dabigatran etexilate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
thrombin inhibitors, antithrombotic agents	776	211915-06-9

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: BIBR 1048 BIBR-1048 dabigatran etexilate mesilate dabigatran etexilate pradaxa dabigatran etexilate mesylate dabigatran etexilate methanesulfonate

A THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation. Molecular weight: 627.75 Formula: C34H41N7O5 CLOGP: 4.71 LIPINSKI: 2 HAC: 12 HDO: 3 TPSA: 151.53 ALOGS: -4.68 ROTB: 17 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
0.30	g	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	1.80 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	6.83 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

Date	Agency	Company	Orphan
Oct. 19, 2010	FDA	BOEHRINGER INGELHEIM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Gastrointestinal haemorrhage	4123.00	15.14	1781	39627	75592	46569062
Ischaemic stroke	2131.43	15.14	729	40679	15993	46628661
Cerebrovascular accident	1351.18	15.14	933	40475	100106	46544548
Haemorrhage	1121.87	15.14	663	40745	54206	46590448
Rectal haemorrhage	949.88	15.14	525	40883	37730	46606924
Melaena	939.96	15.14	469	40939	27303	46617351
Haemorrhage intracranial	850.97	15.14	346	41062	12378	46632276
Cerebral haemorrhage	651.20	15.14	370	41038	28001	46616653
Lower gastrointestinal haemorrhage	626.33	15.14	238	41170	7082	46637572
Activated partial thromboplastin time prolonged	564.33	15.14	217	41191	6672	46637982
Subdural haematoma	417.32	15.14	212	41196	12785	46631869
Cerebral infarction	411.47	15.14	257	41151	23109	46621545
Cardiac tamponade	399.73	15.14	150	41258	4304	46640350
Embolic stroke	368.73	15.14	134	41274	3505	46641149
Shock haemorrhagic	346.65	15.14	164	41244	8460	46636194
Blood loss anaemia	344.80	15.14	163	41245	8394	46636260
Haematoma	341.40	15.14	258	41150	31614	46613040
International normalised ratio increased	325.35	15.14	295	41113	46588	46598066
Haematochezia	314.77	15.14	263	41145	37230	46607424
Coagulopathy	311.93	15.14	198	41210	18301	46626353
Upper gastrointestinal haemorrhage	309.59	15.14	190	41218	16548	46628106
Fall	301.63	15.14	800	40608	328297	46316357
Transient ischaemic attack	274.84	15.14	236	41172	34667	46609987
Haemorrhagic stroke	267.99	15.14	120	41288	5446	46639208
Haematuria	266.96	15.14	208	41200	26650	46618004
Pericardial haemorrhage	250.57	15.14	81	41327	1470	46643184
Atrial thrombosis	235.68	15.14	76	41332	1368	46643286
Anaemia	225.01	15.14	613	40795	255166	46389488
Haematemesis	211.09	15.14	187	41221	28619	46616035
Thrombin time prolonged	205.78	15.14	40	41368	57	46644597
Subarachnoid haemorrhage	204.67	15.14	126	41282	11027	46633627
Intestinal haemorrhage	192.27	15.14	80	41328	3028	46641626
Deep vein thrombosis	191.85	15.14	291	41117	79482	46565172
Pulmonary embolism	175.86	15.14	332	41076	108253	46536401
Acute kidney injury	167.56	15.14	524	40884	235331	46409323
Rheumatoid arthritis	167.03	15.14	12	41396	240203	46404451
Haemoglobin decreased	166.75	15.14	359	41049	128590	46516064
Pain	164.70	15.14	111	41297	476837	46167817
Atrial fibrillation	160.67	15.14	311	41097	103279	46541375
Hemiparesis	158.52	15.14	136	41272	19933	46624721
Hypovolaemic shock	147.50	15.14	78	41330	5105	46639549
Drug hypersensitivity	146.75	15.14	21	41387	243804	46400850
Epistaxis	142.55	15.14	226	41182	64079	46580575
Renal failure	138.57	15.14	309	41099	113285	46531369
Subdural haemorrhage	137.68	15.14	62	41346	2850	46641804
Aortic dissection	122.70	15.14	48	41360	1544	46643110
Creatinine renal clearance decreased	121.44	15.14	76	41332	6844	46637810
Procoagulant therapy	114.55	15.14	19	41389	0	46644654
Cardiac failure	109.50	15.14	228	41180	79720	46564934
Wound secretion	109.30	15.14	58	41350	3822	46640832
Fatigue	104.78	15.14	242	41166	608455	46036199
Hemiplegia	103.98	15.14	69	41339	6869	46637785
Renal impairment	102.90	15.14	213	41195	74159	46570495
Haemothorax	101.79	15.14	45	41363	1979	46642675
Peripheral embolism	101.78	15.14	39	41369	1185	46643469
Prothrombin time prolonged	101.16	15.14	77	41331	9519	46635135
Haemoptysis	98.76	15.14	119	41289	26070	46618584
Procedural haemorrhage	97.77	15.14	46	41362	2340	46642314
Pyrexia	96.97	15.14	100	41308	348702	46295952
Coagulation time prolonged	92.12	15.14	37	41371	1277	46643377
Cerebral haematoma	91.49	15.14	49	41359	3290	46641364
Gastric haemorrhage	88.89	15.14	59	41349	5875	46638779
Head injury	86.51	15.14	108	41300	24528	46620126
Haemorrhoidal haemorrhage	83.84	15.14	48	41360	3672	46640982
Dyspepsia	83.11	15.14	186	41222	68286	46576368
Large intestinal haemorrhage	82.76	15.14	33	41375	1117	46643537
Maternal exposure during pregnancy	77.81	15.14	3	41405	102546	46542108
Toxicity to various agents	77.35	15.14	46	41362	211720	46432934
Post procedural haemorrhage	76.98	15.14	59	41349	7367	46637287
Anxiety	76.21	15.14	33	41375	181924	46462730
Haemorrhagic transformation stroke	75.35	15.14	31	41377	1139	46643515
Faeces discoloured	74.56	15.14	83	41325	16704	46627950
Depression	74.23	15.14	29	41379	170075	46474579
Rash	72.88	15.14	128	41280	356384	46288270
Arthralgia	72.66	15.14	133	41275	364470	46280184
Injection site pain	72.56	15.14	6	41402	107146	46537508
Traumatic haemorrhage	72.48	15.14	23	41385	392	46644262
Nausea	72.04	15.14	340	41068	687114	45957540
Aphasia	69.69	15.14	105	41303	28462	46616192
Drug ineffective	68.24	15.14	340	41068	677498	45967156
Headache	67.15	15.14	210	41198	478142	46166512
Thrombin time abnormal	66.32	15.14	11	41397	0	46644654
Embolism	65.97	15.14	53	41355	7085	46637569
Pericardial effusion	65.34	15.14	96	41312	25447	46619207
International normalised ratio abnormal	65.03	15.14	38	41370	3021	46641633
Mouth haemorrhage	64.75	15.14	50	41358	6312	46638342
Cerebral artery occlusion	63.91	15.14	26	41382	928	46643726
Pulmonary haemorrhage	63.76	15.14	50	41358	6455	46638199
Neutropenia	63.15	15.14	24	41384	143180	46501474
Nasopharyngitis	62.79	15.14	29	41379	153969	46490685
Splenic rupture	61.23	15.14	27	41381	1180	46643474
Product dose omission issue	60.96	15.14	37	41371	168483	46476171
Musculoskeletal stiffness	59.91	15.14	8	41400	97985	46546669
Activated partial thromboplastin time abnormal	58.85	15.14	15	41393	109	46644545
Condition aggravated	58.63	15.14	79	41329	244973	46399681
International normalised ratio	57.82	15.14	14	41394	80	46644574
Gingival bleeding	57.72	15.14	61	41347	11578	46633076
Intestinal ischaemia	56.85	15.14	48	41360	6877	46637777
Thrombosis	56.82	15.14	142	41266	55927	46588727
Cardiac valve replacement complication	56.78	15.14	16	41392	177	46644477
Craniocerebral injury	56.69	15.14	31	41377	2169	46642485
Infusion related reaction	55.75	15.14	11	41397	101197	46543457
Contusion	55.22	15.14	187	41221	87300	46557354
Intra-abdominal haemorrhage	55.03	15.14	31	41377	2299	46642355
Weight increased	54.26	15.14	40	41368	164433	46480221
Hip fracture	54.25	15.14	90	41318	26466	46618188
Drug intolerance	53.58	15.14	32	41376	147017	46497637
Sinusitis	53.57	15.14	24	41384	129744	46514910
Cerebral artery embolism	53.48	15.14	22	41386	808	46643846
Intracardiac thrombus	52.60	15.14	30	41378	2278	46642376
Drug interaction	51.41	15.14	332	41076	202762	46441892
Peripheral ischaemia	51.20	15.14	38	41370	4521	46640133
Puncture site haemorrhage	50.79	15.14	16	41392	266	46644388
Retroperitoneal haemorrhage	50.47	15.14	31	41377	2699	46641955
Iron deficiency anaemia	50.40	15.14	69	41339	17137	46627517
Colon cancer	50.32	15.14	51	41357	9218	46635436
Cerebral ischaemia	50.20	15.14	43	41365	6282	46638372
Therapeutic product effect decreased	49.88	15.14	7	41401	82594	46562060
Blood urine present	48.25	15.14	57	41351	12225	46632429
Back pain	47.94	15.14	70	41338	209969	46434685
Chills	47.80	15.14	13	41395	96019	46548635
Joint swelling	46.73	15.14	47	41361	166026	46478628
Acute abdomen	46.28	15.14	24	41384	1508	46643146
Neuropathy peripheral	43.95	15.14	13	41395	90880	46553774
Anticoagulation drug level increased	43.94	15.14	13	41395	173	46644481
Product use issue	43.17	15.14	15	41393	94629	46550025
Treatment failure	42.04	15.14	15	41393	93072	46551582
Peripheral swelling	41.94	15.14	47	41361	158024	46486630
Gastritis erosive	41.82	15.14	36	41372	5294	46639360
Embolic cerebral infarction	41.82	15.14	16	41392	484	46644170
Hypersensitivity	41.77	15.14	43	41365	150278	46494376
Multiple organ dysfunction syndrome	41.35	15.14	120	41288	51590	46593064
Arthropathy	41.16	15.14	12	41396	84688	46559966
Disease progression	40.74	15.14	15	41393	91285	46553369
Haemarthrosis	40.63	15.14	28	41380	2965	46641689
Shock	40.61	15.14	71	41337	21774	46622880
Haemoperitoneum	40.40	15.14	26	41382	2456	46642198
Traumatic intracranial haemorrhage	40.16	15.14	14	41394	323	46644331
Acute myocardial infarction	40.15	15.14	88	41320	31836	46612818
Peripheral artery thrombosis	39.85	15.14	23	41385	1786	46642868
Drug abuse	39.17	15.14	5	41403	63403	46581251
Haemorrhage subcutaneous	39.01	15.14	27	41381	2879	46641775
Haemorrhagic cerebral infarction	38.84	15.14	16	41392	590	46644064
Systemic lupus erythematosus	38.25	15.14	6	41402	65174	46579480
Strangulated hernia	38.17	15.14	9	41399	45	46644609
Influenza	37.64	15.14	16	41392	89254	46555400
Vaginal haemorrhage	37.35	15.14	75	41333	25529	46619125
Colitis ischaemic	36.49	15.14	45	41363	10087	46634567
Hypocoagulable state	36.29	15.14	18	41390	1029	46643625
Intraventricular haemorrhage	36.16	15.14	22	41386	1883	46642771
Cardiac perforation	35.98	15.14	9	41399	60	46644594
Femoral neck fracture	35.87	15.14	40	41368	8063	46636591
Exsanguination	35.22	15.14	7	41401	12	46644642
Upper respiratory tract infection	34.80	15.14	7	41401	63549	46581105
Infection	34.05	15.14	41	41367	133551	46511103
Coagulation test abnormal	33.88	15.14	15	41393	662	46643992
Prothrombin time abnormal	33.65	15.14	13	41395	404	46644250
White blood cell count decreased	33.62	15.14	30	41378	112201	46532453
Diverticulum intestinal haemorrhagic	33.38	15.14	18	41390	1225	46643429
Ischaemic cerebral infarction	33.35	15.14	18	41390	1227	46643427
Skin haemorrhage	33.06	15.14	33	41375	5858	46638796
Skull fracture	33.01	15.14	16	41392	870	46643784
Diverticulum	32.91	15.14	45	41363	11161	46633493
Contraindicated product administered	32.65	15.14	15	41393	79932	46564722
Prothrombin time shortened	32.58	15.14	20	41388	1739	46642915
Stress	32.00	15.14	4	41404	51547	46593107
Asthma	31.84	15.14	21	41387	91521	46553133
Subcutaneous haematoma	31.71	15.14	19	41389	1582	46643072
Mesenteric artery embolism	31.54	15.14	6	41402	7	46644647
Wound haemorrhage	31.50	15.14	21	41387	2106	46642548
Product use in unapproved indication	31.00	15.14	21	41387	90252	46554402
Hypochromic anaemia	30.96	15.14	18	41390	1417	46643237
Diarrhoea	30.76	15.14	333	41075	559269	46085385
Death	30.69	15.14	442	40966	335106	46309548
Coagulation factor increased	30.30	15.14	6	41402	10	46644644
Pelvic haematoma	30.28	15.14	13	41395	532	46644122
Psoriasis	30.20	15.14	16	41392	78588	46566066
Cough	30.16	15.14	104	41304	230145	46414509
Prothrombin time ratio decreased	29.99	15.14	12	41396	410	46644244
Insomnia	29.46	15.14	64	41344	164860	46479794
Post procedural haematoma	29.29	15.14	17	41391	1334	46643320
Ischaemia	29.01	15.14	27	41381	4397	46640257
Pruritus	28.78	15.14	114	41294	242238	46402416
Small intestinal haemorrhage	28.48	15.14	19	41389	1907	46642747
Constipation	28.34	15.14	71	41337	174026	46470628
Intracranial haematoma	28.17	15.14	11	41397	352	46644302
Paraesthesia	27.90	15.14	38	41370	117399	46527255
Neutrophil count decreased	27.87	15.14	3	41405	43423	46601231
Femoral artery embolism	27.69	15.14	7	41401	49	46644605
Therapeutic response decreased	27.64	15.14	3	41405	43142	46601512
Stomatitis	27.60	15.14	13	41395	68284	46576370
Oesophageal ulcer	27.58	15.14	25	41383	3936	46640718
Brain herniation	26.99	15.14	22	41386	3001	46641653
Gastric ulcer haemorrhage	26.82	15.14	27	41381	4841	46639813
Microcytic anaemia	26.52	15.14	22	41386	3076	46641578
Incarcerated hernia	26.22	15.14	8	41400	119	46644535
Ecchymosis	25.96	15.14	39	41369	10537	46634117
Oesophageal pain	25.91	15.14	20	41388	2523	46642131
Haematocrit decreased	25.78	15.14	79	41329	34978	46609676
Suicidal ideation	25.59	15.14	9	41399	56373	46588281
Phlebitis	25.40	15.14	29	41379	5997	46638657
Anticoagulation drug level above therapeutic	25.22	15.14	15	41393	1232	46643422
Influenza like illness	24.78	15.14	10	41398	57560	46587094
Intentional product use issue	24.70	15.14	8	41400	52772	46591882
Rhinorrhoea	24.58	15.14	6	41402	47659	46596995
Therapeutic product effect incomplete	24.49	15.14	20	41388	78133	46566521
Neurologic neglect syndrome	24.39	15.14	12	41396	674	46643980
Alopecia	24.33	15.14	69	41339	162345	46482309
Pain in extremity	24.03	15.14	133	41275	258547	46386107
Road traffic accident	23.98	15.14	60	41348	23631	46621023
Intentional overdose	23.82	15.14	14	41394	64930	46579724
Vomiting	23.82	15.14	272	41136	452522	46192132
Cardiac failure congestive	23.78	15.14	151	41257	91599	46553055
Intestinal infarction	23.40	15.14	13	41395	938	46643716
Hot flush	23.39	15.14	5	41403	43512	46601142
Swelling	23.33	15.14	47	41361	124464	46520190
Lower respiratory tract infection	23.02	15.14	10	41398	55079	46589575
Atrial flutter	22.84	15.14	34	41374	9114	46635540
Basal ganglia haemorrhage	22.81	15.14	11	41397	591	46644063
Pulmonary alveolar haemorrhage	22.77	15.14	23	41385	4139	46640515
Weight decreased	22.66	15.14	103	41305	210746	46433908
Dysphagia	22.42	15.14	131	41277	77181	46567473
Somnolence	22.35	15.14	68	41340	156453	46488201
Glossodynia	22.08	15.14	6	41402	44367	46600287
Petechiae	22.03	15.14	40	41368	12630	46632024
Occult blood positive	21.90	15.14	21	41387	3549	46641105
Gastritis haemorrhagic	21.85	15.14	14	41394	1312	46643342
Prothrombin time	21.73	15.14	5	41403	22	46644632
Injection site bruising	21.55	15.14	3	41405	35633	46609021
Disseminated intravascular coagulation	21.23	15.14	50	41358	18955	46625699
Conjunctival haemorrhage	21.12	15.14	19	41389	2962	46641692
Occult blood	21.08	15.14	12	41396	908	46643746
Mobility decreased	20.93	15.14	14	41394	60580	46584074
Haemorrhage urinary tract	20.85	15.14	11	41397	716	46643938
Pelvic fracture	20.79	15.14	37	41371	11502	46633152
Gastric ulcer	20.71	15.14	54	41354	21809	46622845
Haemorrhagic arteriovenous malformation	20.69	15.14	7	41401	147	46644507
Brain contusion	20.59	15.14	10	41398	546	46644108
Haemorrhoids	20.55	15.14	49	41359	18728	46625926
Hypoaesthesia	20.50	15.14	47	41361	118822	46525832
Herpes zoster	20.49	15.14	18	41390	67854	46576800
Multiple sclerosis relapse	20.40	15.14	6	41402	42119	46602535
Renal infarct	20.34	15.14	13	41395	1214	46643440
Gastrointestinal necrosis	20.04	15.14	18	41390	2800	46641854
Malignant neoplasm progression	19.87	15.14	17	41391	64909	46579745
Prothrombin level decreased	19.71	15.14	10	41398	600	46644054
Nasal congestion	19.68	15.14	9	41399	48104	46596550
Heart transplant	19.60	15.14	9	41399	433	46644221
Post procedural haematuria	19.54	15.14	5	41403	37	46644617
Musculoskeletal pain	19.53	15.14	20	41388	70108	46574546
Splenic haematoma	19.43	15.14	6	41402	93	46644561
Osteoarthritis	19.27	15.14	16	41392	62009	46582645
Activated partial thromboplastin time	19.11	15.14	4	41404	10	46644644
Bronchitis	19.01	15.14	41	41367	105938	46538716
Thrombotic cerebral infarction	18.71	15.14	6	41402	106	46644548
Lacunar infarction	18.60	15.14	19	41389	3466	46641188
Cardioversion	18.58	15.14	12	41396	1140	46643514
Cardiac failure chronic	18.42	15.14	19	41389	3505	46641149
Haemoglobin abnormal	18.39	15.14	21	41387	4342	46640312
Hypotension	18.37	15.14	299	41109	232290	46412364
Cardiogenic shock	18.19	15.14	43	41365	16341	46628313
Spontaneous haematoma	18.12	15.14	10	41398	712	46643942
Thrombotic stroke	17.98	15.14	9	41399	525	46644129
Muscle spasms	17.92	15.14	53	41355	123060	46521594
Diverticulitis intestinal haemorrhagic	17.87	15.14	6	41402	123	46644531
Gastritis	17.86	15.14	69	41339	34309	46610345
Pancytopenia	17.80	15.14	30	41378	85028	46559626
Abdominal wall haematoma	17.77	15.14	17	41391	2864	46641790
Arteriovenous malformation	17.67	15.14	12	41396	1241	46643413
Aortic thrombosis	17.64	15.14	11	41397	984	46643670
Cardiac ablation	17.61	15.14	12	41396	1247	46643407
Gastric cancer	17.54	15.14	17	41391	2912	46641742
Haemorrhagic disorder	17.50	15.14	10	41398	762	46643892
Acute coronary syndrome	17.47	15.14	32	41376	10172	46634482
Blood glucose increased	17.40	15.14	23	41385	71990	46572664
Malaise	17.38	15.14	199	41209	331033	46313621
Leukopenia	17.38	15.14	21	41387	68322	46576332
Bone pain	17.35	15.14	10	41398	46880	46597774
Abdominal wall haemorrhage	17.31	15.14	6	41402	136	46644518
Rectal perforation	17.15	15.14	8	41400	399	46644255
Cerebellar haemorrhage	17.03	15.14	12	41396	1317	46643337
Urticaria	16.98	15.14	51	41357	117841	46526813
Infarction	16.96	15.14	15	41393	2286	46642368
Brain stem stroke	16.72	15.14	7	41401	269	46644385
Blood pressure increased	16.71	15.14	57	41351	126609	46518045
Hospitalisation	16.62	15.14	19	41389	63366	46581288
Myalgia	16.50	15.14	55	41353	123033	46521621
Oesophagitis	16.45	15.14	37	41371	13614	46631040
Arthritis	16.43	15.14	27	41381	77289	46567365
Mucosal inflammation	16.40	15.14	7	41401	38969	46605685
Arterial haemorrhage	16.39	15.14	13	41395	1705	46642949
Migraine	16.28	15.14	23	41385	70003	46574651
Embolism arterial	16.07	15.14	11	41397	1152	46643502
Tremor	15.97	15.14	51	41357	115588	46529066
Spinal cord haematoma	15.86	15.14	6	41402	176	46644478
Lymphadenopathy	15.80	15.14	5	41403	33483	46611171
Depressed mood	15.68	15.14	5	41403	33314	46611340
Polyp	15.63	15.14	21	41387	5122	46639532
Brain stem haemorrhage	15.42	15.14	9	41399	714	46643940
Agitation	15.21	15.14	16	41392	55399	46589255
Rib fracture	15.16	15.14	44	41364	18910	46625744
NIH stroke scale abnormal	15.15	15.14	3	41405	5	46644649

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Gastrointestinal haemorrhage	2703.88	14.08	1657	45364	81789	29823668
Ischaemic stroke	2168.80	14.08	852	46169	15423	29890034
Cerebrovascular accident	1529.59	14.08	1168	45853	82309	29823148
Haemorrhage	1057.84	14.08	740	46281	45339	29860118
Haemorrhage intracranial	846.40	14.08	431	46590	14601	29890856
Rectal haemorrhage	810.35	14.08	565	46456	34374	29871083
Cerebral infarction	804.33	14.08	506	46515	25867	29879590
Melaena	697.53	14.08	501	46520	31936	29873521
Cerebral haemorrhage	691.33	14.08	501	46520	32386	29873071
Atrial thrombosis	612.88	14.08	192	46829	1689	29903768
Embolic stroke	586.75	14.08	219	46802	3403	29902054
Subdural haematoma	555.66	14.08	355	46666	18617	29886840
Cardiac tamponade	503.44	14.08	210	46811	4434	29901023
Haematuria	412.74	14.08	426	46595	44408	29861049
Lower gastrointestinal haemorrhage	371.56	14.08	201	46820	7703	29897754
Transient ischaemic attack	368.55	14.08	310	46711	24890	29880567
Fall	367.35	14.08	851	46170	181021	29724436
Activated partial thromboplastin time prolonged	359.46	14.08	196	46825	7632	29897825
Shock haemorrhagic	304.66	14.08	191	46830	9674	29895783
Hemiparesis	291.45	14.08	217	46804	14585	29890872
Upper gastrointestinal haemorrhage	261.94	14.08	241	46780	21787	29883670
Blood loss anaemia	236.32	14.08	148	46873	7479	29897978
Deep vein thrombosis	223.49	14.08	366	46655	60135	29845322
Coagulopathy	211.53	14.08	198	46823	18289	29887168
Pericardial haemorrhage	206.86	14.08	98	46923	2820	29902637
Haemorrhagic stroke	204.96	14.08	125	46896	6022	29899435
Pulmonary embolism	199.88	14.08	403	46618	77732	29827725
Thrombin time prolonged	190.11	14.08	46	46975	128	29905329
Haematoma	187.41	14.08	209	46812	23744	29881713
Subarachnoid haemorrhage	183.62	14.08	140	46881	9746	29895711
Haemothorax	174.44	14.08	93	46928	3456	29902001
Aphasia	164.89	14.08	177	46844	19262	29886195
Aortic dissection	160.90	14.08	78	46943	2364	29903093
Toxicity to various agents	142.90	14.08	50	46971	177133	29728324
Epistaxis	139.83	14.08	277	46744	52704	29852753
Completed suicide	137.78	14.08	4	47017	99488	29805969
Head injury	133.95	14.08	149	46872	16871	29888586
Haematemesis	133.00	14.08	184	46837	26019	29879438
Pyrexia	132.45	14.08	161	46860	294328	29611129
Haematochezia	127.54	14.08	208	46813	34014	29871443
Hemiplegia	127.38	14.08	96	46925	6565	29898892
Procoagulant therapy	127.31	14.08	24	46997	4	29905453
Procedural haemorrhage	125.53	14.08	65	46956	2273	29903184
Haemorrhagic transformation stroke	124.89	14.08	53	46968	1168	29904289
Febrile neutropenia	121.52	14.08	13	47008	106680	29798777
Neutropenia	118.81	14.08	28	46993	128512	29776945
Haemoptysis	118.68	14.08	191	46830	30887	29874570
Subdural haemorrhage	110.33	14.08	64	46957	2808	29902649
Anaemia	108.92	14.08	626	46395	207366	29698091
Intracardiac thrombus	108.76	14.08	60	46961	2388	29903069
Intestinal haemorrhage	103.91	14.08	64	46957	3137	29902320
Cerebral haematoma	102.06	14.08	72	46949	4442	29901015
Peripheral embolism	99.63	14.08	41	46980	834	29904623
Post procedural haemorrhage	94.85	14.08	87	46934	7823	29897634
Brain contusion	93.49	14.08	38	46983	748	29904709
International normalised ratio increased	92.09	14.08	220	46801	47519	29857938
Pericardial effusion	90.53	14.08	137	46884	21007	29884450
Cardiac failure	87.57	14.08	309	46712	83109	29822348
Colon cancer	86.87	14.08	85	46936	8287	29897170
Product dose omission issue	86.55	14.08	19	47002	91612	29813845
Drug abuse	86.17	14.08	13	47008	82059	29823398
Fatigue	84.15	14.08	243	46778	320430	29585027
Oesophageal pain	81.01	14.08	34	46987	728	29904729
Large intestinal haemorrhage	76.78	14.08	41	46980	1528	29903929
Renal impairment	72.72	14.08	293	46728	83891	29821566
Anticoagulation drug level increased	71.76	14.08	28	46993	493	29904964
Disease progression	70.66	14.08	19	47002	79855	29825602
Faeces discoloured	69.34	14.08	97	46924	13849	29891608
Depression	68.66	14.08	28	46993	90409	29815048
Pancytopenia	68.46	14.08	24	46997	85028	29820429
Pain	67.71	14.08	104	46917	172537	29732920
Pulmonary haemorrhage	66.72	14.08	78	46943	9314	29896143
Gastric haemorrhage	66.22	14.08	78	46943	9389	29896068
Traumatic intracranial haemorrhage	66.06	14.08	28	46993	615	29904842
Blood urine present	65.03	14.08	79	46942	9821	29895636
Dyspepsia	64.19	14.08	145	46876	30184	29875273
Road traffic accident	63.89	14.08	104	46917	16967	29888490
Extradural haematoma	63.67	14.08	33	46988	1156	29904301
Nausea	63.45	14.08	246	46775	296711	29608746
Embolism	63.27	14.08	66	46955	6943	29898514
Diarrhoea	63.24	14.08	290	46731	333813	29571644
Drug hypersensitivity	63.11	14.08	15	47006	68504	29836953
Rash	61.46	14.08	131	46890	191758	29713699
Contusion	61.21	14.08	145	46876	31135	29874322
Cerebral artery occlusion	61.14	14.08	28	46993	744	29904713
Coagulation test abnormal	61.12	14.08	24	46997	430	29905027
Leukopenia	61.03	14.08	8	47013	56151	29849306
Gingival bleeding	60.87	14.08	62	46959	6342	29899115
Hypovolaemic shock	60.10	14.08	62	46959	6438	29899019
Product use in unapproved indication	58.95	14.08	21	47000	73672	29831785
Urinary bladder haemorrhage	58.71	14.08	35	46986	1616	29903841
White blood cell count decreased	57.50	14.08	30	46991	83917	29821540
Wound secretion	56.69	14.08	40	46981	2468	29902989
Intraventricular haemorrhage	56.44	14.08	43	46978	2987	29902470
Splenic rupture	55.76	14.08	33	46988	1503	29903954
Tremor	54.54	14.08	25	46996	75338	29830119
Coagulation time prolonged	54.14	14.08	30	46991	1204	29904253
Haemorrhagic infarction	54.01	14.08	21	47000	366	29905091
Skull fracture	53.27	14.08	27	46994	902	29904555
Insomnia	52.16	14.08	42	46979	93294	29812163
Embolic cerebral infarction	51.11	14.08	24	46997	676	29904781
Anorectal discomfort	50.66	14.08	33	46988	1784	29903673
Chills	49.31	14.08	26	46995	72312	29833145
Cardiac ablation	48.51	14.08	22	46999	571	29904886
Anxiety	47.10	14.08	43	46978	89828	29815629
Embolism arterial	46.92	14.08	21	47000	528	29904929
Rheumatoid arthritis	46.91	14.08	5	47016	41192	29864265
Traumatic haemorrhage	46.75	14.08	22	46999	623	29904834
Activated partial thromboplastin time abnormal	46.07	14.08	13	47008	76	29905381
Creatinine renal clearance decreased	45.99	14.08	40	46981	3353	29902104
Vomiting	45.65	14.08	184	46837	219634	29685823
Cerebral artery embolism	45.05	14.08	24	46997	890	29904567
Thrombosis	44.74	14.08	157	46864	42074	29863383
Aortic aneurysm rupture	44.32	14.08	25	46996	1039	29904418
Agitation	43.94	14.08	15	47006	54058	29851399
Infusion related reaction	43.54	14.08	6	47015	40558	29864899
Condition aggravated	43.37	14.08	95	46926	137771	29767686
Neuropathy peripheral	42.88	14.08	29	46992	70446	29835011
Traumatic haemothorax	41.14	14.08	15	47006	217	29905240
Haemoglobin decreased	40.45	14.08	312	46709	113786	29791671
Haemorrhoidal haemorrhage	40.42	14.08	36	46985	3114	29902343
Surgery	40.04	14.08	68	46953	11483	29893974
Atrial fibrillation	39.64	14.08	298	46723	107826	29797631
Weight increased	39.06	14.08	36	46985	74877	29830580
Renal failure	38.92	14.08	340	46681	128626	29776831
Basal ganglia haemorrhage	37.92	14.08	21	47000	842	29904615
Seizure	37.90	14.08	60	46961	98415	29807042
Psoriasis	37.78	14.08	10	47011	42496	29862961
Renal infarct	37.73	14.08	23	46998	1106	29904351
Neutrophil count decreased	37.71	14.08	10	47011	42444	29863013
Intra-abdominal haemorrhage	37.34	14.08	29	46992	2073	29903384
International normalised ratio	37.25	14.08	10	47011	47	29905410
Alanine aminotransferase increased	37.20	14.08	37	46984	74239	29831218
Acute abdomen	37.17	14.08	27	46994	1744	29903713
Incarcerated hernia	36.78	14.08	13	47008	171	29905286
Muscle spasms	36.43	14.08	29	46992	64809	29840648
Somnolence	36.26	14.08	60	46961	96703	29808754
Mouth haemorrhage	36.19	14.08	42	46979	4975	29900482
Aggression	36.17	14.08	7	47014	36900	29868557
Blood creatine phosphokinase increased	35.91	14.08	12	47009	43836	29861621
Heart transplant	35.62	14.08	17	47004	497	29904960
Cerebellar haemorrhage	35.52	14.08	24	46997	1380	29904077
Arthralgia	35.38	14.08	103	46918	135688	29769769
Oesophageal ulcer	35.36	14.08	34	46987	3243	29902214
Product use issue	35.30	14.08	14	47007	46002	29859455
Malignant neoplasm progression	35.08	14.08	37	46984	72250	29833207
Retroperitoneal haemorrhage	34.78	14.08	31	46990	2684	29902773
Pulmonary alveolar haemorrhage	34.55	14.08	47	46974	6534	29898923
Platelet count decreased	34.30	14.08	72	46949	106057	29799400
Haemorrhage urinary tract	34.02	14.08	25	46996	1644	29903813
Mucosal inflammation	33.96	14.08	4	47017	30490	29874967
Intentional product use issue	33.49	14.08	8	47013	36432	29869025
Cardiac valve replacement complication	33.24	14.08	9	47012	44	29905413
Arterial thrombosis	33.12	14.08	23	46998	1383	29904074
Erythema	32.93	14.08	44	46977	77407	29828050
Dysarthria	32.84	14.08	114	46907	30376	29875081
Thrombin time abnormal	32.75	14.08	6	47015	0	29905457
Activated partial thromboplastin time	32.75	14.08	6	47015	0	29905457
Creatinine renal clearance	32.75	14.08	6	47015	0	29905457
International normalised ratio abnormal	32.74	14.08	32	46989	3114	29902343
Femoral neck fracture	32.65	14.08	31	46990	2911	29902546
Strangulated hernia	32.44	14.08	7	47014	9	29905448
Gastrointestinal carcinoma	32.40	14.08	20	47001	984	29904473
Oesophageal carcinoma	32.27	14.08	32	46989	3169	29902288
Coagulation time shortened	31.41	14.08	12	47009	199	29905258
Acute kidney injury	31.26	14.08	603	46418	273239	29632218
Appendicitis	30.93	14.08	43	46978	6101	29899356
Intracranial haematoma	30.40	14.08	14	47007	377	29905080
Weight decreased	30.24	14.08	128	46893	150793	29754664
Wound haemorrhage	30.20	14.08	24	46997	1774	29903683
Cough	30.10	14.08	99	46922	125543	29779914
Gastric cancer	30.10	14.08	38	46983	4912	29900545
Cardioversion	29.86	14.08	18	47003	848	29904609
Drug intolerance	29.81	14.08	17	47004	45274	29860183
Large intestine polyp	29.45	14.08	44	46977	6665	29898792
Neurologic neglect syndrome	29.44	14.08	11	47010	171	29905286
Gastrointestinal motility disorder	29.43	14.08	26	46995	2225	29903232
Blood glucose increased	29.29	14.08	32	46989	61498	29843959
Stomatitis	29.16	14.08	11	47010	37268	29868189
C-reactive protein increased	29.07	14.08	16	47005	43457	29862000
White blood cell count increased	28.94	14.08	13	47008	39660	29865797
Hemianopia	28.70	14.08	16	47005	650	29904807
Elderly	28.60	14.08	6	47015	6	29905451
Urogenital haemorrhage	28.54	14.08	11	47010	187	29905270
Cardiac perforation	28.53	14.08	9	47012	81	29905376
Aspartate aminotransferase increased	28.02	14.08	35	46986	63387	29842070
Ischaemia	27.95	14.08	35	46986	4486	29900971
Multiple injuries	27.89	14.08	24	46997	1983	29903474
Iron deficiency anaemia	27.24	14.08	50	46971	8974	29896483
Post procedural stroke	27.19	14.08	7	47014	27	29905430
Plasma cell myeloma	26.34	14.08	27	46994	53435	29852022
Asthma	26.16	14.08	12	47009	36162	29869295
Craniocerebral injury	26.15	14.08	27	46994	2806	29902651
Anaphylactic reaction	26.00	14.08	6	47015	27976	29877481
Rib fracture	26.00	14.08	60	46961	12660	29892797
Infarction	25.98	14.08	26	46995	2604	29902853
Peripheral artery thrombosis	25.69	14.08	24	46997	2208	29903249
Haemorrhage subcutaneous	25.64	14.08	24	46997	2213	29903244
Off label use	25.63	14.08	259	46762	249031	29656426
Cerebellar infarction	25.47	14.08	22	46999	1827	29903630
Nasopharyngitis	25.45	14.08	33	46988	58816	29846641
Acute myocardial infarction	25.40	14.08	156	46865	52783	29852674
Injection site pain	25.34	14.08	8	47013	30302	29875155
Therapeutic response decreased	25.21	14.08	4	47017	24345	29881112
Rhabdomyolysis	25.16	14.08	38	46983	63542	29841915
Joint swelling	25.13	14.08	22	46999	46924	29858533
Diverticulum intestinal haemorrhagic	25.03	14.08	23	46998	2072	29903385
Exsanguination	24.94	14.08	7	47014	40	29905417
Prothrombin time prolonged	24.93	14.08	49	46972	9254	29896203
Thrombotic stroke	24.82	14.08	11	47010	270	29905187
Abnormal behaviour	24.81	14.08	5	47016	25618	29879839
Ecchymosis	24.76	14.08	40	46981	6482	29898975
Intestinal ischaemia	24.43	14.08	41	46980	6856	29898601
Arteriovenous malformation	24.36	14.08	14	47007	603	29904854
Infection	24.35	14.08	54	46967	78020	29827437
Electrocardiogram QT prolonged	24.23	14.08	13	47008	35822	29869635
Sinusitis	24.21	14.08	11	47010	33334	29872123
Femur fracture	23.98	14.08	42	46979	7267	29898190
Hyperhidrosis	23.84	14.08	43	46978	67047	29838410
Skin haemorrhage	23.49	14.08	28	46993	3412	29902045
Thrombocytopenia	23.46	14.08	123	46898	136921	29768536
Irritability	23.39	14.08	4	47017	23046	29882411
Feeling abnormal	23.36	14.08	33	46988	56723	29848734
Pulmonary contusion	23.03	14.08	7	47014	55	29905402
Ascites	22.90	14.08	14	47007	35907	29869550
Back pain	22.44	14.08	84	46937	102512	29802945
Hemianopia homonymous	22.31	14.08	14	47007	709	29904748
Colon neoplasm	22.16	14.08	11	47010	351	29905106
Cerebral ischaemia	22.15	14.08	37	46984	6163	29899294
Cholecystitis acute	22.11	14.08	34	46987	5283	29900174
Mesenteric artery embolism	22.09	14.08	7	47014	64	29905393
Diabetes mellitus	21.95	14.08	20	47001	41845	29863612
Cerebral vascular occlusion	21.83	14.08	4	47017	0	29905457
Dyskinesia	21.69	14.08	4	47017	21830	29883627
Aneurysm ruptured	21.65	14.08	12	47009	482	29904975
Herpes zoster	21.54	14.08	10	47011	29933	29875524
Musculoskeletal stiffness	21.50	14.08	15	47006	35866	29869591
Ischaemic cerebral infarction	21.42	14.08	15	47006	914	29904543
Gastrointestinal angiodysplasia	21.38	14.08	12	47009	494	29904963
Subarachnoid haematoma	21.27	14.08	7	47014	73	29905384
Thalamus haemorrhage	21.01	14.08	15	47006	943	29904514
Influenza like illness	20.97	14.08	7	47014	25598	29879859
Renal haemorrhage	20.91	14.08	17	47004	1298	29904159
Subcutaneous haematoma	20.87	14.08	15	47006	953	29904504
Myalgia	20.80	14.08	57	46964	76610	29828847
Pneumonia	20.75	14.08	385	46636	333921	29571536
Vision blurred	20.73	14.08	21	47000	41795	29863662
Gastric ulcer haemorrhage	20.73	14.08	33	46988	5281	29900176
Hyperglycaemia	20.72	14.08	15	47006	35185	29870272
Lumbar puncture	20.62	14.08	7	47014	81	29905376
Haemoglobin abnormal	20.60	14.08	25	46996	3104	29902353
Haemorrhoids	20.28	14.08	53	46968	12088	29893369
Brain herniation	20.07	14.08	27	46994	3713	29901744
Productive cough	20.06	14.08	11	47010	29942	29875515
Hospitalisation	20.05	14.08	24	46997	44295	29861162
Coronary artery embolism	19.94	14.08	8	47013	152	29905305
Venous thrombosis	19.94	14.08	25	46996	3209	29902248
Hypertension	19.62	14.08	111	46910	121243	29784214
Stress	19.49	14.08	4	47017	20231	29885226
Osteonecrosis of jaw	19.41	14.08	3	47018	18615	29886842
Urticaria	19.40	14.08	35	46986	54571	29850886
Haemoperitoneum	19.31	14.08	17	47004	1448	29904009
Factor V deficiency	19.28	14.08	5	47016	20	29905437
Memory impairment	19.20	14.08	18	47003	37156	29868301
Occult blood	18.96	14.08	9	47012	260	29905197
Haemodynamic instability	18.85	14.08	40	46981	7975	29897482
Catheter site haemorrhage	18.80	14.08	20	47001	2152	29903305
Rectal cancer	18.76	14.08	20	47001	2156	29903301
Hallucination	18.76	14.08	30	46991	49029	29856428
Colitis ischaemic	18.66	14.08	33	46988	5753	29899704
Angioedema	18.54	14.08	16	47005	34368	29871089
Pneumonitis	18.50	14.08	10	47011	27444	29878013
Gastric ulcer	18.47	14.08	59	46962	15062	29890395
Mesenteric haemorrhage	18.18	14.08	4	47017	6	29905451
Abdominal discomfort	18.14	14.08	135	46886	48656	29856801
Arterial injury	18.14	14.08	9	47012	287	29905170
Oxygen saturation decreased	18.13	14.08	25	46996	43415	29862042
Traumatic haematoma	17.87	14.08	12	47009	683	29904774
Cardiac pacemaker insertion	17.85	14.08	21	47000	2524	29902933
Intestinal infarction	17.73	14.08	11	47010	546	29904911
Intentional product misuse	17.66	14.08	17	47004	34650	29870807
Peripheral swelling	17.64	14.08	44	46977	61030	29844427
Splenic injury	17.47	14.08	5	47016	31	29905426
Aortic aneurysm	17.45	14.08	34	46987	6379	29899078
Confusional state	17.40	14.08	132	46889	134702	29770755
Hypersensitivity	17.15	14.08	37	46984	53991	29851466
Orthopaedic procedure	17.13	14.08	4	47017	9	29905448
Blood cholesterol increased	17.10	14.08	3	47018	16967	29888490
Occult blood positive	16.99	14.08	25	46996	3735	29901722
Drug reaction with eosinophilia and systemic symptoms	16.95	14.08	12	47009	28476	29876981
Dry skin	16.94	14.08	7	47014	22447	29883010
Puncture site haemorrhage	16.91	14.08	9	47012	333	29905124
Internal haemorrhage	16.62	14.08	27	46994	4395	29901062
Prothrombin time shortened	16.53	14.08	16	47005	1539	29903918
Gait disturbance	16.49	14.08	61	46960	74716	29830741
Monoparesis	16.42	14.08	15	47006	1341	29904116
Inguinal hernia strangulated	16.38	14.08	3	47018	0	29905457
Diverticulum	16.30	14.08	34	46987	6699	29898758
Diverticulitis intestinal haemorrhagic	16.27	14.08	9	47012	360	29905097
Incarcerated inguinal hernia	16.26	14.08	6	47015	90	29905367
Blood lactate dehydrogenase increased	16.24	14.08	6	47015	20595	29884862
Small intestinal haemorrhage	16.02	14.08	18	47003	2058	29903399
Lymphocyte count decreased	15.98	14.08	5	47016	19050	29886407
Injury	15.91	14.08	72	46949	21659	29883798
Aortic dissection rupture	15.84	14.08	4	47017	14	29905443
Eye haemorrhage	15.83	14.08	24	46997	3683	29901774
Pain in extremity	15.63	14.08	105	46916	110116	29795341
Pruritus	15.59	14.08	115	46906	118089	29787368
Gastritis erosive	15.57	14.08	30	46991	5583	29899874
Therapy non-responder	15.52	14.08	14	47007	29439	29876018
Hypokalaemia	15.41	14.08	35	46986	50157	29855300
Peripheral ischaemia	15.40	14.08	29	46992	5305	29900152
Microvillous inclusion disease	15.38	14.08	5	47016	50	29905407
Hyponatraemia	15.36	14.08	54	46967	67148	29838309
Conjunctival haemorrhage	15.27	14.08	20	47001	2680	29902777
Intentional overdose	15.26	14.08	26	46995	41455	29864002
Pneumocystis jirovecii pneumonia	15.26	14.08	4	47017	17116	29888341
Influenza	15.25	14.08	28	46993	43370	29862087
Tachycardia	15.08	14.08	62	46959	73677	29831780
Encephalopathy	15.04	14.08	17	47004	32188	29873269
Thrombotic cerebral infarction	15.01	14.08	8	47013	297	29905160
Post procedural pulmonary embolism	14.87	14.08	4	47017	19	29905438
Drug ineffective	14.86	14.08	414	46607	339973	29565484
Skin laceration	14.76	14.08	45	46976	11206	29894251
Cataract	14.65	14.08	8	47013	21827	29883630
Thoracic haemorrhage	14.50	14.08	7	47014	210	29905247
Muscle strain	14.47	14.08	23	46998	3676	29901781
Serotonin syndrome	14.46	14.08	5	47016	17886	29887571
Duodenitis	14.29	14.08	24	46997	4016	29901441
Oesophageal injury	14.23	14.08	4	47017	23	29905434
Hip fracture	14.13	14.08	44	46977	11080	29894377
Mechanical ileus	14.11	14.08	7	47014	223	29905234

Pharmacologic Action:

Source	Code	Description
ATC	B01AE07	BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Direct thrombin inhibitors
MeSH PA	D000925	Anticoagulants
MeSH PA	D000991	Antithrombins
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D006401	Hematologic Agents
MeSH PA	D011480	Protease Inhibitors
MeSH PA	D015842	Serine Proteinase Inhibitors
CHEBI has role	CHEBI:50249	anticoagulante
CHEBI has role	CHEBI:50266	prodrugs
CHEBI has role	CHEBI:65232	ec 3.4.21.5 inhibitor
CHEBI has role	CHEBI:77020	nrh:quinone oxidoreductase 2 inhibitors

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Prevention of deep vein thrombosis	indication	439993001
Prevention of Thromboembolism with Chronic Atrial Fibrillation	indication
Acute hemorrhage	contraindication	8573003
Acute nephropathy	contraindication	58574008
Blood coagulation disorder	contraindication	64779008	DOID:1247
Anemia	contraindication	271737000	DOID:2355
Cerebral hemorrhage	contraindication	274100004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	5.35	Basic
pKa2	2.31	Basic
pKa3	1.61	Basic
pKa4	0.55	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Prothrombin	Enzyme	P00734	THRB_HUMAN	INHIBITOR	Ki	8.35		CHEMBL	CHEMBL
Trypsin	Enzyme	P07477 P07478 P35030	TRY1_HUMAN TRY2_HUMAN TRY3_HUMAN		Ki	7.30		CHEMBL
Plasminogen	Enzyme	P00747	PLMN_HUMAN		Ki	5.77		CHEMBL
Coagulation factor X	Enzyme	P00742	FA10_HUMAN		Ki	5.42		CHEMBL
Solute carrier family 22 member 2	Transporter	O15244	S22A2_HUMAN		IC50	5.33		CHEMBL
Multidrug and toxin extrusion protein 1	Transporter	Q96FL8	S47A1_HUMAN		IC50	5.09		CHEMBL
Ribosyldihydronicotinamide dehydrogenase [quinone]	Enzyme	P16083	NQO2_HUMAN		IC50	4.96		CHEMBL
Vitamin K-dependent protein C	Enzyme	P04070	PROC_HUMAN		Ki	4.68		CHEMBL
Multidrug and toxin extrusion protein 2	Transporter	Q86VL8	S47A2_HUMAN		IC50	4.60		CHEMBL
Serine protease hepsin	Enzyme	P05981	HEPS_HUMAN		Ki	6.08		CHEMBL
Tissue-type plasminogen activator	Enzyme	P00750	TPA_HUMAN		Ki	4.34		CHEMBL

External reference:

ID	Source
4030255	VUID
N0000181837	NUI
D07082	KEGG_DRUG
872728-81-9	SECONDARY_CAS_RN
211914-51-1	SECONDARY_CAS_RN
4030254	VANDF
4030255	VANDF
C1122231	UMLSCUI
C2348066	UMLSCUI
CHEBI:70746	CHEBI
CHEBI:70752	CHEBI
CHEMBL539697	ChEMBL_ID
CHEMBL1615369	ChEMBL_ID
CHEMBL48361	ChEMBL_ID
DB06695	DRUGBANK_ID
D000069604	MESH_DESCRIPTOR_UI
135565674	PUBCHEM_CID
6379	IUPHAR_LIGAND_ID
8028	INN_ID
8027	INN_ID
2E18WX195X	UNII
I0VM4M70GC	UNII
216210	PUBCHEM_CID
6380	IUPHAR_LIGAND_ID
DB14726	DRUGBANK_ID
1037041	RXNORM
136711	MMSL
25762	MMSL
d07137	MMSL
012668	NDDF
012669	NDDF
698871007	SNOMEDCT_US
700029008	SNOMEDCT_US
700039002	SNOMEDCT_US
714788005	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Pradaxa	HUMAN PRESCRIPTION DRUG LABEL	1	0597-0108	CAPSULE	110 mg	ORAL	NDA	32 sections
Pradaxa	HUMAN PRESCRIPTION DRUG LABEL	1	0597-0355	CAPSULE	75 mg	ORAL	NDA	32 sections
Pradaxa	HUMAN PRESCRIPTION DRUG LABEL	1	0597-0360	CAPSULE	150 mg	ORAL	NDA	32 sections
PRADAXA	HUMAN PRESCRIPTION DRUG LABEL	1	21695-899	CAPSULE	150 mg	ORAL	NDA	27 sections
Pradaxa	HUMAN PRESCRIPTION DRUG LABEL	1	50090-3617	CAPSULE	150 mg	ORAL	NDA	32 sections
Pradaxa	HUMAN PRESCRIPTION DRUG LABEL	1	50090-4480	CAPSULE	150 mg	ORAL	NDA	31 sections
Pradaxa	HUMAN PRESCRIPTION DRUG LABEL	1	63629-8242	CAPSULE	150 mg	ORAL	NDA	27 sections