | 9 | 42766 | 60502 | 53245789 |
Pelvic fracture | 24.34 | 14.69 | 39 | 42736 | 12325 | 53293966 |
Petechiae | 24.21 | 14.69 | 41 | 42734 | 13564 | 53292727 |
Hepatic enzyme increased | 24.10 | 14.69 | 40 | 42735 | 126155 | 53180136 |
Pericarditis | 23.65 | 14.69 | 11 | 42764 | 64395 | 53241896 |
Hypotension | 23.58 | 14.69 | 309 | 42466 | 253767 | 53052524 |
Impaired healing | 23.52 | 14.69 | 11 | 42764 | 64194 | 53242097 |
Basal ganglia haemorrhage | 23.41 | 14.69 | 11 | 42764 | 618 | 53305673 |
Conjunctival haemorrhage | 23.40 | 14.69 | 20 | 42755 | 3224 | 53303067 |
Intestinal infarction | 23.15 | 14.69 | 13 | 42762 | 1061 | 53305230 |
Gastrointestinal necrosis | 22.79 | 14.69 | 19 | 42756 | 2961 | 53303330 |
Haemoglobin abnormal | 22.73 | 14.69 | 23 | 42752 | 4591 | 53301700 |
Irritable bowel syndrome | 22.32 | 14.69 | 4 | 42771 | 43628 | 53262663 |
Prothrombin time | 22.23 | 14.69 | 5 | 42770 | 22 | 53306269 |
Gastric ulcer | 21.91 | 14.69 | 54 | 42721 | 23315 | 53282976 |
Arterial haemorrhage | 21.75 | 14.69 | 15 | 42760 | 1761 | 53304530 |
Weight decreased | 21.51 | 14.69 | 106 | 42669 | 234842 | 53071449 |
Haemorrhagic diathesis | 21.48 | 14.69 | 22 | 42753 | 4456 | 53301835 |
Influenza like illness | 21.43 | 14.69 | 11 | 42764 | 60848 | 53245443 |
Haemorrhagic arteriovenous malformation | 21.39 | 14.69 | 7 | 42768 | 147 | 53306144 |
Hypoaesthesia | 21.17 | 14.69 | 47 | 42728 | 132948 | 53173343 |
Haemorrhoids | 20.99 | 14.69 | 49 | 42726 | 20440 | 53285851 |
Abdominal wall haematoma | 20.65 | 14.69 | 18 | 42757 | 2980 | 53303311 |
Haemorrhage urinary tract | 20.60 | 14.69 | 11 | 42764 | 813 | 53305478 |
Pain in extremity | 20.52 | 14.69 | 139 | 42636 | 284911 | 53021380 |
Sepsis | 20.40 | 14.69 | 193 | 42582 | 146236 | 53160055 |
Cardiogenic shock | 20.36 | 14.69 | 44 | 42731 | 17438 | 53288853 |
Osteoarthritis | 20.34 | 14.69 | 16 | 42759 | 70470 | 53235821 |
Prothrombin level decreased | 20.33 | 14.69 | 10 | 42765 | 622 | 53305669 |
Injection site bruising | 20.27 | 14.69 | 3 | 42772 | 37643 | 53268648 |
Vomiting | 20.24 | 14.69 | 279 | 42496 | 496860 | 52809431 |
Post procedural haematuria | 20.04 | 14.69 | 5 | 42770 | 37 | 53306254 |
Syncope | 20.01 | 14.69 | 156 | 42619 | 111837 | 53194454 |
Lacunar infarction | 19.81 | 14.69 | 19 | 42756 | 3555 | 53302736 |
Myocardial infarction | 19.79 | 14.69 | 142 | 42633 | 99212 | 53207079 |
Gastritis | 19.76 | 14.69 | 69 | 42706 | 36165 | 53270126 |
Intentional overdose | 19.72 | 14.69 | 15 | 42760 | 67190 | 53239101 |
Cardiac failure chronic | 19.69 | 14.69 | 20 | 42755 | 4010 | 53302281 |
Activated partial thromboplastin time | 19.52 | 14.69 | 4 | 42771 | 10 | 53306281 |
Neurologic neglect syndrome | 19.48 | 14.69 | 12 | 42763 | 1163 | 53305128 |
Splenic haematoma | 19.46 | 14.69 | 6 | 42769 | 103 | 53306188 |
Renal infarct | 19.36 | 14.69 | 13 | 42762 | 1461 | 53304830 |
Acute coronary syndrome | 19.33 | 14.69 | 32 | 42743 | 10392 | 53295899 |
Urticaria | 19.28 | 14.69 | 51 | 42724 | 135834 | 53170457 |
Multiple sclerosis relapse | 19.23 | 14.69 | 6 | 42769 | 44847 | 53261444 |
Rib fracture | 19.16 | 14.69 | 47 | 42728 | 20231 | 53286060 |
Cardioversion | 19.13 | 14.69 | 12 | 42763 | 1201 | 53305090 |
Occult blood | 19.12 | 14.69 | 12 | 42763 | 1202 | 53305089 |
Helicobacter infection | 19.10 | 14.69 | 4 | 42771 | 39065 | 53267226 |
Infarction | 18.98 | 14.69 | 16 | 42759 | 2531 | 53303760 |
Ill-defined disorder | 18.85 | 14.69 | 8 | 42767 | 49436 | 53256855 |
Thrombotic cerebral infarction | 18.75 | 14.69 | 6 | 42769 | 117 | 53306174 |
Overdose | 18.66 | 14.69 | 149 | 42626 | 107587 | 53198704 |
Thrombotic stroke | 18.65 | 14.69 | 9 | 42766 | 537 | 53305754 |
Malignant neoplasm progression | 18.52 | 14.69 | 18 | 42757 | 71523 | 53234768 |
Diverticulitis intestinal haemorrhagic | 18.33 | 14.69 | 6 | 42769 | 126 | 53306165 |
Arteriovenous malformation | 18.27 | 14.69 | 12 | 42763 | 1299 | 53304992 |
Nasal congestion | 18.22 | 14.69 | 10 | 42765 | 53277 | 53253014 |
Cardiac ablation | 18.17 | 14.69 | 12 | 42763 | 1312 | 53304979 |
Haemodynamic instability | 18.15 | 14.69 | 28 | 42747 | 8566 | 53297725 |
Haemorrhagic disorder | 17.86 | 14.69 | 10 | 42765 | 812 | 53305479 |
Spontaneous haematoma | 17.80 | 14.69 | 10 | 42765 | 817 | 53305474 |
Migraine | 17.79 | 14.69 | 23 | 42752 | 80394 | 53225897 |
Aortic thrombosis | 17.70 | 14.69 | 11 | 42764 | 1083 | 53305208 |
Herpes zoster | 17.61 | 14.69 | 20 | 42755 | 73999 | 53232292 |
Abdominal wall haemorrhage | 17.54 | 14.69 | 6 | 42769 | 145 | 53306146 |
Sleep disorder | 17.45 | 14.69 | 13 | 42762 | 58857 | 53247434 |
Arthritis | 17.30 | 14.69 | 27 | 42748 | 87271 | 53219020 |
Gastric cancer | 17.29 | 14.69 | 17 | 42758 | 3280 | 53303011 |
Brain stem stroke | 17.28 | 14.69 | 7 | 42768 | 274 | 53306017 |
Internal haemorrhage | 17.17 | 14.69 | 20 | 42755 | 4676 | 53301615 |
Musculoskeletal pain | 17.16 | 14.69 | 21 | 42754 | 75179 | 53231112 |
Oesophagitis | 17.16 | 14.69 | 37 | 42738 | 14640 | 53291651 |
Rectal perforation | 17.15 | 14.69 | 8 | 42767 | 442 | 53305849 |
Cerebellar haemorrhage | 17.14 | 14.69 | 12 | 42763 | 1443 | 53304848 |
Therapy non-responder | 17.11 | 14.69 | 9 | 42766 | 49111 | 53257180 |
Blood creatinine increased | 16.96 | 14.69 | 119 | 42656 | 82543 | 53223748 |
Somnolence | 16.93 | 14.69 | 73 | 42702 | 167661 | 53138630 |
Embolism arterial | 16.84 | 14.69 | 11 | 42764 | 1180 | 53305111 |
Muscle spasms | 16.64 | 14.69 | 54 | 42721 | 134741 | 53171550 |
Loss of personal independence in daily activities | 16.46 | 14.69 | 19 | 42756 | 69796 | 53236495 |
Spinal cord haematoma | 16.41 | 14.69 | 6 | 42769 | 177 | 53306114 |
Leukopenia | 16.26 | 14.69 | 21 | 42754 | 73442 | 53232849 |
Blood glucose increased | 16.23 | 14.69 | 23 | 42752 | 77338 | 53228953 |
Rectal ulcer | 16.20 | 14.69 | 11 | 42764 | 1259 | 53305032 |
Dysarthria | 16.19 | 14.69 | 70 | 42705 | 40498 | 53265793 |
Mucosal inflammation | 16.19 | 14.69 | 7 | 42768 | 42777 | 53263514 |
Blood pressure increased | 16.18 | 14.69 | 58 | 42717 | 140421 | 53165870 |
Peritonitis | 16.15 | 14.69 | 46 | 42729 | 21641 | 53284650 |
Off label use | 16.14 | 14.69 | 274 | 42501 | 471938 | 52834353 |
Hospitalisation | 16.03 | 14.69 | 20 | 42755 | 70992 | 53235299 |
Type 2 diabetes mellitus | 15.99 | 14.69 | 3 | 42772 | 31667 | 53274624 |
Carotid artery occlusion | 15.97 | 14.69 | 15 | 42760 | 2734 | 53303557 |
Inappropriate schedule of product administration | 15.97 | 14.69 | 22 | 42753 | 74856 | 53231435 |
Hot flush | 15.90 | 14.69 | 9 | 42766 | 47151 | 53259140 |
Bronchitis | 15.87 | 14.69 | 42 | 42733 | 111857 | 53194434 |
Depressed mood | 15.75 | 14.69 | 5 | 42770 | 36959 | 53269332 |
COVID-19 | 15.70 | 14.69 | 5 | 42770 | 36883 | 53269408 |
Brain stem haemorrhage | 15.64 | 14.69 | 9 | 42766 | 770 | 53305521 |
Pancytopenia | 15.42 | 14.69 | 31 | 42744 | 90897 | 53215394 |
Duodenal ulcer haemorrhage | 15.41 | 14.69 | 14 | 42761 | 2446 | 53303845 |
Extradural haematoma | 15.29 | 14.69 | 12 | 42763 | 1716 | 53304575 |
Lymphadenopathy | 15.28 | 14.69 | 5 | 42770 | 36250 | 53270041 |
Hypertensive crisis | 15.20 | 14.69 | 35 | 42740 | 14471 | 53291820 |
Venous thrombosis limb | 15.10 | 14.69 | 15 | 42760 | 2928 | 53303363 |
Erosive oesophagitis | 15.10 | 14.69 | 12 | 42763 | 1747 | 53304544 |
Phlebitis deep | 15.10 | 14.69 | 3 | 42772 | 6 | 53306285 |
Polyp | 15.00 | 14.69 | 21 | 42754 | 5893 | 53300398 |
Globulins decreased | 14.86 | 14.69 | 6 | 42769 | 233 | 53306058 |
Myalgia | 14.79 | 14.69 | 56 | 42719 | 133435 | 53172856 |
Facial paresis | 14.74 | 14.69 | 16 | 42759 | 3464 | 53302827 |
Anaphylactic reaction | 14.72 | 14.69 | 15 | 42760 | 58311 | 53247980 |
Tongue haemorrhage | 14.71 | 14.69 | 7 | 42768 | 405 | 53305886 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Gastrointestinal haemorrhage | 2749.41 | 14.55 | 1672 | 47103 | 85210 | 32379541 |
Ischaemic stroke | 2276.08 | 14.55 | 890 | 47885 | 16686 | 32448065 |
Cerebrovascular accident | 1644.67 | 14.55 | 1214 | 47561 | 85106 | 32379645 |
Haemorrhage | 1092.11 | 14.55 | 762 | 48013 | 48686 | 32416065 |
Haemorrhage intracranial | 865.60 | 14.55 | 439 | 48336 | 15448 | 32449303 |
Cerebral infarction | 821.62 | 14.55 | 513 | 48262 | 27101 | 32437650 |
Rectal haemorrhage | 819.33 | 14.55 | 574 | 48201 | 36849 | 32427902 |
Cerebral haemorrhage | 742.04 | 14.55 | 525 | 48250 | 34222 | 32430529 |
Melaena | 726.96 | 14.55 | 518 | 48257 | 34147 | 32430604 |
Atrial thrombosis | 632.00 | 14.55 | 197 | 48578 | 1790 | 32462961 |
Embolic stroke | 628.19 | 14.55 | 230 | 48545 | 3544 | 32461207 |
Subdural haematoma | 594.03 | 14.55 | 371 | 48404 | 19582 | 32445169 |
Cardiac tamponade | 565.42 | 14.55 | 231 | 48544 | 4844 | 32459907 |
Haematuria | 428.86 | 14.55 | 441 | 48334 | 47920 | 32416831 |
Fall | 392.81 | 14.55 | 890 | 47885 | 195311 | 32269440 |
Transient ischaemic attack | 378.70 | 14.55 | 312 | 48463 | 25482 | 32439269 |
Lower gastrointestinal haemorrhage | 367.72 | 14.55 | 204 | 48571 | 8613 | 32456138 |
Activated partial thromboplastin time prolonged | 367.41 | 14.55 | 201 | 48574 | 8254 | 32456497 |
Shock haemorrhagic | 321.85 | 14.55 | 200 | 48575 | 10445 | 32454306 |
Hemiparesis | 307.96 | 14.55 | 225 | 48550 | 15382 | 32449369 |
Upper gastrointestinal haemorrhage | 264.53 | 14.55 | 246 | 48529 | 23603 | 32441148 |
Blood loss anaemia | 239.17 | 14.55 | 149 | 48626 | 7813 | 32456938 |
Deep vein thrombosis | 229.89 | 14.55 | 372 | 48403 | 63341 | 32401410 |
Procoagulant therapy | 222.22 | 14.55 | 42 | 48733 | 10 | 32464741 |
Coagulopathy | 221.08 | 14.55 | 204 | 48571 | 19373 | 32445378 |
Subarachnoid haemorrhage | 211.96 | 14.55 | 153 | 48622 | 10258 | 32454493 |
Pulmonary embolism | 210.10 | 14.55 | 417 | 48358 | 83242 | 32381509 |
Pericardial haemorrhage | 208.93 | 14.55 | 99 | 48676 | 2987 | 32461764 |
Thrombin time prolonged | 206.97 | 14.55 | 49 | 48726 | 128 | 32464623 |
Haemorrhagic stroke | 206.71 | 14.55 | 126 | 48649 | 6352 | 32458399 |
Haematoma | 202.15 | 14.55 | 220 | 48555 | 25464 | 32439287 |
Aphasia | 179.08 | 14.55 | 187 | 48588 | 20641 | 32444110 |
Haemothorax | 177.77 | 14.55 | 95 | 48680 | 3717 | 32461034 |
Aortic dissection | 165.93 | 14.55 | 80 | 48695 | 2510 | 32462241 |
Hemiplegia | 153.37 | 14.55 | 108 | 48667 | 6960 | 32457791 |
Haematemesis | 150.18 | 14.55 | 196 | 48579 | 27439 | 32437312 |
Epistaxis | 143.21 | 14.55 | 281 | 48494 | 55574 | 32409177 |
Head injury | 141.93 | 14.55 | 153 | 48622 | 17510 | 32447241 |
Haemorrhagic transformation stroke | 138.30 | 14.55 | 58 | 48717 | 1300 | 32463451 |
Procedural haemorrhage | 133.01 | 14.55 | 68 | 48707 | 2425 | 32462326 |
Febrile neutropenia | 132.53 | 14.55 | 13 | 48762 | 119553 | 32345198 |
Toxicity to various agents | 130.47 | 14.55 | 52 | 48723 | 177989 | 32286762 |
Pyrexia | 130.40 | 14.55 | 174 | 48601 | 319794 | 32144957 |
Neutropenia | 124.79 | 14.55 | 30 | 48745 | 142145 | 32322606 |
Haematochezia | 121.45 | 14.55 | 214 | 48561 | 38994 | 32425757 |
Completed suicide | 120.79 | 14.55 | 4 | 48771 | 92513 | 32372238 |
Intracardiac thrombus | 115.23 | 14.55 | 62 | 48713 | 2459 | 32462292 |
Subdural haemorrhage | 115.11 | 14.55 | 66 | 48709 | 2967 | 32461784 |
Haemoptysis | 114.37 | 14.55 | 191 | 48584 | 33334 | 32431417 |
Cerebral haematoma | 112.55 | 14.55 | 77 | 48698 | 4734 | 32460017 |
Anaemia | 112.45 | 14.55 | 644 | 48131 | 222980 | 32241771 |
Intestinal haemorrhage | 105.94 | 14.55 | 65 | 48710 | 3314 | 32461437 |
Peripheral embolism | 103.19 | 14.55 | 43 | 48732 | 948 | 32463803 |
Brain contusion | 102.35 | 14.55 | 41 | 48734 | 814 | 32463937 |
International normalised ratio increased | 99.23 | 14.55 | 224 | 48551 | 48811 | 32415940 |
Post procedural haemorrhage | 94.64 | 14.55 | 87 | 48688 | 8213 | 32456538 |
Pericardial effusion | 93.51 | 14.55 | 142 | 48633 | 22860 | 32441891 |
Product dose omission issue | 93.25 | 14.55 | 20 | 48755 | 102555 | 32362196 |
Fatigue | 89.39 | 14.55 | 252 | 48523 | 350449 | 32114302 |
Cardiac failure | 87.27 | 14.55 | 319 | 48456 | 91354 | 32373397 |
Colon cancer | 86.02 | 14.55 | 85 | 48690 | 8781 | 32455970 |
Oesophageal pain | 84.10 | 14.55 | 35 | 48740 | 769 | 32463982 |
Gastric haemorrhage | 80.11 | 14.55 | 86 | 48689 | 9790 | 32454961 |
Drug abuse | 78.56 | 14.55 | 13 | 48762 | 80230 | 32384521 |
Large intestinal haemorrhage | 77.56 | 14.55 | 41 | 48734 | 1568 | 32463183 |
Anticoagulation drug level increased | 76.16 | 14.55 | 29 | 48746 | 500 | 32464251 |
Disease progression | 74.85 | 14.55 | 19 | 48756 | 86843 | 32377908 |
Faeces discoloured | 72.36 | 14.55 | 100 | 48675 | 14777 | 32449974 |
Pain | 72.20 | 14.55 | 106 | 48669 | 187450 | 32277301 |
Depression | 71.58 | 14.55 | 28 | 48747 | 97032 | 32367719 |
Renal impairment | 71.26 | 14.55 | 300 | 48475 | 91672 | 32373079 |
Pancytopenia | 71.21 | 14.55 | 24 | 48751 | 91211 | 32373540 |
Hypovolaemic shock | 70.63 | 14.55 | 68 | 48707 | 6804 | 32457947 |
Road traffic accident | 70.21 | 14.55 | 107 | 48668 | 17274 | 32447477 |
Pulmonary haemorrhage | 68.21 | 14.55 | 79 | 48696 | 9778 | 32454973 |
Rash | 67.97 | 14.55 | 132 | 48643 | 209201 | 32255550 |
Extradural haematoma | 66.72 | 14.55 | 34 | 48741 | 1204 | 32463547 |
Traumatic intracranial haemorrhage | 65.69 | 14.55 | 28 | 48747 | 654 | 32464097 |
Nausea | 65.50 | 14.55 | 254 | 48521 | 320595 | 32144156 |
Drug hypersensitivity | 65.30 | 14.55 | 15 | 48760 | 73385 | 32391366 |
Product use in unapproved indication | 64.56 | 14.55 | 25 | 48750 | 87179 | 32377572 |
Blood urine present | 64.27 | 14.55 | 79 | 48696 | 10406 | 32454345 |
Cerebral artery occlusion | 64.26 | 14.55 | 29 | 48746 | 780 | 32463971 |
Diarrhoea | 63.97 | 14.55 | 306 | 48469 | 364496 | 32100255 |
Intraventricular haemorrhage | 63.16 | 14.55 | 46 | 48729 | 3124 | 32461627 |
Leukopenia | 62.88 | 14.55 | 8 | 48767 | 60114 | 32404637 |
Haemorrhagic infarction | 62.80 | 14.55 | 24 | 48751 | 418 | 32464333 |
Embolism | 62.68 | 14.55 | 66 | 48709 | 7348 | 32457403 |
Coagulation test abnormal | 62.51 | 14.55 | 25 | 48750 | 494 | 32464257 |
Dyspepsia | 62.43 | 14.55 | 147 | 48628 | 32908 | 32431843 |
Contusion | 61.22 | 14.55 | 147 | 48628 | 33321 | 32431430 |
Urinary bladder haemorrhage | 60.29 | 14.55 | 36 | 48739 | 1746 | 32463005 |
White blood cell count decreased | 59.90 | 14.55 | 31 | 48744 | 91167 | 32373584 |
Gingival bleeding | 58.76 | 14.55 | 62 | 48713 | 6919 | 32457832 |
Tremor | 57.41 | 14.55 | 25 | 48750 | 81252 | 32383499 |
Wound secretion | 56.38 | 14.55 | 40 | 48735 | 2607 | 32462144 |
Embolic cerebral infarction | 55.58 | 14.55 | 25 | 48750 | 667 | 32464084 |
Splenic rupture | 55.50 | 14.55 | 33 | 48742 | 1588 | 32463163 |
Cerebral mass effect | 55.47 | 14.55 | 27 | 48748 | 865 | 32463886 |
Coagulation time prolonged | 54.81 | 14.55 | 31 | 48744 | 1357 | 32463394 |
Traumatic haemorrhage | 54.40 | 14.55 | 25 | 48750 | 702 | 32464049 |
Skull fracture | 54.02 | 14.55 | 27 | 48748 | 917 | 32463834 |
Anorectal discomfort | 53.47 | 14.55 | 34 | 48741 | 1846 | 32462905 |
Insomnia | 50.11 | 14.55 | 46 | 48729 | 100302 | 32364449 |
Thrombosis | 49.34 | 14.55 | 166 | 48609 | 45588 | 32419163 |
Chills | 49.15 | 14.55 | 28 | 48747 | 78056 | 32386695 |
Rheumatoid arthritis | 48.90 | 14.55 | 5 | 48770 | 44539 | 32420212 |
Surgery | 48.69 | 14.55 | 76 | 48699 | 12523 | 32452228 |
Cerebral artery embolism | 47.97 | 14.55 | 25 | 48750 | 928 | 32463823 |
Anxiety | 47.95 | 14.55 | 44 | 48731 | 95961 | 32368790 |
Infusion related reaction | 47.84 | 14.55 | 6 | 48769 | 45593 | 32419158 |
Cardiac ablation | 47.41 | 14.55 | 22 | 48753 | 632 | 32464119 |
Vomiting | 47.01 | 14.55 | 188 | 48587 | 235369 | 32229382 |
Aortic aneurysm rupture | 46.93 | 14.55 | 26 | 48749 | 1093 | 32463658 |
Activated partial thromboplastin time abnormal | 46.66 | 14.55 | 13 | 48762 | 76 | 32464675 |
Neuropathy peripheral | 46.49 | 14.55 | 29 | 48746 | 76953 | 32387798 |
Embolism arterial | 46.46 | 14.55 | 21 | 48754 | 567 | 32464184 |
Condition aggravated | 46.38 | 14.55 | 103 | 48672 | 155558 | 32309193 |
Creatinine renal clearance decreased | 46.15 | 14.55 | 40 | 48735 | 3494 | 32461257 |
Intra-abdominal haemorrhage | 43.20 | 14.55 | 32 | 48743 | 2231 | 32462520 |
Traumatic haemothorax | 43.06 | 14.55 | 16 | 48759 | 257 | 32464494 |
Haemorrhoidal haemorrhage | 42.83 | 14.55 | 37 | 48738 | 3217 | 32461534 |
Strangulated hernia | 42.82 | 14.55 | 9 | 48766 | 10 | 32464741 |
Haemoglobin decreased | 42.39 | 14.55 | 316 | 48459 | 119355 | 32345396 |
Atrial fibrillation | 42.39 | 14.55 | 310 | 48465 | 116394 | 32348357 |
Weight increased | 42.18 | 14.55 | 38 | 48737 | 83625 | 32381126 |
Renal failure | 42.07 | 14.55 | 345 | 48430 | 134133 | 32330618 |
Arthralgia | 40.42 | 14.55 | 103 | 48672 | 148345 | 32316406 |
Psoriasis | 39.88 | 14.55 | 10 | 48765 | 46113 | 32418638 |
Agitation | 39.79 | 14.55 | 18 | 48757 | 57218 | 32407533 |
Off label use | 39.66 | 14.55 | 283 | 48492 | 306037 | 32158714 |
Neutrophil count decreased | 39.28 | 14.55 | 11 | 48764 | 47128 | 32417623 |
Muscle spasms | 39.21 | 14.55 | 29 | 48746 | 70389 | 32394362 |
Retroperitoneal haemorrhage | 38.95 | 14.55 | 33 | 48742 | 2795 | 32461956 |
Intentional product use issue | 38.80 | 14.55 | 8 | 48767 | 42203 | 32422548 |
Incarcerated hernia | 38.68 | 14.55 | 14 | 48761 | 208 | 32464543 |
Basal ganglia haemorrhage | 38.56 | 14.55 | 21 | 48754 | 853 | 32463898 |
Thrombin time abnormal | 38.53 | 14.55 | 7 | 48768 | 0 | 32464751 |
Acute abdomen | 37.70 | 14.55 | 28 | 48747 | 1960 | 32462791 |
Seizure | 37.69 | 14.55 | 61 | 48714 | 103793 | 32360958 |
Mouth haemorrhage | 37.67 | 14.55 | 43 | 48732 | 5238 | 32459513 |
Product use issue | 37.63 | 14.55 | 16 | 48759 | 52761 | 32411990 |
Cerebellar haemorrhage | 37.33 | 14.55 | 25 | 48750 | 1483 | 32463268 |
Renal infarct | 36.84 | 14.55 | 23 | 48752 | 1209 | 32463542 |
Malignant neoplasm progression | 36.84 | 14.55 | 38 | 48737 | 78458 | 32386293 |
Alanine aminotransferase increased | 36.83 | 14.55 | 38 | 48737 | 78441 | 32386310 |
Oesophageal ulcer | 36.76 | 14.55 | 35 | 48740 | 3453 | 32461298 |
International normalised ratio abnormal | 36.57 | 14.55 | 34 | 48741 | 3255 | 32461496 |
Dysarthria | 36.26 | 14.55 | 121 | 48654 | 33080 | 32431671 |
Mucosal inflammation | 36.06 | 14.55 | 4 | 48771 | 33430 | 32431321 |
Somnolence | 35.79 | 14.55 | 63 | 48712 | 103734 | 32361017 |
Acute kidney injury | 34.97 | 14.55 | 626 | 48149 | 292842 | 32171909 |
Ischaemia | 34.96 | 14.55 | 39 | 48736 | 4633 | 32460118 |
Haemorrhage urinary tract | 34.64 | 14.55 | 25 | 48750 | 1674 | 32463077 |
Heart transplant | 34.24 | 14.55 | 19 | 48756 | 801 | 32463950 |
Erythema | 33.88 | 14.55 | 45 | 48730 | 83060 | 32381691 |
International normalised ratio | 33.81 | 14.55 | 9 | 48766 | 43 | 32464708 |
Intracranial haematoma | 33.81 | 14.55 | 15 | 48760 | 387 | 32464364 |
Blood creatine phosphokinase increased | 33.70 | 14.55 | 13 | 48762 | 45463 | 32419288 |
Asthma | 33.66 | 14.55 | 12 | 48763 | 44053 | 32420698 |
Cardiac valve replacement complication | 33.64 | 14.55 | 9 | 48766 | 44 | 32464707 |
Pulmonary alveolar haemorrhage | 33.29 | 14.55 | 47 | 48728 | 7082 | 32457669 |
Multiple injuries | 33.23 | 14.55 | 26 | 48749 | 1967 | 32462784 |
Platelet count decreased | 33.16 | 14.55 | 77 | 48698 | 114514 | 32350237 |
Drug intolerance | 33.08 | 14.55 | 17 | 48758 | 50218 | 32414533 |
Coagulation time shortened | 33.07 | 14.55 | 13 | 48762 | 245 | 32464506 |
Activated partial thromboplastin time | 33.02 | 14.55 | 6 | 48769 | 0 | 32464751 |
Creatinine renal clearance | 33.02 | 14.55 | 6 | 48769 | 0 | 32464751 |
Cardioversion | 32.30 | 14.55 | 19 | 48756 | 896 | 32463855 |
C-reactive protein increased | 32.09 | 14.55 | 16 | 48759 | 48086 | 32416665 |
Femoral neck fracture | 31.99 | 14.55 | 31 | 48744 | 3125 | 32461626 |
Arterial thrombosis | 31.96 | 14.55 | 23 | 48752 | 1533 | 32463218 |
Gastrointestinal carcinoma | 31.81 | 14.55 | 21 | 48754 | 1216 | 32463535 |
Gastrointestinal motility disorder | 31.53 | 14.55 | 27 | 48748 | 2320 | 32462431 |
Hemianopia | 31.30 | 14.55 | 17 | 48758 | 687 | 32464064 |
Wound haemorrhage | 31.14 | 14.55 | 25 | 48750 | 1963 | 32462788 |
Cough | 30.77 | 14.55 | 106 | 48669 | 138711 | 32326040 |
Stomatitis | 30.65 | 14.55 | 11 | 48764 | 40218 | 32424533 |
Neurologic neglect syndrome | 29.87 | 14.55 | 11 | 48764 | 172 | 32464579 |
Aggression | 29.62 | 14.55 | 11 | 48764 | 39378 | 32425373 |
Appendicitis | 29.23 | 14.55 | 50 | 48725 | 8887 | 32455864 |
Craniocerebral injury | 29.19 | 14.55 | 29 | 48746 | 3014 | 32461737 |
Blood glucose increased | 29.04 | 14.55 | 33 | 48742 | 65208 | 32399543 |
Weight decreased | 28.90 | 14.55 | 138 | 48637 | 164680 | 32300071 |
Elderly | 28.87 | 14.55 | 6 | 48769 | 6 | 32464745 |
White blood cell count increased | 28.80 | 14.55 | 13 | 48762 | 41389 | 32423362 |
Iron deficiency anaemia | 28.79 | 14.55 | 52 | 48723 | 9649 | 32455102 |
Femur fracture | 28.65 | 14.55 | 46 | 48729 | 7762 | 32456989 |
Gastric cancer | 28.64 | 14.55 | 38 | 48737 | 5399 | 32459352 |
Large intestine polyp | 28.59 | 14.55 | 44 | 48731 | 7162 | 32457589 |
Oesophageal carcinoma | 28.43 | 14.55 | 33 | 48742 | 4093 | 32460658 |
Thrombotic stroke | 28.32 | 14.55 | 12 | 48763 | 276 | 32464475 |
Cardiac perforation | 28.18 | 14.55 | 9 | 48766 | 89 | 32464662 |
Plasma cell myeloma | 28.05 | 14.55 | 27 | 48748 | 57587 | 32407164 |
Joint swelling | 27.91 | 14.55 | 22 | 48753 | 51713 | 32413038 |
Acute myocardial infarction | 27.67 | 14.55 | 159 | 48616 | 54990 | 32409761 |
Haemorrhage subcutaneous | 27.11 | 14.55 | 25 | 48750 | 2368 | 32462383 |
Aspartate aminotransferase increased | 27.04 | 14.55 | 36 | 48739 | 66393 | 32398358 |
Injection site pain | 27.01 | 14.55 | 8 | 48767 | 33050 | 32431701 |
Infection | 26.92 | 14.55 | 54 | 48721 | 84661 | 32380090 |
Lumbar puncture | 26.76 | 14.55 | 9 | 48766 | 106 | 32464645 |
Nasopharyngitis | 26.55 | 14.55 | 34 | 48741 | 63753 | 32400998 |
Prothrombin time prolonged | 26.08 | 14.55 | 50 | 48725 | 9705 | 32455046 |
Mesenteric artery embolism | 25.92 | 14.55 | 8 | 48767 | 70 | 32464681 |
Infarction | 25.89 | 14.55 | 26 | 48749 | 2737 | 32462014 |
Ascites | 25.87 | 14.55 | 14 | 48761 | 40177 | 32424574 |
Peripheral artery thrombosis | 25.87 | 14.55 | 24 | 48751 | 2291 | 32462460 |
Intestinal ischaemia | 25.46 | 14.55 | 42 | 48733 | 7249 | 32457502 |
Cerebral ischaemia | 25.43 | 14.55 | 39 | 48736 | 6328 | 32458423 |
Rib fracture | 25.38 | 14.55 | 61 | 48714 | 13828 | 32450923 |
Anaphylactic reaction | 25.21 | 14.55 | 7 | 48768 | 30165 | 32434586 |
Hemianopia homonymous | 25.02 | 14.55 | 15 | 48760 | 733 | 32464018 |
Diverticulum intestinal haemorrhagic | 25.01 | 14.55 | 23 | 48752 | 2171 | 32462580 |
Ecchymosis | 24.74 | 14.55 | 40 | 48735 | 6788 | 32457963 |
Hyperhidrosis | 24.70 | 14.55 | 43 | 48732 | 71125 | 32393626 |
Cerebellar infarction | 24.40 | 14.55 | 22 | 48753 | 2025 | 32462726 |
Abnormal behaviour | 24.36 | 14.55 | 5 | 48770 | 26461 | 32438290 |
Rhabdomyolysis | 23.93 | 14.55 | 40 | 48735 | 67225 | 32397526 |
Exsanguination | 23.92 | 14.55 | 7 | 48768 | 50 | 32464701 |
Brain herniation | 23.45 | 14.55 | 29 | 48746 | 3842 | 32460909 |
Musculoskeletal stiffness | 23.40 | 14.55 | 15 | 48760 | 39249 | 32425502 |
Diabetes mellitus | 23.38 | 14.55 | 20 | 48755 | 45153 | 32419598 |
Pulmonary contusion | 23.34 | 14.55 | 7 | 48768 | 55 | 32464696 |
Feeling abnormal | 23.34 | 14.55 | 34 | 48741 | 60389 | 32404362 |
Gastric ulcer haemorrhage | 23.32 | 14.55 | 35 | 48740 | 5572 | 32459179 |
Arteriovenous malformation | 23.26 | 14.55 | 14 | 48761 | 689 | 32464062 |
Sinusitis | 23.15 | 14.55 | 13 | 48762 | 36547 | 32428204 |
Back pain | 23.14 | 14.55 | 87 | 48688 | 110966 | 32353785 |
Cholecystitis acute | 23.05 | 14.55 | 36 | 48739 | 5934 | 32458817 |
Stress | 22.93 | 14.55 | 4 | 48771 | 23778 | 32440973 |
Post procedural stroke | 22.84 | 14.55 | 6 | 48769 | 27 | 32464724 |
Herpes zoster | 22.74 | 14.55 | 10 | 48765 | 32331 | 32432420 |
Thrombocytopenia | 22.71 | 14.55 | 130 | 48645 | 148169 | 32316582 |
Dyskinesia | 22.70 | 14.55 | 4 | 48771 | 23599 | 32441152 |
Skin haemorrhage | 22.51 | 14.55 | 28 | 48747 | 3731 | 32461020 |
Electrocardiogram QT prolonged | 22.48 | 14.55 | 16 | 48759 | 39625 | 32425126 |
Catheter site haemorrhage | 22.41 | 14.55 | 22 | 48753 | 2253 | 32462498 |
Cerebral vascular occlusion | 22.02 | 14.55 | 4 | 48771 | 0 | 32464751 |
Irritability | 21.99 | 14.55 | 5 | 48770 | 24649 | 32440102 |
Colon neoplasm | 21.78 | 14.55 | 11 | 48764 | 382 | 32464369 |
Urticaria | 21.63 | 14.55 | 35 | 48740 | 59579 | 32405172 |
Hospitalisation | 21.54 | 14.55 | 25 | 48750 | 48946 | 32415805 |
Aneurysm ruptured | 21.54 | 14.55 | 12 | 48763 | 510 | 32464241 |
Drug ineffective | 21.53 | 14.55 | 426 | 48349 | 383051 | 32081700 |
Subarachnoid haematoma | 21.50 | 14.55 | 7 | 48768 | 74 | 32464677 |
Haemoglobin abnormal | 21.42 | 14.55 | 26 | 48749 | 3379 | 32461372 |
Vision blurred | 21.17 | 14.55 | 21 | 48754 | 44165 | 32420586 |
Subcutaneous haematoma | 21.07 | 14.55 | 15 | 48760 | 983 | 32463768 |
Haemorrhoids | 20.91 | 14.55 | 54 | 48721 | 12799 | 32451952 |
Thalamus haemorrhage | 20.87 | 14.55 | 15 | 48760 | 998 | 32463753 |
Injury | 20.77 | 14.55 | 77 | 48698 | 22168 | 32442583 |
Renal haemorrhage | 20.60 | 14.55 | 17 | 48758 | 1388 | 32463363 |
Peripheral swelling | 20.51 | 14.55 | 45 | 48730 | 68300 | 32396451 |
Pneumonia | 20.43 | 14.55 | 393 | 48382 | 354859 | 32109892 |
Productive cough | 20.38 | 14.55 | 13 | 48762 | 34103 | 32430648 |
Gastric ulcer | 20.36 | 14.55 | 61 | 48714 | 15748 | 32449003 |
Pneumonitis | 20.13 | 14.55 | 10 | 48765 | 30124 | 32434627 |
Ischaemic cerebral infarction | 20.07 | 14.55 | 15 | 48760 | 1060 | 32463691 |
Coronary artery embolism | 20.01 | 14.55 | 8 | 48767 | 158 | 32464593 |
Hallucination | 19.94 | 14.55 | 30 | 48745 | 52589 | 32412162 |
Drug reaction with eosinophilia and systemic symptoms | 19.93 | 14.55 | 12 | 48763 | 32473 | 32432278 |
Aortic aneurysm | 19.92 | 14.55 | 36 | 48739 | 6683 | 32458068 |
Therapeutic response decreased | 19.89 | 14.55 | 7 | 48768 | 25913 | 32438838 |
Influenza like illness | 19.71 | 14.55 | 8 | 48767 | 27132 | 32437619 |
Oxygen saturation decreased | 19.64 | 14.55 | 26 | 48749 | 48073 | 32416678 |
Cardiac pacemaker insertion | 19.52 | 14.55 | 22 | 48753 | 2643 | 32462108 |
Venous thrombosis | 19.46 | 14.55 | 25 | 48750 | 3442 | 32461309 |
Arterial injury | 19.44 | 14.55 | 10 | 48765 | 361 | 32464390 |
Myalgia | 19.39 | 14.55 | 60 | 48715 | 81170 | 32383581 |
Traumatic haematoma | 19.20 | 14.55 | 13 | 48762 | 785 | 32463966 |
Gastrointestinal angiodysplasia | 19.05 | 14.55 | 12 | 48763 | 641 | 32464110 |
Osteonecrosis of jaw | 18.98 | 14.55 | 3 | 48772 | 19163 | 32445588 |
Angioedema | 18.86 | 14.55 | 16 | 48759 | 36273 | 32428478 |
Urogenital haemorrhage | 18.77 | 14.55 | 11 | 48764 | 515 | 32464236 |
Dry skin | 18.74 | 14.55 | 7 | 48768 | 24971 | 32439780 |
Haemodynamic instability | 18.64 | 14.55 | 41 | 48734 | 8770 | 32455981 |
Intestinal infarction | 18.05 | 14.55 | 11 | 48764 | 554 | 32464197 |
Mesenteric haemorrhage | 17.98 | 14.55 | 4 | 48771 | 7 | 32464744 |
Factor V deficiency | 17.98 | 14.55 | 5 | 48770 | 29 | 32464722 |
Rectal cancer | 17.92 | 14.55 | 20 | 48755 | 2377 | 32462374 |
Haemoperitoneum | 17.91 | 14.55 | 17 | 48758 | 1670 | 32463081 |
Hypertension | 17.83 | 14.55 | 120 | 48655 | 131630 | 32333121 |
Loss of personal independence in daily activities | 17.78 | 14.55 | 9 | 48766 | 26824 | 32437927 |
Diverticulum | 17.71 | 14.55 | 35 | 48740 | 6947 | 32457804 |
Colitis ischaemic | 17.65 | 14.55 | 33 | 48742 | 6287 | 32458464 |
Splenic injury | 17.56 | 14.55 | 5 | 48770 | 32 | 32464719 |
Hyperglycaemia | 17.54 | 14.55 | 19 | 48756 | 38372 | 32426379 |
Pruritus | 17.53 | 14.55 | 117 | 48658 | 128585 | 32336166 |
Abdominal discomfort | 17.50 | 14.55 | 137 | 48638 | 52487 | 32412264 |
Therapy non-responder | 17.46 | 14.55 | 14 | 48761 | 32640 | 32432111 |
Lymphocyte count decreased | 17.46 | 14.55 | 5 | 48770 | 21114 | 32443637 |
Hypersensitivity | 17.35 | 14.55 | 38 | 48737 | 57720 | 32407031 |
Orthopaedic procedure | 17.31 | 14.55 | 4 | 48771 | 9 | 32464742 |
Puncture site haemorrhage | 17.25 | 14.55 | 9 | 48766 | 335 | 32464416 |
Confusional state | 17.13 | 14.55 | 135 | 48640 | 142980 | 32321771 |
Hyponatraemia | 17.11 | 14.55 | 56 | 48719 | 74457 | 32390294 |
Blood cholesterol increased | 17.09 | 14.55 | 3 | 48772 | 17754 | 32446997 |
Thrombotic cerebral infarction | 17.03 | 14.55 | 9 | 48766 | 344 | 32464407 |
Prothrombin time shortened | 16.79 | 14.55 | 16 | 48759 | 1580 | 32463171 |
Pain in extremity | 16.74 | 14.55 | 107 | 48668 | 118794 | 32345957 |
Eye haemorrhage | 16.69 | 14.55 | 25 | 48750 | 3972 | 32460779 |
Diverticulitis intestinal haemorrhagic | 16.65 | 14.55 | 9 | 48766 | 360 | 32464391 |
Blood lactate dehydrogenase increased | 16.54 | 14.55 | 6 | 48769 | 21799 | 32442952 |
Incarcerated inguinal hernia | 16.52 | 14.55 | 6 | 48769 | 90 | 32464661 |
Inguinal hernia strangulated | 16.51 | 14.55 | 3 | 48772 | 0 | 32464751 |
Pneumocystis jirovecii pneumonia | 16.49 | 14.55 | 4 | 48771 | 18866 | 32445885 |
Small intestinal haemorrhage | 16.44 | 14.55 | 18 | 48757 | 2094 | 32462657 |
Occult blood positive | 16.36 | 14.55 | 25 | 48750 | 4044 | 32460707 |
Cataract | 16.19 | 14.55 | 8 | 48767 | 24175 | 32440576 |
Gait disturbance | 16.09 | 14.55 | 64 | 48711 | 80344 | 32384407 |
Aortic dissection rupture | 16.02 | 14.55 | 4 | 48771 | 14 | 32464737 |
Internal haemorrhage | 16.01 | 14.55 | 27 | 48748 | 4745 | 32460006 |
Muscle strain | 15.99 | 14.55 | 24 | 48751 | 3821 | 32460930 |
Blood pressure increased | 15.99 | 14.55 | 63 | 48712 | 79291 | 32385460 |
Shock | 15.88 | 14.55 | 75 | 48700 | 24039 | 32440712 |
Peripheral ischaemia | 15.80 | 14.55 | 30 | 48745 | 5781 | 32458970 |
Tachycardia | 15.80 | 14.55 | 63 | 48712 | 79025 | 32385726 |
Influenza | 15.78 | 14.55 | 28 | 48747 | 45986 | 32418765 |
Encephalopathy | 15.60 | 14.55 | 17 | 48758 | 34240 | 32430511 |
Microvillous inclusion disease | 15.52 | 14.55 | 5 | 48770 | 51 | 32464700 |
Intentional product misuse | 15.22 | 14.55 | 19 | 48756 | 36032 | 32428719 |
Conjunctival haemorrhage | 15.11 | 14.55 | 20 | 48755 | 2835 | 32461916 |
Toxic epidermal necrolysis | 15.07 | 14.55 | 6 | 48769 | 20587 | 32444164 |
Post procedural pulmonary embolism | 15.05 | 14.55 | 4 | 48771 | 19 | 32464732 |
Gastritis erosive | 15.03 | 14.55 | 30 | 48745 | 5997 | 32458754 |
Serotonin syndrome | 14.95 | 14.55 | 5 | 48770 | 19112 | 32445639 |
Sleep disorder | 14.90 | 14.55 | 11 | 48764 | 26741 | 32438010 |
Cerebral thrombosis | 14.86 | 14.55 | 12 | 48763 | 950 | 32463801 |
Ulcer haemorrhage | 14.75 | 14.55 | 19 | 48756 | 2623 | 32462128 |
Monoparesis | 14.73 | 14.55 | 16 | 48759 | 1845 | 32462906 |
Thoracic haemorrhage | 14.71 | 14.55 | 7 | 48768 | 213 | 32464538 |
Source | Code | Description |
---|---|---|
ATC | B01AE07 | BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Direct thrombin inhibitors |
FDA MoA | N0000009963 | Thrombin Inhibitors |
FDA EPC | N0000175518 | Direct Thrombin Inhibitor |
MeSH PA | D000925 | Anticoagulants |
MeSH PA | D000991 | Antithrombins |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D006401 | Hematologic Agents |
MeSH PA | D011480 | Protease Inhibitors |
MeSH PA | D015842 | Serine Proteinase Inhibitors |
CHEBI has role | CHEBI:50249 | anticoagulante |
CHEBI has role | CHEBI:50266 | Prodrugs |
CHEBI has role | CHEBI:65232 | EC 3.4.21.5 inhibitor |
CHEBI has role | CHEBI:77020 | NRH:quinone oxidoreductase 2 inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Prevention of deep vein thrombosis | indication | 439993001 | |
Prevention of Thromboembolism with Chronic Atrial Fibrillation | indication | ||
Acute hemorrhage | contraindication | 8573003 | |
Acute nephropathy | contraindication | 58574008 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Anemia | contraindication | 271737000 | DOID:2355 |
Cerebral hemorrhage | contraindication | 274100004 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 5.35 | Basic |
pKa2 | 2.31 | Basic |
pKa3 | 1.61 | Basic |
pKa4 | 0.55 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
EQ 110MG BASE | PRADAXA | BOEHRINGER INGELHEIM | N022512 | Nov. 20, 2015 | RX | CAPSULE | ORAL | 9034822 | Jan. 20, 2031 | METHOD OF REVERSING THE ANTICOAGULANT EFFECT OF DABIGATRAN USING IDARUCIZUMAB |
EQ 150MG BASE | PRADAXA | BOEHRINGER INGELHEIM | N022512 | Oct. 19, 2010 | RX | CAPSULE | ORAL | 9034822 | Jan. 20, 2031 | METHOD OF REVERSING THE ANTICOAGULANT EFFECT OF DABIGATRAN USING IDARUCIZUMAB |
EQ 75MG BASE | PRADAXA | BOEHRINGER INGELHEIM | N022512 | Oct. 19, 2010 | RX | CAPSULE | ORAL | 9034822 | Jan. 20, 2031 | METHOD OF REVERSING THE ANTICOAGULANT EFFECT OF DABIGATRAN USING IDARUCIZUMAB |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
EQ 110MG BASE | PRADAXA | BOEHRINGER INGELHEIM | N022512 | Nov. 20, 2015 | RX | CAPSULE | ORAL | June 21, 2024 | TREATMENT OF VENOUS THROMBOEMBOLIC EVENTS (VTE) IN PEDIATRIC PATIENTS 8 TO LESS THAN 18 YEARS OF AGE WHO HAVE BEEN TREATED WITH A PARENTERAL ANTICOAGULANT FOR AT LEAST 5 DAYS AND TO REDUCE THE RISK OF RECURRENCE OF VTE IN PEDIATRIC PATIENTS 8 TO LESS THAN 18 YEARS OF AGE WHO HAVE BEEN PREVIOUSLY TREATED |
EQ 150MG BASE | PRADAXA | BOEHRINGER INGELHEIM | N022512 | Oct. 19, 2010 | RX | CAPSULE | ORAL | June 21, 2024 | TREATMENT OF VENOUS THROMBOEMBOLIC EVENTS (VTE) IN PEDIATRIC PATIENTS 8 TO LESS THAN 18 YEARS OF AGE WHO HAVE BEEN TREATED WITH A PARENTERAL ANTICOAGULANT FOR AT LEAST 5 DAYS AND TO REDUCE THE RISK OF RECURRENCE OF VTE IN PEDIATRIC PATIENTS 8 TO LESS THAN 18 YEARS OF AGE WHO HAVE BEEN PREVIOUSLY TREATED |
EQ 75MG BASE | PRADAXA | BOEHRINGER INGELHEIM | N022512 | Oct. 19, 2010 | RX | CAPSULE | ORAL | June 21, 2024 | TREATMENT OF VENOUS THROMBOEMBOLIC EVENTS (VTE) IN PEDIATRIC PATIENTS 8 TO LESS THAN 18 YEARS OF AGE WHO HAVE BEEN TREATED WITH A PARENTERAL ANTICOAGULANT FOR AT LEAST 5 DAYS AND TO REDUCE THE RISK OF RECURRENCE OF VTE IN PEDIATRIC PATIENTS 8 TO LESS THAN 18 YEARS OF AGE WHO HAVE BEEN PREVIOUSLY TREATED |
EQ 110MG BASE/PACKET | PRADAXA | BOEHRINGER INGELHEIM | N214358 | June 21, 2021 | RX | PELLETS | ORAL | June 21, 2024 | NEW PRODUCT |
EQ 150MG BASE/PACKET | PRADAXA | BOEHRINGER INGELHEIM | N214358 | June 21, 2021 | RX | PELLETS | ORAL | June 21, 2024 | NEW PRODUCT |
EQ 20MG BASE/PACKET | PRADAXA | BOEHRINGER INGELHEIM | N214358 | June 21, 2021 | RX | PELLETS | ORAL | June 21, 2024 | NEW PRODUCT |
EQ 30MG BASE/PACKET | PRADAXA | BOEHRINGER INGELHEIM | N214358 | June 21, 2021 | RX | PELLETS | ORAL | June 21, 2024 | NEW PRODUCT |
EQ 40MG BASE/PACKET | PRADAXA | BOEHRINGER INGELHEIM | N214358 | June 21, 2021 | RX | PELLETS | ORAL | June 21, 2024 | NEW PRODUCT |
EQ 50MG BASE/PACKET | PRADAXA | BOEHRINGER INGELHEIM | N214358 | June 21, 2021 | RX | PELLETS | ORAL | June 21, 2024 | NEW PRODUCT |
EQ 110MG BASE | PRADAXA | BOEHRINGER INGELHEIM | N022512 | Nov. 20, 2015 | RX | CAPSULE | ORAL | Dec. 21, 2024 | PEDIATRIC EXCLUSIVITY |
EQ 150MG BASE | PRADAXA | BOEHRINGER INGELHEIM | N022512 | Oct. 19, 2010 | RX | CAPSULE | ORAL | Dec. 21, 2024 | PEDIATRIC EXCLUSIVITY |
EQ 75MG BASE | PRADAXA | BOEHRINGER INGELHEIM | N022512 | Oct. 19, 2010 | RX | CAPSULE | ORAL | Dec. 21, 2024 | PEDIATRIC EXCLUSIVITY |
EQ 110MG BASE/PACKET | PRADAXA | BOEHRINGER INGELHEIM | N214358 | June 21, 2021 | RX | PELLETS | ORAL | Dec. 21, 2024 | PEDIATRIC EXCLUSIVITY |
EQ 150MG BASE/PACKET | PRADAXA | BOEHRINGER INGELHEIM | N214358 | June 21, 2021 | RX | PELLETS | ORAL | Dec. 21, 2024 | PEDIATRIC EXCLUSIVITY |
EQ 20MG BASE/PACKET | PRADAXA | BOEHRINGER INGELHEIM | N214358 | June 21, 2021 | RX | PELLETS | ORAL | Dec. 21, 2024 | PEDIATRIC EXCLUSIVITY |
EQ 30MG BASE/PACKET | PRADAXA | BOEHRINGER INGELHEIM | N214358 | June 21, 2021 | RX | PELLETS | ORAL | Dec. 21, 2024 | PEDIATRIC EXCLUSIVITY |
EQ 40MG BASE/PACKET | PRADAXA | BOEHRINGER INGELHEIM | N214358 | June 21, 2021 | RX | PELLETS | ORAL | Dec. 21, 2024 | PEDIATRIC EXCLUSIVITY |
EQ 50MG BASE/PACKET | PRADAXA | BOEHRINGER INGELHEIM | N214358 | June 21, 2021 | RX | PELLETS | ORAL | Dec. 21, 2024 | PEDIATRIC EXCLUSIVITY |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Prothrombin | Enzyme | INHIBITOR | Ki | 8.35 | CHEMBL | CHEMBL | |||
Plasminogen | Enzyme | Ki | 5.77 | CHEMBL | |||||
Coagulation factor X | Enzyme | Ki | 5.42 | CHEMBL | |||||
Tissue-type plasminogen activator | Enzyme | Ki | 4.34 | CHEMBL | |||||
Vitamin K-dependent protein C | Enzyme | Ki | 4.68 | CHEMBL | |||||
Solute carrier family 22 member 2 | Transporter | IC50 | 5.33 | CHEMBL | |||||
Multidrug and toxin extrusion protein 1 | Transporter | IC50 | 5.09 | CHEMBL | |||||
Multidrug and toxin extrusion protein 2 | Transporter | IC50 | 4.60 | CHEMBL | |||||
Trypsin | Enzyme | Ki | 7.30 | CHEMBL | |||||
Serine protease hepsin | Enzyme | Ki | 6.08 | CHEMBL | |||||
Ribosyldihydronicotinamide dehydrogenase [quinone] | Enzyme | IC50 | 4.96 | CHEMBL | |||||
Thrombin | Unclassified | IC50 | 6.26 | CHEMBL |
ID | Source |
---|---|
4030255 | VUID |
N0000181837 | NUI |
D07082 | KEGG_DRUG |
872728-81-9 | SECONDARY_CAS_RN |
211914-51-1 | SECONDARY_CAS_RN |
C1571583 | UMLSCUI |
CHEBI:70746 | CHEBI |
CHEBI:70752 | CHEBI |
CHEMBL539697 | ChEMBL_ID |
CHEMBL1615369 | ChEMBL_ID |
CHEMBL48361 | ChEMBL_ID |
D000069604 | MESH_DESCRIPTOR_UI |
DB06695 | DRUGBANK_ID |
6379 | IUPHAR_LIGAND_ID |
6380 | IUPHAR_LIGAND_ID |
8028 | INN_ID |
8027 | INN_ID |
2E18WX195X | UNII |
135565674 | PUBCHEM_CID |
216210 | PUBCHEM_CID |
DB14726 | DRUGBANK_ID |
I0VM4M70GC | UNII |
1037041 | RXNORM |
136711 | MMSL |
25762 | MMSL |
d07137 | MMSL |
012668 | NDDF |
012669 | NDDF |
698871007 | SNOMEDCT_US |
700029008 | SNOMEDCT_US |
700039002 | SNOMEDCT_US |
714788005 | SNOMEDCT_US |
4030254 | VANDF |
4030255 | VANDF |
C2348066 | UMLSCUI |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Pradaxa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0108 | CAPSULE | 110 mg | ORAL | NDA | 33 sections |
Pradaxa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0355 | CAPSULE | 75 mg | ORAL | NDA | 33 sections |
Pradaxa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0360 | CAPSULE | 150 mg | ORAL | NDA | 33 sections |
Pradaxa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0425 | PELLET | 20 mg | ORAL | NDA | 33 sections |
Pradaxa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0430 | PELLET | 30 mg | ORAL | NDA | 33 sections |
Pradaxa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0435 | PELLET | 40 mg | ORAL | NDA | 33 sections |
Pradaxa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0440 | PELLET | 50 mg | ORAL | NDA | 33 sections |
Pradaxa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0445 | PELLET | 110 mg | ORAL | NDA | 33 sections |
Pradaxa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0450 | PELLET | 150 mg | ORAL | NDA | 33 sections |
PRADAXA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-899 | CAPSULE | 150 mg | ORAL | NDA | 27 sections |
Pradaxa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3617 | CAPSULE | 150 mg | ORAL | NDA | 32 sections |
Pradaxa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4480 | CAPSULE | 150 mg | ORAL | NDA | 31 sections |
Pradaxa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-8242 | CAPSULE | 150 mg | ORAL | NDA | 32 sections |