cyclophosphamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
alkylating agents of the cyclophosphamide group 758 50-18-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cyclophosphamide
  • cyclophosphamid
  • cyclophosphamidum
  • cyclophosphan
  • cyclophosphane
  • cytophosphan
  • mitoxan
  • cyclophosphamide hydrate
  • endoxan
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
  • Molecular weight: 261.08
  • Formula: C7H15Cl2N2O2P
  • CLOGP: 0.80
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 41.57
  • ALOGS: -1.24
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 40 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 6.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 19.15 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 74 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.73 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.87 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 8 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 16, 1959 FDA BAXTER HLTHCARE
March 26, 2019 PMDA SHIONOGI & Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 7103.21 11.47 4498 196097 113951 63174476
Neutropenia 3383.53 11.47 3419 197176 171586 63116841
Myelosuppression 2137.69 11.47 1175 199420 22528 63265899
Disease progression 1604.49 11.47 1957 198638 120801 63167626
Bone marrow failure 1477.07 11.47 1001 199594 28289 63260138
Acute myeloid leukaemia 1353.12 11.47 779 199816 16368 63272059
Agranulocytosis 1303.22 11.47 874 199721 24260 63264167
Cytokine release syndrome 1212.04 11.47 681 199914 13633 63274794
Pancytopenia 1090.78 11.47 1435 199160 95498 63192929
Mucosal inflammation 1064.55 11.47 1003 199592 45925 63242502
White blood cell count decreased 1035.00 11.47 1694 198901 137410 63151017
Leukopenia 984.26 11.47 1217 199378 76073 63212354
Haematotoxicity 971.58 11.47 510 200085 8866 63279561
Myelodysplastic syndrome 961.81 11.47 621 199974 16133 63272294
Thrombocytopenia 942.27 11.47 1702 198893 149455 63138972
Disease recurrence 916.36 11.47 738 199857 27292 63261135
Cytomegalovirus infection 895 11.47 647 199948 20305 63268122
Neutrophil count decreased 883.99 11.47 988 199607 55418 63233009
Second primary malignancy 845.19 11.47 440 200155 7513 63280914
Product use in unapproved indication 805.51 11.47 1759 198836 177321 63111106
Cardiotoxicity 784.40 11.47 427 200168 8011 63280416
Pyrexia 749.76 11.47 3203 197392 467275 62821152
Pain 738.43 11.47 754 199841 739874 62548553
Malignant neoplasm progression 712.77 11.47 1074 199521 81047 63207380
Diffuse large B-cell lymphoma recurrent 686.08 11.47 263 200332 2057 63286370
Pneumocystis jirovecii pneumonia 667.49 11.47 498 200097 16416 63272011
Acute graft versus host disease 646.11 11.47 304 200291 4124 63284303
Ejection fraction decreased 611.82 11.47 531 200064 21801 63266626
Joint swelling 603.30 11.47 147 200448 327519 62960908
Febrile bone marrow aplasia 597.05 11.47 340 200255 6985 63281442
Abdominal discomfort 596.59 11.47 141 200454 320744 62967683
Cystitis haemorrhagic 576.88 11.47 275 200320 3848 63284579
Cytopenia 566.81 11.47 389 200206 11212 63277215
Venoocclusive liver disease 561.50 11.47 284 200311 4551 63283876
Pemphigus 557.41 11.47 4 200591 183722 63104705
Sepsis 554.40 11.47 1382 199213 151741 63136686
Progressive multifocal leukoencephalopathy 534.47 11.47 392 200203 12579 63275848
Neurotoxicity 533.39 11.47 437 200158 16553 63271874
Synovitis 525.01 11.47 14 200581 186904 63101523
Arthralgia 519.49 11.47 623 199972 569087 62719340
Neoplasm progression 513.01 11.47 604 199991 35824 63252603
Hypogammaglobulinaemia 511.44 11.47 305 200290 6850 63281577
Fall 509.10 11.47 305 200290 392029 62896398
Septic shock 507.80 11.47 821 199774 65808 63222619
Glossodynia 507.70 11.47 12 200583 178864 63109563
Graft versus host disease 498.33 11.47 294 200301 6469 63281958
Contraindicated product administered 497.27 11.47 54 200541 217594 63070833
Off label use 491.62 11.47 3723 196872 670739 62617688
Therapy partial responder 489.34 11.47 344 200251 10314 63278113
Swelling 486.74 11.47 134 200461 275244 63013183
Metastases to bone 481.64 11.47 452 200143 20567 63267860
Rheumatoid arthritis 480.63 11.47 107 200488 253712 63034715
Arthropathy 480.32 11.47 82 200513 234710 63053717
Product dose omission issue 470.25 11.47 86 200509 234227 63054200
Cardiomyopathy 469.36 11.47 412 200183 17172 63271255
Posterior reversible encephalopathy syndrome 464.18 11.47 407 200188 16938 63271489
Systemic lupus erythematosus 461.94 11.47 58 200537 208860 63079567
Hepatitis B reactivation 459.64 11.47 216 200379 2921 63285506
Premature menopause 458.02 11.47 152 200443 734 63287693
Neutropenic sepsis 446.50 11.47 389 200206 16049 63272378
Chronic graft versus host disease 437.35 11.47 208 200387 2894 63285533
Acute graft versus host disease in skin 422.13 11.47 210 200385 3242 63285185
Haemophagocytic lymphohistiocytosis 412.82 11.47 310 200285 10317 63278110
Multiple organ dysfunction syndrome 411.72 11.47 684 199911 56068 63232359
Wound 406.85 11.47 28 200567 163235 63125192
Pruritus 403.99 11.47 330 200265 361123 62927304
Therapeutic product effect decreased 402.79 11.47 64 200531 193123 63095304
Peripheral swelling 393.37 11.47 174 200421 265768 63022659
Nasopharyngitis 382.97 11.47 162 200433 254095 63034332
Neuropathy peripheral 378.08 11.47 994 199601 112673 63175754
Completed suicide 378.02 11.47 20 200575 145653 63142774
Weight increased 369.68 11.47 181 200414 260611 63027816
Anaemia 365.75 11.47 1862 198733 291568 62996859
Drug hypersensitivity 360.51 11.47 273 200322 310414 62978013
Metastases to liver 359.73 11.47 408 200187 23231 63265196
Respiratory failure 358.58 11.47 910 199685 100948 63187479
Cytomegalovirus infection reactivation 358.50 11.47 197 200398 3766 63284661
Tumour lysis syndrome 353.11 11.47 264 200331 8726 63279701
Immune effector cell-associated neurotoxicity syndrome 349.77 11.47 162 200433 2115 63286312
Platelet count decreased 348.70 11.47 978 199617 115144 63173283
Cardiac failure 333.32 11.47 815 199780 88327 63200100
Headache 329.70 11.47 972 199623 632269 62656158
Rash 325.57 11.47 816 199779 560055 62728372
Left ventricular dysfunction 316.15 11.47 279 200316 11709 63276718
Epstein-Barr virus infection 313.06 11.47 235 200360 7815 63280612
Hepatitis B 294.79 11.47 171 200424 3641 63284786
Acute lymphocytic leukaemia recurrent 289.24 11.47 142 200453 2127 63286300
Musculoskeletal stiffness 288.69 11.47 111 200484 184507 63103920
Palmar-plantar erythrodysaesthesia syndrome 287.16 11.47 359 200236 22656 63265771
Graft versus host disease in skin 286.71 11.47 153 200442 2752 63285675
Bronchopulmonary aspergillosis 283.45 11.47 228 200367 8407 63280020
Sinusitis 276.04 11.47 189 200406 226464 63061963
Injection site pain 275.03 11.47 41 200554 129759 63158668
Aplasia 272.16 11.47 169 200426 4090 63284337
Dizziness 271.18 11.47 598 199997 429327 62859100
Metastases to lung 270.85 11.47 263 200332 12487 63275940
Anxiety 268.14 11.47 179 200416 217362 63071065
Post transplant lymphoproliferative disorder 267.96 11.47 178 200417 4853 63283574
Acute promyelocytic leukaemia 266.65 11.47 103 200492 824 63287603
Pleural effusion 264.16 11.47 769 199826 92441 63195986
Hepatic enzyme increased 263.81 11.47 156 200439 202172 63086255
Ovarian failure 258.26 11.47 111 200484 1199 63287228
Contusion 257.51 11.47 77 200518 149967 63138460
Bone pain 256.81 11.47 547 200048 54094 63234333
Pain in extremity 256.67 11.47 407 200188 331079 62957348
Helicobacter infection 256.55 11.47 8 200587 92777 63195650
Psoriatic arthropathy 256.31 11.47 7 200588 91513 63196914
Thrombotic microangiopathy 255.24 11.47 234 200361 10327 63278100
Interstitial lung disease 248.59 11.47 582 200013 61326 63227101
Staphylococcal bacteraemia 245.77 11.47 175 200420 5355 63283072
Blood cholesterol increased 243.62 11.47 13 200582 94019 63194408
Duodenal ulcer perforation 243.01 11.47 7 200588 87202 63201225
Discomfort 241.87 11.47 113 200482 167261 63121166
Metastases to lymph nodes 235.63 11.47 200 200395 7958 63280469
Fatigue 233.90 11.47 1747 198848 886281 62402146
Cytomegalovirus viraemia 231.07 11.47 170 200425 5479 63282948
Pericarditis 228.57 11.47 66 200529 131513 63156914
Congestive cardiomyopathy 228.32 11.47 175 200420 6007 63282420
Venoocclusive disease 227.67 11.47 117 200478 1941 63286486
Hypersensitivity 226.86 11.47 359 200236 292326 62996101
Diffuse large B-cell lymphoma 226.23 11.47 180 200415 6532 63281895
Blood lactate dehydrogenase increased 225.95 11.47 320 200275 22796 63265631
Fibromyalgia 225.77 11.47 6 200589 80414 63208013
Neutropenic colitis 221.36 11.47 132 200463 2963 63285464
Irritable bowel syndrome 221.26 11.47 9 200586 82403 63206024
Diffuse large B-cell lymphoma refractory 212.57 11.47 95 200500 1135 63287292
Intentional overdose 210.18 11.47 5 200590 74147 63214280
Breast cancer recurrent 208.34 11.47 144 200451 4197 63284230
Blood pressure increased 206.95 11.47 128 200467 161934 63126493
Overdose 206.85 11.47 54 200541 115024 63173403
Maternal exposure before pregnancy 206.60 11.47 180 200415 7423 63281004
Infusion related reaction 204.96 11.47 286 200309 245235 63043192
Aspergillus infection 204.76 11.47 184 200411 7909 63280518
Human herpesvirus 6 infection 203.42 11.47 123 200472 2834 63285593
Malaise 202.10 11.47 658 199937 415296 62873131
BK virus infection 201.69 11.47 127 200468 3152 63285275
Graft versus host disease in gastrointestinal tract 200.53 11.47 126 200469 3115 63285312
Drug intolerance 200.50 11.47 422 200173 308239 62980188
Mobility decreased 199.28 11.47 67 200528 121092 63167335
Lymphopenia 199.11 11.47 267 200328 18060 63270367
Metastases to central nervous system 197.34 11.47 225 200370 12880 63275547
Feeling abnormal 192.55 11.47 115 200480 148277 63140150
Psoriasis 189.97 11.47 25 200570 86932 63201495
Adenovirus infection 186.95 11.47 125 200470 3446 63284981
Drug resistance 184.77 11.47 290 200305 22643 63265784
Polyneuropathy 184.27 11.47 229 200366 14360 63274067
Breast cancer metastatic 182.09 11.47 207 200388 11811 63276616
Acute lymphocytic leukaemia 181.75 11.47 108 200487 2408 63286019
Cytomegalovirus chorioretinitis 181.37 11.47 96 200499 1697 63286730
Bacteraemia 179.76 11.47 247 200348 17101 63271326
Cardiac dysfunction 179.41 11.47 104 200491 2211 63286216
Osteoarthritis 176.66 11.47 42 200553 95301 63193126
Folliculitis 175.26 11.47 12 200583 70305 63218122
Migraine 168.48 11.47 58 200537 103288 63185139
Injection site erythema 165.67 11.47 31 200564 83143 63205284
Asthma 165.28 11.47 99 200496 127462 63160965
Urticaria 165.11 11.47 168 200427 165634 63122793
Loss of personal independence in daily activities 164.94 11.47 51 200544 97239 63191188
Arthritis 164.76 11.47 80 200515 115841 63172586
Mucormycosis 163.68 11.47 106 200489 2765 63285662
Peripheral sensory neuropathy 162.60 11.47 156 200439 7295 63281132
Injury 162.57 11.47 20 200575 73227 63215200
Impaired healing 161.30 11.47 61 200534 102481 63185946
Organising pneumonia 159.48 11.47 138 200457 5638 63282789
Blister 158.26 11.47 108 200487 129706 63158721
Computerised tomogram thorax abnormal 157.70 11.47 87 200508 1676 63286751
Gait disturbance 157.22 11.47 209 200386 182969 63105458
Muscle spasms 156.88 11.47 157 200438 155993 63132434
Metastasis 155.43 11.47 130 200465 5067 63283360
Condition aggravated 155.40 11.47 698 199897 401519 62886908
Wheezing 155.22 11.47 54 200541 95541 63192886
Neoplasm recurrence 154.35 11.47 99 200496 2539 63285888
Blood follicle stimulating hormone increased 152.22 11.47 44 200551 119 63288308
Inappropriate schedule of product administration 151.98 11.47 69 200526 103896 63184531
Lymphocyte count decreased 149.23 11.47 309 200286 29948 63258479
Insomnia 148.48 11.47 284 200311 214968 63073459
Depression 145.60 11.47 248 200347 196244 63092183
Hepatic function abnormal 143.44 11.47 344 200251 36798 63251629
Abdominal pain upper 142.72 11.47 272 200323 206172 63082255
Acute respiratory distress syndrome 141.17 11.47 261 200334 23273 63265154
Viral haemorrhagic cystitis 140.28 11.47 64 200531 805 63287622
Lymphadenopathy 139.81 11.47 348 200247 38110 63250317
Confusional state 137.36 11.47 343 200252 236037 63052390
Drug abuse 136.21 11.47 31 200564 72487 63215940
JC virus infection 135.15 11.47 83 200512 1968 63286459
Hospitalisation 134.84 11.47 50 200545 85031 63203396
Somnolence 134.71 11.47 223 200372 178462 63109965
B-cell lymphoma recurrent 133.61 11.47 50 200545 363 63288064
Varicella zoster virus infection 133.30 11.47 91 200504 2598 63285829
Hypoxia 132.28 11.47 453 200142 59339 63229088
Bronchitis 130.85 11.47 121 200474 124814 63163613
Intentional product misuse 129.55 11.47 19 200576 60898 63227529
Acute graft versus host disease in intestine 128.76 11.47 76 200519 1673 63286754
Therapy responder 127.51 11.47 46 200549 297 63288130
Central nervous system lymphoma 125.84 11.47 71 200524 1431 63286996
Epstein-Barr virus associated lymphoproliferative disorder 125.71 11.47 77 200518 1817 63286610
Enterococcal infection 125.44 11.47 139 200456 7709 63280718
Injection site reaction 125.05 11.47 18 200577 58506 63229921
Stem cell transplant 123.30 11.47 75 200520 1747 63286680
Pulmonary haemorrhage 123.16 11.47 132 200463 7049 63281378
Pneumonitis 122.06 11.47 313 200282 34909 63253518
Suicide attempt 120.68 11.47 23 200572 60895 63227532
Staphylococcal sepsis 119.76 11.47 138 200457 7990 63280437
Leukoencephalopathy 116.94 11.47 103 200492 4310 63284117
Injection site swelling 116.02 11.47 9 200586 47563 63240864
Drug interaction 115.60 11.47 356 200239 228775 63059652
Adverse drug reaction 114.80 11.47 54 200541 79660 63208767
Injection site pruritus 114.50 11.47 7 200588 45109 63243318
Primary hypogonadism 114.09 11.47 36 200559 143 63288284
Klebsiella infection 113.90 11.47 138 200457 8428 63279999
Pulmonary alveolar haemorrhage 111.96 11.47 103 200492 4565 63283862
Escherichia bacteraemia 111.74 11.47 95 200500 3788 63284639
Ascites 111.45 11.47 332 200263 40396 63248031
Colony stimulating factor therapy 110.96 11.47 41 200554 286 63288141
Lymphoma 110.75 11.47 163 200432 12024 63276403
Granulocytopenia 109.36 11.47 111 200484 5561 63282866
Systemic candida 107.17 11.47 86 200509 3159 63285268
Pericardial effusion 107.16 11.47 270 200325 29788 63258639
Systemic mycosis 106.88 11.47 59 200536 1138 63287289
Chemotherapy 106.86 11.47 65 200530 1514 63286913
Secondary immunodeficiency 106.83 11.47 62 200533 1321 63287106
Leukaemia recurrent 106.06 11.47 61 200534 1277 63287150
Multiple sclerosis relapse 105.72 11.47 14 200581 48464 63239963
Pneumonia fungal 105.62 11.47 107 200488 5348 63283079
Stress 105.54 11.47 40 200555 67127 63221300
Injection site bruising 104.88 11.47 7 200588 41903 63246524
Transplant failure 104.08 11.47 64 200531 1521 63286906
Type 2 diabetes mellitus 103.81 11.47 36 200559 63832 63224595
Capillary leak syndrome 103.28 11.47 72 200523 2128 63286299
Drug ineffective for unapproved indication 102.21 11.47 287 200308 33776 63254651
Weight decreased 101.64 11.47 489 200106 276309 63012118
Incorrect dose administered 100.62 11.47 32 200563 59936 63228491
Recurrent cancer 100.30 11.47 68 200527 1919 63286508
Neutrophil count abnormal 98.41 11.47 78 200517 2814 63285613
Ovarian atrophy 98.16 11.47 28 200567 71 63288356
Clostridium difficile colitis 96.69 11.47 206 200389 20363 63268064
C-reactive protein abnormal 96.59 11.47 15 200580 46081 63242346
B-cell type acute leukaemia 96.44 11.47 33 200562 178 63288249
Refractory anaemia with an excess of blasts 95.16 11.47 40 200555 407 63288020
Pneumatosis intestinalis 95.06 11.47 71 200524 2342 63286085
Product use issue 94.75 11.47 367 200228 220153 63068274
Bacterial sepsis 94.28 11.47 87 200508 3871 63284556
Myeloid leukaemia 93.15 11.47 38 200557 356 63288071
Product quality issue 92.74 11.47 5 200590 35860 63252567
Biopsy lung abnormal 92.64 11.47 30 200565 132 63288295
Anti-Muellerian hormone level decreased 92.37 11.47 27 200568 77 63288350
Hepatic failure 92.25 11.47 285 200310 35371 63253056
Herpes simplex 92.14 11.47 122 200473 8149 63280278
Rhinovirus infection 91.67 11.47 91 200504 4438 63283989
Gastrooesophageal reflux disease 89.50 11.47 102 200493 95537 63192890
Adverse event 88.09 11.47 52 200543 67507 63220920
Acquired haemophilia 87.10 11.47 49 200546 982 63287445
Gene mutation 86.48 11.47 58 200537 1607 63286820
White blood cell count abnormal 85.35 11.47 102 200493 6140 63282287
Cytomegalovirus test positive 85.13 11.47 73 200522 2945 63285482
Aortitis 84.68 11.47 49 200546 1038 63287389
Blood pressure fluctuation 84.61 11.47 21 200574 46296 63242131
Prescribed overdose 84.60 11.47 6 200589 34147 63254280
Heart rate decreased 84.51 11.47 20 200575 45540 63242887
Subclavian vein thrombosis 84.42 11.47 60 200535 1830 63286597
Dry mouth 84.40 11.47 73 200522 77790 63210637
Blood glucose increased 84.32 11.47 84 200511 83672 63204755
Pre-existing disease 84.05 11.47 29 200566 161 63288266
Brain abscess 82.73 11.47 62 200533 2056 63286371
Pneumocystis jirovecii infection 82.66 11.47 54 200541 1430 63286997
Acute graft versus host disease in liver 82.57 11.47 41 200554 630 63287797
Balance disorder 82.34 11.47 87 200508 84335 63204092
Smooth muscle cell neoplasm 82.17 11.47 44 200551 797 63287630
Blood pressure systolic increased 81.85 11.47 24 200571 47373 63241054
Metastases to pleura 81.81 11.47 55 200540 1530 63286897
Maternal exposure during pregnancy 81.78 11.47 387 200208 219675 63068752
International normalised ratio increased 81.11 11.47 23 200572 46402 63242025
Chronic graft versus host disease in skin 80.96 11.47 42 200553 711 63287716
Joint injury 80.14 11.47 3 200592 29569 63258858
Sleep disorder 79.62 11.47 84 200511 81482 63206945
Nasal congestion 79.50 11.47 55 200540 65605 63222822
Suicidal ideation 78.66 11.47 50 200545 62371 63226056
Hypoalbuminaemia 78.57 11.47 137 200458 11668 63276759
Disseminated intravascular coagulation 78.50 11.47 181 200414 18870 63269557
Aplastic anaemia 78.45 11.47 122 200473 9447 63278980
Lower respiratory tract infection 78.34 11.47 190 200405 132117 63156310
Blood luteinising hormone increased 78.20 11.47 24 200571 85 63288342
Fungaemia 77.91 11.47 63 200532 2340 63286087
Pseudocirrhosis 77.65 11.47 40 200555 667 63287760
Medication error 77.49 11.47 34 200561 52250 63236177
Illness 77.43 11.47 29 200566 49030 63239397
Venous thrombosis 76.93 11.47 86 200509 4816 63283611
Lennox-Gastaut syndrome 76.91 11.47 30 200565 247 63288180
Myocarditis 76.91 11.47 126 200469 10199 63278228
Neutropenic infection 76.77 11.47 50 200545 1317 63287110
Nephrolithiasis 76.76 11.47 19 200576 41965 63246462
Palpitations 76.64 11.47 150 200445 112620 63175807
Enterococcal bacteraemia 76.20 11.47 51 200544 1408 63287019
Sedation 76.13 11.47 15 200580 38794 63249633
Pneumonia cytomegaloviral 75.95 11.47 60 200535 2154 63286273
Enterobacter infection 75.64 11.47 60 200535 2167 63286260
Amenorrhoea 75.22 11.47 122 200473 9792 63278635
Infection reactivation 75.15 11.47 47 200548 1152 63287275
Splenomegaly 73.63 11.47 129 200466 11028 63277399
Hyperpyrexia 73.55 11.47 73 200522 3559 63284868
Lung infiltration 72.83 11.47 149 200446 14314 63274113
Respiratory syncytial virus infection 72.82 11.47 100 200495 6918 63281509
Road traffic accident 72.19 11.47 14 200581 36618 63251809
Acute myelomonocytic leukaemia 72.18 11.47 26 200569 167 63288260
Memory impairment 71.43 11.47 138 200457 104120 63184307
Bursitis 71.24 11.47 15 200580 37026 63251401
Colitis 71.06 11.47 323 200272 48205 63240222
Myelopathy 70.99 11.47 64 200531 2762 63285665
Osteonecrosis 70.98 11.47 204 200391 24326 63264101
Musculoskeletal pain 70.58 11.47 114 200481 92163 63196264
Klebsiella bacteraemia 69.76 11.47 51 200544 1627 63286800
Pseudomonal sepsis 69.62 11.47 59 200536 2342 63286085
Gastrointestinal toxicity 69.56 11.47 103 200492 7638 63280789
Leukaemia cutis 69.41 11.47 22 200573 89 63288338
Bone marrow disorder 69.34 11.47 59 200536 2355 63286072
Joint stiffness 69.08 11.47 23 200572 41846 63246581
Hip arthroplasty 69.02 11.47 32 200563 47614 63240813
Chronic obstructive pulmonary disease 68.88 11.47 58 200537 62628 63225799
Chronic myelomonocytic leukaemia 67.73 11.47 29 200566 310 63288117
Acute leukaemia 67.44 11.47 43 200552 1091 63287336
Alopecia areata 67.32 11.47 50 200545 1635 63286792
Ventricular hypokinesia 67.00 11.47 78 200517 4566 63283861
Lupus nephritis 66.84 11.47 62 200533 2777 63285650
Dyspepsia 66.82 11.47 139 200456 102057 63186370
Urinary tract infection 66.63 11.47 526 200069 264158 63024269
Fusarium infection 66.51 11.47 35 200560 611 63287816
Embolism 66.50 11.47 102 200493 7804 63280623
Unevaluable event 66.36 11.47 40 200555 51346 63237081
Staphylococcal infection 66.02 11.47 282 200313 40974 63247453
Foot deformity 65.91 11.47 6 200589 27847 63260580
Sciatica 65.81 11.47 14 200581 34310 63254117
Serotonin syndrome 65.71 11.47 7 200588 28675 63259752
Metastases to skin 65.67 11.47 49 200546 1614 63286813
Engraftment syndrome 65.37 11.47 32 200563 476 63287951
Ear infection 64.80 11.47 20 200575 38193 63250234
Osteosarcoma 64.55 11.47 22 200573 117 63288310
Nocardiosis 64.48 11.47 52 200543 1924 63286503
Hypoglycaemia 64.26 11.47 57 200538 60008 63228419
Injection site haemorrhage 64.11 11.47 3 200592 24311 63264116
Intestinal perforation 63.53 11.47 126 200469 11837 63276590
Refractory cytopenia with multilineage dysplasia 63.19 11.47 22 200573 126 63288301
Death 63 11.47 1588 199007 372793 62915634
Peripheral motor neuropathy 62.98 11.47 48 200547 1633 63286794
Emotional distress 62.97 11.47 13 200582 32536 63255891
Amnesia 62.85 11.47 50 200545 55535 63232892
Myocardial infarction 62.71 11.47 139 200456 99754 63188673
Hypoaesthesia 62.62 11.47 296 200299 168097 63120330
Hallucination 62.37 11.47 49 200546 54768 63233659
Proteinuria 62.10 11.47 166 200429 18979 63269448
Candida infection 61.99 11.47 214 200381 28137 63260290
Alveolar soft part sarcoma 61.94 11.47 20 200575 87 63288340
Alveolitis 61.66 11.47 60 200535 2855 63285572
Strongyloidiasis 61.31 11.47 42 200553 1206 63287221
Dry eye 61.21 11.47 26 200569 40735 63247692
Vasogenic cerebral oedema 60.94 11.47 37 200558 859 63287568
Cardiomyopathy acute 60.93 11.47 25 200570 238 63288189
Hypertransaminasaemia 60.92 11.47 89 200506 6520 63281907
Gastric disorder 60.83 11.47 21 200574 37348 63251079
Myeloproliferative neoplasm 60.55 11.47 31 200564 510 63287917
B precursor type acute leukaemia 60.36 11.47 24 200571 209 63288218
Frequent bowel movements 60.19 11.47 3 200592 23019 63265408
Idiopathic pneumonia syndrome 59.65 11.47 27 200568 333 63288094
Pulmonary embolism 59.57 11.47 597 199998 116087 63172340
Drug withdrawal syndrome 58.94 11.47 8 200587 27186 63261241
Osteolysis 58.64 11.47 58 200537 2816 63285611
Invasive lobular breast carcinoma 58.42 11.47 36 200559 859 63287568
Mantle cell lymphoma recurrent 58.18 11.47 23 200572 197 63288230
Acne 57.96 11.47 4 200591 23289 63265138
Mitral valve incompetence 57.71 11.47 164 200431 19430 63268997
Acute monocytic leukaemia 57.38 11.47 20 200575 115 63288312
Flatulence 57.36 11.47 19 200576 34683 63253744
Chronic myeloid leukaemia 57.26 11.47 52 200543 2266 63286161
Prescribed underdose 57.14 11.47 12 200583 29677 63258750
Surgery 57.06 11.47 21 200574 35891 63252536
Gait inability 56.96 11.47 50 200545 52909 63235518
Computerised tomogram thorax 56.93 11.47 28 200567 421 63288006
Atelectasis 56.76 11.47 173 200422 21310 63267117
Plasma cell myeloma recurrent 56.76 11.47 60 200535 3153 63285274
Multifocal micronodular pneumocyte hyperplasia 56.75 11.47 18 200577 73 63288354
Bronchial polyp 56.75 11.47 18 200577 73 63288354
Therapy non-responder 56.39 11.47 422 200173 75479 63212948
Skin toxicity 56.35 11.47 72 200523 4642 63283785
Alpha haemolytic streptococcal infection 56.08 11.47 40 200555 1227 63287200
Hepatotoxicity 56.07 11.47 249 200346 36792 63251635
Hypertension 55.96 11.47 588 200007 278715 63009712
Macular degeneration 55.72 11.47 6 200589 24370 63264057
Acute myeloid leukaemia recurrent 55.71 11.47 44 200551 1579 63286848
Complications of bone marrow transplant 55.66 11.47 28 200567 443 63287984
Upper respiratory fungal infection 55.59 11.47 21 200574 157 63288270
Neck pain 55.52 11.47 83 200512 69235 63219192
Lower limb fracture 55.26 11.47 6 200589 24215 63264212
Encephalopathy 55.02 11.47 255 200340 38365 63250062
Cerebrovascular accident 55.01 11.47 167 200428 107857 63180570
Therapy interrupted 55.01 11.47 17 200578 32438 63255989
Premature delivery 54.79 11.47 215 200380 30066 63258361
Jugular vein thrombosis 54.68 11.47 58 200537 3060 63285367
Rash pruritic 54.62 11.47 65 200530 59734 63228693
Granulocyte count decreased 54.54 11.47 39 200556 1201 63287226
Ill-defined disorder 54.46 11.47 110 200485 81645 63206782
Epstein-Barr virus infection reactivation 54.39 11.47 33 200562 765 63287662
Fluid retention 54.38 11.47 65 200530 59621 63228806
Blood stem cell transplant failure 54.31 11.47 20 200575 138 63288289
Cytokine increased 54.14 11.47 16 200579 48 63288379
Encephalitis 53.90 11.47 99 200496 8781 63279646
Haematochezia 53.54 11.47 54 200541 53490 63234937
Acute pulmonary oedema 53.41 11.47 94 200501 8064 63280363
Invasive ductal breast carcinoma 53.30 11.47 86 200509 6872 63281555
Encephalitis viral 53.19 11.47 44 200551 1688 63286739
Alveolar proteinosis 53.06 11.47 25 200570 340 63288087
Nephropathy toxic 52.96 11.47 102 200493 9377 63279050
Anti-neutrophil cytoplasmic antibody positive vasculitis 52.76 11.47 55 200540 2844 63285583
Chronic lymphocytic leukaemia recurrent 52.50 11.47 22 200573 222 63288205
Hyperferritinaemia 52.41 11.47 21 200574 187 63288240
Metastases to chest wall 52.32 11.47 29 200566 564 63287863
Leukaemia 51.46 11.47 65 200530 4143 63284284
Meningitis cryptococcal 50.89 11.47 39 200556 1338 63287089
Angioedema 50.73 11.47 46 200549 47919 63240508
Disseminated mucormycosis 50.72 11.47 20 200575 170 63288257
Oedema peripheral 50.31 11.47 371 200224 189140 63099287
Viraemia 50.24 11.47 38 200557 1278 63287149
Device related thrombosis 49.99 11.47 43 200552 1742 63286685
Toxic cardiomyopathy 49.96 11.47 19 200576 145 63288282
Obliterative bronchiolitis 49.80 11.47 46 200549 2049 63286378
Swollen tongue 49.44 11.47 24 200571 34776 63253651
Nervousness 49.41 11.47 18 200577 30961 63257466
Radiation skin injury 49.34 11.47 33 200562 910 63287517
Femur fracture 49.20 11.47 36 200559 41720 63246707
Lactic acidosis 49.16 11.47 30 200565 38257 63250170
Cataract 48.99 11.47 65 200530 56988 63231439
Plasmacytoma 48.86 11.47 50 200545 2529 63285898
Bone marrow transplant 48.82 11.47 30 200565 712 63287715
Cytomegalovirus colitis 48.64 11.47 48 200547 2324 63286103
Left ventricular dilatation 48.35 11.47 26 200569 475 63287952
Treatment noncompliance 48.27 11.47 29 200566 37296 63251131
Device dislocation 48.24 11.47 11 200584 25694 63262733
Systemic scleroderma 48.16 11.47 33 200562 948 63287479
Red blood cell sedimentation rate increased 47.94 11.47 41 200554 43941 63244486
Hyperhidrosis 47.86 11.47 177 200418 107659 63180768
Bacterial infection 47.81 11.47 153 200442 19346 63269081
Burning sensation 47.73 11.47 61 200534 54346 63234081
Lung consolidation 47.47 11.47 62 200533 4086 63284341
5q minus syndrome 47.37 11.47 20 200575 206 63288221
Pneumomediastinum 47.30 11.47 38 200557 1398 63287029
Loss of consciousness 47.28 11.47 202 200393 117919 63170508
Grip strength decreased 47.27 11.47 7 200588 22280 63266147
Gastrointestinal necrosis 47.22 11.47 51 200544 2747 63285680
Cutaneous calcification 47.22 11.47 17 200578 109 63288318
Pseudomonas infection 46.71 11.47 107 200488 11106 63277321
Osteonecrosis of jaw 46.46 11.47 227 200368 34896 63253531
Heart rate increased 46.35 11.47 148 200447 94090 63194337
Skin laceration 46.21 11.47 8 200587 22700 63265727
B-cell lymphoma refractory 46.20 11.47 16 200579 90 63288337
Lymphoma transformation 46.17 11.47 18 200577 148 63288279
Dyspnoea 46.13 11.47 1668 198927 659645 62628782
Ileus paralytic 45.94 11.47 64 200531 4487 63283940
Microangiopathic haemolytic anaemia 45.67 11.47 27 200568 596 63287831
Foot fracture 45.35 11.47 10 200585 23904 63264523
Lupus vasculitis 45.26 11.47 26 200569 543 63287884
Sinus disorder 45.10 11.47 11 200584 24542 63263885
Hydrothorax 44.95 11.47 31 200564 900 63287527
Gastrosplenic fistula 44.90 11.47 14 200581 53 63288374
Back pain 44.41 11.47 578 200017 263567 63024860
Human bocavirus infection 44.30 11.47 23 200572 390 63288037
Product prescribing error 44.15 11.47 14 200581 26275 63262152
Plasma cell leukaemia 43.96 11.47 33 200562 1097 63287330
Lymphadenitis 43.93 11.47 53 200542 3222 63285205
Pneumonia 43.90 11.47 1812 198783 454955 62833472
Parainfluenzae virus infection 43.88 11.47 45 200550 2282 63286145
Cervix disorder 43.70 11.47 26 200569 581 63287846
Oxygen saturation decreased 43.65 11.47 139 200456 88446 63199981
Seasonal allergy 43.47 11.47 7 200588 20943 63267484
Metastases to the mediastinum 43.43 11.47 24 200571 464 63287963
Refractory cytopenia with unilineage dysplasia 43.31 11.47 25 200570 527 63287900
Primary amyloidosis 43.27 11.47 13 200582 42 63288385
Cryptococcosis 43.27 11.47 33 200562 1124 63287303
Madarosis 43.20 11.47 51 200544 3030 63285397
Cystitis viral 43.17 11.47 17 200578 144 63288283
Human polyomavirus infection 43.10 11.47 21 200574 309 63288118
Procedural pain 43.02 11.47 8 200587 21561 63266866
Encephalitis cytomegalovirus 42.94 11.47 25 200570 536 63287891
Influenza 42.86 11.47 187 200408 108535 63179892
Multiple sclerosis 42.71 11.47 12 200583 24360 63264067
Klebsiella sepsis 42.69 11.47 36 200559 1419 63287008
Ototoxicity 42.67 11.47 35 200560 1327 63287100
Incorrect route of product administration 42.04 11.47 17 200578 27435 63260992
Acute hepatitis B 41.99 11.47 21 200574 328 63288099
Exostosis 41.86 11.47 4 200591 17858 63270569
Lip swelling 41.79 11.47 23 200572 31040 63257387
Eye swelling 41.50 11.47 12 200583 23906 63264521
Lumbosacral radiculoplexus neuropathy 41.03 11.47 11 200584 20 63288407
Hepatitis E 40.88 11.47 35 200560 1409 63287018
Nightmare 40.77 11.47 6 200589 19188 63269239
Disability 40.72 11.47 5 200590 18342 63270085
Device related infection 40.64 11.47 164 200431 23228 63265199
Hepatomegaly 40.51 11.47 105 200490 11784 63276643
Musculoskeletal disorder 40.45 11.47 8 200587 20636 63267791
Aggression 40.38 11.47 12 200583 23486 63264941
Streptococcal bacteraemia 40.28 11.47 38 200557 1739 63286688
Metastases to peritoneum 40.25 11.47 52 200543 3390 63285037
Pneumonia bacterial 40.18 11.47 91 200504 9374 63279053
Nephrotic syndrome 40.12 11.47 67 200528 5509 63282918
Vision blurred 40.06 11.47 152 200443 91772 63196655
Tremor 40.01 11.47 249 200346 131990 63156437
Escherichia sepsis 39.88 11.47 63 200532 4944 63283483
B-cell aplasia 39.81 11.47 14 200581 83 63288344
Injection site rash 39.68 11.47 6 200589 18803 63269624
Extravasation 39.62 11.47 43 200552 2329 63286098
Kidney infection 39.53 11.47 12 200583 23164 63265263
Joint range of motion decreased 39.46 11.47 27 200568 32401 63256026
Graft versus host disease in liver 39.29 11.47 25 200570 632 63287795
Intervertebral disc protrusion 39.15 11.47 13 200582 23696 63264731
Metastases to bone marrow 39.14 11.47 22 200573 440 63287987
Panic attack 39.12 11.47 11 200584 22320 63266107
Clostridium bacteraemia 39.12 11.47 17 200578 189 63288238
Portal hypertension 38.99 11.47 54 200541 3765 63284662
Disease susceptibility 38.96 11.47 17 200578 191 63288236
Acquired gene mutation 38.89 11.47 29 200566 954 63287473
Haemoglobin decreased 38.88 11.47 661 199934 144824 63143603
Cardiac failure acute 38.71 11.47 90 200505 9433 63278994
Herpes zoster meningoencephalitis 38.67 11.47 19 200576 285 63288142
Limb injury 38.66 11.47 16 200579 25461 63262966
Human herpesvirus 8 infection 38.52 11.47 18 200577 240 63288187
Engraft failure 38.17 11.47 20 200575 346 63288081
Accidental overdose 38.11 11.47 13 200582 23296 63265131
Coronary artery disease 38.03 11.47 28 200567 32349 63256078
Quadriplegia 37.98 11.47 37 200558 1763 63286664
Minimal residual disease 37.89 11.47 15 200580 129 63288298
Agitation 37.62 11.47 83 200512 59674 63228753
Toxoplasmosis 37.29 11.47 34 200561 1489 63286938
Nodular regenerative hyperplasia 37.28 11.47 22 200573 484 63287943
Plasma cell myeloma 37.22 11.47 217 200378 35688 63252739
Cardiogenic shock 37.17 11.47 133 200462 17799 63270628
Localised infection 36.97 11.47 25 200570 30185 63258242
Feeling hot 36.84 11.47 64 200531 50290 63238137
Autoimmune haemolytic anaemia 36.80 11.47 58 200537 4543 63283884
Carbohydrate antigen 15-3 increased 36.78 11.47 33 200562 1415 63287012
Cytogenetic abnormality 36.76 11.47 22 200573 497 63287930
Pneumonia pneumococcal 36.73 11.47 40 200555 2175 63286252
Injection site warmth 36.70 11.47 3 200592 15192 63273235
Febrile infection 36.65 11.47 34 200561 1523 63286904
Drug ineffective 36.51 11.47 2826 197769 1041939 62246488
Alternaria infection 35.90 11.47 17 200578 234 63288193
Blast cells present 35.71 11.47 21 200574 459 63287968
Plasma cell myeloma refractory 35.69 11.47 19 200576 340 63288087
Osteomyelitis bacterial 35.66 11.47 16 200579 193 63288234
Unintentional medical device removal 35.64 11.47 67 200528 6048 63282379
Tendonitis 35.62 11.47 9 200586 19606 63268821
Blood culture positive 35.56 11.47 58 200537 4677 63283750
Joint dislocation 35.37 11.47 8 200587 18792 63269635
Hip fracture 35.26 11.47 25 200570 29449 63258978
Therapeutic response unexpected 35.26 11.47 8 200587 18751 63269676
Angiocentric lymphoma 35.24 11.47 23 200572 608 63287819
Periarticular thenar erythema with onycholysis 35.20 11.47 11 200584 42 63288385
Vasculitis 35.17 11.47 132 200463 18077 63270350
Humoral immune defect 35.02 11.47 17 200578 248 63288179
Delayed engraftment 35.00 11.47 14 200581 124 63288303
Injection site mass 34.97 11.47 8 200587 18648 63269779
Ankle fracture 34.81 11.47 7 200588 17848 63270579
Human herpesvirus 7 infection 34.81 11.47 14 200581 126 63288301
Withdrawal syndrome 34.75 11.47 10 200585 19987 63268440
Metastases to meninges 34.73 11.47 42 200553 2560 63285867
Graft versus host disease in lung 34.58 11.47 19 200576 363 63288064
Throat irritation 34.29 11.47 41 200554 37606 63250821
Traumatic lung injury 34.16 11.47 33 200562 1556 63286871
Clonal evolution 34.14 11.47 12 200583 71 63288356
Guillain-Barre syndrome 33.84 11.47 51 200544 3842 63284585
Lymphadenopathy mediastinal 33.74 11.47 43 200552 2765 63285662
Citrobacter bacteraemia 33.70 11.47 9 200586 16 63288411
Perineal infection 33.70 11.47 14 200581 138 63288289
Dysplasia 33.63 11.47 26 200569 904 63287523
Abortion spontaneous 33.61 11.47 61 200534 47134 63241293
Enterococcal sepsis 33.45 11.47 31 200564 1387 63287040
Gastrointestinal fungal infection 33.32 11.47 18 200577 332 63288095
Crying 33.31 11.47 16 200579 23327 63265100
Bradycardia 33.28 11.47 119 200476 73108 63215319
Ocular hyperaemia 33.27 11.47 19 200576 25125 63263302
Pneumothorax 33.19 11.47 120 200475 16141 63272286
Hair colour changes 33.11 11.47 45 200550 3082 63285345
Primary cardiac lymphoma 33.01 11.47 9 200586 18 63288409
Lymphangiosis carcinomatosa 32.95 11.47 31 200564 1414 63287013
Paraparesis 32.84 11.47 38 200557 2210 63286217
B-lymphocyte count abnormal 32.83 11.47 11 200584 55 63288372
Visual impairment 32.82 11.47 146 200449 84300 63204127
Lymphocytosis 32.66 11.47 42 200553 2725 63285702
Perineal necrosis 32.62 11.47 13 200582 114 63288313
Respiratory distress 32.51 11.47 201 200394 33750 63254677
Generalised oedema 32.51 11.47 117 200478 15701 63272726
Therapy cessation 32.46 11.47 29 200566 30428 63257999
Alopecia 32.45 11.47 815 199780 336721 62951706
Miller Fisher syndrome 32.44 11.47 12 200583 84 63288343
Candida sepsis 32.22 11.47 30 200565 1350 63287077
Blood pressure diastolic abnormal 32.19 11.47 4 200591 14538 63273889
Gas gangrene 32.13 11.47 13 200582 119 63288308
Systolic dysfunction 32.12 11.47 32 200563 1567 63286860
Haematuria 32.05 11.47 179 200416 28978 63259449
Klebsiella test positive 32.04 11.47 28 200567 1159 63287268
Drug effective for unapproved indication 32.03 11.47 46 200549 3318 63285109
Gastroenteritis norovirus 31.97 11.47 36 200559 2032 63286395
Epstein-Barr viraemia 31.73 11.47 26 200569 984 63287443
Oesophageal candidiasis 31.71 11.47 61 200534 5602 63282825
Sinus congestion 31.61 11.47 9 200586 18114 63270313
Disseminated toxoplasmosis 31.57 11.47 13 200582 125 63288302
Labelled drug-drug interaction medication error 31.40 11.47 3 200592 13396 63275031
Pulmonary veno-occlusive disease 31.39 11.47 27 200568 1094 63287333
Troponin I increased 31.31 11.47 37 200558 2201 63286226
Babesiosis 31.20 11.47 15 200580 214 63288213
Adenoviral hepatitis 31.04 11.47 18 200577 383 63288044
Respiratory tract congestion 30.84 11.47 9 200586 17823 63270604
IIIrd nerve paralysis 30.81 11.47 22 200573 676 63287751
Hormone receptor positive breast cancer 30.80 11.47 20 200575 524 63287903
Laryngitis fungal 30.78 11.47 13 200582 134 63288293
Hyperviscosity syndrome 30.76 11.47 14 200581 175 63288252
Hepatocellular injury 30.70 11.47 169 200426 27212 63261215
Administration site extravasation 30.65 11.47 25 200570 940 63287487
Nail pigmentation 30.55 11.47 14 200581 178 63288249
Triple negative breast cancer 30.53 11.47 13 200582 137 63288290
Adenovirus reactivation 30.44 11.47 13 200582 138 63288289
Mood altered 30.43 11.47 5 200590 14738 63273689
Rash macular 30.42 11.47 18 200577 23346 63265081
Sopor 30.41 11.47 16 200579 22148 63266279
Blood iron decreased 30.36 11.47 5 200590 14716 63273711
Combined immunodeficiency 30.33 11.47 12 200583 103 63288324
Respiratory arrest 30.33 11.47 35 200560 32610 63255817
Blood pressure diastolic decreased 30.27 11.47 17 200578 22689 63265738
Paraneoplastic pemphigus 30.23 11.47 11 200584 73 63288354
Orthostatic hypotension 30.23 11.47 42 200553 36118 63252309
Vocal cord paralysis 30.15 11.47 36 200559 2165 63286262
Acute lymphocytic leukaemia refractory 30.11 11.47 11 200584 74 63288353
Blood immunoglobulin G decreased 30.11 11.47 38 200557 2420 63286007
Bone lesion 30.10 11.47 61 200534 5820 63282607
Eye irritation 29.94 11.47 16 200579 21955 63266472
Lupus-like syndrome 29.81 11.47 6 200589 15289 63273138
Erythropoiesis abnormal 29.72 11.47 16 200579 293 63288134
Disseminated cryptococcosis 29.68 11.47 18 200577 417 63288010
Pulmonary toxicity 29.68 11.47 81 200514 9374 63279053
Product complaint 29.67 11.47 3 200592 12806 63275621
Retinal haemorrhage 29.66 11.47 55 200540 4914 63283513
Ligament sprain 29.64 11.47 3 200592 12797 63275630
Hyperkalaemia 29.63 11.47 81 200514 54122 63234305
Diffuse alveolar damage 29.60 11.47 24 200571 895 63287532
Sleep apnoea syndrome 29.56 11.47 29 200566 29104 63259323
Muscle spasticity 29.51 11.47 16 200579 21778 63266649
Necrosis 29.38 11.47 58 200537 5429 63282998
Epstein Barr virus positive mucocutaneous ulcer 29.23 11.47 18 200577 429 63287998
T-cell lymphoma 29.14 11.47 21 200574 655 63287772
Fear 29.08 11.47 7 200588 15759 63272668
Enteritis 29.08 11.47 74 200521 8212 63280215
Feeling jittery 28.91 11.47 4 200591 13399 63275028
Chest pain 28.87 11.47 494 200101 215465 63072962
Metastases to spine 28.86 11.47 43 200552 3206 63285221
Glaucoma 28.48 11.47 12 200583 18893 63269534
Adult T-cell lymphoma/leukaemia 28.44 11.47 14 200581 211 63288216
Transaminases increased 28.36 11.47 183 200412 31184 63257243
Gallbladder disorder 28.32 11.47 12 200583 18830 63269597
Polyomavirus-associated nephropathy 28.28 11.47 32 200563 1816 63286611
Haematocrit decreased 28.24 11.47 217 200378 39123 63249304
Cytomegalovirus urinary tract infection 28.20 11.47 10 200585 61 63288366
Primary mediastinal large B-cell lymphoma recurrent 28.20 11.47 10 200585 61 63288366
Myelitis 28.04 11.47 28 200567 1375 63287052
Cranial nerve disorder 28.03 11.47 19 200576 536 63287891
Restlessness 27.99 11.47 31 200564 29422 63259005
Tuberculosis of central nervous system 27.94 11.47 16 200579 332 63288095
Hyperbilirubinaemia 27.94 11.47 89 200506 11225 63277202
Cardiac cirrhosis 27.89 11.47 12 200583 130 63288297
Chronic kidney disease 27.80 11.47 64 200531 45334 63243093
Live birth 27.80 11.47 24 200571 25606 63262821
Malignant transformation 27.80 11.47 17 200578 400 63288027
Trichosporon infection 27.75 11.47 15 200580 277 63288150
Skin discolouration 27.74 11.47 48 200547 37780 63250647
Facet joint syndrome 27.71 11.47 3 200592 12135 63276292
Parvovirus infection 27.61 11.47 15 200580 280 63288147
Intracardiac thrombus 27.54 11.47 36 200559 2374 63286053
Necrotising gastritis 27.53 11.47 10 200585 66 63288361
Arteritis 27.52 11.47 20 200575 632 63287795
Eczema 27.51 11.47 37 200558 32254 63256173
Limb discomfort 27.45 11.47 32 200563 29684 63258743
Large intestinal ulcer perforation 27.41 11.47 10 200585 67 63288360
Irritability 27.32 11.47 36 200559 31658 63256769
Hair follicle tumour benign 27.28 11.47 17 200578 414 63288013
Hypoproteinaemia 27.22 11.47 33 200562 2016 63286411
Blood calcium decreased 27.22 11.47 26 200569 26425 63262002
Human herpesvirus 6 encephalitis 27.20 11.47 14 200581 233 63288194
Dermatomyositis 27.20 11.47 39 200556 2809 63285618
Haemolytic anaemia 27.18 11.47 82 200513 10043 63278384
Leukocytosis 27.04 11.47 157 200438 25778 63262649
Central nervous system infection 27.04 11.47 21 200574 735 63287692
Acute biphenotypic leukaemia 27.03 11.47 10 200585 70 63288357
Pneumonia influenzal 27.02 11.47 30 200565 1667 63286760
Nasal abscess 27.01 11.47 13 200582 186 63288241
Therapeutic response shortened 26.98 11.47 3 200592 11885 63276542
Symptom masked 26.97 11.47 21 200574 738 63287689
B-cell lymphoma 26.90 11.47 42 200553 3263 63285164
Acute megakaryocytic leukaemia 26.86 11.47 9 200586 45 63288382
Creatinine renal clearance decreased 26.83 11.47 9 200586 16299 63272128
Spinal stenosis 26.81 11.47 7 200588 14918 63273509
Pleuroparenchymal fibroelastosis 26.79 11.47 11 200584 105 63288322
Pharyngeal inflammation 26.72 11.47 20 200575 662 63287765
Subdural hygroma 26.68 11.47 14 200581 243 63288184
Hair texture abnormal 26.63 11.47 48 200547 4195 63284232
Aspergilloma 26.62 11.47 14 200581 244 63288183
Cerebral venous sinus thrombosis 26.59 11.47 32 200563 1940 63286487
Nasal septum disorder 26.58 11.47 12 200583 147 63288280
Poor venous access 26.43 11.47 7 200588 14778 63273649
Hypersomnia 26.34 11.47 12 200583 18043 63270384
Lung diffusion test decreased 26.30 11.47 20 200575 678 63287749
Superior vena cava syndrome 26.28 11.47 20 200575 679 63287748
Cerebral toxoplasmosis 26.26 11.47 23 200572 955 63287472
Acute interstitial pneumonitis 26.15 11.47 20 200575 684 63287743
Clostridium difficile infection 26.09 11.47 173 200422 29749 63258678
Restless legs syndrome 25.99 11.47 13 200582 18518 63269909
Underdose 25.98 11.47 29 200566 27427 63261000
Hydrocephalus 25.98 11.47 54 200541 5246 63283181
Dyskinesia 25.93 11.47 38 200557 31964 63256463
Leukaemic lymphoma 25.89 11.47 10 200585 80 63288347
Enterocolitis infectious 25.87 11.47 29 200566 1629 63286798
Hepatic lesion 25.84 11.47 51 200544 4774 63283653
Carpal tunnel syndrome 25.78 11.47 17 200578 20800 63267627
Shock 25.76 11.47 144 200451 23319 63265108
Radiation necrosis 25.73 11.47 16 200579 388 63288039
Abdominal pain 25.71 11.47 718 199877 292738 62995689
Metabolic acidosis 25.66 11.47 66 200529 45003 63243424
BK polyomavirus test positive 25.64 11.47 9 200586 53 63288374
Left ventricular failure 25.63 11.47 56 200539 5631 63282796
Tumour necrosis 25.56 11.47 21 200574 798 63287629
Polyomavirus viraemia 25.41 11.47 20 200575 714 63287713
Listeria sepsis 25.39 11.47 20 200575 715 63287712
Recall phenomenon 25.33 11.47 19 200576 631 63287796
Rhabdomyolysis 25.30 11.47 64 200531 43887 63244540
Premature labour 25.28 11.47 92 200503 12412 63276015
Mesenteric abscess 25.26 11.47 10 200585 86 63288341
T-cell type acute leukaemia 25.23 11.47 9 200586 56 63288371
Focal nodular hyperplasia 25.21 11.47 18 200577 553 63287874
Depressed mood 25.15 11.47 56 200539 40135 63248292
Escherichia infection 25.08 11.47 93 200502 12661 63275766
Pregnancy 25.01 11.47 49 200546 36787 63251640
Inappropriate antidiuretic hormone secretion 24.97 11.47 106 200489 15356 63273071
Transient ischaemic attack 24.96 11.47 51 200544 37702 63250725
Device issue 24.92 11.47 23 200572 23758 63264669
Cystitis bacterial 24.91 11.47 13 200582 223 63288204
Pneumonitis chemical 24.91 11.47 13 200582 223 63288204
Drug reaction with eosinophilia and systemic symptoms 24.75 11.47 43 200552 33793 63254634
Rhabdomyosarcoma recurrent 24.74 11.47 8 200587 35 63288392
Deep vein thrombosis 24.70 11.47 387 200208 83413 63205014
PIK3CA-activated mutation 24.69 11.47 23 200572 1036 63287391
Abdominal compartment syndrome 24.60 11.47 18 200577 575 63287852
Cyst 24.60 11.47 7 200588 14092 63274335
Natural killer-cell leukaemia 24.58 11.47 10 200585 93 63288334
Soft tissue infection 24.54 11.47 32 200563 2105 63286322
Cholelithiasis 24.49 11.47 65 200530 43860 63244567
Bone marrow infiltration 24.46 11.47 19 200576 665 63287762
Campylobacter infection 24.37 11.47 23 200572 1053 63287374
Bone marrow transplant rejection 24.33 11.47 9 200586 63 63288364
Product administration error 24.26 11.47 21 200574 22376 63266051
Brain oedema 24.25 11.47 99 200496 14096 63274331
Cerebral fungal infection 24.21 11.47 10 200585 97 63288330
Thyroid dermatopathy 24.20 11.47 7 200588 19 63288408
COVID-19 pneumonia 24.19 11.47 99 200496 14110 63274317
Steroid diabetes 24.13 11.47 25 200570 1283 63287144
Stomatitis 24.01 11.47 591 200004 138134 63150293
Growth hormone deficiency 24.00 11.47 11 200584 140 63288287
Malignant pleural effusion 23.88 11.47 35 200560 2571 63285856
Pelvic kidney 23.80 11.47 5 200590 0 63288427
Head injury 23.73 11.47 31 200564 27365 63261062
Blood pressure decreased 23.73 11.47 115 200480 64907 63223520
Hilar lymphadenopathy 23.71 11.47 24 200571 1198 63287229
Ear pain 23.70 11.47 49 200546 36069 63252358
Device breakage 23.63 11.47 4 200591 11538 63276889
Vertigo 23.59 11.47 103 200492 59784 63228643
Soft tissue neoplasm 23.52 11.47 9 200586 70 63288357
Muscle rigidity 23.51 11.47 4 200591 11496 63276931
Cholecystectomy 23.48 11.47 3 200592 10674 63277753
Drug tolerance decreased 23.41 11.47 13 200582 17460 63270967
Ovarian disorder 23.37 11.47 19 200576 711 63287716
Pulmonary mucormycosis 23.29 11.47 14 200581 319 63288108
Treatment failure 23.26 11.47 466 200129 198577 63089850
Atypical haemolytic uraemic syndrome 23.26 11.47 19 200576 716 63287711
Adenoviral haemorrhagic cystitis 23.19 11.47 11 200584 152 63288275
Eye infection 23.19 11.47 5 200590 12140 63276287
Respiratory tract infection fungal 23.10 11.47 16 200579 468 63287959
Faeces discoloured 23.08 11.47 15 200580 18494 63269933
Night sweats 23.07 11.47 78 200517 48736 63239691
Scleroderma renal crisis 23.02 11.47 14 200581 326 63288101
Antithrombin III 22.94 11.47 11 200584 156 63288271
Retinal toxicity 22.86 11.47 24 200571 1251 63287176
Onycholysis 22.81 11.47 27 200568 1609 63286818
Blood fibrinogen decreased 22.78 11.47 20 200575 833 63287594
Swelling face 22.74 11.47 113 200482 63362 63225065
Hypofibrinogenaemia 22.74 11.47 23 200572 1147 63287280
Cytology abnormal 22.71 11.47 6 200589 10 63288417
Morganella infection 22.62 11.47 18 200577 653 63287774
Infection 22.60 11.47 912 199683 228261 63060166
Middle insomnia 22.57 11.47 6 200589 12637 63275790
Chronic graft versus host disease in liver 22.48 11.47 13 200582 275 63288152
Gastroenteritis viral 22.46 11.47 25 200570 23675 63264752
Mantle cell lymphoma 22.45 11.47 16 200579 490 63287937
Sneezing 22.39 11.47 15 200580 18203 63270224
Cytomegalovirus enteritis 22.36 11.47 13 200582 278 63288149
Aplasia pure red cell 22.32 11.47 46 200549 4441 63283986
Mucocutaneous ulceration 22.27 11.47 11 200584 167 63288260
Metastatic lymphoma 22.27 11.47 11 200584 167 63288260
Haematocolpos 22.26 11.47 8 200587 51 63288376
Influenza like illness 22.24 11.47 122 200473 66702 63221725
Laryngitis 22.19 11.47 13 200582 16954 63271473
B-lymphocyte count decreased 22.18 11.47 22 200573 1072 63287355
Diabetes mellitus inadequate control 22.15 11.47 10 200585 15116 63273311
Colitis ulcerative 22.12 11.47 30 200565 26061 63262366
Groin pain 22.12 11.47 3 200592 10200 63278227
Hepatosplenic T-cell lymphoma 22.11 11.47 17 200578 586 63287841
Necrotising colitis 22.11 11.47 17 200578 586 63287841
Salivary gland cancer 22.10 11.47 11 200584 170 63288257
Dystonia 22.09 11.47 8 200587 13811 63274616
Body temperature decreased 22.07 11.47 19 200576 20300 63268127
Hypertriglyceridaemia 22.07 11.47 56 200539 6203 63282224
Cystoid macular oedema 21.97 11.47 26 200569 1549 63286878
Fungal infection 21.96 11.47 195 200400 36679 63251748
Leukoerythroblastosis 21.95 11.47 12 200583 227 63288200
Dysphonia 21.88 11.47 77 200518 47537 63240890
Poisoning 21.78 11.47 8 200587 13692 63274735
Metastases to diaphragm 21.76 11.47 7 200588 30 63288397
Pneumonia pseudomonal 21.76 11.47 33 200562 2500 63285927
Product storage error 21.73 11.47 10 200585 14946 63273481
Device pacing issue 21.73 11.47 9 200586 88 63288339
Cerebellar haemangioma 21.73 11.47 9 200586 88 63288339
HER2 positive breast cancer 21.72 11.47 14 200581 362 63288065
Dry skin 21.71 11.47 99 200496 56788 63231639
Haemoglobin abnormal 21.69 11.47 49 200546 5039 63283388
Paraneoplastic syndrome 21.62 11.47 17 200578 606 63287821
Peripheral venous disease 21.49 11.47 11 200584 15466 63272961
Heart rate abnormal 21.49 11.47 48 200547 4899 63283528
Tissue infiltration 21.48 11.47 17 200578 612 63287815
Rectal haemorrhage 21.40 11.47 81 200514 48949 63239478
Eye pain 21.32 11.47 47 200548 33807 63254620
Pseudomonal bacteraemia 21.27 11.47 26 200569 1602 63286825
Cryptosporidiosis infection 21.25 11.47 13 200582 306 63288121
Glioma 21.21 11.47 13 200582 307 63288120
Postictal state 21.19 11.47 21 200574 1022 63287405
Choking 21.19 11.47 3 200592 9876 63278551
Fungal sepsis 21.17 11.47 23 200572 1247 63287180
Necrotising fasciitis 21.16 11.47 36 200559 3005 63285422
Bronchiolitis 21.11 11.47 34 200561 2713 63285714
Blood glucose decreased 21.09 11.47 21 200574 20931 63267496
Thrombotic thrombocytopenic purpura 21.09 11.47 41 200554 3795 63284632
Blood creatine phosphokinase increased 21.07 11.47 40 200555 30390 63258037
Geotrichum infection 21.06 11.47 15 200580 459 63287968
Pleural disorder 21.05 11.47 17 200578 630 63287797
Listeriosis 21.03 11.47 25 200570 1496 63286931
Blood pressure systolic abnormal 20.98 11.47 8 200587 13378 63275049
Mucosal infection 20.96 11.47 11 200584 191 63288236
Scedosporium infection 20.93 11.47 16 200579 547 63287880
Drug dependence 20.91 11.47 28 200567 24455 63263972
Radiation myelopathy 20.89 11.47 7 200588 35 63288392
Infusion site swelling 20.88 11.47 3 200592 9767 63278660
Pelvic fracture 20.88 11.47 8 200587 13340 63275087
Cytokine abnormal 20.88 11.47 5 200590 4 63288423
High-grade B-cell lymphoma 20.88 11.47 5 200590 4 63288423
Germ cell cancer 20.82 11.47 8 200587 63 63288364
Angioimmunoblastic T-cell lymphoma 20.79 11.47 9 200586 99 63288328
Opportunistic infection 20.79 11.47 28 200567 1901 63286526
Hypercholesterolaemia 20.78 11.47 22 200573 21312 63267115
Sinus polyp 20.78 11.47 14 200581 391 63288036
Chromosomal deletion 20.71 11.47 9 200586 100 63288327
Impaired work ability 20.67 11.47 15 200580 17460 63270967
Upper respiratory tract infection 20.63 11.47 163 200432 81884 63206543
Cholangiocarcinoma 20.57 11.47 22 200573 1172 63287255
Meningoencephalitis viral 20.56 11.47 13 200582 325 63288102
Affect lability 20.47 11.47 5 200590 11146 63277281
Hypogonadism 20.40 11.47 9 200586 104 63288323
Breast cancer stage III 20.40 11.47 4 200591 10382 63278045
Medulloblastoma recurrent 20.39 11.47 8 200587 67 63288360
Ventricular dysfunction 20.37 11.47 34 200561 2794 63285633
Needle issue 20.37 11.47 4 200591 10372 63278055
Impaired quality of life 20.36 11.47 9 200586 13774 63274653
Hypokalaemia 20.35 11.47 450 200145 103354 63185073
Device electrical impedance issue 20.35 11.47 5 200590 5 63288422
Hepatic infarction 20.31 11.47 17 200578 663 63287764
Mediastinum neoplasm 20.19 11.47 8 200587 69 63288358
Glycosylated haemoglobin increased 20.12 11.47 7 200588 12391 63276036
Mucoepidermoid carcinoma 20.12 11.47 7 200588 40 63288387
Rash erythematous 20.04 11.47 68 200527 42442 63245985
Myasthenia gravis crisis 20.02 11.47 15 200580 497 63287930
Immune thrombocytopenia 19.95 11.47 76 200519 10480 63277947
Hyperuricaemia 19.94 11.47 49 200546 5321 63283106
Marrow hyperplasia 19.93 11.47 17 200578 681 63287746
Lymphoproliferative disorder 19.91 11.47 36 200559 3154 63285273
Pneumococcal sepsis 19.88 11.47 17 200578 683 63287744
T-cell lymphoma recurrent 19.88 11.47 5 200590 6 63288421
Epstein-Barr virus associated lymphoma 19.87 11.47 15 200580 503 63287924
TP53 gene mutation 19.84 11.47 7 200588 42 63288385
Paranasal sinus mucosal hypertrophy 19.83 11.47 6 200589 20 63288407
Primary immunodeficiency syndrome 19.70 11.47 7 200588 43 63288384
Secretion discharge 19.69 11.47 7 200588 12224 63276203
Incorrect product administration duration 19.65 11.47 6 200589 11540 63276887
Peripheral sensorimotor neuropathy 19.63 11.47 24 200571 1479 63286948
Cerebellar stroke 19.63 11.47 12 200583 282 63288145
Primary mediastinal large B-cell lymphoma 19.61 11.47 6 200589 21 63288406
Hepatosplenomegaly 19.60 11.47 32 200563 2582 63285845
Pneumonia staphylococcal 19.58 11.47 34 200561 2886 63285541
Enteral nutrition 19.56 11.47 7 200588 44 63288383
Cancer in remission 19.56 11.47 7 200588 44 63288383
Chylothorax 19.56 11.47 12 200583 284 63288143
Syphilis 19.50 11.47 10 200585 165 63288262
Basal ganglion degeneration 19.50 11.47 14 200581 434 63287993
Clostridium colitis 19.45 11.47 27 200568 1887 63286540
Cardiac amyloidosis 19.45 11.47 18 200577 804 63287623
Disseminated strongyloidiasis 19.39 11.47 6 200589 22 63288405
Human herpesvirus 6 infection reactivation 19.36 11.47 13 200582 361 63288066
Pyomyositis 19.33 11.47 13 200582 362 63288065
Upper-airway cough syndrome 19.32 11.47 6 200589 11412 63277015
Walking aid user 19.30 11.47 5 200590 10712 63277715
Thyroid disorder 19.30 11.47 12 200583 15150 63273277
Urinary tract infection bacterial 19.30 11.47 47 200548 5075 63283352
Pseudomembranous colitis 19.27 11.47 35 200560 3077 63285350
Basal cell carcinoma 19.20 11.47 37 200558 27954 63260473
Mucosal toxicity 19.20 11.47 13 200582 366 63288061
Foetal growth restriction 19.19 11.47 60 200535 7493 63280934
Nervous system disorder 19.18 11.47 113 200482 18653 63269774
Bone marrow necrosis 19.15 11.47 8 200587 80 63288347
Metastases to breast 19.12 11.47 12 200583 296 63288131
Thinking abnormal 19.10 11.47 5 200590 10638 63277789
Superinfection bacterial 19.05 11.47 16 200579 627 63287800
Lymph node fibrosis 19.05 11.47 5 200590 8 63288419
Breast angiosarcoma 19.04 11.47 4 200591 0 63288427
Paroxysmal atrioventricular block 19.04 11.47 4 200591 0 63288427
Fungal oesophagitis 18.99 11.47 17 200578 727 63287700
Flushing 18.96 11.47 149 200446 74938 63213489
Metastases to thorax 18.93 11.47 11 200584 235 63288192
Poor quality sleep 18.92 11.47 21 200574 19914 63268513
Breast neoplasm 18.92 11.47 23 200572 1409 63287018
Malnutrition 18.91 11.47 97 200498 15201 63273226
Pseudomonas test positive 18.91 11.47 17 200578 731 63287696
Forced vital capacity decreased 18.80 11.47 20 200575 1059 63287368
Erythropenia 18.78 11.47 10 200585 179 63288248
Pulmonary oedema 18.75 11.47 260 200335 54613 63233814
Carotid intima-media thickness increased 18.73 11.47 8 200587 85 63288342
Tooth disorder 18.65 11.47 38 200557 28119 63260308
Oral disorder 18.63 11.47 66 200529 8788 63279639
Anger 18.61 11.47 8 200587 12448 63275979
Ocular vasculitis 18.57 11.47 7 200588 52 63288375
Parkinsonism 18.55 11.47 5 200590 10434 63277993
Platelet count abnormal 18.55 11.47 36 200559 3328 63285099
Synovial cyst 18.54 11.47 5 200590 10428 63277999
Tooth fracture 18.51 11.47 6 200589 11104 63277323
Hypoperfusion 18.48 11.47 23 200572 1444 63286983
Myocardial fibrosis 18.45 11.47 17 200578 755 63287672
Precursor B-lymphoblastic lymphoma 18.42 11.47 6 200589 27 63288400
Hepatitis C RNA increased 18.38 11.47 9 200586 134 63288293
Haemolysis 18.35 11.47 55 200540 6713 63281714
Chronic lymphocytic leukaemia transformation 18.23 11.47 7 200588 55 63288372
Meningitis 18.22 11.47 57 200538 7120 63281307
Herpes simplex viraemia 18.16 11.47 12 200583 324 63288103
Splenic infarction 18.15 11.47 25 200570 1734 63286693
Rib fracture 18.15 11.47 27 200568 22570 63265857
Appendiceal abscess 18.09 11.47 11 200584 256 63288171
Vena cava thrombosis 18.09 11.47 28 200567 2159 63286268
Primary adrenal insufficiency 18.08 11.47 9 200586 139 63288288
Central nervous system enteroviral infection 18.07 11.47 6 200589 29 63288398
Rhinorrhoea 18.05 11.47 127 200468 65450 63222977
Coagulopathy 18.05 11.47 119 200476 20425 63268002
Wrong technique in product usage process 18.02 11.47 119 200476 62221 63226206
Bone density decreased 18.00 11.47 12 200583 14600 63273827
Peripheral T-cell lymphoma unspecified 17.97 11.47 10 200585 196 63288231
Haemorrhage intracranial 17.94 11.47 87 200508 13332 63275095
Mycobacterial infection 17.89 11.47 25 200570 1758 63286669
Hypermetabolism 17.84 11.47 10 200585 199 63288228
Skin cancer 17.80 11.47 7 200588 11488 63276939
Endocarditis 17.79 11.47 49 200546 5701 63282726
Morphoea 17.75 11.47 12 200583 337 63288090
Fusobacterium infection 17.75 11.47 6 200589 31 63288396
Granulicatella infection 17.72 11.47 8 200587 98 63288329
Mediastinitis 17.70 11.47 10 200585 202 63288225
Eosinophilic cystitis 17.70 11.47 7 200588 60 63288367
Renal failure 17.68 11.47 492 200103 117160 63171267
Optic atrophy 17.66 11.47 21 200574 1257 63287170
Hyperproteinaemia 17.65 11.47 8 200587 99 63288328
Neurological symptom 17.61 11.47 49 200546 5734 63282693
Anaesthesia 17.59 11.47 13 200582 422 63288005
Opsoclonus myoclonus 17.58 11.47 9 200586 148 63288279
Premature baby 17.55 11.47 119 200476 20616 63267811
Infusion site streaking 17.52 11.47 14 200581 511 63287916
Burkitt's lymphoma 17.44 11.47 5 200590 13 63288414
Joint neoplasm 17.41 11.47 7 200588 63 63288364
Therapeutic product effect incomplete 17.37 11.47 284 200311 124772 63163655
Obstructive airways disorder 17.34 11.47 24 200571 20675 63267752
Pericarditis constrictive 17.32 11.47 12 200583 351 63288076
Haemodynamic instability 17.23 11.47 66 200529 9124 63279303
Sweat gland tumour 17.23 11.47 8 200587 105 63288322
Pulmonary infarction 17.15 11.47 31 200564 2716 63285711
Hepatic necrosis 17.14 11.47 48 200547 5639 63282788
Cardiac tamponade 17.13 11.47 43 200552 4732 63283695
Acinetobacter infection 17.10 11.47 23 200572 1560 63286867
Metastases to pancreas 17.05 11.47 11 200584 285 63288142
Escherichia urinary tract infection 17.05 11.47 79 200516 11883 63276544
Abdominal distension 17.04 11.47 183 200412 86432 63201995
Endocarditis bacterial 17.04 11.47 15 200580 627 63287800
Jaw operation 17.02 11.47 17 200578 835 63287592
Lymphocytic leukaemia 17.01 11.47 9 200586 159 63288268
Fungal skin infection 16.98 11.47 42 200553 4580 63283847
Blood lactate dehydrogenase abnormal 16.97 11.47 12 200583 363 63288064
CD4/CD8 ratio decreased 16.92 11.47 5 200590 15 63288412
Iron deficiency anaemia 16.89 11.47 23 200572 19946 63268481
Metastases to stomach 16.87 11.47 10 200585 222 63288205
Gastric stenosis 16.85 11.47 7 200588 69 63288358
Stenotrophomonas infection 16.83 11.47 26 200569 2001 63286426
Abnormal behaviour 16.82 11.47 26 200569 21400 63267027
Haematopoietic stem cell mobilisation 16.81 11.47 4 200591 3 63288424
Rubulavirus test positive 16.81 11.47 4 200591 3 63288424
Adenocarcinoma 16.79 11.47 32 200563 2918 63285509
Acute generalised exanthematous pustulosis 16.79 11.47 7 200588 11092 63277335
Norovirus test positive 16.79 11.47 10 200585 224 63288203
Skin mass 16.72 11.47 49 200546 5906 63282521
Human herpes virus 8 test positive 16.68 11.47 5 200590 16 63288411
Thirst 16.68 11.47 12 200583 14029 63274398
Spinal cord compression 16.64 11.47 39 200556 4109 63284318
Monoparesis 16.60 11.47 23 200572 1604 63286823
Reversible cerebral vasoconstriction syndrome 16.60 11.47 30 200565 2628 63285799
Chronic myeloid leukaemia recurrent 16.59 11.47 10 200585 229 63288198
Coma 16.58 11.47 127 200468 64237 63224190
Hallucination, visual 16.55 11.47 22 200573 19276 63269151
Mood swings 16.48 11.47 20 200575 18228 63270199
Paraplegia 16.48 11.47 30 200565 2642 63285785
Back injury 16.48 11.47 5 200590 9655 63278772
Bladder disorder 16.45 11.47 4 200591 8942 63279485
Eye disorder 16.44 11.47 29 200566 22656 63265771
Fungal endocarditis 16.44 11.47 10 200585 233 63288194
Delirium 16.42 11.47 93 200502 50448 63237979
Pain in jaw 16.42 11.47 76 200519 43420 63245007
Transient hypogammaglobulinaemia of infancy 16.34 11.47 6 200589 41 63288386
Mucosal erosion 16.33 11.47 22 200573 1494 63286933
Osteoporosis 16.29 11.47 110 200485 57228 63231199
Septic embolus 16.29 11.47 17 200578 880 63287547
Neonatal lupus erythematosus 16.28 11.47 4 200591 4 63288423
Cytomegalovirus enterocolitis 16.28 11.47 15 200580 666 63287761
Fasciitis 16.26 11.47 14 200581 568 63287859
Lipidosis 16.22 11.47 6 200589 42 63288385
Disseminated tuberculosis 16.20 11.47 31 200564 2836 63285591
Lymphangitis 16.13 11.47 17 200578 890 63287537
Tinnitus 16.12 11.47 58 200537 35570 63252857
Conjunctival scar 16.10 11.47 6 200589 43 63288384
Jejunal stenosis 16.10 11.47 6 200589 43 63288384
VIth nerve paresis 16.09 11.47 7 200588 78 63288349
Tracheo-oesophageal fistula 16.05 11.47 14 200581 578 63287849
Acute hepatic failure 16.00 11.47 106 200489 18221 63270206
Diabetic ketoacidosis 15.99 11.47 25 200570 20480 63267947
Diverticulum 15.95 11.47 9 200586 11982 63276445
Microscopic polyangiitis 15.92 11.47 9 200586 182 63288245
Ileus 15.91 11.47 90 200505 14635 63273792
Breast cancer stage II 15.88 11.47 4 200591 8732 63279695
Skin haemorrhage 15.87 11.47 6 200589 10088 63278339
Refractory cancer 15.86 11.47 7 200588 81 63288346
Erysipelas 15.85 11.47 58 200537 7847 63280580
Cytotoxic oedema 15.84 11.47 9 200586 184 63288243
Infusion site eschar 15.82 11.47 5 200590 20 63288407
Pulse waveform abnormal 15.78 11.47 7 200588 82 63288345
Ankle brachial index decreased 15.78 11.47 7 200588 82 63288345
Epidermal necrosis 15.76 11.47 18 200577 1032 63287395
Pharyngitis streptococcal 15.72 11.47 7 200588 10665 63277762
Cerebral aspergillosis 15.70 11.47 12 200583 410 63288017
Lower respiratory tract infection fungal 15.69 11.47 11 200584 328 63288099
Chronic lymphocytic leukaemia 15.68 11.47 29 200566 2585 63285842
Listeria encephalitis 15.67 11.47 10 200585 254 63288173
Congenital syphilitic osteochondritis 15.63 11.47 5 200590 21 63288406
Herpes zoster cutaneous disseminated 15.62 11.47 9 200586 189 63288238
Metapneumovirus infection 15.62 11.47 18 200577 1042 63287385
Respiratory tract infection 15.60 11.47 200 200395 41283 63247144
Interleukin level increased 15.58 11.47 12 200583 415 63288012
Water intoxication 15.58 11.47 12 200583 415 63288012
Blood pressure abnormal 15.57 11.47 15 200580 15183 63273244
Toxic neuropathy 15.55 11.47 12 200583 416 63288011
Retching 15.54 11.47 14 200581 14631 63273796
Cytomegalovirus oesophagitis 15.54 11.47 10 200585 258 63288169
Peritonitis viral 15.53 11.47 6 200589 48 63288379
Chromosome analysis abnormal 15.50 11.47 8 200587 134 63288293
Paraesthesia oral 15.47 11.47 23 200572 19233 63269194
Vascular compression 15.46 11.47 9 200586 193 63288234
Full blood count abnormal 15.45 11.47 50 200545 31667 63256760
Metaplasia 15.45 11.47 13 200582 511 63287916
Central nervous system leukaemia 15.44 11.47 8 200587 135 63288292
Rotator cuff syndrome 15.44 11.47 12 200583 13490 63274937
Median nerve injury 15.44 11.47 5 200590 22 63288405
Non-Hodgkin's lymphoma recurrent 15.40 11.47 4 200591 6 63288421
Bone erosion 15.40 11.47 20 200575 17697 63270730
Hypotelorism of orbit 15.40 11.47 4 200591 6 63288421
Hemiparesis 15.38 11.47 126 200469 23156 63265271
Abdominal neoplasm 15.38 11.47 11 200584 339 63288088
Light chain analysis increased 15.37 11.47 20 200575 1313 63287114
Post-acute COVID-19 syndrome 15.35 11.47 12 200583 424 63288003
Pneumonia adenoviral 15.34 11.47 8 200587 137 63288290
Metastases to uterus 15.28 11.47 7 200588 89 63288338
Vaginal discharge 15.26 11.47 5 200590 9193 63279234
Leukonychia 15.26 11.47 5 200590 23 63288404
Chronic sinusitis 15.22 11.47 11 200584 12832 63275595
Anti-platelet antibody positive 15.22 11.47 6 200589 51 63288376
Feeling cold 15.18 11.47 33 200562 23855 63264572
Hallucination, auditory 15.18 11.47 11 200584 12813 63275614
Emotional disorder 15.16 11.47 12 200583 13367 63275060
Febrile convulsion 15.16 11.47 12 200583 432 63287995
Akathisia 15.13 11.47 5 200590 9141 63279286
Laryngopharyngitis 15.12 11.47 6 200589 52 63288375
Blast cell count increased 15.11 11.47 12 200583 434 63287993
Merycism 15.10 11.47 10 200585 271 63288156
Oesophagitis 15.10 11.47 90 200505 14918 63273509
Joint effusion 15.09 11.47 19 200576 17041 63271386
Superior mesenteric artery syndrome 15.07 11.47 7 200588 92 63288335
Haptoglobin decreased 15.07 11.47 15 200580 734 63287693
Duodenal stenosis 15.06 11.47 13 200582 529 63287898
Evans syndrome 15.05 11.47 9 200586 203 63288224
Red blood cell schistocytes present 15.04 11.47 10 200585 273 63288154
Reproductive toxicity 15.02 11.47 4 200591 7 63288420
Meningitis bacterial 14.97 11.47 20 200575 1347 63287080
Staphylococcus test positive 14.94 11.47 36 200559 3860 63284567
Rosai-Dorfman syndrome 14.92 11.47 5 200590 25 63288402
Pleurodesis 14.92 11.47 5 200590 25 63288402
Tricuspid valve incompetence 14.91 11.47 88 200507 14533 63273894
Small intestinal perforation 14.84 11.47 21 200574 1494 63286933
Streptococcal sepsis 14.83 11.47 24 200571 1922 63286505
Product dose omission in error 14.81 11.47 3 200592 7609 63280818
Pleural neoplasm 14.80 11.47 11 200584 360 63288067
Leukaemic infiltration 14.76 11.47 5 200590 26 63288401
Viral sepsis 14.76 11.47 5 200590 26 63288401
Corynebacterium infection 14.72 11.47 13 200582 546 63287881
Mycobacterium abscessus infection 14.67 11.47 14 200581 650 63287777
Alopecia totalis 14.64 11.47 11 200584 366 63288061
Electrocardiogram QT prolonged 14.62 11.47 119 200476 59411 63229016
Oophoritis 14.61 11.47 7 200588 99 63288328
Artificial menopause 14.61 11.47 5 200590 27 63288400
Microsporidia infection 14.60 11.47 10 200585 287 63288140
Blood potassium increased 14.58 11.47 22 200573 18287 63270140
Deafness 14.57 11.47 102 200493 17855 63270572
Movement disorder 14.54 11.47 29 200566 21632 63266795
Food allergy 14.54 11.47 9 200586 11392 63277035
Appendicitis 14.54 11.47 58 200537 8171 63280256
Troponin increased 14.54 11.47 67 200528 10054 63278373
Skin fissures 14.51 11.47 9 200586 11379 63277048
Diffuse large B-cell lymphoma stage IV 14.48 11.47 10 200585 291 63288136
Gait apraxia 14.46 11.47 5 200590 28 63288399
Spinal cord disorder 14.43 11.47 19 200576 1262 63287165
Metastases to eye 14.41 11.47 8 200587 156 63288271
Metastases to retroperitoneum 14.41 11.47 8 200587 156 63288271
Areflexia 14.39 11.47 31 200564 3087 63285340
Skin hypopigmentation 14.38 11.47 15 200580 776 63287651
Enterocolitis 14.38 11.47 56 200539 7802 63280625
Trichodysplasia spinulosa 14.36 11.47 13 200582 564 63287863
Monocyte count decreased 14.34 11.47 25 200570 2128 63286299
Hepatic calcification 14.31 11.47 5 200590 29 63288398
T-cell prolymphocytic leukaemia 14.28 11.47 3 200592 0 63288427
Autologous haematopoietic stem cell transplant 14.28 11.47 3 200592 0 63288427
Lymphoid tissue hypoplasia 14.28 11.47 3 200592 0 63288427
Ovarian Sertoli-Leydig cell tumour 14.28 11.47 3 200592 0 63288427
Tachycardia 14.25 11.47 481 200114 117675 63170752
Gastritis fungal 14.25 11.47 7 200588 105 63288322
Brachydactyly 14.25 11.47 7 200588 105 63288322
Body height decreased 14.24 11.47 7 200588 10071 63278356
Gastrointestinal mucormycosis 14.23 11.47 9 200586 225 63288202
Follicular lymphoma 14.20 11.47 9 200586 226 63288201
Atrial rupture 14.19 11.47 6 200589 62 63288365
Inflammation 14.18 11.47 179 200416 82094 63206333
Arachnoid cyst 14.16 11.47 9 200586 227 63288200
Anal infection 14.11 11.47 6 200589 63 63288364
Cachexia 14.10 11.47 45 200550 5681 63282746
Pneumonia respiratory syncytial viral 14.10 11.47 17 200578 1033 63287394
Actinomycotic sepsis 14.07 11.47 7 200588 108 63288319
Haemolytic uraemic syndrome 14.06 11.47 27 200568 2476 63285951
Mantle cell lymphoma refractory 14.06 11.47 4 200591 10 63288417
Head discomfort 14.02 11.47 13 200582 13402 63275025
Radiation injury 14.02 11.47 12 200583 483 63287944
Central nervous system viral infection 13.96 11.47 7 200588 110 63288317
Urinary tract infection viral 13.94 11.47 6 200589 65 63288362
Increased tendency to bruise 13.92 11.47 8 200587 10544 63277883
Oedema due to cardiac disease 13.90 11.47 5 200590 32 63288395
Stenotrophomonas sepsis 13.90 11.47 5 200590 32 63288395
Enterocolitis haemorrhagic 13.89 11.47 20 200575 1446 63286981
Oligohydramnios 13.87 11.47 48 200547 6318 63282109
Left ventricular enlargement 13.86 11.47 6 200589 66 63288361
Deformity 13.86 11.47 10 200585 11674 63276753
Ovarian cyst 13.86 11.47 18 200577 15927 63272500
Pneumonia aspiration 13.85 11.47 59 200536 34481 63253946
Hypoglossal nerve paresis 13.85 11.47 7 200588 112 63288315
Monoplegia 13.84 11.47 31 200564 3170 63285257
Tooth infection 13.83 11.47 22 200573 17898 63270529
Dislocation of vertebra 13.80 11.47 5 200590 8630 63279797
Endocardial fibrosis 13.79 11.47 4 200591 11 63288416
Oedema 13.79 11.47 221 200374 97401 63191026
Cardio-respiratory arrest 13.77 11.47 122 200473 59837 63228590
Foot operation 13.76 11.47 3 200592 7228 63281199
Growth retardation 13.75 11.47 19 200576 1322 63287105
Glomerulonephritis membranous 13.74 11.47 13 200582 597 63287830
Mycobacterium chelonae infection 13.67 11.47 12 200583 500 63287927
Aphasia 13.66 11.47 162 200433 32838 63255589
Sputum discoloured 13.65 11.47 19 200576 16328 63272099
Dysstasia 13.65 11.47 29 200566 21137 63267290
Dementia 13.64 11.47 24 200571 18770 63269657
Scoliosis 13.61 11.47 4 200591 7884 63280543
Intentional product use issue 13.59 11.47 304 200291 127588 63160839
Hiatus hernia 13.58 11.47 30 200565 21564 63266863
Cardiac ventricular thrombosis 13.58 11.47 13 200582 606 63287821
Cushingoid 13.57 11.47 58 200537 8427 63280000
Jejunal ulcer perforation 13.52 11.47 5 200590 35 63288392
Microangiopathy 13.50 11.47 18 200577 1210 63287217
Cytokine storm 13.49 11.47 10 200585 326 63288101
Immune-mediated hypophysitis 13.48 11.47 6 200589 71 63288356
Epstein-Barr virus test positive 13.47 11.47 13 200582 612 63287815
Injection site phlebitis 13.42 11.47 7 200588 120 63288307
Chromaturia 13.40 11.47 20 200575 16697 63271730
Acquired macroglossia 13.40 11.47 8 200587 180 63288247
Splenic marginal zone lymphoma 13.40 11.47 5 200590 36 63288391
Xerophthalmia 13.39 11.47 12 200583 514 63287913
Delusion 13.34 11.47 11 200584 12006 63276421
Acral peeling skin syndrome 13.30 11.47 4 200591 13 63288414
Cytomegalovirus gastritis 13.28 11.47 8 200587 183 63288244
Toxicity to various agents 13.26 11.47 642 199953 246608 63041819
Axillary vein thrombosis 13.25 11.47 10 200585 335 63288092
Enterobacter bacteraemia 13.21 11.47 11 200584 426 63288001
Eastern Cooperative Oncology Group performance status worsened 13.21 11.47 18 200577 1236 63287191
Telangiectasia 13.19 11.47 16 200579 978 63287449
Vitamin D decreased 13.18 11.47 8 200587 10234 63278193
Paratracheal lymphadenopathy 13.16 11.47 5 200590 38 63288389
Eating disorder 13.16 11.47 25 200570 18991 63269436
Leukaemic infiltration extramedullary 13.11 11.47 6 200589 76 63288351
Frustration tolerance decreased 13.09 11.47 3 200592 6985 63281442
Cardiac murmur 13.09 11.47 16 200579 14536 63273891
Pathological fracture 13.08 11.47 59 200536 8775 63279652
Upper limb fracture 13.08 11.47 25 200570 18943 63269484
Neurological decompensation 13.07 11.47 27 200568 2611 63285816
Nail disorder 13.06 11.47 78 200517 12937 63275490
Uterine enlargement 13.05 11.47 18 200577 1250 63287177
Hepatic infection fungal 13.05 11.47 5 200590 39 63288388
Cardiac failure chronic 13.03 11.47 37 200558 4381 63284046
Lymphomatoid papulosis 13.01 11.47 7 200588 128 63288299
N-terminal prohormone brain natriuretic peptide increased 13.00 11.47 24 200571 2137 63286290
Chest discomfort 12.97 11.47 257 200338 109712 63178715
Muscular weakness 12.95 11.47 291 200304 122062 63166365
Menopause 12.94 11.47 28 200567 2797 63285630
Angina pectoris 12.93 11.47 50 200545 30028 63258399
Neuroblastoma recurrent 12.91 11.47 6 200589 79 63288348
Pulmonary necrosis 12.87 11.47 7 200588 131 63288296
Bone sarcoma 12.86 11.47 4 200591 15 63288412
Blood phosphorus decreased 12.85 11.47 37 200558 4416 63284011
Candida test positive 12.84 11.47 15 200580 881 63287546
Chronic hepatitis 12.84 11.47 15 200580 881 63287546
Lethargy 12.84 11.47 114 200481 55893 63232534
Acute hepatitis C 12.84 11.47 6 200589 80 63288347
Breast cancer stage I 12.82 11.47 3 200592 6886 63281541
Large intestine perforation 12.82 11.47 57 200538 8425 63280002
Psychomotor hyperactivity 12.81 11.47 9 200586 10654 63277773
Pneumonia parainfluenzae viral 12.77 11.47 6 200589 81 63288346
Procalcitonin increased 12.76 11.47 17 200578 1142 63287285
Hydronephrosis 12.76 11.47 67 200528 10595 63277832
Obesity 12.74 11.47 50 200545 29902 63258525
Liver scan abnormal 12.73 11.47 5 200590 42 63288385
Lymph node pain 12.73 11.47 19 200576 1419 63287008
Autoimmune neutropenia 12.72 11.47 8 200587 198 63288229
Pulmonary vein stenosis 12.71 11.47 6 200589 82 63288345
Malignant ascites 12.71 11.47 15 200580 891 63287536
Metastatic neoplasm 12.70 11.47 36 200559 4259 63284168
Rhinitis allergic 12.70 11.47 11 200584 11716 63276711
Metastases to abdominal cavity 12.68 11.47 11 200584 451 63287976
Lymphocytic infiltration 12.66 11.47 15 200580 895 63287532
Clonal haematopoiesis 12.66 11.47 4 200591 16 63288411
Hepatic candidiasis 12.66 11.47 4 200591 16 63288411
Beta 2 microglobulin decreased 12.66 11.47 4 200591 16 63288411
Herpes oesophagitis 12.65 11.47 8 200587 200 63288227
Vaginal infection 12.63 11.47 4 200591 7514 63280913
Tenosynovitis 12.59 11.47 15 200580 13780 63274647
Liver function test increased 12.58 11.47 57 200538 32754 63255673
Arteritis infective 12.53 11.47 5 200590 44 63288383
Tuberous sclerosis complex 12.52 11.47 6 200589 85 63288342
Myocardial oedema 12.51 11.47 8 200587 204 63288223
Actinomycosis 12.49 11.47 16 200579 1034 63287393
Cutaneous mucormycosis 12.46 11.47 4 200591 17 63288410
Tumour marker increased 12.44 11.47 39 200556 4876 63283551
Stress cardiomyopathy 12.44 11.47 61 200534 9389 63279038
Sarcoidosis 12.43 11.47 50 200545 7072 63281355
Respiratory depression 12.42 11.47 15 200580 13700 63274727
Skin abrasion 12.41 11.47 7 200588 9322 63279105
Immunosuppression 12.40 11.47 58 200537 8756 63279671
Hodgkin's disease 12.37 11.47 14 200581 795 63287632
Diarrhoea haemorrhagic 12.36 11.47 59 200536 8983 63279444
Chronic lymphocytic leukaemia refractory 12.34 11.47 5 200590 46 63288381
Campylobacter gastroenteritis 12.33 11.47 11 200584 468 63287959
Oral fungal infection 12.33 11.47 29 200566 3062 63285365
Venous haemorrhage 12.29 11.47 9 200586 288 63288139
Respiratory tract infection bacterial 12.29 11.47 9 200586 288 63288139
Marginal zone lymphoma recurrent 12.28 11.47 4 200591 18 63288409
Tumour haemorrhage 12.28 11.47 20 200575 1611 63286816
Papillary thyroid cancer 12.27 11.47 24 200571 2232 63286195
Orbital infection 12.24 11.47 5 200590 47 63288380
Lipomatosis 12.24 11.47 5 200590 47 63288380
Leukostasis syndrome 12.24 11.47 5 200590 47 63288380
Li-Fraumeni syndrome 12.21 11.47 3 200592 3 63288424
Breast prosthesis removal 12.21 11.47 3 200592 3 63288424
Allogenic bone marrow transplantation therapy 12.21 11.47 3 200592 3 63288424
Follicle centre lymphoma, follicular grade I, II, III stage IV 12.21 11.47 3 200592 3 63288424
Acute cutaneous lupus erythematosus 12.21 11.47 9 200586 291 63288136
Herpes virus infection 12.20 11.47 42 200553 5514 63282913
Retinopathy 12.16 11.47 29 200566 3090 63285337
Intraductal proliferative breast lesion 12.15 11.47 28 200567 2917 63285510
Culture stool positive 12.15 11.47 9 200586 293 63288134
Carotidynia 12.11 11.47 7 200588 148 63288279
Neuromuscular toxicity 12.11 11.47 7 200588 148 63288279
Central nervous system vasculitis 12.09 11.47 15 200580 939 63287488
Bipolar disorder 12.07 11.47 5 200590 7955 63280472
Scintillating scotoma 12.07 11.47 7 200588 149 63288278
Ischaemic enteritis 12.06 11.47 5 200590 49 63288378
Meningoencephalitis herpetic 12.04 11.47 17 200578 1207 63287220
Atrioventricular block first degree 11.99 11.47 4 200591 7269 63281158
Liver function test abnormal 11.98 11.47 96 200499 48085 63240342
Atrial thrombosis 11.97 11.47 21 200574 1797 63286630
Poikiloderma 11.95 11.47 8 200587 221 63288206
SARS-CoV-2 test negative 11.95 11.47 11 200584 488 63287939
Malignant neoplasm of orbit 11.94 11.47 4 200591 20 63288407
Lymphatic obstruction 11.94 11.47 4 200591 20 63288407
West Nile viral infection 11.93 11.47 10 200585 391 63288036
Subacute combined cord degeneration 11.92 11.47 8 200587 222 63288205
Intracranial pressure increased 11.90 11.47 40 200555 5187 63283240
Retinitis viral 11.88 11.47 5 200590 51 63288376
Pulmonary vascular disorder 11.88 11.47 10 200585 393 63288034
Pleocytosis 11.87 11.47 14 200581 831 63287596
Cardiac disorder 11.84 11.47 103 200492 50713 63237714
Hypersensitivity pneumonitis 11.84 11.47 26 200569 2624 63285803
Hemianopia 11.83 11.47 16 200579 1091 63287336
Enterovirus test positive 11.82 11.47 7 200588 155 63288272
Toothache 11.81 11.47 27 200568 19172 63269255
Hypophosphataemia 11.80 11.47 69 200526 11357 63277070
T-lymphocyte count decreased 11.79 11.47 9 200586 307 63288120
Increased appetite 11.74 11.47 8 200587 9622 63278805
Transplant dysfunction 11.73 11.47 38 200557 4834 63283593
Extramedullary haemopoiesis 11.72 11.47 5 200590 53 63288374
Arthritis infective 11.71 11.47 3 200592 6475 63281952
Fracture 11.68 11.47 28 200567 19556 63268871
Metastases to spleen 11.66 11.47 7 200588 159 63288268
Magnetic resonance imaging head abnormal 11.66 11.47 22 200573 1991 63286436
Otitis media 11.65 11.47 38 200557 4853 63283574
Gastric neoplasm 11.64 11.47 9 200586 313 63288114
Blood loss anaemia 11.63 11.47 7 200588 8994 63279433
Precursor T-lymphoblastic lymphoma/leukaemia 11.62 11.47 4 200591 22 63288405
Gestational diabetes 11.61 11.47 6 200589 8390 63280037
Pericardial effusion malignant 11.60 11.47 6 200589 101 63288326
Dandy-Walker syndrome 11.60 11.47 6 200589 101 63288326
Kaposi's sarcoma 11.59 11.47 7 200588 161 63288266
Bladder perforation 11.59 11.47 7 200588 161 63288266
Pulmonary function test decreased 11.59 11.47 33 200562 3914 63284513
Lung abscess 11.56 11.47 21 200574 1847 63286580
Pseudomyopia 11.55 11.47 5 200590 55 63288372
Hypocalcaemia 11.55 11.47 152 200443 31561 63256866
Metastases to heart 11.54 11.47 6 200589 102 63288325
Quadriparesis 11.54 11.47 22 200573 2007 63286420
Cellulitis staphylococcal 11.53 11.47 13 200582 735 63287692
Restrictive cardiomyopathy 11.52 11.47 9 200586 318 63288109
Pharyngeal swelling 11.51 11.47 3 200592 6401 63282026
Low cardiac output syndrome 11.50 11.47 10 200585 411 63288016
Maternal exposure timing unspecified 11.50 11.47 4 200591 7083 63281344
Status epilepticus 11.48 11.47 85 200510 15148 63273279
Corynebacterium sepsis 11.48 11.47 4 200591 23 63288404

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 4447.80 12.77 4287 163668 132562 34656414
Cytokine release syndrome 1599.88 12.77 1123 166832 21754 34767222
Neutropenia 1571.11 12.77 2746 165209 154032 34634944
Myelosuppression 1216.57 12.77 889 167066 18376 34770600
Product use in unapproved indication 1192.18 12.77 2071 165884 115428 34673548
Disease progression 1184.99 12.77 1972 165983 106105 34682871
Mucosal inflammation 895.65 12.77 1014 166941 37608 34751368
Off label use 895.62 12.77 4176 163779 415348 34373628
Hypogammaglobulinaemia 871.13 12.77 513 167442 7227 34781749
Acute graft versus host disease 800.84 12.77 457 167498 6046 34782930
Myelodysplastic syndrome 795.52 12.77 692 167263 18516 34770460
Bone marrow failure 793.07 12.77 834 167121 28419 34760557
Cytomegalovirus infection 764.16 12.77 776 167179 25359 34763617
Hepatitis B 746.29 12.77 424 167531 5559 34783417
Cystitis haemorrhagic 728.74 12.77 410 167545 5269 34783707
Haematotoxicity 715.62 12.77 462 167493 7732 34781244
Progressive multifocal leukoencephalopathy 709.45 12.77 491 167464 9273 34779703
Diffuse large B-cell lymphoma recurrent 700.95 12.77 332 167623 2896 34786080
Cytopenia 640.04 12.77 513 167442 12210 34776766
Pancytopenia 637.90 12.77 1410 166545 93747 34695229
Acute myeloid leukaemia 586.70 12.77 571 167384 17699 34771277
Chronic graft versus host disease 548.33 12.77 311 167644 4062 34784914
Graft versus host disease 537.67 12.77 429 167526 10140 34778836
Second primary malignancy 525.12 12.77 376 167579 7510 34781466
Pyrexia 516.83 12.77 3039 164916 329974 34459002
Hepatitis B reactivation 513.04 12.77 286 167669 3605 34785371
Venoocclusive liver disease 492.21 12.77 363 167592 7603 34781373
Therapy partial responder 477.83 12.77 385 167570 9231 34779745
Acute graft versus host disease in skin 468.34 12.77 299 167656 4902 34784074
Thrombocytopenia 462.86 12.77 1724 166231 154523 34634453
Drug abuse 453.67 12.77 4 167951 99092 34689884
Fall 445.70 12.77 209 167746 202676 34586300
Neutrophil count decreased 442.23 12.77 842 167113 50262 34738714
Completed suicide 440.12 12.77 6 167949 98162 34690814
Tumour lysis syndrome 436.76 12.77 472 167483 16587 34772389
Neurotoxicity 420.82 12.77 475 167480 17535 34771441
Pneumocystis jirovecii pneumonia 399.11 12.77 483 167472 19227 34769749
Cytomegalovirus infection reactivation 396.92 12.77 268 167687 4850 34784126
Product dose omission issue 391.87 12.77 55 167900 119656 34669320
Posterior reversible encephalopathy syndrome 382.83 12.77 344 167611 9610 34779366
Venoocclusive disease 367.83 12.77 207 167748 2660 34786316
Neutropenic sepsis 364.89 12.77 388 167567 13379 34775597
Arthralgia 358.40 12.77 185 167770 169856 34619120
Immune effector cell-associated neurotoxicity syndrome 358.21 12.77 223 167732 3490 34785486
Febrile bone marrow aplasia 350.37 12.77 301 167654 7908 34781068
Sepsis 346.35 12.77 1650 166305 164911 34624065
BK virus infection 344.45 12.77 257 167698 5481 34783495
Dizziness 341.86 12.77 328 167627 218193 34570783
Drug interaction 338.76 12.77 352 167603 225594 34563382
Haemophagocytic lymphohistiocytosis 325.17 12.77 355 167600 12618 34776358
Epstein-Barr virus infection 314.03 12.77 274 167681 7354 34781622
Diffuse large B-cell lymphoma 303.94 12.77 265 167690 7105 34781871
Adenovirus infection 301.23 12.77 229 167726 5028 34783948
Septic shock 295.31 12.77 886 167069 70948 34718028
Fatigue 289.39 12.77 871 167084 369782 34419194
White blood cell count decreased 280.29 12.77 1051 166904 94394 34694582
Disease recurrence 278.49 12.77 424 167531 21066 34767910
Myocardial infarction 276.15 12.77 118 167837 120967 34668009
Cardiotoxicity 271.85 12.77 222 167733 5426 34783550
Neoplasm progression 264.98 12.77 433 167522 22867 34766109
Leukopenia 263.75 12.77 781 167174 62075 34726901
Graft versus host disease in skin 263.25 12.77 188 167767 3737 34785239
Overdose 260.72 12.77 59 167896 91000 34697976
Anxiety 249.92 12.77 83 167872 99345 34689631
Acute lymphocytic leukaemia recurrent 244.68 12.77 163 167792 2881 34786095
Aspergillus infection 244.30 12.77 298 167657 11956 34777020
Lymphopenia 243.04 12.77 344 167611 15991 34772985
Dyspnoea 242.89 12.77 961 166994 375821 34413155
Post transplant lymphoproliferative disorder 240.02 12.77 220 167735 6308 34782668
Platelet count decreased 237.73 12.77 1171 166784 118546 34670430
Pain 235.61 12.77 388 167567 204287 34584689
Graft versus host disease in gastrointestinal tract 230.13 12.77 169 167786 3514 34785462
Rash 223.77 12.77 459 167496 222293 34566683
Lymphadenopathy 220.64 12.77 448 167507 28015 34760961
Rhabdomyolysis 219.02 12.77 33 167922 68130 34720846
Diffuse large B-cell lymphoma refractory 211.68 12.77 109 167846 1157 34787819
Insomnia 208.59 12.77 120 167835 103787 34685189
Pruritus 208.23 12.77 225 167730 141756 34647220
Malaise 206.69 12.77 360 167595 185465 34603511
Thrombotic microangiopathy 204.63 12.77 254 167701 10376 34778600
Inappropriate schedule of product administration 200.52 12.77 30 167925 62266 34726710
Malignant neoplasm progression 199.39 12.77 895 167060 87151 34701825
Blood pressure increased 198.99 12.77 87 167868 88015 34700961
Bronchopulmonary aspergillosis 198.12 12.77 295 167660 14364 34774612
Cytomegalovirus chorioretinitis 191.77 12.77 150 167805 3439 34785537
Depression 188.06 12.77 117 167838 96981 34691995
Somnolence 187.61 12.77 155 167800 110961 34678015
Multiple organ dysfunction syndrome 180.67 12.77 788 167167 75778 34713198
B-cell lymphoma recurrent 178.55 12.77 84 167871 720 34788256
Infection 178.01 12.77 886 167069 90029 34698947
Pain in extremity 175.13 12.77 210 167745 126303 34662673
Feeling abnormal 175.00 12.77 44 167911 63191 34725785
Mantle cell lymphoma recurrent 170.32 12.77 80 167875 683 34788293
Respiratory failure 169.84 12.77 995 166960 107577 34681399
Joint swelling 169.00 12.77 40 167915 59850 34729126
Acquired gene mutation 168.87 12.77 96 167859 1259 34787717
Intentional product misuse 166.76 12.77 14 167941 45597 34743379
Muscle spasms 164.76 12.77 77 167878 74924 34714052
Suicidal ideation 163.90 12.77 7 167948 40381 34748595
Neuropathy peripheral 162.67 12.77 811 167144 82452 34706524
Cytomegalovirus viraemia 158.44 12.77 187 167768 7243 34781733
Death 158.02 12.77 1193 166762 396856 34392120
Suicide attempt 158.00 12.77 7 167948 39109 34749867
Chest pain 154.52 12.77 231 167724 126531 34662445
Peripheral swelling 154.14 12.77 88 167867 76453 34712523
Polyneuropathy 150.97 12.77 263 167692 14633 34774343
Lymphocyte count decreased 150.93 12.77 335 167620 22287 34766689
Gait disturbance 149.67 12.77 114 167841 85026 34703950
Blood glucose increased 147.31 12.77 68 167887 66650 34722326
Fungal infection 146.96 12.77 270 167685 15665 34773311
Hospitalisation 143.79 12.77 47 167908 56855 34732121
Herpes simplex 140.81 12.77 153 167802 5406 34783570
Acute graft versus host disease in intestine 140.00 12.77 111 167844 2597 34786379
Weight increased 139.02 12.77 145 167810 92888 34696088
Candida infection 138.65 12.77 280 167675 17435 34771541
Blood lactate dehydrogenase increased 138.50 12.77 327 167628 22663 34766313
Musculoskeletal stiffness 138.14 12.77 28 167927 46652 34742324
Aggression 136.99 12.77 14 167941 38950 34750026
Lymphoma 134.88 12.77 227 167728 12280 34776696
Coronary artery disease 134.84 12.77 33 167922 48272 34740704
JC virus infection 132.74 12.77 99 167856 2109 34786867
Psoriasis 131.27 12.77 16 167939 38796 34750180
Cerebrovascular accident 130.34 12.77 129 167826 84682 34704294
Toxicity to various agents 129.28 12.77 510 167445 199852 34589124
B-cell type acute leukaemia 128.21 12.77 51 167904 275 34788701
Plasma cell myeloma recurrent 127.51 12.77 131 167824 4334 34784642
Viral haemorrhagic cystitis 126.95 12.77 76 167879 1104 34787872
Hyperhidrosis 125.96 12.77 107 167848 75585 34713391
Injection site pain 125.00 12.77 19 167936 38986 34749990
Aplasia 124.54 12.77 131 167824 4457 34784519
Neoplasm recurrence 124.52 12.77 96 167859 2153 34786823
Therapy non-responder 122.23 12.77 440 167515 38706 34750270
Myalgia 121.32 12.77 135 167820 83975 34705001
Loss of consciousness 121.09 12.77 131 167824 82536 34706440
Stress 120.72 12.77 6 167949 30341 34758635
Headache 119.92 12.77 526 167429 200109 34588867
Drug resistance 119.13 12.77 333 167622 25594 34763382
Hypoglycaemia 118.60 12.77 57 167898 54583 34734393
Pseudomonas infection 118.24 12.77 213 167742 12169 34776807
Epstein-Barr virus associated lymphoproliferative disorder 117.94 12.77 88 167867 1876 34787100
Hallucination 117.59 12.77 50 167905 51448 34737528
Sweat gland tumour 116.77 12.77 52 167903 387 34788589
Nasopharyngitis 116.31 12.77 99 167856 69869 34719107
Weight decreased 116.10 12.77 445 167510 175856 34613120
Engraftment syndrome 114.56 12.77 67 167888 930 34788046
Asthenia 114.48 12.77 700 167255 244551 34544425
Drug hypersensitivity 114.23 12.77 131 167824 80398 34708578
Agranulocytosis 113.46 12.77 310 167645 23511 34765465
Stem cell transplant 113.42 12.77 89 167866 2050 34786926
Incorrect dose administered 112.45 12.77 28 167927 40487 34748489
Bacteraemia 109.72 12.77 272 167683 19445 34769531
Abdominal discomfort 109.18 12.77 77 167878 59758 34729218
Drug ineffective 107.24 12.77 2910 165045 453841 34335135
Loss of personal independence in daily activities 106.69 12.77 16 167939 33163 34755813
End stage renal disease 105.24 12.77 168 167787 8693 34780283
Systemic mycosis 104.69 12.77 75 167880 1498 34787478
Pneumonia fungal 103.35 12.77 148 167807 6952 34782024
Cystitis viral 102.18 12.77 51 167904 504 34788472
Urticaria 101.56 12.77 90 167865 62287 34726689
Nausea 101.28 12.77 1095 166860 338813 34450163
Rheumatoid arthritis 101.25 12.77 29 167926 38209 34750767
Wrong technique in product usage process 99.62 12.77 25 167930 35961 34753015
Heart rate decreased 98.28 12.77 17 167938 31728 34757248
Human herpesvirus 6 infection 96.38 12.77 80 167875 2001 34786975
Hepatic failure 96.03 12.77 374 167581 34157 34754819
Pneumonia cytomegaloviral 95.28 12.77 94 167861 2960 34786016
Chronic graft versus host disease in skin 95.21 12.77 59 167896 915 34788061
Escherichia infection 94.75 12.77 154 167801 8091 34780885
Chronic lymphocytic leukaemia recurrent 94.65 12.77 44 167911 366 34788610
Chronic obstructive pulmonary disease 94.58 12.77 59 167896 48859 34740117
Lymphoproliferative disorder 93.75 12.77 89 167866 2670 34786306
Leukoencephalopathy 93.06 12.77 108 167847 4107 34784869
Pneumonia 92.96 12.77 2338 165617 360289 34428687
Klebsiella infection 92.20 12.77 155 167800 8376 34780600
Diarrhoea 92.15 12.77 1320 166635 388592 34400384
Bradycardia 91.28 12.77 138 167817 75280 34713696
Blood creatine phosphokinase increased 91.10 12.77 51 167904 44806 34744170
Chest discomfort 90.81 12.77 77 167878 54453 34734523
Cytomegalovirus test positive 89.89 12.77 102 167853 3784 34785192
International normalised ratio increased 88.88 12.77 59 167896 47268 34741708
Osteonecrosis 88.81 12.77 211 167744 14679 34774297
Contusion 88.46 12.77 32 167923 36332 34752644
Central nervous system lymphoma 87.36 12.77 57 167898 971 34788005
Cardiac failure congestive 87.34 12.77 167 167788 83103 34705873
Hyperkalaemia 86.88 12.77 124 167831 69265 34719711
Drug ineffective for unapproved indication 86.67 12.77 281 167674 23434 34765542
Minimal residual disease 85.93 12.77 42 167913 395 34788581
Back pain 84.97 12.77 300 167655 121489 34667487
Confusional state 84.20 12.77 381 167574 143779 34645197
Dry skin 84.19 12.77 23 167932 31264 34757712
Escherichia sepsis 83.55 12.77 108 167847 4596 34784380
Bacterial sepsis 83.20 12.77 114 167841 5136 34783840
Acute lymphocytic leukaemia 83.13 12.77 87 167868 2942 34786034
Stomatitis 82.16 12.77 413 167542 42101 34746875
Product prescribing error 81.21 12.77 8 167947 22919 34766057
Graft versus host disease in liver 80.40 12.77 59 167896 1225 34787751
Sleep disorder 80.34 12.77 26 167929 31662 34757314
Arthropathy 79.89 12.77 16 167939 26891 34762085
Autoimmune haemolytic anaemia 79.50 12.77 103 167852 4393 34784583
Mucormycosis 79.45 12.77 119 167836 5823 34783153
Asthma 78.99 12.77 54 167901 42602 34746374
Clostridium difficile colitis 78.21 12.77 208 167747 15522 34773454
Cerebral toxoplasmosis 77.30 12.77 65 167890 1656 34787320
Plasmacytoma 77.21 12.77 92 167863 3599 34785377
Syncope 76.75 12.77 207 167748 91244 34697732
Agitation 76.48 12.77 98 167857 57301 34731675
Aplastic anaemia 75.34 12.77 153 167802 9563 34779413
Sedation 75.27 12.77 7 167948 20999 34767977
Infection reactivation 74.44 12.77 60 167895 1438 34787538
Epstein-Barr virus infection reactivation 74.31 12.77 53 167902 1051 34787925
Acute graft versus host disease in liver 74.19 12.77 61 167894 1505 34787471
Accidental overdose 74.11 12.77 6 167949 20134 34768842
Bacterial infection 73.36 12.77 214 167741 16849 34772127
Wheezing 73.28 12.77 55 167900 41347 34747629
Leukaemia recurrent 72.55 12.77 61 167894 1554 34787422
Neutropenic colitis 71.83 12.77 82 167873 3062 34785914
Transplant failure 71.77 12.77 87 167868 3466 34785510
Tremor 71.53 12.77 184 167771 82403 34706573
Enterococcal infection 71.51 12.77 146 167809 9160 34779816
Nephropathy toxic 71.45 12.77 175 167780 12413 34776563
Heart rate increased 70.58 12.77 71 167884 46272 34742704
Epstein-Barr viraemia 70.45 12.77 55 167900 1257 34787719
Angioedema 69.62 12.77 47 167908 37327 34751649
Hepatotoxicity 69.18 12.77 244 167711 21241 34767735
Injury 68.80 12.77 9 167946 20678 34768298
Drug dependence 68.64 12.77 16 167939 24201 34764775
Mobility decreased 67.58 12.77 30 167925 30098 34758878
Erythema 67.17 12.77 211 167744 88569 34700407
Skin toxicity 67.11 12.77 98 167857 4686 34784290
Abdominal pain upper 66.86 12.77 153 167802 71337 34717639
Anaemia 65.81 12.77 1525 166430 231810 34557166
Swelling 65.56 12.77 64 167891 42302 34746674
Staphylococcal bacteraemia 65.42 12.77 133 167822 8319 34780657
Chloroma 64.83 12.77 37 167918 489 34788487
Rhinovirus infection 64.61 12.77 91 167864 4208 34784768
Gastrointestinal toxicity 63.97 12.77 72 167883 2647 34786329
Nephrolithiasis 63.76 12.77 33 167922 30300 34758676
Balance disorder 63.39 12.77 61 167894 40593 34748383
Peripheral T-cell lymphoma unspecified 62.91 12.77 35 167920 439 34788537
Psoriatic arthropathy 62.62 12.77 10 167945 19788 34769188
Psychotic disorder 62.10 12.77 20 167935 24432 34764544
Memory impairment 61.91 12.77 70 167885 43248 34745728
Constipation 61.69 12.77 395 167560 136587 34652389
Gastrooesophageal reflux disease 61.38 12.77 55 167900 37869 34751107
Anaplastic lymphoma kinase gene mutation 61.27 12.77 23 167932 103 34788873
Blood stem cell transplant failure 61.09 12.77 33 167922 389 34788587
Varicella zoster virus infection 60.87 12.77 58 167897 1748 34787228
Staphylococcal sepsis 60.34 12.77 141 167814 9703 34779273
Cytogenetic abnormality 60.31 12.77 43 167912 852 34788124
Product quality issue 60.19 12.77 6 167949 17029 34771947
Osteosarcoma 60.14 12.77 29 167926 264 34788712
Flushing 60.08 12.77 41 167914 32379 34756597
Strongyloidiasis 59.07 12.77 69 167886 2642 34786334
Refractory cytopenia with multilineage dysplasia 58.91 12.77 23 167932 117 34788859
Parainfluenzae virus infection 58.31 12.77 70 167885 2760 34786216
Dehydration 56.89 12.77 378 167577 129591 34659385
Hypersensitivity 55.96 12.77 132 167823 60903 34728073
Refractory anaemia with an excess of blasts 55.92 12.77 31 167924 386 34788590
Chronic graft versus host disease in liver 55.80 12.77 32 167923 427 34788549
Acute myeloid leukaemia recurrent 55.44 12.77 60 167895 2110 34786866
Klebsiella sepsis 55.00 12.77 58 167897 1979 34786997
Enterococcal bacteraemia 54.79 12.77 56 167899 1841 34787135
Decreased appetite 54.75 12.77 523 167432 165869 34623107
Heart rate irregular 54.73 12.77 6 167949 15801 34773175
Pseudomonal sepsis 54.68 12.77 76 167879 3471 34785505
Fusarium infection 54.57 12.77 45 167910 1115 34787861
Electrocardiogram QT prolonged 54.46 12.77 70 167885 40882 34748094
Blood fibrinogen decreased 54.31 12.77 46 167909 1184 34787792
Treatment noncompliance 54.16 12.77 34 167921 28066 34760910
Nocardiosis 54.07 12.77 80 167875 3871 34785105
Lung infiltration 53.71 12.77 160 167795 12745 34776231
Myelopathy 53.49 12.77 63 167892 2434 34786542
Labelled drug-drug interaction medication error 53.47 12.77 5 167950 14934 34774042
Hot flush 53.10 12.77 11 167944 18055 34770921
Cytokine increased 53.08 12.77 16 167939 29 34788947
Treatment failure 52.87 12.77 395 167560 46302 34742674
Abnormal behaviour 52.73 12.77 27 167928 24942 34764034
Central nervous system fungal infection 52.43 12.77 28 167927 322 34788654
Microsporidia infection 52.43 12.77 36 167919 670 34788306
Synovitis 52.29 12.77 4 167951 14062 34774914
Blood pressure fluctuation 52.29 12.77 28 167927 25221 34763755
Cardiac disorder 52.08 12.77 79 167876 43047 34745929
Plasma cell myeloma refractory 52.02 12.77 34 167921 581 34788395
Unevaluable event 51.86 12.77 48 167907 32542 34756434
B-cell aplasia 51.83 12.77 20 167935 98 34788878
Toxoplasmosis 51.61 12.77 46 167909 1270 34787706
Polyomavirus viraemia 51.58 12.77 40 167915 905 34788071
Oedema peripheral 51.16 12.77 351 167604 119461 34669515
Nightmare 51.02 12.77 5 167950 14386 34774590
Malignant transformation 50.81 12.77 38 167917 813 34788163
Human polyomavirus infection 50.73 12.77 36 167919 708 34788268
Dyspepsia 50.72 12.77 61 167894 36671 34752305
Palpitations 50.49 12.77 71 167884 39915 34749061
Injection site erythema 50.35 12.77 8 167947 15891 34773085
Bone marrow transplant rejection 50.24 12.77 23 167932 184 34788792
Disseminated intravascular coagulation 50.21 12.77 223 167732 21593 34767383
Device related infection 49.80 12.77 189 167766 17048 34771928
Interstitial lung disease 49.76 12.77 506 167449 64776 34724200
Blood pressure systolic increased 49.70 12.77 24 167931 22928 34766048
Lymphoma transformation 49.66 12.77 25 167930 252 34788724
Encephalopathy 49.61 12.77 315 167640 35004 34753972
Recurrent cancer 49.54 12.77 46 167909 1341 34787635
Head injury 49.52 12.77 13 167942 18147 34770829
Bone marrow infiltration 49.51 12.77 23 167932 191 34788785
Plasma cell leukaemia 49.45 12.77 39 167916 905 34788071
Febrile infection 49.39 12.77 57 167898 2154 34786822
Vertigo 49.07 12.77 31 167924 25505 34763471
Restlessness 48.88 12.77 31 167924 25451 34763525
Candida sepsis 48.77 12.77 44 167911 1235 34787741
Cardio-respiratory arrest 48.73 12.77 122 167833 55151 34733825
Amnesia 48.68 12.77 34 167921 26529 34762447
Nervousness 48.56 12.77 3 167952 12603 34776373
Herpes virus infection 48.53 12.77 64 167891 2778 34786198
Cardiomyopathy 48.31 12.77 184 167771 16624 34772352
Multiple sclerosis relapse 48.08 12.77 4 167951 13129 34775847
Primary hypogonadism 48.01 12.77 17 167938 62 34788914
Herpes zoster 47.82 12.77 306 167649 34093 34754883
Medication error 47.81 12.77 32 167923 25533 34763443
Lactic acidosis 47.74 12.77 58 167897 34714 34754262
Drug reaction with eosinophilia and systemic symptoms 47.55 12.77 53 167902 32959 34756017
Respiratory arrest 47.41 12.77 39 167916 28004 34760972
Metabolic acidosis 47.19 12.77 86 167869 43594 34745382
Cardiac arrest 47.09 12.77 270 167685 95889 34693087
Encephalitis cytomegalovirus 47.05 12.77 32 167923 586 34788390
Colitis ulcerative 46.65 12.77 11 167944 16509 34772467
B-cell lymphoma refractory 46.52 12.77 21 167934 162 34788814
Azoospermia 46.40 12.77 28 167927 413 34788563
Pleural effusion 46.36 12.77 597 167358 80949 34708027
Acute myelomonocytic leukaemia 46.09 12.77 19 167936 114 34788862
Enterovirus infection 45.86 12.77 38 167917 948 34788028
Abdominal distension 45.66 12.77 137 167818 58355 34730621
Osteoarthritis 45.60 12.77 21 167934 20621 34768355
Respiratory depression 45.51 12.77 11 167944 16234 34772742
Pneumocystis jirovecii infection 45.32 12.77 49 167906 1721 34787255
Depressed mood 45.30 12.77 18 167937 19299 34769677
Adenovirus reactivation 45.28 12.77 22 167933 204 34788772
Anger 45.27 12.77 3 167952 11881 34777095
Bone marrow necrosis 45.14 12.77 21 167934 175 34788801
Swollen tongue 44.81 12.77 8 167947 14597 34774379
Influenza like illness 44.81 12.77 40 167915 27594 34761382
Epstein-Barr virus associated lymphoma 44.80 12.77 32 167923 636 34788340
Haematochezia 44.80 12.77 98 167857 46436 34742540
Transient ischaemic attack 44.74 12.77 40 167915 27573 34761403
Irritability 44.72 12.77 32 167923 24658 34764318
Gastrosplenic fistula 43.62 12.77 15 167940 49 34788927
Liver function test abnormal 43.55 12.77 51 167904 31023 34757953
Blood glucose decreased 43.44 12.77 6 167949 13231 34775745
Dysgeusia 43.39 12.77 38 167917 26459 34762517
Coma 43.31 12.77 97 167858 45581 34743395
Human herpesvirus 6 encephalitis 43.18 12.77 25 167930 340 34788636
Neck pain 43.17 12.77 35 167920 25314 34763662
Musculoskeletal pain 43.16 12.77 54 167901 31909 34757067
Surgery 42.91 12.77 8 167947 14149 34774827
Clear cell renal cell carcinoma 42.83 12.77 39 167916 1108 34787868
Adenoviral haemorrhagic cystitis 42.82 12.77 26 167929 388 34788588
Therapeutic product effect decreased 42.57 12.77 63 167892 34680 34754296
Chronic myeloid leukaemia 42.57 12.77 53 167902 2171 34786805
Adverse drug reaction 42.38 12.77 47 167908 29295 34759681
Dyskinesia 41.99 12.77 28 167927 22385 34766591
Dry mouth 41.75 12.77 50 167905 30115 34758861
Frequent bowel movements 41.49 12.77 6 167949 12781 34776195
Hepatosplenomegaly 41.44 12.77 73 167882 4096 34784880
Engraft failure 41.38 12.77 27 167928 460 34788516
Road traffic accident 41.35 12.77 16 167939 17434 34771542
Oxygen saturation decreased 41.33 12.77 127 167828 53691 34735285
Pneumonia klebsiella 41.17 12.77 64 167891 3236 34785740
Staphylococcal infection 41.06 12.77 284 167671 32476 34756500
Prostatic specific antigen increased 41.01 12.77 10 167945 14670 34774306
5q minus syndrome 40.99 12.77 18 167937 129 34788847
Pneumonitis 40.89 12.77 291 167664 33587 34755389
Injection site swelling 40.88 12.77 4 167951 11523 34777453
Vision blurred 40.87 12.77 101 167854 45862 34743114
Delusion 40.83 12.77 6 167949 12629 34776347
Autoimmune neutropenia 40.75 12.77 22 167933 259 34788717
Peripheral sensory neuropathy 40.53 12.77 96 167859 6664 34782312
Emotional distress 40.51 12.77 11 167944 15015 34773961
Acute myocardial infarction 40.38 12.77 128 167827 53591 34735385
Capillary leak syndrome 40.35 12.77 52 167903 2206 34786770
Arthritis 40.23 12.77 55 167900 31291 34757685
Respiratory tract infection fungal 40.18 12.77 31 167924 696 34788280
Ventricular tachycardia 40.14 12.77 41 167914 26538 34762438
Obliterative bronchiolitis 39.89 12.77 39 167916 1214 34787762
Extrapyramidal disorder 39.64 12.77 7 167948 12873 34776103
Peritonitis pneumococcal 39.38 12.77 12 167943 23 34788953
Granulocyte count decreased 39.14 12.77 32 167923 783 34788193
Respiratory tract infection 39.13 12.77 193 167762 19519 34769457
B-lymphocyte count decreased 39.03 12.77 29 167926 614 34788362
Flatulence 39.02 12.77 27 167928 21171 34767805
Encephalitis 39.02 12.77 99 167856 7178 34781798
Neoplasm 38.77 12.77 83 167872 5384 34783592
Pulmonary toxicity 38.72 12.77 89 167866 6058 34782918
COVID-19 pneumonia 38.72 12.77 173 167782 16794 34772182
Burning sensation 38.67 12.77 20 167935 18374 34770602
Hypofibrinogenaemia 38.56 12.77 44 167911 1642 34787334
Rectal haemorrhage 38.55 12.77 85 167870 40164 34748812
Nervous system disorder 38.39 12.77 155 167800 14388 34774588
Erectile dysfunction 38.37 12.77 26 167929 20611 34768365
Complications of bone marrow transplant 38.14 12.77 20 167935 221 34788755
Human herpesvirus 8 infection 38.08 12.77 34 167921 941 34788035
Myocardial ischaemia 38.00 12.77 18 167937 17390 34771586
Therapy cessation 37.91 12.77 17 167938 16956 34772020
B-cell lymphoma 37.81 12.77 72 167883 4291 34784685
Thymus enlargement 37.68 12.77 13 167942 43 34788933
Diabetic ketoacidosis 37.33 12.77 20 167935 18012 34770964
Escherichia bacteraemia 37.33 12.77 61 167894 3219 34785757
Sleep apnoea syndrome 37.25 12.77 26 167929 20295 34768681
Pulmonary veno-occlusive disease 36.74 12.77 26 167929 509 34788467
Systemic candida 36.72 12.77 65 167890 3661 34785315
Refractory cancer 36.71 12.77 17 167938 140 34788836
Gastritis bacterial 36.71 12.77 19 167936 204 34788772
Gastrointestinal haemorrhage 36.38 12.77 262 167693 88215 34700761
Nodular regenerative hyperplasia 36.17 12.77 33 167922 940 34788036
Gene mutation 36.09 12.77 39 167916 1369 34787607
Hypoaesthesia 36.05 12.77 162 167793 61282 34727694
Guillain-Barre syndrome 36.02 12.77 86 167869 6001 34782975
Unresponsive to stimuli 35.76 12.77 48 167907 27521 34761455
Ocular hyperaemia 35.73 12.77 6 167949 11446 34777530
Acute monocytic leukaemia 35.62 12.77 22 167933 339 34788637
Primary amyloidosis 35.60 12.77 16 167939 122 34788854
Acute kidney injury 35.52 12.77 1156 166799 303832 34485144
Pneumomediastinum 35.42 12.77 50 167905 2317 34786659
Clostridium difficile infection 35.38 12.77 182 167773 18716 34770260
Gallbladder oedema 35.24 12.77 19 167936 223 34788753
Skin discolouration 35.21 12.77 21 167934 17824 34771152
Discomfort 35.02 12.77 24 167931 18914 34770062
Gait inability 34.93 12.77 29 167926 20729 34768247
Pneumonia adenoviral 34.75 12.77 22 167933 355 34788621
Thrombosis 34.67 12.77 125 167830 50333 34738643
Prescribed overdose 34.53 12.77 5 167950 10642 34778334
Meningoencephalitis herpetic 34.37 12.77 30 167925 805 34788171
Traumatic lung injury 34.24 12.77 36 167919 1224 34787752
Paranoia 34.14 12.77 8 167947 12060 34776916
Immunosuppression 34.05 12.77 86 167869 6218 34782758
Fear 33.79 12.77 5 167950 10471 34778505
Aphasia 33.70 12.77 197 167758 21257 34767719
Intestinal perforation 33.68 12.77 108 167847 8952 34780024
Encephalitis enteroviral 33.63 12.77 16 167939 141 34788835
Encephalitis viral 33.60 12.77 35 167920 1177 34787799
Myelitis transverse 33.56 12.77 34 167921 1106 34787870
Hypertriglyceridaemia 33.52 12.77 103 167852 8345 34780631
Adverse event 33.49 12.77 25 167930 18852 34770124
Colitis 33.40 12.77 302 167653 37448 34751528
Therapy interrupted 33.40 12.77 12 167943 13685 34775291
Respirovirus test positive 33.32 12.77 13 167942 66 34788910
Wound 33.02 12.77 15 167940 14849 34774127
Blood cholesterol increased 32.99 12.77 30 167925 20513 34768463
B-lymphocyte count abnormal 32.89 12.77 9 167946 9 34788967
Type 2 diabetes mellitus 32.87 12.77 18 167937 16014 34772962
Polyomavirus-associated nephropathy 32.78 12.77 63 167892 3781 34785195
Illness 32.74 12.77 12 167943 13517 34775459
Bone marrow disorder 32.65 12.77 41 167914 1694 34787282
Chronic lymphocytic leukaemia transformation 32.64 12.77 17 167938 185 34788791
Dyspnoea exertional 32.61 12.77 103 167852 43176 34745800
Sopor 32.50 12.77 9 167946 12127 34776849
Neuroblastoma 32.49 12.77 17 167938 187 34788789
Myeloid leukaemia 32.43 12.77 22 167933 401 34788575
Stenotrophomonas infection 32.21 12.77 45 167910 2065 34786911
Skin laceration 32.17 12.77 10 167945 12499 34776477
Actinomycosis 32.16 12.77 23 167932 458 34788518
Human herpesvirus 6 infection reactivation 32.15 12.77 16 167939 157 34788819
Cardiogenic shock 31.90 12.77 49 167906 26569 34762407
Pulmonary arteriopathy 31.82 12.77 13 167942 76 34788900
Pneumonia respiratory syncytial viral 31.79 12.77 30 167925 893 34788083
Hypersomnia 31.77 12.77 10 167945 12397 34776579
Graft versus host disease in eye 31.66 12.77 18 167937 236 34788740
Out of specification test results 31.52 12.77 11 167944 38 34788938
Glycosylated haemoglobin increased 31.23 12.77 8 167947 11352 34777624
Acute promyelocytic leukaemia 31.16 12.77 23 167932 482 34788494
Abdominal pain 31.12 12.77 576 167379 163042 34625934
Poisoning 31.04 12.77 10 167945 12216 34776760
Disturbance in attention 30.86 12.77 48 167907 25897 34763079
Eye pain 30.83 12.77 13 167942 13449 34775527
Pneumonia viral 30.81 12.77 55 167900 3119 34785857
Pemphigoid 30.75 12.77 3 167952 8663 34780313
Pulmonary vascular disorder 30.74 12.77 26 167929 668 34788308
Eczema 30.72 12.77 26 167929 18410 34770566
Acute respiratory distress syndrome 30.72 12.77 222 167733 25747 34763229
Limb injury 30.69 12.77 9 167946 11680 34777296
Acute lymphocytic leukaemia refractory 30.69 12.77 14 167941 111 34788865
Enterococcal sepsis 30.66 12.77 39 167916 1633 34787343
Neuroblastoma recurrent 30.51 12.77 15 167940 143 34788833
Presyncope 30.41 12.77 28 167927 19031 34769945
Cholelithiasis 30.40 12.77 34 167921 21114 34767862
Lymphoid tissue hypoplasia 30.30 12.77 21 167934 397 34788579
Thymus hypoplasia 30.30 12.77 21 167934 397 34788579
Psychomotor hyperactivity 30.11 12.77 5 167950 9617 34779359
Coronary artery stenosis 30.09 12.77 5 167950 9611 34779365
Congenital cardiovascular anomaly 29.96 12.77 16 167939 184 34788792
Limb discomfort 29.94 12.77 8 167947 11039 34777937
Multiple-drug resistance 29.91 12.77 73 167882 5166 34783810
Paraparesis 29.91 12.77 41 167914 1848 34787128
Therapeutic response decreased 29.87 12.77 242 167713 29071 34759905
Hallucination, visual 29.76 12.77 25 167930 17766 34771210
Melaena 29.72 12.77 80 167875 35300 34753676
Ototoxicity 29.44 12.77 41 167914 1876 34787100
Glioblastoma multiforme 29.35 12.77 26 167929 712 34788264
Cough 29.35 12.77 526 167429 149614 34639362
Panic attack 29.30 12.77 5 167950 9427 34779549
Hyponatraemia 29.29 12.77 255 167700 82436 34706540
Serum ferritin increased 29.27 12.77 80 167875 6066 34782910
Joint stiffness 29.24 12.77 8 167947 10865 34778111
Haemorrhage 29.20 12.77 137 167818 51233 34737743
Lower respiratory tract infection fungal 29.12 12.77 24 167931 594 34788382
Meningitis cryptococcal 29.12 12.77 46 167909 2358 34786618
Blindness cortical 29.09 12.77 20 167935 373 34788603
Iron deficiency anaemia 28.92 12.77 7 167948 10322 34778654
Lip swelling 28.91 12.77 21 167934 16059 34772917
Delirium 28.90 12.77 111 167844 43880 34745096
H1N1 influenza 28.88 12.77 29 167926 933 34788043
Acute erythroid leukaemia 28.82 12.77 15 167940 163 34788813
Hyperlipidaemia 28.80 12.77 17 167938 14512 34774464
Hypertensive crisis 28.64 12.77 4 167951 8747 34780229
Platelet transfusion 28.62 12.77 36 167919 1490 34787486
Therapy responder 28.43 12.77 15 167940 168 34788808
Product storage error 28.33 12.77 3 167952 8119 34780857
Accidental exposure to product 28.31 12.77 13 167942 12789 34776187
Transformation to acute myeloid leukaemia 28.28 12.77 26 167929 748 34788228
Akathisia 28.27 12.77 3 167952 8106 34780870
Hypoxia 28.26 12.77 396 167559 54699 34734277
Graft versus host disease in lung 28.19 12.77 23 167932 561 34788415
Metastases to spleen 28.13 12.77 21 167934 448 34788528
Disseminated aspergillosis 28.11 12.77 26 167929 754 34788222
Feeling hot 28.01 12.77 31 167924 19341 34769635
Steroid diabetes 27.98 12.77 43 167912 2152 34786824
Meningitis enteroviral 27.78 12.77 9 167946 23 34788953
Fungal sepsis 27.71 12.77 27 167928 837 34788139
Organic brain syndrome 27.69 12.77 17 167938 259 34788717
Hypertension 27.62 12.77 475 167480 135968 34653008
Adenoviral hepatitis 27.48 12.77 22 167933 522 34788454
Large intestine polyp 27.41 12.77 3 167952 7911 34781065
Chromaturia 27.39 12.77 18 167937 14502 34774474
Rash pruritic 27.38 12.77 55 167900 26886 34762090
Neurological decompensation 27.02 12.77 50 167905 2916 34786060
Ageusia 26.95 12.77 8 167947 10300 34778676
Autoimmune lymphoproliferative syndrome 26.91 12.77 14 167941 152 34788824
Urinary tract infection 26.88 12.77 266 167689 83815 34705161
Hepatosplenic candidiasis 26.87 12.77 16 167939 230 34788746
Nasal cavity cancer 26.83 12.77 15 167940 190 34788786
Herpes simplex encephalitis 26.83 12.77 18 167937 322 34788654
Molluscum contagiosum 26.81 12.77 17 167938 275 34788701
Ill-defined disorder 26.77 12.77 135 167820 13774 34775202
Stevens-Johnson syndrome 26.76 12.77 30 167925 18609 34770367
Hip fracture 26.54 12.77 12 167943 11913 34777063
Visual impairment 26.42 12.77 86 167869 35716 34753260
Swelling face 26.31 12.77 44 167911 23061 34765915
Splenic candidiasis 26.28 12.77 11 167944 69 34788907
Skin exfoliation 26.21 12.77 58 167897 27374 34761602
Aspiration bone marrow abnormal 26.17 12.77 13 167942 127 34788849
Underdose 26.10 12.77 17 167938 13763 34775213
Candida pneumonia 26.07 12.77 20 167935 445 34788531
Hepatic enzyme increased 26.07 12.77 98 167857 38982 34749994
Neurofibrosarcoma 26.03 12.77 9 167946 30 34788946
Faeces discoloured 26.02 12.77 20 167935 14858 34774118
Juvenile melanoma benign 26.02 12.77 11 167944 71 34788905
Muscle rigidity 26.01 12.77 9 167946 10509 34778467
Hernia 25.86 12.77 7 167948 9576 34779400
T-cell lymphoma stage IV 25.83 12.77 13 167942 131 34788845
Glomerulonephritis rapidly progressive 25.81 12.77 23 167932 635 34788341
Blood pressure diastolic decreased 25.79 12.77 6 167949 9088 34779888
Pathogen resistance 25.78 12.77 102 167853 9380 34779596
Pulmonary alveolar haemorrhage 25.65 12.77 87 167868 7425 34781551
Eye disorder 25.64 12.77 7 167948 9521 34779455
Mass 25.64 12.77 90 167865 7815 34781161
Cerebral aspergillosis 25.62 12.77 33 167922 1399 34787577
Plasmablastic lymphoma 25.58 12.77 18 167937 349 34788627
Blood pressure decreased 25.55 12.77 144 167811 51371 34737605
Glioma 25.49 12.77 18 167937 351 34788625
Hyperbilirubinaemia 25.39 12.77 153 167802 16690 34772286
Alpha haemolytic streptococcal infection 25.37 12.77 30 167925 1164 34787812
Mood altered 25.20 12.77 6 167949 8946 34780030
Splenomegaly 25.18 12.77 141 167814 14976 34774000
Respiratory distress 25.07 12.77 272 167683 35393 34753583
Peripheral motor neuropathy 25.03 12.77 37 167918 1789 34787187
Diabetes mellitus inadequate control 24.98 12.77 17 167938 13447 34775529
Viral sinusitis 24.92 12.77 11 167944 80 34788896
Spinal column injury 24.85 12.77 22 167933 602 34788374
Facial paresis 24.82 12.77 49 167906 3000 34785976
Prostate cancer 24.81 12.77 102 167853 39547 34749429
Chronic lymphocytic leukaemia refractory 24.69 12.77 11 167944 82 34788894
Central nervous system leukaemia 24.65 12.77 16 167939 270 34788706
Lentigo 24.65 12.77 20 167935 484 34788492
Condition aggravated 24.64 12.77 719 167236 191477 34597499
Hepatic infection fungal 24.53 12.77 14 167941 185 34788791
Meningeal neoplasm 24.40 12.77 10 167945 59 34788917
Achromobacter infection 24.26 12.77 10 167945 60 34788916
Post-depletion B-cell recovery 24.24 12.77 7 167948 10 34788966
Migraine 24.15 12.77 29 167926 17449 34771527
Abdominal neoplasm 24.15 12.77 18 167937 383 34788593
Primitive neuroectodermal tumour 24.12 12.77 10 167945 61 34788915
Tendonitis 24.06 12.77 7 167948 9133 34779843
Hepatitis E 24.02 12.77 39 167916 2047 34786929
Oroantral fistula 23.83 12.77 14 167941 196 34788780
Hepatitis viral 23.80 12.77 21 167934 572 34788404
Blood urea increased 23.77 12.77 71 167884 30293 34758683
Arteriosclerosis 23.73 12.77 14 167941 11954 34777022
B precursor type acute leukaemia 23.53 12.77 14 167941 201 34788775
Metastases to bone marrow 23.51 12.77 20 167935 518 34788458
Stenotrophomonas sepsis 23.50 12.77 12 167943 125 34788851
Nasal congestion 23.50 12.77 47 167908 23010 34765966
Incorrect route of product administration 23.46 12.77 22 167933 14823 34774153
Secondary immunodeficiency 23.41 12.77 18 167937 402 34788574
Dementia 23.39 12.77 19 167936 13729 34775247
West Nile viral infection 23.32 12.77 23 167932 724 34788252
Oligohydramnios 23.25 12.77 17 167938 351 34788625
Carbohydrate antigen 15-3 increased 23.22 12.77 10 167945 68 34788908
Streptococcal infection 23.05 12.77 64 167891 4897 34784079
Escherichia test positive 23.01 12.77 28 167927 1120 34787856
Adenocarcinoma gastric 22.99 12.77 29 167926 1204 34787772
Cytomegalovirus colitis 22.97 12.77 45 167910 2739 34786237
Neutropenic infection 22.94 12.77 32 167923 1466 34787510
Gastrointestinal wall thickening 22.94 12.77 32 167923 1466 34787510
Coronary artery occlusion 22.92 12.77 12 167943 10950 34778026
Disseminated cytomegaloviral infection 22.88 12.77 14 167941 212 34788764
Device related thrombosis 22.87 12.77 28 167927 1127 34787849
Metastasis 22.87 12.77 57 167898 4087 34784889
Spermatozoa abnormal 22.86 12.77 9 167946 47 34788929
Leukaemia cutis 22.85 12.77 10 167945 71 34788905
Corynebacterium infection 22.85 12.77 21 167934 604 34788372
Mood swings 22.83 12.77 5 167950 7896 34781080
Rhabdomyosarcoma recurrent 22.83 12.77 11 167944 100 34788876
Thirst 22.80 12.77 5 167950 7890 34781086
Electrocardiogram abnormal 22.72 12.77 8 167947 9239 34779737
Product administration error 22.71 12.77 27 167928 16317 34772659
Dysphonia 22.70 12.77 49 167906 23334 34765642
Pericardial effusion 22.69 12.77 199 167756 24463 34764513
Abdominal lymphadenopathy 22.50 12.77 24 167931 830 34788146
Dystonia 22.49 12.77 12 167943 10833 34778143
Chylothorax 22.46 12.77 23 167932 758 34788218
Device malfunction 22.40 12.77 11 167944 10410 34778566
Antithrombin III decreased 22.40 12.77 16 167939 318 34788658
Respiratory tract infection viral 22.39 12.77 42 167913 2475 34786501
Hepatic candidiasis 22.26 12.77 9 167946 51 34788925
Cellulitis gangrenous 22.25 12.77 13 167942 180 34788796
Metastases to skin 22.24 12.77 18 167937 434 34788542
Humoral immune defect 22.19 12.77 13 167942 181 34788795
Diabetes mellitus 22.19 12.77 133 167822 46740 34742236
Miosis 22.17 12.77 9 167946 9526 34779450
Chronic lymphocytic leukaemia 22.09 12.77 57 167898 4175 34784801
Chronic myelomonocytic leukaemia 22.04 12.77 21 167934 633 34788343
Movement disorder 22.02 12.77 16 167939 12232 34776744
Mucoepidermoid carcinoma 21.86 12.77 7 167948 17 34788959
Pneumaturia 21.83 12.77 8 167947 33 34788943
Rotavirus infection 21.79 12.77 17 167938 388 34788588
Blood creatinine increased 21.76 12.77 323 167632 94653 34694323
Infection in an immunocompromised host 21.63 12.77 21 167934 648 34788328
Blood culture positive 21.54 12.77 61 167894 4722 34784254
Rash macular 21.53 12.77 18 167937 12824 34776152
Tidal volume decreased 21.46 12.77 8 167947 35 34788941
Localised infection 21.44 12.77 32 167923 17555 34771421
Tinnitus 21.38 12.77 40 167915 20078 34768898
Paresis 21.37 12.77 38 167917 2148 34786828
Viral test positive 21.35 12.77 13 167942 195 34788781
Epistaxis 21.35 12.77 178 167777 58073 34730903
Uveitis 21.31 12.77 5 167950 7530 34781446
T-cell type acute leukaemia 21.26 12.77 11 167944 118 34788858
Proctalgia 21.07 12.77 68 167887 5655 34783321
Basophilia 21.01 12.77 6 167949 8 34788968
Haematocrit decreased 20.96 12.77 242 167713 31974 34757002
Enterobacter infection 20.93 12.77 40 167915 2390 34786586
Papilloma viral infection 20.91 12.77 18 167937 474 34788502
Lethargy 20.91 12.77 114 167841 41008 34747968
Drug level increased 20.88 12.77 47 167908 22049 34766927
Haematopoietic stem cell mobilisation 20.87 12.77 12 167943 161 34788815
Pseudomonal bacteraemia 20.79 12.77 30 167925 1419 34787557
Ischaemic cardiomyopathy 20.72 12.77 3 167952 6386 34782590
Salivary gland cancer 20.71 12.77 15 167940 305 34788671
Drug level decreased 20.67 12.77 6 167949 7840 34781136
Pneumatosis intestinalis 20.65 12.77 53 167902 3870 34785106
SARS-CoV-2 test negative 20.64 12.77 25 167930 995 34787981
Human metapneumovirus test positive 20.56 12.77 10 167945 93 34788883
Chronic kidney disease 20.54 12.77 115 167840 41095 34747881
Acne 20.49 12.77 14 167941 11052 34777924
Lymphocytosis 20.48 12.77 41 167914 2536 34786440
Neuroendocrine carcinoma of the skin 20.43 12.77 22 167933 769 34788207
Salivary hypersecretion 20.36 12.77 8 167947 8636 34780340
Blood loss anaemia 20.28 12.77 7 167948 8187 34780789
Anal inflammation 20.26 12.77 28 167927 1272 34787704
Gastric disorder 20.18 12.77 18 167937 12423 34776553
Haemolytic uraemic syndrome 20.15 12.77 38 167917 2248 34786728
Scedosporium infection 20.14 12.77 23 167932 859 34788117
Orthostatic hypotension 20.01 12.77 61 167894 25858 34763118
Pneumonia mycoplasmal 20.01 12.77 20 167935 640 34788336
Enterovesical fistula 19.98 12.77 22 167933 789 34788187
Ventricular fibrillation 19.96 12.77 51 167904 22903 34766073
Therapeutic response unexpected 19.94 12.77 11 167944 9746 34779230
Pulmonary haemorrhage 19.82 12.77 100 167855 10204 34778772
Viraemia 19.79 12.77 27 167928 1211 34787765
Musculoskeletal discomfort 19.79 12.77 7 167948 8061 34780915
Bordetella infection 19.68 12.77 10 167945 103 34788873
T-cell lymphoma 19.39 12.77 24 167931 977 34787999
Inflammatory pseudotumour 19.27 12.77 7 167948 28 34788948
Metastases to meninges 19.27 12.77 29 167926 1425 34787551
Enterobacter sepsis 19.26 12.77 22 167933 822 34788154
Restless legs syndrome 19.24 12.77 8 167947 8346 34780630
Retinal haemorrhage 19.22 12.77 61 167894 5028 34783948
Clostridium colitis 19.11 12.77 27 167928 1252 34787724
Delayed engraftment 19.11 12.77 10 167945 110 34788866
Drug eruption 19.07 12.77 42 167913 19856 34769120
Small intestinal perforation 19.03 12.77 36 167919 2135 34786841
Blister 18.96 12.77 52 167903 22806 34766170
Polyomavirus test positive 18.95 12.77 10 167945 112 34788864
Tooth development disorder 18.90 12.77 6 167949 14 34788962
Cardiac murmur 18.88 12.77 7 167948 7830 34781146
Pulmonary mucormycosis 18.87 12.77 21 167934 762 34788214
Fluid retention 18.87 12.77 66 167889 26821 34762155
Bronchitis 18.86 12.77 121 167834 41842 34747134
Focal nodular hyperplasia 18.85 12.77 11 167944 152 34788824
Granulomatosis with polyangiitis 18.84 12.77 26 167929 1179 34787797
Herpes oesophagitis 18.79 12.77 11 167944 153 34788823
Diaphragm muscle weakness 18.79 12.77 11 167944 153 34788823
Urinary retention 18.78 12.77 100 167855 36188 34752788
Intestinal atresia 18.75 12.77 9 167946 81 34788895
Body temperature decreased 18.68 12.77 21 167934 13013 34775963
Intervertebral disc degeneration 18.66 12.77 4 167951 6413 34782563
Acute polyneuropathy 18.66 12.77 11 167944 155 34788821
Mucosal toxicity 18.66 12.77 13 167942 248 34788728
Viral load increased 18.65 12.77 39 167916 2488 34786488
Secretion discharge 18.63 12.77 3 167952 5902 34783074
Pneumonia pseudomonal 18.63 12.77 51 167904 3871 34785105
Disorientation 18.57 12.77 89 167866 33099 34755877
Anaplastic large-cell lymphoma 18.57 12.77 9 167946 83 34788893
Peripheral T-cell lymphoma unspecified stage IV 18.53 12.77 7 167948 32 34788944
Viral cardiomyopathy 18.53 12.77 7 167948 32 34788944
Pulmonary oedema 18.45 12.77 143 167812 47386 34741590
Blood HIV RNA increased 18.43 12.77 26 167929 1204 34787772
Left ventricular hypertrophy 18.38 12.77 8 167947 8122 34780854
Ileus paralytic 18.36 12.77 67 167888 5930 34783046
Respiratory syncytial virus infection 18.30 12.77 57 167898 4652 34784324
Exophthalmos 18.29 12.77 18 167937 565 34788411
Human rhinovirus test positive 18.26 12.77 12 167943 207 34788769
Evans syndrome 18.26 12.77 13 167942 257 34788719
Marginal zone lymphoma recurrent 18.19 12.77 7 167948 34 34788942
Lymphoplasmacytoid lymphoma/immunocytoma 18.19 12.77 7 167948 34 34788942
Leukaemia 18.15 12.77 56 167899 4547 34784429
Paraesthesia 18.09 12.77 209 167746 63963 34725013
Inhibin B 18.08 12.77 6 167949 17 34788959
Adenocarcinoma of colon 18.04 12.77 46 167909 3345 34785631
Product use issue 17.99 12.77 414 167541 62802 34726174
Pulmonary sarcoidosis 17.95 12.77 18 167937 578 34788398
Post-acute COVID-19 syndrome 17.95 12.77 11 167944 167 34788809
Acute leukaemia 17.95 12.77 25 167930 1144 34787832
Diverticulum 17.92 12.77 6 167949 7153 34781823
Inflammatory myofibroblastic tumour 17.87 12.77 10 167945 127 34788849
Retroperitoneal mass 17.85 12.77 9 167946 91 34788885
Emotional disorder 17.82 12.77 3 167952 5713 34783263
Glomerulosclerosis 17.81 12.77 21 167934 812 34788164
Rubulavirus test positive 17.80 12.77 5 167950 6 34788970
Hepatic amoebiasis 17.69 12.77 8 167947 62 34788914
Tooth deposit 17.68 12.77 9 167946 93 34788883
Organising pneumonia 17.63 12.77 66 167889 5913 34783063
Meningitis tuberculous 17.60 12.77 19 167936 666 34788310
Ventricular extrasystoles 17.60 12.77 19 167936 11989 34776987
Fungal oesophagitis 17.55 12.77 15 167940 391 34788585
Rotator cuff syndrome 17.54 12.77 3 167952 5646 34783330
Ameloblastoma 17.52 12.77 9 167946 95 34788881
Paraneoplastic pemphigus 17.47 12.77 8 167947 64 34788912
Medulloblastoma recurrent 17.47 12.77 8 167947 64 34788912
Cystitis escherichia 17.45 12.77 11 167944 176 34788800
Disorder of orbit 17.44 12.77 9 167946 96 34788880
Hypoproteinaemia 17.43 12.77 35 167920 2169 34786807
Gynaecomastia 17.40 12.77 14 167941 10166 34778810
Adenoviral upper respiratory infection 17.37 12.77 4 167951 0 34788976
Subdural hygroma 17.35 12.77 14 167941 336 34788640
Blood potassium increased 17.35 12.77 33 167922 16462 34772514
Hepatomegaly 17.34 12.77 97 167858 10299 34778677
Acinetobacter infection 17.33 12.77 25 167930 1182 34787794
Eosinophilia 17.33 12.77 66 167889 26156 34762820
Increased appetite 17.29 12.77 7 167948 7422 34781554
Anaphylactic reaction 17.28 12.77 88 167867 32213 34756763
Eating disorder 17.26 12.77 9 167946 8231 34780745
Therapeutic response shortened 17.20 12.77 7 167948 7397 34781579
Cardiac dysfunction 17.16 12.77 36 167919 2302 34786674
Hyperpyrexia 17.16 12.77 40 167915 2748 34786228
Acanthamoeba infection 17.14 12.77 15 167940 404 34788572
Amyloidosis 17.14 12.77 34 167921 2089 34786887
Acute lung injury 17.07 12.77 28 167927 1482 34787494
Haemoglobin abnormal 17.00 12.77 49 167906 3831 34785145
Personality change due to a general medical condition 16.98 12.77 7 167948 42 34788934
Diverticulitis 16.97 12.77 45 167910 19959 34769017
Prescribed underdose 16.95 12.77 11 167944 8922 34780054
Transplantation complication 16.90 12.77 10 167945 142 34788834
Central nervous system enteroviral infection 16.85 12.77 7 167948 43 34788933
Adult T-cell lymphoma/leukaemia 16.84 12.77 10 167945 143 34788833
Rib fracture 16.79 12.77 27 167928 14373 34774603
Positron emission tomogram abnormal 16.78 12.77 10 167945 144 34788832
Eye swelling 16.77 12.77 14 167941 9981 34778995
Pneumonia aspiration 16.77 12.77 125 167830 41778 34747198
Hippocampal sclerosis 16.74 12.77 9 167946 105 34788871
Helicobacter sepsis 16.72 12.77 6 167949 23 34788953
Epstein-Barr virus test positive 16.70 12.77 17 167938 556 34788420
Pleural mass 16.67 12.77 8 167947 72 34788904
Asphyxia 16.64 12.77 6 167949 6829 34782147
Periorbital infection 16.60 12.77 10 167945 147 34788829
Sphingomonas paucimobilis infection 16.58 12.77 7 167948 45 34788931
Metastases to retroperitoneum 16.57 12.77 12 167943 244 34788732
Haematoma 16.56 12.77 65 167890 25540 34763436
Capnocytophaga infection 16.52 12.77 9 167946 108 34788868
Intentional product use issue 16.49 12.77 390 167565 59426 34729550
Angina pectoris 16.47 12.77 86 167869 31277 34757699
Laboratory test abnormal 16.46 12.77 47 167908 20344 34768632
Hepatitis D 16.45 12.77 7 167948 46 34788930
Peripheral arterial occlusive disease 16.41 12.77 4 167951 5870 34783106
Retching 16.35 12.77 6 167949 6755 34782221
CSF protein increased 16.32 12.77 20 167935 806 34788170
Pneumonia parainfluenzae viral 16.31 12.77 10 167945 152 34788824
Haematemesis 16.28 12.77 73 167882 27638 34761338
Suspected product quality issue 16.25 12.77 10 167945 153 34788823
Candida endophthalmitis 16.24 12.77 9 167946 112 34788864
T-lymphocyte count decreased 16.15 12.77 11 167944 202 34788774
Mononeuropathy multiplex 16.15 12.77 11 167944 202 34788774
Splenic lesion 16.11 12.77 12 167943 255 34788721
Blood iron decreased 16.11 12.77 3 167952 5310 34783666
Skin abrasion 16.10 12.77 7 167948 7112 34781864
Blood urine present 16.03 12.77 17 167938 10817 34778159
Viral vasculitis 16.03 12.77 8 167947 79 34788897
Neutrophil count abnormal 16.01 12.77 31 167924 1871 34787105
Campylobacter infection 15.99 12.77 21 167934 908 34788068
Kidney transplant rejection 15.99 12.77 8 167947 7489 34781487
Precursor T-lymphoblastic lymphoma/leukaemia 15.96 12.77 7 167948 50 34788926
Hepatic cancer 15.96 12.77 10 167945 8265 34780711
Foetal growth abnormality 15.96 12.77 6 167949 27 34788949
Splenic marginal zone lymphoma 15.96 12.77 6 167949 27 34788949
Haemolysis 15.88 12.77 79 167876 8015 34780961
Gastric ulcer 15.86 12.77 32 167923 15618 34773358
Gout 15.82 12.77 44 167911 19209 34769767
Pericarditis 15.82 12.77 103 167852 11542 34777434
COVID-19 15.77 12.77 486 167469 77064 34711912
Haemophilus infection 15.68 12.77 24 167931 1197 34787779
Phlebitis infective 15.64 12.77 9 167946 121 34788855
Cerebral salt-wasting syndrome 15.62 12.77 7 167948 53 34788923
Thinking abnormal 15.62 12.77 5 167950 6132 34782844
Ureteric compression 15.61 12.77 12 167943 268 34788708
Contraindicated product administered 15.57 12.77 52 167903 21429 34767547
Poor venous access 15.56 12.77 3 167952 5180 34783796
Pneumococcal infection 15.55 12.77 15 167940 459 34788517
Microangiopathy 15.55 12.77 21 167934 933 34788043
Cold sweat 15.55 12.77 15 167940 9972 34779004
Device occlusion 15.51 12.77 6 167949 6539 34782437
T-cell prolymphocytic leukaemia 15.51 12.77 7 167948 54 34788922
Vascular access complication 15.50 12.77 13 167942 330 34788646
Refractory cytopenia with unilineage dysplasia 15.48 12.77 16 167939 533 34788443
Hypokinesia 15.45 12.77 12 167943 8868 34780108
Urinary bladder rupture 15.45 12.77 8 167947 86 34788890
Feeling cold 15.41 12.77 17 167938 10622 34778354
Central nervous system mass 15.39 12.77 10 167945 169 34788807
Cytokine storm 15.35 12.77 18 167937 692 34788284
Blood bilirubin increased 15.33 12.77 264 167691 38032 34750944
Immunodeficiency common variable 15.29 12.77 10 167945 171 34788805
Light chain disease 15.26 12.77 9 167946 127 34788849
Hepatic cytolysis 15.24 12.77 29 167926 14467 34774509
Benign prostatic hyperplasia 15.24 12.77 29 167926 14466 34774510
Citrobacter sepsis 15.18 12.77 7 167948 57 34788919
Peroneal nerve palsy 15.15 12.77 40 167915 2971 34786005
Herpes zoster infection neurological 15.15 12.77 4 167951 3 34788973
Left ventricular dysfunction 15.14 12.77 91 167864 9916 34779060
Hepatitis B DNA increased 15.10 12.77 16 167939 549 34788427
Hiatus hernia 15.08 12.77 9 167946 7636 34781340
Leukaemic infiltration 15.08 12.77 9 167946 130 34788846
Bacillus infection 15.05 12.77 12 167943 283 34788693
Dysstasia 15.05 12.77 22 167933 12173 34776803
Keratopathy 15.04 12.77 17 167938 628 34788348
Intussusception 15.01 12.77 17 167938 629 34788347
Tachycardia 15.00 12.77 302 167653 84470 34704506
Lung adenocarcinoma 14.99 12.77 53 167902 4618 34784358
BK polyomavirus test positive 14.99 12.77 6 167949 33 34788943
Anaphylactic shock 14.98 12.77 34 167921 15907 34773069
Infusion site discolouration 14.96 12.77 9 167946 132 34788844
Pulmonary hypoplasia 14.95 12.77 15 167940 482 34788494
Arteriosclerosis coronary artery 14.94 12.77 23 167932 12462 34776514
Throat tightness 14.92 12.77 11 167944 8347 34780629
Blood glucose abnormal 14.88 12.77 5 167950 5947 34783029
Kidney fibrosis 14.86 12.77 33 167922 2195 34786781
Gallbladder adenocarcinoma 14.86 12.77 5 167950 15 34788961
Malassezia infection 14.84 12.77 6 167949 34 34788942
Blast cells present 14.80 12.77 15 167940 488 34788488
Myeloproliferative neoplasm 14.80 12.77 16 167939 562 34788414
Herpes zoster reactivation 14.77 12.77 12 167943 291 34788685
Metastases to muscle 14.76 12.77 11 167944 234 34788742
Streptococcal bacteraemia 14.76 12.77 31 167924 1984 34786992
Acute hepatitis B 14.76 12.77 10 167945 182 34788794
Schizophrenia 14.71 12.77 12 167943 8654 34780322
Cytomegalovirus enteritis 14.70 12.77 15 167940 492 34788484
Diffuse large B-cell lymphoma stage II 14.70 12.77 6 167949 35 34788941
Influenza 14.69 12.77 160 167795 49506 34739470
Central nervous system vasculitis 14.65 12.77 15 167940 494 34788482
Precursor T-lymphoblastic lymphoma/leukaemia recurrent 14.62 12.77 5 167950 16 34788960
Cryptococcal fungaemia 14.61 12.77 8 167947 97 34788879
Desmoid tumour 14.61 12.77 8 167947 97 34788879
Drug clearance decreased 14.54 12.77 29 167926 1789 34787187
Bacterial disease carrier 14.53 12.77 15 167940 499 34788477
Crying 14.52 12.77 5 167950 5857 34783119
Sinus bradycardia 14.47 12.77 25 167930 12938 34776038
Kidney infection 14.44 12.77 4 167951 5390 34783586
Palatal ulcer 14.42 12.77 6 167949 37 34788939
Intraocular pressure increased 14.40 12.77 4 167951 5379 34783597
Skin mass 14.36 12.77 47 167908 3938 34785038
Morganella infection 14.34 12.77 15 167940 507 34788469
Combined immunodeficiency 14.31 12.77 7 167948 66 34788910
Enterobacter bacteraemia 14.26 12.77 14 167941 438 34788538
Vomiting 14.25 12.77 1011 166944 246610 34542366
Autoimmune pancytopenia 14.20 12.77 8 167947 103 34788873
Peritoneal lesion 14.13 12.77 8 167947 104 34788872
Disease susceptibility 14.13 12.77 7 167948 68 34788908
Morphoea 14.12 12.77 10 167945 196 34788780
Pneumonia necrotising 14.11 12.77 18 167937 756 34788220
Femur fracture 14.10 12.77 11 167944 8113 34780863
Abdominal wall abscess 14.08 12.77 15 167940 518 34788458
Chronic graft versus host disease in intestine 14.07 12.77 11 167944 252 34788724
Blood pressure abnormal 14.04 12.77 11 167944 8095 34780881
Dizziness postural 14.04 12.77 6 167949 6158 34782818
Cutaneous T-cell lymphoma recurrent 14.03 12.77 6 167949 40 34788936
Blood pressure diastolic abnormal 14.02 12.77 3 167952 4815 34784161
Mania 13.99 12.77 15 167940 9496 34779480
Glottis carcinoma 13.96 12.77 5 167950 19 34788957
Follicular mucinosis 13.96 12.77 5 167950 19 34788957
Autonomic neuropathy 13.95 12.77 20 167935 940 34788036
Blood potassium decreased 13.94 12.77 42 167913 17873 34771103
Respiratory tract congestion 13.94 12.77 6 167949 6133 34782843
POEMS syndrome 13.91 12.77 6 167949 41 34788935
Tongue fungal infection 13.91 12.77 6 167949 41 34788935
Impaired work ability 13.89 12.77 8 167947 6922 34782054
Upper limb fracture 13.80 12.77 3 167952 4763 34784213
Blastic plasmacytoid dendritic cell neoplasia 13.78 12.77 7 167948 72 34788904
Sinusitis bacterial 13.75 12.77 14 167941 458 34788518
Sleep disorder due to a general medical condition 13.74 12.77 4 167951 5217 34783759
Endocarditis bacterial 13.72 12.77 20 167935 955 34788021
Superior sagittal sinus thrombosis 13.67 12.77 11 167944 263 34788713
Post procedural complication 13.61 12.77 21 167934 11367 34777609
Lung opacity 13.60 12.77 33 167922 2326 34786650
Myositis 13.59 12.77 102 167853 11968 34777008
Pneumonia measles 13.57 12.77 5 167950 21 34788955
Cerebrosclerosis 13.57 12.77 5 167950 21 34788955
Coxsackie viral infection 13.57 12.77 5 167950 21 34788955
Gastric stenosis 13.54 12.77 7 167948 75 34788901
Post lumbar puncture syndrome 13.53 12.77 10 167945 210 34788766
Fungal test positive 13.51 12.77 15 167940 543 34788433
Ankylosing spondylitis 13.51 12.77 5 167950 5599 34783377
Gastrointestinal obstruction 13.50 12.77 19 167936 878 34788098
Metapneumovirus infection 13.48 12.77 18 167937 791 34788185
Cerebral infarction 13.47 12.77 77 167878 27378 34761598
Chromosome analysis abnormal 13.46 12.77 9 167946 160 34788816
Umbilical hernia 13.43 12.77 3 167952 4674 34784302
Personality change 13.41 12.77 4 167951 5135 34783841
Granulocytopenia neonatal 13.39 12.77 5 167950 22 34788954
Fusobacterium infection 13.38 12.77 7 167948 77 34788899
Atypical teratoid/rhabdoid tumour of CNS 13.36 12.77 4 167951 7 34788969
Mental impairment 13.35 12.77 18 167937 10304 34778672
Aortic arteriosclerosis 13.26 12.77 3 167952 4633 34784343
Tooth hypoplasia 13.26 12.77 8 167947 118 34788858
Cancer fatigue 13.22 12.77 7 167948 79 34788897
Speech disorder 13.17 12.77 71 167884 25615 34763361
Gastritis erosive 13.15 12.77 6 167949 5926 34783050
Throat irritation 13.15 12.77 19 167936 10566 34778410
Complications of transplanted kidney 13.15 12.77 3 167952 4606 34784370
Premature ageing 13.15 12.77 7 167948 80 34788896
Renal amyloidosis 13.15 12.77 7 167948 80 34788896
Hepatitis 13.15 12.77 174 167781 23730 34765246
Pancreatic carcinoma 13.14 12.77 14 167941 8887 34780089
Prostatitis 13.13 12.77 5 167950 5502 34783474
Hepatitis B e antigen positive 13.11 12.77 6 167949 48 34788928
Emphysematous cholecystitis 13.11 12.77 6 167949 48 34788928
Vascular injury 13.09 12.77 11 167944 280 34788696
Meningitis enterococcal 13.07 12.77 7 167948 81 34788895
Cerebral fungal infection 13.06 12.77 11 167944 281 34788695
VIth nerve paralysis 13.05 12.77 18 167937 816 34788160
Obstructive airways disorder 13.03 12.77 35 167920 15459 34773517
Transaminases increased 13.03 12.77 191 167764 26632 34762344
Disseminated large cell lymphoma 13.03 12.77 3 167952 0 34788976
Klippel-Feil syndrome 13.03 12.77 3 167952 0 34788976
Retrograde portal vein flow 13.03 12.77 3 167952 0 34788976
Hepatosplenic abscess 13.03 12.77 3 167952 0 34788976
Ganglioneuroma 13.02 12.77 4 167951 8 34788968
Hypoglobulinaemia 13.02 12.77 4 167951 8 34788968
Lymphoplasmacytoid lymphoma/immunocytoma recurrent 13.02 12.77 4 167951 8 34788968
CD4 lymphocytes decreased 13.00 12.77 27 167928 1714 34787262
Autologous haematopoietic stem cell transplant 13 12.77 6 167949 49 34788927
Choking 12.91 12.77 4 167951 5011 34783965
Tracheal fistula 12.91 12.77 8 167947 124 34788852
Viral skin infection 12.90 12.77 6 167949 50 34788926
Urinary bladder toxicity 12.88 12.77 5 167950 25 34788951
Wall motion score index abnormal 12.86 12.77 9 167946 173 34788803
Foot deformity 12.85 12.77 3 167952 4534 34784442
Tendon rupture 12.81 12.77 9 167946 7003 34781973
Bladder hypertrophy 12.78 12.77 16 167939 659 34788317

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 9588.83 11.09 7748 317613 223251 79195776
Neutropenia 3840.91 11.09 5268 320093 282442 79136585
Myelosuppression 3032.20 11.09 1946 323415 38350 79380677
Cytokine release syndrome 2625.84 11.09 1705 323656 34293 79384734
Product use in unapproved indication 2109.04 11.09 3711 321650 246648 79172379
Bone marrow failure 2037.21 11.09 1680 323681 49427 79369600
Disease progression 1914.25 11.09 3003 322358 181359 79237668
Acute myeloid leukaemia 1778.36 11.09 1264 324097 29621 79389406
Cytomegalovirus infection 1752.29 11.09 1427 323934 41217 79377810
Mucosal inflammation 1655.68 11.09 1782 323579 73798 79345229
Myelodysplastic syndrome 1655.03 11.09 1201 324160 29100 79389927
Pancytopenia 1605.09 11.09 2616 322745 163129 79255898
Haematotoxicity 1497.65 11.09 879 324482 14640 79404387
Acute graft versus host disease 1437.35 11.09 741 324620 9426 79409601
Hypogammaglobulinaemia 1266.70 11.09 740 324621 12211 79406816
Off label use 1258.10 11.09 7121 318240 900094 78518933
Cystitis haemorrhagic 1252.14 11.09 653 324708 8519 79410508
White blood cell count decreased 1215.66 11.09 2494 322867 185794 79233233
Venoocclusive liver disease 1205.48 11.09 693 324668 11078 79407949
Second primary malignancy 1188.88 11.09 737 324624 13613 79405414
Thrombocytopenia 1178.56 11.09 3031 322330 262228 79156799
Pyrexia 1150.33 11.09 5635 319726 673074 78745953
Agranulocytosis 1133.35 11.09 1144 324217 43886 79375141
Neutrophil count decreased 1122.23 11.09 1635 323726 92324 79326703
Cytopenia 1085.94 11.09 796 324565 19587 79399440
Diffuse large B-cell lymphoma recurrent 1073.41 11.09 461 324900 3746 79415281
Pneumocystis jirovecii pneumonia 1067.91 11.09 957 324404 31551 79387476
Graft versus host disease 1032.59 11.09 686 324675 14340 79404687
Leukopenia 1012.51 11.09 1753 323608 114760 79304267
Chronic graft versus host disease 989.70 11.09 505 324856 6276 79412751
Progressive multifocal leukoencephalopathy 989.40 11.09 756 324605 19844 79399183
Hepatitis B 984.92 11.09 539 324822 7793 79411234
Completed suicide 898.20 11.09 22 325339 245745 79173282
Fall 895.42 11.09 436 324925 487193 78931834
Arthralgia 870.91 11.09 639 324722 571164 78847863
Pain 868.66 11.09 957 324404 702845 78716182
Hepatitis B reactivation 857.08 11.09 443 324918 5665 79413362
Sepsis 856.72 11.09 2730 322631 266698 79152329
Acute graft versus host disease in skin 846.52 11.09 474 324887 7184 79411843
Neurotoxicity 827.08 11.09 831 324530 31687 79387340
Malignant neoplasm progression 776.13 11.09 1714 323647 134276 79284751
Posterior reversible encephalopathy syndrome 768.45 11.09 725 324636 25556 79393471
Febrile bone marrow aplasia 763.41 11.09 539 324822 12481 79406546
Cytomegalovirus infection reactivation 755.98 11.09 461 324900 8255 79410772
Septic shock 746.70 11.09 1588 323773 121213 79297814
Tumour lysis syndrome 724.16 11.09 673 324688 23266 79395761
Neutropenic sepsis 724.12 11.09 711 324650 26353 79392674
Haemophagocytic lymphohistiocytosis 717.41 11.09 643 324718 21194 79397833
Therapy partial responder 684.64 11.09 568 324793 16829 79402198
Joint swelling 684.11 11.09 168 325193 288478 79130549
Cardiotoxicity 676.95 11.09 489 324872 11750 79407277
Immune effector cell-associated neurotoxicity syndrome 662.84 11.09 368 324993 5480 79413547
Product dose omission issue 655.10 11.09 111 325250 247426 79171601
Neoplasm progression 629.32 11.09 908 324453 50774 79368253
Venoocclusive disease 608.25 11.09 320 325041 4253 79414774
Platelet count decreased 607.74 11.09 1961 323400 192703 79226324
Epstein-Barr virus infection 601.53 11.09 487 324874 13929 79405098
Multiple organ dysfunction syndrome 593.90 11.09 1432 323929 118814 79300213
Pruritus 589.85 11.09 449 324912 394199 79024828
BK virus infection 566.68 11.09 386 324975 8418 79410609
Synovitis 564.38 11.09 10 325351 150724 79268303
Dizziness 558.62 11.09 802 324559 525639 78893388
Rheumatoid arthritis 539.51 11.09 99 325262 208371 79210656
Drug abuse 532.35 11.09 33 325328 162658 79256369
Abdominal discomfort 527.85 11.09 182 325179 250545 79168482
Interstitial lung disease 524.24 11.09 1311 324050 111289 79307738
Disease recurrence 519.63 11.09 763 324598 43346 79375681
Graft versus host disease in skin 515.92 11.09 317 325044 5756 79413271
Peripheral swelling 509.69 11.09 231 325130 269386 79149641
Arthropathy 501.74 11.09 65 325296 177046 79241981
Adenovirus infection 495.92 11.09 350 325011 8097 79410930
Respiratory failure 494.35 11.09 1743 323618 179168 79239859
Drug hypersensitivity 493.16 11.09 305 325056 298611 79120416
Neuropathy peripheral 493.09 11.09 1480 323881 139825 79279202
Bronchopulmonary aspergillosis 490.07 11.09 527 324834 21767 79397260
Aspergillus infection 480.46 11.09 486 324875 18675 79400352
Acute lymphocytic leukaemia recurrent 477.99 11.09 276 325085 4448 79414579
Swelling 465.38 11.09 152 325209 216559 79202468
Nasopharyngitis 463.75 11.09 228 325133 253653 79165374
Weight increased 460.38 11.09 281 325080 277105 79141922
Fatigue 459.03 11.09 2095 323266 927632 78491395
Post transplant lymphoproliferative disorder 454.63 11.09 376 324985 11088 79407939
Anxiety 452.67 11.09 224 325137 248288 79170739
Overdose 452.55 11.09 99 325262 184107 79234920
Diffuse large B-cell lymphoma 451.90 11.09 384 324977 11765 79407262
Rash 445.26 11.09 1071 324290 577287 78841740
Headache 443.21 11.09 1290 324071 652482 78766545
Cytomegalovirus viraemia 422.04 11.09 378 324983 12443 79406584
Pain in extremity 414.97 11.09 527 324834 364011 79055016
Thrombotic microangiopathy 412.44 11.09 459 324902 19710 79399317
Premature menopause 412.02 11.09 137 325224 485 79418542
Lymphopenia 410.74 11.09 563 324798 29994 79389033
Intentional overdose 405.30 11.09 5 325356 105955 79313072
Cytomegalovirus chorioretinitis 404.83 11.09 262 325099 5228 79413799
Malaise 401.21 11.09 877 324484 488992 78930035
Drug interaction 396.73 11.09 678 324683 414505 79004522
Graft versus host disease in gastrointestinal tract 395.66 11.09 273 325088 6083 79412944
Blood pressure increased 390.22 11.09 187 325174 211173 79207854
Therapeutic product effect decreased 380.98 11.09 99 325262 163764 79255263
Pemphigus 379.56 11.09 5 325356 99577 79319450
Musculoskeletal stiffness 377.02 11.09 122 325239 174886 79244141
Cardiomyopathy 365.60 11.09 516 324845 28258 79390769
Glossodynia 363.65 11.09 13 325348 103324 79315703
Contraindicated product administered 360.90 11.09 98 325263 157440 79261587
Injection site pain 359.73 11.09 51 325310 129787 79289240
Wound 350.73 11.09 34 325327 116145 79302882
Ejection fraction decreased 343.77 11.09 553 324808 34024 79385003
Aplasia 342.89 11.09 272 325089 7548 79411479
Contusion 341.84 11.09 92 325269 148684 79270343
Human herpesvirus 6 infection 330.39 11.09 229 325132 5141 79413886
Feeling abnormal 325.63 11.09 121 325240 159078 79259949
Stem cell transplant 316.32 11.09 194 325167 3510 79415517
Systemic lupus erythematosus 312.31 11.09 58 325303 121091 79297936
Insomnia 310.63 11.09 325 325036 244845 79174182
Lymphadenopathy 310.07 11.09 677 324684 52570 79366457
Inappropriate schedule of product administration 302.56 11.09 85 325276 133543 79285484
Anaemia 298.46 11.09 2948 322413 442067 78976960
Hypersensitivity 295.24 11.09 382 324979 261857 79157170
Muscle spasms 293.96 11.09 174 325187 174556 79244471
Bacteraemia 282.32 11.09 492 324869 32332 79386695
Psoriatic arthropathy 280.92 11.09 8 325353 77991 79341036
Intentional product misuse 274.12 11.09 33 325328 95132 79323895
Somnolence 273.27 11.09 344 325017 238637 79180390
Diffuse large B-cell lymphoma refractory 272.73 11.09 128 325233 1307 79417720
Urticaria 270.84 11.09 215 325146 184986 79234041
Depression 267.22 11.09 294 325067 216496 79202531
Lymphocyte count decreased 263.77 11.09 591 324770 46698 79372329
Polyneuropathy 261.90 11.09 402 324959 23749 79395278
Acute graft versus host disease in intestine 259.65 11.09 177 325184 3864 79415163
Blood lactate dehydrogenase increased 257.07 11.09 523 324838 38647 79380380
Mobility decreased 256.40 11.09 89 325272 122086 79296941
Acute promyelocytic leukaemia 255.93 11.09 124 325237 1367 79417660
Myocardial infarction 255.41 11.09 225 325136 183904 79235123
Dyspnoea 255.34 11.09 2254 323107 854771 78564256
Viral haemorrhagic cystitis 253.76 11.09 137 325224 1924 79417103
Psoriasis 253.33 11.09 33 325328 89554 79329473
Loss of personal independence in daily activities 248.09 11.09 57 325304 102523 79316504
B-cell lymphoma recurrent 246.64 11.09 107 325254 893 79418134
Hepatic enzyme increased 246.31 11.09 229 325132 182381 79236646
Gait disturbance 243.21 11.09 293 325068 207213 79211814
Suicide attempt 240.74 11.09 28 325333 82904 79336123
Epstein-Barr virus associated lymphoproliferative disorder 239.60 11.09 160 325201 3372 79415655
Metastases to bone 239.16 11.09 388 324973 24039 79394988
Secondary immunodeficiency 237.62 11.09 154 325207 3080 79415947
Neutropenic colitis 236.39 11.09 192 325169 5515 79413512
Drug resistance 235.92 11.09 528 324833 41685 79377342
Discomfort 235.04 11.09 109 325252 125508 79293519
Fibromyalgia 233.94 11.09 6 325355 64334 79354693
Asthma 232.23 11.09 131 325230 134964 79284063
JC virus infection 230.58 11.09 162 325199 3719 79415308
Injury 230.44 11.09 24 325337 77472 79341555
Ovarian failure 229.94 11.09 91 325270 585 79418442
Cytogenetic abnormality 228.26 11.09 105 325256 1020 79418007
Duodenal ulcer perforation 227.28 11.09 10 325351 66201 79352826
Acute lymphocytic leukaemia 226.84 11.09 177 325184 4792 79414235
Herpes simplex 223.20 11.09 262 325099 11925 79407102
Wheezing 221.76 11.09 99 325262 116565 79302462
Plasma cell myeloma recurrent 221.52 11.09 175 325186 4826 79414201
Blood cholesterol increased 220.28 11.09 38 325323 83682 79335345
Pleural effusion 219.60 11.09 1171 324190 144091 79274936
Irritable bowel syndrome 218.38 11.09 8 325353 62233 79356794
Osteoarthritis 218.27 11.09 45 325316 87264 79331763
Stress 216.49 11.09 33 325328 79579 79339448
Injection site erythema 209.05 11.09 34 325327 78163 79340864
Arthritis 208.34 11.09 104 325257 114776 79304251
Staphylococcal bacteraemia 206.26 11.09 252 325109 11966 79407061
Bacterial infection 204.48 11.09 417 324944 30863 79388164
Neoplasm recurrence 203.05 11.09 155 325206 4059 79414968
B-cell type acute leukaemia 202.00 11.09 78 325283 465 79418562
Abdominal pain upper 201.34 11.09 379 324982 223440 79195587
Acquired gene mutation 201.08 11.09 121 325240 2112 79416915
Pneumonia fungal 200.34 11.09 238 325123 10972 79408055
Helicobacter infection 198.71 11.09 25 325336 69679 79349348
Left ventricular dysfunction 195.65 11.09 312 325049 19049 79399978
Hospitalisation 193.70 11.09 71 325290 94165 79324862
Systemic mycosis 193.55 11.09 126 325235 2540 79416487
Hypoglycaemia 193.42 11.09 86 325275 101508 79317519
Chronic lymphocytic leukaemia recurrent 192.03 11.09 79 325282 569 79418458
Heart rate decreased 191.53 11.09 29 325332 70287 79348740
Osteonecrosis 190.92 11.09 404 324957 30691 79388336
Rhabdomyolysis 190.60 11.09 91 325270 103040 79315987
Mucormycosis 189.28 11.09 202 325159 8267 79410760
Weight decreased 188.58 11.09 777 324584 354421 79064606
Metastases to lymph nodes 187.89 11.09 222 325139 10175 79408852
Cardiac failure 186.32 11.09 1175 324186 153667 79265360
Hepatic failure 183.79 11.09 609 324752 60603 79358424
Klebsiella infection 183.74 11.09 271 325090 15449 79403578
Candida infection 181.96 11.09 449 324912 37765 79381262
Chronic graft versus host disease in skin 180.98 11.09 100 325261 1474 79417553
Infusion related reaction 180.90 11.09 421 324940 229816 79189211
Confusional state 179.36 11.09 679 324682 317318 79101709
Toxicity to various agents 178.44 11.09 1000 324361 420540 78998487
Bronchitis 178.31 11.09 162 325199 130482 79288545
Blister 178.05 11.09 136 325225 119340 79299687
Enterococcal infection 177.35 11.09 266 325095 15394 79403633
Clostridium difficile colitis 177.27 11.09 401 324960 31882 79387145
Bacterial sepsis 177.01 11.09 192 325169 8006 79411021
Drug intolerance 177.00 11.09 523 324838 263596 79155431
Drug ineffective for unapproved indication 175.07 11.09 533 324828 50705 79368322
Incorrect dose administered 174.82 11.09 48 325313 76582 79342445
Pseudomonal sepsis 174.11 11.09 167 325194 6007 79413020
Metastases to liver 173.99 11.09 368 324993 27946 79391081
Leukoencephalopathy 173.47 11.09 187 325174 7742 79411285
Blood glucose increased 172.45 11.09 130 325231 114845 79304182
Acute graft versus host disease in liver 172.04 11.09 104 325257 1831 79417196
Congestive cardiomyopathy 171.97 11.09 226 325135 11554 79407473
Parainfluenzae virus infection 170.36 11.09 159 325202 5523 79413504
Engraftment syndrome 168.86 11.09 92 325269 1317 79417710
Pneumonia cytomegaloviral 168.50 11.09 149 325212 4820 79414207
Leukaemia recurrent 167.62 11.09 117 325244 2657 79416370
Sinusitis 167.20 11.09 341 325020 195160 79223867
Pneumonia 167.11 11.09 3692 321669 656554 78762473
Migraine 166.65 11.09 74 325287 87419 79331608
Suicidal ideation 166.49 11.09 52 325309 76288 79342739
Lymphoma 166.41 11.09 274 325087 17186 79401841
Central nervous system lymphoma 165.73 11.09 108 325253 2181 79416846
Pseudomonas infection 165.21 11.09 302 325059 20601 79398426
Cardiac dysfunction 162.96 11.09 135 325226 3989 79415038
International normalised ratio increased 159.26 11.09 73 325288 84648 79334379
Rhinovirus infection 159.17 11.09 179 325182 7774 79411253
C-reactive protein abnormal 157.57 11.09 10 325351 48357 79370670
Cystitis viral 157.33 11.09 71 325290 657 79418370
Varicella zoster virus infection 154.26 11.09 135 325226 4306 79414721
Serotonin syndrome 153.89 11.09 7 325354 45020 79374007
Metastases to lung 151.96 11.09 269 325092 17894 79401133
Sedation 151.92 11.09 17 325344 51878 79367149
Bradycardia 151.88 11.09 198 325163 135359 79283668
Sleep disorder 151.71 11.09 80 325281 85597 79333430
Hyperhidrosis 151.27 11.09 240 325121 151252 79267775
Mantle cell lymphoma recurrent 150.08 11.09 65 325296 540 79418487
Injection site swelling 149.88 11.09 11 325350 47121 79371906
Injection site bruising 148.40 11.09 4 325357 40998 79378029
Injection site pruritus 146.41 11.09 6 325355 42277 79376750
Aplastic anaemia 145.72 11.09 262 325099 17643 79401384
Plasmacytoma 145.27 11.09 130 325231 4273 79414754
Loss of consciousness 145.24 11.09 291 325070 167652 79251375
Chest pain 145.15 11.09 625 324736 281679 79137348
Impaired healing 144.96 11.09 89 325272 87566 79331461
Blood pressure fluctuation 144.18 11.09 47 325314 67098 79351929
Blood pressure systolic increased 143.64 11.09 47 325314 66939 79352088
Condition aggravated 141.74 11.09 1334 324027 499790 78919237
Refractory anaemia with an excess of blasts 139.58 11.09 70 325291 836 79418191
Cerebrovascular accident 138.69 11.09 264 325097 155028 79263999
Cytomegalovirus test positive 138.51 11.09 145 325216 5802 79413225
Hallucination 136.40 11.09 91 325270 85654 79333373
Musculoskeletal pain 134.86 11.09 131 325230 102223 79316804
Staphylococcal sepsis 134.86 11.09 227 325134 14499 79404528
Angioedema 134.62 11.09 71 325290 75964 79343063
Fusarium infection 134.02 11.09 87 325274 1745 79417282
Injection site reaction 133.33 11.09 30 325331 54755 79364272
Fungal infection 133.11 11.09 424 324937 41324 79377703
Disseminated intravascular coagulation 133.04 11.09 384 324977 35458 79383569
Peripheral sensory neuropathy 133.03 11.09 211 325150 12822 79406205
Chronic obstructive pulmonary disease 132.75 11.09 93 325268 85326 79333701
Pneumonitis 132.66 11.09 546 324815 60314 79358713
Aggression 132.15 11.09 24 325337 50934 79368093
Sweat gland tumour 131.87 11.09 57 325304 471 79418556
Organising pneumonia 131.35 11.09 191 325170 10748 79408279
Systemic candida 130.91 11.09 149 325212 6557 79412470
Coronary artery disease 130.11 11.09 52 325309 65422 79353605
Transplant failure 129.86 11.09 125 325236 4516 79414511
Multiple sclerosis relapse 129.50 11.09 18 325343 46515 79372512
Staphylococcal infection 129.45 11.09 526 324835 57769 79361258
Escherichia bacteraemia 128.44 11.09 146 325215 6416 79412611
Dyspepsia 126.70 11.09 154 325207 108533 79310494
Gastrooesophageal reflux disease 126.58 11.09 143 325218 104103 79314924
Myelopathy 126.28 11.09 123 325238 4510 79414517
Nephropathy toxic 126.17 11.09 266 325095 20153 79398874
Palpitations 126.00 11.09 201 325160 126409 79292618
Therapy non-responder 125.99 11.09 724 324637 91581 79327446
Hepatotoxicity 125.88 11.09 478 324883 50874 79368153
Folliculitis 125.74 11.09 35 325326 55345 79363682
Heart rate increased 125.57 11.09 186 325175 120538 79298489
Gene mutation 125.48 11.09 97 325264 2589 79416438
Acute respiratory distress syndrome 124.84 11.09 430 324931 43637 79375390
Balance disorder 124.01 11.09 132 325229 98725 79320302
Pericarditis 123.31 11.09 146 325215 104090 79314937
Computerised tomogram thorax abnormal 123.25 11.09 92 325269 2327 79416700
Blood follicle stimulating hormone increased 123.22 11.09 48 325313 294 79418733
Hypoxia 122.61 11.09 781 324580 102462 79316565
Infection reactivation 122.06 11.09 95 325266 2562 79416465
Dry mouth 121.45 11.09 108 325253 87911 79331116
Enterococcal bacteraemia 120.33 11.09 100 325261 2968 79416059
Medication error 120.19 11.09 65 325296 68577 79350450
Adverse drug reaction 119.01 11.09 61 325300 66331 79352696
Breast cancer recurrent 118.78 11.09 98 325263 2879 79416148
Metastases to central nervous system 118.72 11.09 228 325133 16147 79402880
Product prescribing error 118.62 11.09 20 325341 44793 79374234
Back pain 118.30 11.09 741 324620 303439 79115588
Type 2 diabetes mellitus 117.44 11.09 43 325318 57079 79361948
Nasal congestion 116.79 11.09 85 325276 76467 79342560
End stage renal disease 116.77 11.09 192 325169 12028 79406999
Hyperkalaemia 116.32 11.09 179 325182 114219 79304808
Capillary leak syndrome 116.08 11.09 109 325252 3816 79415211
Infection 115.23 11.09 1499 323862 240213 79178814
Escherichia sepsis 114.67 11.09 157 325204 8351 79410676
Prescribed overdose 114.53 11.09 11 325350 37872 79381155
Recurrent cancer 114.50 11.09 92 325269 2601 79416426
Myeloid leukaemia 114.01 11.09 57 325304 676 79418351
Graft versus host disease in liver 113.10 11.09 77 325284 1677 79417350
Refractory cytopenia with multilineage dysplasia 111.87 11.09 42 325319 229 79418798
Urinary tract infection 111.83 11.09 659 324702 273853 79145174
Alopecia 111.80 11.09 524 324837 230831 79188196
Pneumatosis intestinalis 111.33 11.09 134 325227 6263 79412764
Nocardiosis 110.56 11.09 126 325235 5553 79413474
Swollen tongue 110.49 11.09 20 325341 42550 79376477
Epstein-Barr virus infection reactivation 110.14 11.09 78 325283 1814 79417213
Acute myeloid leukaemia recurrent 109.87 11.09 99 325262 3284 79415743
Chronic myeloid leukaemia 108.83 11.09 102 325259 3562 79415465
Joint stiffness 108.57 11.09 18 325343 40812 79378215
Adverse event 108.42 11.09 55 325306 60159 79358868
Lung infiltration 107.79 11.09 268 325093 22644 79396383
Product quality issue 107.69 11.09 8 325353 33932 79385095
Emotional distress 107.67 11.09 17 325344 39952 79379075
Electrocardiogram QT prolonged 107.56 11.09 126 325235 90260 79328767
Viraemia 107.34 11.09 91 325270 2778 79416249
Metastasis 106.69 11.09 136 325225 6744 79412283
Accidental overdose 106.25 11.09 17 325344 39564 79379463
Neck pain 105.91 11.09 91 325270 75326 79343701
Strongyloidiasis 105.34 11.09 103 325258 3795 79415232
Drug withdrawal syndrome 105.17 11.09 10 325351 34708 79384319
Minimal residual disease 105 11.09 48 325313 459 79418568
Nephrolithiasis 104.79 11.09 43 325318 53248 79365779
Breast cancer metastatic 104.45 11.09 151 325210 8451 79410576
Intestinal perforation 104.19 11.09 224 325137 17202 79401825
Pulmonary alveolar haemorrhage 104.11 11.09 176 325185 11281 79407746
Gastrointestinal toxicity 103.85 11.09 146 325215 7963 79411064
Lactic acidosis 103.65 11.09 81 325280 70278 79348749
Escherichia infection 103.63 11.09 228 325133 17789 79401238
Memory impairment 103.25 11.09 186 325175 111548 79307479
Bone pain 103.09 11.09 476 324885 55266 79363761
Encephalitis 102.72 11.09 202 325159 14558 79404469
Illness 102.64 11.09 31 325330 46480 79372547
Blood stem cell transplant failure 102.53 11.09 48 325313 487 79418540
Road traffic accident 102.15 11.09 26 325335 43638 79375389
Acute myelomonocytic leukaemia 101.14 11.09 41 325320 283 79418744
Pulmonary haemorrhage 100.72 11.09 200 325161 14517 79404510
Oedema peripheral 100.45 11.09 610 324751 251678 79167349
Lymphoproliferative disorder 99.99 11.09 119 325242 5496 79413531
Cytokine increased 99.49 11.09 32 325329 99 79418928
Enterobacter infection 98.76 11.09 107 325254 4455 79414572
Oxygen saturation decreased 98.09 11.09 240 325121 128807 79290220
Myalgia 96.58 11.09 409 324952 185232 79233795
Frequent bowel movements 96.54 11.09 6 325355 29533 79389494
Injection site haemorrhage 96.34 11.09 4 325357 27866 79391161
Encephalopathy 96.16 11.09 535 324826 66862 79352165
Primary hypogonadism 95.86 11.09 34 325327 153 79418874
Skin toxicity 95.25 11.09 142 325219 8172 79410855
Epstein-Barr viraemia 95.18 11.09 76 325285 2129 79416898
Rash pruritic 95.14 11.09 91 325270 71538 79347489
Granulocyte count decreased 94.89 11.09 70 325291 1738 79417289
Agitation 94.84 11.09 163 325198 99552 79319475
Human polyomavirus infection 94.63 11.09 58 325303 1048 79417979
Respiratory syncytial virus infection 94.29 11.09 151 325210 9251 79409776
Unevaluable event 93.92 11.09 55 325306 55530 79363497
Burning sensation 93.55 11.09 62 325299 58570 79360457
Bursitis 92.69 11.09 17 325344 35827 79383200
Amnesia 92.37 11.09 73 325288 62984 79356043
Engraft failure 92.29 11.09 49 325312 664 79418363
Ovarian atrophy 92.23 11.09 28 325333 67 79418960
Abdominal pain 92.13 11.09 1081 324280 388488 79030539
Tremor 92.05 11.09 369 324992 169714 79249313
Pneumomediastinum 91.89 11.09 93 325268 3574 79415453
Diarrhoea 91.15 11.09 2818 322543 877671 78541356
Complications of bone marrow transplant 91.05 11.09 47 325314 599 79418428
Maternal exposure during pregnancy 90.21 11.09 272 325089 136266 79282761
Haematochezia 90.19 11.09 136 325225 87509 79331518
Blood creatine phosphokinase increased 90.09 11.09 82 325279 66008 79353019
Mycobacterium chelonae infection 90.04 11.09 77 325284 2379 79416648
Encephalitis cytomegalovirus 90.04 11.09 57 325304 1093 79417934
Labelled drug-drug interaction medication error 89.23 11.09 6 325355 27644 79391383
Pneumocystis jirovecii infection 88.73 11.09 82 325279 2812 79416215
Hypoaesthesia 88.53 11.09 403 324958 178949 79240078
Biopsy lung abnormal 87.85 11.09 31 325330 137 79418890
5q minus syndrome 87.78 11.09 36 325325 257 79418770
Gastrosplenic fistula 87.35 11.09 29 325332 102 79418925
Chronic graft versus host disease in liver 86.79 11.09 46 325315 621 79418406
Gait inability 86.56 11.09 68 325293 58849 79360178
Nausea 86.52 11.09 3117 322244 954079 78464948
Leukaemia cutis 85.61 11.09 32 325329 172 79418855
Anti-Muellerian hormone level decreased 85.56 11.09 27 325334 77 79418950
Chemotherapy 85.48 11.09 65 325296 1692 79417335
Colony stimulating factor therapy 85.21 11.09 42 325319 482 79418545
Respiratory arrest 85.09 11.09 66 325295 57484 79361543
Pericardial effusion 84.88 11.09 394 324967 45843 79373184
Drug reaction with eosinophilia and systemic symptoms 84.88 11.09 82 325279 64162 79354865
Encephalitis viral 84.80 11.09 76 325285 2503 79416524
Cerebral toxoplasmosis 84.46 11.09 73 325288 2289 79416738
Osteosarcoma 84.36 11.09 38 325323 350 79418677
Neutrophil count abnormal 83.96 11.09 87 325274 3439 79415588
Drug dependence 83.29 11.09 31 325330 40738 79378289
Autoimmune haemolytic anaemia 83.23 11.09 134 325227 8246 79410781
Colitis 83.01 11.09 548 324813 72759 79346268
Klebsiella sepsis 82.45 11.09 83 325278 3169 79415858
Plasma cell leukaemia 82.35 11.09 64 325297 1722 79417305
Nervousness 81.91 11.09 18 325343 33397 79385630
Nodular regenerative hyperplasia 81.29 11.09 57 325304 1304 79417723
Acute monocytic leukaemia 81.15 11.09 41 325320 498 79418529
Toxoplasmosis 79.95 11.09 75 325286 2622 79416405
B-cell aplasia 79.57 11.09 31 325330 190 79418837
Chest discomfort 79.52 11.09 292 325069 137752 79281275
Joint range of motion decreased 79.45 11.09 19 325342 33263 79385764
Metabolic acidosis 79.32 11.09 134 325227 82395 79336632
Hypertension 79.18 11.09 916 324445 330076 79088951
Device related infection 78.97 11.09 313 325048 33981 79385046
Chronic myelomonocytic leukaemia 78.17 11.09 47 325314 819 79418208
Withdrawal syndrome 78.09 11.09 9 325352 26845 79392182
Human herpesvirus 8 infection 77.34 11.09 53 325308 1167 79417860
Peripheral T-cell lymphoma unspecified 77.04 11.09 43 325318 647 79418380
Blood fibrinogen decreased 76.57 11.09 64 325297 1915 79417112
Fluid retention 76.10 11.09 104 325257 69705 79349322
Treatment noncompliance 75.94 11.09 61 325300 52207 79366820
White blood cell count abnormal 75.90 11.09 105 325256 5640 79413387
Splenomegaly 75.71 11.09 221 325140 20533 79398494
Brain abscess 75.64 11.09 97 325264 4839 79414188
Thymus hypoplasia 75.61 11.09 48 325313 925 79418102
Gastric disorder 75.57 11.09 29 325332 37404 79381623
Flatulence 75.46 11.09 40 325321 42684 79376343
Foot deformity 75.46 11.09 6 325355 24068 79394959
Primary amyloidosis 74.99 11.09 27 325334 128 79418899
Skin laceration 74.32 11.09 14 325347 28948 79390079
Myelitis 73.80 11.09 68 325293 2323 79416704
Palmar-plantar erythrodysaesthesia syndrome 73.57 11.09 299 325062 32835 79386192
Restlessness 73.05 11.09 50 325311 46442 79372585
Sopor 72.84 11.09 22 325339 32988 79386039
Alpha haemolytic streptococcal infection 72.61 11.09 67 325294 2293 79416734
Bone marrow transplant rejection 72.58 11.09 31 325330 248 79418779
Lymphoid tissue hypoplasia 72.57 11.09 46 325315 884 79418143
Dry skin 72.42 11.09 103 325258 67892 79351135
Limb injury 72.19 11.09 16 325345 29512 79389515
Erythema 72.05 11.09 574 324787 222716 79196311
Coma 72 11.09 193 325168 100456 79318571
Nightmare 71.97 11.09 10 325351 25851 79393176
Traumatic lung injury 71.86 11.09 67 325294 2324 79416703
Bone marrow disorder 71.66 11.09 78 325283 3265 79415762
Human bocavirus infection 71.33 11.09 42 325319 703 79418324
Lip swelling 71.24 11.09 39 325322 40872 79378155
Cardio-respiratory arrest 71.07 11.09 217 325144 108293 79310734
Microsporidia infection 70.97 11.09 46 325315 920 79418107
Eye pruritus 70.94 11.09 3 325358 20567 79398460
Obliterative bronchiolitis 70.82 11.09 74 325287 2954 79416073
Malignant transformation 70.41 11.09 50 325311 1168 79417859
Surgery 70.23 11.09 23 325338 32743 79386284
Product substitution issue 69.71 11.09 3 325358 20253 79398774
Pseudocirrhosis 69.51 11.09 40 325321 640 79418387
Adenovirus reactivation 68.73 11.09 33 325328 356 79418671
Smooth muscle cell neoplasm 68.70 11.09 45 325316 917 79418110
B precursor type acute leukaemia 68.69 11.09 34 325327 394 79418633
Vertigo 68.40 11.09 110 325251 68972 79350055
Colitis ulcerative 68.36 11.09 28 325333 34714 79384313
Sciatica 68.31 11.09 25 325336 33197 79385830
Exposure during pregnancy 67.85 11.09 200 325161 100932 79318095
COVID-19 pneumonia 67.80 11.09 265 325096 28584 79390443
Polyomavirus viraemia 67.70 11.09 56 325305 1651 79417376
Leukaemia 67.60 11.09 101 325260 5824 79413203
Lymphoma transformation 67.58 11.09 31 325330 299 79418728
Chloroma 67.47 11.09 41 325320 729 79418298
Therapy interrupted 67.17 11.09 22 325339 31319 79387708
Feeling hot 67.14 11.09 87 325274 59647 79359380
Human herpesvirus 6 encephalitis 66.97 11.09 39 325322 639 79418388
Blood luteinising hormone increased 66.89 11.09 27 325334 184 79418843
B-cell lymphoma 66.74 11.09 103 325258 6112 79412915
Procedural pain 66.47 11.09 8 325353 23076 79395951
Ileus paralytic 66.15 11.09 131 325230 9489 79409538
Dry eye 66.08 11.09 34 325327 36897 79382130
Peripheral motor neuropathy 66.05 11.09 75 325286 3292 79415735
Pulmonary toxicity 66.03 11.09 156 325205 12758 79406269
Acne 65.94 11.09 15 325346 27175 79391852
Hypoalbuminaemia 65.80 11.09 214 325147 21083 79397944
Cytomegalovirus colitis 65.49 11.09 88 325273 4597 79414430
Hip arthroplasty 65.36 11.09 32 325329 35724 79383303
Blood pressure diastolic decreased 65.13 11.09 21 325340 30195 79388832
Vision blurred 65.01 11.09 218 325143 105680 79313347
Foot fracture 64.84 11.09 7 325354 21974 79397053
Head injury 64.53 11.09 36 325325 37333 79381694
Ascites 64.45 11.09 528 324833 75034 79343993
Grip strength decreased 64.42 11.09 7 325354 21862 79397165
Klebsiella bacteraemia 64.12 11.09 70 325291 2940 79416087
Hyperpyrexia 64.07 11.09 100 325261 5992 79413035
Eczema 64.00 11.09 44 325317 40774 79378253
Therapy responder 63.96 11.09 33 325328 420 79418607
Panic attack 63.67 11.09 11 325350 24205 79394822
Meningitis cryptococcal 63.58 11.09 75 325286 3431 79415596
Paraparesis 63.48 11.09 78 325283 3725 79415302
Candida sepsis 63.46 11.09 64 325297 2449 79416578
Dyskinesia 62.89 11.09 54 325307 44719 79374308
Guillain-Barre syndrome 62.76 11.09 123 325238 8842 79410185
Fungaemia 62.30 11.09 85 325276 4506 79414521
Therapy cessation 62.28 11.09 38 325323 37524 79381503
Lower limb fracture 62.25 11.09 10 325351 23205 79395822
Anaplastic lymphoma kinase gene mutation 62.09 11.09 23 325338 120 79418907
Cardiomyopathy acute 61.97 11.09 29 325332 294 79418733
Flushing 61.83 11.09 171 325190 88097 79330930
Respiratory depression 61.72 11.09 18 325343 27612 79391415
Respiratory tract infection fungal 61.51 11.09 46 325315 1167 79417860
Femur fracture 61.49 11.09 41 325320 38611 79380416
Red blood cell sedimentation rate increased 61.44 11.09 58 325303 45884 79373143
Remission not achieved 61.25 11.09 31 325330 378 79418649
Focal nodular hyperplasia 61.17 11.09 38 325323 704 79418323
Graft versus host disease in lung 61.11 11.09 41 325320 871 79418156
Bone marrow infiltration 60.98 11.09 38 325323 708 79418319
Aortitis 60.94 11.09 50 325311 1457 79417570
Idiopathic pneumonia syndrome 60.77 11.09 35 325326 561 79418466
Metastases to skin 60.68 11.09 53 325308 1686 79417341
Injection site mass 60.65 11.09 6 325355 20178 79398849
Wrong technique in product usage process 60.47 11.09 132 325229 73743 79345284
Metastases to bone marrow 60.04 11.09 39 325322 783 79418244
Fear 60.02 11.09 9 325352 21977 79397050
Stomatitis 59.67 11.09 885 324476 145872 79273155
Hepatitis E 59.40 11.09 67 325294 2919 79416108
Adenoviral haemorrhagic cystitis 59.39 11.09 33 325328 492 79418535
Prescribed underdose 59.36 11.09 23 325338 29491 79389536
Hepatic function abnormal 59.24 11.09 505 324856 72602 79346425
Pulmonary veno-occlusive disease 59.06 11.09 51 325310 1597 79417430
Transient ischaemic attack 58.96 11.09 77 325284 52618 79366409
Hepatosplenomegaly 58.85 11.09 96 325265 5973 79413054
Blood glucose decreased 58.77 11.09 17 325344 26217 79392810
Diffuse alveolar damage 58.68 11.09 73 325288 3531 79415496
Rheumatoid nodule 58.66 11.09 3 325358 17435 79401592
Hip fracture 58.59 11.09 26 325335 30735 79388292
Ocular hyperaemia 58.37 11.09 21 325340 28185 79390842
Clostridium difficile infection 58.35 11.09 335 325026 42350 79376677
Central nervous system fungal infection 57.82 11.09 31 325330 429 79418598
Venous thrombosis 57.74 11.09 104 325257 7012 79412015
Polyomavirus-associated nephropathy 57.29 11.09 91 325270 5536 79413491
Vasogenic cerebral oedema 57.18 11.09 48 325313 1445 79417582
Cholelithiasis 56.85 11.09 79 325282 52585 79366442
Rectal haemorrhage 56.33 11.09 144 325217 76156 79342871
Granulocytopenia 56.20 11.09 136 325225 11295 79407732
Depressed mood 56.16 11.09 69 325292 48411 79370616
Tendonitis 56.11 11.09 14 325347 23816 79395211
Alopecia areata 56.08 11.09 52 325309 1791 79417236
Swelling face 56.04 11.09 130 325231 71082 79347945
Eye swelling 55.99 11.09 19 325342 26449 79392578
Refractory cytopenia with unilineage dysplasia 55.86 11.09 39 325322 886 79418141
Adenoviral hepatitis 55.78 11.09 39 325322 888 79418139
Enterococcal sepsis 55.65 11.09 62 325299 2664 79416363
Nervous system disorder 55.44 11.09 237 325124 26619 79392408
Kidney infection 55.15 11.09 11 325350 21840 79397187
Multiple sclerosis 54.62 11.09 12 325349 22270 79396757
Oesophageal candidiasis 54.54 11.09 118 325243 9100 79409927
Blood pressure diastolic abnormal 54.45 11.09 7 325354 19195 79399832
Throat irritation 54.39 11.09 52 325309 40894 79378133
Alveolar soft part sarcoma 54.39 11.09 19 325342 81 79418946
Influenza like illness 53.97 11.09 134 325227 71573 79347454
Poisoning 53.70 11.09 18 325343 25254 79393773
Myeloproliferative neoplasm 53.51 11.09 39 325322 950 79418077
Delirium 53.47 11.09 172 325189 84455 79334572
Exostosis 53.41 11.09 4 325357 16854 79402173
Device issue 53.09 11.09 22 325339 27086 79391941
Abortion spontaneous 53.04 11.09 27 325334 29480 79389547
Device related thrombosis 53.03 11.09 60 325301 2623 79416404
Hot flush 52.82 11.09 89 325272 54788 79364239
Neutropenic infection 52.67 11.09 57 325304 2370 79416657
Cystitis bacterial 52.63 11.09 34 325327 676 79418351
Abdominal distension 52.60 11.09 280 325081 119370 79299657
Sleep apnoea syndrome 52.46 11.09 43 325318 36435 79382592
Epstein-Barr virus associated lymphoma 52.35 11.09 40 325321 1049 79417978
Lupus nephritis 52.33 11.09 63 325298 2945 79416082
Injection site rash 52.25 11.09 6 325355 17948 79401079
B-lymphocyte count abnormal 52.23 11.09 18 325343 73 79418954
Multifocal micronodular pneumocyte hyperplasia 52.23 11.09 18 325343 73 79418954
Herpes virus infection 52.14 11.09 99 325262 6950 79412077
Bronchial polyp 51.85 11.09 18 325343 75 79418952
Alveolar proteinosis 51.74 11.09 35 325326 754 79418273
Drug effective for unapproved indication 51.65 11.09 90 325271 5911 79413116
Orthostatic hypotension 51.42 11.09 94 325267 56070 79362957
Device dislocation 50.98 11.09 21 325340 25949 79393078
Limb discomfort 50.72 11.09 36 325325 32814 79386213
Pneumonia klebsiella 50.45 11.09 81 325280 4973 79414054
Blood calcium decreased 50.28 11.09 34 325327 31785 79387242
Ear infection 50.25 11.09 40 325321 34392 79384635
Sinus congestion 50.24 11.09 10 325351 19886 79399141
Computerised tomogram thorax 50.13 11.09 28 325333 422 79418605
Autoimmune neutropenia 50.10 11.09 31 325330 570 79418457
Myelitis transverse 49.93 11.09 50 325311 1897 79417130
Hepatomegaly 49.85 11.09 180 325181 18694 79400333
Hypersomnia 49.84 11.09 16 325345 23070 79395957
Norovirus test positive 49.81 11.09 32 325329 630 79418397
Influenza 49.66 11.09 317 325044 129289 79289738
Glioma 49.12 11.09 31 325330 591 79418436
Drug ineffective 49.03 11.09 5079 320282 1075834 78343193
Movement disorder 48.91 11.09 25 325336 27234 79391793
Hernia 48.90 11.09 6 325355 17053 79401974
Body temperature decreased 48.63 11.09 36 325325 32109 79386918
Aphasia 48.53 11.09 342 325019 46390 79372637
Visual impairment 48.49 11.09 202 325159 91929 79327098
Injection site warmth 48.41 11.09 3 325358 14804 79404223
Respiratory tract congestion 48.40 11.09 11 325350 19943 79399084
Syncope 48.34 11.09 483 324878 178966 79240061
Respiratory distress 48.33 11.09 405 324956 57934 79361093
Lower respiratory tract infection fungal 48.01 11.09 35 325326 853 79418174
Acute hepatitis B 47.96 11.09 28 325333 461 79418566
Skin discolouration 47.96 11.09 58 325303 40976 79378051
Hypertriglyceridaemia 47.76 11.09 137 325224 12603 79406424
Middle insomnia 47.70 11.09 5 325356 16064 79402963
Cerebral aspergillosis 47.68 11.09 47 325314 1749 79417278
Cutaneous calcification 47.64 11.09 19 325342 125 79418902
Metastases to pleura 47.58 11.09 44 325317 1510 79417517
Acute leukaemia 47.37 11.09 46 325315 1680 79417347
Liver function test abnormal 47.35 11.09 122 325239 64353 79354674
Alveolitis 47.32 11.09 71 325290 4109 79414918
Haematocrit decreased 47.31 11.09 419 324942 60893 79358134
Graft versus host disease in eye 47.25 11.09 24 325337 295 79418732
Mood altered 47.16 11.09 8 325353 17839 79401188
Disseminated aspergillosis 47.12 11.09 38 325323 1080 79417947
Hallucination, auditory 47.11 11.09 13 325348 20680 79398347
Subclavian vein thrombosis 46.96 11.09 54 325307 2403 79416624
Plasma cell myeloma refractory 46.93 11.09 31 325330 641 79418386
Pneumonia adenoviral 46.77 11.09 28 325333 484 79418543
Hyperferritinaemia 46.60 11.09 32 325329 707 79418320
Blood culture positive 46.60 11.09 105 325256 8324 79410703
Bone marrow necrosis 46.58 11.09 23 325338 265 79418762
Candida pneumonia 46.55 11.09 31 325330 650 79418377
Underdose 46.54 11.09 40 325321 33111 79385916
Ototoxicity 46.53 11.09 62 325299 3212 79415815
Product administration error 46.47 11.09 37 325324 31809 79387218
Enterovirus infection 46.29 11.09 48 325313 1899 79417128
Bone marrow transplant 46.29 11.09 42 325319 1406 79417621
Streptococcal bacteraemia 46.29 11.09 65 325296 3541 79415486
Crying 46.27 11.09 18 325343 23025 79396002
Steroid diabetes 46.20 11.09 64 325297 3442 79415585
Eye pain 46.20 11.09 51 325310 37527 79381500
Localised infection 46.19 11.09 51 325310 37524 79381503
Delusion 46.18 11.09 13 325348 20410 79398617
Poor venous access 46.09 11.09 9 325352 18140 79400887
Herpes zoster 45.86 11.09 581 324780 92502 79326525
Incorrect route of product administration 45.65 11.09 45 325316 34884 79384143
Death 45.64 11.09 1869 323492 564645 78854382
Rash macular 45.51 11.09 31 325330 28868 79390159
Febrile infection 45.48 11.09 62 325299 3284 79415743
Meningoencephalitis herpetic 45.44 11.09 48 325313 1941 79417086
Immunosuppression 45.43 11.09 135 325226 12668 79406359
Invasive lobular breast carcinoma 45.34 11.09 31 325330 680 79418347
Chronic lymphocytic leukaemia transformation 45.29 11.09 22 325339 244 79418783
Ventricular hypokinesia 45.20 11.09 110 325251 9169 79409858
Lymphocytosis 45.19 11.09 74 325287 4619 79414408
Hypofibrinogenaemia 45.18 11.09 48 325313 1954 79417073
Clostridium bacteraemia 44.98 11.09 25 325336 373 79418654
Metastases to meninges 44.88 11.09 64 325297 3537 79415490
Systemic scleroderma 44.85 11.09 38 325323 1159 79417868
Psychotic disorder 44.80 11.09 62 325299 41340 79377687
Diabetic ketoacidosis 44.55 11.09 44 325317 34078 79384949
Anaphylactic reaction 44.45 11.09 183 325178 83560 79335467
Muscle spasticity 44.42 11.09 16 325345 21459 79397568
Muscle rigidity 44.32 11.09 13 325348 19869 79399158
Acute myocardial infarction 44.32 11.09 163 325198 76873 79342154
Abnormal behaviour 44.15 11.09 50 325311 36371 79382656
Disease susceptibility 44.09 11.09 23 325338 300 79418727
Glycosylated haemoglobin increased 44.04 11.09 12 325349 19248 79399779
Toxic cardiomyopathy 43.94 11.09 25 325336 391 79418636
Iron deficiency anaemia 43.94 11.09 25 325336 25647 79393380
Retinal haemorrhage 43.92 11.09 101 325260 8116 79410911
Clostridium colitis 43.83 11.09 56 325305 2783 79416244
Cataract 43.76 11.09 120 325241 62000 79357027
Pneumonia pseudomonal 43.70 11.09 83 325278 5828 79413199
Faeces discoloured 43.57 11.09 33 325328 29094 79389933
Extrapyramidal disorder 43.46 11.09 19 325342 22660 79396367
Cardiac disorder 43.41 11.09 131 325230 65626 79353401
Adult T-cell lymphoma/leukaemia 42.98 11.09 23 325338 317 79418710
Constipation 42.96 11.09 855 324506 282195 79136832
Hyperbilirubinaemia 42.86 11.09 206 325155 24312 79394715
Lip dry 42.81 11.09 6 325355 15412 79403615
Sinus disorder 42.76 11.09 19 325342 22445 79396582
B-cell lymphoma refractory 42.69 11.09 18 325343 139 79418888
Anger 42.56 11.09 9 325352 17153 79401874
Pneumonia bacterial 42.56 11.09 174 325187 19157 79399870
Pulmonary vascular disorder 42.42 11.09 35 325326 1028 79417999
Irritability 42.17 11.09 64 325297 41080 79377947
Opportunistic infection 42.14 11.09 56 325305 2894 79416133
Pregnancy 42.02 11.09 29 325332 26822 79392205
Serum ferritin increased 41.99 11.09 111 325250 9736 79409291
Cryptococcosis 41.95 11.09 61 325300 3432 79415595
Blood pressure decreased 41.94 11.09 236 325125 99230 79319797
Pseudomonal bacteraemia 41.73 11.09 57 325304 3025 79416002
Pulmonary arteriopathy 41.49 11.09 16 325345 95 79418932
Peritonitis pneumococcal 41.32 11.09 12 325349 23 79419004
Acute lymphocytic leukaemia refractory 41.31 11.09 18 325343 152 79418875
Lower respiratory tract infection 41.27 11.09 333 325028 128887 79290140
Plasma cell myeloma 41.11 11.09 364 324997 52895 79366132
Administration site extravasation 41.07 11.09 38 325323 1305 79417722
Respirovirus test positive 40.91 11.09 17 325344 126 79418901
Dystonia 40.89 11.09 18 325343 21381 79397646
Metastases to spleen 40.88 11.09 28 325333 616 79418411
Campylobacter infection 40.86 11.09 44 325317 1819 79417208
Actinomycosis 40.86 11.09 35 325326 1084 79417943
Blood iron decreased 40.60 11.09 7 325354 15427 79403600
Delayed engraftment 40.45 11.09 21 325340 271 79418756
Anti-neutrophil cytoplasmic antibody positive vasculitis 40.32 11.09 62 325299 3667 79415360
Dehydration 40.32 11.09 741 324620 247446 79171581
Haematopoietic stem cell mobilisation 40.23 11.09 19 325342 197 79418830
Pemphigoid 40.17 11.09 7 325354 15308 79403719
Enteritis 40.16 11.09 141 325220 14442 79404585
Metastases to chest wall 40.16 11.09 26 325335 519 79418508
Sneezing 40.15 11.09 15 325346 19668 79399359
Presyncope 40.05 11.09 66 325295 40988 79378039
Glioblastoma multiforme 40.01 11.09 36 325325 1192 79417835
Ankle fracture 39.89 11.09 10 325351 16959 79402068
Restless legs syndrome 39.84 11.09 16 325345 20076 79398951
Scedosporium infection 39.84 11.09 39 325322 1439 79417588
Blast cells present 39.82 11.09 32 325329 905 79418122
Pathogen resistance 39.79 11.09 139 325222 14203 79404824
Spinal stenosis 39.74 11.09 8 325353 15783 79403244
Pulmonary mucormycosis 39.63 11.09 35 325326 1130 79417897
Amyloidosis 39.63 11.09 52 325309 2654 79416373
Hallucination, visual 39.60 11.09 45 325316 32684 79386343
Paraneoplastic pemphigus 39.48 11.09 17 325344 139 79418888
T-cell type acute leukaemia 39.30 11.09 18 325343 173 79418854
Blood potassium increased 39.09 11.09 37 325324 29238 79389789
Salivary gland cancer 39.04 11.09 24 325337 436 79418591
Tinnitus 39.00 11.09 76 325285 44257 79374770
Lupus vasculitis 38.93 11.09 26 325335 548 79418479
Rhabdomyosarcoma recurrent 38.92 11.09 16 325345 115 79418912
Extravasation 38.67 11.09 61 325300 3689 79415338
Refractory cancer 38.63 11.09 19 325342 217 79418810
Atelectasis 38.26 11.09 244 325117 32013 79387014
T-cell lymphoma 38.18 11.09 36 325325 1267 79417760
Central nervous system leukaemia 38.14 11.09 23 325338 403 79418624
Osteolysis 38.12 11.09 67 325294 4431 79414596
Feeling jittery 38.11 11.09 4 325357 12837 79406190
Neoplasm 38.10 11.09 102 325259 9014 79410013
Asthenia 38.08 11.09 1703 323658 509986 78909041
Chronic kidney disease 38.03 11.09 140 325221 66014 79353013
Choking 37.97 11.09 3 325358 12098 79406929
Therapeutic response shortened 37.97 11.09 9 325352 15854 79403173
Creatinine renal clearance decreased 37.90 11.09 15 325346 18987 79400040
Therapeutic response unexpected 37.77 11.09 17 325344 19929 79399098
Respiratory tract infection 37.70 11.09 333 325028 48356 79370671
Gallbladder disorder 37.38 11.09 16 325345 19324 79399703
Cytomegalovirus enteritis 37.17 11.09 29 325332 785 79418242
Blood pressure systolic abnormal 37.15 11.09 12 325349 17235 79401792
Dysphonia 37.04 11.09 114 325247 56758 79362269
Haemoglobin decreased 37.04 11.09 1177 324184 220942 79198085
Cyst 37.02 11.09 6 325355 13834 79405193
Secretion discharge 37.01 11.09 8 325353 15014 79404013
Out of specification test results 36.97 11.09 17 325344 165 79418862
Diabetes mellitus inadequate control 36.93 11.09 27 325334 24237 79394790
Pneumonia respiratory syncytial viral 36.90 11.09 42 325319 1848 79417179
Disability 36.72 11.09 12 325349 17108 79401919
Madarosis 36.70 11.09 51 325310 2751 79416276
Morganella infection 36.64 11.09 33 325328 1094 79417933
Lymphadenopathy mediastinal 36.63 11.09 65 325296 4331 79414696
Upper respiratory fungal infection 36.60 11.09 21 325340 334 79418693
Cytomegalovirus urinary tract infection 36.60 11.09 14 325347 81 79418946
Fungal oesophagitis 36.27 11.09 31 325330 957 79418070
Peripheral venous disease 36.21 11.09 10 325351 15899 79403128
Gastrointestinal necrosis 36.14 11.09 74 325287 5491 79413536
Chronic lymphocytic leukaemia refractory 36.12 11.09 15 325346 111 79418916
Blood immunoglobulin G decreased 35.91 11.09 56 325305 3353 79415674
West Nile viral infection 35.89 11.09 31 325330 971 79418056
Gas gangrene 35.62 11.09 19 325342 260 79418767
Cough 35.56 11.09 1183 324178 365606 79053421
Product storage error 35.46 11.09 11 325350 16215 79402812
Impaired work ability 35.39 11.09 18 325343 19663 79399364
Herpes simplex encephalitis 35.30 11.09 27 325334 709 79418318
Hypoproteinaemia 35.24 11.09 61 325300 3985 79415042
Autonomic neuropathy 35.13 11.09 41 325320 1854 79417173
Thirst 35.05 11.09 16 325345 18603 79400424
Melaena 34.91 11.09 129 325232 60761 79358266
Macular degeneration 34.90 11.09 3 325358 11293 79407734
Coronavirus infection 34.53 11.09 87 325274 7410 79411617
Stenotrophomonas infection 34.33 11.09 58 325303 3715 79415312
Hepatic candidiasis 34.31 11.09 13 325348 73 79418954
Neuroblastoma recurrent 34.27 11.09 17 325344 198 79418829
Needle issue 34.21 11.09 6 325355 13062 79405965
Angina pectoris 34.19 11.09 103 325258 51629 79367398
Glaucoma 34.17 11.09 19 325342 19742 79399285
Human herpesvirus 6 infection reactivation 34.16 11.09 24 325337 551 79418476
Psychomotor hyperactivity 34.10 11.09 13 325348 16836 79402191
Microangiopathy 33.99 11.09 40 325321 1825 79417202
Jugular vein thrombosis 33.90 11.09 64 325297 4474 79414553
Dermatitis contact 33.89 11.09 3 325358 11030 79407997
Central nervous system enteroviral infection 33.88 11.09 13 325348 76 79418951
Gastrointestinal fungal infection 33.86 11.09 23 325338 499 79418528
Cardiac arrest 33.82 11.09 496 324865 171600 79247427
Leukaemic infiltration 33.79 11.09 15 325346 133 79418894
Corynebacterium infection 33.65 11.09 34 325327 1304 79417723
Haemolytic uraemic syndrome 33.55 11.09 63 325298 4386 79414641
Babesiosis 33.54 11.09 20 325341 343 79418684
Hypertransaminasaemia 33.45 11.09 116 325245 11808 79407219
Unresponsive to stimuli 33.44 11.09 116 325245 55672 79363355
Microangiopathic haemolytic anaemia 33.38 11.09 36 325325 1491 79417536
Encephalitis enteroviral 33.31 11.09 15 325346 138 79418889
Mucosal toxicity 33.24 11.09 24 325337 576 79418451
BK polyomavirus test positive 33.22 11.09 15 325346 139 79418888
Eye disorder 33.17 11.09 28 325333 23384 79395643
SARS-CoV-2 test negative 32.96 11.09 34 325327 1337 79417690
Fungal sepsis 32.94 11.09 39 325322 1791 79417236
Rotavirus infection 32.94 11.09 26 325335 716 79418311
Disseminated toxoplasmosis 32.91 11.09 17 325344 217 79418810
Disseminated cryptococcosis 32.87 11.09 39 325322 1795 79417232
Therapeutic response decreased 32.80 11.09 417 324944 66436 79352591
Akathisia 32.79 11.09 7 325354 13252 79405775
Hydrothorax 32.78 11.09 35 325326 1433 79417594
Joint dislocation 32.76 11.09 14 325347 16925 79402102
Dysplasia 32.65 11.09 34 325327 1352 79417675
Humoral immune defect 32.62 11.09 21 325340 415 79418612
Hyperlipidaemia 32.53 11.09 35 325326 26058 79392969
Coeliac disease 32.52 11.09 4 325357 11347 79407680
Neurological symptom 32.49 11.09 94 325267 8689 79410338
Musculoskeletal disorder 32.47 11.09 24 325337 21424 79397603
Evans syndrome 32.40 11.09 21 325340 420 79418607
Coronary artery occlusion 32.38 11.09 11 325350 15304 79403723
Heart rate irregular 32.38 11.09 52 325309 32627 79386400
Lentigo 32.32 11.09 22 325339 479 79418548
Acute biphenotypic leukaemia 32.14 11.09 15 325346 151 79418876
Cerebral fungal infection 32.14 11.09 21 325340 426 79418601
Tardive dyskinesia 32.14 11.09 3 325358 10568 79408459
Invasive ductal breast carcinoma 32.13 11.09 73 325288 5819 79413208
B-lymphocyte count decreased 32.08 11.09 34 325327 1380 79417647
Morphoea 32.06 11.09 21 325340 428 79418599
Bone lesion 31.91 11.09 73 325288 5846 79413181
COVID-19 31.89 11.09 856 324505 156818 79262209
Viral load increased 31.86 11.09 49 325312 2899 79416128
Nasal cavity cancer 31.85 11.09 17 325344 233 79418794
Perineal necrosis 31.85 11.09 14 325347 121 79418906
Post-acute COVID-19 syndrome 31.77 11.09 22 325339 493 79418534
Chromaturia 31.59 11.09 35 325326 25711 79393316
Ligament sprain 31.52 11.09 8 325353 13456 79405571
Periarticular thenar erythema with onycholysis 31.47 11.09 11 325350 47 79418980
Enterocolitis infectious 31.44 11.09 48 325313 2821 79416206
Angina unstable 31.43 11.09 14 325347 16513 79402514
Multiple-drug resistance 31.37 11.09 93 325268 8715 79410312
Blood loss anaemia 31.29 11.09 12 325349 15486 79403541
Ankylosing spondylitis 31.10 11.09 6 325355 12199 79406828
Generalised oedema 31.05 11.09 184 325177 23525 79395502
Central nervous system infection 31.05 11.09 33 325328 1344 79417683
Seasonal allergy 31.04 11.09 14 325347 16392 79402635
Viral test positive 31.03 11.09 20 325341 396 79418631
Hepatitis C RNA increased 31.03 11.09 20 325341 396 79418631
Primary mediastinal large B-cell lymphoma recurrent 31.01 11.09 12 325349 72 79418955
Combined immunodeficiency 30.98 11.09 13 325348 99 79418928
Primary cardiac lymphoma 30.74 11.09 9 325352 18 79419009
Disseminated mucormycosis 30.63 11.09 25 325336 723 79418304
Skin mass 30.51 11.09 87 325274 7976 79411051
Hypertensive crisis 30.47 11.09 24 325337 20746 79398281
Rubulavirus test positive 30.41 11.09 9 325352 19 79419008
Mood swings 30.41 11.09 22 325339 19858 79399169
Gastritis bacterial 30.35 11.09 19 325342 357 79418670
Lymphadenitis 30.35 11.09 62 325299 4593 79414434
Angiocentric lymphoma 30.31 11.09 27 325334 882 79418145
Haematoma 30.31 11.09 110 325251 52085 79366942
Autoimmune lymphoproliferative syndrome 30.29 11.09 15 325346 174 79418853
Abscess bacterial 30.28 11.09 26 325335 808 79418219
Clonal evolution 30.19 11.09 16 325345 216 79418811
Metaplasia 30.04 11.09 22 325339 540 79418487
Radiation skin injury 29.94 11.09 33 325328 1401 79417626
Nail pigmentation 29.92 11.09 18 325343 314 79418713
Triple negative breast cancer 29.91 11.09 13 325348 109 79418918
Retching 29.91 11.09 17 325344 17450 79401577
Endocarditis bacterial 29.89 11.09 34 325327 1495 79417532
Hepatic infection fungal 29.80 11.09 16 325345 222 79418805
Fracture 29.77 11.09 27 325334 21774 79397253
Inflammation 29.75 11.09 242 325119 93511 79325516
Dysgeusia 29.69 11.09 126 325235 57051 79361976
Neurological decompensation 29.67 11.09 66 325295 5187 79413840
Subdural hygroma 29.67 11.09 21 325340 488 79418539
Meningoencephalitis viral 29.64 11.09 20 325341 429 79418598
Facial paresis 29.62 11.09 68 325293 5458 79413569
Rash erythematous 29.57 11.09 128 325233 57641 79361386
Ventricular tachycardia 29.54 11.09 81 325280 41854 79377173
Schizophrenia 29.48 11.09 13 325348 15427 79403600
Gastric stenosis 29.32 11.09 14 325347 149 79418878
Herpes oesophagitis 29.31 11.09 19 325342 380 79418647
Diverticulum 29.31 11.09 12 325349 14884 79404143
Hilar lymphadenopathy 29.22 11.09 37 325324 1822 79417205
Adenocarcinoma gastric 29.20 11.09 36 325325 1725 79417302
Human metapneumovirus test positive 29.14 11.09 15 325346 190 79418837
Intervertebral disc protrusion 29.10 11.09 32 325329 23589 79395438
Neuroblastoma 29.07 11.09 16 325345 234 79418793
Miosis 29.06 11.09 14 325347 15775 79403252
Cerebral venous sinus thrombosis 28.97 11.09 41 325320 2250 79416777
Recall phenomenon 28.79 11.09 29 325332 1108 79417919
Citrobacter bacteraemia 28.77 11.09 8 325353 12 79419015
Proteinuria 28.73 11.09 229 325132 32273 79386754
Pneumonia aspiration 28.71 11.09 158 325203 66809 79352218
Lumbosacral radiculoplexus neuropathy 28.71 11.09 11 325350 64 79418963
Tooth fracture 28.69 11.09 6 325355 11524 79407503
Erythropoiesis abnormal 28.66 11.09 20 325341 454 79418573
Abdominal neoplasm 28.46 11.09 22 325339 587 79418440
Chronic lymphocytic leukaemia 28.46 11.09 62 325299 4804 79414223
Appendiceal abscess 28.44 11.09 18 325343 345 79418682
Metastases to the mediastinum 28.43 11.09 22 325339 588 79418439
Blindness cortical 28.40 11.09 27 325334 960 79418067
Acinetobacter infection 28.40 11.09 45 325316 2732 79416295
Viral sinusitis 28.25 11.09 16 325345 248 79418779
Epstein Barr virus positive mucocutaneous ulcer 28.24 11.09 25 325336 810 79418217
Metastases to peritoneum 28.23 11.09 58 325303 4314 79414713
Feeling cold 28.20 11.09 46 325315 28683 79390344
Transformation to acute myeloid leukaemia 28.17 11.09 27 325334 970 79418057
Sinus bradycardia 28.13 11.09 37 325324 25210 79393817
Carpal tunnel syndrome 28.10 11.09 23 325338 19505 79399522
Lennox-Gastaut syndrome 28.01 11.09 15 325346 207 79418820
Vocal cord paralysis 27.95 11.09 43 325318 2544 79416483
Trichosporon infection 27.92 11.09 27 325334 981 79418046
Hyperviscosity syndrome 27.90 11.09 19 325342 414 79418613
Aspergilloma 27.87 11.09 22 325339 606 79418421
Cholecystectomy 27.83 11.09 3 325358 9429 79409598
Glomerulonephritis rapidly progressive 27.83 11.09 34 325327 1614 79417413
Cardiac failure congestive 27.78 11.09 411 324950 141991 79277036
Splenic candidiasis 27.76 11.09 11 325350 71 79418956
Blood creatinine increased 27.72 11.09 455 324906 154602 79264425
Acute kidney injury 27.69 11.09 1787 323574 517617 78901410
Post-depletion B-cell recovery 27.66 11.09 8 325353 15 79419012
Electrocardiogram abnormal 27.65 11.09 17 325344 16720 79402307
IIIrd nerve paralysis 27.63 11.09 29 325332 1164 79417863
Obstructive airways disorder 27.61 11.09 54 325307 31405 79387622
Disturbance in attention 27.60 11.09 110 325251 50691 79368336
Necrotising gastritis 27.50 11.09 11 325350 73 79418954
Stenotrophomonas sepsis 27.43 11.09 14 325347 174 79418853
Pneumonia viral 27.37 11.09 91 325270 9067 79409960
Acute erythroid leukaemia 27.32 11.09 16 325345 265 79418762
Germ cell cancer 27.29 11.09 14 325347 176 79418851
Metapneumovirus infection 27.24 11.09 35 325326 1749 79417278
Product dispensing error 27.23 11.09 10 325351 13253 79405774
Cellulitis gangrenous 27.22 11.09 16 325345 267 79418760
Portal hypertension 27.19 11.09 77 325284 7031 79411996
Paraesthesia oral 27.19 11.09 26 325335 20445 79398582
T-cell lymphoma stage IV 27.10 11.09 13 325348 140 79418887
Large intestine polyp 27.09 11.09 9 325352 12699 79406328
Nasal abscess 27.08 11.09 14 325347 179 79418848
Peripheral sensorimotor neuropathy 27.03 11.09 46 325315 2964 79416063
Bone erosion 26.98 11.09 20 325341 17827 79401200
Fusobacterium infection 26.98 11.09 12 325349 107 79418920
Hepatosplenic candidiasis 26.96 11.09 21 325340 567 79418460
Epstein-Barr virus test positive 26.93 11.09 28 325333 1111 79417916
Red blood cell schistocytes present 26.93 11.09 21 325340 568 79418459
Thinking abnormal 26.89 11.09 10 325351 13151 79405876
Platelet transfusion 26.83 11.09 40 325321 2302 79416725
Enterobacter bacteraemia 26.82 11.09 25 325336 867 79418160
Angioimmunoblastic T-cell lymphoma 26.71 11.09 19 325342 445 79418582
Rotator cuff syndrome 26.71 11.09 12 325349 14083 79404944
Ear pain 26.67 11.09 59 325302 32810 79386217
Cryptosporidiosis infection 26.64 11.09 23 325338 720 79418307
Dementia 26.60 11.09 37 325324 24622 79394405
Drug eruption 26.57 11.09 91 325270 43844 79375183
Nephrotic syndrome 26.54 11.09 103 325258 11071 79407956
Acute generalised exanthematous pustulosis 26.52 11.09 19 325342 17235 79401792
Medulloblastoma recurrent 26.50 11.09 12 325349 112 79418915
Joint effusion 26.20 11.09 21 325340 17993 79401034
Chromosome analysis abnormal 26.18 11.09 15 325346 238 79418789
Hiatus hernia 26.14 11.09 34 325327 23278 79395749
Emotional disorder 26.11 11.09 13 325348 14374 79404653
Osteomyelitis bacterial 26.06 11.09 19 325342 463 79418564
Gastroenteritis viral 26.05 11.09 38 325323 24793 79394234
Chromosomal deletion 25.94 11.09 13 325348 155 79418872
Lung consolidation 25.94 11.09 88 325273 8859 79410168
Lupus-like syndrome 25.94 11.09 12 325349 13845 79405182
Left ventricular dilatation 25.92 11.09 27 325334 1074 79417953
Chronic graft versus host disease in intestine 25.88 11.09 17 325344 348 79418679
Bone density decreased 25.87 11.09 11 325350 13336 79405691
Live birth 25.85 11.09 23 325338 18721 79400306
Walking aid user 25.84 11.09 5 325356 10143 79408884
Immune thrombocytopenia 25.83 11.09 142 325219 17663 79401364
Paraplegia 25.79 11.09 61 325300 4992 79414035
Leukoerythroblastosis 25.77 11.09 16 325345 296 79418731
Lethargy 25.72 11.09 210 325151 81082 79337945
Splenic marginal zone lymphoma 25.71 11.09 10 325351 61 79418966
Skin irritation 25.70 11.09 7 325354 11233 79407794
Thymus enlargement 25.70 11.09 12 325349 121 79418906
Tuberculosis of central nervous system 25.68 11.09 19 325342 474 79418553
Device breakage 25.66 11.09 6 325355 10669 79408358
Poor quality sleep 25.63 11.09 33 325328 22689 79396338
Internal haemorrhage 25.58 11.09 3 325358 8830 79410197
Aspiration bone marrow abnormal 25.58 11.09 13 325348 160 79418867
Hypercholesterolaemia 25.58 11.09 34 325327 23061 79395966
Eating disorder 25.54 11.09 28 325333 20669 79398358
Laryngitis 25.53 11.09 17 325344 16022 79403005
Necrosis 25.47 11.09 91 325270 9402 79409625
T-lymphocyte count decreased 25.45 11.09 20 325341 547 79418480
Intracardiac thrombus 25.45 11.09 55 325306 4238 79414789
Antithrombin III decreased 25.44 11.09 19 325342 481 79418546
Rib fracture 25.38 11.09 47 325314 27900 79391127
Neuroendocrine carcinoma of the skin 25.35 11.09 29 325332 1283 79417744
Listeriosis 25.16 11.09 38 325323 2212 79416815
Thyroid disorder 25.13 11.09 13 325348 14066 79404961
Natural killer-cell leukaemia 25.13 11.09 11 325350 94 79418933
Night sweats 25.12 11.09 118 325243 51977 79367050
Klebsiella test positive 25.06 11.09 33 325328 1690 79417337
Tooth development disorder 25.05 11.09 10 325351 66 79418961
Positron emission tomogram abnormal 25.02 11.09 17 325344 369 79418658
Hepatitis viral 25.00 11.09 26 325335 1032 79417995
Anaphylactic shock 25.00 11.09 70 325291 35926 79383101
Blood urine present 24.99 11.09 30 325331 21267 79397760
Head discomfort 24.99 11.09 14 325347 14488 79404539
Large intestinal ulcer perforation 24.92 11.09 10 325351 67 79418960
Cardiac murmur 24.88 11.09 17 325344 15807 79403220
Streptococcal infection 24.86 11.09 86 325275 8744 79410283
Mucosal infection 24.81 11.09 19 325342 500 79418527
Oropharyngeal pain 24.80 11.09 306 325055 109047 79309980
Geotrichum infection 24.80 11.09 25 325336 956 79418071
Mucoepidermoid carcinoma 24.79 11.09 10 325351 68 79418959
Accidental exposure to product 24.78 11.09 57 325304 31265 79387762
Autologous haematopoietic stem cell transplant 24.77 11.09 9 325352 44 79418983
Acute lung injury 24.76 11.09 45 325316 3055 79415972
Laboratory test abnormal 24.74 11.09 48 325313 28000 79391027
VIth nerve paresis 24.71 11.09 12 325349 133 79418894
Skin abrasion 24.66 11.09 12 325349 13444 79405583
CD4 lymphocytes decreased 24.65 11.09 41 325320 2593 79416434
Transaminases increased 24.65 11.09 321 325040 51422 79367605
Body height decreased 24.64 11.09 3 325358 8577 79410450
Laryngitis fungal 24.63 11.09 12 325349 134 79418893
Respiratory tract infection bacterial 24.55 11.09 36 325325 2041 79416986
Parkinsonism 24.54 11.09 19 325342 16565 79402462
Oroantral fistula 24.43 11.09 17 325344 384 79418643
Campylobacter gastroenteritis 24.42 11.09 29 325332 1336 79417691
Amenorrhoea 24.40 11.09 78 325283 7614 79411413
Pneumaturia 24.35 11.09 8 325353 27 79419000
Metastases to retroperitoneum 24.32 11.09 17 325344 387 79418640
Hair follicle tumour benign 24.23 11.09 18 325343 452 79418575
Eosinophilia 24.12 11.09 99 325262 45246 79373781
Leukaemic infiltration extramedullary 24.11 11.09 13 325348 182 79418845
Oligohydramnios 24.11 11.09 47 325314 3365 79415662
Small intestinal perforation 24.01 11.09 46 325315 3251 79415776
Acute megakaryocytic leukaemia 23.98 11.09 9 325352 49 79418978
Clear cell renal cell carcinoma 23.97 11.09 40 325321 2536 79416491
Oral disorder 23.94 11.09 93 325268 10002 79409025
Tooth disorder 23.93 11.09 44 325317 26189 79392838
Rhinorrhoea 23.85 11.09 197 325164 75877 79343150
Lymphocytic leukaemia 23.79 11.09 14 325347 234 79418793
Stevens-Johnson syndrome 23.77 11.09 81 325280 39085 79379942
Executive dysfunction 23.77 11.09 15 325346 286 79418741
Blood pressure abnormal 23.76 11.09 21 325340 17148 79401879
Metastases to muscle 23.68 11.09 16 325345 344 79418683
Depressed level of consciousness 23.64 11.09 266 325095 96386 79322641
Light chain analysis increased 23.60 11.09 32 325329 1686 79417341
Molluscum contagiosum 23.59 11.09 18 325343 471 79418556
Human rhinovirus test positive 23.59 11.09 18 325343 471 79418556
Optic atrophy 23.57 11.09 34 325327 1899 79417128
Epidermal necrosis 23.54 11.09 30 325331 1487 79417540
Ovarian disorder 23.52 11.09 18 325343 473 79418554
Gastroenteritis norovirus 23.44 11.09 44 325317 3062 79415965
Quadriplegia 23.40 11.09 46 325315 3314 79415713
Hepatic lesion 23.39 11.09 72 325289 6887 79412140
Immunodeficiency common variable 23.36 11.09 16 325345 352 79418675
Eye irritation 23.36 11.09 30 325331 20651 79398376
Anal inflammation 23.34 11.09 29 325332 1401 79417626
Blood bilirubin increased 23.33 11.09 390 324971 65842 79353185
Leukaemic lymphoma 23.31 11.09 10 325351 81 79418946
H1N1 influenza 23.29 11.09 39 325322 2480 79416547
Musculoskeletal discomfort 23.21 11.09 28 325333 19807 79399220
Dysstasia 23.18 11.09 49 325312 27697 79391330
Pain in jaw 23.17 11.09 103 325258 46048 79372979
Dyspnoea exertional 23.17 11.09 235 325126 86838 79332189
Osteonecrosis of jaw 23.10 11.09 274 325087 42952 79376075
Sputum discoloured 23.08 11.09 33 325328 21710 79397317
Chronic hepatitis 23.06 11.09 29 325332 1418 79417609
Full blood count abnormal 23.04 11.09 86 325275 40388 79378639
Toxic neuropathy 23.01 11.09 24 325337 956 79418071
Hair texture abnormal 22.96 11.09 47 325314 3487 79415540
Hepatitis B DNA increased 22.90 11.09 22 325339 793 79418234
Metastases to eye 22.84 11.09 14 325347 253 79418774
Diverticulitis 22.77 11.09 103 325258 45833 79373194
Salivary hypersecretion 22.74 11.09 15 325346 14209 79404818
Inflammatory myofibroblastic tumour 22.71 11.09 12 325349 161 79418866
Metastatic neoplasm 22.69 11.09 58 325303 4984 79414043
Mediastinum neoplasm 22.69 11.09 10 325351 87 79418940
Renal failure 22.69 11.09 1020 324341 199948 79219079
Embolism 22.67 11.09 115 325246 13867 79405160
Upper limb fracture 22.51 11.09 24 325337 17943 79401084
Unintentional medical device removal 22.49 11.09 76 325285 7636 79411391
Cerebral salt-wasting syndrome 22.41 11.09 11 325350 125 79418902
Pharyngeal oedema 22.40 11.09 20 325341 16252 79402775
Rhinitis allergic 22.39 11.09 11 325350 12258 79406769
Respiratory tract infection viral 22.38 11.09 52 325309 4207 79414820
Myocardial oedema 22.34 11.09 16 325345 379 79418648
Hepatitis B surface antigen positive 22.32 11.09 12 325349 167 79418860
PIK3CA-activated mutation 22.30 11.09 19 325342 584 79418443
Blood thyroid stimulating hormone increased 22.29 11.09 6 325355 9702 79409325
Cytotoxic oedema 22.27 11.09 16 325345 381 79418646
Meningitis tuberculous 22.22 11.09 26 325335 1179 79417848
Pelvic fracture 22.19 11.09 11 325350 12193 79406834
Transplantation complication 22.18 11.09 15 325346 323 79418704
Myositis 22.12 11.09 144 325217 19024 79400003
Palatal ulcer 22.11 11.09 11 325350 129 79418898
Wound infection 22.09 11.09 40 325321 23951 79395076
Blood urea increased 22.09 11.09 113 325248 48677 79370350
Myelodysplastic syndrome transformation 22.05 11.09 20 325341 669 79418358
Vascular injury 22.04 11.09 25 325336 1096 79417931
Listeria sepsis 21.99 11.09 21 325340 751 79418276
T-cell lymphoma recurrent 21.97 11.09 9 325352 64 79418963
Diffuse large B-cell lymphoma stage IV 21.95 11.09 18 325343 524 79418503
Drug level decreased 21.95 11.09 16 325345 14386 79404641
Acute interstitial pneumonitis 21.91 11.09 26 325335 1197 79417830
Impaired quality of life 21.90 11.09 16 325345 14370 79404657
TP53 gene mutation 21.88 11.09 8 325353 40 79418987
Metastases to spine 21.85 11.09 52 325309 4272 79414755
Diffuse large B-cell lymphoma stage II 21.84 11.09 10 325351 96 79418931
Achromobacter infection 21.82 11.09 11 325350 133 79418894
Cytokine storm 21.72 11.09 24 325337 1022 79418005
Liver function test increased 21.68 11.09 86 325275 39687 79379340
Sexual dysfunction 21.60 11.09 3 325358 7760 79411267
Retinitis viral 21.60 11.09 11 325350 136 79418891
Abnormal loss of weight 21.60 11.09 4 325357 8372 79410655
Coronary artery stenosis 21.59 11.09 12 325349 12472 79406555
Gastrointestinal haemorrhage 21.55 11.09 449 324912 147270 79271757
Hair colour changes 21.50 11.09 51 325310 4181 79414846
Cytomegalovirus enterocolitis 21.49 11.09 30 325331 1625 79417402
Superior vena cava syndrome 21.47 11.09 26 325335 1223 79417804
Drug level increased 21.45 11.09 86 325275 39565 79379462
Faeces soft 21.40 11.09 4 325357 8319 79410708
Metastases to diaphragm 21.25 11.09 8 325353 44 79418983
Malnutrition 21.25 11.09 161 325200 22341 79396686
Meningitis enteroviral 21.18 11.09 9 325352 71 79418956
Bordetella infection 21.15 11.09 10 325351 104 79418923
Gliosis 21.15 11.09 17 325344 481 79418546
Infection in an immunocompromised host 21.14 11.09 27 325334 1341 79417686
Post procedural infection 21.09 11.09 10 325351 11374 79407653
Erythropenia 21.09 11.09 16 325345 415 79418612
Pleuroparenchymal fibroelastosis 21.05 11.09 11 325350 144 79418883
Prostatic specific antigen increased 21.04 11.09 8 325353 10378 79408649
Thyroid dermatopathy 21.00 11.09 7 325354 25 79419002
Injection site induration 20.85 11.09 7 325354 9812 79409215
Tooth malformation 20.85 11.09 11 325350 147 79418880
Lymphangiosis carcinomatosa 20.79 11.09 34 325327 2120 79416907
Mantle cell lymphoma 20.79 11.09 27 325334 1364 79417663
Pneumonia parainfluenzae viral 20.76 11.09 14 325347 300 79418727
Breast cancer stage II 20.68 11.09 4 325357 8116 79410911
Hippocampal sclerosis 20.66 11.09 11 325350 150 79418877
Haemolytic anaemia 20.64 11.09 134 325227 17686 79401341
Coma scale abnormal 20.62 11.09 5 325356 8673 79410354
Skin fissures 20.61 11.09 14 325347 13059 79405968
Mydriasis 20.55 11.09 25 325336 17618 79401409
Arteritis 20.52 11.09 22 325339 905 79418122
Haemolysis 20.51 11.09 105 325256 12707 79406320
Pharyngitis streptococcal 20.49 11.09 9 325352 10705 79408322
Streptococcal sepsis 20.49 11.09 40 325321 2867 79416160
Low density lipoprotein increased 20.43 11.09 5 325356 8617 79410410
Obesity 20.41 11.09 74 325287 35051 79383976
Follicular lymphoma 20.38 11.09 15 325346 371 79418656
Tenosynovitis 20.37 11.09 20 325341 15534 79403493
Pleural mass 20.35 11.09 9 325352 79 79418948
Oesophagitis 20.31 11.09 169 325192 24120 79394907
Atypical haemolytic uraemic syndrome 20.26 11.09 23 325338 1009 79418018
Deformity 20.13 11.09 7 325354 9598 79409429
Marrow hyperplasia 20.11 11.09 29 325332 1619 79417408
Chylothorax 20.05 11.09 20 325341 755 79418272
Arteriosclerosis 20.02 11.09 27 325334 18200 79400827
CSF protein increased 20.00 11.09 25 325336 1215 79417812
Muscle strain 19.97 11.09 7 325354 9548 79409479
Ventricular dysfunction 19.95 11.09 62 325299 5961 79413066
Ureaplasma infection 19.94 11.09 23 325338 1027 79418000
Urinary retention 19.94 11.09 142 325219 56488 79362539
Pneumococcal infection 19.92 11.09 22 325339 936 79418091
Pyloric stenosis 19.91 11.09 17 325344 524 79418503
Skin burning sensation 19.90 11.09 15 325346 13257 79405770
Blindness 19.89 11.09 190 325171 28193 79390834
Blood pressure diastolic increased 19.87 11.09 18 325343 14524 79404503
Herpes zoster cutaneous disseminated 19.83 11.09 16 325345 455 79418572
Myoclonus 19.80 11.09 53 325308 27607 79391420
Blood potassium decreased 19.79 11.09 110 325251 46402 79372625
Peritonitis viral 19.76 11.09 8 325353 55 79418972
Disseminated cytomegaloviral infection 19.71 11.09 16 325345 459 79418568
Superior sagittal sinus thrombosis 19.71 11.09 23 325338 1040 79417987
Vitamin B12 deficiency 19.68 11.09 3 325358 7238 79411789
Cardiac cirrhosis 19.67 11.09 12 325349 215 79418812
Photosensitivity reaction 19.66 11.09 35 325326 21092 79397935
Electrocardiogram ST segment elevation 19.64 11.09 5 325356 8392 79410635
Cryptococcal fungaemia 19.56 11.09 11 325350 168 79418859
Pneumothorax 19.55 11.09 189 325172 28134 79390893
Capnocytophaga infection 19.54 11.09 10 325351 125 79418902
Cerebellar haemangioma 19.51 11.09 9 325352 88 79418939
Product dose omission in error 19.49 11.09 4 325357 7784 79411243
Human herpesvirus 7 infection 19.47 11.09 10 325351 126 79418901
Renal cancer 19.40 11.09 13 325348 12213 79406814
Carbohydrate antigen 15-3 increased 19.39 11.09 24 325337 1155 79417872
Inappropriate antidiuretic hormone secretion 19.37 11.09 178 325183 26135 79392892
Precursor T-lymphoblastic lymphoma/leukaemia 19.34 11.09 9 325352 90 79418937
Central nervous system mass 19.34 11.09 11 325350 172 79418855
Extramedullary haemopoiesis 19.33 11.09 10 325351 128 79418899
Food allergy 19.31 11.09 10 325351 10814 79408213
Malassezia infection 19.31 11.09 7 325354 34 79418993
Lymphomatoid papulosis 19.28 11.09 14 325347 339 79418688
Decreased appetite 19.27 11.09 1172 324189 341246 79077781
Bone sarcoma 19.17 11.09 9 325352 92 79418935
Carotid intima-media thickness increased 19.17 11.09 9 325352 92 79418935
Ischaemic cardiomyopathy 19.16 11.09 4 325357 7691 79411336
Brachydactyly 19.14 11.09 7 325354 35 79418992
Marginal zone lymphoma recurrent 19.14 11.09 7 325354 35 79418992
Sleep disorder due to a general medical condition 19.11 11.09 18 325343 14259 79404768
Lung adenocarcinoma 19.10 11.09 73 325288 7791 79411236
Device electrical impedance issue 19.08 11.09 5 325356 5 79419022
Hemianopia 19.06 11.09 29 325332 1699 79417328
Ewing's sarcoma recurrent 19.04 11.09 6 325355 17 79419010
Central nervous system vasculitis 19.00 11.09 26 325335 1382 79417645
Mycobacterium kansasii infection 18.96 11.09 14 325347 348 79418679
Facial paralysis 18.92 11.09 149 325212 20923 79398104
Ameloblastoma 18.92 11.09 9 325352 95 79418932
Lung diffusion test decreased 18.91 11.09 25 325336 1285 79417742
Drug level above therapeutic 18.91 11.09 6 325355 8717 79410310
Atrioventricular block first degree 18.88 11.09 14 325347 12477 79406550
Necrotising fasciitis 18.87 11.09 61 325300 5989 79413038
Muscle tightness 18.85 11.09 15 325346 12899 79406128
Peripheral T-cell lymphoma unspecified stage IV 18.82 11.09 7 325354 37 79418990
Diaphragm muscle weakness 18.79 11.09 11 325350 182 79418845
Hormone receptor positive breast cancer 18.79 11.09 14 325347 353 79418674
Ocular lymphoma 18.75 11.09 9 325352 97 79418930
Stomatococcal infection 18.75 11.09 13 325348 292 79418735
Intestinal atresia 18.73 11.09 8 325353 64 79418963
Karyotype analysis abnormal 18.67 11.09 7 325354 38 79418989
Soft tissue infection 18.65 11.09 46 325315 3866 79415161
Hepatic calcification 18.62 11.09 14 325347 358 79418669
Pharyngeal inflammation 18.62 11.09 22 325339 1008 79418019
Hypomania 18.62 11.09 4 325357 7540 79411487
Kaposi's sarcoma 18.57 11.09 19 325342 740 79418287
Haemorrhagic stroke 18.56 11.09 11 325350 11035 79407992
Precursor T-lymphoblastic lymphoma/leukaemia recurrent 18.55 11.09 6 325355 19 79419008
Obstruction gastric 18.54 11.09 29 325332 1741 79417286
Herpes zoster meningoencephalitis 18.52 11.09 19 325342 742 79418285
Lipidosis 18.52 11.09 7 325354 39 79418988
Viral cardiomyopathy 18.52 11.09 7 325354 39 79418988
Frustration tolerance decreased 18.47 11.09 4 325357 7498 79411529
Mucosal disorder 18.45 11.09 43 325318 3485 79415542
Granulomatosis with polyangiitis 18.44 11.09 38 325323 2832 79416195
Eosinophilic cystitis 18.43 11.09 9 325352 101 79418926
Synovial cyst 18.41 11.09 9 325352 10056 79408971
Large intestine perforation 18.41 11.09 112 325249 14455 79404572
Alternaria infection 18.39 11.09 18 325343 664 79418363
Dermatitis atopic 18.38 11.09 9 325352 10047 79408980
Peripheral vascular disorder 18.37 11.09 5 325356 8025 79411002
Mesenteric abscess 18.36 11.09 10 325351 143 79418884
Hepatic amoebiasis 18.36 11.09 9 325352 102 79418925
Transplant dysfunction 18.34 11.09 68 325293 7153 79411874
Primary immunodeficiency syndrome 18.31 11.09 8 325353 68 79418959
Cholangiocarcinoma 18.30 11.09 35 325326 2471 79416556
Scar 18.27 11.09 21 325340 15175 79403852
Plasmablastic lymphoma 18.26 11.09 16 325345 511 79418516
Increased tendency to bruise 18.18 11.09 10 325351 10454 79408573
Hemiparesis 18.10 11.09 214 325147 33519 79385508
Groin pain 18.10 11.09 16 325345 13064 79405963
Precursor B-lymphoblastic lymphoma recurrent 18.10 11.09 6 325355 21 79419006
Adenoviral upper respiratory infection 18.02 11.09 4 325357 0 79419027
Arterial occlusive disease 18.01 11.09 6 325355 8450 79410577
Alopecia totalis 18.00 11.09 14 325347 377 79418650
Renal amyloidosis 18.00 11.09 10 325351 149 79418878
Sinus polyp 17.98 11.09 16 325345 522 79418505
Cushingoid 17.97 11.09 82 325279 9470 79409557
Intussusception 17.94 11.09 23 325338 1147 79417880
Trichodysplasia spinulosa 17.89 11.09 19 325342 773 79418254
Non-Hodgkin's lymphoma recurrent 17.88 11.09 6 325355 22 79419005
Growth retardation 17.85 11.09 30 325331 1913 79417114
CSF test abnormal 17.85 11.09 16 325345 527 79418500
Dislocation of vertebra 17.85 11.09 5 325356 7875 79411152
Sarcoma metastatic 17.82 11.09 8 325353 73 79418954
T-cell prolymphocytic leukaemia 17.82 11.09 7 325354 44 79418983
Drug tolerance decreased 17.81 11.09 16 325345 12962 79406065
Adenocarcinoma 17.80 11.09 45 325316 3841 79415186
Lymph node fibrosis 17.78 11.09 5 325356 8 79419019
Spinal cord disorder 17.76 11.09 29 325332 1806 79417221
Xanthogranuloma 17.73 11.09 8 325353 74 79418953
Lymphadenitis viral 17.73 11.09 8 325353 74 79418953
Acute pulmonary oedema 17.72 11.09 109 325252 14121 79404906
Roseolovirus test positive 17.65 11.09 11 325350 205 79418822
Exophthalmos 17.64 11.09 28 325333 1702 79417325
Tooth hypoplasia 17.60 11.09 11 325350 206 79418821
Miller Fisher syndrome 17.60 11.09 12 325349 262 79418765
Post procedural complication 17.56 11.09 45 325316 23784 79395243
Haematocolpos 17.56 11.09 7 325354 46 79418981
Leukonychia 17.56 11.09 7 325354 46 79418981
VIth nerve paralysis 17.56 11.09 27 325334 1597 79417430
Vaccination failure 17.55 11.09 29 325332 1824 79417203
Spinal disorder 17.55 11.09 10 325351 10250 79408777
Fungal test positive 17.52 11.09 22 325339 1074 79417953
Speech disorder 17.52 11.09 140 325221 54305 79364722
Incorrect product administration duration 17.50 11.09 14 325347 12008 79407019
Helicobacter sepsis 17.48 11.09 6 325355 24 79419003
Paraesthesia 17.46 11.09 567 324794 175756 79243271
Tension headache 17.44 11.09 4 325357 7207 79411820
Liver scan abnormal 17.43 11.09 7 325354 47 79418980
Mantle cell lymphoma refractory 17.41 11.09 9 325352 115 79418912
Increased appetite 17.37 11.09 14 325347 11964 79407063
Paranoia 17.36 11.09 33 325328 19399 79399628
Microscopic polyangiitis 17.33 11.09 14 325347 399 79418628
Cranial nerve disorder 17.30 11.09 22 325339 1088 79417939
Hypogonadism 17.28 11.09 28 325333 1732 79417295
Neurofibrosarcoma 17.28 11.09 11 325350 213 79418814
Personality change 17.27 11.09 10 325351 10160 79408867
Ureteric compression 17.25 11.09 12 325349 271 79418756
Acute polyneuropathy 17.23 11.09 15 325346 475 79418552
Lymphoplasmacytoid lymphoma/immunocytoma recurrent 17.08 11.09 5 325356 10 79419017
Brain stem syndrome 17.07 11.09 20 325341 908 79418119
Viral sepsis 17.06 11.09 10 325351 166 79418861
Mitral valve incompetence 17.04 11.09 185 325176 28380 79390647
Hepatic necrosis 17.03 11.09 78 325283 9022 79410005
Ill-defined disorder 17.03 11.09 179 325182 65696 79353331
Myocarditis 17.01 11.09 149 325212 21584 79397443
Metastatic lymphoma 17.01 11.09 13 325348 341 79418686
Ovarian cyst 16.89 11.09 16 325345 12639 79406388
Hepatic cirrhosis 16.87 11.09 79 325282 34827 79384200
Cerebellar syndrome 16.87 11.09 55 325306 5425 79413602
Ulcer 16.85 11.09 64 325297 29908 79389119
Soft tissue neoplasm 16.85 11.09 8 325353 84 79418943
Erectile dysfunction 16.85 11.09 21 325340 14643 79404384
Acanthamoeba infection 16.84 11.09 15 325346 490 79418537
Polyp 16.84 11.09 6 325355 8101 79410926
Tumour necrosis 16.77 11.09 29 325332 1893 79417134
Enteral nutrition 16.77 11.09 8 325353 85 79418942
Glottis carcinoma 16.76 11.09 5 325356 11 79419016
Disorder of orbit 16.76 11.09 9 325352 125 79418902
Primary mediastinal large B-cell lymphoma 16.74 11.09 6 325355 28 79418999
N-terminal prohormone brain natriuretic peptide increased 16.74 11.09 50 325311 4705 79414322
Pneumonia pneumococcal 16.70 11.09 45 325316 3992 79415035
Septic embolus 16.67 11.09 30 325331 2021 79417006
Post lumbar puncture syndrome 16.66 11.09 18 325343 747 79418280
Dermatomyositis 16.64 11.09 42 325319 3581 79415446
Device pacing issue 16.63 11.09 9 325352 127 79418900
Pathological fracture 16.62 11.09 86 325275 10451 79408576
Lupus myocarditis 16.61 11.09 8 325353 87 79418940
Paratracheal lymphadenopathy 16.54 11.09 10 325351 176 79418851
Respiratory rate increased 16.54 11.09 40 325321 21560 79397467
Adenocarcinoma of colon 16.51 11.09 55 325306 5486 79413541
Li-Fraumeni syndrome 16.46 11.09 5 325356 12 79419015
Enterovirus test positive 16.44 11.09 12 325349 293 79418734
Vaginal discharge 16.42 11.09 5 325356 7458 79411569
Radiation necrosis 16.41 11.09 14 325347 431 79418596
Clostridial infection 16.39 11.09 56 325305 5658 79413369
Anorectal cellulitis 16.37 11.09 8 325353 90 79418937
Cardiac amyloidosis 16.37 11.09 28 325333 1812 79417215
Tissue infiltration 16.36 11.09 17 325344 674 79418353
Muscular weakness 16.36 11.09 515 324846 160214 79258813
Tracheo-oesophageal fistula 16.35 11.09 16 325345 590 79418437
Basal ganglion degeneration 16.33 11.09 14 325347 434 79418593
Parvovirus infection 16.32 11.09 17 325344 676 79418351
Aphonia 16.32 11.09 11 325350 10301 79408726
Paranasal sinus mucosal hypertrophy 16.29 11.09 8 325353 91 79418936
Occult blood positive 16.29 11.09 4 325357 6879 79412148
Aortic arteriosclerosis 16.27 11.09 8 325353 8910 79410117
High-grade B-cell lymphoma 16.27 11.09 9 325352 133 79418894
Squamous cell carcinoma of the oral cavity 16.26 11.09 15 325346 513 79418514
Chronic hepatitis B 16.25 11.09 14 325347 437 79418590
Herpes simplex viraemia 16.25 11.09 14 325347 437 79418590
Primitive neuroectodermal tumour 16.25 11.09 6 325355 31 79418996
Non-Hodgkin's lymphoma 16.22 11.09 25 325336 1482 79417545
Enterovesical fistula 16.21 11.09 22 325339 1160 79417867
Deep vein thrombosis 16.21 11.09 625 324736 120294 79298733
Brain oedema 16.19 11.09 166 325195 25097 79393930
Autologous bone marrow transplantation therapy 16.18 11.09 5 325356 13 79419014
Paresis 16.15 11.09 46 325315 4215 79414812
Bacteroides bacteraemia 16.14 11.09 8 325353 93 79418934
Dizziness postural 16.13 11.09 14 325347 11535 79407492
Haematemesis 16.08 11.09 136 325225 52128 79366899
CD4/CD8 ratio decreased 16.08 11.09 7 325354 59 79418968
Cutaneous T-cell lymphoma recurrent 16.08 11.09 7 325354 59 79418968
Keratopathy 16.04 11.09 22 325339 1172 79417855
Retinal toxicity 16.02 11.09 24 325337 1387 79417640
Ketoacidosis 15.99 11.09 6 325355 7848 79411179
Meningitis enterococcal 15.99 11.09 8 325353 95 79418932
Foetal growth restriction 15.97 11.09 30 325331 2089 79416938
Myelofibrosis 15.95 11.09 33 325328 2467 79416560
Renal cell carcinoma 15.92 11.09 61 325300 6517 79412510
Jejunal stenosis 15.92 11.09 8 325353 96 79418931
Viral skin infection 15.92 11.09 8 325353 96 79418931
Pulmonary tuberculosis 15.92 11.09 69 325292 7796 79411231
Borrelia infection 15.90 11.09 11 325350 246 79418781
Infusion site swelling 15.90 11.09 6 325355 7820 79411207
Vitamin D decreased 15.90 11.09 10 325351 9715 79409312
Retroperitoneal lymphadenopathy 15.89 11.09 21 325340 1079 79417948
Blood test abnormal 15.89 11.09 30 325331 17680 79401347
Perineal infection 15.87 11.09 18 325343 789 79418238
Blood pressure inadequately controlled 15.82 11.09 3 325358 6174 79412853
Renal pain 15.82 11.09 7 325354 8289 79410738
Cytokine abnormal 15.80 11.09 4 325357 3 79419024
Inflammatory pseudotumour 15.78 11.09 7 325354 62 79418965
Blood glucose abnormal 15.77 11.09 12 325349 10554 79408473
Carotid artery stenosis 15.76 11.09 8 325353 8750 79410277
Intervertebral disc degeneration 15.75 11.09 25 325336 15760 79403267
Haemorrhage 15.75 11.09 269 325092 90849 79328178
Arthritis infective 15.74 11.09 7 325354 8264 79410763
Hydrocephalus 15.71 11.09 75 325286 8825 79410202
Joint neoplasm 15.68 11.09 7 325354 63 79418964
Disorientation 15.65 11.09 172 325189 62604 79356423
Hepatic infarction 15.65 11.09 19 325342 896 79418131
Gastrointestinal motility disorder 15.62 11.09 3 325358 6119 79412908
Pneumonia necrotising 15.58 11.09 22 325339 1205 79417822
Pharyngeal swelling 15.55 11.09 6 325355 7713 79411314
Pulmonary thrombosis 15.54 11.09 16 325345 12155 79406872
Herpes simplex reactivation 15.52 11.09 14 325347 465 79418562
Productive cough 15.52 11.09 260 325101 88071 79330956
Mucocutaneous haemorrhage 15.52 11.09 10 325351 198 79418829
Basophilia 15.51 11.09 6 325355 36 79418991
Sphingomonas paucimobilis infection 15.49 11.09 8 325353 102 79418925
Post procedural haemorrhage 15.46 11.09 20 325341 13724 79405303
Hypodontia 15.42 11.09 5 325356 16 79419011
Mass 15.38 11.09 123 325238 17349 79401678
Viral vasculitis 15.37 11.09 9 325352 149 79418878
Hepatitis B e antigen positive 15.37 11.09 6 325355 37 79418990
Necrotising retinitis 15.33 11.09 22 325339 1223 79417804
Mucosal erosion 15.26 11.09 31 325330 2287 79416740
Papilloedema 15.25 11.09 58 325303 6175 79412852
Subacute combined cord degeneration 15.25 11.09 12 325349 329 79418698
POEMS syndrome 15.24 11.09 6 325355 38 79418989
Periostitis 15.21 11.09 16 325345 644 79418383
Adult T-cell lymphoma/leukaemia recurrent 15.19 11.09 5 325356 17 79419010
Dermatitis allergic 15.16 11.09 32 325329 18098 79400929
Platelet count abnormal 15.15 11.09 49 325312 4813 79414214
Neutrophil percentage decreased 15.13 11.09 18 325343 831 79418196
Granulicatella infection 15.09 11.09 8 325353 108 79418919
Pulmonary sarcoidosis 15.04 11.09 23 325338 1354 79417673
Pancreatic carcinoma 15.02 11.09 20 325341 13557 79405470
Skin haemorrhage 15.02 11.09 16 325345 11965 79407062
Urinary bladder rupture 14.97 11.09 8 325353 110 79418917
Central nervous system neoplasm 14.97 11.09 8 325353 110 79418917
Metastases to uterus 14.95 11.09 7 325354 71 79418956
Arthropod bite 14.86 11.09 8 325353 8463 79410564
Transient hypogammaglobulinaemia of infancy 14.85 11.09 6 325355 41 79418986
Skin cancer 14.84 11.09 24 325337 15016 79404011
Mediastinal mass 14.83 11.09 15 325346 576 79418451
Vaginal infection 14.75 11.09 3 325358 5877 79413150
Hypouricaemia 14.74 11.09 13 325348 419 79418608
Abdominal pain lower 14.74 11.09 73 325288 31709 79387318
Pleural disorder 14.72 11.09 19 325342 954 79418073
Breast cancer female 14.71 11.09 15 325346 11446 79407581
Bronchiolitis 14.71 11.09 44 325317 4144 79414883
Citrobacter sepsis 14.70 11.09 7 325354 74 79418953
Drug clearance decreased 14.69 11.09 38 325323 3289 79415738
Gastrointestinal candidiasis 14.69 11.09 13 325348 421 79418606
Alanine aminotransferase abnormal 14.66 11.09 9 325352 8858 79410169
Adverse reaction 14.65 11.09 10 325351 9304 79409723
Hepatosplenic T-cell lymphoma 14.64 11.09 18 325343 860 79418167
Fungal skin infection 14.63 11.09 56 325305 5980 79413047
Sickle cell anaemia with crisis 14.61 11.09 7 325354 7915 79411112
Infusion site eschar 14.56 11.09 5 325356 20 79419007
Cerebrosclerosis 14.56 11.09 5 325356 20 79419007
Extrasystoles 14.56 11.09 6 325355 7413 79411614
Metastases to heart 14.54 11.09 11 325350 284 79418743
Intentional dose omission 14.51 11.09 9 325352 8808 79410219
Gastrointestinal mucormycosis 14.48 11.09 13 325348 429 79418598
Candida endophthalmitis 14.47 11.09 9 325352 167 79418860
Pleural neoplasm 14.44 11.09 12 325349 356 79418671
Transitional cell carcinoma 14.43 11.09 32 325329 2509 79416518
Pollakiuria 14.42 11.09 91 325270 37226 79381801
Systolic dysfunction 14.41 11.09 41 325320 3754 79415273
Neuromuscular toxicity 14.41 11.09 10 325351 225 79418802
Device related bacteraemia 14.39 11.09 16 325345 686 79418341
Reproductive toxicity 14.38 11.09 4 325357 6 79419021
Gastric pneumatosis 14.37 11.09 5 325356 21 79419006
Pneumonia measles 14.37 11.09 5 325356 21 79419006
Anaplastic large-cell lymphoma 14.37 11.09 10 325351 226 79418801
Infusion site streaking 14.36 11.09 14 325347 514 79418513
Diabetes mellitus 14.34 11.09 229 325132 78161 79340866
Tooth infection 14.32 11.09 35 325326 18797 79400230
Burkitt's lymphoma 14.30 11.09 8 325353 121 79418906
Vomiting 14.28 11.09 2444 322917 663384 78755643
Granuloma skin 14.23 11.09 10 325351 9164 79409863
Onychomycosis 14.20 11.09 8 325353 8253 79410774
Wall motion score index abnormal 14.20 11.09 9 325352 173 79418854
Meningeal neoplasm 14.19 11.09 5 325356 22 79419005
Follicular mucinosis 14.19 11.09 5 325356 22 79419005
Lymphoplasmacytoid lymphoma/immunocytoma 14.16 11.09 6 325355 47 79418980
Empyema 14.15 11.09 44 325317 4232 79414795
Affect lability 14.15 11.09 15 325346 11244 79407783
Intestinal obstruction 14.13 11.09 110 325251 42910 79376117
Erysipelas 14.08 11.09 84 325277 10766 79408261
Ankle brachial index decreased 14.08 11.09 7 325354 82 79418945
Tongue disorder 14.07 11.09 22 325339 13953 79405074
Acral lentiginous melanoma 14.05 11.09 6 325355 48 79418979
Atypical teratoid/rhabdoid tumour of CNS 14.01 11.09 5 325356 23 79419004
Respiratory acidosis 13.99 11.09 15 325346 11185 79407842
Apraxia 13.98 11.09 34 325327 2833 79416194
Anal infection 13.97 11.09 9 325352 178 79418849
Blood chloride decreased 13.94 11.09 8 325353 8169 79410858
Blastic plasmacytoid dendritic cell neoplasia 13.93 11.09 7 325354 84 79418943
Aplasia pure red cell 13.92 11.09 66 325295 7744 79411283
Psychomotor retardation 13.87 11.09 4 325357 6180 79412847
Pulse waveform abnormal 13.86 11.09 7 325354 85 79418942
Hereditary motor and sensory neuropathy 13.85 11.09 8 325353 129 79418898
Cholecystitis chronic 13.85 11.09 12 325349 9894 79409133
Jaw operation 13.83 11.09 17 325344 812 79418215
Blood triglycerides increased 13.82 11.09 42 325319 20998 79398029
Dysgraphia 13.82 11.09 42 325319 3990 79415037
Disseminated tuberculosis 13.80 11.09 43 325318 4140 79414887
Gastric perforation 13.79 11.09 42 325319 3995 79415032
Premature ageing 13.78 11.09 7 325354 86 79418941
Squamous cell carcinoma 13.77 11.09 110 325251 15512 79403515
Cryoglobulinaemia 13.77 11.09 17 325344 816 79418211
Pneumonitis chemical 13.75 11.09 13 325348 459 79418568
Toothache 13.75 11.09 39 325322 19931 79399096
Urinary bladder toxicity 13.67 11.09 5 325356 25 79419002
Oophoritis 13.64 11.09 7 325354 88 79418939
Conus medullaris syndrome 13.63 11.09 6 325355 52 79418975
Bacillus infection 13.62 11.09 20 325341 1135 79417892
Kidney transplant rejection 13.62 11.09 13 325348 10233 79408794
Viral infection 13.61 11.09 249 325112 42767 79376260
Micturition urgency 13.60 11.09 19 325342 12622 79406405
Herpes zoster reactivation 13.59 11.09 9 325352 187 79418840
Epstein-Barr virus antigen positive 13.57 11.09 7 325354 89 79418938
Monocyte count decreased 13.56 11.09 36 325325 3165 79415862
Pulmonary hypoplasia 13.54 11.09 6 325355 53 79418974
Neuroborreliosis 13.53 11.09 8 325353 135 79418892
Peliosis hepatis 13.53 11.09 8 325353 135 79418892
Breast angiosarcoma 13.52 11.09 3 325358 0 79419027
Precursor B-lymphoblastic lymphoma refractory 13.52 11.09 3 325358 0 79419027
Urinary bladder atrophy 13.52 11.09 3 325358 0 79419027
Cutaneous T-cell lymphoma refractory 13.52 11.09 3 325358 0 79419027
Varicella 13.48 11.09 34 325327 2898 79416129
B-cell lymphoma stage IV 13.44 11.09 7 325354 91 79418936
Sluggishness 13.42 11.09 5 325356 6567 79412460
Essential hypertension 13.42 11.09 4 325357 6049 79412978
Mucocutaneous ulceration 13.39 11.09 12 325349 395 79418632
Ageusia 13.37 11.09 30 325331 16602 79402425
Prostatic abscess 13.37 11.09 12 325349 396 79418631
Merycism 13.36 11.09 10 325351 254 79418773
Mycobacterial infection 13.32 11.09 39 325322 3629 79415398
Haemophilus infection 13.31 11.09 29 325332 2247 79416780
Blast cell count increased 13.26 11.09 22 325339 1388 79417639
Cold sweat 13.26 11.09 36 325325 18663 79400364
Anosmia 13.25 11.09 10 325351 8834 79410193
Mixed anxiety and depressive disorder 13.24 11.09 12 325349 401 79418626
Spinal osteoarthritis 13.23 11.09 31 325330 16896 79402131
Citrobacter infection 13.22 11.09 18 325343 952 79418075
Eructation 13.20 11.09 15 325346 10894 79408133
Refractoriness to platelet transfusion 13.18 11.09 8 325353 142 79418885
Hepatitis D 13.17 11.09 7 325354 95 79418932
Corynebacterium sepsis 13.16 11.09 6 325355 57 79418970
Enterobacter sepsis 13.16 11.09 20 325341 1171 79417856
Systemic inflammatory response syndrome 13.15 11.09 86 325275 11379 79407648
Cardiac septal defect 13.11 11.09 11 325350 331 79418696
Glomerular filtration rate decreased 13.08 11.09 48 325313 22654 79396373
Microgenia 13.05 11.09 4 325357 10 79419017
Stomatitis necrotising 13.02 11.09 9 325352 201 79418826
Polyserositis 13.00 11.09 15 325346 670 79418357
Meningitis 12.96 11.09 75 325286 9507 79409520
Cytomegalovirus hepatitis 12.96 11.09 16 325345 768 79418259
Oedema 12.94 11.09 380 324981 119200 79299827
Complication associated with device 12.93 11.09 33 325328 17463 79401564
Myasthenia gravis 12.91 11.09 14 325347 10385 79408642
Interleukin level increased 12.90 11.09 14 325347 584 79418443
Meningitis bacterial 12.89 11.09 32 325329 2700 79416327
Emphysematous cholecystitis 12.89 11.09 6 325355 60 79418967
Blood HIV RNA increased 12.89 11.09 25 325336 1783 79417244
Arteriosclerosis coronary artery 12.86 11.09 34 325327 17782 79401245
Scleroderma renal crisis 12.84 11.09 14 325347 587 79418440
Urethral obstruction 12.84 11.09 10 325351 270 79418757
Arachnoid cyst 12.83 11.09 11 325350 341 79418686
Endocardial fibrosis 12.81 11.09 6 325355 61 79418966
Cardiac tamponade 12.80 11.09 73 325288 9203 79409824
Lung neoplasm 12.79 11.09 60 325301 7009 79412018
Median nerve injury 12.79 11.09 5 325356 31 79418996
Duodenal ulcer 12.78 11.09 30 325331 16339 79402688
Cyanosis 12.76 11.09 56 325305 25126 79393901
Eye infection 12.74 11.09 18 325343 11902 79407125
Escherichia test positive 12.74 11.09 35 325326 3140 79415887
Peripheral coldness 12.68 11.09 29 325332 15941 79403086
Norovirus infection 12.67 11.09 15 325346 689 79418338
Gait apraxia 12.65 11.09 5 325356 32 79418995
Glomerulosclerosis 12.62 11.09 19 325342 1103 79417924
Polyomavirus test positive 12.57 11.09 9 325352 213 79418814
Hepatitis 12.56 11.09 307 325054 55420 79363607
Scrotal cellulitis 12.53 11.09 4 325357 12 79419015
Lineage switch leukaemia 12.53 11.09 4 325357 12 79419015
Abdominal compartment syndrome 12.53 11.09 23 325338 1574 79417453
Mental impairment 12.51 11.09 38 325323 18998 79400029
Wrong product administered 12.50 11.09 11 325350 9001 79410026
Intracranial pressure increased 12.49 11.09 67 325294 8255 79410772
Hyponatraemic coma 12.47 11.09 6 325355 65 79418962
Bradyphrenia 12.47 11.09 15 325346 10625 79408402
Cystoid macular oedema 12.47 11.09 26 325335 1954 79417073
Gastroenteritis cryptosporidial 12.47 11.09 10 325351 282 79418745
Metastases to stomach 12.47 11.09 10 325351 282 79418745
Staphylococcus test positive 12.47 11.09 56 325305 6425 79412602
Ileal perforation 12.46 11.09 18 325343 1007 79418020
Meniscus injury 12.46 11.09 6 325355 6762 79412265
Central nervous system necrosis 12.44 11.09 10 325351 283 79418744
Monoparesis 12.44 11.09 37 325324 3474 79415553
Cardiac failure acute 12.42 11.09 125 325236 18804 79400223
Perineal ulceration 12.39 11.09 6 325355 66 79418961
Pyomyositis 12.39 11.09 14 325347 611 79418416
Genital haemorrhage 12.37 11.09 5 325356 6250 79412777
Cardiac valve disease 12.35 11.09 4 325357 5737 79413290
Hepatic vein occlusion 12.32 11.09 9 325352 220 79418807
Left ventricular failure 12.32 11.09 74 325287 9507 79409520
Herpes sepsis 12.29 11.09 4 325357 13 79419014
Splenic infection fungal 12.28 11.09 7 325354 110 79418917
Micrococcus infection 12.28 11.09 7 325354 110 79418917
Haemorrhage intracranial 12.27 11.09 162 325199 26031 79392996
Anogenital warts 12.23 11.09 17 325344 917 79418110
Fasciitis 12.22 11.09 16 325345 815 79418212
Opsoclonus myoclonus 12.22 11.09 9 325352 223 79418804
Gastrointestinal inflammation 12.20 11.09 62 325299 7482 79411545
Bronchospasm 12.17 11.09 56 325305 24803 79394224
Tidal volume decreased 12.16 11.09 6 325355 69 79418958
Hypermetabolism 12.15 11.09 11 325350 367 79418660
Transplant rejection 12.11 11.09 127 325234 19310 79399717
Tongue fungal infection 12.09 11.09 6 325355 70 79418957
Tongue oedema 12.08 11.09 7 325354 7110 79411917
Tendon pain 12.07 11.09 4 325357 5654 79413373
Vasculitis 12.07 11.09 156 325205 24946 79394081
Biopsy lymph gland 12.06 11.09 7 325354 114 79418913
Pneumococcal bacteraemia 12.06 11.09 7 325354 114 79418913
Food protein-induced enterocolitis syndrome 12.04 11.09 5 325356 37 79418990
JC virus CSF test positive 12.00 11.09 8 325353 168 79418859
Listeria encephalitis 11.97 11.09 10 325351 299 79418728
Cerebellar stroke 11.91 11.09 13 325348 546 79418481
Arrhythmia 11.89 11.09 177 325184 61095 79357932
Splenic necrosis 11.88 11.09 8 325353 171 79418856
Hyperlactacidaemia 11.86 11.09 4 325357 5591 79413436
Metastases to tonsils 11.85 11.09 4 325357 15 79419012
Hypoglossal nerve paresis 11.85 11.09 7 325354 118 79418909
Chronic cutaneous lupus erythematosus 11.84 11.09 12 325349 462 79418565
Ureteric dilatation 11.80 11.09 8 325353 173 79418854
Central nervous system viral infection 11.79 11.09 7 325354 119 79418908
Enterocolitis viral 11.79 11.09 11 325350 382 79418645
Hodgkin's disease 11.79 11.09 16 325345 844 79418183
Coordination abnormal 11.78 11.09 34 325327 17278 79401749
Autoimmune disorder 11.76 11.09 32 325329 16580 79402447
Scoliosis 11.76 11.09 8 325353 7456 79411571
Suspected product quality issue 11.75 11.09 10 325351 307 79418720
Cytomegalovirus oesophagitis 11.75 11.09 15 325346 745 79418282
Bacterial translocation 11.74 11.09 14 325347 648 79418379
Formication 11.73 11.09 3 325358 5020 79414007
Hyperleukocytosis 11.72 11.09 30 325331 2580 79416447
Antinuclear antibody positive 11.72 11.09 9 325352 7881 79411146
Central nervous system lesion 11.71 11.09 94 325267 13274 79405753
Bradypnoea 11.71 11.09 5 325356 6047 79412980
Metastases to abdominal cavity 11.70 11.09 14 325347 650 79418377
Tearfulness 11.69 11.09 5 325356 6040 79412987
Noctiphobia 11.65 11.09 4 325357 16 79419011
Beta 2 microglobulin decreased 11.65 11.09 4 325357 16 79419011
Product use issue 11.64 11.09 719 324642 209103 79209924
Pleocytosis 11.64 11.09 21 325340 1418 79417609
Cancer in remission 11.60 11.09 5 325356 41 79418986
Clonal haematopoiesis 11.60 11.09 5 325356 41 79418986
C-reactive protein 11.58 11.09 3 325358 4976 79414051
Splenic lesion 11.55 11.09 13 325348 565 79418462
Oesophageal infection 11.54 11.09 14 325347 660 79418367
Telangiectasia 11.53 11.09 21 325340 1428 79417599
Troponin I increased 11.52 11.09 44 325317 4694 79414333
Laryngopharyngitis 11.52 11.09 6 325355 78 79418949
Metastases to pancreas 11.51 11.09 13 325348 567 79418460
Allogenic bone marrow transplantation therapy 11.50 11.09 5 325356 42 79418985
Retroperitoneal mass 11.49 11.09 9 325352 245 79418782
Abdominal lymphadenopathy 11.47 11.09 20 325341 1314 79417713
Seizure 11.47 11.09 907 324454 187927 79231100
Platelet disorder 11.47 11.09 32 325329 2897 79416130
Colorectal cancer 11.46 11.09 11 325350 8636 79410391
Toxic erythema of chemotherapy 11.46 11.09 9 325352 246 79418781
KMT2A gene mutation 11.46 11.09 4 325357 17 79419010
Escherichia urinary tract infection 11.46 11.09 96 325265 13729 79405298
Thrombotic thrombocytopenic purpura 11.45 11.09 54 325307 6322 79412705
Follicle centre lymphoma, follicular grade I, II, III stage IV 11.45 11.09 3 325358 3 79419024
Hepatosplenic abscess 11.45 11.09 3 325358 3 79419024
Subretinal hyperreflective exudation 11.45 11.09 3 325358 3 79419024
CSF lymphocyte count abnormal 11.45 11.09 3 325358 3 79419024
Interferon gamma level increased 11.45 11.09 3 325358 3 79419024
Bladder telangiectasia 11.45 11.09 3 325358 3 79419024
Non-obstructive cardiomyopathy 11.45 11.09 3 325358 3 79419024
Breast prosthesis removal 11.45 11.09 3 325358 3 79419024
Spinal cord compression 11.45 11.09 54 325307 6323 79412704
Respiration abnormal 11.42 11.09 9 325352 7779 79411248
Tympanic membrane disorder 11.41 11.09 8 325353 183 79418844
Malignant pleural effusion 11.39 11.09 35 325326 3345 79415682
Depressive symptom 11.36 11.09 6 325355 6417 79412610
Peritonitis 11.35 11.09 169 325192 27867 79391160
Metastases to gastrointestinal tract 11.35 11.09 7 325354 128 79418899
Haptoglobin decreased 11.33 11.09 20 325341 1327 79417700
Stupor 11.33 11.09 7 325354 6865 79412162
Vitamin D deficiency 11.28 11.09 26 325335 14253 79404774
Respiratory tract ulceration 11.28 11.09 4 325357 18 79419009
Major depression 11.25 11.09 12 325349 8968 79410059
Pneumoperitoneum 11.24 11.09 33 325328 3075 79415952
Upper-airway cough syndrome 11.22 11.09 19 325342 11674 79407353
Visceral leishmaniasis 11.21 11.09 18 325343 1105 79417922
Abdominal abscess 11.13 11.09 58 325303 7069 79411958
Uterine enlargement 11.11 11.09 16 325345 892 79418135
Radiotherapy to brain 11.10 11.09 5 325356 46 79418981

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01AA01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ALKYLATING AGENTS
Nitrogen mustard analogues
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:50903 carcinogen
MeSH PA D000477 Alkylating Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018906 Antineoplastic Agents, Alkylating
MeSH PA D018501 Antirheumatic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009153 Mutagens
MeSH PA D019653 Myeloablative Agonists
MeSH PA D009676 Noxae

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Systemic AL amyloidosis indication 23132008
Acute lymphoid leukemia, disease indication 91857003 DOID:9952
Chronic lymphoid leukemia, disease indication 92814006
Chronic myeloid leukemia indication 92818009 DOID:8552
Histiocytic lymphoma indication 109988003
Multiple myeloma indication 109989006 DOID:9538
Hodgkin's disease indication 118599009
Malignant lymphoma indication 118600007 DOID:0060058
Burkitt's lymphoma indication 118617000
Mycosis fungoides indication 118618005
Mixedcell type lymphoma indication 188676008
Carcinoma of breast indication 254838004 DOID:3459
Acute myelogenous leukemia indication 359640008
Adenocarcinoma of the ovary indication 363443007 DOID:2394
Retinoblastoma indication 370967009 DOID:768
Acute monocytic leukemia indication 413441006
Neuroblastoma indication 432328008 DOID:769
Treatment prior to tumor-specific T-cell infusion therapy indication
Blood dyscrasias contraindication 34093004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.39 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Cytochrome P450 3A4 Enzyme IC50 5.68 WOMBAT-PK

External reference:

IDSource
4018114 VUID
N0000146452 NUI
D00287 KEGG_DRUG
3002 RXNORM
4018114 VANDF
C0010583 UMLSCUI
CHEBI:4026 CHEBI
CHEMBL88 ChEMBL_ID
CHEMBL1200796 ChEMBL_ID
DB00531 DRUGBANK_ID
D003520 MESH_DESCRIPTOR_UI
2907 PUBCHEM_CID
7154 IUPHAR_LIGAND_ID
8N3DW7272P UNII
31952 MMSL
4519 MMSL
d00036 MMSL
002631 NDDF
387420009 SNOMEDCT_US
74470007 SNOMEDCT_US
6055-19-2 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0054-0382 CAPSULE 25 mg ORAL NDA 27 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0054-0383 CAPSULE 50 mg ORAL NDA 27 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3233 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3244 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3255 INJECTION, POWDER, FOR SOLUTION 2 g ORAL ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-935 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-935 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-936 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-936 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-937 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-937 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-938 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-938 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-939 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-939 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-942 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-942 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-943 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-943 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-944 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-944 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-945 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-945 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-955 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-955 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-956 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-956 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-957 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-957 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-982 TABLET 25 mg ORAL NDA authorized generic 27 sections