cyclophosphamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
alkylating agents of the cyclophosphamide group 758 50-18-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cyclophosphamide
  • cyclophosphamid
  • cyclophosphamidum
  • cyclophosphan
  • cyclophosphane
  • cytophosphan
  • mitoxan
  • cyclophosphamide hydrate
  • endoxan
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
  • Molecular weight: 261.08
  • Formula: C7H15Cl2N2O2P
  • CLOGP: 0.80
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 41.57
  • ALOGS: -1.24
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 40 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 6.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 19.15 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 74 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.73 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.87 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 8 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.620 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 2.472 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 14.894 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 2.123 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 83.710 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 78.480 % High 1
herg hERG pIC50 3.509 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 0.910 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 4.074 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 78.830 % High 1
kinase-safety-class ACVR2B,CDK5,EIF2AK3,GRK2,PDK1,PDK2,PDK4,PRKDC 8
kinase-selectivity-class AXL,BRAF,CDK4,CHUK,GRK2,MAP2K6,TEK 7
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.132 High 1
mh-clint Mouse hepatocyte intrinsic clearance 15.136 High 1
mppb Mouse plasma protein binding (% unbound) 89.640 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 2.477 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 82.950 % High 1
rh-clint Rat hepatocyte intrinsic clearance 13.335 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 94.320 % High 1
rppb Rat plasma protein binding (% unbound) 84.330 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 893.305 uM High 1

Approvals:

DateAgencyCompanyOrphan
March 26, 2019 PMDA SHIONOGI & Co., Ltd.
Nov. 16, 1959 FDA BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 10076.32 11.46 6088 260945 152261 90209153
Neutropenia 4798.87 11.46 4494 262539 220410 90141004
Myelosuppression 4639.98 11.46 2524 264509 51067 90310347
Disease progression 3225.84 11.46 3072 263961 153543 90207871
Cytokine release syndrome 2190.33 11.46 1234 265799 26739 90334675
White blood cell count decreased 1942.27 11.46 2426 264607 164683 90196731
Acute myeloid leukaemia 1853.98 11.46 997 266036 19643 90341771
Mucosal inflammation 1724.05 11.46 1399 265634 56226 90305188
Bone marrow failure 1686.75 11.46 1098 265935 31123 90330291
Pancytopenia 1683.36 11.46 1920 265113 118343 90243071
Neutrophil count decreased 1598.88 11.46 1470 265563 70062 90291352
Agranulocytosis 1463.56 11.46 1038 265995 33964 90327450
Leukopenia 1419.50 11.46 1614 265419 99096 90262318
Thrombocytopenia 1384.74 11.46 2323 264710 206402 90155012
Myelodysplastic syndrome 1288.30 11.46 790 266243 20113 90341301
Haematotoxicity 1217.41 11.46 638 266395 11897 90349517
Disease recurrence 1189.45 11.46 944 266089 36709 90324705
Second primary malignancy 1125.64 11.46 569 266464 9809 90351605
Cytomegalovirus infection 1103.03 11.46 785 266248 25817 90335597
Cardiotoxicity 1095.59 11.46 576 266457 10813 90350601
Off label use 1091.66 11.46 6228 260805 1096024 89265390
Malignant neoplasm progression 1073.96 11.46 1445 265588 105425 90255989
Diffuse large B-cell lymphoma recurrent 1027.31 11.46 388 266645 3138 90358276
Joint swelling 967.76 11.46 161 266872 503139 89858275
Sepsis 965.14 11.46 1825 265208 177989 90183425
Pain 962.88 11.46 914 266119 995427 89365987
Pemphigus 933.51 11.46 5 267028 326859 90034555
Therapy partial responder 924.33 11.46 655 266378 21388 90340026
Pneumocystis jirovecii pneumonia 908.00 11.46 643 266390 20973 90340441
Cytopenia 904.14 11.46 591 266442 16858 90344556
Pyrexia 902.52 11.46 4090 262943 656395 89705019
Synovitis 879.55 11.46 19 267014 329733 90031681
Glossodynia 856.44 11.46 19 267014 321760 90039654
Cytomegalovirus infection reactivation 829.42 11.46 422 266611 7378 90354036
Febrile bone marrow aplasia 823.21 11.46 452 266581 9286 90352128
Acute graft versus host disease 821.63 11.46 375 266658 5093 90356321
Septic shock 806.03 11.46 1112 265921 83048 90278366
Abdominal discomfort 805.50 11.46 207 266826 477121 89884293
Systemic lupus erythematosus 799.42 11.46 73 266960 361823 89999591
Anaemia 775.71 11.46 2543 264490 350259 90011155
Ejection fraction decreased 775.55 11.46 633 266400 25620 90335794
Arthropathy 772.38 11.46 88 266945 366154 89995260
Swelling 764.45 11.46 153 266880 418905 89942509
Neuropathy peripheral 756.85 11.46 1408 265625 135562 90225852
Wound 755.60 11.46 32 267001 302948 90058466
Neoplasm progression 751.95 11.46 785 266248 43701 90317713
Hypogammaglobulinaemia 747.37 11.46 438 266595 10236 90351178
Venoocclusive liver disease 743.24 11.46 360 266673 5633 90355781
Cystitis haemorrhagic 701.35 11.46 337 266696 5176 90356238
Posterior reversible encephalopathy syndrome 700.96 11.46 558 266475 21781 90339633
Arthralgia 699.87 11.46 759 266274 777763 89583651
Multiple organ dysfunction syndrome 695.38 11.46 930 266103 67406 90294008
Rheumatoid arthritis 687.74 11.46 120 266913 362494 89998920
Nasopharyngitis 674.38 11.46 183 266850 406921 89954493
Product use in unapproved indication 662.75 11.46 2337 264696 333899 90027515
Chronic graft versus host disease 660.38 11.46 296 266737 3843 90357571
Contraindicated product administered 657.51 11.46 84 266949 320055 90041359
Peripheral swelling 647.18 11.46 206 266827 412900 89948514
Immune effector cell-associated neurotoxicity syndrome 645.32 11.46 323 266710 5445 90355969
Progressive multifocal leukoencephalopathy 644.37 11.46 460 266573 15195 90346219
Graft versus host disease 631.05 11.46 357 266676 7787 90353627
Neurotoxicity 628.61 11.46 515 266518 20952 90340462
Psoriatic arthropathy 625.78 11.46 9 267024 228326 90133088
Respiratory failure 623.93 11.46 1193 265840 117225 90244189
Helicobacter infection 621.45 11.46 9 267024 226841 90134573
Weight increased 617.39 11.46 230 266803 417697 89943717
Duodenal ulcer perforation 605.25 11.46 9 267024 221279 90140135
Cardiomyopathy 602.72 11.46 490 266543 19716 90341698
Hepatitis B reactivation 601.69 11.46 274 266759 3700 90357714
Cardiac failure 601.51 11.46 1123 265910 108373 90253041
Fall 595.89 11.46 340 266693 481470 89879944
Haemophagocytic lymphohistiocytosis 594.69 11.46 436 266597 15023 90346391
Acute graft versus host disease in skin 587.71 11.46 285 266748 4471 90356943
Pruritus 578.46 11.46 450 266583 541075 89820339
Drug hypersensitivity 577.84 11.46 324 266709 463285 89898129
Metastases to bone 576.93 11.46 528 266505 24977 90336437
Fibromyalgia 570.19 11.46 7 267026 206262 90155152
Therapeutic product effect decreased 567.10 11.46 74 266959 277497 90083917
Hepatic function abnormal 565.59 11.46 690 266343 45598 90315816
Platelet count decreased 562.44 11.46 1245 265788 135724 90225690
Irritable bowel syndrome 552.74 11.46 12 267021 207436 90153978
Neutropenic sepsis 541.48 11.46 440 266593 17690 90343724
Blood cholesterol increased 539.24 11.46 16 267017 207996 90153418
Folliculitis 528.72 11.46 16 267017 204337 90157077
Product dose omission issue 522.31 11.46 111 266922 291576 90069838
Musculoskeletal stiffness 502.84 11.46 127 266906 296405 90065009
Bronchopulmonary aspergillosis 494.78 11.46 346 266687 11052 90350362
Injury 484.77 11.46 23 267010 197326 90164088
Thrombotic microangiopathy 482.72 11.46 388 266645 15355 90346059
Tumour lysis syndrome 480.52 11.46 337 266696 10815 90350599
Premature menopause 478.77 11.46 171 266862 1158 90360256
Mobility decreased 472.95 11.46 84 266949 250650 90110764
Impaired healing 472.24 11.46 65 266968 234134 90127280
Sinusitis 464.27 11.46 215 266818 342873 90018541
Pericarditis 463.27 11.46 113 266920 270038 90091376
Rash 463.00 11.46 1040 265993 795060 89566354
Contusion 461.35 11.46 90 266943 251126 90110288
Metastases to liver 457.76 11.46 492 266541 28315 90333099
Headache 457.64 11.46 1183 265850 861563 89499851
Hepatic enzyme increased 449.42 11.46 252 266781 360484 90000930
Epstein-Barr virus infection 442.01 11.46 311 266722 10033 90351381
Hypersensitivity 436.44 11.46 418 266615 454259 89907155
Wheezing 429.45 11.46 89 266944 237991 90123423
Type 2 diabetes mellitus 425.27 11.46 50 266983 203194 90158220
Infusion related reaction 421.58 11.46 365 266668 416415 89944999
Osteoarthritis 417.46 11.46 45 266988 195685 90165729
Urticaria 412.34 11.46 203 266830 312531 90048883
Blister 395.76 11.46 129 266904 254869 90106545
Graft versus host disease in skin 368.07 11.46 194 266839 3659 90357755
Blood lactate dehydrogenase increased 365.58 11.46 416 266617 25516 90335898
Palmar-plantar erythrodysaesthesia syndrome 364.01 11.46 431 266602 27592 90333822
Ovarian failure 363.05 11.46 148 266885 1495 90359919
Asthma 359.41 11.46 132 266901 242028 90119386
Migraine 358.51 11.46 64 266969 190328 90171086
Anxiety 358.38 11.46 236 266797 309536 90051878
Left ventricular dysfunction 358.00 11.46 317 266716 14352 90347062
Injection site pain 355.38 11.46 46 266987 173653 90187761
Cytomegalovirus viraemia 347.40 11.46 238 266795 7348 90354066
Interstitial lung disease 346.15 11.46 723 266310 75682 90285732
BK virus infection 345.32 11.46 196 266837 4302 90357112
Lymphopenia 344.72 11.46 380 266653 22501 90338913
Post transplant lymphoproliferative disorder 344.48 11.46 229 266804 6720 90354694
Pain in extremity 342.51 11.46 498 266535 450031 89911383
Congestive cardiomyopathy 342.17 11.46 233 266800 7121 90354293
Completed suicide 340.45 11.46 22 267011 145036 90216378
Metastases to lung 334.54 11.46 317 266716 15674 90345740
Hepatitis B 331.08 11.46 191 266842 4328 90357086
Pleural effusion 330.61 11.46 897 266136 111094 90250320
Discomfort 326.90 11.46 202 266831 274133 90087281
Polyneuropathy 324.42 11.46 340 266693 19001 90342413
Bursitis 324.38 11.46 15 267018 131639 90229775
Acute lymphocytic leukaemia recurrent 324.04 11.46 159 266874 2562 90358852
Malaise 321.35 11.46 789 266244 585197 89776217
Cardiac dysfunction 320.77 11.46 173 266860 3424 90357990
Dizziness 320.37 11.46 797 266236 588487 89772927
Psoriasis 317.53 11.46 33 267000 147721 90213693
Diffuse large B-cell lymphoma 317.18 11.46 237 266796 8408 90353006
Aspergillus infection 311.29 11.46 257 266776 10566 90350848
Bone pain 305.01 11.46 607 266426 61376 90300038
Neutropenic colitis 303.24 11.46 175 266858 3968 90357446
Human herpesvirus 6 infection 303.08 11.46 164 266869 3268 90358146
Drug ineffective for unapproved indication 299.97 11.46 629 266404 66015 90295399
Breast cancer recurrent 298.82 11.46 192 266841 5311 90356103
Fatigue 297.33 11.46 2088 264945 1151935 89209479
Depression 296.86 11.46 269 266764 300332 90061082
Graft versus host disease in gastrointestinal tract 296.52 11.46 176 266857 4212 90357202
Staphylococcal bacteraemia 294.84 11.46 214 266819 7255 90354159
Drug intolerance 292.43 11.46 546 266487 447045 89914369
Joint range of motion decreased 292.24 11.46 30 267003 135613 90225801
Bacteraemia 291.33 11.46 344 266689 21956 90339458
Viral haemorrhagic cystitis 291.11 11.46 123 266910 1370 90360044
Sleep disorder 290.37 11.46 110 266923 197920 90163494
Aplasia 287.91 11.46 167 266866 3824 90357590
Muscle spasms 285.76 11.46 196 266837 251687 90109727
Insomnia 285.73 11.46 337 266696 333137 90028277
Acute promyelocytic leukaemia 285.20 11.46 112 266921 1017 90360397
Lymphocyte count decreased 275.48 11.46 422 266611 34628 90326786
Facet joint syndrome 273.34 11.46 3 267030 98386 90263028
Adenovirus infection 272.81 11.46 170 266863 4452 90356962
Diffuse large B-cell lymphoma refractory 269.02 11.46 123 266910 1677 90359737
Overdose 264.38 11.46 69 266964 157640 90203774
Venoocclusive disease 261.51 11.46 133 266900 2322 90359092
Dry mouth 260.39 11.46 108 266925 183951 90177463
C-reactive protein abnormal 260.02 11.46 34 266999 127395 90234019
Prescribed overdose 258.58 11.46 6 267027 97619 90263795
Road traffic accident 253.50 11.46 16 267017 107610 90253804
Confusional state 252.30 11.46 471 266562 385734 89975680
Lower respiratory tract infection 250.21 11.46 222 266811 250437 90110977
Pneumonitis 248.61 11.46 458 266575 43712 90317702
Breast cancer metastatic 248.43 11.46 263 266770 14869 90346545
Metastases to central nervous system 246.56 11.46 281 266752 17261 90344153
Abdominal pain upper 246.55 11.46 374 266659 332300 90029114
Granulocyte count decreased 244.32 11.46 127 266906 2325 90359089
Drug resistance 241.27 11.46 368 266665 30081 90331333
Intentional overdose 240.27 11.46 8 267025 93826 90267588
Gait inability 239.98 11.46 67 266966 146389 90215025
Metastases to lymph nodes 239.35 11.46 229 266804 11460 90349954
Sciatica 239.00 11.46 15 267018 101367 90260047
Arthritis 236.96 11.46 98 266935 167217 90194197
Neoplasm recurrence 236.77 11.46 137 266896 3122 90358292
Cytomegalovirus chorioretinitis 234.48 11.46 123 266910 2296 90359118
Organising pneumonia 232.39 11.46 187 266846 7410 90354004
Gait disturbance 230.94 11.46 256 266777 260240 90101174
Grip strength decreased 229.84 11.46 10 267023 92566 90268848
Breast cancer stage III 228.41 11.46 4 267029 84443 90276971
Acute lymphocytic leukaemia 226.47 11.46 127 266906 2721 90358693
Varicella zoster virus infection 224.80 11.46 141 266892 3736 90357678
Peripheral sensory neuropathy 223.94 11.46 199 266834 9051 90352363
Lower limb fracture 222.21 11.46 6 267027 85007 90276407
Enterococcal infection 216.54 11.46 202 266831 9789 90351625
Memory impairment 216.42 11.46 159 266874 197085 90164329
Loss of personal independence in daily activities 212.57 11.46 68 266965 136037 90225377
Musculoskeletal pain 212.51 11.46 120 266913 171131 90190283
Feeling abnormal 210.69 11.46 115 266918 167120 90194294
JC virus infection 210.13 11.46 119 266914 2600 90358814
Acute respiratory distress syndrome 206.85 11.46 332 266701 28354 90333060
Blood pressure increased 206.18 11.46 167 266866 197050 90164364
Dyspepsia 201.97 11.46 172 266861 197988 90163426
Hypercholesterolaemia 200.92 11.46 29 267004 100863 90260551
Wound infection 199.74 11.46 36 266997 106366 90255048
Injection site reaction 196.69 11.46 21 267012 92059 90269355
Systemic candida 195.55 11.46 142 266891 4817 90356597
Product quality issue 195.51 11.46 9 267024 79316 90282098
Mucormycosis 194.44 11.46 128 266905 3693 90357721
Lymphadenopathy 194.39 11.46 422 266611 45353 90316061
Granulocytopenia 193.75 11.46 157 266876 6284 90355130
Hypoaesthesia 188.97 11.46 402 266631 313808 90047606
Injection site erythema 187.80 11.46 32 267001 98470 90262944
Ill-defined disorder 187.80 11.46 161 266872 184730 90176684
Metastasis 187.59 11.46 151 266882 5986 90355428
Hospitalisation 184.68 11.46 73 266960 128027 90233387
Escherichia bacteraemia 183.61 11.46 145 266888 5590 90355824
Computerised tomogram thorax abnormal 182.27 11.46 99 266934 1988 90359426
Peripheral venous disease 182.21 11.46 18 267015 83903 90277511
Myocarditis 182.03 11.46 214 266819 13592 90347822
B-cell lymphoma recurrent 179.66 11.46 65 266968 459 90360955
Pulmonary alveolar haemorrhage 177.89 11.46 145 266888 5853 90355561
Bone marrow disorder 177.64 11.46 111 266922 2921 90358493
Pneumonia fungal 175.68 11.46 154 266879 6877 90354537
Maternal exposure before pregnancy 175.46 11.46 190 266843 11023 90350391
Prescribed underdose 174.16 11.46 12 267021 75007 90286407
Herpes simplex 172.57 11.46 180 266853 10001 90351413
Amnesia 171.59 11.46 53 266980 108452 90252962
Intentional product misuse 168.87 11.46 30 267003 89574 90271840
Immune-mediated adrenal insuficiency 168.22 11.46 76 266957 1006 90360408
Night sweats 167.41 11.46 85 266948 128681 90232733
Clostridium difficile colitis 167.04 11.46 290 266743 26416 90334998
Hypertension 166.75 11.46 737 266296 456795 89904619
Gastrooesophageal reflux disease 166.31 11.46 147 266886 166190 90195224
Pericardial effusion 166.13 11.46 348 266685 36485 90324929
Acute graft versus host disease in intestine 165.94 11.46 93 266940 1990 90359424
Central nervous system lymphoma 163.98 11.46 92 266941 1973 90359441
Klebsiella infection 163.79 11.46 176 266857 10121 90351293
Inappropriate schedule of product administration 162.98 11.46 122 266911 149811 90211603
Staphylococcal sepsis 162.83 11.46 168 266865 9215 90352199
Epstein-Barr virus associated lymphoproliferative disorder 162.24 11.46 100 266933 2567 90358847
Lymphoma 160.15 11.46 199 266834 13392 90348022
Ascites 159.87 11.46 401 266632 47339 90314075
Product use issue 158.83 11.46 473 266560 329446 90031968
Drug abuse 156.44 11.46 27 267006 82320 90279094
Bronchitis 155.49 11.46 133 266900 152794 90208620
Pneumatosis intestinalis 155.41 11.46 107 266926 3330 90358084
Obesity 153.94 11.46 59 266974 105448 90255966
Hypoxia 153.28 11.46 516 266517 71883 90289531
Infection reactivation 152.88 11.46 86 266947 1854 90359560
Stem cell transplant 152.38 11.46 89 266944 2065 90359349
Blood follicle stimulating hormone increased 150.91 11.46 45 266988 154 90361260
Colony stimulating factor therapy 150.64 11.46 54 266979 370 90361044
Foot deformity 149.55 11.46 6 267027 59645 90301769
Adverse drug reaction 148.80 11.46 79 266954 116622 90244792
Hypoalbuminaemia 147.49 11.46 207 266826 15690 90345724
Maternal exposure during pregnancy 146.15 11.46 556 266477 359507 90001907
Hepatic failure 146.14 11.46 346 266687 39382 90322032
Transplant failure 143.65 11.46 83 266950 1886 90359528
Joint stiffness 143.07 11.46 28 267005 78014 90283400
Dislocation of vertebra 142.48 11.46 5 267028 55963 90305451
Frequent bowel movements 141.82 11.46 6 267027 56929 90304485
Enterococcal bacteraemia 141.38 11.46 83 266950 1945 90359469
Injection site swelling 140.59 11.46 9 267024 59830 90301584
Weight decreased 140.17 11.46 609 266424 379301 89982113
Fungaemia 139.14 11.46 99 266934 3251 90358163
Capillary leak syndrome 139.12 11.46 92 266941 2675 90358739
Pseudomonas infection 138.56 11.46 194 266839 14671 90346743
Exostosis 137.93 11.46 4 267029 53130 90308284
Blepharospasm 137.59 11.46 6 267027 55439 90305975
Medication error 136.30 11.46 40 266993 84612 90276802
Adverse event 136.26 11.46 89 266944 117329 90244085
Therapy responder 135.70 11.46 47 266986 287 90361127
Chronic graft versus host disease in skin 134.48 11.46 68 266965 1172 90360242
Suicide attempt 132.16 11.46 30 267003 75369 90286045
Somnolence 132.00 11.46 260 266773 208824 90152590
Live birth 131.80 11.46 35 266998 79072 90282342
Pulmonary haemorrhage 131.06 11.46 139 266894 7874 90353540
Injection site pruritus 129.82 11.46 7 267026 53827 90307587
Systemic mycosis 129.25 11.46 71 266962 1459 90359955
Ear infection 127.98 11.46 25 267008 69750 90291664
Leukaemia recurrent 126.48 11.46 69 266964 1398 90360016
Incorrect dose administered 125.80 11.46 38 266995 78892 90282522
Leukoencephalopathy 124.30 11.46 108 266925 4765 90356649
Osteonecrosis 123.11 11.46 252 266781 25989 90335425
Bacterial sepsis 122.74 11.46 108 266925 4847 90356567
Hip arthroplasty 122.71 11.46 36 266997 76172 90285242
Inflammation 122.58 11.46 211 266822 178381 90183033
Red blood cell sedimentation rate increased 122.48 11.46 45 266988 82550 90278864
Secondary immunodeficiency 122.46 11.46 77 266956 2049 90359365
Gene mutation 122.33 11.46 77 266956 2053 90359361
Autoimmune disorder 122.21 11.46 37 266996 76707 90284707
Neutropenic infection 120.78 11.46 72 266961 1737 90359677
Aplastic anaemia 120.46 11.46 171 266862 13098 90348316
Primary hypogonadism 120.36 11.46 38 266995 165 90361249
Pneumonia cytomegaloviral 120.22 11.46 88 266945 3023 90358391
Chemotherapy 120.12 11.46 72 266961 1755 90359659
Venous thrombosis 120.09 11.46 112 266921 5425 90355989
Rhinovirus infection 118.64 11.46 115 266918 5848 90355566
Osteolysis 118.50 11.46 92 266941 3458 90357956
Hyperpyrexia 118.39 11.46 104 266929 4657 90356757
Pneumomediastinum 118.10 11.46 74 266959 1957 90359457
Stress 117.94 11.46 46 266987 81349 90280065
Subclavian vein thrombosis 117.80 11.46 75 266958 2041 90359373
Illness 117.66 11.46 47 266986 81922 90279492
Disseminated intravascular coagulation 117.01 11.46 220 266813 21318 90340096
Injection site bruising 116.81 11.46 10 267023 52297 90309117
Condition aggravated 116.54 11.46 1157 265876 594388 89767026
Back injury 115.84 11.46 5 267028 46617 90314797
COVID-19 pneumonia 114.48 11.46 198 266835 17979 90343435
Pneumocystis jirovecii infection 113.74 11.46 71 266962 1865 90359549
Splenomegaly 112.12 11.46 163 266870 12761 90348653
Cytokine increased 111.84 11.46 31 267002 75 90361339
Myelopathy 110.09 11.46 87 266946 3357 90358057
Lupus-like syndrome 110.01 11.46 9 267024 48837 90312577
Recurrent cancer 109.88 11.46 76 266957 2383 90359031
Aortitis 109.52 11.46 61 266972 1289 90360125
Lupus nephritis 109.18 11.46 100 266933 4732 90356682
Acute graft versus host disease in liver 107.79 11.46 51 266982 755 90360659
Epstein-Barr virus infection reactivation 106.30 11.46 64 266969 1573 90359841
Staphylococcal infection 104.97 11.46 348 266685 48091 90313323
Amenorrhoea 104.85 11.46 150 266883 11572 90349842
Cytomegalovirus test positive 104.79 11.46 86 266947 3505 90357909
COVID-19 104.65 11.46 853 266180 167990 90193424
Neck pain 104.25 11.46 109 266924 113854 90247560
Drug effective for unapproved indication 103.17 11.46 122 266911 7796 90353618
Pseudomonal sepsis 103.04 11.46 92 266941 4210 90357204
Drug interaction 102.61 11.46 442 266591 276011 90085403
Plasma cell myeloma recurrent 102.43 11.46 91 266942 4137 90357277
Myeloid leukaemia 102 11.46 43 266990 476 90360938
Klebsiella bacteraemia 101.70 11.46 74 266959 2518 90358896
Death 101.52 11.46 1899 265134 454652 89906762
Joint dislocation 101 11.46 8 267025 44574 90316840
Bacterial infection 100.51 11.46 217 266816 23227 90338187
Plasma cell myeloma refractory 100.38 11.46 53 266980 1003 90360411
Proteinuria 100.33 11.46 216 266817 23075 90338339
Anti-Muellerian hormone level decreased 100.13 11.46 29 267004 87 90361327
Ovarian atrophy 100.09 11.46 28 267005 71 90361343
Acute pulmonary oedema 99.86 11.46 132 266901 9448 90351966
Multiple sclerosis relapse 99.67 11.46 17 267016 52288 90309126
Enterobacter infection 99.67 11.46 73 266960 2510 90358904
Alopecia 99.23 11.46 956 266077 494115 89867299
Disability 99.19 11.46 5 267028 40740 90320674
Refractory anaemia with an excess of blasts 98.21 11.46 40 266993 403 90361011
Laryngitis 97.82 11.46 16 267017 50737 90310677
Radiotherapy 97.69 11.46 50 266983 885 90360529
Pseudocirrhosis 97.24 11.46 50 266983 894 90360520
Cytomegalovirus colitis 96.53 11.46 80 266953 3306 90358108
Sedation 95.54 11.46 14 267019 48157 90313257
Colitis 95.41 11.46 434 266599 69508 90291906
Biopsy lung abnormal 95.25 11.46 30 267003 129 90361285
Bone erosion 95.15 11.46 20 267013 53001 90308413
Pulmonary embolism 94.49 11.46 685 266348 130135 90231279
Neutrophil count abnormal 94.39 11.46 86 266947 4042 90357372
Brain abscess 91.97 11.46 72 266961 2740 90358674
Gastrointestinal toxicity 91.90 11.46 126 266907 9341 90352073
Nasal congestion 91.75 11.46 67 266966 83347 90278067
Immune-mediated hypophysitis 91.51 11.46 40 266993 487 90360927
Blood pressure systolic increased 91.34 11.46 29 267004 58316 90303098
Engraftment syndrome 91.25 11.46 44 266989 681 90360733
Sleep disorder due to a general medical condition 91.09 11.46 12 267021 44726 90316688
Incorrect route of product administration 91.05 11.46 19 267014 50607 90310807
Balance disorder 90.89 11.46 91 266942 96989 90264425
Hepatitis E 90.33 11.46 61 266972 1838 90359576
Fluid retention 90.27 11.46 76 266957 88015 90273399
Intestinal perforation 89.78 11.46 153 266880 13728 90347686
Alveolar proteinosis 89.08 11.46 46 266987 830 90360584
Renal failure 88.95 11.46 676 266357 130331 90231083
Acquired haemophilia 88.63 11.46 49 266984 1020 90360394
Heart rate decreased 88.51 11.46 24 267009 53481 90307933
Oedema 88.01 11.46 299 266734 199996 90161418
Candida infection 87.93 11.46 260 266773 33797 90327617
Skin toxicity 87.58 11.46 104 266929 6675 90354739
Mantle cell lymphoma recurrent 87.58 11.46 36 266997 372 90361042
Alpha haemolytic streptococcal infection 87.41 11.46 58 266975 1696 90359718
White blood cell count abnormal 87.01 11.46 109 266924 7395 90354019
Retinitis 86.85 11.46 7 267026 38451 90322963
B-cell aplasia 86.79 11.46 32 267001 240 90361174
Inappropriate antidiuretic hormone secretion 86.45 11.46 183 266850 19322 90342092
Metastases to pleura 86.27 11.46 61 266972 1983 90359431
Macular degeneration 85.50 11.46 7 267026 37963 90323451
Onychomadesis 85.37 11.46 16 267017 45982 90315432
Disseminated mucormycosis 85.29 11.46 41 266992 630 90360784
Strongyloidiasis 84.78 11.46 55 266978 1547 90359867
Ventricular hypokinesia 84.44 11.46 91 266942 5250 90356164
Hepatotoxicity 84.34 11.46 312 266721 45530 90315884
Pre-existing disease 84.30 11.46 29 267004 173 90361241
Breast cancer stage II 83.95 11.46 5 267028 35329 90326085
Ventricular dysfunction 83.88 11.46 77 266956 3654 90357760
Therapy interrupted 83.79 11.46 22 267011 50086 90311328
Metastases to skin 83.75 11.46 61 266972 2079 90359335
Liver function test increased 83.58 11.46 76 266957 84779 90276635
Chronic myelomonocytic leukaemia 83.54 11.46 35 266998 381 90361033
Lung infiltration 82.89 11.46 156 266877 15126 90346288
Pneumonia bacterial 82.75 11.46 141 266892 12649 90348765
Smooth muscle cell neoplasm 82.30 11.46 51 266982 1322 90360092
Suicidal ideation 81.65 11.46 59 266974 73796 90287618
Haemoglobin decreased 81.62 11.46 782 266251 161174 90200240
Visual impairment 81.46 11.46 167 266866 132198 90229216
Transaminases increased 81.30 11.46 268 266765 36924 90324490
Hypokalaemia 80.47 11.46 661 266372 130455 90230959
Plasma cell myeloma 80.31 11.46 284 266749 40544 90320870
Colitis ulcerative 79.49 11.46 39 266994 60227 90301187
Toxic cardiomyopathy 79.49 11.46 32 267001 312 90361102
Gastrointestinal necrosis 79.30 11.46 70 266963 3155 90358259
B-cell type acute leukaemia 79.22 11.46 38 266995 581 90360833
Walking aid user 78.70 11.46 7 267026 35499 90325915
Blood pressure fluctuation 78.65 11.46 28 267005 52385 90309029
Haematuria 78.39 11.46 254 266779 34683 90326731
Nocardiosis 78.05 11.46 63 266970 2507 90358907
Meningitis cryptococcal 78.05 11.46 55 266978 1778 90359636
Encephalopathy 77.95 11.46 307 266726 46137 90315277
Dyspnoea 77.88 11.46 1989 265044 878966 89482448
Acute myelomonocytic leukaemia 77.60 11.46 28 267005 196 90361218
Embolism 77.10 11.46 116 266917 9365 90352049
Cystitis viral 77.04 11.46 29 267004 232 90361182
Pneumonia 76.76 11.46 2440 264593 635619 89725795
Lennox-Gastaut syndrome 76.14 11.46 30 267003 275 90361139
Leukaemia cutis 75.68 11.46 25 267008 129 90361285
Blood luteinising hormone increased 75.51 11.46 24 267009 107 90361307
Blood glucose increased 75.47 11.46 102 266931 95144 90266270
Mitral valve incompetence 75.19 11.46 189 266844 22335 90339079
Respiratory syncytial virus infection 75.15 11.46 121 266912 10359 90351055
Nephropathy toxic 74.46 11.46 134 266899 12554 90348860
Feeling hot 74.32 11.46 72 266961 77936 90283478
Delirium 73.70 11.46 121 266912 104238 90257176
Viraemia 73.21 11.46 51 266982 1618 90359796
Vasogenic cerebral oedema 72.50 11.46 46 266987 1244 90360170
Atelectasis 72.45 11.46 196 266837 24213 90337201
Hypertransaminasaemia 71.91 11.46 150 266883 15675 90345739
Osteosarcoma 71.85 11.46 24 267009 129 90361285
Upper respiratory fungal infection 71.69 11.46 26 267007 185 90361229
Device related infection 71.53 11.46 202 266831 25584 90335830
International normalised ratio increased 71.48 11.46 25 267008 47291 90314123
Premature delivery 71.46 11.46 264 266769 38498 90322916
Joint injury 70.91 11.46 7 267026 32657 90328757
Therapy non-responder 70.83 11.46 664 266369 136040 90225374
Chronic obstructive pulmonary disease 70.50 11.46 68 266965 73761 90287653
Injection site haemorrhage 70.47 11.46 3 267030 28315 90333099
Peripheral motor neuropathy 69.96 11.46 53 266980 1920 90359494
Onychomycosis 69.37 11.46 13 267020 37363 90324051
Device related thrombosis 69.34 11.46 54 266979 2039 90359375
Pregnancy 69.34 11.46 49 266984 61998 90299416
Polyomavirus viraemia 69.17 11.46 45 266988 1272 90360142
Nephrolithiasis 69.05 11.46 29 267004 49056 90312358
Hallucination 68.70 11.46 56 266977 65903 90295511
Encephalitis 68.45 11.46 120 266913 11014 90350400
Systemic scleroderma 68.41 11.46 48 266985 1541 90359873
Invasive ductal breast carcinoma 68.40 11.46 99 266934 7719 90353695
Chronic lymphocytic leukaemia recurrent 68.36 11.46 30 267003 369 90361045
Acute leukaemia 68.10 11.46 43 266990 1153 90360261
Acute myeloid leukaemia recurrent 67.99 11.46 53 266980 2004 90359410
Parainfluenzae virus infection 67.25 11.46 60 266973 2743 90358671
Lung consolidation 67.11 11.46 77 266956 4763 90356651
Dysplasia 66.84 11.46 45 266988 1349 90360065
Alopecia areata 66.78 11.46 52 266981 1963 90359451
Primary amyloidosis 66.55 11.46 21 267012 91 90361323
Computerised tomogram thorax 66.49 11.46 32 267001 493 90360921
Blood stem cell transplant failure 66.41 11.46 25 267008 200 90361214
Eye pruritus 66.34 11.46 5 267028 29022 90332392
Lymphoma transformation 66.09 11.46 25 267008 203 90361211
B precursor type acute leukaemia 66.02 11.46 26 267007 238 90361176
Chronic myeloid leukaemia 65.86 11.46 58 266975 2606 90358808
Nephrotic syndrome 65.77 11.46 94 266939 7245 90354169
Klebsiella sepsis 65.72 11.46 49 266984 1732 90359682
Hepatic cirrhosis 65.51 11.46 54 266979 63199 90298215
Procedural pain 65.46 11.46 10 267023 33350 90328064
Alveolitis 65.31 11.46 61 266972 2960 90358454
Rash pruritic 65.18 11.46 88 266945 82126 90279288
Myeloproliferative neoplasm 65.13 11.46 34 266999 628 90360786
Escherichia sepsis 65.09 11.46 83 266950 5733 90355681
Humoral immune defect 65.07 11.46 29 267004 371 90361043
Liver injury 64.92 11.46 270 266763 170297 90191117
Immune-mediated hypothyroidism 64.61 11.46 46 266987 1512 90359902
Pneumothorax 64.16 11.46 161 266872 19006 90342408
Rectal haemorrhage 64.16 11.46 90 266943 82654 90278760
Obliterative bronchiolitis 63.55 11.46 57 266976 2624 90358790
Alveolar soft part sarcoma 63.32 11.46 20 267013 87 90361327
Metastases to meninges 63.24 11.46 66 266967 3669 90357745
Encephalitis viral 63.15 11.46 49 266984 1840 90359574
Cardiomyopathy acute 63.14 11.46 26 267007 270 90361144
Angioedema 62.83 11.46 59 266974 64817 90296597
Oedema peripheral 62.82 11.46 473 266560 257442 90103972
Acute monocytic leukaemia 62.49 11.46 22 267011 142 90361272
Refractory cytopenia with multilineage dysplasia 61.94 11.46 21 267012 119 90361295
Metastases to chest wall 61.87 11.46 33 267000 638 90360776
Sinus disorder 61.80 11.46 13 267020 34434 90326980
Renal tubular injury 61.52 11.46 41 266992 1208 90360206
Radiation skin injury 61.26 11.46 39 266994 1061 90360353
Underdose 61.23 11.46 42 266991 53975 90307439
N-terminal prohormone brain natriuretic peptide increased 60.58 11.46 58 266975 2904 90358510
Complications of bone marrow transplant 60.54 11.46 29 267004 442 90360972
Oesophageal candidiasis 60.51 11.46 87 266946 6742 90354672
Treatment failure 60.34 11.46 588 266445 303340 90058074
Left ventricular failure 60.31 11.46 86 266947 6614 90354800
Swollen tongue 60.22 11.46 30 267003 45926 90315488
Jugular vein thrombosis 60.13 11.46 63 266970 3518 90357896
Muscular weakness 59.83 11.46 360 266673 206306 90155108
Peripheral sensorimotor neuropathy 59.72 11.46 49 266984 1996 90359418
Acne 59.61 11.46 7 267026 28500 90332914
Ototoxicity 59.34 11.46 48 266985 1916 90359498
Ileus paralytic 59.18 11.46 74 266959 5011 90356403
Hyperhidrosis 58.83 11.46 205 266828 136100 90225314
Idiopathic pneumonia syndrome 58.67 11.46 28 267005 423 90360991
Metastases to bone marrow 58.65 11.46 31 267002 588 90360826
Invasive lobular breast carcinoma 58.60 11.46 37 266996 992 90360422
Device dislocation 58.32 11.46 11 267022 31471 90329943
Chest pain 58.28 11.46 631 266402 319014 90042400
Periarticular thenar erythema with onycholysis 58.21 11.46 17 267016 53 90361361
Muscle spasticity 58.13 11.46 16 267017 35306 90326108
Bronchial polyp 57.99 11.46 18 267015 73 90361341
Multifocal micronodular pneumocyte hyperplasia 57.99 11.46 18 267015 73 90361341
Clostridium difficile infection 57.96 11.46 236 266797 36009 90325405
Disease susceptibility 57.72 11.46 24 267009 256 90361158
Hyperbilirubinaemia 57.47 11.46 127 266906 13809 90347605
Human bocavirus infection 57.46 11.46 28 267005 444 90360970
Taste disorder 57.25 11.46 58 266975 61488 90299926
Leukaemia 57.07 11.46 72 266961 4920 90356494
Troponin increased 57.01 11.46 123 266910 13158 90348256
Hyperferritinaemia 56.96 11.46 26 267007 353 90361061
Encephalitis cytomegalovirus 56.88 11.46 32 267001 690 90360724
Dry skin 56.87 11.46 108 266925 87965 90273449
T-cell type acute leukaemia 56.82 11.46 20 267013 129 90361285
Dermatitis atopic 56.75 11.46 3 267030 23469 90337945
Osteonecrosis of jaw 56.61 11.46 247 266786 38856 90322558
Retinitis viral 56.51 11.46 24 267009 271 90361143
Human polyomavirus infection 56.04 11.46 27 267006 417 90360997
Emotional distress 56.02 11.46 19 267014 36643 90324771
Necrotising fasciitis 55.96 11.46 63 266970 3817 90357597
Thyroiditis 55.81 11.46 61 266972 3576 90357838
Flatulence 55.73 11.46 26 267007 41341 90320073
Epstein-Barr viraemia 55.49 11.46 41 266992 1429 90359985
Unevaluable event 55.36 11.46 48 266985 54800 90306614
Hypoglycaemia 55.13 11.46 75 266958 69773 90291641
Lymphangiosis carcinomatosa 55.09 11.46 43 266990 1629 90359785
Extravasation 54.95 11.46 55 266978 2909 90358505
Hepatocellular injury 54.87 11.46 199 266834 28759 90332655
Toxoplasmosis 54.73 11.46 44 266989 1741 90359673
Fusarium infection 54.46 11.46 36 266997 1046 90360368
Enterocolitis 54.33 11.46 105 266928 10385 90351029
Troponin I increased 54.10 11.46 51 266982 2504 90358910
Necrosis 53.93 11.46 81 266952 6529 90354885
Cerebrovascular accident 53.85 11.46 185 266848 123348 90238066
Left ventricular dilatation 53.82 11.46 30 267003 635 90360779
Adverse reaction 53.74 11.46 11 267022 29701 90331713
Ulcer haemorrhage 53.73 11.46 7 267026 26314 90335100
Pleuroparenchymal fibroelastosis 53.64 11.46 21 267012 189 90361225
Deep vein thrombosis 53.60 11.46 457 266576 91163 90270251
Generalised oedema 53.58 11.46 150 266883 18903 90342511
Guillain-Barre syndrome 53.49 11.46 67 266966 4545 90356869
Hepatomegaly 53.34 11.46 120 266913 13206 90348208
Drug withdrawal syndrome 53.28 11.46 10 267023 28713 90332701
Follicular lymphoma 53.03 11.46 25 267008 367 90361047
Cardiac failure acute 52.96 11.46 112 266921 11817 90349597
Anti-neutrophil cytoplasmic antibody positive vasculitis 52.81 11.46 62 266971 3931 90357483
Eczema 52.48 11.46 47 266986 52823 90308591
Portal hypertension 52.47 11.46 67 266966 4634 90356780
Haematochezia 52.17 11.46 80 266953 70833 90290581
Streptococcal bacteraemia 52.10 11.46 47 266986 2180 90359234
Plasmacytoma 52.10 11.46 52 266981 2741 90358673
Sinus congestion 52.06 11.46 9 267024 27415 90333999
Back pain 52.03 11.46 641 266392 316534 90044880
Ear pain 51.85 11.46 56 266977 57646 90303768
Human herpesvirus 6 encephalitis 51.78 11.46 25 267008 388 90361026
Diffuse alveolar damage 51.67 11.46 35 266998 1060 90360354
Gastrosplenic fistula 51.52 11.46 16 267017 65 90361349
Osteoporosis 51.14 11.46 132 266901 96399 90265015
Vasculitis 50.92 11.46 165 266868 22528 90338886
Eye swelling 50.88 11.46 12 267021 29374 90332040
Heart rate increased 50.63 11.46 167 266866 112735 90248679
Microangiopathic haemolytic anaemia 50.56 11.46 31 267002 788 90360626
Leukocytosis 50.52 11.46 203 266830 30787 90330627
Injection site rash 50.39 11.46 6 267027 24167 90337247
Respiratory tract congestion 49.88 11.46 10 267023 27400 90334014
Nervousness 49.74 11.46 19 267014 34037 90327377
Abdominal compartment syndrome 49.27 11.46 30 267003 753 90360661
Dry eye 49.04 11.46 59 266974 57872 90303542
Soft tissue infection 48.70 11.46 51 266982 2846 90358568
Escherichia infection 48.55 11.46 129 266904 15766 90345648
5q minus syndrome 48.29 11.46 20 267013 211 90361203
Palpitations 48.04 11.46 223 266810 136505 90224909
Administration site extravasation 48.00 11.46 35 266998 1195 90360219
Cardiogenic shock 47.94 11.46 170 266863 24298 90337116
Lip swelling 47.94 11.46 27 267006 38583 90322831
Blood disorder 47.94 11.46 84 266949 7706 90353708
Eye irritation 47.92 11.46 20 267013 33958 90327456
Immune thrombocytopenia 47.86 11.46 115 266918 13211 90348203
Geotrichum infection 47.71 11.46 27 267006 589 90360825
Throat irritation 47.49 11.46 44 266989 48651 90312763
Hydrocephalus 47.35 11.46 73 266960 6021 90355393
Seasonal allergy 47.18 11.46 6 267027 22977 90338437
Bone lesion 47.08 11.46 75 266958 6362 90355052
Recall phenomenon 47.03 11.46 30 267003 819 90360595
Food allergy 46.99 11.46 9 267024 25469 90335945
Human herpesvirus 6 infection reactivation 46.99 11.46 27 267006 607 90360807
Therapeutic response shortened 46.91 11.46 6 267027 22873 90338541
Glioblastoma multiforme 46.70 11.46 31 267002 907 90360507
Bone marrow transplant 46.68 11.46 30 267003 830 90360584
Gastric disorder 46.52 11.46 20 267013 33364 90328050
Immune-mediated cytopenia 46.43 11.46 16 267017 96 90361318
Premature baby 46.39 11.46 171 266862 24906 90336508
Pulmonary toxicity 46.34 11.46 104 266929 11427 90349987
Angiocentric lymphoma 46.33 11.46 28 267005 693 90360721
Carbohydrate antigen 15-3 increased 46.25 11.46 42 266991 1965 90359449
Quadriplegia 46.23 11.46 44 266989 2187 90359227
Enterococcal sepsis 45.69 11.46 38 266995 1578 90359836
Malignant transformation 45.59 11.46 26 267007 576 90360838
Product prescribing error 45.41 11.46 16 267017 30129 90331285
Lupus vasculitis 45.34 11.46 26 267007 582 90360832
Burning sensation 45.33 11.46 73 266960 63379 90298035
Plasma cell leukaemia 45.30 11.46 33 267000 1125 90360289
Acute hepatitis B 45.25 11.46 22 267011 347 90361067
Blood immunoglobulin G decreased 45.25 11.46 54 266979 3484 90357930
Pulmonary veno-occlusive disease 45.23 11.46 37 266996 1501 90359913
Refractory cytopenia with unilineage dysplasia 45.15 11.46 25 267008 522 90360892
Loss of consciousness 45.08 11.46 236 266797 140002 90221412
Renal impairment 44.96 11.46 492 266541 104929 90256485
Candida sepsis 44.94 11.46 38 266995 1615 90359799
Enteritis 44.78 11.46 96 266937 10225 90351189
Sneezing 44.74 11.46 16 267017 29853 90331561
Lymphadenitis 44.67 11.46 58 266975 4079 90357335
Glioma 44.39 11.46 23 267010 418 90360996
Autoimmune haemolytic anaemia 44.39 11.46 68 266965 5577 90355837
Skin laceration 44.36 11.46 11 267022 26024 90335390
Accidental overdose 44.35 11.46 14 267019 28259 90333155
Madarosis 44.15 11.46 54 266979 3575 90357839
Intentional product use issue 44.13 11.46 417 266616 216475 90144939
Hydrothorax 43.99 11.46 31 267002 1002 90360412
Gas gangrene 43.91 11.46 17 267016 148 90361266
Gastroenteritis norovirus 43.88 11.46 44 266989 2332 90359082
Nightmare 43.81 11.46 6 267027 21719 90339695
Diastolic dysfunction 43.74 11.46 78 266955 7255 90354159
Limb injury 43.71 11.46 19 267014 31489 90329925
Fungal infection 43.57 11.46 244 266789 42417 90318997
Metastases to the mediastinum 43.47 11.46 26 267007 631 90360783
Triple negative breast cancer 43.36 11.46 22 267011 382 90361032
Influenza 43.30 11.46 237 266796 139027 90222387
Multiple sclerosis 43.29 11.46 14 267019 27826 90333588
Cystitis bacterial 43.26 11.46 21 267012 330 90361084
Cutaneous calcification 43.20 11.46 18 267015 193 90361221
Myelitis 43.09 11.46 41 266992 2037 90359377
Hemianopia 43.02 11.46 41 266992 2041 90359373
Paraparesis 42.88 11.46 48 266985 2890 90358524
Cervix disorder 42.61 11.46 26 267007 655 90360759
Shock 42.59 11.46 183 266850 28595 90332819
Nervous system disorder 42.29 11.46 150 266883 21443 90339971
Blast cells present 42.23 11.46 24 267009 528 90360886
Serotonin syndrome 42.23 11.46 30 267003 37857 90323557
Polyomavirus-associated nephropathy 42.16 11.46 44 266989 2446 90358968
Disseminated toxoplasmosis 41.85 11.46 17 267016 170 90361244
Engraft failure 41.84 11.46 21 267012 356 90361058
Intervertebral disc protrusion 41.72 11.46 14 267019 27182 90334232
Lumbosacral radiculoplexus neuropathy 41.45 11.46 11 267022 21 90361393
Metastases to peritoneum 41.39 11.46 56 266977 4099 90357315
Paraesthesia 41.38 11.46 505 266528 249821 90111593
Graft versus host disease in liver 41.25 11.46 29 267004 934 90360480
Adenoviral hepatitis 41.03 11.46 22 267011 430 90360984
Acute polyneuropathy 40.63 11.46 22 267011 439 90360975
Nail pigmentation 40.62 11.46 18 267015 227 90361187
Atypical haemolytic uraemic syndrome 40.50 11.46 29 267004 962 90360452
Vision blurred 40.47 11.46 177 266856 110116 90251298
Foetal growth restriction 40.41 11.46 87 266946 9293 90352121
Hypofibrinogenaemia 40.37 11.46 33 267000 1337 90360077
Injection site mass 40.32 11.46 8 267025 22082 90339332
Lymphoproliferative disorder 40.28 11.46 56 266977 4206 90357208
Hypoproteinaemia 40.26 11.46 48 266985 3094 90358320
Traumatic lung injury 40.25 11.46 37 266996 1759 90359655
Pustular psoriasis 40.22 11.46 4 267029 18552 90342862
Primary mediastinal large B-cell lymphoma recurrent 40.08 11.46 14 267019 88 90361326
Injection site warmth 40.08 11.46 3 267030 17512 90343902
Adenovirus reactivation 40.06 11.46 18 267015 235 90361179
Hepatic lesion 39.99 11.46 65 266968 5608 90355806
Respiratory distress 39.93 11.46 223 266810 38723 90322691
Surgery 39.85 11.46 44 266989 44843 90316571
Stenotrophomonas infection 39.82 11.46 43 266990 2486 90358928
Blood culture positive 39.75 11.46 61 266972 5011 90356403
Sweat gland tumour 39.74 11.46 16 267017 156 90361258
Klebsiella test positive 39.73 11.46 34 266999 1469 90359945
Graft versus host disease in lung 39.63 11.46 23 267010 527 90360887
Febrile infection 39.48 11.46 39 266994 2030 90359384
Herpes zoster meningoencephalitis 39.37 11.46 21 267012 406 90361008
Haemorrhage intracranial 39.37 11.46 116 266917 15046 90346368
Hormone receptor positive breast cancer 39.34 11.46 26 267007 755 90360659
Cytogenetic abnormality 39.33 11.46 23 267010 535 90360879
Meningitis 39.25 11.46 81 266952 8400 90353014
Pneumonia pneumococcal 39.19 11.46 44 266989 2658 90358756
Hypocalcaemia 39.15 11.46 236 266797 42132 90319282
Perineal necrosis 39.11 11.46 15 267018 127 90361287
Pyomyositis 39.10 11.46 21 267012 412 90361002
Haemolysis 39.06 11.46 81 266952 8429 90352985
Infusion site reaction 39.01 11.46 5 267028 19034 90342380
Immune-mediated hyperthyroidism 38.97 11.46 20 267013 356 90361058
Necrotising colitis 38.95 11.46 32 267001 1306 90360108
Blood pressure diastolic abnormal 38.91 11.46 6 267027 19875 90341539
Glomerulonephritis 38.90 11.46 42 266991 2428 90358986
Pseudocellulitis 38.81 11.46 15 267018 130 90361284
Lymphocytosis 38.75 11.46 46 266987 2951 90358463
Gastrointestinal fungal infection 38.69 11.46 21 267012 421 90360993
Optic atrophy 38.62 11.46 34 266999 1527 90359887
Skin haemorrhage 38.49 11.46 8 267025 21372 90340042
Systolic dysfunction 38.41 11.46 37 266996 1867 90359547
B-lymphocyte count decreased 38.36 11.46 33 267000 1436 90359978
Body mass index abnormal 38.20 11.46 25 267008 714 90360700
Cytomegalovirus urinary tract infection 38.15 11.46 13 267020 75 90361339
Acquired gene mutation 38.10 11.46 31 267002 1248 90360166
Paraesthesia oral 38.09 11.46 23 267010 31636 90329778
Metastatic lymphoma 38.04 11.46 17 267016 219 90361195
Scedosporium infection 38.02 11.46 26 267007 800 90360614
Perineal infection 37.80 11.46 16 267017 179 90361235
Haemodynamic instability 37.62 11.46 97 266936 11642 90349772
Marrow hyperplasia 37.59 11.46 25 267008 734 90360680
Human metapneumovirus test positive 37.59 11.46 13 267020 79 90361335
Dermatomyositis 37.57 11.46 48 266985 3322 90358092
Nodular regenerative hyperplasia 37.50 11.46 24 267009 659 90360755
Musculoskeletal disorder 37.47 11.46 9 267024 21760 90339654
Bronchiolitis obliterans syndrome 37.30 11.46 20 267013 391 90361023
Human herpesvirus 7 infection 37.28 11.46 15 267018 146 90361268
Focal nodular hyperplasia 37.20 11.46 25 267008 747 90360667
Mastectomy 37.18 11.46 38 266995 2061 90359353
Cystoid macular oedema 37.16 11.46 38 266995 2062 90359352
Foot fracture 36.97 11.46 16 267017 26590 90334824
Clostridium bacteraemia 36.84 11.46 17 267016 237 90361177
Haemolytic anaemia 36.82 11.46 96 266937 11601 90349813
Tissue infiltration 36.80 11.46 26 267007 844 90360570
Tuberculosis of central nervous system 36.69 11.46 19 267014 345 90361069
Laryngopharyngitis 36.64 11.46 12 267021 60 90361354
Growth retardation 36.63 11.46 35 266998 1748 90359666
Leukoerythroblastosis 36.57 11.46 18 267015 292 90361122
Tendonitis 36.47 11.46 9 267024 21363 90340051
Panic attack 36.41 11.46 16 267017 26349 90335065
Urinary tract infection bacterial 36.40 11.46 66 266967 6219 90355195
Minimal residual disease 36.28 11.46 20 267013 414 90361000
Delayed engraftment 36.25 11.46 14 267019 121 90361293
Hypouricaemia 36.21 11.46 17 267016 247 90361167
Oxygen saturation decreased 36.18 11.46 178 266855 107305 90254109
Ocular hyperaemia 36.07 11.46 28 267005 33770 90327644
Unintentional medical device removal 35.96 11.46 70 266963 6960 90354454
Trichosporon infection 35.87 11.46 19 267014 362 90361052
Femur fracture 35.84 11.46 50 266983 46032 90315382
Cachexia 35.81 11.46 69 266964 6809 90354605
Vaginal discharge 35.63 11.46 7 267026 19457 90341957
Withdrawal syndrome 35.60 11.46 11 267022 22513 90338901
Treatment noncompliance 35.57 11.46 61 266972 51666 90309748
Cerebral toxoplasmosis 35.56 11.46 31 267002 1374 90360040
IIIrd nerve paralysis 35.51 11.46 25 267008 807 90360607
Pulmonary oedema 35.44 11.46 308 266725 61772 90299642
Human herpesvirus 8 infection 35.41 11.46 19 267014 372 90361042
B-cell lymphoma refractory 35.25 11.46 12 267021 69 90361345
Serositis 35.24 11.46 30 267003 1287 90360127
Escherichia urinary tract infection 35.21 11.46 105 266928 13710 90347704
Steroid diabetes 35.02 11.46 40 266993 2462 90358952
Oligohydramnios 34.78 11.46 70 266963 7131 90354283
Procalcitonin increased 34.62 11.46 32 267001 1532 90359882
Paraneoplastic pemphigus 34.43 11.46 13 267020 105 90361309
Cryptococcosis 34.33 11.46 31 267002 1440 90359974
Citrobacter bacteraemia 34.32 11.46 9 267024 16 90361398
Cranial nerve disorder 34.32 11.46 23 267010 684 90360730
Product dose omission in error 34.28 11.46 9 267024 20494 90340920
Malignant pleural effusion 34.28 11.46 43 266990 2921 90358493
Brain oedema 34.24 11.46 121 266912 17264 90344150
Laryngitis fungal 34.22 11.46 15 267018 184 90361230
Eastern Cooperative Oncology Group performance status worsened 34.16 11.46 35 266998 1904 90359510
Blood fibrinogen decreased 34.10 11.46 28 267005 1142 90360272
Swelling face 34.00 11.46 124 266909 81228 90280186
Osteomyelitis bacterial 33.93 11.46 16 267017 235 90361179
Interleukin level increased 33.88 11.46 23 267010 699 90360715
Drug tolerance decreased 33.81 11.46 27 267006 32103 90329311
Norovirus infection 33.79 11.46 34 266999 1810 90359604
Tracheo-oesophageal fistula 33.77 11.46 23 267010 703 90360711
Poor venous access 33.76 11.46 8 267025 19519 90341895
Post transplant distal limb syndrome 33.70 11.46 18 267015 349 90361065
Myocardial infarction 33.68 11.46 179 266854 105793 90255621
Primary cardiac lymphoma 33.64 11.46 9 267024 18 90361396
Therapeutic product effect incomplete 33.63 11.46 387 266646 193509 90167905
Septic embolus 33.63 11.46 26 267007 971 90360443
Metastases to spine 33.63 11.46 48 266985 3695 90357719
Lymphadenopathy mediastinal 33.57 11.46 44 266989 3123 90358291
Superior vena cava syndrome 33.57 11.46 23 267010 710 90360704
Gamma-glutamyltransferase increased 33.55 11.46 209 266824 37743 90323671
PIK3CA-activated mutation 33.40 11.46 28 267005 1176 90360238
Pneumonia influenzal 33.38 11.46 37 266996 2203 90359211
Hip fracture 33.32 11.46 29 267004 33048 90328366
Campylobacter infection 33.23 11.46 28 267005 1184 90360230
Erythropoiesis abnormal 33.21 11.46 17 267016 301 90361113
Localised infection 33.11 11.46 30 267003 33532 90327882
B-cell lymphoma 33.11 11.46 47 266986 3599 90357815
Immune-mediated myocarditis 33.06 11.46 29 267004 1296 90360118
Therapy cessation 32.99 11.46 35 266998 36326 90325088
Blood pressure diastolic decreased 32.96 11.46 19 267014 26807 90334607
Influenza like illness 32.95 11.46 124 266909 80487 90280927
Stenotrophomonas bacteraemia 32.92 11.46 13 267020 120 90361294
Clonal evolution 32.90 11.46 12 267021 87 90361327
Hypertriglyceridaemia 32.65 11.46 72 266961 7817 90353597
Abortion spontaneous 32.57 11.46 69 266964 53987 90307427
Lactic acidosis 32.47 11.46 62 266971 50401 90311013
Sopor 32.42 11.46 16 267017 24628 90336786
Pseudomembranous colitis 32.42 11.46 48 266985 3820 90357594
Kidney infection 32.36 11.46 18 267015 25898 90335516
Central nervous system lupus 32.35 11.46 29 267004 1334 90360080
Arteritis 32.28 11.46 22 267011 673 90360741
Malnutrition 32.22 11.46 124 266909 18434 90342980
Ankle fracture 32.10 11.46 10 267023 20360 90341054
Hyperuricaemia 32.08 11.46 65 266968 6654 90354760
Coronary artery disease 32.06 11.46 31 267002 33592 90327822
Restless legs syndrome 32.05 11.46 13 267020 22457 90338957
Affect lability 32.03 11.46 7 267026 18056 90343358
Babesiosis 32.00 11.46 16 267017 269 90361145
Labelled drug-drug interaction medication error 31.98 11.46 3 267030 14579 90346835
Central nervous system infection 31.98 11.46 24 267009 857 90360557
Temperature regulation disorder 31.98 11.46 3 267030 14576 90346838
Epstein-Barr virus associated lymphoma 31.91 11.46 22 267011 686 90360728
Chronic graft versus host disease in liver 31.86 11.46 17 267016 329 90361085
T-cell lymphoma 31.80 11.46 23 267010 775 90360639
Product storage error 31.79 11.46 10 267023 20231 90341183
High-grade B-cell lymphoma 31.75 11.46 10 267023 43 90361371
Crying 31.75 11.46 18 267015 25627 90335787
Mood altered 31.74 11.46 6 267027 17138 90344276
Pneumonia klebsiella 31.51 11.46 42 266991 3030 90358384
Acute hepatic failure 31.51 11.46 141 266892 22420 90338994
Retinal haemorrhage 31.46 11.46 59 266974 5705 90355709
Rhinocerebral mucormycosis 31.45 11.46 23 267010 789 90360625
Tumour necrosis 31.38 11.46 25 267008 976 90360438
Precursor T-lymphoblastic lymphoma/leukaemia 31.38 11.46 11 267022 70 90361344
Incorrect product administration duration 31.33 11.46 9 267024 19313 90342101
Acute interstitial pneumonitis 31.27 11.46 23 267010 796 90360618
Neurological symptom 31.23 11.46 65 266968 6782 90354632
Fungal sepsis 31.19 11.46 30 267003 1511 90359903
Rash macular 31.17 11.46 26 267007 30254 90331160
Acute respiratory failure 31.12 11.46 225 266808 42693 90318721
Vena cava thrombosis 31.09 11.46 38 266995 2514 90358900
Vocal cord paralysis 30.93 11.46 37 266996 2393 90359021
Fungal endocarditis 30.92 11.46 17 267016 350 90361064
Combined immunodeficiency 30.91 11.46 13 267020 143 90361271
Pericardial effusion malignant 30.81 11.46 14 267019 188 90361226
Middle insomnia 30.72 11.46 6 267027 16745 90344669
Restlessness 30.64 11.46 36 266997 35684 90325730
Alternaria infection 30.53 11.46 17 267016 359 90361055
Spinal stenosis 30.40 11.46 7 267026 17417 90343997
Pulmonary mucormycosis 30.29 11.46 20 267013 580 90360834
Meningitis bacterial 30.26 11.46 31 267002 1686 90359728
Hepatosplenic T-cell lymphoma 30.23 11.46 21 267012 663 90360751
Hair colour changes 30.21 11.46 44 266989 3450 90357964
Immune-mediated enterocolitis 30.19 11.46 52 266981 4705 90356709
Respiratory tract infection fungal 30.17 11.46 19 267014 507 90360907
Bone marrow transplant rejection 30.12 11.46 11 267022 80 90361334
Alanine aminotransferase increased 30.04 11.46 503 266530 117835 90243579
Cerebral venous sinus thrombosis 29.95 11.46 36 266997 2340 90359074
Blood pressure systolic abnormal 29.92 11.46 10 267023 19468 90341946
Premature labour 29.78 11.46 97 266936 13279 90348135
Pulmonary fibrosis 29.68 11.46 190 266843 107313 90254101
Toxic skin eruption 29.55 11.46 108 266925 15666 90345748
Ligament sprain 29.52 11.46 4 267029 14595 90346819
Mucosal toxicity 29.47 11.46 17 267016 385 90361029
Leukaemic infiltration extramedullary 29.47 11.46 13 267020 162 90361252
Sleep apnoea syndrome 29.43 11.46 30 267003 31717 90329697
Monoparesis 29.38 11.46 33 267000 1994 90359420
Intentional dose omission 29.37 11.46 8 267025 17775 90343639
Product administration error 29.34 11.46 21 267012 26402 90335012
Dermatitis contact 29.29 11.46 3 267030 13592 90347822
Feeling jittery 29.28 11.46 5 267028 15366 90346048
Cholelithiasis 29.21 11.46 70 266963 52436 90308978
Coagulopathy 29.18 11.46 141 266892 23148 90338266
Vaccination failure 29.17 11.46 26 267007 1187 90360227
Clostridium colitis 29.14 11.46 33 267000 2012 90359402
Therapeutic response unexpected 29.09 11.46 14 267019 21866 90339548
Adenoviral haemorrhagic cystitis 29.05 11.46 13 267020 168 90361246
Product complaint 29.03 11.46 3 267030 13497 90347917
Agitation 28.88 11.46 101 266932 66997 90294417
Aspergilloma 28.88 11.46 15 267018 274 90361140
Enterobacter bacteraemia 28.87 11.46 22 267011 804 90360610
Hair follicle tumour benign 28.86 11.46 17 267016 401 90361013
Tremor 28.84 11.46 300 266733 152873 90208541
Transplant dysfunction 28.75 11.46 54 266979 5228 90356186
Reversible cerebral vasoconstriction syndrome 28.68 11.46 47 266986 4083 90357331
Pneumonia pseudomonal 28.66 11.46 41 266992 3162 90358252
Natural killer-cell leukaemia 28.59 11.46 11 267022 94 90361320
Parvovirus infection 28.56 11.46 18 267015 481 90360933
Seizure 28.53 11.46 619 266414 152010 90209404
Herpes zoster 28.49 11.46 414 266619 94230 90267184
Paraneoplastic syndrome 28.45 11.46 20 267013 644 90360770
Joint destruction 28.45 11.46 3 267030 13284 90348130
Morphoea 28.41 11.46 17 267016 413 90361001
Metastases to diaphragm 28.34 11.46 9 267024 40 90361374
Head injury 28.32 11.46 30 267003 31158 90330256
Miller Fisher syndrome 28.29 11.46 12 267021 135 90361279
Enterocolitis haemorrhagic 28.24 11.46 30 267003 1702 90359712
Necrotising gastritis 28.21 11.46 10 267023 66 90361348
Cyst 28.21 11.46 7 267026 16554 90344860
Radiation necrosis 28.21 11.46 20 267013 653 90360761
Immunosuppression 28.18 11.46 89 266944 11988 90349426
Soft tissue neoplasm 28.10 11.46 11 267022 99 90361315
Congenital cytomegalovirus infection 28.06 11.46 12 267021 138 90361276
Dyskinesia 28.06 11.46 40 266993 36494 90324920
Device breakage 28.04 11.46 4 267029 14040 90347374
Immune-mediated adverse reaction 28.02 11.46 22 267011 841 90360573
Large intestinal ulcer perforation 27.96 11.46 10 267023 68 90361346
Carpal tunnel syndrome 27.93 11.46 18 267015 23910 90337504
Meningoencephalitis viral 27.79 11.46 16 267017 361 90361053
Female genital tract fistula 27.75 11.46 9 267024 17859 90343555
Needle issue 27.74 11.46 4 267029 13930 90347484
Chylothorax 27.73 11.46 17 267016 432 90360982
Oral disorder 27.68 11.46 80 266953 10265 90351149
Scleroderma renal crisis 27.63 11.46 17 267016 435 90360979
Aspiration bone marrow 27.62 11.46 13 267020 190 90361224
Hyperviscosity syndrome 27.60 11.46 14 267019 243 90361171
Cardiac tamponade 27.50 11.46 55 266978 5577 90355837
Monocyte count decreased 27.47 11.46 36 266997 2555 90358859
Abdominal distension 27.46 11.46 249 266784 130352 90231062
General symptom 27.44 11.46 5 267028 14663 90346751
Enterocolitis infectious 27.43 11.46 32 267001 2015 90359399
Aspartate aminotransferase increased 27.41 11.46 441 266592 102496 90258918
Acute megakaryocytic leukaemia 27.32 11.46 9 267024 46 90361368
Laboratory test abnormal 27.30 11.46 51 266982 41803 90319611
Adult T-cell lymphoma/leukaemia 27.24 11.46 14 267019 250 90361164
Acute biphenotypic leukaemia 27.24 11.46 10 267023 74 90361340
Hypophosphataemia 27.23 11.46 101 266932 14753 90346661
Mycobacterial infection 27.07 11.46 33 267000 2177 90359237
Hyponatraemia 27.05 11.46 548 266485 132990 90228424
Acute lymphocytic leukaemia refractory 27.01 11.46 10 267023 76 90361338
Primary mediastinal large B-cell lymphoma 27 11.46 9 267024 48 90361366
Upper respiratory tract infection 26.82 11.46 245 266788 128073 90233341
Anisometropia 26.78 11.46 10 267023 78 90361336
Superinfection bacterial 26.77 11.46 23 267010 999 90360415
Deafness neurosensory 26.71 11.46 61 266972 6780 90354634
Listeria sepsis 26.60 11.46 20 267013 716 90360698
Leukaemic lymphoma 26.57 11.46 10 267023 80 90361334
Upper-airway cough syndrome 26.56 11.46 6 267027 15129 90346285
Subdural hygroma 26.56 11.46 14 267019 264 90361150
Secretion discharge 26.54 11.46 7 267026 15889 90345525
Rhinorrhoea 26.52 11.46 152 266881 88164 90273250
Muscle rigidity 26.50 11.46 5 267028 14304 90347110
Urinary tract infection 26.34 11.46 692 266341 304940 90056474
Cellulitis staphylococcal 26.30 11.46 22 267011 921 90360493
Infective aortitis 26.26 11.46 8 267025 30 90361384
Blood iron decreased 26.26 11.46 10 267023 17949 90343465
Chills 26.21 11.46 540 266493 131441 90229973
Arterial occlusive disease 26.16 11.46 3 267030 12443 90348971
Hepatitis B core antibody positive 26.15 11.46 15 267018 336 90361078
Postictal state 26.10 11.46 26 267007 1367 90360047
Pneumonia staphylococcal 26.05 11.46 42 266991 3599 90357815
Aeromonas infection 25.90 11.46 12 267021 169 90361245
Haematocolpos 25.84 11.46 9 267024 56 90361358
Mesenteric abscess 25.84 11.46 10 267023 87 90361327
Polyneuropathy in malignant disease 25.84 11.46 10 267023 87 90361327
Bone marrow necrosis 25.76 11.46 11 267022 126 90361288
Rhabdomyolysis 25.70 11.46 72 266961 51184 90310230
Rhabdomyosarcoma recurrent 25.67 11.46 8 267025 33 90361381
Epstein Barr virus positive mucocutaneous ulcer 25.65 11.46 18 267015 578 90360836
Parotitis 25.64 11.46 30 267003 1895 90359519
Gastroenteritis viral 25.60 11.46 31 267002 30324 90331090
Hepatic infarction 25.60 11.46 19 267014 667 90360747
General physical health deterioration 25.59 11.46 824 266209 354291 90007123
Cardiac cirrhosis 25.58 11.46 12 267021 174 90361240
Liver disorder 25.58 11.46 231 266802 121038 90240376
Irritability 25.50 11.46 41 266992 35621 90325793
Metaplasia 25.41 11.46 17 267016 504 90360910
Mucosal infection 25.40 11.46 12 267021 177 90361237
Nasal abscess 25.28 11.46 12 267021 179 90361235
Eye pain 25.28 11.46 58 266975 44110 90317304
Creatinine renal clearance decreased 25.27 11.46 12 267021 18887 90342527
Onycholysis 25.23 11.46 32 267001 2198 90359216
Tumour haemorrhage 25.22 11.46 31 267002 2063 90359351
Intracardiac thrombus 25.19 11.46 33 267000 2341 90359073
Device issue 25.08 11.46 30 267003 29507 90331907
Body temperature decreased 25.07 11.46 20 267013 23796 90337618
Lymphocytic leukaemia 25.04 11.46 12 267021 183 90361231
Prohormone brain natriuretic peptide increased 25.00 11.46 14 267019 299 90361115
Ovarian disorder 24.97 11.46 21 267012 886 90360528
Large intestine perforation 24.93 11.46 74 266959 9638 90351776
Symptom masked 24.78 11.46 22 267011 999 90360415
Mucoepidermoid carcinoma of salivary gland 24.76 11.46 8 267025 38 90361376
Pneumococcal sepsis 24.74 11.46 21 267012 897 90360517
Serum ferritin increased 24.70 11.46 62 266971 7319 90354095
Sarcoid-like reaction 24.64 11.46 12 267021 190 90361224
Actinomycotic sepsis 24.58 11.46 13 267020 247 90361167
HER2 positive breast cancer 24.54 11.46 16 267017 454 90360960
Aplasia pure red cell 24.50 11.46 50 266983 5144 90356270
Hypopituitarism 24.49 11.46 28 267005 1725 90359689
Peritonitis 24.47 11.46 119 266914 19586 90341828
Lung diffusion test decreased 24.45 11.46 20 267013 811 90360603
Pulmonary infarction 24.40 11.46 36 266997 2856 90358558
Hair texture abnormal 24.38 11.46 47 266986 4640 90356774
Metastases to breast 24.37 11.46 15 267018 384 90361030
Acute kidney injury 24.36 11.46 1166 265867 319221 90042193
Medulloblastoma recurrent 24.36 11.46 10 267023 103 90361311
Germ cell cancer 24.35 11.46 9 267024 68 90361346
Eye infection 24.33 11.46 6 267027 14248 90347166
Cholecystectomy 24.30 11.46 3 267030 11752 90349662
Pulmonary arterial hypertension 24.28 11.46 146 266887 26041 90335373
Systemic inflammatory response syndrome 24.23 11.46 57 266976 6459 90354955
Bone marrow infiltration 24.22 11.46 20 267013 822 90360592
Haemoglobin abnormal 24.14 11.46 60 266973 7040 90354374
Haematocrit decreased 24.11 11.46 208 266825 41624 90319790
Hypoperfusion 24.09 11.46 28 267005 1756 90359658
Opportunistic infection 24.07 11.46 31 267002 2162 90359252
Endocarditis 24.07 11.46 60 266973 7053 90354361
Small intestinal perforation 23.95 11.46 29 267004 1900 90359514
Cardiac failure chronic 23.90 11.46 52 266981 5594 90355820
Cholangiocarcinoma 23.83 11.46 24 267009 1279 90360135
Glaucoma 23.71 11.46 16 267017 20739 90340675
Adrenocorticotropic hormone deficiency 23.69 11.46 19 267014 749 90360665
Antithrombin III 23.67 11.46 11 267022 156 90361258
Impaired quality of life 23.67 11.46 20 267013 23124 90338290
Mucoepidermoid carcinoma 23.65 11.46 8 267025 45 90361369
Cytokine storm 23.63 11.46 17 267016 568 90360846
Dystonia 23.55 11.46 10 267023 16809 90344605
Ileus 23.55 11.46 104 266929 16442 90344972
Axillary lymphadenectomy 23.54 11.46 10 267023 113 90361301
Cutaneous mucormycosis 23.49 11.46 9 267024 76 90361338
Cryptosporidiosis infection 23.47 11.46 15 267018 411 90361003
Acquired macroglossia 23.47 11.46 12 267021 212 90361202
Endometrial adenocarcinoma 23.44 11.46 25 267008 1425 90359989
Atrial fibrillation 23.44 11.46 537 266496 133074 90228340
Microvascular coronary artery disease 23.41 11.46 13 267020 273 90361141
Immune-mediated thyroiditis 23.41 11.46 16 267017 492 90360922
Thrombotic thrombocytopenic purpura 23.39 11.46 43 266990 4095 90357319
Lymphangitis 23.39 11.46 21 267012 968 90360446
Obstructive airways disorder 23.36 11.46 25 267008 25844 90335570
Herpes simplex viraemia 23.34 11.46 15 267018 415 90360999
Dysphonia 23.28 11.46 101 266932 62983 90298431
Cell-mediated immune deficiency 23.28 11.46 9 267024 78 90361336
Deafness congenital 23.23 11.46 10 267023 117 90361297
Erythropenia 23.22 11.46 12 267021 217 90361197
Peripheral T-cell lymphoma unspecified 23.20 11.46 13 267020 278 90361136
Mediastinum neoplasm 23.18 11.46 9 267024 79 90361335
Pulmonary vasculitis 23.17 11.46 12 267021 218 90361196
Hilar lymphadenopathy 23.14 11.46 24 267009 1324 90360090
Fear 23.09 11.46 10 267023 16612 90344802
Primary immunodeficiency syndrome 23.08 11.46 8 267025 49 90361365
Pelvic fracture 23.06 11.46 8 267025 15211 90346203
Thyroid dermatopathy 23.03 11.46 7 267026 26 90361388
Left atrial enlargement 22.99 11.46 18 267015 685 90360729
Acidosis hyperchloraemic 22.95 11.46 20 267013 886 90360528
Neutrophil toxic granulation present 22.94 11.46 11 267022 168 90361246
Blood lactate dehydrogenase abnormal 22.84 11.46 15 267018 431 90360983
Gastritis fungal 22.83 11.46 11 267022 170 90361244
Cushingoid 22.80 11.46 75 266958 10320 90351094
Neuromuscular toxicity 22.79 11.46 13 267020 288 90361126
Nail disorder 22.77 11.46 93 266940 58974 90302440
Cytomegalovirus enteritis 22.76 11.46 14 267019 358 90361056
Sinus tachycardia 22.74 11.46 153 266880 28360 90333054
Growth hormone deficiency 22.71 11.46 11 267022 172 90361242
Depressed mood 22.71 11.46 74 266959 50148 90311266
Burkholderia pseudomallei infection 22.68 11.46 8 267025 52 90361362
Blindness 22.67 11.46 145 266888 26423 90334991
Bladder hypertrophy 22.66 11.46 16 267017 519 90360895
Drug dependence 22.63 11.46 32 267001 29295 90332119
Cardiac amyloidosis 22.55 11.46 21 267012 1015 90360399
Dysphagia 22.49 11.46 460 266573 111818 90249596
Hydronephrosis 22.46 11.46 84 266949 12318 90349096
Cardiac imaging procedure abnormal 22.42 11.46 6 267027 12 90361402
Gestational trophoblastic tumour 22.42 11.46 6 267027 12 90361402
Skin discolouration 22.40 11.46 62 266971 44253 90317161
Accidental exposure to product 22.38 11.46 58 266975 42308 90319106
Pneumonia adenoviral 22.36 11.46 12 267021 235 90361179
Arteritis infective 22.33 11.46 9 267024 88 90361326
Cerebellar haemangioma 22.33 11.46 9 267024 88 90361326
Intraductal proliferative breast lesion 22.25 11.46 38 266995 3415 90357999
Glomerulonephritis rapidly progressive 22.21 11.46 23 267010 1267 90360147
Device adhesion issue 22.18 11.46 56 266977 6635 90354779
Neutrophil percentage decreased 22.18 11.46 16 267017 537 90360877
Skin lesion 22.17 11.46 187 266846 37178 90324236
Anal infection 22.16 11.46 9 267024 90 90361324
Cytology abnormal 22.10 11.46 6 267027 13 90361401
Retinal toxicity 22.08 11.46 24 267009 1398 90360016
Cerebral infarction 21.99 11.46 144 266889 26452 90334962
Rhinitis allergic 21.92 11.46 11 267022 16774 90344640
Staphylococcus test positive 21.90 11.46 43 266990 4302 90357112
Diabetes mellitus inadequate control 21.89 11.46 14 267019 18670 90342744
Drug ineffective 21.88 11.46 4505 262528 1379793 88981621
Breast angiosarcoma 21.81 11.46 5 267028 3 90361411
Limb discomfort 21.76 11.46 50 266983 38010 90323404
Salivary gland cancer 21.73 11.46 11 267022 190 90361224
TP53 gene mutation 21.70 11.46 8 267025 60 90361354
Spinal cord compression 21.67 11.46 46 266987 4865 90356549
Gallbladder disorder 21.65 11.46 16 267017 19787 90341627
Microangiopathy 21.64 11.46 26 267007 1689 90359725
Cerebral aspergillosis 21.62 11.46 16 267017 559 90360855
Retinopathy 21.61 11.46 38 266995 3496 90357918
Pseudomonal bacteraemia 21.60 11.46 28 267005 1966 90359448
Wrong technique in product usage process 21.59 11.46 123 266910 71448 90289966
Cancer in remission 21.58 11.46 8 267025 61 90361353
Chronic lymphocytic leukaemia transformation 21.58 11.46 8 267025 61 90361353
Disseminated cryptococcosis 21.57 11.46 18 267015 751 90360663
Cytomegalovirus enterocolitis 21.55 11.46 19 267014 855 90360559
Chronic sinusitis 21.49 11.46 23 267010 23779 90337635
Chromosomal deletion 21.48 11.46 9 267024 98 90361316
Hepatic necrosis 21.46 11.46 54 266979 6384 90355030
Lymphomatoid papulosis 21.44 11.46 10 267023 143 90361271
Erysipelas 21.39 11.46 67 266966 8985 90352429
Mantle cell lymphoma 21.38 11.46 17 267016 662 90360752
Radiation myelopathy 21.37 11.46 7 267026 35 90361379
Device pacing issue 21.32 11.46 9 267024 100 90361314
Listeria encephalitis 21.32 11.46 12 267021 259 90361155
Blood calcium decreased 21.30 11.46 35 266998 30147 90331267
Granulicatella infection 21.26 11.46 10 267023 146 90361268
Device related bacteraemia 21.23 11.46 14 267019 405 90361009
Rash erythematous 21.23 11.46 109 266924 64995 90296419
Cytokine abnormal 21.22 11.46 5 267028 4 90361410
Lower respiratory tract infection fungal 21.20 11.46 12 267021 262 90361152
Pneumonitis chemical 21.15 11.46 13 267020 332 90361082
Breast cancer 21.15 11.46 247 266786 53514 90307900
Electrolyte imbalance 21.14 11.46 131 266902 23614 90337800
Acute generalised exanthematous pustulosis 21.11 11.46 7 267026 13696 90347718
Faeces discoloured 21.10 11.46 19 267014 21301 90340113
Cerebellar stroke 21.08 11.46 14 267019 410 90361004
Eye disorder 21.02 11.46 30 267003 27360 90334054
Pathogen resistance 20.99 11.46 62 266971 8053 90353361
Chemotherapeutic drug level increased 20.98 11.46 11 267022 205 90361209
Herpes simplex reactivation 20.93 11.46 20 267013 999 90360415
Haemolytic uraemic syndrome 20.90 11.46 33 267000 2778 90358636
Nasal septum disorder 20.89 11.46 11 267022 207 90361207
Gangrene 20.88 11.46 6 267027 12870 90348544
Metastases to thorax 20.87 11.46 12 267021 270 90361144
Central nervous system viral infection 20.84 11.46 10 267023 153 90361261
BK polyomavirus test positive 20.78 11.46 10 267023 154 90361260
Bradycardia 20.76 11.46 153 266880 83694 90277720
Tricuspid valve incompetence 20.75 11.46 101 266932 16630 90344784
Hypophysitis 20.73 11.46 31 267002 2489 90358925
Device electrical impedance issue 20.70 11.46 5 267028 5 90361409
Chronic graft versus host disease in intestine 20.67 11.46 10 267023 156 90361258
Morganella infection 20.64 11.46 18 267015 798 90360616
Impaired work ability 20.64 11.46 16 267017 19310 90342104
Stress cardiomyopathy 20.59 11.46 86 266947 13269 90348145
Pleural disorder 20.58 11.46 17 267016 699 90360715
Epistaxis 20.58 11.46 359 266674 84766 90276648
Cardiopulmonary failure 20.57 11.46 41 266992 4147 90357267
Hepatosplenomegaly 20.57 11.46 34 266999 2975 90358439
Immune-mediated dermatitis 20.52 11.46 19 267014 912 90360502
Fungal skin infection 20.40 11.46 47 266986 5254 90356160
Sputum discoloured 20.39 11.46 18 267015 20373 90341041
Myocardial fibrosis 20.38 11.46 19 267014 920 90360494
Hypogonadism 20.27 11.46 9 267024 114 90361300
Pharyngeal inflammation 20.26 11.46 20 267013 1040 90360374
Flushing 20.26 11.46 165 266868 88326 90273088
Colitis erosive 20.25 11.46 11 267022 221 90361193
Anaplastic large cell lymphoma T- and null-cell types recurrent 20.24 11.46 6 267027 20 90361394
Rib fracture 20.24 11.46 29 267004 26406 90335008
T-cell lymphoma recurrent 20.23 11.46 5 267028 6 90361408
Movement disorder 20.15 11.46 34 266999 28985 90332429
Disseminated cytomegaloviral infection 20.15 11.46 12 267021 289 90361125
Chronic myeloid leukaemia recurrent 20.11 11.46 12 267021 290 90361124
Breast neoplasm 20.02 11.46 24 267009 1556 90359858
Bronchiolitis 19.98 11.46 36 266997 3376 90358038
Anaesthesia 19.94 11.46 14 267019 450 90360964
Thinking abnormal 19.90 11.46 5 267028 11727 90349687
Lung disorder 19.88 11.46 316 266717 149567 90211847
Evans syndrome 19.87 11.46 13 267020 371 90361043
Urinary tract candidiasis 19.86 11.46 17 267016 735 90360679
Tinnitus 19.84 11.46 63 266970 43039 90318375
Poisoning 19.83 11.46 10 267023 15207 90346207
Heart rate abnormal 19.82 11.46 50 266983 5921 90355493
Histiocytic sarcoma 19.78 11.46 8 267025 79 90361335
Female sexual dysfunction 19.78 11.46 8 267025 79 90361335
Norovirus test positive 19.77 11.46 11 267022 232 90361182
Listeriosis 19.70 11.46 25 267008 1718 90359696
Retroperitoneal lymphadenopathy 19.70 11.46 17 267016 743 90360671
Herpes virus infection 19.69 11.46 52 266981 6332 90355082
Abdominal neoplasm 19.66 11.46 13 267020 378 90361036
Anal squamous cell carcinoma 19.64 11.46 16 267017 645 90360769
Clonal haematopoiesis 19.60 11.46 6 267027 23 90361391
Hypothyroidism 19.54 11.46 241 266792 52886 90308528
Hyperglycaemia 19.53 11.46 233 266800 50737 90310677
Dementia 19.46 11.46 25 267008 23836 90337578
Metastases to stomach 19.44 11.46 11 267022 240 90361174
Mucocutaneous ulceration 19.44 11.46 11 267022 240 90361174
Ovarian stromal hyperplasia 19.40 11.46 6 267027 24 90361390
Truncus arteriosus persistent 19.36 11.46 13 267020 388 90361026
Monoplegia 19.30 11.46 37 266996 3637 90357777
Hyperplasia 19.28 11.46 20 267013 1104 90360310
Chronic lymphocytic leukaemia 19.27 11.46 34 266999 3136 90358278
Hypersomnia 19.23 11.46 21 267012 21510 90339904
Amyloidosis 19.16 11.46 21 267012 1235 90360179
Glycosylated haemoglobin increased 19.15 11.46 11 267022 15551 90345863
Enterovirus test positive 19.05 11.46 10 267023 187 90361227
Liver carcinoma ruptured 19.04 11.46 7 267026 52 90361362
Non-Hodgkin's lymphoma recurrent 19.03 11.46 5 267028 9 90361405
Bone density decreased 18.98 11.46 14 267019 17331 90344083
Vertigo 18.95 11.46 124 266909 69687 90291727
Type 1 diabetes mellitus 18.89 11.46 43 266990 4769 90356645
Pseudomonas test positive 18.86 11.46 18 267015 898 90360516
Precursor B-lymphoblastic lymphoma 18.83 11.46 6 267027 27 90361387
Metastases to pancreas 18.83 11.46 12 267021 327 90361087
Pathological fracture 18.82 11.46 67 266966 9593 90351821
Epstein-Barr virus test positive 18.82 11.46 16 267017 685 90360729
Squamous cell carcinoma 18.79 11.46 69 266964 10032 90351382
Infusion site necrosis 18.78 11.46 8 267025 91 90361323
Hyponatraemic seizure 18.75 11.46 14 267019 496 90360918
Odynophagia 18.73 11.46 64 266969 8979 90352435
Sinus polyp 18.73 11.46 13 267020 410 90361004
Paraplegia 18.72 11.46 35 266998 3377 90358037
Mood swings 18.70 11.46 20 267013 20682 90340732
Hallucination, auditory 18.67 11.46 12 267021 15963 90345451
Paranasal sinus mucosal hypertrophy 18.66 11.46 6 267027 28 90361386
Spinal cord disorder 18.57 11.46 23 267010 1542 90359872
Immune reconstitution inflammatory syndrome 18.51 11.46 54 266979 6965 90354449
Forced vital capacity decreased 18.50 11.46 20 267013 1158 90360256
Skin mass 18.49 11.46 56 266977 7374 90354040
Central nervous system enteroviral infection 18.49 11.46 6 267027 29 90361385
Artificial menopause 18.49 11.46 6 267027 29 90361385
Akathisia 18.46 11.46 5 267028 11154 90350260
Glomerulonephritis membranoproliferative 18.45 11.46 12 267021 339 90361075
Gastric perforation 18.38 11.46 26 267007 1985 90359429
Hepatitis C RNA increased 18.34 11.46 9 267024 145 90361269
Asthenia 18.32 11.46 1818 265215 531933 89829481
Hepatic calcification 18.32 11.46 6 267027 30 90361384
Carotid intima-media thickness increased 18.26 11.46 8 267025 98 90361316
Mycobacterium abscessus infection 18.21 11.46 19 267014 1056 90360358
Diffuse large B-cell lymphoma stage IV 18.20 11.46 12 267021 347 90361067
Duodenal stenosis 18.20 11.46 15 267018 615 90360799
Mouth ulceration 18.17 11.46 189 266844 39785 90321629
Coronavirus infection 18.12 11.46 46 266987 5469 90355945
Metapneumovirus infection 18.11 11.46 21 267012 1314 90360100
Intra-abdominal haemorrhage 18.09 11.46 30 267003 2632 90358782
Plasma cells increased 18.04 11.46 8 267025 101 90361313
Refractory cancer 18.04 11.46 8 267025 101 90361313
Enterovirus infection 18.04 11.46 22 267011 1452 90359962
Infusion site swelling 18.03 11.46 6 267027 11714 90349700
Hyperproteinaemia 17.91 11.46 9 267024 153 90361261
Endocarditis bacterial 17.89 11.46 15 267018 630 90360784
Premature rupture of membranes 17.89 11.46 46 266987 5512 90355902
Low birth weight baby 17.89 11.46 65 266968 9402 90352012
Joint neoplasm 17.88 11.46 7 267026 63 90361351
Eosinophilic cystitis 17.88 11.46 7 267026 63 90361351
Herpes zoster infection neurological 17.88 11.46 14 267019 533 90360881
Immunoglobulins decreased 17.87 11.46 23 267010 1603 90359811
Adenocarcinoma 17.80 11.46 33 267000 3163 90358251
Burkitt's lymphoma 17.78 11.46 5 267028 13 90361401
Metastatic neoplasm 17.77 11.46 42 266991 4773 90356641
Diabetes insipidus 17.68 11.46 33 267000 3179 90358235
Primary adrenal insufficiency 17.65 11.46 11 267022 288 90361126
Tooth disorder 17.65 11.46 41 266992 31049 90330365
Blood glucose decreased 17.65 11.46 26 267007 23403 90338011
Meningitis staphylococcal 17.63 11.46 8 267025 107 90361307
Appendiceal abscess 17.62 11.46 11 267022 289 90361125
Eating disorder 17.62 11.46 35 266998 28038 90333376
Respiratory tract infection 17.61 11.46 258 266775 58820 90302594
Haemorrhage urinary tract 17.60 11.46 19 267014 1098 90360316
Thymus enlargement 17.60 11.46 9 267024 159 90361255
Hernia 17.60 11.46 10 267023 14221 90347193
Hypermetabolism 17.58 11.46 11 267022 290 90361124
Ocular vasculitis 17.57 11.46 8 267025 108 90361306
Syphilis 17.55 11.46 10 267023 221 90361193
Aortic wall hypertrophy 17.55 11.46 6 267027 35 90361379
Basal ganglion degeneration 17.53 11.46 12 267021 370 90361044
Skin cancer 17.45 11.46 9 267024 13510 90347904
C-reactive protein increased 17.44 11.46 404 266629 180985 90180429
Toxic erythema of chemotherapy 17.43 11.46 10 267023 224 90361190
Pleocytosis 17.40 11.46 18 267015 990 90360424
Cardiac ventricular thrombosis 17.37 11.46 19 267014 1115 90360299
Opsoclonus myoclonus 17.35 11.46 9 267024 164 90361250
Lymphocytic infiltration 17.34 11.46 19 267014 1117 90360297
Actinomycosis 17.34 11.46 19 267014 1117 90360297
Bone sarcoma 17.26 11.46 5 267028 15 90361399
Pleurodesis 17.26 11.46 5 267028 15 90361399
CD4/CD8 ratio decreased 17.26 11.46 5 267028 15 90361399
Retinal vasculitis 17.26 11.46 22 267011 1519 90359895
Gastric stenosis 17.23 11.46 7 267026 70 90361344
Parkinsonism 17.23 11.46 10 267023 14055 90347359
Exposure during pregnancy 17.21 11.46 553 266480 237857 90123557
Fungal oesophagitis 17.19 11.46 16 267017 773 90360641
Pharyngitis streptococcal 17.18 11.46 8 267025 12734 90348680
Cataract 17.16 11.46 133 266900 71959 90289455
Cholestasis 17.16 11.46 173 266860 36126 90325288
Anti-glomerular basement membrane disease 17.14 11.46 7 267026 71 90361343
Transfusion reaction 17.11 11.46 20 267013 1262 90360152
Rash vesicular 17.09 11.46 17 267016 18180 90343234
Paroxysmal atrioventricular block 17.09 11.46 4 267029 3 90361411
Cardiac murmur 17.09 11.46 17 267016 18177 90343237
Meningitis pneumococcal 17.09 11.46 13 267020 474 90360940
Chronic hepatitis B 17.08 11.46 12 267021 386 90361028
Anaphylactic reaction 17.06 11.46 170 266863 87354 90274060
Human herpes virus 8 test positive 17.02 11.46 5 267028 16 90361398
Infusion site streaking 17.01 11.46 14 267019 573 90360841
Corynebacterium sepsis 17.01 11.46 6 267027 39 90361375
Pain in jaw 17 11.46 78 266955 47907 90313507
Foot operation 16.98 11.46 3 267030 8998 90352416
Disseminated aspergillosis 16.92 11.46 13 267020 481 90360933
Body height decreased 16.90 11.46 7 267026 11942 90349472
Deafness 16.88 11.46 119 266914 22395 90339019
Neurological decompensation 16.87 11.46 34 266999 3467 90357947
Tooth fracture 16.85 11.46 8 267025 12592 90348822
Adrenal insufficiency 16.84 11.46 148 266885 29773 90331641
Congenital cardiovascular anomaly 16.83 11.46 13 267020 485 90360929
Citrobacter infection 16.83 11.46 15 267018 685 90360729
Tachypnoea 16.79 11.46 114 266919 21195 90340219
American trypanosomiasis 16.78 11.46 10 267023 241 90361173
Central nervous system leukaemia 16.78 11.46 10 267023 241 90361173
Transient hypogammaglobulinaemia of infancy 16.75 11.46 6 267027 41 90361373
Muscle strain 16.68 11.46 4 267029 9683 90351731
Facial paralysis 16.63 11.46 90 266943 15444 90345970
Hepatosplenic candidiasis 16.60 11.46 11 267022 321 90361093
Myasthenia gravis crisis 16.60 11.46 18 267015 1046 90360368
VIth nerve paresis 16.56 11.46 7 267026 78 90361336
Retinal fovea disorder 16.56 11.46 4 267029 4 90361410
Emotional disorder 16.55 11.46 12 267021 14985 90346429
Breast cancer stage I 16.52 11.46 4 267029 9620 90351794
Full blood count abnormal 16.49 11.46 54 266979 36543 90324871
Anger 16.46 11.46 10 267023 13710 90347704
Hiatus hernia 16.45 11.46 31 267002 25330 90336084
Acute cutaneous lupus erythematosus 16.45 11.46 11 267022 326 90361088
Central nervous system lesion 16.42 11.46 73 266960 11573 90349841
Extravasation blood 16.41 11.46 8 267025 127 90361287
Glomerulonephritis membranous 16.41 11.46 15 267018 708 90360706
Median nerve injury 16.36 11.46 5 267028 19 90361395
Lymph node fibrosis 16.36 11.46 5 267028 19 90361395
Ataxia 16.35 11.46 100 266933 17942 90343472
Acute hepatitis C 16.33 11.46 7 267026 81 90361333
Epilepsy 16.30 11.46 159 266874 82047 90279367
Haematopoietic stem cell mobilisation 16.27 11.46 6 267027 45 90361369
Pulse waveform abnormal 16.25 11.46 7 267026 82 90361332
Urinary tract infection viral 16.25 11.46 7 267026 82 90361332
Cytomegalovirus gastritis 16.24 11.46 11 267022 333 90361081
Diffuse alopecia 16.23 11.46 19 267014 1201 90360213
Pleural neoplasm 16.22 11.46 12 267021 419 90360995
Atrial thrombosis 16.20 11.46 26 267007 2219 90359195
Skin irritation 16.20 11.46 10 267023 13593 90347821
Ankle brachial index decreased 16.18 11.46 7 267026 83 90361331
Infusion site eschar 16.16 11.46 5 267028 20 90361394
Fusobacterium infection 16.16 11.46 6 267027 46 90361368
Lipidosis 16.16 11.46 6 267027 46 90361368
Immune-mediated hepatic disorder 16.13 11.46 23 267010 1769 90359645
Blood pressure decreased 16.08 11.46 142 266891 74753 90286661
Drug reaction with eosinophilia and systemic symptoms 16.06 11.46 68 266965 42690 90318724
Gastritis haemorrhagic 16.05 11.46 23 267010 1777 90359637
Orthostatic hypotension 16.03 11.46 66 266967 41761 90319653
Transient ischaemic attack 16.01 11.46 69 266964 43107 90318307
Congenital syphilitic osteochondritis 15.97 11.46 5 267028 21 90361393
Pericardial calcification 15.97 11.46 5 267028 21 90361393
Renal hydrocele 15.97 11.46 5 267028 21 90361393
Peritonitis viral 15.94 11.46 6 267027 48 90361366
Lymphatic duct injury 15.94 11.46 6 267027 48 90361366
Fasciitis 15.93 11.46 14 267019 627 90360787
Maternal exposure timing unspecified 15.93 11.46 26 267007 22457 90338957
Chronic cutaneous lupus erythematosus 15.93 11.46 16 267017 850 90360564
Cytotoxic oedema 15.92 11.46 9 267024 196 90361218
Blood bilirubin increased 15.91 11.46 197 266836 43273 90318141
Mediastinitis 15.87 11.46 11 267022 346 90361068
Fluid replacement 15.86 11.46 14 267019 631 90360783
Splenic infarction 15.86 11.46 25 267008 2102 90359312
Psychomotor hyperactivity 15.85 11.46 9 267024 12804 90348610
Jaw operation 15.85 11.46 16 267017 855 90360559
Dermatofibrosarcoma protuberans 15.83 11.46 6 267027 49 90361365
Chromosome analysis abnormal 15.81 11.46 8 267025 138 90361276
Cerebral fungal infection 15.81 11.46 10 267023 269 90361145
Overlap syndrome 15.80 11.46 3 267030 8545 90352869
Toxic neuropathy 15.73 11.46 13 267020 535 90360879
Menopause 15.70 11.46 32 267001 3289 90358125
Retching 15.70 11.46 20 267013 19139 90342275
Rotavirus infection 15.69 11.46 12 267021 441 90360973
Cerebral artery thrombosis 15.67 11.46 12 267021 442 90360972
Head discomfort 15.64 11.46 15 267018 16318 90345096
Tumour marker increased 15.63 11.46 45 266988 5762 90355652
Metastases to heart 15.60 11.46 9 267024 204 90361210
Thirst 15.56 11.46 15 267018 16280 90345134
Acinetobacter infection 15.53 11.46 24 267009 1984 90359430
Conjunctival scar 15.52 11.46 6 267027 52 90361362
Respiratory moniliasis 15.52 11.46 9 267024 206 90361208
Nausea 15.50 11.46 3593 263440 1106723 89254691
Radiation pneumonitis 15.49 11.46 23 267010 1835 90359579
Periorbital cellulitis 15.49 11.46 15 267018 762 90360652
Portal vein embolism 15.47 11.46 7 267026 93 90361321
Ultrasound foetal abnormal 15.46 11.46 8 267025 145 90361269
Hypophagia 15.44 11.46 168 266865 35769 90325645
Herpes oesophagitis 15.44 11.46 9 267024 208 90361206
Mycoplasma infection 15.44 11.46 16 267017 882 90360532
Creatinine renal clearance 15.43 11.46 5 267028 24 90361390
Red blood cell schistocytes present 15.38 11.46 11 267022 364 90361050
Overgrowth fungal 15.36 11.46 8 267025 147 90361267
Cardiac septal defect 15.36 11.46 15 267018 770 90360644
Infection in an immunocompromised host 15.32 11.46 16 267017 890 90360524
Reproductive toxicity 15.30 11.46 4 267029 7 90361407
Renal tubular disorder 15.28 11.46 31 267002 3176 90358238
Aggression 15.28 11.46 35 266998 26633 90334781
Scleromalacia 15.27 11.46 5 267028 25 90361389
Galectin-3 increased 15.27 11.46 5 267028 25 90361389
Chimerism 15.27 11.46 5 267028 25 90361389
Granulocytosis 15.27 11.46 8 267025 149 90361265
Immune-mediated nephritis 15.25 11.46 12 267021 460 90360954
Oesophagitis 15.25 11.46 95 266938 17154 90344260
Upper limb fracture 15.25 11.46 25 267008 21553 90339861
Epidermal necrosis 15.24 11.46 26 267007 2335 90359079
Anti-platelet antibody positive 15.23 11.46 6 267027 55 90361359
Rhabdoid tumour 15.23 11.46 6 267027 55 90361359
Increased tendency to bruise 15.22 11.46 8 267025 11882 90349532
Herpes zoster cutaneous disseminated 15.18 11.46 9 267024 215 90361199
Xerophthalmia 15.15 11.46 14 267019 670 90360744
Lung abscess 15.12 11.46 25 267008 2188 90359226
Rosai-Dorfman syndrome 15.10 11.46 5 267028 26 90361388
Dysstasia 15.07 11.46 32 267001 25020 90336394
Respiratory tract infection bacterial 15.01 11.46 12 267021 471 90360943
Osmotic demyelination syndrome 15.01 11.46 17 267016 1037 90360377
Axillary vein thrombosis 15.00 11.46 11 267022 379 90361035
Hepatic cytolysis 14.93 11.46 148 266885 30768 90330646
Microscopic polyangiitis 14.92 11.46 9 267024 222 90361192
Synovial cyst 14.91 11.46 8 267025 11744 90349670
Status epilepticus 14.89 11.46 101 266932 18773 90342641
Cryptococcal fungaemia 14.83 11.46 7 267026 103 90361311
Anal ulcer 14.82 11.46 15 267018 804 90360610
Venous haemorrhage 14.82 11.46 10 267023 301 90361113
Rotator cuff syndrome 14.81 11.46 15 267018 15904 90345510
Cold type haemolytic anaemia 14.79 11.46 10 267023 302 90361112
BRCA1 gene mutation 14.77 11.46 6 267027 60 90361354
Disseminated strongyloidiasis 14.77 11.46 6 267027 60 90361354
Areflexia 14.74 11.46 33 267000 3620 90357794
Adjustment disorder 14.72 11.46 5 267028 9637 90351777
Mucocutaneous leishmaniasis 14.72 11.46 11 267022 390 90361024
Scoliosis 14.72 11.46 4 267029 8903 90352511
Chronic graft versus host disease oral 14.71 11.46 9 267024 228 90361186
Bartholinitis 14.68 11.46 6 267027 61 90361353
Pneumonia respiratory syncytial viral 14.68 11.46 19 267014 1332 90360082
Disseminated tuberculosis 14.67 11.46 31 267002 3268 90358146
Metastases to spleen 14.67 11.46 9 267024 229 90361185
Campylobacter gastroenteritis 14.67 11.46 15 267018 814 90360600
Renal cell carcinoma 14.66 11.46 34 266999 3817 90357597
Skin hyperpigmentation 14.64 11.46 49 266984 6802 90354612
Hypotelorism of orbit 14.63 11.46 4 267029 9 90361405
Proctitis 14.63 11.46 14 267019 15245 90346169
Blood pressure abnormal 14.60 11.46 22 267011 19623 90341791
Atrial rupture 14.60 11.46 6 267027 62 90361352
Neurologic neglect syndrome 14.57 11.46 4 267029 8843 90352571
Bacillus infection 14.57 11.46 16 267017 943 90360471
Enteral nutrition 14.57 11.46 9 267024 232 90361182
Clostridial infection 14.54 11.46 38 266995 4598 90356816
Pulmonary tuberculosis 14.53 11.46 39 266994 4795 90356619
Rubulavirus test positive 14.49 11.46 3 267030 0 90361414
Peripheral nerve infection 14.49 11.46 3 267030 0 90361414
Precursor B-lymphoblastic lymphoma recurrent 14.49 11.46 3 267030 0 90361414
Lymphoid tissue hypoplasia 14.49 11.46 3 267030 0 90361414
Ovarian Sertoli-Leydig cell tumour 14.49 11.46 3 267030 0 90361414
Oral fungal infection 14.46 11.46 31 267002 3301 90358113
Product administered to patient of inappropriate age 14.45 11.46 38 266995 4615 90356799
Angioimmunoblastic T-cell lymphoma 14.43 11.46 9 267024 236 90361178
Respiratory arrest 14.43 11.46 50 266983 33261 90328153
Iron deficiency anaemia 14.42 11.46 30 267003 23632 90337782
Myofascitis 14.37 11.46 5 267028 31 90361383
Puncture site haematoma 14.35 11.46 6 267027 65 90361349
Hypotension 14.34 11.46 1129 265904 324268 90037146
Increased liver stiffness 14.34 11.46 4 267029 10 90361404
Li-Fraumeni syndrome 14.34 11.46 4 267029 10 90361404
Mantle cell lymphoma refractory 14.34 11.46 4 267029 10 90361404
Papule 14.33 11.46 54 266979 7948 90353466
Hypoglossal nerve paresis 14.31 11.46 7 267026 112 90361302
Pancreatic atrophy 14.31 11.46 10 267023 319 90361095
Secondary adrenocortical insufficiency 14.27 11.46 25 267008 2293 90359121
Metastases to uterus 14.25 11.46 7 267026 113 90361301
Merycism 14.25 11.46 10 267023 321 90361093
Subacute sclerosing panencephalitis 14.24 11.46 5 267028 32 90361382
Cardio-respiratory distress 14.20 11.46 8 267025 173 90361241
Culture stool positive 14.17 11.46 10 267023 324 90361090
Bladder disorder 14.16 11.46 7 267026 10765 90350649
Metastases to retroperitoneum 14.16 11.46 8 267025 174 90361240
Restrictive cardiomyopathy 14.14 11.46 10 267023 325 90361089
Renal artery arteriosclerosis 14.11 11.46 5 267028 33 90361381
Jejunal stenosis 14.11 11.46 6 267027 68 90361346
Human T-cell lymphotropic virus type I infection 14.11 11.46 6 267027 68 90361346
Platelet count abnormal 14.08 11.46 36 266997 4299 90357115
Eosinophil count decreased 14.08 11.46 30 267003 3182 90358232
Endocardial fibrosis 14.07 11.46 4 267029 11 90361403
Neonatal lupus erythematosus 14.07 11.46 4 267029 11 90361403
Blast cell count increased 14.05 11.46 12 267021 517 90360897
Neuroblastoma recurrent 14.04 11.46 8 267025 177 90361237
Light chain analysis increased 13.99 11.46 20 267013 1542 90359872
Low cardiac output syndrome 13.97 11.46 11 267022 422 90360992
Splenic vein thrombosis 13.97 11.46 11 267022 422 90360992
Diffuse large B-cell lymphoma stage II 13.95 11.46 6 267027 70 90361344
Squamous cell carcinoma of skin 13.95 11.46 51 266982 7398 90354016
Hodgkin's disease 13.95 11.46 14 267019 743 90360671
Chloroma 13.94 11.46 9 267024 251 90361163
Acute coronary syndrome 13.93 11.46 66 266967 10747 90350667
Intracranial pressure increased 13.93 11.46 48 266985 6763 90354651
Immune-mediated lung disease 13.88 11.46 22 267011 1858 90359556
Injection site phlebitis 13.88 11.46 7 267026 120 90361294
Jejunal ulcer perforation 13.86 11.46 5 267028 35 90361379
Microsporidia infection 13.85 11.46 10 267023 336 90361078
Coronary artery occlusion 13.84 11.46 4 267029 8550 90352864
Tumour pain 13.82 11.46 22 267011 1865 90359549
Cerebral cavernous malformation 13.81 11.46 4 267029 12 90361402
Pulmonary imaging procedure abnormal 13.81 11.46 4 267029 12 90361402
Mastoid disorder 13.80 11.46 6 267027 72 90361342
Hypophosphatasia 13.80 11.46 6 267027 72 90361342
Bronchostenosis 13.78 11.46 12 267021 531 90360883
Device related sepsis 13.74 11.46 38 266995 4755 90356659
Gait apraxia 13.74 11.46 5 267028 36 90361378
Superior mesenteric artery syndrome 13.72 11.46 7 267026 123 90361291
Neutrophil count increased 13.68 11.46 101 266932 19289 90342125
Hepatitis B surface antigen positive 13.66 11.46 6 267027 74 90361340
Autoimmune neutropenia 13.63 11.46 9 267024 261 90361153
Myocardial oedema 13.58 11.46 11 267022 440 90360974
T-lymphocyte count decreased 13.57 11.46 10 267023 347 90361067
Acral peeling skin syndrome 13.57 11.46 4 267029 13 90361401
Measles post vaccine 13.57 11.46 4 267029 13 90361401
Generalised tonic-clonic seizure 13.57 11.46 160 266873 34743 90326671
Cortisol decreased 13.57 11.46 21 267012 1738 90359676
Blood phosphorus decreased 13.54 11.46 39 266994 4995 90356419
Meningoencephalitis herpetic 13.54 11.46 19 267014 1440 90359974
Abnormal behaviour 13.53 11.46 29 267004 22599 90338815
Increased appetite 13.53 11.46 9 267024 11756 90349658
Left ventricular enlargement 13.52 11.46 6 267027 76 90361338
Leukaemic infiltration 13.50 11.46 5 267028 38 90361376
Immune-mediated hepatitis 13.49 11.46 28 267005 2916 90358498
Extrapyramidal disorder 13.38 11.46 17 267016 16286 90345128
Lymph node pain 13.37 11.46 21 267012 1760 90359654
Coma 13.36 11.46 143 266890 72489 90288925
Spinal disorder 13.34 11.46 9 267024 11670 90349744
Pulmonary nocardiosis 13.33 11.46 14 267019 784 90360630
Febrile convulsion 13.31 11.46 12 267021 556 90360858
Product dispensing error 13.31 11.46 10 267023 12263 90349151
Necrotising herpetic retinopathy 13.28 11.46 7 267026 132 90361282
Ovarian cyst 13.26 11.46 19 267014 17299 90344115
Blood cholinesterase decreased 13.17 11.46 8 267025 200 90361214
Acute lung injury 13.15 11.46 19 267014 1479 90359935
Lymphadenectomy 13.14 11.46 17 267016 1191 90360223
Pericarditis constrictive 13.13 11.46 12 267021 566 90360848
Tension headache 13.13 11.46 3 267030 7506 90353908
Vascular compression 13.13 11.46 9 267024 278 90361136
Ventricular arrhythmia 13.13 11.46 35 266998 4286 90357128
Metabolic acidosis 13.12 11.46 103 266930 55573 90305841
Deformity 13.09 11.46 10 267023 12160 90349254
Coordination abnormal 13.08 11.46 27 267006 21329 90340085
Choroidal detachment 13.07 11.46 9 267024 280 90361134
Radiation mucositis 13.07 11.46 5 267028 42 90361372
Pulmonary vascular disorder 13.06 11.46 10 267023 368 90361046
Hepatitis fulminant 13.06 11.46 33 267000 3912 90357502
Blood stem cell harvest failure 12.98 11.46 6 267027 84 90361330
Lung adenocarcinoma 12.97 11.46 41 266992 5524 90355890
Ovarian necrosis 12.97 11.46 5 267028 43 90361371
Facial paresis 12.96 11.46 33 267000 3930 90357484
Mycobacterium haemophilum infection 12.96 11.46 8 267025 206 90361208
Myelitis transverse 12.94 11.46 19 267014 1501 90359913
Trichodysplasia spinulosa 12.93 11.46 13 267020 691 90360723
Beta 2 microglobulin decreased 12.93 11.46 4 267029 16 90361398
Renal pseudoaneurysm 12.93 11.46 4 267029 16 90361398
Delusion 12.92 11.46 13 267020 13827 90347587
Micrococcus infection 12.92 11.46 6 267027 85 90361329
Water intoxication 12.90 11.46 12 267021 579 90360835
Stenotrophomonas sepsis 12.87 11.46 5 267028 44 90361370
Skin maceration 12.82 11.46 8 267025 210 90361204
Mucosal erosion 12.82 11.46 21 267012 1824 90359590
Vulvovaginal inflammation 12.81 11.46 16 267017 1082 90360332
Hepatitis G 12.79 11.46 6 267027 87 90361327
Tuberous sclerosis complex 12.79 11.46 6 267027 87 90361327
Oedema due to cardiac disease 12.77 11.46 5 267028 45 90361369
Corynebacterium infection 12.75 11.46 15 267018 953 90360461
Brain herniation 12.74 11.46 34 266999 4166 90357248
Proteus test positive 12.72 11.46 10 267023 383 90361031
Miosis 12.71 11.46 6 267027 9478 90351936
Malignant ascites 12.70 11.46 15 267018 957 90360457
Skin burning sensation 12.70 11.46 24 267009 19587 90341827
Renal amyloidosis 12.69 11.46 9 267024 294 90361120
Lymphatic disorder 12.68 11.46 11 267022 484 90360930
Chronic lymphocytic leukaemia refractory 12.67 11.46 5 267028 46 90361368
Lineage switch leukaemia 12.67 11.46 5 267028 46 90361368
Vascular injury 12.67 11.46 16 267017 1094 90360320
Subcutaneous emphysema 12.65 11.46 16 267017 1096 90360318
Genitourinary symptom 12.65 11.46 7 267026 146 90361268
Carotidynia 12.65 11.46 7 267026 146 90361268
Fracture 12.62 11.46 29 267004 22047 90339367
Obstruction gastric 12.62 11.46 17 267016 1239 90360175
Gallbladder enlargement 12.57 11.46 15 267018 968 90360446
T-cell prolymphocytic leukaemia 12.55 11.46 4 267029 18 90361396
Chronic graft versus host disease in eye 12.55 11.46 8 267025 218 90361196
Pulmonary vein stenosis 12.55 11.46 6 267027 91 90361323
Scintillating scotoma 12.52 11.46 7 267026 149 90361265
Liver scan abnormal 12.49 11.46 5 267028 48 90361366
Splenic necrosis 12.49 11.46 5 267028 48 90361366
Retinitis pigmentosa 12.44 11.46 7 267026 151 90361263
Myocardial stunning 12.43 11.46 9 267024 304 90361110
Arachnoid cyst 12.43 11.46 9 267024 304 90361110
Viral hepatitis carrier 12.42 11.46 3 267030 3 90361411
Blood beta-D-glucan abnormal 12.42 11.46 3 267030 3 90361411
Follicle centre lymphoma, follicular grade I, II, III stage IV 12.42 11.46 3 267030 3 90361411
Allogenic bone marrow transplantation therapy 12.42 11.46 3 267030 3 90361411
Breast prosthesis removal 12.42 11.46 3 267030 3 90361411
Gastrointestinal mucormycosis 12.40 11.46 9 267024 305 90361109
Bone neoplasm 12.38 11.46 14 267019 852 90360562
Mitral valve disease 12.35 11.46 25 267008 2557 90358857
Granulomatosis with polyangiitis 12.33 11.46 25 267008 2560 90358854
Viral sepsis 12.31 11.46 5 267028 50 90361364
Parenteral nutrition 12.30 11.46 8 267025 226 90361188
Poikiloderma 12.30 11.46 9 267024 309 90361105
Chronic hepatitis 12.28 11.46 16 267017 1129 90360285
Diarrhoea haemorrhagic 12.25 11.46 63 266970 10600 90350814
Kaposi's sarcoma 12.24 11.46 7 267026 156 90361258
Frustration tolerance decreased 12.22 11.46 4 267029 7892 90353522
Fat necrosis 12.22 11.46 13 267020 739 90360675
Cytomegalovirus oesophagitis 12.22 11.46 10 267023 406 90361008
Pneumonia viral 12.21 11.46 55 266978 8768 90352646
KMT2A gene mutation 12.21 11.46 4 267029 20 90361394
Malignant neoplasm of orbit 12.21 11.46 4 267029 20 90361394
Extranodal marginal zone B-cell lymphoma (MALT type) recurrent 12.21 11.46 4 267029 20 90361394
Lymphatic obstruction 12.21 11.46 4 267029 20 90361394
Marginal zone lymphoma 12.21 11.46 6 267027 97 90361317
White blood cell disorder 12.21 11.46 27 267006 2937 90358477
Mucosal ulceration 12.19 11.46 16 267017 1137 90360277
Hypertensive encephalopathy 12.18 11.46 13 267020 742 90360672
Paratracheal lymphadenopathy 12.14 11.46 5 267028 52 90361362
Serum sickness 12.11 11.46 30 267003 3512 90357902
Postoperative wound infection 12.09 11.46 13 267020 13413 90348001
Subacute combined cord degeneration 12.09 11.46 8 267025 233 90361181
Papillary thyroid cancer 12.05 11.46 25 267008 2602 90358812
Marginal zone lymphoma recurrent 12.05 11.46 4 267029 21 90361393
Splenic marginal zone lymphoma 12.05 11.46 5 267028 53 90361361
Feeling cold 12.05 11.46 41 266992 27424 90333990
Injection site induration 12.05 11.46 8 267025 10460 90350954
West Nile viral infection 12.02 11.46 11 267022 520 90360894
Hypersensitivity pneumonitis 12.02 11.46 32 267001 3916 90357498
Respiratory depression 12.01 11.46 17 267016 15558 90345856
Heliotrope rash 11.97 11.46 8 267025 237 90361177
Tooth infection 11.94 11.46 26 267007 20144 90341270
Abdominal abscess 11.93 11.46 39 266994 5348 90356066
Acute erythroid leukaemia 11.92 11.46 7 267026 164 90361250
Immune-mediated encephalitis 11.91 11.46 11 267022 526 90360888
Candida test positive 11.90 11.46 15 267018 1024 90360390
Streptococcal sepsis 11.88 11.46 30 267003 3554 90357860
Haptoglobin decreased 11.85 11.46 15 267018 1028 90360386
Breast conserving surgery 11.85 11.46 16 267017 1169 90360245
Vaginal infection 11.85 11.46 5 267028 8435 90352979
Mycobacterium chelonae infection 11.83 11.46 12 267021 645 90360769
Blood corticotrophin decreased 11.83 11.46 11 267022 531 90360883
Cerebral ventricle dilatation 11.82 11.46 15 267018 1031 90360383
Bulbar palsy 11.81 11.46 5 267028 56 90361358
Respiratory disorder 11.77 11.46 128 266905 64688 90296726
Alopecia totalis 11.77 11.46 10 267023 428 90360986
Immunodeficiency common variable 11.77 11.46 10 267023 428 90360986
Lacrimal haemorrhage 11.75 11.46 4 267029 23 90361391
Diverticulum 11.75 11.46 11 267022 12102 90349312
Lethargy 11.74 11.46 124 266909 63015 90298399
Single functional kidney 11.74 11.46 9 267024 332 90361082
Encopresis 11.73 11.46 6 267027 106 90361308
Pituitary enlargement 11.73 11.46 5 267028 57 90361357
SARS-CoV-2 test negative 11.72 11.46 11 267022 537 90360877
Soft tissue sarcoma 11.70 11.46 7 267026 170 90361244
Flagellate dermatitis 11.70 11.46 7 267026 170 90361244
Natural killer cell count decreased 11.68 11.46 6 267027 107 90361307
Hereditary motor and sensory neuropathy 11.68 11.46 6 267027 107 90361307
Pelvic fluid collection 11.67 11.46 15 267018 1044 90360370
Gastric neoplasm 11.67 11.46 9 267024 335 90361079
Thrombophlebitis 11.65 11.46 36 266997 4792 90356622
Blood creatine phosphokinase increased 11.64 11.46 56 266977 33967 90327447
Dandy-Walker syndrome 11.63 11.46 6 267027 108 90361306
Bladder perforation 11.63 11.46 7 267026 172 90361242
Paraproteinaemia 11.62 11.46 8 267025 249 90361165
Dysaesthesia 11.60 11.46 38 266995 5217 90356197
Product preparation error 11.60 11.46 8 267025 10253 90351161
Urethritis 11.59 11.46 8 267025 250 90361164
Sinusitis aspergillus 11.58 11.46 6 267027 109 90361305
Relapsing-remitting multiple sclerosis 11.57 11.46 13 267020 786 90360628
Autonomic nervous system imbalance 11.57 11.46 29 267004 3421 90357993
Pulmonary necrosis 11.52 11.46 7 267026 175 90361239
Pancreatitis acute 11.52 11.46 145 266888 31970 90329444
Positron emission tomogram abnormal 11.51 11.46 9 267024 342 90361072
Hand fracture 11.50 11.46 3 267030 6862 90354552
Lichenoid keratosis 11.49 11.46 24 267009 2510 90358904
Roseolovirus test positive 11.49 11.46 6 267027 111 90361303
Out of specification test results 11.49 11.46 6 267027 111 90361303
CSF volume increased 11.47 11.46 4 267029 25 90361389
Urinary bladder sarcoma 11.47 11.46 4 267029 25 90361389
Hepatic candidiasis 11.47 11.46 4 267029 25 90361389
Lymphocyte adoptive therapy 11.47 11.46 4 267029 25 90361389
Invasive breast carcinoma 11.47 11.46 14 267019 925 90360489

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 5563.33 12.37 5756 214706 179947 42220926
Cytokine release syndrome 2525.67 12.37 1984 218478 42543 42358330
Disease progression 2465.60 12.37 3358 217104 140298 42260575
Myelosuppression 2033.38 12.37 1680 218782 38781 42362092
Neutropenia 1833.73 12.37 3510 216952 195921 42204952
Off label use 1274.13 12.37 6566 213896 631769 41769104
Mucosal inflammation 1047.38 12.37 1284 219178 48090 42352783
Myelodysplastic syndrome 1027.90 12.37 889 219573 21856 42379017
Hypogammaglobulinaemia 1016.38 12.37 680 219782 11211 42389662
Diffuse large B-cell lymphoma recurrent 1000.33 12.37 494 219968 4392 42396481
Product use in unapproved indication 999.28 12.37 2632 217830 181824 42219049
Cystitis haemorrhagic 978.38 12.37 557 219905 6772 42394101
Cytomegalovirus infection reactivation 921.32 12.37 625 219837 10553 42390320
Acute graft versus host disease 896.28 12.37 548 219914 7667 42393206
Bone marrow failure 873.05 12.37 963 219499 32130 42368743
Pancytopenia 840.46 12.37 1870 218592 115873 42285000
Cytomegalovirus infection 840.00 12.37 933 219529 31373 42369500
Progressive multifocal leukoencephalopathy 819.87 12.37 589 219873 10947 42389926
Haematotoxicity 769.55 12.37 556 219906 10429 42390444
Acute myeloid leukaemia 749.18 12.37 738 219724 21518 42379355
Hepatitis B 717.62 12.37 442 220020 6269 42394604
Immune effector cell-associated neurotoxicity syndrome 690.58 12.37 491 219971 8970 42391903
Chronic graft versus host disease 675.43 12.37 409 220053 5616 42395257
Thrombocytopenia 662.80 12.37 2326 218136 187953 42212920
Venoocclusive liver disease 650.88 12.37 490 219972 9812 42391061
Acute graft versus host disease in skin 649.92 12.37 431 220031 6993 42393880
Therapy partial responder 637.16 12.37 644 219818 19377 42381496
Graft versus host disease 636.70 12.37 531 219931 12394 42388479
Cytopenia 635.50 12.37 605 219857 16892 42383981
Second primary malignancy 608.43 12.37 457 220005 9118 42391755
BK virus infection 593.46 12.37 435 220027 8349 42392524
Product dose omission issue 576.70 12.37 63 220399 154302 42246571
Fall 556.23 12.37 259 220203 234261 42166612
Tumour lysis syndrome 550.34 12.37 626 219836 21605 42379268
Pyrexia 550.11 12.37 3699 216763 390343 42010530
Hepatitis B reactivation 547.51 12.37 324 220138 4254 42396619
Neutrophil count decreased 517.28 12.37 1064 219398 62351 42338522
Drug abuse 514.16 12.37 5 220457 104766 42296107
Arthralgia 476.83 12.37 233 220229 205005 42195868
Septic shock 473.73 12.37 1287 219175 90385 42310488
Venoocclusive disease 465.37 12.37 276 220186 3639 42397234
Completed suicide 462.66 12.37 7 220455 96458 42304415
Pneumocystis jirovecii pneumonia 457.98 12.37 607 219855 24574 42376299
Sepsis 453.59 12.37 2136 218326 197198 42203675
Dizziness 453.10 12.37 375 220087 248879 42151994
Drug interaction 451.40 12.37 430 220032 266569 42134304
Fatigue 448.65 12.37 995 219467 434646 41966227
Neurotoxicity 434.57 12.37 573 219889 23078 42377795
Disease recurrence 416.38 12.37 632 219830 29046 42371827
Neoplasm progression 414.59 12.37 623 219839 28377 42372496
Diffuse large B-cell lymphoma 407.79 12.37 360 220102 9094 42391779
Posterior reversible encephalopathy syndrome 403.48 12.37 410 220052 12411 42388462
Graft versus host disease in skin 397.76 12.37 278 220184 4934 42395939
Haemophagocytic lymphohistiocytosis 395.93 12.37 480 219982 17742 42383131
Dyspnoea 379.80 12.37 1109 219353 441512 41959361
Febrile bone marrow aplasia 377.20 12.37 356 220106 9825 42391048
Adenovirus infection 371.61 12.37 297 220165 6512 42394361
Pruritus 355.36 12.37 274 220188 188497 42212376
Neutropenic sepsis 351.26 12.37 423 220039 15523 42385350
Epstein-Barr virus infection 347.08 12.37 333 220129 9385 42391488
Inappropriate schedule of product administration 345.93 12.37 44 220418 95858 42305015
Leukopenia 345.43 12.37 1008 219454 73738 42327135
Anxiety 343.58 12.37 94 220368 118466 42282407
Pain 339.06 12.37 463 219999 244385 42156488
Rash 338.96 12.37 570 219892 276384 42124489
Graft versus host disease in gastrointestinal tract 334.59 12.37 249 220213 4894 42395979
Lymphopenia 333.84 12.37 481 219981 21082 42379791
White blood cell count decreased 331.86 12.37 1288 219174 109108 42291765
Overdose 325.31 12.37 73 220389 105191 42295682
Aspergillus infection 321.22 12.37 403 220059 15434 42385439
Somnolence 304.23 12.37 176 220286 140929 42259944
Lymphadenopathy 303.32 12.37 586 219876 32779 42368094
Cardiotoxicity 300.32 12.37 273 220189 7172 42393701
Myocardial infarction 298.20 12.37 134 220328 123875 42276998
Diffuse large B-cell lymphoma refractory 280.61 12.37 157 220305 1840 42399033
Post transplant lymphoproliferative disorder 273.12 12.37 284 220178 8836 42392037
Malaise 272.17 12.37 423 220039 211733 42189140
Blood lactate dehydrogenase increased 269.50 12.37 484 219978 25597 42375276
Thrombotic microangiopathy 265.15 12.37 354 220108 14428 42386445
Infection 260.28 12.37 1209 219253 110859 42290014
Insomnia 259.89 12.37 144 220318 118109 42282764
Pain in extremity 258.28 12.37 239 220223 150365 42250508
Rhabdomyolysis 257.95 12.37 46 220416 77973 42322900
Blood pressure increased 254.82 12.37 104 220358 101824 42299049
Bronchopulmonary aspergillosis 254.62 12.37 401 220061 19028 42381845
Depression 250.00 12.37 132 220330 111231 42289642
Intentional overdose 249.86 12.37 3 220459 51453 42349420
Cytomegalovirus chorioretinitis 249.22 12.37 200 220262 4411 42396462
Acute lymphocytic leukaemia recurrent 243.02 12.37 180 220282 3511 42397362
Drug ineffective 241.54 12.37 4581 215881 625616 41775257
Platelet count decreased 236.50 12.37 1372 219090 137209 42263664
Malignant neoplasm progression 233.25 12.37 1144 219318 107256 42293617
Injection site pain 227.78 12.37 19 220443 57779 42343094
Drug ineffective for unapproved indication 226.20 12.37 636 219826 45527 42355346
Feeling abnormal 224.60 12.37 44 220418 69742 42331131
Muscle spasms 221.30 12.37 84 220378 85960 42314913
Hospitalisation 217.02 12.37 58 220404 74272 42326601
Multiple organ dysfunction syndrome 216.61 12.37 1035 219427 96000 42304873
Joint swelling 216.59 12.37 44 220418 67978 42332895
Cytomegalovirus viraemia 215.12 12.37 267 220195 10110 42390763
Acute graft versus host disease in intestine 212.75 12.37 171 220291 3780 42397093
Suicidal ideation 210.36 12.37 9 220453 48152 42352721
Peripheral swelling 210.07 12.37 102 220360 90168 42310705
Respiratory failure 207.92 12.37 1252 219210 126880 42273993
Suicide attempt 206.88 12.37 7 220455 46093 42354780
Intentional product misuse 205.69 12.37 36 220426 61864 42339009
Musculoskeletal stiffness 204.67 12.37 28 220434 57737 42343136
Candida infection 201.85 12.37 384 220078 21226 42379647
Therapy non-responder 201.45 12.37 671 219791 52688 42348185
Viral haemorrhagic cystitis 197.90 12.37 122 220340 1732 42399141
Neuropathy peripheral 197.46 12.37 1044 219418 100809 42300064
Stress 193.98 12.37 8 220454 44204 42356669
Chest pain 193.71 12.37 263 220199 139267 42261606
Fungal infection 193.61 12.37 358 220104 19364 42381509
Psoriasis 191.46 12.37 16 220446 48588 42352285
B-cell lymphoma recurrent 190.95 12.37 92 220370 770 42400103
Encephalitis cytomegalovirus 189.47 12.37 103 220359 1136 42399737
Cystitis viral 189.23 12.37 103 220359 1139 42399734
Klebsiella infection 189.01 12.37 262 220200 11070 42389803
Death 188.41 12.37 1548 218914 469637 41931236
Epstein-Barr viraemia 186.20 12.37 127 220335 2162 42398711
Drug hypersensitivity 185.88 12.37 145 220317 99244 42301629
Headache 181.98 12.37 632 219830 238737 42162136
Loss of personal independence in daily activities 179.23 12.37 23 220439 49793 42351080
Hyperhidrosis 177.06 12.37 126 220336 90386 42310487
Lymphoma 175.89 12.37 287 220175 14034 42386839
Gait disturbance 175.77 12.37 149 220313 97851 42303022
Incorrect dose administered 175.59 12.37 31 220431 52943 42347930
Aggression 175.45 12.37 14 220448 44149 42356724
Toxicity to various agents 174.15 12.37 605 219857 228531 42172342
Plasma cell myeloma recurrent 173.68 12.37 180 220282 5577 42395296
Nasopharyngitis 172.24 12.37 111 220351 83885 42316988
Coronary artery disease 170.49 12.37 35 220427 53685 42347188
Mantle cell lymphoma recurrent 170.34 12.37 90 220372 933 42399940
Dry skin 169.90 12.37 24 220438 48314 42352559
Chronic graft versus host disease in skin 169.70 12.37 105 220357 1501 42399372
Acquired gene mutation 168.73 12.37 104 220358 1476 42399397
Weight increased 168.34 12.37 186 220276 107797 42293076
Weight decreased 166.25 12.37 537 219925 207411 42193462
Engraftment syndrome 165.21 12.37 98 220364 1292 42399581
Polyneuropathy 164.99 12.37 324 220138 18337 42382536
Abdominal discomfort 164.76 12.37 92 220370 75163 42325710
Asthenia 163.98 12.37 821 219641 279972 42120901
Nausea 161.00 12.37 1298 219164 395501 42005372
Sleep disorder 159.72 12.37 28 220434 48067 42352806
Neoplasm recurrence 157.62 12.37 123 220339 2601 42398272
Herpes simplex 157.52 12.37 189 220273 6906 42393967
JC virus infection 157.48 12.37 128 220334 2876 42397997
Loss of consciousness 156.53 12.37 148 220314 92206 42308667
Chronic obstructive pulmonary disease 155.10 12.37 66 220396 63048 42337825
Urticaria 152.94 12.37 97 220365 73939 42326934
Epstein-Barr virus infection reactivation 152.83 12.37 119 220343 2508 42398365
Lymphocyte count decreased 149.01 12.37 396 220066 27413 42373460
Blood glucose increased 148.92 12.37 99 220363 73600 42327273
Pseudomonas infection 146.30 12.37 281 220181 15642 42385231
Agranulocytosis 145.29 12.37 417 220045 30195 42370678
Hypoglycaemia 144.85 12.37 64 220398 59790 42341083
Systemic mycosis 138.59 12.37 108 220354 2279 42398594
Diarrhoea 137.82 12.37 1624 218838 459225 41941648
Bacteraemia 137.66 12.37 360 220102 24680 42376193
Nephropathy toxic 135.33 12.37 281 220181 16557 42384316
Clostridium difficile colitis 135.17 12.37 323 220139 20929 42379944
Aplasia 134.68 12.37 145 220317 4698 42396175
Epstein-Barr virus associated lymphoproliferative disorder 132.10 12.37 106 220356 2337 42398536
Cerebrovascular accident 131.91 12.37 186 220276 96974 42303899
Myalgia 131.38 12.37 183 220279 95897 42304976
Wrong technique in product usage process 130.77 12.37 30 220432 42605 42358268
Escherichia sepsis 130.73 12.37 155 220307 5592 42395281
Hallucination 130.71 12.37 67 220395 57440 42343433
Bacterial sepsis 129.91 12.37 164 220298 6318 42394555
Rheumatoid arthritis 129.90 12.37 30 220432 42410 42358463
Asthma 128.21 12.37 82 220380 62232 42338641
Enterococcal infection 127.65 12.37 226 220236 11813 42389060
Confusional state 127.58 12.37 442 220020 167155 42233718
Human polyomavirus infection 127.15 12.37 81 220381 1222 42399651
Staphylococcal bacteraemia 126.04 12.37 215 220247 10906 42389967
Heart rate decreased 124.11 12.37 20 220442 36512 42364361
Hyperkalaemia 123.82 12.37 140 220322 80318 42320555
Pneumonia cytomegaloviral 122.66 12.37 128 220334 3998 42396875
Staphylococcal sepsis 120.68 12.37 214 220248 11200 42389673
Bradycardia 119.71 12.37 160 220302 85324 42315549
Escherichia infection 119.63 12.37 213 220249 11183 42389690
Wheezing 118.41 12.37 68 220394 54713 42346160
Erythema 117.60 12.37 241 220221 108552 42292321
Sedation 117.40 12.37 11 220451 30464 42370409
Human herpesvirus 6 infection 116.63 12.37 100 220362 2425 42398448
Central nervous system lymphoma 115.41 12.37 78 220384 1307 42399566
Leukoencephalopathy 114.98 12.37 135 220327 4819 42396054
Sweat gland tumour 113.55 12.37 52 220410 383 42400490
Accidental overdose 112.47 12.37 9 220453 28321 42372552
Pneumonia fungal 111.91 12.37 183 220279 8963 42391910
Blood creatine phosphokinase increased 111.83 12.37 55 220407 48283 42352590
Contusion 111.28 12.37 39 220423 41946 42358927
Constipation 111.11 12.37 447 220015 161844 42239029
B-cell type acute leukaemia 109.40 12.37 62 220400 746 42400127
Pneumonia 109.05 12.37 2905 217557 419244 41981629
Nightmare 108.15 12.37 5 220457 25007 42375866
Tremor 107.95 12.37 211 220251 96718 42304155
Transplant failure 107.09 12.37 118 220344 3926 42396947
International normalised ratio increased 106.69 12.37 58 220404 48110 42352763
Anaemia 105.95 12.37 2036 218426 278242 42122631
Drug resistance 104.69 12.37 402 220060 33846 42367027
Product prescribing error 104.49 12.37 8 220454 26104 42374769
Lymphoproliferative disorder 104.47 12.37 106 220356 3201 42397672
Acute graft versus host disease in liver 101.73 12.37 83 220379 1875 42398998
Cytokine increased 101.37 12.37 34 220428 91 42400782
Hepatic failure 100.35 12.37 427 220035 37673 42363200
Angioedema 100.30 12.37 47 220415 42430 42358443
Gastrointestinal toxicity 100.04 12.37 113 220349 3866 42397007
Drug dependence 98.67 12.37 16 220446 29078 42371795
Back pain 98.61 12.37 388 220074 141388 42259485
Stem cell transplant 98.13 12.37 93 220369 2579 42398294
Plasma cell myeloma refractory 97.88 12.37 71 220391 1339 42399534
Swelling 97.69 12.37 84 220378 54801 42346072
Hepatotoxicity 97.18 12.37 319 220143 24848 42376025
Graft versus host disease in liver 96.99 12.37 75 220387 1564 42399309
Heart rate increased 96.64 12.37 80 220382 53175 42347698
Psoriatic arthropathy 96.20 12.37 9 220453 24958 42375915
Toxoplasmosis 96.11 12.37 74 220388 1533 42399340
Mucormycosis 95.75 12.37 149 220313 6994 42393879
Eczema 95.02 12.37 29 220433 34057 42366816
Abdominal pain upper 94.45 12.37 177 220285 82432 42318441
Acute myeloid leukaemia recurrent 93.91 12.37 103 220359 3409 42397464
Chest discomfort 93.26 12.37 115 220347 63501 42337372
Plasmacytoma 93.21 12.37 114 220348 4250 42396623
Post transplant distal limb syndrome 92.91 12.37 46 220416 411 42400462
Cytomegalovirus test positive 92.53 12.37 113 220349 4206 42396667
Arthropathy 92.43 12.37 20 220442 29577 42371296
Klebsiella sepsis 91.64 12.37 90 220372 2611 42398262
Agitation 91.44 12.37 119 220343 64195 42336678
Cerebral toxoplasmosis 90.68 12.37 80 220382 2018 42398855
Acute lymphocytic leukaemia 90.66 12.37 100 220362 3331 42397542
Stomatitis 89.42 12.37 504 219958 49825 42351048
COVID-19 88.84 12.37 954 219508 114994 42285879
Colitis ulcerative 87.42 12.37 15 220447 26160 42374713
Nephrolithiasis 86.58 12.37 41 220421 36789 42364084
Neutropenic colitis 86.27 12.37 111 220351 4359 42396514
Arthritis 85.64 12.37 56 220406 42009 42358864
Osteonecrosis 85.06 12.37 226 220236 15639 42385234
Decreased appetite 85.02 12.37 617 219845 192520 42208353
Lactic acidosis 84.61 12.37 66 220396 45195 42355678
Aplastic anaemia 83.96 12.37 193 220269 12191 42388682
Human herpesvirus 6 encephalitis 83.76 12.37 47 220415 554 42400319
Peripheral T-cell lymphoma unspecified 83.40 12.37 47 220415 559 42400314
Vertigo 82.66 12.37 37 220425 34310 42366563
Medication error 82.52 12.37 34 220428 33120 42367753
Gastrooesophageal reflux disease 82.48 12.37 67 220395 44956 42355917
Mobility decreased 81.93 12.37 40 220422 35266 42365607
Frequent bowel movements 81.73 12.37 8 220454 21399 42379474
Syncope 81.21 12.37 254 220208 99152 42301721
Swollen tongue 80.89 12.37 8 220454 21223 42379650
Haematochezia 80.15 12.37 111 220351 58325 42342548
Skin toxicity 80.08 12.37 131 220331 6418 42394455
Device related infection 80.05 12.37 259 220203 20020 42380853
Dehydration 80.02 12.37 419 220043 141348 42259525
Dry mouth 79.96 12.37 54 220408 39825 42361048
Electrocardiogram QT prolonged 79.84 12.37 78 220384 47867 42353006
Psychotic disorder 79.36 12.37 26 220436 29182 42371691
Cardiac failure congestive 79.28 12.37 206 220256 85396 42315477
Chronic lymphocytic leukaemia recurrent 79.14 12.37 47 220415 621 42400252
Hot flush 78.76 12.37 11 220451 22340 42378533
Palpitations 78.56 12.37 88 220374 50709 42350164
Enterococcal bacteraemia 77.96 12.37 82 220380 2585 42398288
Flushing 77.15 12.37 48 220414 36980 42363893
Autoimmune haemolytic anaemia 77.00 12.37 119 220343 5552 42395321
Abdominal distension 76.57 12.37 160 220302 71575 42329298
Injection site erythema 75.93 12.37 8 220454 20187 42380686
Balance disorder 75.38 12.37 81 220381 47564 42353309
Minimal residual disease 74.38 12.37 44 220418 577 42400296
Granulocyte count decreased 74.20 12.37 63 220399 1507 42399366
Strongyloidiasis 73.88 12.37 90 220372 3341 42397532
Sleep disorder due to a general medical condition 73.83 12.37 4 220458 17449 42383424
Oedema peripheral 73.03 12.37 409 220053 135667 42265206
Transient ischaemic attack 72.73 12.37 42 220420 33697 42367176
B-lymphocyte count decreased 72.55 12.37 49 220413 820 42400053
Infection reactivation 72.38 12.37 72 220390 2122 42398751
Leukaemia recurrent 72.17 12.37 67 220395 1809 42399064
Human herpesvirus 6 infection reactivation 71.90 12.37 39 220423 428 42400445
Injection site swelling 71.46 12.37 4 220458 16969 42383904
Lymphoma transformation 69.82 12.37 40 220422 492 42400381
Lymphoid tissue hypoplasia 69.73 12.37 48 220414 830 42400043
Restlessness 69.61 12.37 32 220430 29217 42371656
Graft versus host disease in lung 69.29 12.37 45 220417 703 42400170
Engraft failure 69.02 12.37 41 220421 542 42400331
Thrombosis 68.84 12.37 158 220304 68353 42332520
Treatment failure 68.43 12.37 556 219906 62068 42338805
Adverse drug reaction 68.20 12.37 56 220406 37378 42363495
Thymus hypoplasia 68.16 12.37 47 220415 815 42400058
Chronic graft versus host disease in liver 67.82 12.37 43 220419 643 42400230
Myelopathy 67.46 12.37 79 220383 2812 42398061
Product quality issue 67.44 12.37 7 220455 17875 42382998
Hepatitis E 67.15 12.37 82 220380 3052 42397821
Therapy interrupted 65.60 12.37 17 220445 22233 42378640
Polyomavirus viraemia 65.45 12.37 67 220395 2045 42398828
Depressed mood 64.99 12.37 20 220442 23364 42377509
Staphylococcal infection 64.91 12.37 374 220088 37269 42363604
Treatment noncompliance 64.23 12.37 60 220402 37612 42363261
Vision blurred 64.10 12.37 112 220350 53587 42347286
Head injury 64.08 12.37 14 220448 20568 42380305
Varicella zoster virus infection 63.92 12.37 73 220389 2528 42398345
Surgery 63.67 12.37 8 220454 17608 42383265
Adenovirus reactivation 63.65 12.37 34 220428 361 42400512
Dyskinesia 63.25 12.37 26 220436 25364 42375509
Blood stem cell transplant failure 63.25 12.37 36 220426 437 42400436
Accidental exposure to product 63.23 12.37 14 220448 20379 42380494
Skin exfoliation 63.15 12.37 73 220389 41480 42359393
Blood fibrinogen decreased 63.12 12.37 58 220404 1545 42399328
Drug reaction with eosinophilia and systemic symptoms 62.78 12.37 75 220387 42000 42358873
Fusarium infection 62.72 12.37 58 220404 1558 42399315
Bacterial infection 62.56 12.37 298 220164 27581 42373292
Nocardiosis 62.36 12.37 103 220359 5087 42395786
Candida sepsis 62.25 12.37 55 220407 1390 42399483
Irritability 62.09 12.37 34 220428 28094 42372779
Clostridium difficile infection 62.03 12.37 257 220205 22402 42378471
Labelled drug-drug interaction medication error 61.71 12.37 5 220457 15577 42385296
Chloroma 61.66 12.37 38 220424 539 42400334
Synovitis 61.64 12.37 5 220457 15562 42385311
Acute myelomonocytic leukaemia 61.47 12.37 27 220435 178 42400695
Heart rate irregular 61.27 12.37 6 220456 16044 42384829
Disseminated aspergillosis 61.23 12.37 59 220403 1671 42399202
Hypersensitivity 60.45 12.37 183 220279 72187 42328686
Extrapyramidal disorder 60.44 12.37 7 220455 16405 42384468
Dyspepsia 60.34 12.37 75 220387 41277 42359596
Bone marrow necrosis 60.31 12.37 30 220432 271 42400602
Pseudomonal bacteraemia 60.16 12.37 68 220394 2328 42398545
Cardiomyopathy 59.94 12.37 227 220235 18983 42381890
Cardio-respiratory arrest 59.90 12.37 134 220328 58502 42342371
Anaplastic lymphoma kinase gene mutation 59.62 12.37 23 220439 103 42400770
Therapeutic product effect decreased 59.26 12.37 69 220393 39081 42361792
Pneumonia klebsiella 59.19 12.37 90 220372 4139 42396734
Osteoarthritis 59.18 12.37 26 220436 24379 42376494
Unevaluable event 59.18 12.37 54 220408 34234 42366639
Amnesia 59.06 12.37 37 220425 28400 42372473
Oxygen saturation decreased 58.87 12.37 157 220305 64530 42336343
Memory impairment 58.81 12.37 106 220356 50116 42350757
Incorrect route of product administration 58.77 12.37 26 220436 24279 42376594
Rectal haemorrhage 58.72 12.37 104 220358 49502 42351371
Blood pressure fluctuation 58.71 12.37 33 220429 26875 42373998
Injury 58.66 12.37 21 220441 22295 42378578
Blood pressure systolic increased 58.62 12.37 36 220426 27932 42372941
Herpes zoster 58.60 12.37 373 220089 38504 42362369
Neck pain 58.37 12.37 42 220420 29972 42370901
Lung infiltration 58.26 12.37 182 220280 13807 42387066
Multiple sclerosis relapse 58.13 12.37 4 220458 14260 42386613
Microsporidia infection 58.11 12.37 48 220414 1104 42399769
Herpes virus infection 58.06 12.37 83 220379 3609 42397264
Dysgeusia 57.64 12.37 55 220407 34134 42366739
Nervousness 57.56 12.37 3 220459 13529 42387344
Pseudomonal sepsis 57.46 12.37 89 220373 4160 42396713
Bone marrow transplant rejection 57.39 12.37 27 220435 213 42400660
Refractory cytopenia with multilineage dysplasia 57.27 12.37 23 220439 117 42400756
Hyperlipidaemia 56.98 12.37 20 220442 21496 42379377
Abnormal behaviour 56.91 12.37 33 220429 26418 42374455
Nervous system disorder 56.83 12.37 207 220255 16988 42383885
Scedosporium infection 56.78 12.37 54 220408 1504 42399369
Illness 56.70 12.37 29 220433 24901 42375972
Bone marrow infiltration 56.65 12.37 27 220435 220 42400653
Blood cholesterol increased 56.64 12.37 34 220428 26707 42374166
Alpha haemolytic streptococcal infection 56.53 12.37 59 220403 1843 42399030
Flatulence 56.11 12.37 30 220432 25122 42375751
Cytogenetic abnormality 55.96 12.37 43 220419 888 42399985
Encephalitis 55.88 12.37 137 220325 9021 42391852
Osteosarcoma 55.87 12.37 29 220433 289 42400584
Rhinovirus infection 55.83 12.37 112 220350 6436 42394437
Migraine 55.69 12.37 31 220431 25383 42375490
Epstein-Barr virus associated lymphoma 54.99 12.37 45 220417 1021 42399852
Cardiac arrest 54.68 12.37 336 220126 108984 42291889
Parainfluenzae virus infection 54.52 12.37 80 220382 3563 42397310
Brain abscess 54.15 12.37 87 220375 4197 42396676
Malignant transformation 54.09 12.37 43 220419 935 42399938
Interstitial lung disease 53.88 12.37 632 219830 77830 42323043
Diabetes mellitus 53.80 12.37 147 220315 59940 42340933
Road traffic accident 53.65 12.37 16 220446 19077 42381796
Adenoviral haemorrhagic cystitis 53.60 12.37 34 220428 509 42400364
Disseminated intravascular coagulation 53.46 12.37 262 220200 24532 42376341
Metabolic acidosis 53.39 12.37 118 220344 51740 42349133
Refractory anaemia with an excess of blasts 53.10 12.37 29 220433 323 42400550
B-cell lymphoma refractory 52.84 12.37 25 220437 200 42400673
End stage renal disease 52.77 12.37 197 220265 16361 42384512
Anger 52.05 12.37 4 220458 13014 42387859
Intestinal perforation 51.45 12.37 148 220314 10726 42390147
Unresponsive to stimuli 51.23 12.37 52 220410 31351 42369522
Plasma cell leukaemia 51.05 12.37 46 220416 1194 42399679
Respiratory depression 50.90 12.37 17 220445 18851 42382022
Coma 50.24 12.37 128 220334 53426 42347447
Peripheral sensory neuropathy 50.23 12.37 128 220334 8634 42392239
Delusion 50.19 12.37 8 220454 14726 42386147
Myasthenia gravis 50.19 12.37 11 220451 16126 42384747
Blood glucose decreased 50.10 12.37 7 220455 14212 42386661
Respiratory arrest 49.97 12.37 44 220418 28380 42372493
Impaired quality of life 49.90 12.37 7 220455 14170 42386703
Nodular regenerative hyperplasia 49.42 12.37 42 220420 1006 42399867
Influenza like illness 49.40 12.37 55 220407 31785 42369088
Enterovirus infection 49.39 12.37 46 220416 1247 42399626
Sleep apnoea syndrome 49.35 12.37 25 220437 21583 42379290
Therapy cessation 49.25 12.37 22 220440 20428 42380445
Musculoskeletal pain 49.14 12.37 60 220402 33280 42367593
Febrile infection 49.13 12.37 66 220396 2705 42398168
Arteriosclerosis 48.89 12.37 16 220446 17973 42382900
Hepatosplenomegaly 48.78 12.37 87 220375 4573 42396300
Acute myocardial infarction 48.63 12.37 147 220315 58018 42342855
COVID-19 pneumonia 48.48 12.37 231 220231 21382 42379491
Burning sensation 48.46 12.37 24 220438 20989 42379884
Malignant genitourinary tract neoplasm 48.39 12.37 15 220447 28 42400845
Prostatic specific antigen increased 47.90 12.37 14 220448 16911 42383962
Polyomavirus-associated nephropathy 47.83 12.37 96 220366 5519 42395354
Pemphigoid 47.37 12.37 3 220459 11464 42389409
Encephalopathy 47.34 12.37 371 220091 40962 42359911
Glioblastoma multiforme 47.12 12.37 38 220424 844 42400029
Rash pruritic 46.91 12.37 63 220399 33540 42367333
Pneumonitis 46.43 12.37 372 220090 41346 42359527
Prescribed overdose 46.41 12.37 6 220456 12921 42387952
Squamous cell carcinoma of skin 46.19 12.37 158 220304 12568 42388305
Emotional distress 46.12 12.37 13 220449 16080 42384793
Delirium 45.89 12.37 130 220332 52389 42348484
Glioma 45.79 12.37 30 220432 476 42400397
Product storage error 45.76 12.37 3 220459 11137 42389736
Poisoning 45.76 12.37 10 220452 14689 42386184
Discomfort 45.60 12.37 38 220424 25181 42375692
Hallucination, visual 45.54 12.37 26 220436 20994 42379879
Cough 45.43 12.37 648 219814 177455 42223418
Primary amyloidosis 45.30 12.37 23 220439 218 42400655
Visual impairment 45.29 12.37 97 220365 43016 42357857
Gastrosplenic fistula 45.20 12.37 16 220446 53 42400820
Hyponatraemia 45.13 12.37 323 220139 101139 42299734
Lip swelling 45.10 12.37 21 220441 19032 42381841
Cardiac disorder 45.10 12.37 118 220344 48814 42352059
Pneumonia viral 45.00 12.37 80 220382 4194 42396679
Liver function test abnormal 44.94 12.37 61 220401 32330 42368543
Immunosuppression 44.89 12.37 120 220342 8333 42392540
Encephalitis viral 44.70 12.37 47 220415 1481 42399392
Abdominal pain 44.46 12.37 705 219757 189766 42211107
Azoospermia 44.32 12.37 30 220432 504 42400369
Hypoaesthesia 43.85 12.37 205 220257 71258 42329615
Meningoencephalitis herpetic 43.84 12.37 39 220423 995 42399878
Stenotrophomonas infection 43.82 12.37 73 220389 3631 42397242
Central nervous system fungal infection 43.80 12.37 28 220434 425 42400448
Respiratory tract infection 43.74 12.37 259 220203 26063 42374810
Hyperbilirubinaemia 43.73 12.37 217 220245 20418 42380455
Blood pressure decreased 43.53 12.37 155 220307 58177 42342696
Hypertension 43.11 12.37 607 219855 166597 42234276
Pneumocystis jirovecii infection 43.08 12.37 63 220399 2797 42398076
Gait inability 43.05 12.37 33 220429 22800 42378073
Gout 42.94 12.37 49 220413 28006 42372867
Recurrent cancer 42.89 12.37 48 220414 1625 42399248
Skin laceration 42.89 12.37 10 220452 14048 42386825
Hepatopulmonary syndrome 42.66 12.37 18 220444 106 42400767
Presyncope 42.66 12.37 32 220430 22355 42378518
Therapeutic response shortened 42.64 12.37 9 220453 13545 42387328
Iron deficiency anaemia 42.40 12.37 8 220454 13031 42387842
Skin discolouration 42.26 12.37 28 220434 20862 42380011
Limb injury 42.04 12.37 11 220451 14294 42386579
Ocular hyperaemia 42.00 12.37 15 220447 15948 42384925
Wound 41.88 12.37 18 220444 17099 42383774
Glycosylated haemoglobin increased 41.87 12.37 8 220454 12916 42387957
B-cell lymphoma 41.85 12.37 84 220378 4829 42396044
Pneumonia respiratory syncytial viral 41.76 12.37 44 220418 1390 42399483
Feeling hot 41.70 12.37 36 220426 23446 42377427
Ventricular fibrillation 41.52 12.37 57 220405 30066 42370807
Neoplasm 41.35 12.37 97 220365 6208 42394665
Capillary leak syndrome 41.32 12.37 60 220402 2647 42398226
Refractory cancer 41.25 12.37 20 220442 170 42400703
Humoral immune defect 41.16 12.37 25 220437 345 42400528
Obliterative bronchiolitis 41.08 12.37 44 220418 1417 42399456
Streptococcal bacteraemia 41.06 12.37 60 220402 2662 42398211
Sopor 41.06 12.37 9 220453 13193 42387680
Bone marrow disorder 41.00 12.37 51 220411 1935 42398938
Paranoia 40.81 12.37 11 220451 14015 42386858
B-cell aplasia 40.69 12.37 18 220444 121 42400752
Systemic candida 40.68 12.37 87 220375 5232 42395641
Ventricular tachycardia 40.64 12.37 58 220404 30102 42370771
5q minus syndrome 40.56 12.37 18 220444 122 42400751
Nasal congestion 40.48 12.37 56 220406 29445 42371428
Condition aggravated 40.47 12.37 1033 219429 259721 42141152
Primary hypogonadism 40.45 12.37 17 220445 99 42400774
Clear cell renal cell carcinoma 40.35 12.37 41 220421 1240 42399633
Dyspnoea exertional 40.32 12.37 129 220333 50019 42350854
Miosis 40.16 12.37 10 220452 13436 42387437
Diabetic ketoacidosis 40.07 12.37 34 220428 22333 42378540
Panic attack 39.96 12.37 5 220457 11040 42389833
Adverse event 39.88 12.37 38 220424 23602 42377271
Hypofibrinogenaemia 39.79 12.37 50 220412 1917 42398956
Hypersomnia 39.73 12.37 13 220449 14605 42386268
Akathisia 39.65 12.37 4 220458 10447 42390426
Gastritis bacterial 39.59 12.37 24 220438 330 42400543
Autoimmune neutropenia 39.34 12.37 24 220438 334 42400539
Meningitis cryptococcal 39.23 12.37 65 220397 3218 42397655
Respiratory distress 39.23 12.37 359 220103 41461 42359412
Arteriosclerosis coronary artery 39.20 12.37 24 220438 18653 42382220
Cardiac murmur 39.14 12.37 9 220453 12766 42388107
Joint stiffness 39.14 12.37 8 220454 12314 42388559
Acute monocytic leukaemia 39.08 12.37 25 220437 380 42400493
Respiratory tract infection fungal 38.98 12.37 33 220429 786 42400087
Chronic graft versus host disease oral 38.74 12.37 25 220437 386 42400487
Hepatitis viral 38.63 12.37 33 220429 796 42400077
Peritonitis pneumococcal 38.51 12.37 12 220450 23 42400850
Respiratory syncytial virus infection 38.45 12.37 102 220360 7050 42393823
T-cell lymphoma 38.34 12.37 38 220424 1115 42399758
Graft versus host disease in eye 38.08 12.37 23 220439 314 42400559
Chronic lymphocytic leukaemia transformation 37.96 12.37 20 220442 206 42400667
Hernia 37.75 12.37 6 220456 11067 42389806
Cytomegalovirus colitis 37.48 12.37 71 220391 3910 42396963
Bacillus infection 37.45 12.37 31 220431 715 42400158
Fear 37.25 12.37 6 220456 10959 42389914
Post-acute COVID-19 syndrome 37.24 12.37 25 220437 414 42400459
Psychomotor hyperactivity 37.21 12.37 6 220456 10952 42389921
Myocardial ischaemia 37.03 12.37 23 220439 17739 42383134
Underdose 37.00 12.37 20 220442 16646 42384227
Hypertriglyceridaemia 36.99 12.37 126 220336 10000 42390873
Serum ferritin increased 36.85 12.37 101 220361 7118 42393755
Thymus enlargement 36.74 12.37 13 220449 43 42400830
Tinnitus 36.71 12.37 58 220404 28880 42371993
Pleural effusion 36.61 12.37 706 219756 96460 42304413
Acute kidney injury 36.59 12.37 1541 218921 365796 42035077
Cholelithiasis 36.58 12.37 40 220422 23306 42377567
Follicular lymphoma 36.53 12.37 25 220437 428 42400445
Neuroblastoma 36.38 12.37 22 220440 301 42400572
Complications of bone marrow transplant 36.29 12.37 20 220442 227 42400646
Neuroblastoma recurrent 36.25 12.37 24 220438 388 42400485
Steroid diabetes 36.16 12.37 58 220404 2794 42398079
Mood altered 36.10 12.37 6 220456 10712 42390161
Impaired work ability 36.10 12.37 9 220453 12082 42388791
Hypertensive crisis 36.01 12.37 5 220457 10201 42390672
Gene mutation 35.59 12.37 45 220417 1736 42399137
Pulmonary toxicity 35.48 12.37 112 220350 8543 42392330
Intentional dose omission 35.26 12.37 3 220459 8983 42391890
Generalised oedema 35.19 12.37 165 220297 15171 42385702
Movement disorder 35.10 12.37 16 220446 14682 42386191
Acute erythroid leukaemia 35.05 12.37 20 220442 244 42400629
Retinitis viral 34.91 12.37 17 220445 146 42400727
Diabetes mellitus inadequate control 34.85 12.37 18 220444 15372 42385501
Pneumonia adenoviral 34.83 12.37 23 220439 370 42400503
Chronic myeloid leukaemia 34.83 12.37 53 220409 2439 42398434
Encephalitis enteroviral 34.79 12.37 18 220444 178 42400695
Stevens-Johnson syndrome 34.75 12.37 38 220424 22140 42378733
Babesiosis 34.68 12.37 19 220443 213 42400660
Coronary artery stenosis 34.54 12.37 6 220456 10373 42390500
Melaena 34.52 12.37 95 220367 38651 42362222
Type 2 diabetes mellitus 34.43 12.37 27 220435 18444 42382429
Full blood count abnormal 34.14 12.37 64 220398 29812 42371061
Troponin increased 34.12 12.37 29 220433 19033 42381840
Aortic stenosis 34.10 12.37 3 220459 8742 42392131
Haematopoietic stem cell mobilisation 34.08 12.37 22 220440 340 42400533
Eye disorder 33.99 12.37 9 220453 11603 42389270
Acute respiratory distress syndrome 33.79 12.37 269 220193 29839 42371034
Vomiting 33.74 12.37 1193 219269 288530 42112343
Rash macular 33.68 12.37 23 220439 16868 42384005
Pneumomediastinum 33.68 12.37 59 220403 3057 42397816
Limb discomfort 33.58 12.37 12 220450 12755 42388118
Guillain-Barre syndrome 33.54 12.37 98 220364 7165 42393708
Small intestinal perforation 33.51 12.37 57 220405 2884 42397989
Erectile dysfunction 33.48 12.37 48 220414 24865 42376008
Swelling face 33.30 12.37 57 220405 27497 42373376
Gallbladder oedema 33.21 12.37 19 220443 233 42400640
Blister 33.10 12.37 57 220405 27433 42373440
Autoimmune lymphoproliferative syndrome 33.07 12.37 18 220444 199 42400674
Benign prostatic hyperplasia 33.06 12.37 36 220426 21016 42379857
Salivary hypersecretion 32.96 12.37 8 220454 10935 42389938
Anaphylactic reaction 32.95 12.37 112 220350 42631 42358242
Localised infection 32.93 12.37 34 220428 20339 42380534
Drug level increased 32.78 12.37 53 220409 26147 42374726
Streptococcal infection 32.51 12.37 87 220375 6045 42394828
Idiopathic pneumonia syndrome 32.45 12.37 24 220438 467 42400406
Blood pressure diastolic decreased 32.41 12.37 7 220455 10368 42390505
Enterococcal sepsis 32.21 12.37 46 220416 1998 42398875
Papilloma viral infection 32.14 12.37 28 220434 694 42400179
Drug effective for unapproved indication 32.08 12.37 91 220371 6542 42394331
Hepatic enzyme increased 31.98 12.37 125 220337 45659 42355214
Ototoxicity 31.86 12.37 49 220413 2276 42398597
Eye pain 31.61 12.37 25 220437 17005 42383868
Dysphonia 31.58 12.37 62 220400 28388 42372485
Epistaxis 31.55 12.37 209 220253 66617 42334256
Device related sepsis 31.38 12.37 65 220397 3822 42397051
Blood creatinine increased 31.38 12.37 391 220071 109612 42291261
Genitourinary tract neoplasm 31.30 12.37 9 220453 11 42400862
Pulmonary veno-occlusive disease 31.26 12.37 26 220436 604 42400269
Plasmablastic lymphoma 31.08 12.37 26 220436 609 42400264
Cerebral aspergillosis 31.01 12.37 42 220420 1735 42399138
Pulmonary haemorrhage 30.98 12.37 129 220333 11268 42389605
T-cell lymphoma stage IV 30.95 12.37 16 220446 158 42400715
Anaphylactic shock 30.92 12.37 46 220416 23471 42377402
Pulmonary arteriopathy 30.89 12.37 13 220449 76 42400797
H1N1 influenza 30.88 12.37 34 220428 1130 42399743
Acne 30.84 12.37 16 220446 13628 42387245
Chronic graft versus host disease in eye 30.74 12.37 19 220443 271 42400602
Acute lymphocytic leukaemia refractory 30.69 12.37 15 220447 130 42400743
Blood immunoglobulin G decreased 30.64 12.37 48 220414 2266 42398607
IVth nerve paralysis 30.59 12.37 25 220437 566 42400307
Bacteroides bacteraemia 30.58 12.37 10 220452 24 42400849
Transformation to acute myeloid leukaemia 30.58 12.37 33 220429 1072 42399801
Herpes simplex encephalitis 30.51 12.37 21 220441 363 42400510
Achromobacter infection 30.44 12.37 16 220446 164 42400709
Traumatic lung injury 30.42 12.37 36 220426 1296 42399577
Dermatitis atopic 30.41 12.37 13 220449 12391 42388482
Hypotension 30.41 12.37 1059 219403 256572 42144301
Ageusia 30.37 12.37 11 220451 11594 42389279
Splenic candidiasis 30.34 12.37 13 220449 80 42400793
Primitive neuroectodermal tumour 30.34 12.37 13 220449 80 42400793
Paraparesis 30.30 12.37 45 220417 2026 42398847
Blood urea increased 30.28 12.37 79 220383 32714 42368159
Tendonitis 30.26 12.37 7 220455 9887 42390986
Marginal zone lymphoma recurrent 30.21 12.37 12 220450 59 42400814
Ill-defined disorder 30.13 12.37 165 220297 16131 42384742
Device malfunction 30.10 12.37 13 220449 12314 42388559
Central nervous system mass 30.08 12.37 29 220433 822 42400051
Graft complication 30.02 12.37 27 220435 699 42400174
Cardiac dysfunction 30.02 12.37 59 220403 3340 42397533
Nasal cavity cancer 29.89 12.37 17 220445 206 42400667
Out of specification test results 29.89 12.37 11 220451 42 42400831
Therapy responder 29.62 12.37 16 220446 174 42400699
Dementia 29.59 12.37 25 220437 16455 42384418
SARS-CoV-2 test negative 29.54 12.37 41 220421 1734 42399139
Platelet transfusion 29.50 12.37 40 220422 1654 42399219
Bacillus bacteraemia 29.47 12.37 16 220446 176 42400697
C-reactive protein abnormal 29.44 12.37 6 220456 9255 42391618
Electrocardiogram abnormal 29.43 12.37 8 220454 10137 42390736
Haemorrhage 29.31 12.37 188 220274 60375 42340498
Skin fissures 29.28 12.37 7 220455 9669 42391204
Empyema 29.28 12.37 66 220396 4114 42396759
Respirovirus test positive 29.26 12.37 12 220450 65 42400808
Cardiogenic shock 29.13 12.37 91 220371 35549 42365324
Congenital cardiovascular anomaly 29.08 12.37 16 220446 181 42400692
Escherichia test positive 29.01 12.37 35 220427 1286 42399587
Muscle rigidity 29.00 12.37 13 220449 12046 42388827
Contraindicated product administered 28.99 12.37 54 220408 25218 42375655
Secretion discharge 28.76 12.37 3 220459 7632 42393241
Thirst 28.75 12.37 6 220456 9102 42391771
Hip fracture 28.71 12.37 17 220445 13455 42387418
Meningeal neoplasm 28.71 12.37 13 220449 93 42400780
Drug eruption 28.57 12.37 47 220415 23028 42377845
Viral test positive 28.54 12.37 17 220445 226 42400647
Myelitis transverse 28.46 12.37 35 220427 1312 42399561
Abdominal lymphadenopathy 28.45 12.37 31 220431 1018 42399855
Eosinophilia 28.32 12.37 82 220380 32817 42368056
Obstructive airways disorder 28.32 12.37 53 220409 24706 42376167
Metastasis 28.30 12.37 70 220392 4635 42396238
Escherichia bacteraemia 28.26 12.37 74 220388 5075 42395798
Myeloid leukaemia 28.16 12.37 22 220440 466 42400407
Viraemia 28.14 12.37 40 220422 1730 42399143
Wall motion score index abnormal 28.10 12.37 28 220434 827 42400046
Enterobacter sepsis 28.03 12.37 30 220432 965 42399908
Bronchitis 28.02 12.37 137 220325 47064 42353809
Gynaecomastia 28.01 12.37 15 220447 12552 42388321
Lower respiratory tract infection fungal 27.96 12.37 24 220438 583 42400290
Paraesthesia 27.94 12.37 244 220218 73215 42327658
Blindness cortical 27.92 12.37 22 220440 472 42400401
Lethargy 27.89 12.37 136 220326 46754 42354119
Diffuse large B-cell lymphoma stage IV 27.81 12.37 23 220439 530 42400343
Chromaturia 27.80 12.37 25 220437 15964 42384909
Organic brain syndrome 27.78 12.37 19 220443 325 42400548
Hyperviscosity syndrome 27.73 12.37 18 220444 281 42400592
Hypercholesterolaemia 27.68 12.37 16 220446 12833 42388040
Blood loss anaemia 27.65 12.37 8 220454 9728 42391145
Rhabdomyosarcoma recurrent 27.63 12.37 14 220448 132 42400741
Adenoviral hepatitis 27.59 12.37 23 220439 536 42400337
Hypopnoea 27.49 12.37 4 220458 7878 42392995
Mood swings 27.48 12.37 6 220456 8820 42392053
Large intestine polyp 27.46 12.37 7 220455 9258 42391615
Metastases to spleen 27.34 12.37 22 220440 487 42400386
Pulmonary vascular disorder 27.30 12.37 25 220437 663 42400210
Urinary tract infection 27.16 12.37 356 220106 98928 42301945
Human herpesvirus 8 infection 27.07 12.37 36 220426 1461 42399412
Product administration error 27.04 12.37 33 220429 18310 42382563
Mass 27.04 12.37 103 220359 8636 42392237
Aphasia 26.93 12.37 215 220247 23868 42377005
Airway remodelling 26.89 12.37 28 220434 872 42400001
Drug level decreased 26.89 12.37 9 220453 9968 42390905
Joint range of motion decreased 26.89 12.37 4 220458 7749 42393124
Hypothyroidism 26.87 12.37 81 220381 32003 42368870
Hypoalbuminaemia 26.84 12.37 155 220307 15455 42385418
Microangiopathy 26.72 12.37 38 220424 1644 42399229
Actinomycosis 26.71 12.37 23 220439 561 42400312
Sertoli-cell-only syndrome 26.62 12.37 10 220452 41 42400832
Meningitis enteroviral 26.59 12.37 9 220453 25 42400848
Device related thrombosis 26.51 12.37 35 220427 1410 42399463
Fibrinous bronchitis 26.46 12.37 13 220449 114 42400759
Acinetobacter infection 26.43 12.37 36 220426 1495 42399378
Colitis 26.36 12.37 362 220100 46210 42354663
Chronic lymphocytic leukaemia refractory 26.36 12.37 12 220450 87 42400786
BK polyomavirus test positive 26.32 12.37 11 220451 63 42400810
Cytomegalovirus enteritis 26.19 12.37 24 220438 637 42400236
Hepatosplenic candidiasis 26.08 12.37 16 220446 225 42400648
Hemianopia 26.08 12.37 28 220434 904 42399969
Dry eye 26.07 12.37 25 220437 15481 42385392
Dystonia 26.06 12.37 17 220445 12773 42388100
Intentional product use issue 26.06 12.37 519 219943 71314 42329559
Hyperpyrexia 26.04 12.37 57 220405 3483 42397390
Pneumonia aspiration 26.03 12.37 152 220310 49926 42350947
T-lymphocyte count decreased 25.83 12.37 17 220445 272 42400601
Gastrointestinal haemorrhage 25.80 12.37 353 220109 97373 42303500
Aspiration bone marrow abnormal 25.71 12.37 13 220449 122 42400751
CD4 lymphocytes decreased 25.65 12.37 40 220422 1881 42398992
Corynebacterium infection 25.55 12.37 27 220435 856 42400017
B precursor type acute leukaemia 25.54 12.37 16 220446 234 42400639
Fat embolism syndrome 25.50 12.37 11 220451 69 42400804
Eye swelling 25.46 12.37 15 220447 11905 42388968
Immunodeficiency common variable 25.46 12.37 17 220445 279 42400594
Urinary retention 25.36 12.37 122 220340 42092 42358781
Paresis 25.36 12.37 46 220416 2450 42398423
Restless legs syndrome 25.35 12.37 9 220453 9605 42391268
Juvenile melanoma benign 25.24 12.37 11 220451 71 42400802
Diffuse alopecia 25.16 12.37 12 220450 98 42400775
Leukaemic infiltration 25.10 12.37 14 220448 163 42400710
Chronic lymphocytic leukaemia 25.08 12.37 68 220394 4761 42396112
Atopy 25.04 12.37 28 220434 947 42399926
Prescribed underdose 24.85 12.37 11 220451 10271 42390602
Proctalgia 24.81 12.37 87 220375 7006 42393867
Angina pectoris 24.81 12.37 87 220375 32809 42368064
Rotavirus infection 24.78 12.37 21 220441 501 42400372
Pneumatosis intestinalis 24.77 12.37 67 220395 4685 42396188
Musculoskeletal discomfort 24.77 12.37 9 220453 9467 42391406
Coronary artery occlusion 24.70 12.37 13 220449 10984 42389889
Spinal column injury 24.68 12.37 23 220439 624 42400249
Facial paresis 24.67 12.37 53 220409 3197 42397676
Disturbance in attention 24.59 12.37 76 220386 29790 42371083
Poor venous access 24.56 12.37 4 220458 7248 42393625
Body temperature decreased 24.51 12.37 23 220439 14390 42386483
Secondary immunodeficiency 24.45 12.37 26 220436 830 42400043
Schizophrenia 24.40 12.37 12 220450 10538 42390335
Pneumonia pseudomonal 24.38 12.37 68 220394 4841 42396032
Pericardial effusion 24.33 12.37 245 220217 29030 42371843
Fluid retention 24.27 12.37 83 220379 31536 42369337
Scrotal cellulitis 24.25 12.37 11 220451 79 42400794
Myeloproliferative neoplasm 24.18 12.37 25 220437 772 42400101
Pleuroparenchymal fibroelastosis 24.18 12.37 13 220449 140 42400733
Disseminated toxoplasmosis 24.15 12.37 16 220446 259 42400614
Granulomatosis with polyangiitis 24.14 12.37 34 220428 1458 42399415
Giardiasis 24.12 12.37 21 220441 520 42400353
Increased appetite 24.07 12.37 8 220454 8898 42391975
Ejection fraction decreased 24.05 12.37 196 220266 21891 42378982
Prostate cancer 24.01 12.37 134 220328 44509 42356364
Chylothorax 24.00 12.37 30 220432 1144 42399729
Laboratory test abnormal 23.88 12.37 52 220410 22926 42377947
Rotator cuff syndrome 23.78 12.37 3 220459 6583 42394290
Metastases to bone marrow 23.76 12.37 21 220441 531 42400342
Malignant syphilis 23.75 12.37 9 220453 38 42400835
Metastases to meninges 23.67 12.37 39 220423 1922 42398951
Blood potassium increased 23.66 12.37 37 220425 18499 42382374
Epstein-Barr virus test positive 23.59 12.37 23 220439 661 42400212
Therapeutic response decreased 23.59 12.37 294 220168 36718 42364155
Splenomegaly 23.52 12.37 160 220302 16887 42383986
Organising pneumonia 23.49 12.37 89 220373 7443 42393430
Ischaemic cardiomyopathy 23.48 12.37 3 220459 6519 42394354
Peripheral motor neuropathy 23.35 12.37 42 220420 2222 42398651
Pulmonary mucormycosis 23.31 12.37 33 220429 1422 42399451
Central nervous system leukaemia 23.29 12.37 18 220444 375 42400498
Fungal oesophagitis 23.22 12.37 19 220443 431 42400442
Superior sagittal sinus thrombosis 23.19 12.37 17 220445 326 42400547
Subdural hygroma 23.15 12.37 19 220443 433 42400440
Hyperthyroidism 23.10 12.37 24 220438 14317 42386556
Emphysematous cholecystitis 23.04 12.37 11 220451 90 42400783
Lymphoplasmacytoid lymphoma/immunocytoma recurrent 22.95 12.37 8 220454 25 42400848
Chronic hepatitis B 22.91 12.37 12 220450 122 42400751
Dizziness postural 22.89 12.37 6 220456 7789 42393084
Oroantral fistula 22.88 12.37 14 220448 196 42400677
Arrhythmogenic right ventricular dysplasia 22.86 12.37 9 220453 43 42400830
Abdominal neoplasm 22.85 12.37 19 220443 441 42400432
Chronic graft versus host disease in intestine 22.75 12.37 19 220443 444 42400429
Skin abrasion 22.70 12.37 7 220455 8168 42392705
Squamous cell carcinoma of the oral cavity 22.69 12.37 16 220446 288 42400585
Candida pneumonia 22.68 12.37 24 220438 762 42400111
Faeces discoloured 22.64 12.37 33 220429 16981 42383892
Molluscum contagiosum 22.59 12.37 17 220445 340 42400533
Haematoma 22.58 12.37 72 220390 27951 42372922
Anal inflammation 22.55 12.37 41 220421 2188 42398685
Disorientation 22.54 12.37 104 220358 36285 42364588
Carbohydrate antigen 15-3 increased 22.51 12.37 10 220452 68 42400805
Metastatic lymphoma 22.50 12.37 18 220444 395 42400478
Emotional disorder 22.50 12.37 3 220459 6311 42394562
Respiratory tract congestion 22.38 12.37 6 220456 7672 42393201
Renal tubular injury 22.31 12.37 36 220426 1743 42399130
Leukaemia cutis 22.26 12.37 10 220452 70 42400803
Neurofibrosarcoma 22.22 12.37 9 220453 47 42400826
Transplantation complication 22.21 12.37 15 220447 251 42400622
Blood pressure abnormal 22.19 12.37 12 220450 9986 42390887
Acute promyelocytic leukaemia 22.18 12.37 23 220439 713 42400160
Blood potassium decreased 22.13 12.37 45 220417 20339 42380534
Neuroendocrine carcinoma of the skin 22.08 12.37 26 220436 931 42399942
Throat tightness 22.08 12.37 11 220451 9588 42391285
Neuralgia 22.02 12.37 64 220398 25583 42375290
Cardiac septal defect 22.01 12.37 26 220436 934 42399939
Cardiovascular disorder 21.95 12.37 22 220440 13343 42387530
Pathogen resistance 21.89 12.37 117 220345 11333 42389540
Myoclonus 21.84 12.37 34 220428 17031 42383842
Viral vasculitis 21.78 12.37 11 220451 103 42400770
Opportunistic infection 21.77 12.37 38 220424 1963 42398910
Spermatozoa abnormal 21.76 12.37 9 220453 50 42400823
Feeling cold 21.71 12.37 21 220441 12952 42387921
Diverticulitis 21.69 12.37 54 220408 22719 42378154
Medulloblastoma recurrent 21.60 12.37 11 220451 105 42400768
Infection in an immunocompromised host 21.59 12.37 27 220435 1030 42399843
JC virus CSF test positive 21.57 12.37 12 220450 139 42400734
Vaccination failure 21.56 12.37 32 220430 1440 42399433
Productive cough 21.56 12.37 167 220295 51400 42349473
Gastric disorder 21.51 12.37 18 220444 11904 42388969
Anaplastic large cell lymphoma T- and null-cell types 21.49 12.37 12 220450 140 42400733
Herpes zoster infection neurological 21.49 12.37 6 220456 6 42400867
Micturition urgency 21.42 12.37 18 220444 11880 42388993
Haematemesis 21.37 12.37 82 220380 30117 42370756
Stenotrophomonas sepsis 21.37 12.37 13 220449 180 42400693
Anaplastic large cell lymphoma T- and null-cell types recurrent 21.33 12.37 9 220453 53 42400820
Aspergillus test positive 21.29 12.37 22 220440 679 42400194
Central nervous system vasculitis 21.27 12.37 21 220441 613 42400260
Inflammatory pseudotumour 21.25 12.37 8 220454 33 42400840
Basal cell carcinoma 21.24 12.37 195 220267 22538 42378335
Mucoepidermoid carcinoma 21.07 12.37 7 220455 18 42400855
Blood HIV RNA increased 21.06 12.37 33 220429 1558 42399315
Polymyositis 21.05 12.37 35 220427 1738 42399135
Intervertebral disc degeneration 21.02 12.37 6 220456 7361 42393512
Orthostatic hypotension 21.00 12.37 84 220378 30486 42370387
High-grade B-cell lymphoma 21.00 12.37 13 220449 186 42400687
Left ventricular dysfunction 20.96 12.37 116 220346 11385 42389488
Neutropenic infection 20.94 12.37 36 220426 1837 42399036
Endocarditis bacterial 20.94 12.37 29 220433 1224 42399649
Tidal volume decreased 20.88 12.37 8 220454 35 42400838
Fungal sepsis 20.85 12.37 27 220435 1067 42399806
Foetal exposure during pregnancy 20.83 12.37 151 220311 47160 42353713
Throat irritation 20.79 12.37 22 220440 13014 42387859
Meningitis enterococcal 20.78 12.37 12 220450 150 42400723
Hospice care 20.75 12.37 9 220453 8504 42392369
Acanthamoeba infection 20.74 12.37 19 220443 504 42400369
Tenderness 20.70 12.37 10 220452 8873 42392000
Tachycardia 20.69 12.37 383 220079 100704 42300169
Spinal stenosis 20.68 12.37 4 220458 6402 42394471
Haemolytic uraemic syndrome 20.66 12.37 42 220420 2437 42398436
Drug level above therapeutic 20.59 12.37 3 220459 5903 42394970
Enterobacter infection 20.56 12.37 47 220415 2957 42397916
Palatal disorder 20.53 12.37 13 220449 194 42400679
Ventricular hypokinesia 20.37 12.37 80 220382 6804 42394069
Post procedural complication 20.36 12.37 21 220441 12569 42388304
Blood test abnormal 20.34 12.37 22 220440 12884 42387989
Neurological decompensation 20.33 12.37 54 220408 3735 42397138
Blood iron decreased 20.28 12.37 4 220458 6314 42394559
Hypokinesia 20.28 12.37 13 220449 9858 42391015
Mydriasis 20.25 12.37 10 220452 8760 42392113
T-cell type acute leukaemia 20.24 12.37 13 220449 199 42400674
Amyloidosis 20.18 12.37 41 220421 2378 42398495
Thinking abnormal 20.12 12.37 6 220456 7155 42393718
Influenza 20.05 12.37 215 220247 61960 42338913
Haemoptysis 20.01 12.37 148 220314 46019 42354854
Procedural pain 20.00 12.37 3 220459 5776 42395097
Asphyxia 19.98 12.37 9 220453 8317 42392556
Acute polyneuropathy 19.86 12.37 13 220449 206 42400667
Cytokine storm 19.85 12.37 24 220438 884 42399989
Blood bilirubin increased 19.83 12.37 318 220144 41934 42358939
Transitional cell carcinoma 19.78 12.37 43 220419 2615 42398258
Injection site rash 19.69 12.37 3 220459 5709 42395164
Blood glucose abnormal 19.65 12.37 6 220456 7047 42393826
Norovirus infection 19.65 12.37 22 220440 745 42400128
Varicella 19.65 12.37 37 220425 2028 42398845
Blood urine present 19.63 12.37 19 220443 11714 42389159
Glomerulonephritis rapidly progressive 19.59 12.37 24 220438 896 42399977
Adenocarcinoma gastric 19.59 12.37 30 220432 1388 42399485
Left ventricular hypertrophy 19.52 12.37 12 220450 9307 42391566
Paraneoplastic pemphigus 19.46 12.37 9 220453 68 42400805
Metastases to skin 19.41 12.37 19 220443 549 42400324
Speech disorder 19.39 12.37 81 220381 29040 42371833
Uveitis 19.28 12.37 12 220450 9246 42391627
Viral sinusitis 19.24 12.37 9 220453 70 42400803
Hepatic candidiasis 19.24 12.37 9 220453 70 42400803
Antithrombin III decreased 19.24 12.37 19 220443 555 42400318
Immunoglobulins decreased 19.19 12.37 25 220437 994 42399879
Cerebrosclerosis 19.17 12.37 7 220455 26 42400847
Salivary gland cancer 19.11 12.37 15 220447 320 42400553
Blood phosphorus increased 19.03 12.37 22 220440 12503 42388370
Adult T-cell lymphoma/leukaemia 19.01 12.37 12 220450 178 42400695
Tendon rupture 18.99 12.37 9 220453 8074 42392799
Disseminated cytomegaloviral infection 18.99 12.37 14 220448 271 42400602
Ameloblastoma 18.98 12.37 10 220452 103 42400770
Combined immunodeficiency 18.98 12.37 10 220452 103 42400770
Device occlusion 18.96 12.37 10 220452 8440 42392433
Upper limb fracture 18.96 12.37 3 220459 5553 42395320
Glomerulosclerosis 18.94 12.37 23 220439 851 42400022
Eosinophilic myocarditis 18.90 12.37 29 220433 1344 42399529
Gastrointestinal wall thickening 18.82 12.37 34 220428 1805 42399068
Intraocular pressure increased 18.80 12.37 5 220457 6428 42394445
Lymphadenitis viral 18.77 12.37 7 220455 28 42400845
Peripheral arterial occlusive disease 18.73 12.37 6 220456 6832 42394041
Metastases to testicle 18.71 12.37 9 220453 75 42400798
Forced expiratory volume decreased 18.70 12.37 8 220454 7622 42393251
Enterobacter bacteraemia 18.66 12.37 19 220443 576 42400297
Crying 18.63 12.37 5 220457 6389 42394484
Oligohydramnios 18.63 12.37 16 220446 389 42400484
Delayed engraftment 18.57 12.37 10 220452 108 42400765
Bradykinesia 18.41 12.37 3 220459 5433 42395440
Diverticulum 18.33 12.37 8 220454 7533 42393340
Splenic lesion 18.30 12.37 15 220447 341 42400532
Acute hepatitis B 18.30 12.37 13 220449 237 42400636
Activated partial thromboplastin time prolonged 18.23 12.37 34 220428 15869 42385004
Pleural mass 18.22 12.37 9 220453 80 42400793
Anaplastic large-cell lymphoma 18.22 12.37 9 220453 80 42400793
Tooth deposit 18.22 12.37 9 220453 80 42400793
Choking 18.21 12.37 5 220457 6293 42394580
Cancer fatigue 18.18 12.37 12 220450 193 42400680
Hypoproteinaemia 18.16 12.37 43 220419 2769 42398104
Lymphocytosis 18.13 12.37 45 220417 2986 42397887
Intestinal atresia 18.12 12.37 9 220453 81 42400792
West Nile viral infection 18.06 12.37 23 220439 894 42399979
Chronic myelomonocytic leukaemia 18.05 12.37 21 220441 742 42400131
Morganella infection 18.04 12.37 19 220443 600 42400273
Low density lipoprotein increased 18.03 12.37 3 220459 5352 42395521
Viral cardiomyopathy 18.03 12.37 7 220455 32 42400841
Blood uric acid increased 18.03 12.37 33 220429 15514 42385359
Peripheral T-cell lymphoma unspecified stage IV 18.03 12.37 7 220455 32 42400841
Chromosome analysis abnormal 18.02 12.37 12 220450 196 42400677
Light chain disease 17.97 12.37 11 220451 154 42400719
Hiatus hernia 17.96 12.37 11 220451 8549 42392324
Retching 17.93 12.37 9 220453 7812 42393061
Diaphragm muscle weakness 17.91 12.37 11 220451 155 42400718
Corticobasal degeneration 17.90 12.37 6 220456 16 42400857
Ureteric compression 17.90 12.37 14 220448 297 42400576
Wrong product administered 17.89 12.37 5 220457 6221 42394652
Adenocarcinoma of colon 17.85 12.37 52 220410 3795 42397078
Keratopathy 17.85 12.37 20 220442 678 42400195
Retinal haemorrhage 17.85 12.37 68 220394 5702 42395171
Herpes zoster reactivation 17.83 12.37 16 220446 413 42400460
Mania 17.74 12.37 17 220445 10530 42390343
Heparin-induced thrombocytopenia 17.70 12.37 6 220456 6591 42394282
Pneumonia mycoplasmal 17.68 12.37 21 220441 759 42400114
Streptococcal sepsis 17.68 12.37 34 220428 1894 42398979
Hepatic vein occlusion 17.66 12.37 13 220449 251 42400622
Exophthalmos 17.66 12.37 22 220440 836 42400037
Hepatic cancer 17.65 12.37 11 220451 8469 42392404
Inhibin B 17.64 12.37 6 220456 17 42400856
Tooth development disorder 17.64 12.37 6 220456 17 42400856
Herpes oesophagitis 17.61 12.37 11 220451 160 42400713
Pancreatic carcinoma 17.59 12.37 14 220448 9492 42391381
Pneumaturia 17.58 12.37 8 220454 58 42400815
Hepatic infection fungal 17.57 12.37 13 220449 253 42400620
Focal nodular hyperplasia 17.55 12.37 11 220451 161 42400712
Cataract 17.49 12.37 90 220372 30514 42370359
Blood pressure diastolic abnormal 17.47 12.37 5 220457 6123 42394750
Retroperitoneal lymphadenopathy 17.38 12.37 24 220438 1010 42399863
Altered state of consciousness 17.32 12.37 85 220377 29174 42371699
Mental impairment 17.28 12.37 23 220439 12294 42388579
Metastases to lymph nodes 17.18 12.37 69 220393 5929 42394944
Pneumoperitoneum 17.16 12.37 38 220424 2340 42398533
Enterovesical fistula 17.15 12.37 23 220439 941 42399932
Dysstasia 17.15 12.37 29 220433 14057 42386816
Hepatic amoebiasis 17.13 12.37 8 220454 62 42400811
Ureteric dilatation 17.11 12.37 12 220450 214 42400659
Adenoviral upper respiratory infection 17.08 12.37 4 220458 0 42400873
Inappropriate antidiuretic hormone secretion 17.06 12.37 145 220317 16396 42384477
Leukaemia 17.02 12.37 67 220395 5705 42395168
Aortic arteriosclerosis 16.95 12.37 3 220459 5117 42395756
Cellulitis gangrenous 16.94 12.37 13 220449 268 42400605
Angioimmunoblastic T-cell lymphoma recurrent 16.92 12.37 6 220456 20 42400853
Kidney fibrosis 16.90 12.37 41 220421 2681 42398192
Disorder of orbit 16.89 12.37 9 220453 95 42400778
Product use issue 16.84 12.37 518 219944 76233 42324640
Blood culture positive 16.84 12.37 61 220401 4992 42395881
Upper gastrointestinal haemorrhage 16.81 12.37 90 220372 30209 42370664
Human metapneumovirus test positive 16.81 12.37 9 220453 96 42400777
Rib fracture 16.81 12.37 38 220424 16533 42384340
Kidney infection 16.75 12.37 7 220455 6763 42394110
Foot deformity 16.71 12.37 3 220459 5065 42395808
Appendicitis 16.58 12.37 53 220409 20560 42380313
Respiratory acidosis 16.57 12.37 6 220456 6325 42394548
Vascular access complication 16.56 12.37 15 220447 392 42400481
Breath sounds abnormal 16.54 12.37 23 220439 12070 42388803
Disseminated cryptococcosis 16.50 12.37 33 220429 1892 42398981
Precursor T-lymphoblastic lymphoma/leukaemia 16.48 12.37 7 220455 42 42400831
Personality change due to a general medical condition 16.48 12.37 7 220455 42 42400831
Pneumonia bacterial 16.42 12.37 138 220324 15554 42385319
General physical health deterioration 16.39 12.37 628 219834 150618 42250255
Gingival pain 16.36 12.37 12 220450 8482 42392391
Bacterial disease carrier 16.34 12.37 19 220443 671 42400202
Gingivitis ulcerative 16.29 12.37 12 220450 232 42400641
Helicobacter sepsis 16.28 12.37 6 220456 23 42400850
Oesophageal candidiasis 16.28 12.37 65 220397 5570 42395303
Bone lesion 16.23 12.37 47 220415 3419 42397454
Therapeutic response unexpected 16.23 12.37 21 220441 11360 42389513
Cerebral cavernous malformation 16.21 12.37 7 220455 44 42400829
Poor quality sleep 16.13 12.37 15 220447 9425 42391448
Sphingomonas paucimobilis infection 16.08 12.37 7 220455 45 42400828
Inflammatory myofibroblastic tumour 15.98 12.37 10 220452 146 42400727
Sinus bradycardia 15.95 12.37 33 220429 14820 42386053
Ileus paralytic 15.94 12.37 80 220382 7561 42393312
Basophilia 15.91 12.37 5 220457 10 42400863
Hepatomegaly 15.90 12.37 110 220352 11675 42389198
Clostridium colitis 15.89 12.37 29 220433 1552 42399321
Ureaplasma infection 15.88 12.37 18 220444 618 42400255
Gastrointestinal mucosal disorder 15.88 12.37 16 220446 479 42400394
Rash erythematous 15.84 12.37 99 220363 31992 42368881
Lymphoplasmacytoid lymphoma/immunocytoma 15.83 12.37 7 220455 47 42400826
Drug level below therapeutic 15.82 12.37 7 220455 6538 42394335
Papilloedema 15.81 12.37 45 220417 3241 42397632
Mucosal toxicity 15.81 12.37 13 220449 297 42400576
Kidney transplant rejection 15.80 12.37 13 220449 8670 42392203
Ankle fracture 15.79 12.37 3 220459 4863 42396010
Acute lung injury 15.78 12.37 29 220433 1560 42399313
Lung adenocarcinoma 15.76 12.37 62 220400 5277 42395596
Toxic cardiomyopathy 15.71 12.37 15 220447 420 42400453
Personality change 15.70 12.37 5 220457 5714 42395159
Liver function test increased 15.68 12.37 52 220410 19946 42380927
Pruritus allergic 15.58 12.37 14 220448 362 42400511
Parasitic gastroenteritis 15.58 12.37 10 220452 153 42400720
Cystitis escherichia 15.55 12.37 11 220451 199 42400674
Positron emission tomogram abnormal 15.55 12.37 11 220451 199 42400674
Toxic leukoencephalopathy 15.54 12.37 19 220443 708 42400165
Acute leukaemia 15.53 12.37 25 220437 1208 42399665
Foetal growth abnormality 15.53 12.37 6 220456 27 42400846
Double hit lymphoma 15.53 12.37 6 220456 27 42400846
Hippocampal sclerosis 15.52 12.37 10 220452 154 42400719
Acute generalised exanthematous pustulosis 15.48 12.37 13 220449 8582 42392291
Venous thrombosis 15.44 12.37 51 220411 3984 42396889
Product preparation error 15.39 12.37 3 220459 4775 42396098
Pulmonary hypoplasia 15.38 12.37 16 220446 498 42400375
Gastroenteritis adenovirus 15.32 12.37 11 220451 204 42400669
Ileal perforation 15.28 12.37 23 220439 1048 42399825
Germ cell cancer 15.21 12.37 9 220453 118 42400755
Retroperitoneal mass 15.21 12.37 9 220453 118 42400755
Head discomfort 15.17 12.37 4 220458 5173 42395700
Refractory cytopenia with unilineage dysplasia 15.14 12.37 16 220446 507 42400366
Lymphocyte adoptive therapy 15.14 12.37 8 220454 83 42400790
Metastases to retroperitoneum 15.13 12.37 12 220450 260 42400613
Catarrh 15.12 12.37 6 220456 5980 42394893
Gastrointestinal mucormycosis 15.11 12.37 14 220448 377 42400496
Aspiration 15.09 12.37 45 220417 17841 42383032
Herpes simplex reactivation 15.04 12.37 16 220446 511 42400362
Spirometry abnormal 15.04 12.37 4 220458 5142 42395731
Splenic marginal zone lymphoma 15.02 12.37 6 220456 30 42400843
Toxocariasis 15.02 12.37 6 220456 30 42400843
Phlebitis infective 15.02 12.37 9 220453 121 42400752
Lentigo 14.99 12.37 20 220442 814 42400059
Immunodeficiency 14.98 12.37 76 220386 7214 42393659
Brain stem syndrome 14.97 12.37 18 220444 659 42400214
Vascular device infection 14.95 12.37 67 220395 6043 42394830
Peripheral sensorimotor neuropathy 14.94 12.37 32 220430 1926 42398947
CSF protein increased 14.94 12.37 20 220442 817 42400056
Meningitis tuberculous 14.93 12.37 18 220444 661 42400212
T-cell prolymphocytic leukaemia 14.90 12.37 7 220455 55 42400818
Blood pressure systolic abnormal 14.88 12.37 5 220457 5523 42395350
Mucosal disorder 14.87 12.37 34 220428 2140 42398733
Clostridial infection 14.85 12.37 49 220413 3825 42397048
Hyperleukocytosis 14.85 12.37 38 220424 2570 42398303
Angiocentric lymphoma 14.79 12.37 16 220446 521 42400352
Meningitis viral 14.74 12.37 23 220439 1082 42399791
Bronchiectasis 14.73 12.37 46 220416 17973 42382900
VIth nerve paralysis 14.67 12.37 21 220441 914 42399959
Prostate cancer metastatic 14.65 12.37 8 220454 6621 42394252
Bordetella infection 14.62 12.37 10 220452 171 42400702
Hepatitis D 14.59 12.37 7 220455 58 42400815
Chromosomal mutation 14.56 12.37 6 220456 33 42400840
Glottis carcinoma 14.49 12.37 5 220457 15 42400858
Gallbladder adenocarcinoma 14.49 12.37 5 220457 15 42400858
Pulmonary congestion 14.44 12.37 38 220424 15692 42385181
Premature ageing 14.43 12.37 8 220454 92 42400781
Injection site reaction 14.41 12.37 38 220424 15683 42385190
Cystitis noninfective 14.38 12.37 16 220446 538 42400335
Trichosporon infection 14.38 12.37 21 220441 931 42399942
Abnormal loss of weight 14.34 12.37 4 220458 4983 42395890
Parasitic pneumonia 14.27 12.37 6 220456 35 42400838
Precursor T-lymphoblastic lymphoma/leukaemia recurrent 14.26 12.37 5 220457 16 42400857
Inhibiting antibodies 14.26 12.37 5 220457 16 42400857
Intervertebral disc protrusion 14.23 12.37 22 220440 11050 42389823
Glaucoma 14.22 12.37 13 220449 8235 42392638
Hyperlactacidaemia 14.20 12.37 3 220459 4513 42396360
Pulmonary oedema 14.20 12.37 192 220270 53080 42347793
Cerebral salt-wasting syndrome 14.19 12.37 7 220455 62 42400811
Neuroborreliosis 14.19 12.37 7 220455 62 42400811
Dermatitis contact 14.15 12.37 3 220459 4500 42396373
Haemoglobin abnormal 14.14 12.37 57 220405 4907 42395966
Urinary bladder rupture 14.13 12.37 8 220454 96 42400777
Herpes simplex test positive 14.12 12.37 11 220451 232 42400641
Complications of transplanted kidney 14.12 12.37 5 220457 5345 42395528
Cold sweat 14.10 12.37 23 220439 11307 42389566
Citrobacter sepsis 14.10 12.37 7 220455 63 42400810
Central nervous system enteroviral infection 14.10 12.37 7 220455 63 42400810
Beta 2 microglobulin increased 14.09 12.37 14 220448 412 42400461
Dysbiosis 14.08 12.37 19 220443 782 42400091
Renal amyloidosis 14.06 12.37 8 220454 97 42400776
Chronic sinusitis 14.00 12.37 44 220418 3348 42397525
Agnosia 13.99 12.37 8 220454 98 42400775
Diffuse large B-cell lymphoma stage II 13.99 12.37 6 220456 37 42400836
Orbital apex syndrome 13.99 12.37 6 220456 37 42400836
Cerebral infarction 13.95 12.37 99 220363 31070 42369803
IgA nephropathy 13.94 12.37 35 220427 2339 42398534
Human rhinovirus test positive 13.93 12.37 12 220450 293 42400580
Autoimmune pancytopenia 13.92 12.37 8 220454 99 42400774
Arterial occlusive disease 13.92 12.37 3 220459 4450 42396423
Gastrointestinal obstruction 13.91 12.37 23 220439 1137 42399736
Urge incontinence 13.90 12.37 16 220446 559 42400314
Respiratory tract infection viral 13.89 12.37 44 220418 3362 42397511
Candida endophthalmitis 13.89 12.37 9 220453 140 42400733
Myelitis 13.87 12.37 22 220440 1050 42399823
Metastases to muscle 13.80 12.37 11 220451 240 42400633
Vascular injury 13.79 12.37 12 220450 297 42400576
Capnocytophaga infection 13.78 12.37 9 220453 142 42400731
Periorbital infection 13.77 12.37 10 220452 189 42400684
Bile duct necrosis 13.73 12.37 7 220455 67 42400806
Jugular vein thrombosis 13.70 12.37 32 220430 2042 42398831
Fracture 13.70 12.37 13 220449 8090 42392783
Restrictive pulmonary disease 13.70 12.37 25 220437 1338 42399535
Ventricular septal defect 13.68 12.37 3 220459 4396 42396477
Dysplasia 13.65 12.37 22 220440 1064 42399809
Quadriplegia 13.64 12.37 33 220429 2154 42398719
Blast cells present 13.64 12.37 15 220447 498 42400375
Erythema multiforme 13.62 12.37 19 220443 9958 42390915
Myositis 13.62 12.37 127 220335 14739 42386134
Follicular mucinosis 13.60 12.37 5 220457 19 42400854
Hepatitis B DNA increased 13.58 12.37 16 220446 573 42400300
Dermatitis acneiform 13.58 12.37 12 220450 7727 42393146
Ankylosing spondylitis 13.55 12.37 10 220452 7046 42393827
Borrelia infection 13.55 12.37 7 220455 69 42400804
B-cell lymphoma stage IV 13.55 12.37 7 220455 69 42400804
Pollakiuria 13.54 12.37 65 220397 22440 42378433
Autologous haematopoietic stem cell transplant 13.52 12.37 8 220454 105 42400768
Peripheral blood stem cell apheresis 13.51 12.37 9 220453 147 42400726
Hypoxia 13.50 12.37 464 219998 69322 42331551
Monoclonal immunoglobulin increased 13.50 12.37 14 220448 434 42400439
Tongue fungal infection 13.48 12.37 6 220456 41 42400832
Multiple-drug resistance 13.44 12.37 74 220388 7248 42393625
Pericarditis 13.42 12.37 117 220345 13327 42387546
Peritoneal lesion 13.41 12.37 9 220453 149 42400724
Cardiac sarcoidosis 13.41 12.37 9 220453 149 42400724
Histiocytosis 13.40 12.37 5 220457 20 42400853
Parosmia 13.40 12.37 12 220450 7679 42393194
Hepatitis 13.39 12.37 207 220255 27093 42373780
Mantle cell lymphoma refractory 13.39 12.37 8 220454 107 42400766
Electrocardiogram ST segment elevation 13.37 12.37 7 220455 5932 42394941
Epstein-Barr virus antigen positive 13.36 12.37 6 220456 42 42400831
Biliary abscess 13.36 12.37 6 220456 42 42400831
Natural killer-cell lymphoblastic lymphoma 13.36 12.37 6 220456 42 42400831
Skin disorder 13.33 12.37 44 220418 16900 42383973
Desmoid tumour 13.32 12.37 8 220454 108 42400765
Pneumothorax spontaneous 13.27 12.37 19 220443 827 42400046
Sinus congestion 13.27 12.37 10 220452 6970 42393903
Pneumonia measles 13.21 12.37 5 220457 21 42400852
Respiratory tract infection bacterial 13.21 12.37 30 220432 1879 42398994
Mediastinal mass 13.21 12.37 11 220451 256 42400617
Gallbladder disorder 13.20 12.37 11 220451 7291 42393582
Joint effusion 13.20 12.37 7 220455 5890 42394983
Torsade de pointes 13.16 12.37 15 220447 8579 42392294
Disease susceptibility 13.13 12.37 7 220455 74 42400799
Quadriparesis 13.13 12.37 34 220428 2316 42398557
Tongue necrosis 13.12 12.37 6 220456 44 42400829
Necrotic lymphadenopathy 13.12 12.37 6 220456 44 42400829
Sinusitis fungal 13.12 12.37 18 220444 753 42400120
Listeriosis 13.08 12.37 25 220437 1386 42399487
Bladder hypertrophy 13.08 12.37 18 220444 755 42400118
Atypical teratoid/rhabdoid tumour of CNS 13.07 12.37 4 220458 7 42400866
Platelet destruction increased 13.07 12.37 4 220458 7 42400866
Post-depletion B-cell recovery 13.07 12.37 4 220458 7 42400866
Tracheal fistula 13.06 12.37 9 220453 156 42400717
Blastic plasmacytoid dendritic cell neoplasia 13.05 12.37 7 220455 75 42400798
Granulocytopenia neonatal 13.03 12.37 5 220457 22 42400851
Campylobacter infection 13.03 12.37 25 220437 1390 42399483
Blood bilirubin decreased 13.01 12.37 16 220446 600 42400273
Toxic erythema of chemotherapy 13.01 12.37 9 220453 157 42400716
Renal cancer 12.98 12.37 14 220448 8210 42392663
Diffuse alveolar damage 12.97 12.37 36 220426 2556 42398317
Fat tissue increased 12.92 12.37 15 220447 529 42400344
POEMS syndrome 12.90 12.37 6 220456 46 42400827
Umbilical hernia 12.90 12.37 6 220456 5441 42395432
Anti-neutrophil cytoplasmic antibody positive vasculitis 12.86 12.37 26 220436 1502 42399371
Adult T-cell lymphoma/leukaemia recurrent 12.85 12.37 5 220457 23 42400850
Immunoglobulins increased 12.83 12.37 10 220452 211 42400662
Haemophilus infection 12.83 12.37 26 220436 1505 42399368
Extrasystoles 12.83 12.37 3 220459 4206 42396667
Retrograde portal vein flow 12.81 12.37 3 220459 0 42400873
Hepatosplenic abscess 12.81 12.37 3 220459 0 42400873
Disseminated large cell lymphoma 12.81 12.37 3 220459 0 42400873
Klippel-Feil syndrome 12.81 12.37 3 220459 0 42400873
Malignant nervous system neoplasm 12.81 12.37 3 220459 0 42400873
Rhinorrhoea 12.81 12.37 104 220358 31690 42369183
Gastritis erosive 12.77 12.37 9 220453 6494 42394379
Carotid artery occlusion 12.76 12.37 3 220459 4191 42396682
Mental disorder 12.73 12.37 49 220413 17980 42382893
Ganglioneuroma 12.73 12.37 4 220458 8 42400865
Tooth fracture 12.72 12.37 3 220459 4181 42396692
Incontinence 12.71 12.37 10 220452 6820 42394053
Bronchospasm 12.71 12.37 30 220432 12855 42388018
Pneumococcal infection 12.70 12.37 15 220447 539 42400334
Skin mass 12.69 12.37 54 220408 4762 42396111
Infusion site pain 12.69 12.37 6 220456 5389 42395484
Hepatitis B e antigen positive 12.68 12.37 6 220456 48 42400825
Urethral obstruction 12.67 12.37 10 220452 215 42400658
Mesangioproliferative glomerulonephritis 12.67 12.37 9 220453 164 42400709
Hepatitis chronic active 12.66 12.37 7 220455 80 42400793
Neutrophil morphology abnormal 12.66 12.37 7 220455 80 42400793
Flagellate dermatitis 12.65 12.37 8 220454 119 42400754
Pulmonary sarcoidosis 12.60 12.37 18 220444 782 42400091
Gastrointestinal protozoal infection 12.59 12.37 7 220455 81 42400792
Pseudomonas aeruginosa meningitis 12.58 12.37 6 220456 49 42400824
Bundle branch block right 12.57 12.37 14 220448 8092 42392781
Tricuspid valve incompetence 12.52 12.37 24 220438 11089 42389784
Urinary bladder toxicity 12.52 12.37 5 220457 25 42400848
Red blood cell schistocytes present 12.51 12.37 12 220450 338 42400535
Hypomagnesaemia 12.50 12.37 91 220371 28397 42372476
Viral load increased 12.48 12.37 39 220423 2958 42397915
Viral skin infection 12.47 12.37 6 220456 50 42400823
Palatal ulcer 12.47 12.37 6 220456 50 42400823
Neutrophil count abnormal 12.42 12.37 37 220425 2734 42398139
Seasonal allergy 12.40 12.37 14 220448 8041 42392832
Sinusitis bacterial 12.39 12.37 15 220447 553 42400320
Retinitis 12.39 12.37 14 220448 479 42400394
Polyarteritis nodosa 12.39 12.37 12 220450 342 42400531
Red blood cell morphology abnormal 12.37 12.37 6 220456 51 42400822

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 13501.75 11.89 10663 427817 306104 109844715
Myelosuppression 5939.17 11.89 4030 434450 90310 110060509
Neutropenia 5426.92 11.89 7035 431445 367585 109783234
Cytokine release syndrome 4756.90 11.89 3142 435338 67164 110083655
Disease progression 4133.93 11.89 4961 433519 239073 109911746
Mucosal inflammation 2453.46 11.89 2428 436052 93713 110057106
Pancytopenia 2417.78 11.89 3532 434948 206081 109944738
Acute myeloid leukaemia 2400.34 11.89 1630 436850 36480 110114339
Bone marrow failure 2322.23 11.89 1887 436593 55961 110094858
Myelodysplastic syndrome 2216.24 11.89 1542 436938 35942 110114877
Off label use 2185.19 11.89 11676 426804 1488509 108662310
White blood cell count decreased 2098.72 11.89 3474 435006 225916 109924903
Cytomegalovirus infection 2080.65 11.89 1726 436754 52718 110098101
Neutrophil count decreased 1851.06 11.89 2339 436141 118602 110032217
Thrombocytopenia 1840.22 11.89 4185 434295 344700 109806119
Haematotoxicity 1799.03 11.89 1092 437388 19990 110130829
Product use in unapproved indication 1744.62 11.89 4782 433698 442595 109708224
Cytomegalovirus infection reactivation 1739.98 11.89 1017 437463 17316 110133503
Acute graft versus host disease 1725.52 11.89 897 437583 11984 110138835
Hypogammaglobulinaemia 1644.32 11.89 1013 437467 19063 110131756
Cystitis haemorrhagic 1643.49 11.89 853 437627 11356 110139463
Second primary malignancy 1516.33 11.89 926 437554 17142 110133677
Venoocclusive liver disease 1510.62 11.89 869 437611 14338 110136481
Diffuse large B-cell lymphoma recurrent 1487.31 11.89 648 437832 5651 110145168
Leukopenia 1426.84 11.89 2303 436177 146488 110004331
Cytopenia 1423.21 11.89 1082 437398 29034 110121785
Pyrexia 1400.18 11.89 7137 431343 891128 109259691
Sepsis 1397.19 11.89 3620 434860 323726 109827093
Immune effector cell-associated neurotoxicity syndrome 1365.92 11.89 806 437674 13976 110136843
Pneumocystis jirovecii pneumonia 1359.10 11.89 1220 437260 41515 110109304
Chronic graft versus host disease 1340.11 11.89 684 437796 8773 110142046
Graft versus host disease 1305.98 11.89 855 437625 17951 110132868
Agranulocytosis 1299.51 11.89 1407 437073 60353 110090466
Septic shock 1294.76 11.89 2276 436204 155252 109995567
Pain 1251.34 11.89 1169 437311 953786 109197033
Progressive multifocal leukoencephalopathy 1217.74 11.89 914 437566 24042 110126777
Arthralgia 1209.08 11.89 805 437675 778827 109371992
Therapy partial responder 1166.63 11.89 1052 437428 36009 110114810
Joint swelling 1152.86 11.89 187 438293 442658 109708161
Acute graft versus host disease in skin 1140.10 11.89 641 437839 10099 110140720
Malignant neoplasm progression 1131.89 11.89 2279 436201 172288 109978531
Fall 1081.54 11.89 521 437959 602961 109547858
Synovitis 1017.54 11.89 13 438467 274079 109876740
Hepatitis B 1015.78 11.89 572 437908 9040 110141779
Posterior reversible encephalopathy syndrome 1008.81 11.89 932 437548 32929 110117890
Febrile bone marrow aplasia 1002.99 11.89 706 437774 16759 110134060
Hepatitis B reactivation 999.01 11.89 520 437960 6964 110143855
Tumour lysis syndrome 986.61 11.89 883 437597 29918 110120901
BK virus infection 981.83 11.89 625 437855 12481 110138338
Neurotoxicity 979.17 11.89 1013 437467 41194 110109625
Haemophagocytic lymphohistiocytosis 972.06 11.89 885 437595 30674 110120145
Cardiotoxicity 968.53 11.89 682 437798 16199 110134620
Neoplasm progression 941.57 11.89 1220 437260 63375 110087444
Multiple organ dysfunction syndrome 888.73 11.89 1900 436580 149810 110001009
Disease recurrence 885.93 11.89 1148 437332 59636 110091183
Neuropathy peripheral 875.97 11.89 2089 436391 177188 109973631
Pruritus 874.74 11.89 620 437860 580940 109569879
Arthropathy 867.68 11.89 73 438407 287449 109863370
Platelet count decreased 857.35 11.89 2424 436056 228019 109922800
Drug hypersensitivity 853.70 11.89 366 438114 453724 109697095
Nasopharyngitis 851.78 11.89 253 438227 394108 109756711
Peripheral swelling 847.91 11.89 273 438207 403761 109747058
Completed suicide 845.80 11.89 25 438455 242356 109908463
Abdominal discomfort 842.84 11.89 257 438223 393601 109757218
Neutropenic sepsis 836.95 11.89 805 437675 29941 110120878
Product dose omission issue 823.55 11.89 142 438338 321640 109829179
Swelling 823.16 11.89 191 438289 350850 109799969
Pemphigus 815.85 11.89 6 438474 214564 109936255
Rheumatoid arthritis 815.15 11.89 111 438369 299502 109851317
Respiratory failure 804.84 11.89 2269 436211 213063 109937756
Epstein-Barr virus infection 789.25 11.89 629 437851 18109 110132710
Glossodynia 785.39 11.89 20 438460 221984 109928835
Bronchopulmonary aspergillosis 771.87 11.89 760 437720 29103 110121716
Wound 764.60 11.89 40 438440 234397 109916422
Weight increased 760.88 11.89 356 438124 419288 109731531
Systemic lupus erythematosus 739.53 11.89 75 438405 254263 109896556
Graft versus host disease in skin 736.29 11.89 440 438040 7814 110143005
Psoriatic arthropathy 736.19 11.89 8 438472 196753 109954066
Venoocclusive disease 726.02 11.89 398 438082 5952 110144867
Aspergillus infection 711.09 11.89 678 437802 24938 110125881
Thrombotic microangiopathy 707.63 11.89 717 437763 28432 110122387
Dizziness 705.71 11.89 1048 437432 697145 109453674
Musculoskeletal stiffness 687 11.89 137 438343 279685 109871134
Rash 685.44 11.89 1391 437089 819573 109331246
Lymphopenia 683.50 11.89 820 437660 39350 110111469
Anaemia 670.92 11.89 4080 434400 543006 109607813
Adenovirus infection 670.08 11.89 461 438019 10533 110140286
Fatigue 667.84 11.89 2527 435953 1213431 108937388
Diffuse large B-cell lymphoma 659.63 11.89 529 437951 15369 110135450
Headache 658.85 11.89 1590 436890 880787 109270032
Duodenal ulcer perforation 644.25 11.89 12 438468 177688 109973131
Anxiety 643.77 11.89 281 438199 344797 109806022
Fibromyalgia 639.15 11.89 7 438473 170902 109979917
Malaise 630.85 11.89 1059 437421 670760 109480059
Interstitial lung disease 630.79 11.89 1577 436903 137757 110013062
Cytomegalovirus viraemia 616.39 11.89 533 437947 17231 110133588
Therapeutic product effect decreased 611.60 11.89 114 438366 244202 109906617
Urticaria 610.23 11.89 250 438230 318607 109832212
Helicobacter infection 609.29 11.89 26 438454 181851 109968968
Contraindicated product administered 598.13 11.89 127 438353 248140 109902679
Irritable bowel syndrome 595.68 11.89 11 438469 164204 109986615
Mobility decreased 585.37 11.89 115 438365 237307 109913512
Pain in extremity 583.09 11.89 643 437837 486475 109664344
Graft versus host disease in gastrointestinal tract 582.15 11.89 391 438089 8577 110142242
Contusion 581.77 11.89 110 438370 233251 109917568
Wheezing 580.30 11.89 148 438332 255082 109895737
Drug abuse 569.98 11.89 33 438447 177378 109973441
Blood cholesterol increased 562.65 11.89 45 438435 184740 109966079
Post transplant lymphoproliferative disorder 557.06 11.89 476 438004 15137 110135682
Injury 554.48 11.89 38 438442 177227 109973592
Overdose 546.28 11.89 128 438352 233666 109917153
Hypersensitivity 535.22 11.89 488 437992 403510 109747309
Cytomegalovirus chorioretinitis 534.10 11.89 340 438140 6788 110144031
Osteoarthritis 533.03 11.89 53 438427 182570 109968249
Muscle spasms 532.35 11.89 218 438262 277939 109872880
Acute lymphocytic leukaemia recurrent 525.33 11.89 312 438168 5475 110145344
Insomnia 523.98 11.89 398 438082 360192 109790627
Injection site pain 508.06 11.89 56 438424 177866 109972953
Depression 501.10 11.89 320 438160 317015 109833804
Folliculitis 496.32 11.89 46 438434 167607 109983212
Drug ineffective for unapproved indication 493.01 11.89 1190 437290 101648 110049171
Type 2 diabetes mellitus 490.66 11.89 62 438418 177170 109973649
Cardiomyopathy 486.57 11.89 632 437848 32893 110117926
Ejection fraction decreased 486.48 11.89 700 437780 40180 110110639
Asthma 485.74 11.89 192 438288 250099 109900720
Impaired healing 481.30 11.89 97 438383 196620 109954199
Human herpesvirus 6 infection 478.46 11.89 308 438172 6273 110144546
Intentional overdose 476.05 11.89 10 438470 132491 110018328
Hepatic enzyme increased 474.15 11.89 348 438132 320544 109830275
Sleep disorder 469.55 11.89 106 438374 198538 109952281
Blister 469.01 11.89 158 438322 227218 109923601
Blood lactate dehydrogenase increased 460.08 11.89 712 437768 43622 110107197
Viral haemorrhagic cystitis 458.90 11.89 238 438242 3161 110147658
Bursitis 440.41 11.89 17 438463 129901 110020918
Blood pressure increased 436.84 11.89 240 438240 258133 109892686
Bacteraemia 431.83 11.89 675 437805 41715 110109104
Drug interaction 430.01 11.89 832 437648 499351 109651468
Migraine 425.47 11.89 82 438398 171570 109979249
Lymphadenopathy 419.97 11.89 839 437641 62996 110087823
Lymphocyte count decreased 410.22 11.89 780 437700 56463 110094356
Psoriasis 407.54 11.89 41 438439 139952 110010867
Premature menopause 407.38 11.89 154 438326 888 110149931
Inappropriate schedule of product administration 405.42 11.89 150 438330 203487 109947332
Dry mouth 403.64 11.89 144 438336 199804 109951015
Cardiac failure 400.49 11.89 1639 436841 185987 109964832
Polyneuropathy 398.37 11.89 560 437920 31452 110119367
Infusion related reaction 393.39 11.89 563 437917 380599 109770220
Joint range of motion decreased 390.27 11.89 23 438457 121809 110029010
C-reactive protein abnormal 388.14 11.89 34 438446 129661 110021158
Aplasia 381.02 11.89 287 438193 7586 110143233
Feeling abnormal 378.93 11.89 122 438358 180589 109970230
Abdominal pain upper 371.90 11.89 504 437976 348607 109802212
Pericarditis 368.24 11.89 205 438275 218909 109931910
Dyspnoea 367.76 11.89 2726 435754 1104146 109046673
Lip dry 357.76 11.89 8 438472 100075 110050744
Loss of personal independence in daily activities 352.62 11.89 81 438399 149939 110000880
Musculoskeletal pain 352.42 11.89 142 438338 182881 109967938
Discomfort 352.07 11.89 207 438273 214500 109936319
Drug ineffective 351.15 11.89 8183 430297 1512357 108638462
Acute graft versus host disease in intestine 349.67 11.89 239 438241 5400 110145419
Sinusitis 348.81 11.89 397 438083 296291 109854528
Somnolence 347.55 11.89 400 438080 297049 109853770
Staphylococcal bacteraemia 338.34 11.89 373 438107 16315 110134504
Klebsiella infection 336.32 11.89 406 438074 19603 110131216
Herpes simplex 334.68 11.89 361 438119 15403 110135416
Arthritis 334.33 11.89 123 438357 167463 109983356
Clostridium difficile colitis 332.98 11.89 612 437868 43166 110107653
Confusional state 332.97 11.89 865 437615 467815 109683004
Diffuse large B-cell lymphoma refractory 330.27 11.89 173 438307 2348 110148471
JC virus infection 327.53 11.89 224 438256 5066 110145753
Plasma cell myeloma recurrent 326.00 11.89 250 438230 6792 110144027
Neutropenic colitis 325.32 11.89 264 438216 7801 110143018
Intentional product misuse 324.09 11.89 66 438414 132838 110017981
Gait disturbance 323.00 11.89 376 438104 277832 109872987
Enterococcal infection 322.51 11.89 401 438079 19965 110130854
Road traffic accident 321.80 11.89 28 438452 107370 110043449
Stem cell transplant 321.37 11.89 207 438273 4220 110146599
Chronic graft versus host disease in skin 310.07 11.89 168 438312 2451 110148368
Secondary immunodeficiency 306.21 11.89 205 438275 4471 110146348
Gait inability 304.30 11.89 82 438398 136294 110014525
Neoplasm recurrence 303.87 11.89 213 438267 5019 110145800
Hospitalisation 302.64 11.89 94 438386 142399 110008420
B-cell lymphoma recurrent 299.25 11.89 127 438353 1031 110149788
Granulocyte count decreased 296.36 11.89 189 438291 3785 110147034
Prescribed overdose 295 11.89 12 438468 87569 110063250
Cystitis viral 294.83 11.89 135 438345 1338 110149481
Dyspepsia 291.27 11.89 200 438280 190765 109960054
Hepatic function abnormal 290.32 11.89 896 437584 88399 110062420
Epstein-Barr virus associated lymphoproliferative disorder 289.44 11.89 200 438280 4602 110146217
Suicide attempt 288.99 11.89 35 438445 103359 110047460
Candida infection 286.30 11.89 606 437874 47403 110103416
Ovarian failure 285.74 11.89 117 438363 859 110149960
Stress 284.03 11.89 40 438440 105308 110045511
Pneumonia fungal 282.36 11.89 320 438160 14434 110136385
Pseudomonas infection 281.56 11.89 442 438038 27411 110123408
Drug resistance 279.43 11.89 661 437819 55713 110095106
Acute lymphocytic leukaemia 274.21 11.89 208 438272 5557 110145262
Grip strength decreased 273.40 11.89 10 438470 80164 110070655
Bacterial infection 272.10 11.89 579 437901 45457 110105362
Metastases to bone 270.05 11.89 463 438017 30909 110119910
Drug intolerance 269.38 11.89 776 437704 405736 109745083
Pleural effusion 269.14 11.89 1404 437076 176305 109974514
Bacterial sepsis 266.89 11.89 264 438216 10162 110140657
Sciatica 266.49 11.89 28 438452 92371 110058448
Peripheral venous disease 266.03 11.89 17 438463 84100 110066719
Systemic mycosis 265.59 11.89 174 438306 3655 110147164
Gastrooesophageal reflux disease 263.34 11.89 197 438283 179779 109971040
Encephalitis cytomegalovirus 261.48 11.89 135 438345 1775 110149044
Engraftment syndrome 260.03 11.89 135 438345 1797 110149022
Pneumonia 259.68 11.89 4897 433583 871817 109279002
Congestive cardiomyopathy 259.63 11.89 301 438179 13918 110136901
Weight decreased 258.70 11.89 968 437512 467089 109683730
Acute promyelocytic leukaemia 256.66 11.89 133 438347 1763 110149056
Memory impairment 255.71 11.89 242 438238 196702 109954117
Injection site erythema 255.68 11.89 35 438445 94141 110056678
Lower limb fracture 254.88 11.89 10 438470 75338 110075481
Epstein-Barr viraemia 254.02 11.89 165 438315 3414 110147405
Product quality issue 252.50 11.89 13 438467 77286 110073533
Hepatic failure 252.21 11.89 720 437760 68019 110082800
Alopecia 249.99 11.89 685 437795 364068 109786751
Hypoaesthesia 245.89 11.89 551 437929 313672 109837147
Incorrect dose administered 245.47 11.89 55 438425 103586 110047233
Cardiac dysfunction 245.32 11.89 201 438279 6022 110144797
Left ventricular dysfunction 244.71 11.89 378 438102 23115 110127704
Mucormycosis 244.46 11.89 254 438226 10374 110140445
Injection site reaction 244.44 11.89 32 438448 89038 110061781
Staphylococcal sepsis 242.35 11.89 322 438158 17132 110133687
COVID-19 241.47 11.89 1732 436748 243328 109907491
Maternal exposure during pregnancy 240.29 11.89 400 438080 254483 109896336
Frequent bowel movements 239.71 11.89 10 438470 71380 110079439
Osteonecrosis 237.09 11.89 456 438024 33285 110117534
Nephropathy toxic 235.82 11.89 405 438075 27073 110123746
Varicella zoster virus infection 233.01 11.89 197 438283 6171 110144648
Wound infection 232.92 11.89 49 438431 96416 110054403
Pneumonia cytomegaloviral 231.88 11.89 204 438276 6750 110144069
Hypercholesterolaemia 230.19 11.89 41 438439 90796 110060023
Epstein-Barr virus infection reactivation 229.61 11.89 163 438317 3921 110146898
Cytogenetic abnormality 227.59 11.89 106 438374 1096 110149723
Lymphoma 222.04 11.89 333 438147 19838 110130981
Pneumonitis 220.67 11.89 737 437743 75794 110075025
Fungal infection 219.29 11.89 565 437915 50241 110100578
Medication error 217.56 11.89 73 438407 105293 110045526
Acute graft versus host disease in liver 216.26 11.89 128 438352 2231 110148588
Lower respiratory tract infection 215.11 11.89 397 438083 242709 109908110
Heart rate decreased 214.89 11.89 35 438445 82721 110068098
Staphylococcal infection 214.64 11.89 688 437792 69256 110081563
Rhinovirus infection 214.32 11.89 249 438231 11540 110139279
Cytokine increased 212.71 11.89 67 438413 197 110150622
Leukoencephalopathy 211.94 11.89 220 438260 8975 110141844
Acquired gene mutation 207.91 11.89 132 438348 2622 110148197
Transplant failure 207.57 11.89 175 438305 5460 110145359
Amnesia 207.46 11.89 79 438401 105329 110045490
Pseudomonal sepsis 205.93 11.89 215 438265 8831 110141988
Systemic candida 205.78 11.89 225 438255 9749 110141070
Myocardial infarction 205.72 11.89 276 438204 191807 109959012
Bronchitis 204.96 11.89 192 438288 156840 109993979
Metastases to liver 204.46 11.89 441 438039 34945 110115874
Sedation 203.85 11.89 20 438460 69663 110081156
Enterococcal bacteraemia 203.50 11.89 157 438323 4304 110146515
Hypertension 203.19 11.89 1188 437292 508896 109641923
Rhabdomyolysis 203.16 11.89 112 438368 120289 110030530
Chest pain 202.31 11.89 787 437693 375588 109775231
Neck pain 201.38 11.89 119 438361 123011 110027808
Organising pneumonia 201.21 11.89 265 438215 13978 110136841
Injection site swelling 199.92 11.89 11 438469 61779 110089040
Suicidal ideation 199.40 11.89 62 438418 93875 110056944
Peripheral sensory neuropathy 198.98 11.89 286 438194 16394 110134425
Pneumatosis intestinalis 196.47 11.89 204 438276 8325 110142494
Central nervous system lymphoma 195.85 11.89 132 438348 2912 110147907
Aplastic anaemia 195.25 11.89 348 438132 23960 110126859
Human polyomavirus infection 195.18 11.89 109 438371 1693 110149126
Hepatotoxicity 194.87 11.89 624 437856 62776 110088043
Leukaemia recurrent 192.47 11.89 132 438348 2999 110147820
Obesity 191.89 11.89 105 438375 113246 110037573
Chronic lymphocytic leukaemia recurrent 190.87 11.89 90 438390 959 110149860
Parainfluenzae virus infection 190.51 11.89 183 438297 6791 110144028
Metastases to lymph nodes 190.04 11.89 265 438215 14767 110136052
Mantle cell lymphoma recurrent 189.68 11.89 89 438391 937 110149882
Escherichia sepsis 188.48 11.89 218 438262 10054 110140765
Inflammation 187.97 11.89 297 438183 192941 109957878
Colitis ulcerative 187.39 11.89 39 438441 77324 110073495
Hypoglycaemia 187.36 11.89 114 438366 115990 110034829
Joint stiffness 187.33 11.89 23 438457 67220 110083599
Infection reactivation 186.98 11.89 144 438336 3937 110146882
Adverse event 186.82 11.89 99 438381 108710 110042109
Night sweats 186.71 11.89 154 438326 133829 110016990
B-cell type acute leukaemia 184.79 11.89 98 438382 1366 110149453
Acute respiratory distress syndrome 184.36 11.89 546 437934 52652 110098167
Hyperhidrosis 183.96 11.89 286 438194 187012 109963807
Adverse drug reaction 182.78 11.89 95 438385 105464 110045355
Disseminated intravascular coagulation 182.19 11.89 463 438017 40823 110109996
Myelopathy 180.79 11.89 161 438319 5415 110145404
Prescribed underdose 179.84 11.89 23 438457 65151 110085668
Angioedema 179.11 11.89 83 438397 98417 110052402
Injection site pruritus 176.14 11.89 6 438474 51252 110099567
Therapy non-responder 175.80 11.89 1147 437333 156160 109994659
Plasmacytoma 174.72 11.89 154 438326 5108 110145711
Live birth 174.68 11.89 32 438448 69452 110081367
Breast cancer recurrent 174.67 11.89 135 438345 3711 110147108
Chronic obstructive pulmonary disease 173.62 11.89 109 438371 109049 110041770
Injection site bruising 172.72 11.89 7 438473 51256 110099563
Metastases to lung 171.08 11.89 319 438161 22744 110128075
Acute myeloid leukaemia recurrent 169.84 11.89 150 438330 4989 110145830
Viraemia 169.10 11.89 136 438344 3966 110146853
Illness 166.07 11.89 59 438421 82112 110068707
Foot deformity 165.46 11.89 6 438474 48474 110102345
COVID-19 pneumonia 165.42 11.89 418 438062 36725 110114094
Dry skin 165.11 11.89 112 438368 107541 110043278
Escherichia bacteraemia 163.94 11.89 202 438278 9962 110140857
Escherichia infection 163.82 11.89 319 438161 23497 110127322
Cytomegalovirus test positive 163.35 11.89 169 438311 6867 110143952
Blood pressure systolic increased 161.99 11.89 63 438417 82928 110067891
Thymus hypoplasia 161.13 11.89 94 438386 1593 110149226
Gastrointestinal toxicity 159.93 11.89 209 438271 10939 110139880
Blepharospasm 159.78 11.89 16 438464 54835 110095984
Lymphoid tissue hypoplasia 159.62 11.89 93 438387 1572 110149247
Intestinal perforation 159.52 11.89 293 438187 20651 110130168
Loss of consciousness 159.47 11.89 337 438143 195969 109954850
Exostosis 159.27 11.89 5 438475 45951 110104868
International normalised ratio increased 157.96 11.89 73 438407 86699 110064120
Bone marrow disorder 157.31 11.89 132 438348 4091 110146728
Hepatitis E 157.13 11.89 135 438345 4324 110146495
Gene mutation 157.12 11.89 121 438359 3308 110147511
Blood glucose increased 155.92 11.89 177 438303 132319 110018500
Swollen tongue 155.67 11.89 26 438454 60336 110090483
Metastases to central nervous system 154.98 11.89 304 438176 22513 110128306
Ill-defined disorder 154.52 11.89 239 438241 156614 109994205
Coeliac disease 152.24 11.89 4 438476 43183 110107636
Sweat gland tumour 151.82 11.89 64 438416 510 110150309
Pneumomediastinum 150.70 11.89 139 438341 4897 110145922
Enterobacter infection 150.33 11.89 148 438332 5663 110145156
Sleep disorder due to a general medical condition 149.73 11.89 16 438464 52096 110098723
Heart rate increased 148.65 11.89 212 438268 143622 110007197
Strongyloidiasis 148.00 11.89 137 438343 4849 110145970
Capillary leak syndrome 147.90 11.89 136 438344 4772 110146047
Dislocation of vertebra 147.20 11.89 6 438474 43715 110107104
Device related infection 145.98 11.89 415 438065 39104 110111715
Nasal congestion 145.77 11.89 106 438374 98176 110052643
Breast cancer metastatic 145.68 11.89 200 438280 10981 110139838
Toxoplasmosis 145.59 11.89 113 438367 3126 110147693
Hypoalbuminaemia 144.94 11.89 341 438139 28633 110122186
Klebsiella sepsis 144.85 11.89 125 438355 4028 110146791
Bradycardia 144.72 11.89 246 438234 155271 109995548
Drug effective for unapproved indication 143.44 11.89 225 438255 13942 110136877
Blood pressure fluctuation 142.45 11.89 59 438421 74765 110076054
Red blood cell sedimentation rate increased 142.34 11.89 66 438414 78236 110072583
Onychomadesis 142.12 11.89 10 438470 45653 110105166
Brain abscess 141.82 11.89 154 438326 6620 110144199
Balance disorder 141.24 11.89 152 438328 116408 110034411
Eczema 140.90 11.89 55 438425 72238 110078581
Hallucination 140.80 11.89 117 438363 101315 110049504
Computerised tomogram thorax abnormal 139.96 11.89 104 438376 2691 110148128
Refractory anaemia with an excess of blasts 139.91 11.89 68 438412 779 110150040
Toxicity to various agents 139.78 11.89 1225 437255 479330 109671489
Exposure during pregnancy 139.71 11.89 283 438197 167141 109983678
Skin toxicity 139.04 11.89 201 438279 11582 110139237
Lymphoproliferative disorder 138.88 11.89 157 438323 7061 110143758
Fusarium infection 138.51 11.89 103 438377 2668 110148151
Blood stem cell transplant failure 138.06 11.89 64 438416 654 110150165
Autoimmune disorder 137.59 11.89 44 438436 65439 110085380
Nocardiosis 137.56 11.89 159 438321 7327 110143492
Serotonin syndrome 136.87 11.89 33 438447 59120 110091699
Accidental overdose 136.66 11.89 21 438459 51813 110099006
Pulmonary haemorrhage 136.57 11.89 239 438241 16217 110134602
Coronary artery disease 135.72 11.89 57 438423 71633 110079186
Back pain 135.18 11.89 888 437592 370108 109780711
Rectal haemorrhage 133.63 11.89 167 438313 119666 110031153
Graft versus host disease in liver 133.11 11.89 96 438384 2369 110148450
Human herpesvirus 6 encephalitis 133.04 11.89 71 438409 1003 110149816
Feeling hot 132.87 11.89 100 438380 91006 110059813
Metastasis 132.86 11.89 164 438316 8103 110142716
Product prescribing error 132.62 11.89 22 438458 51309 110099510
Pericardial effusion 132.53 11.89 513 437967 56704 110094115
Plasma cell myeloma refractory 131.69 11.89 88 438392 1913 110148906
Granulocytopenia 131.60 11.89 204 438276 12511 110138308
Respiratory syncytial virus infection 131.60 11.89 219 438261 14265 110136554
Hypoxia 131.32 11.89 922 437558 128593 110022226
Lung infiltration 131.06 11.89 297 438183 24331 110126488
Bone pain 131.03 11.89 559 437921 64574 110086245
Multiple sclerosis relapse 130.99 11.89 21 438459 50219 110100600
Condition aggravated 130.69 11.89 2088 436392 732748 109418071
Joint injury 129.76 11.89 7 438473 39987 110110832
Engraft failure 129.52 11.89 64 438416 762 110150057
Oedema peripheral 128.33 11.89 770 437710 327890 109822929
Post transplant distal limb syndrome 128.32 11.89 65 438415 819 110150000
Cerebrovascular accident 128.20 11.89 335 438145 180949 109969870
Encephalitis 127.95 11.89 251 438229 18588 110132231
Acute myelomonocytic leukaemia 125.93 11.89 52 438428 391 110150428
Rash pruritic 125.50 11.89 122 438358 97947 110052872
Alpha haemolytic streptococcal infection 125.03 11.89 108 438372 3485 110147334
Encephalopathy 124.43 11.89 643 437837 80412 110070407
Human bocavirus infection 124.27 11.89 69 438411 1059 110149760
Palpitations 122.97 11.89 281 438199 158931 109991888
Clostridium difficile infection 122.88 11.89 470 438010 51659 110099160
Polyomavirus viraemia 122.06 11.89 105 438375 3369 110147450
Cytomegalovirus colitis 121.49 11.89 145 438335 6916 110143903
Hip arthroplasty 119.96 11.89 36 438444 55777 110095042
Delirium 119.83 11.89 220 438260 134805 110016014
Haematochezia 119.64 11.89 170 438310 115354 110035465
Incorrect route of product administration 119.57 11.89 52 438428 64009 110086810
Bone erosion 119.52 11.89 20 438460 46351 110104468
Blood follicle stimulating hormone increased 119.40 11.89 49 438431 362 110150457
Recurrent cancer 119.33 11.89 103 438377 3320 110147499
Infection 118.30 11.89 2056 436424 360144 109790675
Pregnancy 117.16 11.89 29 438451 51038 110099781
Nightmare 116.76 11.89 10 438470 38853 110111966
Graft versus host disease in lung 116.25 11.89 69 438411 1209 110149610
Hyperpyrexia 113.78 11.89 150 438330 7919 110142900
Pneumocystis jirovecii infection 113.71 11.89 112 438368 4288 110146531
Lupus-like syndrome 113.51 11.89 14 438466 40778 110110041
Colony stimulating factor therapy 113.50 11.89 54 438426 588 110150231
Injection site haemorrhage 113.02 11.89 4 438476 33024 110117795
Therapy interrupted 112.93 11.89 29 438451 49793 110101026
Nephrolithiasis 112.55 11.89 61 438419 66151 110084668
Lactic acidosis 112.48 11.89 121 438359 92690 110058129
Underdose 111.81 11.89 56 438424 63498 110087321
Fungaemia 111.39 11.89 129 438351 5957 110144862
Aggression 110.61 11.89 48 438432 59162 110091657
Refractory cytopenia with multilineage dysplasia 110.58 11.89 41 438439 222 110150597
Cerebral toxoplasmosis 110.46 11.89 95 438385 3047 110147772
Myeloid leukaemia 109.78 11.89 59 438421 846 110149973
Ear infection 109.27 11.89 56 438424 62676 110088143
Chronic myeloid leukaemia 109.00 11.89 108 438372 4165 110146654
Chronic graft versus host disease in liver 108.75 11.89 59 438421 863 110149956
Drug withdrawal syndrome 108.53 11.89 12 438468 38042 110112777
Pulmonary alveolar haemorrhage 108.34 11.89 244 438236 19906 110130913
Visual impairment 108.13 11.89 232 438248 134196 110016623
Peripheral T-cell lymphoma unspecified 107.84 11.89 58 438422 833 110149986
Onychomycosis 107.76 11.89 13 438467 38518 110112301
Venous thrombosis 107.61 11.89 150 438330 8355 110142464
Liver function test increased 106.69 11.89 116 438364 88432 110062387
Fluid retention 106.64 11.89 130 438350 94177 110056642
C-reactive protein 106.20 11.89 3 438477 30328 110120491
Laryngitis 105.60 11.89 20 438460 42391 110108428
Nodular regenerative hyperplasia 105.59 11.89 71 438409 1560 110149259
Eye pruritus 105.52 11.89 6 438474 32769 110118050
Splenomegaly 105.25 11.89 272 438208 24226 110126593
Meningitis cryptococcal 104.51 11.89 111 438369 4651 110146168
Mycobacterium chelonae infection 104.50 11.89 91 438389 2969 110147850
Erythema 104.42 11.89 701 437779 290746 109860073
Lymphoma transformation 104.33 11.89 50 438430 554 110150265
Emotional distress 103.80 11.89 25 438455 44822 110105997
Palmar-plantar erythrodysaesthesia syndrome 103.45 11.89 378 438102 40647 110110172
Drug dependence 102.65 11.89 35 438445 49985 110100834
Blood fibrinogen decreased 102.52 11.89 85 438395 2590 110148229
Immune-mediated adrenal insuficiency 102.29 11.89 72 438408 1708 110149111
Procedural pain 101.97 11.89 11 438469 35554 110115265
Nervous system disorder 101.86 11.89 317 438163 31404 110119415
Autoimmune haemolytic anaemia 100.35 11.89 163 438317 10404 110140415
Scedosporium infection 100.28 11.89 81 438399 2377 110148442
Burning sensation 99.61 11.89 77 438403 69135 110081684
Glioblastoma multiforme 99.20 11.89 66 438414 1424 110149395
Renal failure 98.44 11.89 1350 437130 225224 109925595
Encephalitis viral 97.84 11.89 87 438393 2920 110147899
Plasma cell myeloma 97.81 11.89 501 437979 62435 110088384
Disseminated aspergillosis 97.54 11.89 80 438400 2400 110148419
End stage renal disease 97.02 11.89 243 438237 21230 110129589
Cystitis bacterial 96.95 11.89 61 438419 1192 110149627
Chemotherapy 96.74 11.89 75 438405 2071 110148748
Colitis 96.54 11.89 716 437764 101607 110049212
Oxygen saturation decreased 96.45 11.89 310 438170 156672 109994147
Pneumonia bacterial 96.24 11.89 275 438205 25986 110124833
Lupus nephritis 96.20 11.89 105 438375 4540 110146279
Pneumonia klebsiella 96.17 11.89 125 438355 6507 110144312
Gastrosplenic fistula 96.13 11.89 32 438448 118 110150701
Minimal residual disease 96.07 11.89 55 438425 898 110149921
Paraesthesia 95.15 11.89 673 437807 275848 109874971
B-cell aplasia 94.53 11.89 41 438439 353 110150466
Hyperbilirubinaemia 94.35 11.89 302 438178 30369 110120450
Klebsiella bacteraemia 93.84 11.89 106 438374 4763 110146056
Tremor 93.78 11.89 447 438033 201785 109949034
Primary amyloidosis 93.15 11.89 38 438442 276 110150543
Ovarian atrophy 93.02 11.89 28 438452 67 110150752
Myelitis 92.89 11.89 87 438393 3126 110147693
Polyomavirus-associated nephropathy 92.57 11.89 137 438343 8064 110142755
Human herpesvirus 6 infection reactivation 92.50 11.89 57 438423 1072 110149747
Labelled drug-drug interaction medication error 92.41 11.89 6 438474 29296 110121523
Generalised oedema 92.35 11.89 300 438180 30404 110120415
Streptococcal bacteraemia 92.30 11.89 103 438377 4566 110146253
Abdominal distension 92.16 11.89 369 438111 174734 109976085
Adenovirus reactivation 91.89 11.89 49 438431 691 110150128
Lip swelling 91.63 11.89 43 438437 50624 110100195
Acute monocytic leukaemia 91.63 11.89 46 438434 568 110150251
Complications of bone marrow transplant 91.50 11.89 47 438433 611 110150208
Leukaemia cutis 91.43 11.89 35 438445 210 110150609
Primary hypogonadism 91.29 11.89 35 438445 211 110150608
Oesophageal candidiasis 91.19 11.89 164 438316 11370 110139449
Restlessness 91.09 11.89 55 438425 56204 110094615
Diarrhoea 91.05 11.89 3646 434834 1135859 109014960
Hyperkalaemia 90.71 11.89 258 438222 135538 110015281
Malignant transformation 90.70 11.89 63 438417 1462 110149357
Diffuse alveolar damage 90.00 11.89 95 438385 3952 110146867
Norovirus test positive 89.88 11.89 53 438427 917 110149902
Plasma cell leukaemia 89.86 11.89 71 438409 2017 110148802
Joint dislocation 89.79 11.89 14 438466 34176 110116643
Renal tubular injury 89.55 11.89 84 438396 3024 110147795
Myalgia 89.42 11.89 516 437964 221865 109928954
Biopsy lung abnormal 89.26 11.89 31 438449 134 110150685
Withdrawal syndrome 89.22 11.89 10 438470 31370 110119449
Candida sepsis 89.13 11.89 82 438398 2879 110147940
Oedema 88.90 11.89 479 438001 209497 109941322
B-lymphocyte count decreased 88.70 11.89 70 438410 1985 110148834
5q minus syndrome 88.65 11.89 36 438444 258 110150561
Electrocardiogram QT prolonged 88.50 11.89 187 438293 108773 110042046
Nervousness 88.37 11.89 19 438461 36832 110113987
Breast cancer stage II 88.16 11.89 5 438475 27370 110123449
Bone marrow transplant rejection 88.08 11.89 37 438443 292 110150527
Osteosarcoma 88.01 11.89 40 438440 389 110150430
Anti-Muellerian hormone level decreased 87.75 11.89 28 438452 87 110150732
Squamous cell carcinoma of skin 87.72 11.89 204 438276 16999 110133820
Pseudomonal bacteraemia 87.39 11.89 97 438383 4274 110146545
Muscle spasticity 87.19 11.89 18 438462 35897 110114922
Limb injury 87.06 11.89 21 438459 37615 110113204
Pseudocirrhosis 87.02 11.89 51 438429 872 110149947
Ascites 86.75 11.89 648 437832 92160 110058659
Glioma 86.19 11.89 50 438430 838 110149981
Flatulence 85.82 11.89 50 438430 52099 110098720
Obliterative bronchiolitis 85.67 11.89 89 438391 3634 110147185
Retinitis viral 85.43 11.89 40 438440 419 110150400
Agitation 85.30 11.89 202 438278 112849 110037970
Unevaluable event 85.10 11.89 66 438414 59161 110091658
Pulmonary toxicity 84.60 11.89 205 438275 17541 110133278
Device related thrombosis 83.71 11.89 85 438395 3377 110147442
Aortitis 83.47 11.89 67 438413 1948 110148871
Chronic myelomonocytic leukaemia 82.88 11.89 52 438428 1011 110149808
Humoral immune defect 82.79 11.89 46 438434 707 110150112
Neutrophil count abnormal 82.78 11.89 102 438378 5030 110145789
Guillain-Barre syndrome 82.69 11.89 151 438329 10593 110140226
Respiratory tract congestion 82.50 11.89 12 438468 30845 110119974
Respiratory distress 82.34 11.89 511 437969 68363 110082456
Microsporidia infection 82.21 11.89 58 438422 1381 110149438
Skin laceration 81.77 11.89 17 438463 33736 110117083
White blood cell count abnormal 81.73 11.89 118 438362 6791 110144028
Sopor 81.45 11.89 22 438458 36524 110114295
Herpes zoster 81.42 11.89 720 437760 107659 110043160
Blood creatine phosphokinase increased 81.30 11.89 102 438378 72975 110077844
Sinus congestion 81.07 11.89 12 438468 30447 110120372
Adenoviral haemorrhagic cystitis 80.72 11.89 44 438436 650 110150169
Ventricular hypokinesia 80.55 11.89 153 438327 11061 110139758
Peripheral motor neuropathy 80.54 11.89 90 438390 3996 110146823
Vision blurred 80.51 11.89 253 438227 128769 110022050
Immunosuppression 80.27 11.89 201 438279 17558 110133261
Swelling face 79.63 11.89 153 438327 92168 110058651
Wrong technique in product usage process 79.57 11.89 140 438340 87208 110063611
Throat irritation 79.09 11.89 58 438422 53494 110097325
Abdominal pain 79.05 11.89 1495 436985 511494 109639325
Epstein-Barr virus associated lymphoma 78.87 11.89 60 438420 1610 110149209
Subclavian vein thrombosis 78.66 11.89 75 438405 2757 110148062
Head injury 78.58 11.89 36 438444 42981 110107838
Idiopathic pneumonia syndrome 78.37 11.89 47 438433 840 110149979
Product substitution issue 78.19 11.89 3 438477 23058 110127761
Adverse reaction 77.99 11.89 12 438468 29582 110121237
Sneezing 77.71 11.89 16 438464 31968 110118851
Neutropenic infection 77.24 11.89 79 438401 3166 110147653
Dyskinesia 76.92 11.89 55 438425 51391 110099428
Traumatic lung injury 76.86 11.89 71 438409 2506 110148313
Osteolysis 76.84 11.89 102 438378 5421 110145398
Vertigo 76.66 11.89 142 438338 86728 110064091
Metastases to meninges 76.47 11.89 98 438382 5030 110145789
Herpes virus infection 76.33 11.89 129 438351 8509 110142310
Drug reaction with eosinophilia and systemic symptoms 76.23 11.89 130 438350 81965 110068854
B precursor type acute leukaemia 76.14 11.89 38 438442 463 110150356
Radiotherapy 75.93 11.89 56 438424 1432 110149387
Serum ferritin increased 75.84 11.89 154 438326 11693 110139126
Ileus paralytic 75.65 11.89 153 438327 11584 110139235
Blood pressure diastolic decreased 75.58 11.89 24 438456 35861 110114958
Metastases to bone marrow 75.05 11.89 48 438432 966 110149853
Acne 75.04 11.89 20 438460 33500 110117319
Injection site mass 74.87 11.89 6 438474 24607 110126212
Ventricular dysfunction 74.26 11.89 118 438362 7393 110143426
Leukaemia 74.17 11.89 118 438362 7400 110143419
Blood immunoglobulin G decreased 74.01 11.89 99 438381 5301 110145518
Stenotrophomonas infection 73.65 11.89 103 438377 5755 110145064
Therapeutic response shortened 73.55 11.89 14 438466 29569 110121250
Eye swelling 73.45 11.89 20 438460 33028 110117791
General physical health deterioration 73.28 11.89 1215 437265 424080 109726739
Hepatosplenomegaly 73.00 11.89 112 438368 6807 110144012
B-cell lymphoma 72.95 11.89 114 438366 7040 110143779
Flushing 72.92 11.89 195 438285 104541 110046278
Retinitis 72.92 11.89 19 438461 32308 110118511
Respiratory arrest 72.89 11.89 74 438406 58225 110092594
Toxic cardiomyopathy 72.82 11.89 43 438437 746 110150073
Chloroma 72.51 11.89 44 438436 804 110150015
Paraparesis 72.44 11.89 90 438390 4476 110146343
Influenza like illness 72.42 11.89 151 438329 88261 110062558
Bone marrow necrosis 72.39 11.89 35 438445 396 110150423
Pleuroparenchymal fibroelastosis 71.81 11.89 33 438447 330 110150489
Panic attack 71.31 11.89 14 438466 28926 110121893
Cholelithiasis 71.10 11.89 88 438392 63334 110087485
Hypertriglyceridaemia 71.10 11.89 181 438299 15973 110134846
Taste disorder 70.94 11.89 93 438387 65294 110085525
Therapy responder 70.81 11.89 35 438445 417 110150402
Anaphylactic reaction 70.70 11.89 225 438255 114075 110036744
Enterovirus infection 70.64 11.89 70 438410 2700 110148119
Enterococcal sepsis 70.57 11.89 76 438404 3236 110147583
Injection site rash 70.43 11.89 6 438474 23413 110127406
Respiratory tract infection fungal 70.21 11.89 51 438429 1273 110149546
Ocular hyperaemia 70.04 11.89 34 438446 39252 110111567
Metastases to skin 69.85 11.89 64 438416 2235 110148584
Disability 69.65 11.89 17 438463 30206 110120613
Macular degeneration 69.62 11.89 4 438476 21655 110129164
Follicular lymphoma 69.30 11.89 41 438439 714 110150105
Sinus disorder 68.74 11.89 22 438458 32706 110118113
Dry eye 68.42 11.89 72 438408 55721 110095098
Therapy cessation 68.33 11.89 47 438433 44810 110106009
Coma 68.13 11.89 239 438241 117630 110033189
Alveolar proteinosis 67.76 11.89 53 438427 1483 110149336
Pulmonary veno-occlusive disease 67.62 11.89 61 438419 2087 110148732
Rheumatoid nodule 67.61 11.89 3 438477 20293 110130526
Myeloproliferative neoplasm 67.50 11.89 51 438429 1354 110149465
Nail disorder 67.49 11.89 78 438402 57857 110092962
Device dislocation 67.14 11.89 21 438459 31683 110119136
Blood pressure diastolic abnormal 66.83 11.89 11 438469 25804 110125015
Bone marrow infiltration 66.52 11.89 42 438438 826 110149993
Ototoxicity 66.46 11.89 82 438398 4049 110146770
Blood luteinising hormone increased 65.96 11.89 27 438453 198 110150621
Haemoglobin decreased 65.72 11.89 1367 437113 247360 109903459
Hepatic cirrhosis 65.67 11.89 104 438376 67522 110083297
Treatment noncompliance 65.57 11.89 118 438362 72872 110077947
Adenoviral hepatitis 65.38 11.89 44 438436 968 110149851
Proteinuria 65.30 11.89 323 438157 39695 110111124
Dysplasia 65.22 11.89 56 438424 1792 110149027
Hypofibrinogenaemia 65.13 11.89 64 438416 2443 110148376
Babesiosis 64.93 11.89 34 438446 461 110150358
Enteritis 64.83 11.89 195 438285 18961 110131858
Disseminated mucormycosis 64.81 11.89 59 438421 2043 110148776
Human herpesvirus 8 infection 64.62 11.89 56 438424 1815 110149004
Focal nodular hyperplasia 64.57 11.89 42 438438 871 110149948
T-cell lymphoma 64.43 11.89 52 438428 1524 110149295
Movement disorder 64.15 11.89 32 438448 36372 110114447
Steroid diabetes 64.01 11.89 91 438389 5163 110145656
Transient ischaemic attack 63.46 11.89 97 438383 63885 110086934
Depressed mood 63.43 11.89 89 438391 60720 110090099
Paraesthesia oral 63.36 11.89 27 438453 33644 110117175
Urinary tract infection 63.36 11.89 911 437569 325371 109825448
Hip fracture 63.31 11.89 30 438450 35121 110115698
Disseminated toxoplasmosis 63.25 11.89 33 438447 444 110150375
Vasogenic cerebral oedema 63.10 11.89 60 438420 2198 110148621
Device issue 62.93 11.89 29 438451 34506 110116313
Smooth muscle cell neoplasm 62.74 11.89 49 438431 1368 110149451
Ear pain 62.72 11.89 71 438409 53155 110097664
Hallucination, auditory 62.51 11.89 14 438466 26383 110124436
Middle insomnia 62.35 11.89 5 438475 20497 110130322
Poor venous access 62.27 11.89 11 438469 24511 110126308
Poisoning 62.14 11.89 19 438461 29086 110121733
Surgery 61.90 11.89 44 438436 41239 110109580
Hemianopia 61.44 11.89 66 438414 2802 110148017
Tendonitis 61.43 11.89 14 438466 26069 110124750
Anaplastic lymphoma kinase gene mutation 61.37 11.89 23 438457 129 110150690
Angiocentric lymphoma 61.22 11.89 46 438434 1211 110149608
Product dose omission in error 60.91 11.89 10 438470 23502 110127317
Pathogen resistance 60.86 11.89 181 438299 17491 110133328
Gastric disorder 60.80 11.89 28 438452 33329 110117490
Sleep apnoea syndrome 60.79 11.89 43 438437 40404 110110415
Metabolic acidosis 60.54 11.89 198 438282 99546 110051273
T-cell type acute leukaemia 60.54 11.89 29 438451 321 110150498
Haematopoietic stem cell mobilisation 60.42 11.89 31 438449 402 110150417
Remission not achieved 60.16 11.89 33 438447 494 110150325
Systemic scleroderma 60.12 11.89 55 438425 1917 110148902
Malignant genitourinary tract neoplasm 59.91 11.89 17 438463 30 110150789
Peripheral sensorimotor neuropathy 59.82 11.89 76 438404 3867 110146952
Muscular weakness 59.71 11.89 663 437817 247805 109903014
Respiratory depression 59.68 11.89 26 438454 31975 110118844
Foot fracture 59.59 11.89 14 438466 25532 110125287
Extrapyramidal disorder 59.58 11.89 20 438460 28847 110121972
Dermatitis atopic 59.58 11.89 14 438466 25527 110125292
Transaminases increased 59.46 11.89 443 438037 62947 110087872
Cardiomyopathy acute 59.36 11.89 30 438450 376 110150443
Cerebral aspergillosis 58.38 11.89 58 438422 2244 110148575
Meningoencephalitis herpetic 58.13 11.89 59 438421 2343 110148476
Opportunistic infection 58.09 11.89 71 438409 3472 110147347
Refractory cytopenia with unilineage dysplasia 58.03 11.89 39 438441 856 110149963
Necrosis 57.88 11.89 135 438345 11271 110139548
Microangiopathy 57.79 11.89 65 438415 2907 110147912
Accidental exposure to product 57.53 11.89 68 438412 49940 110100879
Computerised tomogram thorax 57.47 11.89 32 438448 494 110150325
Influenza 57.44 11.89 413 438067 168688 109982131
Blood pressure systolic abnormal 57.22 11.89 14 438466 24836 110125983
Hepatomegaly 57.14 11.89 201 438279 21213 110129606
Rash macular 57.00 11.89 42 438438 38644 110112175
Chronic graft versus host disease oral 56.75 11.89 31 438449 460 110150359
Cardio-respiratory arrest 56.68 11.89 251 438229 115585 110035234
Injection site warmth 56.61 11.89 3 438477 17402 110133417
Blood glucose decreased 56.53 11.89 23 438457 29465 110121354
Bone lesion 56.32 11.89 101 438379 6986 110143833
Multiple sclerosis 56.28 11.89 16 438464 25682 110125137
Administration site extravasation 56.21 11.89 50 438430 1679 110149140
Walking aid user 56.06 11.89 15 438465 25060 110125759
Chronic lymphocytic leukaemia transformation 55.98 11.89 26 438454 267 110150552
Body temperature decreased 55.86 11.89 39 438441 36896 110113923
Hyperferritinaemia 55.81 11.89 41 438439 1042 110149777
Mood altered 55.58 11.89 9 438471 21366 110129453
Pneumonia pseudomonal 55.50 11.89 104 438376 7442 110143377
Pneumonia viral 55.46 11.89 131 438349 11026 110139793
Alopecia areata 55.28 11.89 55 438425 2132 110148687
Acute hepatitis B 55.23 11.89 32 438448 535 110150284
Central nervous system fungal infection 55.11 11.89 33 438447 588 110150231
Impaired work ability 55.06 11.89 18 438462 26401 110124418
Impaired quality of life 55.02 11.89 25 438455 29992 110120827
Alveolar soft part sarcoma 54.92 11.89 19 438461 81 110150738
N-terminal prohormone brain natriuretic peptide increased 54.87 11.89 92 438388 6029 110144790
Gastrointestinal necrosis 54.53 11.89 96 438384 6544 110144275
Tinnitus 54.27 11.89 98 438382 60442 110090377
Pneumonia adenoviral 54.19 11.89 33 438447 607 110150212
Secretion discharge 53.83 11.89 8 438472 20236 110130583
Eye pain 53.59 11.89 72 438408 50027 110100792
Fear 53.53 11.89 13 438467 23180 110127639
Coronavirus infection 52.91 11.89 117 438363 9428 110141391
Irritability 52.90 11.89 67 438413 47742 110103077
Product administration error 52.80 11.89 42 438438 37175 110113644
Myelitis transverse 52.75 11.89 56 438424 2345 110148474
Multifocal micronodular pneumocyte hyperplasia 52.74 11.89 18 438462 73 110150746
Hyperviscosity syndrome 52.69 11.89 31 438449 534 110150285
Amyloidosis 52.56 11.89 64 438416 3117 110147702
Pulmonary mucormycosis 52.52 11.89 53 438427 2090 110148729
Product storage error 52.52 11.89 11 438469 21717 110129102
Lower respiratory tract infection fungal 52.37 11.89 36 438444 821 110149998
Abortion spontaneous 52.11 11.89 36 438444 34246 110116573
Periarticular thenar erythema with onycholysis 52.08 11.89 17 438463 58 110150761
Nephrotic syndrome 51.81 11.89 146 438334 13685 110137134
Cytomegalovirus enteritis 51.50 11.89 39 438441 1039 110149780
Ulcer haemorrhage 51.42 11.89 13 438467 22558 110128261
Bronchial polyp 51.25 11.89 18 438462 81 110150738
Acute polyneuropathy 51.08 11.89 34 438446 734 110150085
Autoimmune neutropenia 51.00 11.89 33 438447 678 110150141
Crying 50.76 11.89 19 438461 25609 110125210
Lymphocytosis 50.75 11.89 83 438397 5328 110145491
Kidney infection 50.67 11.89 19 438461 25580 110125239
Neoplasm 50.65 11.89 126 438354 10961 110139858
Laboratory test abnormal 50.64 11.89 60 438420 44019 110106800
Presyncope 50.55 11.89 72 438408 48815 110102004
Extravasation 50.51 11.89 78 438402 4767 110146052
Graft versus host disease in eye 50.30 11.89 28 438452 432 110150387
Acute pulmonary oedema 50.15 11.89 165 438315 16831 110133988
Norovirus infection 50.03 11.89 54 438426 2305 110148514
Needle issue 49.94 11.89 6 438474 17834 110132985
Oligohydramnios 49.87 11.89 70 438410 3924 110146895
Febrile infection 49.77 11.89 74 438406 4374 110146445
Device related sepsis 49.66 11.89 100 438380 7547 110143272
Primary mediastinal large B-cell lymphoma recurrent 49.63 11.89 19 438461 114 110150705
Chronic graft versus host disease in eye 49.58 11.89 27 438453 398 110150421
Geotrichum infection 49.57 11.89 40 438440 1172 110149647
Iron deficiency anaemia 49.50 11.89 32 438448 31527 110119292
Glycosylated haemoglobin increased 49.38 11.89 16 438464 23603 110127216
Infusion site reaction 49.36 11.89 6 438474 17676 110133143
Myocarditis 49.33 11.89 243 438237 29812 110121007
Restless legs syndrome 49.21 11.89 18 438462 24608 110126211
Localised infection 49.02 11.89 59 438421 42989 110107830
Schizophrenia 48.90 11.89 13 438467 21813 110129006
Clostridium colitis 48.88 11.89 63 438417 3252 110147567
Intentional dose omission 48.88 11.89 10 438470 20070 110130749
Psychotic disorder 48.83 11.89 79 438401 50858 110099961
Jugular vein thrombosis 48.80 11.89 81 438399 5264 110145555
Optic atrophy 48.78 11.89 55 438425 2466 110148353
Atelectasis 48.76 11.89 280 438200 36432 110114387
Metastases to pleura 48.70 11.89 50 438430 2013 110148806
Food allergy 48.42 11.89 10 438470 19938 110130881
Full blood count abnormal 48.24 11.89 93 438387 55959 110094860
Hot flush 48.23 11.89 120 438360 65916 110084903
Pneumonia respiratory syncytial viral 48.20 11.89 57 438423 2692 110148127
Delusion 48.09 11.89 17 438463 23738 110127081
Liver injury 47.92 11.89 374 438106 150039 110000780
Vaginal discharge 47.79 11.89 7 438473 17901 110132918
Retinal haemorrhage 47.71 11.89 112 438368 9389 110141430
Hypoproteinaemia 47.60 11.89 85 438395 5860 110144959
Constipation 47.55 11.89 1068 437412 356718 109794101
Vaccination failure 47.35 11.89 54 438426 2452 110148367
Muscle rigidity 47.29 11.89 18 438462 24013 110126806
Chest discomfort 47.05 11.89 451 438029 173397 109977422
Alveolitis 47.03 11.89 72 438408 4367 110146452
SARS-CoV-2 test negative 46.92 11.89 50 438430 2103 110148716
Delayed engraftment 46.91 11.89 23 438457 269 110150550
Quadriplegia 46.66 11.89 69 438411 4058 110146761
Human metapneumovirus test positive 46.61 11.89 22 438458 235 110150584
Small intestinal perforation 46.40 11.89 71 438409 4305 110146514
Empyema 46.35 11.89 81 438399 5489 110145330
Campylobacter infection 46.20 11.89 52 438428 2327 110148492
Skin discolouration 46.14 11.89 77 438403 48969 110101850
Soft tissue infection 46.10 11.89 77 438403 5030 110145789
Rhabdomyosarcoma recurrent 46.00 11.89 19 438461 143 110150676
Cardiac murmur 45.94 11.89 20 438460 24608 110126211
Leukaemic infiltration 45.93 11.89 20 438460 174 110150645
Gas gangrene 45.93 11.89 24 438456 324 110150495
Eye irritation 45.91 11.89 39 438441 33413 110117406
Blast cells present 45.88 11.89 35 438445 943 110149876
Acute leukaemia 45.81 11.89 46 438434 1803 110149016
Paraneoplastic pemphigus 45.74 11.89 20 438460 176 110150643
Clostridium bacteraemia 45.59 11.89 27 438453 471 110150348
Femur fracture 45.48 11.89 66 438414 44403 110106416
Spinal stenosis 45.34 11.89 10 438470 19046 110131773
Rotavirus infection 45.32 11.89 34 438446 893 110149926
Blood culture positive 45.28 11.89 106 438374 8870 110141949
Blood pressure decreased 45.20 11.89 269 438211 114822 110035997
Metastases to chest wall 45.14 11.89 30 438450 646 110150173
Choking 45.09 11.89 4 438476 15106 110135713
Cyst 45.08 11.89 6 438474 16490 110134329
Refractory cancer 45.04 11.89 22 438458 255 110150564
Lung disorder 45.02 11.89 476 438004 179571 109971248
Cytomegalovirus urinary tract infection 44.83 11.89 17 438463 99 110150720
Recall phenomenon 44.65 11.89 40 438440 1356 110149463
Hypersomnia 44.64 11.89 28 438452 28033 110122786
Acute lymphocytic leukaemia refractory 44.59 11.89 20 438460 188 110150631
Adult T-cell lymphoma/leukaemia 44.50 11.89 25 438455 393 110150426
Limb discomfort 44.43 11.89 58 438422 40796 110110023
Maternal exposure timing unspecified 44.35 11.89 14 438466 20999 110129820
Diabetes mellitus inadequate control 44.29 11.89 32 438448 29743 110121076
Hyperlipidaemia 44.25 11.89 46 438434 35802 110115017
Miosis 44.04 11.89 16 438464 21967 110128852
Diffuse large B-cell lymphoma stage IV 44.04 11.89 33 438447 865 110149954
Upper respiratory fungal infection 44.00 11.89 25 438455 402 110150417
Respiratory tract infection 43.98 11.89 456 438024 71161 110079658
Invasive lobular breast carcinoma 43.94 11.89 32 438448 802 110150017
Candida pneumonia 43.89 11.89 35 438445 1008 110149811
Dysphonia 43.85 11.89 154 438326 75775 110075044
Obstructive airways disorder 43.84 11.89 72 438408 46077 110104742
Lung consolidation 43.65 11.89 115 438365 10361 110140458
Immune-mediated hypophysitis 43.60 11.89 34 438446 947 110149872
Disease susceptibility 43.53 11.89 23 438457 318 110150501
Dystonia 43.52 11.89 24 438456 25781 110125038
Amenorrhoea 43.32 11.89 106 438374 9125 110141694
Cutaneous calcification 43.26 11.89 20 438460 203 110150616
Arterial occlusive disease 43.22 11.89 5 438475 15303 110135516
Anger 43.20 11.89 11 438469 18996 110131823
Brain oedema 43.16 11.89 240 438240 30858 110119961
Drug tolerance decreased 43.10 11.89 28 438452 27512 110123307
Eye disorder 43.08 11.89 31 438449 28875 110121944
Deep vein thrombosis 43.08 11.89 787 437693 139100 110011719
Immune thrombocytopenia 42.89 11.89 190 438290 22304 110128515
Akathisia 42.75 11.89 8 438472 17105 110133714
Combined immunodeficiency 42.61 11.89 19 438461 176 110150643
BK polyomavirus test positive 42.56 11.89 22 438458 290 110150529
Bone marrow transplant 42.42 11.89 42 438438 1618 110149201
Enterobacter bacteraemia 42.41 11.89 40 438440 1450 110149369
Pustular psoriasis 42.28 11.89 3 438477 13602 110137217
Glomerulonephritis 42.28 11.89 71 438409 4659 110146160
Chronic graft versus host disease in intestine 42.20 11.89 29 438451 661 110150158
Ankle fracture 42.20 11.89 13 438467 19806 110131013
Tardive dyskinesia 42.18 11.89 3 438477 13576 110137243
Haemolytic uraemic syndrome 42.15 11.89 73 438407 4912 110145907
Actinomycosis 42.08 11.89 38 438442 1302 110149517
Skin haemorrhage 42.00 11.89 23 438457 24804 110126015
Pulmonary arteriopathy 41.93 11.89 16 438464 95 110150724
Psychomotor hyperactivity 41.93 11.89 14 438466 20263 110130556
Hypouricaemia 41.89 11.89 27 438453 551 110150268
Peritonitis pneumococcal 41.66 11.89 12 438468 23 110150796
Disseminated cryptococcosis 41.56 11.89 52 438428 2605 110148214
Bacillus infection 41.55 11.89 41 438439 1573 110149246
Anti-neutrophil cytoplasmic antibody positive vasculitis 41.52 11.89 76 438404 5341 110145478
Thymus enlargement 41.40 11.89 18 438462 156 110150663
Rhinorrhoea 41.36 11.89 238 438242 102428 110048391
Metastases to spleen 41.36 11.89 31 438449 813 110150006
Central nervous system leukaemia 41.34 11.89 27 438453 564 110150255
B-cell lymphoma refractory 41.20 11.89 18 438462 158 110150661
Chronic lymphocytic leukaemia 41.12 11.89 80 438400 5888 110144931
Feeling jittery 41.09 11.89 5 438475 14717 110136102
Hepatopulmonary syndrome 41.09 11.89 19 438461 193 110150626
Trichosporon infection 41.09 11.89 37 438443 1263 110149556
Pulmonary vascular disorder 40.98 11.89 34 438446 1037 110149782
Blood calcium decreased 40.95 11.89 49 438431 35796 110115023
Dermatitis contact 40.82 11.89 4 438476 13949 110136870
Cryptococcosis 40.71 11.89 69 438411 4562 110146257
Product use issue 40.68 11.89 933 437547 310762 109840057
Female genital tract fistula 40.68 11.89 8 438472 16511 110134308
Nail pigmentation 40.64 11.89 23 438457 367 110150452
Hepatic lesion 40.37 11.89 98 438382 8395 110142424
Creatinine renal clearance decreased 40.25 11.89 18 438462 21797 110129022
Blood iron decreased 40.20 11.89 13 438467 19201 110131618
Seasonal allergy 40.12 11.89 14 438466 19708 110131111
CD4 lymphocytes decreased 39.96 11.89 54 438426 2920 110147899
Scratch 39.94 11.89 3 438477 12976 110137843
Abnormal behaviour 39.87 11.89 58 438422 38981 110111838
Bronchiolitis obliterans syndrome 39.86 11.89 28 438452 662 110150157
Retroperitoneal lymphadenopathy 39.83 11.89 38 438442 1398 110149421
Osteoporosis 39.59 11.89 194 438286 86958 110063861
Chronic lymphocytic leukaemia refractory 39.48 11.89 16 438464 114 110150705
Atypical haemolytic uraemic syndrome 39.42 11.89 39 438441 1501 110149318
Hernia 39.40 11.89 14 438466 19486 110131333
Metastatic lymphoma 39.31 11.89 27 438453 615 110150204
Madarosis 39.30 11.89 58 438422 3405 110147414
Portal hypertension 39.29 11.89 98 438382 8539 110142280
Mucosal toxicity 39.28 11.89 28 438452 678 110150141
Morganella infection 39.22 11.89 37 438443 1342 110149477
Enterocolitis 39.16 11.89 164 438316 18785 110132034
Autoimmune lymphoproliferative syndrome 39.07 11.89 19 438461 218 110150601
Gastrointestinal fungal infection 39.04 11.89 29 438451 750 110150069
Hepatitis viral 38.96 11.89 38 438442 1437 110149382
Streptococcal infection 38.90 11.89 113 438367 10777 110140042
Chylothorax 38.72 11.89 34 438446 1122 110149697
Necrotising fasciitis 38.68 11.89 90 438390 7501 110143318
Fungal sepsis 38.59 11.89 46 438434 2191 110148628
Neuroblastoma recurrent 38.58 11.89 25 438455 515 110150304
Oral disorder 38.58 11.89 120 438360 11883 110138936
Epstein-Barr virus test positive 38.52 11.89 36 438444 1290 110149529
Subdural hygroma 38.32 11.89 26 438454 580 110150239
Out of specification test results 38.07 11.89 17 438463 158 110150661
Skin irritation 37.95 11.89 9 438471 16310 110134509
Acinetobacter infection 37.92 11.89 58 438422 3515 110147304
Germ cell cancer 37.91 11.89 18 438462 195 110150624
Marrow hyperplasia 37.89 11.89 41 438439 1755 110149064
Lupus vasculitis 37.86 11.89 26 438454 592 110150227
Morphoea 37.86 11.89 26 438454 592 110150227
High-grade B-cell lymphoma 37.75 11.89 19 438461 236 110150583
Endocarditis bacterial 37.72 11.89 41 438439 1764 110149055
Rhinitis allergic 37.72 11.89 12 438468 17910 110132909
Incorrect product administration duration 37.68 11.89 17 438463 20481 110130338
T-lymphocyte count decreased 37.56 11.89 26 438454 600 110150219
Radiation skin injury 37.53 11.89 39 438441 1593 110149226
Metaplasia 37.52 11.89 26 438454 601 110150218
Chronic hepatitis B 37.47 11.89 25 438455 542 110150277
Invasive ductal breast carcinoma 37.44 11.89 82 438398 6564 110144255
Hallucination, visual 37.42 11.89 62 438418 39543 110111276
Transplant dysfunction 37.37 11.89 94 438386 8234 110142585
Leukaemic infiltration extramedullary 37.33 11.89 21 438459 331 110150488
Salivary gland cancer 37.31 11.89 24 438456 488 110150331
Central nervous system mass 37.28 11.89 29 438451 805 110150014
Platelet transfusion 37.22 11.89 51 438429 2795 110148024
Intervertebral disc protrusion 37.15 11.89 33 438447 27665 110123154
Gastritis bacterial 37.11 11.89 25 438455 551 110150268
Fungal oesophagitis 37.10 11.89 33 438447 1108 110149711
Serositis 36.99 11.89 38 438442 1531 110149288
Herpes simplex encephalitis 36.94 11.89 29 438451 816 110150003
Microangiopathic haemolytic anaemia 36.94 11.89 42 438438 1901 110148918
Thirst 36.88 11.89 20 438460 21687 110129132
Post-acute COVID-19 syndrome 36.87 11.89 38 438442 1537 110149282
Pneumothorax 36.81 11.89 253 438227 35032 110115787
Cytokine storm 36.79 11.89 37 438443 1453 110149366
Acute generalised exanthematous pustulosis 36.75 11.89 20 438460 21644 110129175
Rash erythematous 36.68 11.89 183 438297 81649 110069170
Neuroblastoma 36.57 11.89 21 438459 345 110150474
Unresponsive to stimuli 36.42 11.89 130 438350 63660 110087159
H1N1 influenza 36.36 11.89 52 438428 2966 110147853
Facial paresis 36.25 11.89 77 438403 6036 110144783
Hepatosplenic candidiasis 36.11 11.89 26 438454 640 110150179
Mood swings 35.96 11.89 23 438457 22789 110128030
Lymphadenopathy mediastinal 35.96 11.89 72 438408 5412 110145407
Orthostatic hypotension 35.87 11.89 138 438342 66111 110084708
Left ventricular failure 35.81 11.89 113 438367 11276 110139543
TP53 gene mutation 35.81 11.89 16 438464 149 110150670
Skin burning sensation 35.80 11.89 21 438459 21804 110129015
Blindness 35.76 11.89 257 438223 36102 110114717
Medulloblastoma recurrent 35.74 11.89 17 438463 185 110150634
Respirovirus test positive 35.64 11.89 15 438465 119 110150700
Central nervous system infection 35.60 11.89 39 438441 1693 110149126
Blood bilirubin increased 35.58 11.89 459 438021 75513 110075306
Angina pectoris 35.53 11.89 127 438353 62168 110088651
Infection in an immunocompromised host 35.53 11.89 41 438439 1886 110148933
Acute erythroid leukaemia 35.48 11.89 21 438459 366 110150453
Dementia 35.44 11.89 44 438436 31629 110119190
Haematuria 35.37 11.89 493 437987 82512 110068307
Device breakage 35.35 11.89 6 438474 13763 110137056
Ligament sprain 35.20 11.89 10 438470 16058 110134761
Disseminated cytomegaloviral infection 35.16 11.89 25 438455 603 110150216
Anaphylactic shock 35.10 11.89 97 438383 51449 110099370
Faeces discoloured 35.10 11.89 50 438430 33898 110116921
Inappropriate antidiuretic hormone secretion 34.88 11.89 242 438238 33609 110117210
Nausea 34.83 11.89 4330 434150 1231360 108919459
Therapeutic product effect incomplete 34.79 11.89 651 437829 223154 109927665
Listeriosis 34.67 11.89 49 438431 2765 110148054
Blood loss anaemia 34.65 11.89 14 438466 18011 110132808
Precursor T-lymphoblastic lymphoma/leukaemia 34.60 11.89 15 438465 129 110150690
Cough 34.57 11.89 1487 436993 460154 109690665
Head discomfort 34.55 11.89 16 438464 18984 110131835
Nasal cavity cancer 34.37 11.89 19 438461 289 110150530
Product dispensing error 34.30 11.89 11 438469 16334 110134485
Diabetic ketoacidosis 34.30 11.89 72 438408 41986 110108833
Corynebacterium infection 34.29 11.89 41 438439 1959 110148860
Toxic erythema of chemotherapy 34.26 11.89 21 438459 391 110150428
Immunodeficiency common variable 34.24 11.89 25 438455 629 110150190
Skin mass 34.24 11.89 101 438379 9715 110141104
T-cell lymphoma stage IV 34.22 11.89 16 438464 167 110150652
IVth nerve paralysis 34.07 11.89 25 438455 634 110150185
Syncope 34.05 11.89 581 437899 201955 109948864
Fracture 33.89 11.89 29 438451 24759 110126060
Primary cardiac lymphoma 33.80 11.89 10 438470 22 110150797
Renal cell carcinoma 33.79 11.89 85 438395 7445 110143374
Haematocrit decreased 33.77 11.89 406 438074 65711 110085108
Perineal necrosis 33.73 11.89 16 438464 173 110150646
Herpes simplex reactivation 33.61 11.89 35 438445 1433 110149386
Hypertransaminasaemia 33.53 11.89 187 438293 24068 110126751
Hydrothorax 33.50 11.89 37 438443 1621 110149198
Hiatus hernia 33.43 11.89 36 438444 27570 110123249
Splenic candidiasis 33.41 11.89 13 438467 82 110150737
Graft complication 33.40 11.89 31 438449 1101 110149718
Encephalitis enteroviral 33.38 11.89 18 438462 260 110150559
Liver function test abnormal 33.36 11.89 150 438330 68800 110082019
Lymphangiosis carcinomatosa 33.25 11.89 45 438435 2437 110148382
IIIrd nerve paralysis 33.23 11.89 34 438446 1363 110149456
Viral load increased 33.16 11.89 53 438427 3337 110147482
Melaena 33.02 11.89 150 438330 68607 110082212
Heart rate irregular 33.00 11.89 53 438427 34221 110116598
Malnutrition 32.98 11.89 203 438277 27076 110123743
Chromosome analysis abnormal 32.96 11.89 18 438462 267 110150552
Bacteroides bacteraemia 32.95 11.89 14 438466 114 110150705
Epilepsy 32.93 11.89 247 438233 99962 110050857
Musculoskeletal disorder 32.88 11.89 25 438455 22639 110128180
Large intestine perforation 32.88 11.89 142 438338 16487 110134332
Wall motion score index abnormal 32.81 11.89 27 438453 814 110150005
Autonomic neuropathy 32.81 11.89 43 438437 2257 110148562
Acute myocardial infarction 32.80 11.89 196 438284 83581 110067238
Carpal tunnel syndrome 32.73 11.89 25 438455 22585 110128234
Aphasia 32.68 11.89 368 438112 58629 110092190
Metastatic neoplasm 32.56 11.89 72 438408 5801 110145018
Enterocolitis infectious 32.53 11.89 53 438427 3391 110147428
Glomerulonephritis rapidly progressive 32.51 11.89 42 438438 2173 110148646
Viral infection 32.47 11.89 338 438142 52801 110098018
Glaucoma 32.46 11.89 25 438455 22492 110128327
Blood disorder 32.39 11.89 99 438381 9711 110141108
Abdominal neoplasm 32.38 11.89 25 438455 686 110150133
Gastroenteritis viral 32.27 11.89 46 438434 31180 110119639
Abscess bacterial 32.27 11.89 28 438452 909 110149910
Squamous cell carcinoma 32.27 11.89 152 438328 18311 110132508
Clonal evolution 32.18 11.89 17 438463 235 110150584
Antithrombin III decreased 32.15 11.89 22 438458 498 110150321
Gallbladder disorder 32.07 11.89 22 438458 21007 110129812
Emotional disorder 31.98 11.89 12 438468 16148 110134671
Transplantation complication 31.93 11.89 21 438459 444 110150375
Acute biphenotypic leukaemia 31.80 11.89 15 438465 160 110150659
Central nervous system enteroviral infection 31.68 11.89 13 438467 96 110150723
Retching 31.67 11.89 26 438454 22656 110128163
Transitional cell carcinoma 31.55 11.89 50 438430 3125 110147694
Tuberculosis of central nervous system 31.51 11.89 22 438458 515 110150304
Blood potassium increased 31.46 11.89 52 438428 33197 110117622
Herpes oesophagitis 31.42 11.89 20 438460 399 110150420
Mucosal disorder 31.40 11.89 60 438420 4357 110146462
Chromosomal deletion 31.32 11.89 15 438465 166 110150653
Lung adenocarcinoma 31.30 11.89 96 438384 9435 110141384
Spondylitis 31.28 11.89 4 438476 11334 110139485
Meningoencephalitis viral 31.21 11.89 22 438458 523 110150296
Lymphadenitis 31.20 11.89 68 438412 5425 110145394
Systemic inflammatory response syndrome 31.06 11.89 118 438362 12925 110137894
West Nile viral infection 31.05 11.89 32 438448 1294 110149525
Mastectomy 31.02 11.89 34 438446 1477 110149342
Body height decreased 30.98 11.89 3 438477 10560 110140259
Septic embolus 30.90 11.89 42 438438 2284 110148535
Transformation to acute myeloid leukaemia 30.80 11.89 34 438446 1489 110149330
Rotator cuff syndrome 30.76 11.89 14 438466 16780 110134039
Hepatic vein occlusion 30.75 11.89 18 438462 307 110150512
Cerebral venous sinus thrombosis 30.74 11.89 47 438433 2848 110147971
Gastroenteritis norovirus 30.69 11.89 53 438427 3558 110147261
Hepatitis C RNA increased 30.57 11.89 20 438460 419 110150400
Evans syndrome 30.57 11.89 25 438455 747 110150072
Oropharyngeal pain 30.52 11.89 366 438114 134910 110015909
Affect lability 30.48 11.89 18 438462 18619 110132200
Hypertensive crisis 30.39 11.89 31 438449 24341 110126478
Hepatic candidiasis 30.37 11.89 13 438467 108 110150711
Thinking abnormal 30.37 11.89 11 438469 15129 110135690
Gastric perforation 30.29 11.89 63 438417 4866 110145953
Foetal growth restriction 30.27 11.89 48 438432 3002 110147817
Metastases to peritoneum 30.23 11.89 68 438412 5542 110145277
Stenotrophomonas sepsis 30.23 11.89 16 438464 222 110150597
Ankylosing spondylitis 30.22 11.89 12 438468 15600 110135219
Neurological decompensation 30.16 11.89 77 438403 6806 110144013
Airway remodelling 30.14 11.89 27 438453 915 110149904
Drug tolerance 30.11 11.89 14 438466 16571 110134248
Sputum discoloured 30.05 11.89 40 438440 27905 110122914
Cytomegalovirus enterocolitis 30.02 11.89 41 438439 2240 110148579
Bone density decreased 29.97 11.89 13 438467 16029 110134790
Dehydration 29.97 11.89 861 437619 278650 109872169
Stenotrophomonas bacteraemia 29.94 11.89 17 438463 273 110150546
Adenocarcinoma gastric 29.86 11.89 39 438441 2040 110148779
Leukoerythroblastosis 29.76 11.89 18 438462 327 110150492
Tissue infiltration 29.69 11.89 28 438452 1015 110149804
Escherichia urinary tract infection 29.68 11.89 135 438345 16027 110134792
Salivary hypersecretion 29.68 11.89 16 438464 17405 110133414
Respiratory tract infection bacterial 29.66 11.89 42 438438 2374 110148445
Carbohydrate antigen 15-3 increased 29.65 11.89 34 438446 1553 110149266
Ileal perforation 29.61 11.89 32 438448 1368 110149451
Pemphigoid 29.55 11.89 21 438459 19686 110131133
Blindness cortical 29.53 11.89 29 438451 1106 110149713
Cataract 29.53 11.89 189 438291 79296 110071523
Achromobacter infection 29.51 11.89 17 438463 281 110150538
Skin fissures 29.50 11.89 32 438448 24426 110126393
Monocyte count decreased 29.48 11.89 54 438426 3797 110147022
Gastrointestinal mucormycosis 29.35 11.89 24 438456 717 110150102
Cardiac septal defect 29.20 11.89 27 438453 954 110149865
Left ventricular dilatation 29.20 11.89 32 438448 1390 110149429
Clostridial infection 29.19 11.89 72 438408 6230 110144589
Varicella 29.19 11.89 53 438427 3702 110147117
Internal haemorrhage 29.17 11.89 3 438477 10068 110140751
Superior sagittal sinus thrombosis 29.15 11.89 29 438451 1124 110149695
Lymphomatoid papulosis 29.13 11.89 19 438461 396 110150423
Upper limb fracture 29.10 11.89 24 438456 20864 110129955
Hydrocephalus 29.09 11.89 99 438381 10276 110140543
Weight fluctuation 28.97 11.89 27 438453 22118 110128701
Pneumonia pneumococcal 28.82 11.89 62 438418 4903 110145916
Pyomyositis 28.81 11.89 24 438456 736 110150083
Lymphocytic leukaemia 28.74 11.89 17 438463 296 110150523
Anal inflammation 28.61 11.89 42 438438 2454 110148365
Blood test abnormal 28.59 11.89 43 438437 28511 110122308
Blood pressure abnormal 28.56 11.89 28 438452 22396 110128423
Eating disorder 28.52 11.89 49 438431 30809 110120010
Red blood cell schistocytes present 28.51 11.89 24 438456 747 110150072
Natural killer-cell leukaemia 28.43 11.89 12 438468 96 110150723
Embolism 28.39 11.89 134 438346 16155 110134664
Hypokalaemia 28.36 11.89 935 437545 181513 109969306
Immune-mediated cytopenia 28.34 11.89 17 438463 304 110150515
Lung diffusion test decreased 28.33 11.89 34 438446 1631 110149188
Aspiration bone marrow 28.24 11.89 14 438466 168 110150651
Immune-mediated hypothyroidism 28.19 11.89 45 438435 2830 110147989
Pulmonary tuberculosis 28.12 11.89 90 438390 9049 110141770
Haemolytic anaemia 28.07 11.89 160 438320 20760 110130059
Temperature regulation disorder 28.06 11.89 8 438472 12818 110138001
Eosinophilia 28.06 11.89 126 438354 57810 110093009
Cardiac disorder 28.03 11.89 182 438298 76098 110074721
Meningitis 27.98 11.89 106 438374 11596 110139223
Electrocardiogram abnormal 27.97 11.89 20 438460 18689 110132130
Metastases to the mediastinum 27.93 11.89 24 438456 769 110150050
Bladder hypertrophy 27.92 11.89 28 438452 1096 110149723
Therapeutic response unexpected 27.88 11.89 32 438448 23811 110127008
Feeling cold 27.87 11.89 58 438422 33929 110116890
Blood urine present 27.85 11.89 33 438447 24212 110126607
Paraplegia 27.84 11.89 70 438410 6130 110144689
Viral test positive 27.77 11.89 25 438455 853 110149966
Acute lung injury 27.77 11.89 47 438433 3104 110147715
Lymphoplasmacytoid lymphoma/immunocytoma recurrent 27.73 11.89 9 438471 30 110150789
Laryngitis fungal 27.67 11.89 14 438466 176 110150643
Angioimmunoblastic T-cell lymphoma 27.63 11.89 22 438458 632 110150187
Hepatitis B surface antigen positive 27.60 11.89 14 438466 177 110150642
Coronary artery occlusion 27.58 11.89 14 438466 15758 110135061
Necrotising gastritis 27.55 11.89 11 438469 75 110150744
Haemolysis 27.51 11.89 129 438351 15510 110135309
Cell-mediated immune deficiency 27.49 11.89 15 438465 222 110150597
Plasmablastic lymphoma 27.48 11.89 24 438456 786 110150033
Abdominal compartment syndrome 27.44 11.89 36 438444 1891 110148928
Campylobacter gastroenteritis 27.41 11.89 36 438444 1893 110148926
Tooth fracture 27.39 11.89 9 438471 13158 110137661
Squamous cell carcinoma of the oral cavity 27.35 11.89 23 438457 715 110150104
Atopy 27.30 11.89 28 438452 1126 110149693
Facial paralysis 27.29 11.89 177 438303 24037 110126782
Abdominal abscess 27.27 11.89 87 438393 8732 110142087
Mucosal infection 27.23 11.89 20 438460 508 110150311
Fibrinous bronchitis 27.21 11.89 13 438467 143 110150676
Large intestine polyp 27.07 11.89 13 438467 15104 110135715
Scrotal cellulitis 27.07 11.89 11 438469 79 110150740
Diffuse alopecia 27.06 11.89 30 438450 1320 110149499
Pulmonary fibrosis 27.06 11.89 266 438214 101776 110049043
Acute interstitial pneumonitis 27.05 11.89 31 438449 1415 110149404
Emphysematous cholecystitis 27.02 11.89 12 438468 110 110150709
Laryngopharyngitis 27.02 11.89 12 438468 110 110150709
Immunoglobulins decreased 26.97 11.89 40 438440 2359 110148460
Arteriosclerosis coronary artery 26.96 11.89 36 438444 25082 110125737
Vascular injury 26.96 11.89 28 438452 1143 110149676
Enterobacter sepsis 26.95 11.89 30 438450 1326 110149493
Mucoepidermoid carcinoma 26.95 11.89 11 438469 80 110150739
Diffuse large B-cell lymphoma stage II 26.83 11.89 12 438468 112 110150707
Coagulopathy 26.81 11.89 264 438216 40647 110110172
Proctitis 26.77 11.89 17 438463 16910 110133909
Vena cava thrombosis 26.76 11.89 49 438431 3445 110147374
Intracardiac thrombus 26.75 11.89 55 438425 4213 110146606
Drug level increased 26.74 11.89 98 438382 47621 110103198
Drug dose omission by device 26.74 11.89 12 438468 14504 110136315
Meningitis enterococcal 26.73 11.89 14 438466 190 110150629
Vocal cord paralysis 26.71 11.89 45 438435 2961 110147858
Asthenia 26.70 11.89 2360 436120 686639 109464180
Vitamin B12 deficiency 26.67 11.89 4 438476 10051 110140768
Body mass index abnormal 26.58 11.89 25 438455 903 110149916
Cryptococcal fungaemia 26.53 11.89 16 438464 289 110150530
Cardiac failure acute 26.52 11.89 175 438305 23903 110126916
Anal squamous cell carcinoma 26.44 11.89 24 438456 828 110149991
Faeces soft 26.43 11.89 6 438474 11204 110139615
Gangrene 26.42 11.89 16 438464 16325 110134494
Colitis microscopic 26.41 11.89 10 438470 13384 110137435
Metapneumovirus infection 26.40 11.89 40 438440 2404 110148415
Appendiceal abscess 26.32 11.89 18 438462 407 110150412
Drug level decreased 26.23 11.89 21 438459 18527 110132292
Myasthenia gravis 26.11 11.89 28 438452 21483 110129336
Renal impairment 26.10 11.89 953 437527 187492 109963327
Axillary lymphadenectomy 26.06 11.89 11 438469 88 110150731
Lentigo 26.04 11.89 23 438457 765 110150054
Arteritis 26.00 11.89 27 438453 1102 110149717
Positron emission tomogram abnormal 25.99 11.89 19 438461 479 110150340
Primary mediastinal large B-cell lymphoma 25.98 11.89 10 438470 61 110150758
Human herpesvirus 7 infection 25.97 11.89 14 438466 202 110150617
Bacillus bacteraemia 25.93 11.89 15 438465 250 110150569
Cerebral fungal infection 25.91 11.89 22 438458 693 110150126
Sertoli-cell-only syndrome 25.90 11.89 9 438471 39 110150780
Gastric stenosis 25.85 11.89 14 438466 204 110150615
Skin abrasion 25.85 11.89 16 438464 16135 110134684
Metastases to diaphragm 25.85 11.89 10 438470 62 110150757
Device related bacteraemia 25.81 11.89 28 438452 1202 110149617
Citrobacter bacteraemia 25.79 11.89 8 438472 22 110150797
Erythropoiesis abnormal 25.77 11.89 21 438459 624 110150195
Aspergilloma 25.76 11.89 23 438457 776 110150043
Dysgeusia 25.70 11.89 167 438313 69818 110081001
Hormone receptor positive breast cancer 25.65 11.89 20 438460 557 110150262
Mydriasis 25.62 11.89 30 438450 22127 110128692
Pelvic fracture 25.61 11.89 12 438468 14142 110136677
Histiocytic sarcoma 25.53 11.89 11 438469 93 110150726
Superior vena cava syndrome 25.51 11.89 29 438451 1312 110149507
Clear cell renal cell carcinoma 25.48 11.89 42 438438 2714 110148105
Neuroendocrine carcinoma of the skin 25.47 11.89 33 438447 1712 110149107
Osteonecrosis of jaw 25.47 11.89 297 438183 47720 110103099
Ureteric dilatation 25.46 11.89 15 438465 259 110150560
Pneumonia aspiration 25.39 11.89 203 438277 81030 110069789
Central nervous system vasculitis 25.28 11.89 32 438448 1622 110149197
Coordination abnormal 25.25 11.89 38 438442 25190 110125629
Mucosal haemorrhage 25.24 11.89 44 438436 2976 110147843
Abnormal loss of weight 25.19 11.89 5 438475 10252 110140567
Hair follicle tumour benign 25.18 11.89 18 438462 438 110150381
Aspiration bone marrow abnormal 25.17 11.89 13 438467 171 110150648
Citrobacter infection 25.15 11.89 29 438451 1333 110149486
Anosmia 25.12 11.89 9 438471 12463 110138356
Tension headache 25.12 11.89 4 438476 9614 110141205
Procalcitonin increased 25.11 11.89 52 438428 4004 110146815
Tumour necrosis 25.09 11.89 39 438441 2397 110148422
Injection site induration 25.09 11.89 7 438473 11376 110139443
Giardiasis 25.08 11.89 20 438460 576 110150243
Hypopnoea 25.08 11.89 7 438473 11373 110139446
Cancer fatigue 25.07 11.89 17 438463 379 110150440
Klebsiella test positive 24.97 11.89 39 438441 2407 110148412
Pain in jaw 24.96 11.89 111 438369 51066 110099753
Tooth development disorder 24.95 11.89 10 438470 69 110150750
Dysstasia 24.83 11.89 59 438421 32927 110117892
Lethargy 24.78 11.89 244 438236 93332 110057487
Oroantral fistula 24.72 11.89 17 438463 388 110150431
Large intestinal ulcer perforation 24.71 11.89 10 438470 71 110150748
Hepatic necrosis 24.66 11.89 91 438389 9831 110140988
Product administered to patient of inappropriate age 24.60 11.89 79 438401 7957 110142862
Fat embolism syndrome 24.57 11.89 12 438468 139 110150680
Post procedural infection 24.54 11.89 12 438468 13797 110137022
VIth nerve paresis 24.50 11.89 12 438468 140 110150679
Neutrophil percentage decreased 24.36 11.89 24 438456 919 110149900
Toxic neuropathy 24.33 11.89 26 438454 1097 110149722
Granulomatosis with polyangiitis 24.31 11.89 47 438433 3443 110147376
Central nervous system lesion 24.29 11.89 124 438356 15429 110135390
Electrolyte imbalance 24.29 11.89 239 438241 36789 110114030
Quadriparesis 24.20 11.89 56 438424 4651 110146168
Rib fracture 24.17 11.89 62 438418 33708 110117111
Immune-mediated hyperthyroidism 24.16 11.89 20 438460 608 110150211
Arteriosclerosis 24.13 11.89 38 438442 24729 110126090
Erythropenia 24.11 11.89 18 438462 469 110150350
Autologous haematopoietic stem cell transplant 24.11 11.89 11 438469 108 110150711
Forced expiratory volume decreased 24.11 11.89 11 438469 13165 110137654
Nasal abscess 24.09 11.89 13 438467 188 110150631
Myoclonus 24.07 11.89 60 438420 32938 110117881
Diverticulum 24.00 11.89 16 438464 15510 110135309
Pathological fracture 23.99 11.89 103 438377 11929 110138890
Neurologic neglect syndrome 23.98 11.89 4 438476 9294 110141525
Aspergillus test positive 23.98 11.89 25 438455 1025 110149794
Drug level above therapeutic 23.96 11.89 8 438472 11580 110139239
Cryptosporidiosis infection 23.95 11.89 26 438454 1117 110149702
Malignant syphilis 23.94 11.89 9 438471 51 110150768
Hilar lymphadenopathy 23.92 11.89 37 438443 2265 110148554
Metastases to retroperitoneum 23.87 11.89 17 438463 411 110150408
Ulcer 23.87 11.89 89 438391 43027 110107792
Ureaplasma infection 23.77 11.89 30 438450 1516 110149303
Lumbosacral radiculoplexus neuropathy 23.76 11.89 11 438469 112 110150707
Mediastinum neoplasm 23.76 11.89 11 438469 112 110150707
Flagellate dermatitis 23.76 11.89 15 438465 295 110150524
Corynebacterium sepsis 23.75 11.89 14 438466 242 110150577
Lennox-Gastaut syndrome 23.71 11.89 15 438465 296 110150523
Cystoid macular oedema 23.67 11.89 41 438439 2759 110148060
Metastases to spine 23.65 11.89 60 438420 5283 110145536
Adult T-cell lymphoma/leukaemia recurrent 23.65 11.89 9 438471 53 110150766
Acute megakaryocytic leukaemia 23.65 11.89 9 438471 53 110150766
Central nervous system lupus 23.63 11.89 28 438452 1325 110149494
Osteomyelitis bacterial 23.63 11.89 19 438461 554 110150265
Borrelia infection 23.62 11.89 15 438465 298 110150521
Leukaemic lymphoma 23.58 11.89 10 438470 81 110150738
Epstein Barr virus positive mucocutaneous ulcer 23.51 11.89 26 438454 1141 110149678
JC virus CSF test positive 23.50 11.89 13 438467 198 110150621
Enthesopathy 23.49 11.89 10 438470 12468 110138351
Myelodysplastic syndrome transformation 23.38 11.89 22 438458 795 110150024
Neurological symptom 23.38 11.89 123 438357 15485 110135334
Blood pressure diastolic increased 23.36 11.89 24 438456 18783 110132036
Coma scale abnormal 23.35 11.89 5 438475 9721 110141098
Cardiac amyloidosis 23.28 11.89 41 438439 2796 110148023
Splenic marginal zone lymphoma 23.27 11.89 10 438470 84 110150735
Monoparesis 23.22 11.89 54 438426 4499 110146320
Cholecystectomy 23.18 11.89 7 438473 10802 110140017
Overlap syndrome 23.14 11.89 4 438476 9055 110141764
Paresis 23.13 11.89 56 438424 4788 110146031
Metastases to muscle 23.12 11.89 16 438464 369 110150450
Bradykinesia 23.11 11.89 7 438473 10781 110140038
Bone sarcoma 23.07 11.89 10 438470 86 110150733
Anisometropia 22.97 11.89 10 438470 87 110150732
Lymphadenitis viral 22.97 11.89 10 438470 87 110150732
Herpes zoster infection neurological 22.94 11.89 18 438462 506 110150313
Device leakage 22.90 11.89 18 438462 16030 110134789
Tooth disorder 22.84 11.89 52 438428 29457 110121362
Papilloedema 22.83 11.89 73 438407 7336 110143483
Meningitis viral 22.77 11.89 37 438443 2362 110148457
Renal amyloidosis 22.77 11.89 15 438465 318 110150501
Superinfection bacterial 22.75 11.89 37 438443 2364 110148455
Angina unstable 22.74 11.89 19 438461 16413 110134406
Pulmonary arterial hypertension 22.74 11.89 213 438267 32355 110118464
Anaplastic large cell lymphoma T- and null-cell types recurrent 22.71 11.89 9 438471 60 110150759
Dizziness postural 22.66 11.89 15 438465 14594 110136225
Urinary tract infection bacterial 22.64 11.89 77 438403 7990 110142829
Ketoacidosis 22.61 11.89 6 438474 10081 110140738
Lineage switch leukaemia 22.59 11.89 9 438471 61 110150758
Seizure 22.55 11.89 1083 437397 220102 109930717
Hepatitis B DNA increased 22.54 11.89 22 438458 833 110149986
Hepatic infection fungal 22.53 11.89 15 438465 324 110150495
Increased appetite 22.40 11.89 16 438464 14961 110135858
Spinal cord disorder 22.38 11.89 35 438445 2163 110148656
Diabetes mellitus 22.37 11.89 269 438211 99112 110051707
Hyperleukocytosis 22.37 11.89 45 438435 3394 110147425
Viral sepsis 22.35 11.89 13 438467 219 110150600
Genitourinary tract neoplasm 22.34 11.89 9 438471 63 110150756
Thyroiditis 22.33 11.89 67 438413 6506 110144313
Haematoma 22.26 11.89 138 438342 58338 110092481
Mantle cell lymphoma refractory 22.26 11.89 11 438469 131 110150688
Polyp 22.25 11.89 6 438474 9974 110140845
Escherichia test positive 22.25 11.89 46 438434 3538 110147281
Myocardial oedema 22.23 11.89 19 438461 604 110150215
Brain stem syndrome 22.22 11.89 27 438453 1312 110149507
Oesophagitis 22.20 11.89 192 438288 28523 110122296
Dermatomyositis 22.19 11.89 52 438428 4354 110146465
Prohormone brain natriuretic peptide increased 22.18 11.89 16 438464 395 110150424
Enterovirus test positive 22.17 11.89 15 438465 333 110150486
Musculoskeletal discomfort 22.10 11.89 37 438443 23501 110127318
Hand fracture 22.08 11.89 3 438477 8119 110142700
Chronic hepatitis 22.04 11.89 31 438449 1741 110149078
Prostatic specific antigen increased 22.04 11.89 11 438469 12500 110138319
Blood potassium decreased 22.03 11.89 125 438355 53989 110096830
Haemorrhage intracranial 22.03 11.89 193 438287 28776 110122043
Eosinophil count decreased 22.03 11.89 63 438417 5955 110144864
Respiratory tract infection viral 21.97 11.89 62 438418 5816 110145003
Jejunal stenosis 21.97 11.89 11 438469 135 110150684
Lymphocyte adoptive therapy 21.90 11.89 11 438469 136 110150683
Thrombotic thrombocytopenic purpura 21.85 11.89 70 438410 7041 110143778
Pleural mass 21.85 11.89 10 438470 99 110150720
Epstein-Barr virus antigen positive 21.85 11.89 10 438470 99 110150720
Hepatic infarction 21.77 11.89 23 438457 958 110149861
Soft tissue neoplasm 21.76 11.89 10 438470 100 110150719
Papilloma viral infection 21.70 11.89 34 438446 2104 110148715
Herpes zoster meningoencephalitis 21.69 11.89 24 438456 1054 110149765
Cellulitis gangrenous 21.66 11.89 16 438464 410 110150409
Mantle cell lymphoma 21.64 11.89 30 438450 1662 110149157
Aphonia 21.63 11.89 12 438468 12848 110137971
Haemorrhagic stroke 21.60 11.89 14 438466 13775 110137044
Meningitis tuberculous 21.59 11.89 26 438454 1252 110149567
Cutaneous mucormycosis 21.55 11.89 20 438460 710 110150109
Hepatic calcification 21.52 11.89 15 438465 350 110150469
Ameloblastoma 21.50 11.89 10 438470 103 110150716
Ileus 21.47 11.89 201 438279 30528 110120291
Blood lactate dehydrogenase abnormal 21.46 11.89 19 438461 634 110150185
Post procedural complication 21.43 11.89 46 438434 26612 110124207
Angioimmunoblastic T-cell lymphoma recurrent 21.42 11.89 7 438473 24 110150795
Viral sinusitis 21.41 11.89 14 438466 293 110150526
Liver disorder 21.40 11.89 416 438064 141827 110008992
Primitive neuroectodermal tumour 21.33 11.89 8 438472 45 110150774
Listeria sepsis 21.30 11.89 21 438459 805 110150014
Pyloric stenosis 21.28 11.89 18 438462 564 110150255
Sexual dysfunction 21.28 11.89 4 438476 8526 110142293
Cranial nerve disorder 21.28 11.89 26 438454 1271 110149548
Hepatosplenic T-cell lymphoma 21.27 11.89 23 438457 984 110149835
Increased tendency to bruise 21.23 11.89 10 438470 11748 110139071
Cerebrosclerosis 21.20 11.89 7 438473 25 110150794
Hypomania 21.20 11.89 7 438473 10203 110140616
Cardiac tamponade 21.18 11.89 95 438385 11212 110139607
Tooth malformation 21.15 11.89 11 438469 147 110150672
Pneumoperitoneum 21.15 11.89 48 438432 3936 110146883
Ureteric compression 21.12 11.89 14 438466 300 110150519
Rhinocerebral mucormycosis 21.08 11.89 28 438452 1489 110149330
Ovarian disorder 21.07 11.89 18 438462 572 110150247
Deformity 21.04 11.89 7 438473 10153 110140666
Mesangioproliferative glomerulonephritis 20.98 11.89 13 438467 247 110150572
Central nervous system necrosis 20.98 11.89 16 438464 431 110150388
PIK3CA-activated mutation 20.97 11.89 19 438461 654 110150165
Brain herniation 20.96 11.89 80 438400 8783 110142036
Urinary retention 20.93 11.89 176 438304 69507 110081312
Gingivitis ulcerative 20.93 11.89 17 438463 503 110150316
T-cell lymphoma recurrent 20.90 11.89 9 438471 76 110150743
Cushingoid 20.89 11.89 97 438383 11615 110139204
Troponin I increased 20.86 11.89 58 438422 5394 110145425
Meningitis aseptic 20.85 11.89 86 438394 9784 110141035
Neuralgia 20.83 11.89 110 438370 48368 110102451
Renal cancer 20.74 11.89 13 438467 13021 110137798
Primary immunodeficiency syndrome 20.70 11.89 9 438471 78 110150741
Necrotising colitis 20.67 11.89 30 438450 1735 110149084
Glottis carcinoma 20.66 11.89 6 438474 12 110150807
Cardiac imaging procedure abnormal 20.66 11.89 6 438474 12 110150807
Unintentional medical device removal 20.65 11.89 80 438400 8843 110141976
VIth nerve paralysis 20.64 11.89 30 438450 1737 110149082
Cytomegalovirus gastritis 20.61 11.89 19 438461 669 110150150
Pseudomonas test positive 20.60 11.89 35 438445 2319 110148500
Triple negative breast cancer 20.59 11.89 17 438463 515 110150304
Infective aortitis 20.50 11.89 9 438471 80 110150739
Anaplastic large cell lymphoma T- and null-cell types 20.48 11.89 12 438468 205 110150614
Aeromonas infection 20.45 11.89 17 438463 520 110150299
Joint effusion 20.43 11.89 32 438448 20873 110129946
Hippocampal sclerosis 20.38 11.89 12 438468 207 110150612
Haemodynamic instability 20.36 11.89 158 438322 22730 110128089
Pneumaturia 20.36 11.89 8 438472 52 110150767
Malignant pleural effusion 20.28 11.89 48 438432 4045 110146774
Kaposi's sarcoma 20.28 11.89 19 438461 683 110150136
Paranoia 20.25 11.89 36 438444 22338 110128481
Hypermetabolism 20.22 11.89 18 438462 605 110150214
Skin exfoliation 20.21 11.89 236 438244 87415 110063404
Metastases to eye 20.19 11.89 14 438466 324 110150495
Plasma cells increased 20.17 11.89 10 438470 120 110150699
Adenocarcinoma of colon 20.13 11.89 62 438418 6106 110144713
Arrhythmogenic right ventricular dysplasia 20.12 11.89 9 438471 84 110150735
Tracheo-oesophageal fistula 20.12 11.89 19 438461 690 110150129
Pneumothorax spontaneous 20 11.89 30 438450 1787 110149032
Molluscum contagiosum 20.00 11.89 18 438462 614 110150205
Mycobacterium kansasii infection 19.96 11.89 15 438465 395 110150424
Frustration tolerance decreased 19.94 11.89 5 438475 8726 110142093
Adenocarcinoma 19.93 11.89 49 438431 4231 110146588
Peritonitis viral 19.86 11.89 8 438472 56 110150763
Pericardial effusion malignant 19.84 11.89 13 438467 273 110150546
Thyroid dermatopathy 19.84 11.89 7 438473 32 110150787
Disturbance in attention 19.81 11.89 154 438326 61841 110088978
Herpes simplex test positive 19.80 11.89 18 438462 622 110150197
Cerebellar haemangioma 19.76 11.89 9 438471 88 110150731
Granuloma skin 19.76 11.89 10 438470 11273 110139546
CSF volume increased 19.74 11.89 8 438472 57 110150762
Bradypnoea 19.67 11.89 5 438475 8644 110142175
Inflammatory myofibroblastic tumour 19.65 11.89 12 438468 222 110150597
Spinal disorder 19.65 11.89 11 438469 11717 110139102
Interleukin level increased 19.63 11.89 28 438452 1593 110149226
Neuromuscular toxicity 19.61 11.89 15 438465 406 110150413
Viral vasculitis 19.60 11.89 12 438468 223 110150596
Staphylococcus test positive 19.51 11.89 69 438411 7301 110143518
Muscle strain 19.51 11.89 10 438470 11192 110139627
Anal infection 19.51 11.89 12 438468 225 110150594
Executive dysfunction 19.48 11.89 15 438465 410 110150409
Fusobacterium infection 19.46 11.89 12 438468 226 110150593
Mass 19.45 11.89 139 438341 19491 110131328
Mitral valve incompetence 19.42 11.89 210 438270 33119 110117700
Low density lipoprotein increased 19.37 11.89 9 438471 10657 110140162
KMT2A gene mutation 19.34 11.89 7 438473 35 110150784
Varicocele 19.34 11.89 7 438473 35 110150784
Meningitis enteroviral 19.33 11.89 9 438471 93 110150726
Herpes zoster reactivation 19.32 11.89 15 438465 415 110150404
Metastases to heart 19.26 11.89 15 438465 417 110150402
Epididymitis 19.23 11.89 35 438445 2449 110148370
Device electrical impedance issue 19.23 11.89 5 438475 5 110150814
Pulmonary thrombosis 19.22 11.89 16 438464 13847 110136972
Li-Fraumeni syndrome 19.21 11.89 6 438474 17 110150802
Ewing's sarcoma recurrent 19.21 11.89 6 438474 17 110150802
Hair texture abnormal 19.19 11.89 46 438434 3908 110146911
Speech disorder 19.18 11.89 154 438326 61415 110089404
Cerebral cavernous malformation 19.18 11.89 7 438473 36 110150783
Chromosomal mutation 19.17 11.89 8 438472 62 110150757
Roseolovirus test positive 19.16 11.89 13 438467 290 110150529
Herpes simplex viraemia 19.12 11.89 18 438462 651 110150168
Obstruction gastric 19.07 11.89 31 438449 1980 110148839
Bronchospasm 19.06 11.89 59 438421 30180 110120639
Microscopic polyangiitis 19.04 11.89 16 438464 497 110150322
Capnocytophaga infection 19.03 11.89 11 438469 183 110150636
Peripheral T-cell lymphoma unspecified stage IV 19.02 11.89 7 438473 37 110150782
Parasitic pneumonia 19.02 11.89 7 438473 37 110150782
Poor quality sleep 18.99 11.89 53 438427 28024 110122795
Glomerulonephritis membranoproliferative 18.99 11.89 20 438460 830 110149989
Death 18.98 11.89 2454 436026 696415 109454404
Hair colour changes 18.98 11.89 51 438429 4650 110146169
Intestinal atresia 18.95 11.89 8 438472 64 110150755
Mucoepidermoid carcinoma of salivary gland 18.94 11.89 10 438470 138 110150681
Drug specific antibody present 18.94 11.89 5 438475 8429 110142390
Essential hypertension 18.91 11.89 4 438476 7843 110142976
Pseudocellulitis 18.87 11.89 15 438465 430 110150389
Brachydactyly 18.87 11.89 7 438473 38 110150781
Non-Hodgkin's lymphoma 18.86 11.89 26 438454 1433 110149386
Upper-airway cough syndrome 18.85 11.89 21 438459 15836 110134983
Exophthalmos 18.84 11.89 33 438447 2240 110148579
T-cell prolymphocytic leukaemia 18.84 11.89 8 438472 65 110150754
Parvovirus infection 18.83 11.89 21 438459 930 110149889
Chemotherapeutic drug level increased 18.79 11.89 16 438464 506 110150313
Blood urea increased 18.76 11.89 134 438346 54823 110095996
Cytotoxic oedema 18.75 11.89 15 438465 434 110150385
Stevens-Johnson syndrome 18.74 11.89 109 438371 46792 110104027
Precursor T-lymphoblastic lymphoma/leukaemia recurrent 18.72 11.89 6 438474 19 110150800
Rubulavirus test positive 18.72 11.89 6 438474 19 110150800
Psychomotor retardation 18.72 11.89 4 438476 7788 110143031
Chromaturia 18.71 11.89 57 438423 29303 110121516
Aortic arteriosclerosis 18.70 11.89 10 438470 10928 110139891
Perineal infection 18.66 11.89 20 438460 847 110149972
Endometrial adenocarcinoma 18.62 11.89 24 438456 1239 110149580
Diaphragm muscle weakness 18.52 11.89 11 438469 193 110150626
Hyperproteinaemia 18.52 11.89 13 438467 307 110150512
Mesenteric abscess 18.51 11.89 10 438470 145 110150674
Herpes zoster cutaneous disseminated 18.50 11.89 16 438464 517 110150302
Micturition urgency 18.48 11.89 30 438450 19290 110131529
Blood HIV RNA increased 18.44 11.89 32 438448 2156 110148663
Hepatic amoebiasis 18.37 11.89 9 438471 105 110150714
Viral cardiomyopathy 18.29 11.89 7 438473 42 110150777
Peripheral blood stem cell apheresis 18.27 11.89 10 438470 149 110150670
Normal newborn 18.26 11.89 37 438443 21859 110128960
Growth retardation 18.26 11.89 35 438445 2547 110148272
Acanthamoeba infection 18.26 11.89 17 438463 606 110150213
Carotid intima-media thickness increased 18.23 11.89 9 438471 107 110150712
Bone marrow leukaemic cell infiltration 18.23 11.89 9 438471 107 110150712
Ovarian cyst 18.20 11.89 17 438463 13913 110136906
Muscle tightness 18.16 11.89 19 438461 14743 110136076
Acquired macroglossia 18.15 11.89 12 438468 256 110150563
Neurofibrosarcoma 18.15 11.89 12 438468 256 110150563
Marginal zone lymphoma recurrent 18.15 11.89 7 438473 43 110150776
Chills 18.14 11.89 927 437553 189653 109961166
Adenoviral upper respiratory infection 18.14 11.89 4 438476 0 110150819
Gastrointestinal inflammation 18.07 11.89 80 438400 9389 110141430
Diverticulitis 18.03 11.89 131 438349 53391 110097428
Light chain analysis increased 18 11.89 33 438447 2322 110148497
Meningitis bacterial 17.99 11.89 39 438441 3100 110147719
Cardiac ventricular thrombosis 17.92 11.89 39 438441 3108 110147711
Intracranial hypotension 17.92 11.89 17 438463 621 110150198
Peritonitis 17.88 11.89 203 438277 32404 110118415
Cholangiocarcinoma 17.87 11.89 37 438443 2848 110147971
Endocarditis 17.77 11.89 102 438378 13269 110137550
Lipidosis 17.75 11.89 7 438473 46 110150773
Gliosis 17.75 11.89 18 438462 714 110150105
Coronary artery stenosis 17.73 11.89 17 438463 13741 110137078
IgA nephropathy 17.71 11.89 39 438441 3134 110147685
Proctalgia 17.66 11.89 101 438379 13121 110137698
Ovarian stromal hyperplasia 17.64 11.89 6 438474 24 110150795
Helicobacter sepsis 17.64 11.89 6 438474 24 110150795
Penicillium infection 17.63 11.89 17 438463 634 110150185
Haematocolpos 17.62 11.89 7 438473 47 110150772
Tachypnoea 17.60 11.89 236 438244 39159 110111660
Epidermal necrosis 17.60 11.89 38 438442 3012 110147807
Peripheral vascular disorder 17.60 11.89 6 438474 8570 110142249
Pharyngitis streptococcal 17.59 11.89 16 438464 13261 110137558
Aplasia pure red cell 17.58 11.89 80 438400 9498 110141321
Lymphocytic infiltration 17.57 11.89 30 438450 1995 110148824
Sinus bradycardia 17.56 11.89 59 438421 29424 110121395
Fungal test positive 17.54 11.89 22 438458 1105 110149714
Granulicatella infection 17.54 11.89 10 438470 162 110150657
Ischaemic cardiomyopathy 17.52 11.89 5 438475 8006 110142813
Streptococcal sepsis 17.51 11.89 52 438428 5020 110145799
Histoplasmosis disseminated 17.48 11.89 44 438436 3855 110146964
Non-Hodgkin's lymphoma recurrent 17.45 11.89 6 438474 25 110150794
Colitis erosive 17.44 11.89 12 438468 274 110150545
Iron deficiency 17.39 11.89 29 438451 18447 110132372
Intervertebral disc degeneration 17.38 11.89 28 438452 18057 110132762
Lymphatic duct injury 17.38 11.89 7 438473 49 110150770
Synovial cyst 17.38 11.89 12 438468 11418 110139401
Wrong product administered 17.35 11.89 11 438469 10949 110139870
Polyneuropathy in malignant disease 17.31 11.89 15 438465 486 110150333
Cardiac cirrhosis 17.29 11.89 12 438468 278 110150541
Parkinsonism 17.25 11.89 39 438441 22148 110128671
Tooth hypoplasia 17.24 11.89 13 438467 344 110150475
Miller Fisher syndrome 17.24 11.89 13 438467 344 110150475
Decreased appetite 17.23 11.89 1638 436842 474208 109676611
Gestational trophoblastic tumour 17.22 11.89 5 438475 10 110150809
Mediastinal mass 17.21 11.89 18 438462 741 110150078
Pneumococcal infection 17.19 11.89 28 438452 1791 110149028
Intracranial pressure increased 17.16 11.89 85 438395 10450 110140369
Skin lesion 17.14 11.89 294 438186 51337 110099482
Karyotype analysis abnormal 17.14 11.89 7 438473 51 110150768
Pneumonia influenzal 17.13 11.89 43 438437 3762 110147057
Product preparation error 17.11 11.89 11 438469 10868 110139951
Corticobasal degeneration 17.08 11.89 6 438474 27 110150792
Precursor B-lymphoblastic lymphoma recurrent 17.08 11.89 6 438474 27 110150792
Necrotising retinitis 17.07 11.89 26 438454 1570 110149249
Vitamin D decreased 17.06 11.89 14 438466 12201 110138618
Ventricular fibrillation 17.05 11.89 95 438385 41218 110109601
Disseminated tuberculosis 17.05 11.89 52 438428 5094 110145725
Keratopathy 17.05 11.89 24 438456 1349 110149470
Basal ganglion degeneration 17.01 11.89 14 438466 422 110150397
Extravasation blood 17.01 11.89 15 438465 498 110150321
Stomatitis necrotising 17.00 11.89 11 438469 226 110150593
CSF protein increased 16.96 11.89 25 438455 1466 110149353
Multiple-drug resistance 16.96 11.89 100 438380 13135 110137684
Neuroborreliosis 16.96 11.89 10 438470 173 110150646
Mycobacterial infection 16.91 11.89 47 438433 4370 110146449
Subacute combined cord degeneration 16.89 11.89 13 438467 355 110150464
Pneumonitis chemical 16.83 11.89 17 438463 671 110150148
Tumour pseudoprogression 16.83 11.89 26 438454 1590 110149229
Cardiopulmonary failure 16.80 11.89 69 438411 7834 110142985
Photosensitivity reaction 16.80 11.89 49 438431 25540 110125279
General symptom 16.79 11.89 7 438473 8839 110141980
Polymyositis 16.79 11.89 42 438438 3666 110147153
Expired product administered 16.76 11.89 6 438474 8314 110142505
Parotitis 16.75 11.89 38 438442 3115 110147704
B-cell lymphoma stage IV 16.74 11.89 8 438472 88 110150731
Mycoplasma infection 16.72 11.89 24 438456 1374 110149445
Dyspnoea exertional 16.69 11.89 301 438179 103759 110047060
Sarcoma metastatic 16.67 11.89 8 438472 89 110150730
Xanthogranuloma 16.67 11.89 8 438472 89 110150730
Ultrasound foetal abnormal 16.67 11.89 8 438472 89 110150730
Skin cancer 16.65 11.89 28 438452 17756 110133063
Hyperlactacidaemia 16.65 11.89 6 438474 8280 110142539
Cellulitis staphylococcal 16.65 11.89 24 438456 1379 110149440
Ageusia 16.55 11.89 33 438447 19612 110131207
Lupus myocarditis 16.51 11.89 8 438472 91 110150728
Natural killer cell count decreased 16.45 11.89 9 438471 134 110150685
Paranasal sinus mucosal hypertrophy 16.43 11.89 8 438472 92 110150727
Eye infection 16.42 11.89 20 438460 14498 110136321
Hydronephrosis 16.41 11.89 139 438341 20526 110130293
Disorder of orbit 16.39 11.89 9 438471 135 110150684
Pulmonary sarcoidosis 16.38 11.89 27 438453 1745 110149074
Tongue fungal infection 16.37 11.89 10 438470 185 110150634
Pneumonia necrotising 16.34 11.89 27 438453 1748 110149071
Pancreatic carcinoma 16.29 11.89 21 438459 14851 110135968
Peliosis hepatis 16.28 11.89 10 438470 187 110150632
Cytomegalovirus hepatitis 16.24 11.89 19 438461 887 110149932
Anorectal cellulitis 16.21 11.89 8 438472 95 110150724
Inflammatory pseudotumour 16.21 11.89 8 438472 95 110150724
Carotid artery thrombosis 16.20 11.89 9 438471 9629 110141190
Pharyngeal oedema 16.20 11.89 25 438455 16403 110134416
Overweight 16.20 11.89 3 438477 6461 110144358
Adenoviral encephalitis 16.17 11.89 7 438473 60 110150759
Palatal ulcer 16.11 11.89 11 438469 248 110150571
Spinal cord compression 16.11 11.89 66 438414 7486 110143333
Splenic lesion 16.11 11.89 16 438464 619 110150200
Blood thyroid stimulating hormone increased 16.09 11.89 15 438465 12286 110138533
Ventricular tachycardia 16.08 11.89 124 438356 49885 110100934
Umbilical hernia 16.08 11.89 4 438476 7018 110143801
Blood creatinine increased 16.08 11.89 578 437902 182311 109968508
Dysgraphia 16.02 11.89 48 438432 4657 110146162
Eastern Cooperative Oncology Group performance status worsened 16.01 11.89 36 438444 2933 110147886
Enterovesical fistula 16.01 11.89 24 438456 1429 110149390
Lung abscess 16.01 11.89 50 438430 4962 110145857
Systolic dysfunction 15.95 11.89 46 438434 4369 110146450
Blood cholinesterase decreased 15.94 11.89 14 438466 462 110150357
Benign prostatic hyperplasia 15.91 11.89 30 438450 18204 110132615
Breast angiosarcoma 15.91 11.89 4 438476 3 110150816
Burkholderia pseudomallei infection 15.88 11.89 9 438471 144 110150675
Joint neoplasm 15.87 11.89 7 438473 63 110150756
Natural killer-cell lymphoblastic lymphoma 15.87 11.89 7 438473 63 110150756
Premature ageing 15.85 11.89 8 438472 100 110150719
Aortic stenosis 15.85 11.89 17 438463 13042 110137777
Subcutaneous emphysema 15.85 11.89 33 438447 2551 110148268
Tenosynovitis 15.84 11.89 25 438455 16258 110134561
Complication associated with device 15.84 11.89 35 438445 20038 110130781
Transplant rejection 15.84 11.89 158 438322 24409 110126410
Cerebellar syndrome 15.83 11.89 58 438422 6244 110144575
Microvascular coronary artery disease 15.82 11.89 13 438467 391 110150428
Depressed level of consciousness 15.80 11.89 332 438148 111946 110038873
Polyserositis 15.80 11.89 20 438460 1014 110149805
Productive cough 15.80 11.89 339 438141 113966 110036853
Paratracheal lymphadenopathy 15.78 11.89 10 438470 198 110150621
POEMS syndrome 15.78 11.89 7 438473 64 110150755
Vitamin D deficiency 15.77 11.89 31 438449 18521 110132298
Fungal endocarditis 15.77 11.89 18 438462 818 110150001
Abdominal lymphadenopathy 15.76 11.89 27 438453 1801 110149018
Actinomycotic sepsis 15.69 11.89 10 438470 200 110150619
Enterocolitis haemorrhagic 15.67 11.89 33 438447 2571 110148248
Eosinophilic myocarditis 15.66 11.89 29 438451 2056 110148763
Femoral neck fracture 15.65 11.89 16 438464 12551 110138268
Proteus test positive 15.65 11.89 17 438463 731 110150088
Listeria encephalitis 15.65 11.89 12 438468 326 110150493
CD4/CD8 ratio decreased 15.59 11.89 7 438473 66 110150753
Pleural neoplasm 15.54 11.89 13 438467 401 110150418
Hepatitis B e antigen positive 15.54 11.89 6 438474 37 110150782
Bacterial translocation 15.53 11.89 24 438456 1468 110149351
Infusion site swelling 15.51 11.89 10 438470 9867 110140952
Liver scan abnormal 15.50 11.89 7 438473 67 110150752
Cardiac arrest 15.50 11.89 630 437850 196123 109954696
Salmonellosis 15.48 11.89 30 438450 2201 110148618
Respiratory rate decreased 15.48 11.89 3 438477 6255 110144564
Radiation necrosis 15.46 11.89 18 438462 836 110149983
Facial pain 15.46 11.89 23 438457 15316 110135503
Depressive symptom 15.43 11.89 7 438473 8407 110142412
Double hit lymphoma 15.40 11.89 6 438474 38 110150781
Autologous bone marrow transplantation therapy 15.40 11.89 6 438474 38 110150781
Intussusception 15.39 11.89 25 438455 1596 110149223
Retinal fovea disorder 15.38 11.89 4 438476 4 110150815
Sinus tachycardia 15.37 11.89 255 438225 44238 110106581
Pseudomembranous colitis 15.37 11.89 58 438422 6333 110144486
Vaginal infection 15.34 11.89 4 438476 6800 110144019
Post-depletion B-cell recovery 15.33 11.89 5 438475 17 110150802
Hypogonadism 15.32 11.89 28 438452 1966 110148853
Antithrombin III deficiency 15.25 11.89 9 438471 156 110150663
Perineal ulceration 15.24 11.89 8 438472 109 110150710
Glomerulonephritis membranous 15.22 11.89 28 438452 1975 110148844
Conjunctival scar 15.21 11.89 12 438468 340 110150479
Device pacing issue 15.20 11.89 9 438471 157 110150662
Haemophilus infection 15.16 11.89 34 438446 2766 110148053
Carotidynia 15.10 11.89 9 438471 159 110150660
Eosinophilic cystitis 15.10 11.89 9 438471 159 110150660
Anti-glomerular basement membrane disease 15.10 11.89 9 438471 159 110150660
Meniscus injury 15.07 11.89 6 438474 7787 110143032
Anaplastic large-cell lymphoma 15.06 11.89 10 438470 215 110150604
Agnosia 15.06 11.89 11 438469 277 110150542
Major depression 15.05 11.89 12 438468 10609 110140210
Hyperuricaemia 15.04 11.89 104 438376 14427 110136392
Breath sounds abnormal 15.02 11.89 51 438429 25353 110125466
Transient hypogammaglobulinaemia of infancy 15.02 11.89 6 438474 41 110150778
Unwanted pregnancy 15.02 11.89 6 438474 41 110150778
Mucocutaneous haemorrhage 14.96 11.89 11 438469 280 110150539
Retinopathy 14.91 11.89 45 438435 4384 110146435
Arthropod bite 14.91 11.89 10 438470 9661 110141158
Lymph node fibrosis 14.90 11.89 5 438475 19 110150800
Post lumbar puncture syndrome 14.86 11.89 20 438460 1077 110149742
Dermatofibrosarcoma protuberans 14.81 11.89 7 438473 75 110150744
Malassezia infection 14.81 11.89 7 438473 75 110150744
Eye inflammation 14.80 11.89 9 438471 9162 110141657
Antinuclear antibody positive 14.79 11.89 9 438471 9159 110141660
Renal hydrocele 14.78 11.89 6 438474 43 110150776
Mastoid disorder 14.73 11.89 7 438473 76 110150743
Erysipelas 14.72 11.89 96 438384 13062 110137757
Clonal haematopoiesis 14.71 11.89 9 438471 167 110150652
Infusion site eschar 14.70 11.89 5 438475 20 110150799
Cerebral salt-wasting syndrome 14.69 11.89 11 438469 288 110150531
Aortic wall hypertrophy 14.66 11.89 6 438474 44 110150775
Respiratory acidosis 14.65 11.89 20 438460 13806 110137013
Citrobacter sepsis 14.65 11.89 7 438473 77 110150742
Burkitt's lymphoma 14.63 11.89 8 438472 119 110150700
Juvenile idiopathic arthritis 14.60 11.89 3 438477 6004 110144815
Therapeutic response decreased 14.60 11.89 493 437987 96006 110054813
Drug eruption 14.59 11.89 139 438341 53520 110097299
Blood pressure inadequately controlled 14.56 11.89 6 438474 7627 110143192
Pyelocaliectasis 14.55 11.89 20 438460 1099 110149720
Metastases to breast 14.55 11.89 12 438468 363 110150456
Gingival pain 14.53 11.89 25 438455 15711 110135108
Atypical teratoid/rhabdoid tumour of CNS 14.51 11.89 5 438475 21 110150798
Pneumonia measles 14.51 11.89 5 438475 21 110150798
Reproductive toxicity 14.50 11.89 4 438476 6 110150813
Blastic plasmacytoid dendritic cell neoplasia 14.49 11.89 7 438473 79 110150740
Bordetella infection 14.47 11.89 10 438470 230 110150589
Urethral obstruction 14.46 11.89 11 438469 295 110150524
Chronic cutaneous lupus erythematosus 14.46 11.89 19 438461 1000 110149819
Basophilia 14.43 11.89 6 438474 46 110150773
Gastrointestinal candidiasis 14.43 11.89 14 438466 526 110150293
Transfusion reaction 14.43 11.89 28 438452 2057 110148762
Metastases to uterus 14.42 11.89 7 438473 80 110150739
Fungal skin infection 14.41 11.89 62 438418 7187 110143632
Neutrophil morphology abnormal 14.40 11.89 8 438472 123 110150696
Pruritus genital 14.39 11.89 4 438476 6518 110144301
Psychomotor skills impaired 14.37 11.89 5 438475 7053 110143766
Bile duct necrosis 14.34 11.89 7 438473 81 110150738
Follicular mucinosis 14.33 11.89 5 438475 22 110150797
Biliary abscess 14.32 11.89 6 438474 47 110150772
Infusion site vesicles 14.29 11.89 15 438465 620 110150199
Alopecia totalis 14.28 11.89 13 438467 450 110150369
Arteritis infective 14.25 11.89 9 438471 177 110150642
Pelvic fluid collection 14.25 11.89 19 438461 1014 110149805
Pharyngeal swelling 14.23 11.89 16 438464 12016 110138803
Parasitic gastroenteritis 14.21 11.89 10 438470 237 110150582
Heavy menstrual bleeding 14.21 11.89 27 438453 16338 110134481
Acral lentiginous melanoma 14.21 11.89 6 438474 48 110150771
Metastases to stomach 14.21 11.89 11 438469 303 110150516
Stomatococcal infection 14.19 11.89 12 438468 376 110150443
Human rhinovirus test positive 14.19 11.89 21 438459 1236 110149583
Neutrophil toxic granulation present 14.18 11.89 10 438470 238 110150581
Sinus pain 14.16 11.89 3 438477 5876 110144943
Median nerve injury 14.15 11.89 5 438475 23 110150796
Toxic leukoencephalopathy 14.09 11.89 24 438456 1593 110149226
Peripheral coldness 14.08 11.89 33 438447 18507 110132312
Cardiac valve disease 14.06 11.89 4 438476 6417 110144402
Pulse waveform abnormal 14.05 11.89 7 438473 85 110150734
Ankle brachial index decreased 14.05 11.89 7 438473 85 110150734
Paradoxical drug reaction 14.02 11.89 11 438469 9806 110141013
Renal pain 14.02 11.89 11 438469 9806 110141013
Trichodysplasia spinulosa 14.01 11.89 19 438461 1031 110149788
Endocardial fibrosis 14.00 11.89 6 438474 50 110150769
Infectious pleural effusion 14.00 11.89 47 438433 4844 110145975
Chimerism 14.00 11.89 11 438469 310 110150509
Central nervous system neoplasm 13.99 11.89 9 438471 183 110150636
Respiratory disorder 13.94 11.89 199 438281 71183 110079636
Meningitis pneumococcal 13.93 11.89 16 438464 732 110150087
Bone marrow tumour cell infiltration 13.90 11.89 6 438474 51 110150768
Pleural disorder 13.88 11.89 19 438461 1040 110149779
Cheilitis 13.87 11.89 4 438476 6361 110144458
Tongue disorder 13.87 11.89 22 438458 14276 110136543
Splenic necrosis 13.86 11.89 9 438471 186 110150633
Focal segmental glomerulosclerosis 13.84 11.89 42 438438 4103 110146716
Aspiration 13.84 11.89 68 438412 30465 110120354
Haemorrhagic pneumonia 13.82 11.89 9 438471 187 110150632
Aortic valve stenosis 13.82 11.89 4 438476 6346 110144473
Urinary bladder toxicity 13.81 11.89 5 438475 25 110150794
Palisaded neutrophilic granulomatous dermatitis 13.81 11.89 5 438475 25 110150794
Galectin-3 increased 13.81 11.89 5 438475 25 110150794
Restrictive pulmonary disease 13.81 11.89 36 438444 3223 110147596
Product availability issue 13.80 11.89 7 438473 7883 110142936
Groin pain 13.80 11.89 25 438455 15403 110135416
Pulmonary hypoplasia 13.80 11.89 6 438474 52 110150767
Sphingomonas paucimobilis infection 13.79 11.89 8 438472 134 110150685
Cerebral venous thrombosis 13.79 11.89 36 438444 3226 110147593
Cardiac failure congestive 13.78 11.89 475 438005 150525 110000294
Photophobia 13.74 11.89 54 438426 25717 110125102
Gastritis fungal 13.73 11.89 11 438469 319 110150500
Acute hepatic failure 13.72 11.89 212 438268 36256 110114563
Personality change 13.71 11.89 14 438466 10988 110139831
Infusion site necrosis 13.70 11.89 7 438473 90 110150729
Atrioventricular block first degree 13.69 11.89 22 438458 14203 110136616
Meningitis listeria 13.69 11.89 21 438459 1276 110149543
Gamma-glutamyltransferase increased 13.66 11.89 329 438151 60980 110089839
Nasal oedema 13.66 11.89 5 438475 6834 110143985
Wheelchair user 13.66 11.89 7 438473 7835 110142984
Extrasystoles 13.65 11.89 8 438472 8310 110142509
Retinal toxicity 13.64 11.89 24 438456 1635 110149184
Pulmonary sepsis 13.62 11.89 49 438431 5229 110145590
Sinus polyp 13.60 11.89 15 438465 656 110150163
Apheresis 13.60 11.89 3 438477 0 110150819
Precursor B-lymphoblastic lymphoma refractory 13.60 11.89 3 438477 0 110150819
Intercepted product preparation error 13.60 11.89 5 438475 6815 110144004
Eye discharge 13.56 11.89 9 438471 8745 110142074
Hereditary motor and sensory neuropathy 13.54 11.89 8 438472 139 110150680
CSF test abnormal 13.52 11.89 16 438464 756 110150063
Scoliosis 13.50 11.89 9 438471 8724 110142095
Toxocariasis 13.50 11.89 5 438475 27 110150792
Viral skin infection 13.49 11.89 9 438471 195 110150624
Hypodontia 13.46 11.89 4 438476 9 110150810
Skin warm 13.45 11.89 10 438470 9160 110141659
Pulmonary cavitation 13.43 11.89 28 438452 2166 110148653
Gastrointestinal motility disorder 13.43 11.89 6 438474 7270 110143549
Pneumonia parainfluenzae viral 13.42 11.89 15 438465 666 110150153
Fibrosis 13.42 11.89 63 438417 7579 110143240
Cachexia 13.42 11.89 93 438387 12912 110137907
Infusion site streaking 13.39 11.89 14 438466 576 110150243
Formication 13.36 11.89 3 438477 5645 110145174
Arthritis infective 13.31 11.89 13 438467 10416 110140403
Impaired gastric emptying 13.28 11.89 20 438460 13255 110137564
Hospice care 13.26 11.89 18 438462 12455 110138364
Sickle cell anaemia with crisis 13.25 11.89 11 438469 9534 110141285
Cutaneous T-cell lymphoma recurrent 13.24 11.89 7 438473 97 110150722
Metastases to testicle 13.23 11.89 6 438474 58 110150761
Myelofibrosis 13.23 11.89 34 438446 3017 110147802
Hepatitis fulminant 13.20 11.89 68 438412 8492 110142327
Deafness neurosensory 13.19 11.89 74 438406 9545 110141274
Cystitis escherichia 13.16 11.89 16 438464 778 110150041
Mycobacterium abscessus infection 13.16 11.89 24 438456 1682 110149137
Meningeal neoplasm 13.14 11.89 6 438474 59 110150760
Anaesthesia 13.12 11.89 14 438466 590 110150229
Leukonychia 13.11 11.89 7 438473 99 110150720
Parenteral nutrition 13.11 11.89 17 438463 883 110149936
Candida endophthalmitis 13.10 11.89 9 438471 205 110150614
Respiratory rate increased 13.10 11.89 53 438427 25030 110125789
Tenderness 13.09 11.89 66 438414 29371 110121448
Endothelial dysfunction 13.08 11.89 11 438469 342 110150477
Lymph node haemorrhage 13.06 11.89 5 438475 30 110150789
Lung neoplasm 13.04 11.89 65 438415 8011 110142808
Fanconi syndrome 13.04 11.89 37 438443 3482 110147337
Alternaria infection 13.03 11.89 18 438462 994 110149825
Ocular lymphoma 12.99 11.89 9 438471 208 110150611
Portal vein embolism 12.99 11.89 7 438473 101 110150718
Pleocytosis 12.98 11.89 24 438456 1700 110149119
Adrenal mass 12.95 11.89 23 438457 1579 110149240
Prostatic abscess 12.94 11.89 14 438466 599 110150220
Oral bacterial infection 12.93 11.89 7 438473 102 110150717
Cytokine abnormal 12.89 11.89 4 438476 11 110150808
Cancer in remission 12.89 11.89 6 438474 62 110150757
Troponin T increased 12.88 11.89 42 438438 4264 110146555
Overgrowth fungal 12.87 11.89 8 438472 153 110150666
Anogenital warts 12.85 11.89 19 438461 1117 110149702
Light chain disease 12.81 11.89 10 438470 279 110150540
Pseudomonas aeruginosa meningitis 12.81 11.89 7 438473 104 110150715
Lymphoplasmacytoid lymphoma/immunocytoma 12.80 11.89 6 438474 63 110150756
Monoclonal immunoglobulin increased 12.79 11.89 14 438466 607 110150212
Scleroderma renal crisis 12.77 11.89 17 438463 906 110149913
Mycobacterium haemophilum infection 12.76 11.89 15 438465 704 110150115
Bulbar palsy 12.76 11.89 11 438469 354 110150465
Purpura fulminans 12.76 11.89 11 438469 354 110150465
Biopsy lymph gland 12.75 11.89 7 438473 105 110150714
Hodgkin's disease 12.75 11.89 16 438464 804 110150015
Primary adrenal insufficiency 12.74 11.89 14 438466 610 110150209
Gingival hypertrophy 12.74 11.89 42 438438 4289 110146530
Platelet count abnormal 12.69 11.89 54 438426 6228 110144591
Hepatitis D 12.69 11.89 7 438473 106 110150713
Abdominal pain lower 12.68 11.89 91 438389 37192 110113627
Gastroenteritis cryptosporidial 12.65 11.89 11 438469 358 110150461
Hyponatraemic coma 12.64 11.89 6 438474 65 110150754
Adenovirus test positive 12.63 11.89 7 438473 107 110150712
Gastrointestinal protozoal infection 12.63 11.89 7 438473 107 110150712
Papule 12.62 11.89 76 438404 10057 110140762
Procedural haemorrhage 12.61 11.89 3 438477 5424 110145395
Gout 12.56 11.89 89 438391 36477 110114342
Joint tuberculosis 12.55 11.89 9 438471 220 110150599
Glomerulosclerosis 12.54 11.89 20 438460 1257 110149562
Campylobacter colitis 12.52 11.89 7 438473 109 110150710
Blood phosphorus increased 12.48 11.89 29 438451 16311 110134508
Urinary bladder rupture 12.47 11.89 8 438472 162 110150657
Pulmonary calcification 12.45 11.89 13 438467 534 110150285
Tendon rupture 12.43 11.89 23 438457 14055 110136764
Hyponatraemic seizure 12.43 11.89 15 438465 724 110150095
Social avoidant behaviour 12.41 11.89 3 438477 5366 110145453
Blood glucose abnormal 12.41 11.89 20 438460 12896 110137923
Hepatitis B core antibody 12.40 11.89 4 438476 13 110150806
Measles post vaccine 12.40 11.89 4 438476 13 110150806
Microgenia 12.40 11.89 4 438476 13 110150806
Kidney fibrosis 12.39 11.89 42 438438 4350 110146469
Jaw operation 12.38 11.89 16 438464 828 110149991
Palatal disorder 12.37 11.89 13 438467 538 110150281
Light chain analysis abnormal 12.31 11.89 9 438471 227 110150592
Tearfulness 12.30 11.89 7 438473 7388 110143431
Myofascitis 12.29 11.89 5 438475 36 110150783
Cataract operation 12.27 11.89 4 438476 5879 110144940
Breast cancer female 12.27 11.89 19 438461 12449 110138370
Petechiae 12.27 11.89 144 438336 23173 110127646
Vulvovaginal inflammation 12.26 11.89 15 438465 734 110150085
Tracheal stenosis 12.25 11.89 14 438466 637 110150182
Mycobacterium avium complex infection 12.25 11.89 51 438429 5826 110144993
Cholestatic liver injury 12.24 11.89 7 438473 7369 110143450
Hypoglossal nerve paresis 12.19 11.89 7 438473 115 110150704
Food protein-induced enterocolitis syndrome 12.18 11.89 5 438475 37 110150782
Conus medullaris syndrome 12.18 11.89 6 438474 71 110150748
Mouth swelling 12.17 11.89 7 438473 7347 110143472
Diarrhoea infectious 12.16 11.89 25 438455 1915 110148904
Drug clearance decreased 12.15 11.89 40 438440 4082 110146737
Therapy change 12.15 11.89 13 438467 9984 110140835
Electrocardiogram T wave biphasic 12.14 11.89 9 438471 232 110150587
Meningitis staphylococcal 12.14 11.89 9 438471 232 110150587
Pneumococcal sepsis 12.13 11.89 27 438453 2185 110148634
Acquired haemophilia 12.12 11.89 30 438450 2601 110148218
Catarrh 12.11 11.89 7 438473 7328 110143491
Histiocytosis 12.10 11.89 6 438474 72 110150747
Scar 12.07 11.89 31 438449 16850 110133969
Colorectal cancer 12.05 11.89 11 438469 9103 110141716
Meningoencephalitis amoebic 12.04 11.89 9 438471 235 110150584
Bladder perforation 12.03 11.89 11 438469 383 110150436
Hypocalcaemia 12.02 11.89 342 438138 65024 110085795
Pulmonary infarction 11.98 11.89 40 438440 4111 110146708
Periorbital cellulitis 11.98 11.89 18 438462 1074 110149745
Metastases to tonsils 11.96 11.89 4 438476 15 110150804
Circumstance or information capable of leading to medication error 11.95 11.89 3 438477 5230 110145589
Apraxia 11.95 11.89 36 438444 3504 110147315
Cholecystitis chronic 11.94 11.89 12 438468 9488 110141331
Pneumococcal bacteraemia 11.91 11.89 9 438471 239 110150580
Gastrointestinal obstruction 11.90 11.89 27 438453 2213 110148606

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01AA01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ALKYLATING AGENTS
Nitrogen mustard analogues
MeSH PA D000477 Alkylating Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009153 Mutagens
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018906 Antineoplastic Agents, Alkylating
MeSH PA D019653 Myeloablative Agonists
CHEBI has role CHEBI:22333 alkylating agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:50903 carcinogenic agent
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:50249 anticoagulant
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:76595 nephroprotective agent
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:88188 drug allergen
CHEBI has role CHEBI:231911 renoprotective agent
CHEBI has role CHEBI:233423 antifibrotic agent

Related Drugs by ATC class:

L01AA Nitrogen mustard analogues 8 drugs
bendamustinechlorambucilifosfamidemechlorethaminemelphalanmelphalan flufenamideprednimustinetrofosfamide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Systemic AL amyloidosis indication 23132008
Acute lymphoid leukemia, disease indication 91857003 DOID:9952
Chronic lymphoid leukemia, disease indication 92814006
Chronic myeloid leukemia indication 92818009 DOID:8552
Leukemia, disease indication 93143009 DOID:1240
Histiocytic lymphoma indication 109988003
Multiple myeloma indication 109989006 DOID:9538
Hodgkin's disease indication 118599009
Malignant lymphoma indication 118600007 DOID:0060058
Burkitt's lymphoma indication 118617000
Mycosis fungoides indication 118618005
Mixedcell type lymphoma indication 188676008
Carcinoma of breast indication 254838004 DOID:3459
Acute myelogenous leukemia indication 359640008
Adenocarcinoma of the ovary indication 363443007 DOID:2394
Retinoblastoma indication 370967009 DOID:768
Acute monocytic leukemia indication 413441006
Neuroblastoma indication 432328008 DOID:769
Treatment prior to tumor-specific T-cell infusion therapy indication
Blood dyscrasias contraindication 34093004
Urinary outflow obstruction contraindication 252028009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.39 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Cytochrome P450 3A4 Enzyme IC50 5.68 WOMBAT-PK

External reference:

IDSource
4018114 VUID
N0000146452 NUI
D00287 KEGG_DRUG
3002 RXNORM
C0010583 UMLSCUI
CHEBI:4026 CHEBI
CHEMBL1200796 ChEMBL_ID
DB00531 DRUGBANK_ID
D003520 MESH_DESCRIPTOR_UI
2907 PUBCHEM_CID
7154 IUPHAR_LIGAND_ID
8N3DW7272P UNII
31952 MMSL
4519 MMSL
d00036 MMSL
002631 NDDF
387420009 SNOMEDCT_US
74470007 SNOMEDCT_US
6055-19-2 SECONDARY_CAS_RN
4018114 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0054-0382 CAPSULE 25 mg ORAL NDA 26 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0054-0383 CAPSULE 50 mg ORAL NDA 26 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0338-9777 INJECTION 200 mg INTRAVENOUS NDA 28 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0338-9779 INJECTION 200 mg INTRAVENOUS NDA 28 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3233 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3244 INJECTION, POWDER, FOR SOLUTION 1 g ORAL ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3255 INJECTION, POWDER, FOR SOLUTION 2 g ORAL ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3528 INJECTION, SOLUTION, CONCENTRATE 500 mg INTRAVENOUS NDA 27 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3529 INJECTION, SOLUTION, CONCENTRATE 1000 mg INTRAVENOUS NDA 27 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3530 INJECTION, SOLUTION, CONCENTRATE 2000 mg INTRAVENOUS NDA 27 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-935 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-935 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-936 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-936 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-937 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-937 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-938 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-938 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-939 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-939 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-942 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-942 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-943 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-943 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-944 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-944 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-945 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-945 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-955 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-956 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections