cycrimine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
763 77-39-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cycrimine
  • cycrimine hydrochloride
  • pagitane
  • cycrimine HCl
  • Molecular weight: 287.45
  • Formula: C19H29NO
  • CLOGP: 4.59
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 23.47
  • ALOGS: -4.50
  • ROTB: 5

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA LILLY

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:48876 muscarinic antagonist
CHEBI has role CHEBI:66956 antidyskinesia agent

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Parkinson's disease indication 49049000 DOID:14330

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M1 GPCR ANTAGONIST WOMBAT-PK CHEMBL

External reference:

IDSource
C0056835 UMLSCUI
543567RFQQ UNII
289 INN_ID
71108007 SNOMEDCT_US
22037 RXNORM
004665 NDDF
126-02-3 SECONDARY_CAS_RN
CHEBI:59692 CHEBI
C012262 MESH_SUPPLEMENTAL_RECORD_UI
DB00942 DRUGBANK_ID
CHEMBL1200828 ChEMBL_ID
2911 PUBCHEM_CID
CHEMBL1201227 ChEMBL_ID

Pharmaceutical products:

None