cyclophosphamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
alkylating agents of the cyclophosphamide group 758 50-18-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cyclophosphamide
  • cyclophosphamid
  • cyclophosphamidum
  • cyclophosphan
  • cyclophosphane
  • cytophosphan
  • mitoxan
  • cyclophosphamide hydrate
  • endoxan
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
  • Molecular weight: 261.08
  • Formula: C7H15Cl2N2O2P
  • CLOGP: 0.80
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 41.57
  • ALOGS: -1.24
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 40 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 6.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 19.15 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 74 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.73 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.87 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 8 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 16, 1959 FDA BAXTER HLTHCARE
March 26, 2019 PMDA SHIONOGI & Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 6396.73 11.21 4085 179814 101460 56006708
Neutropenia 3143.85 11.21 3185 180714 154982 55953186
Myelosuppression 1502.54 11.21 849 183050 16606 56091562
Bone marrow failure 1395.65 11.21 966 182933 27320 56080848
Acute myeloid leukaemia 1270.71 11.21 754 183145 16218 56091950
Agranulocytosis 1041.21 11.21 741 183158 21918 56086250
Cytokine release syndrome 1006.77 11.21 555 183344 10320 56097848
Mucosal inflammation 975.42 11.21 931 182968 41879 56066289
Myelodysplastic syndrome 901.26 11.21 599 183300 15807 56092361
Pancytopenia 895.92 11.21 1268 182631 87447 56020721
Leukopenia 895.81 11.21 1131 182768 69809 56038359
Disease recurrence 889.26 11.21 688 183211 23172 56084996
Rheumatoid arthritis 883.48 11.21 107 183792 382497 55725671
Disease progression 871.35 11.21 1370 182529 103803 56004365
Cytomegalovirus infection 861.20 11.21 620 183279 18676 56089492
Haematotoxicity 851.55 11.21 455 183444 7928 56100240
Product use in unapproved indication 839.17 11.21 1585 182314 139237 55968931
Thrombocytopenia 815.08 11.21 1536 182363 134688 55973480
Second primary malignancy 812.15 11.21 423 183476 6979 56101189
Neutrophil count decreased 702.55 11.21 840 183059 48982 56059186
White blood cell count decreased 697.62 11.21 1375 182524 124615 55983553
Pyrexia 683.20 11.21 2939 180960 415834 55692334
Pain 678.17 11.21 703 183196 662481 55445687
Cardiotoxicity 676.83 11.21 379 183520 7271 56100897
Acute graft versus host disease 628.77 11.21 296 183603 3879 56104289
Pneumocystis jirovecii pneumonia 609.64 11.21 464 183435 15237 56092931
Malignant neoplasm progression 594.47 11.21 948 182951 72639 56035529
Ejection fraction decreased 592.99 11.21 503 183396 19338 56088830
Diffuse large B-cell lymphoma recurrent 562.61 11.21 213 183686 1544 56106624
Cystitis haemorrhagic 558.88 11.21 268 183631 3669 56104499
Joint swelling 548.64 11.21 136 183763 289664 55818504
Abdominal discomfort 540.91 11.21 122 183777 277152 55831016
Sepsis 501.60 11.21 1284 182615 138556 55969612
Neurotoxicity 493.80 11.21 411 183488 15384 56092784
Pemphigus 490.88 11.21 4 183895 157208 55950960
Febrile bone marrow aplasia 486.60 11.21 290 183609 6282 56101886
Progressive multifocal leukoencephalopathy 484.05 11.21 363 183536 11650 56096518
Fall 483.08 11.21 285 183614 357225 55750943
Synovitis 482.07 11.21 9 183890 161296 55946872
Septic shock 468.45 11.21 767 183132 60068 56048100
Venoocclusive liver disease 466.03 11.21 246 183653 4175 56103993
Graft versus host disease 460.28 11.21 283 183616 6498 56101670
Contraindicated product administered 455.16 11.21 42 183857 186244 55921924
Arthralgia 454.29 11.21 585 183314 501084 55607084
Posterior reversible encephalopathy syndrome 449.23 11.21 391 183508 15569 56092599
Premature menopause 446.61 11.21 147 183752 661 56107507
Metastases to bone 443.60 11.21 424 183475 19084 56089084
Glossodynia 442.00 11.21 12 183887 152446 55955722
Hypogammaglobulinaemia 440.81 11.21 270 183629 6156 56102012
Neoplasm progression 436.80 11.21 531 183368 31485 56076683
Chronic graft versus host disease 433.11 11.21 212 183687 3044 56105124
Product dose omission issue 432.95 11.21 74 183825 204679 55903489
Cytopenia 431.88 11.21 312 183587 9443 56098725
Neutropenic sepsis 427.38 11.21 372 183527 14813 56093355
Cardiomyopathy 427.07 11.21 383 183516 15875 56092293
Swelling 417.40 11.21 132 183767 239639 55868529
Arthropathy 407.05 11.21 80 183819 200195 55907973
Diffuse large B-cell lymphoma 399.39 11.21 262 183637 6754 56101414
Completed suicide 382.56 11.21 12 183887 133821 55974347
Off label use 369.54 11.21 3085 180814 553095 55555073
Multiple organ dysfunction syndrome 368.54 11.21 637 183262 52133 56056035
Acute graft versus host disease in skin 365.65 11.21 188 183711 3014 56105154
Haemophagocytic lymphohistiocytosis 365.23 11.21 280 183619 9292 56098876
Wound 362.39 11.21 23 183876 138781 55969387
Pruritus 358.34 11.21 305 183594 316318 55791850
Nasopharyngitis 353.14 11.21 140 183759 220819 55887349
Therapeutic product effect decreased 352.15 11.21 64 183835 169388 55938780
Peripheral swelling 349.32 11.21 165 183734 234561 55873607
Therapy partial responder 344.64 11.21 249 183650 7536 56100632
Systemic lupus erythematosus 339.54 11.21 85 183814 179993 55928175
Weight increased 339.47 11.21 163 183736 229540 55878628
Tumour lysis syndrome 327.20 11.21 243 183656 7680 56100488
Metastases to liver 324.09 11.21 376 183523 21210 56086958
Drug hypersensitivity 323.87 11.21 255 183644 274950 55833218
Post transplant lymphoproliferative disorder 319.68 11.21 196 183703 4476 56103692
Respiratory failure 315.17 11.21 848 183051 94214 56013954
Hepatitis B reactivation 313.98 11.21 155 183744 2269 56105899
Plasma cell myeloma 313.90 11.21 554 183345 46092 56062076
Neuropathy peripheral 309.67 11.21 886 183013 102007 56006161
Epstein-Barr virus infection 306.20 11.21 228 183671 7235 56100933
Left ventricular dysfunction 298.00 11.21 265 183634 10858 56097310
Acute lymphocytic leukaemia recurrent 297.88 11.21 147 183752 2150 56106018
Palmar-plantar erythrodysaesthesia syndrome 294.84 11.21 354 183545 20711 56087457
Hepatitis B 292.19 11.21 169 183730 3455 56104713
Rash 286.41 11.21 754 183145 492293 55615875
Platelet count decreased 282.15 11.21 876 183023 105507 56002661
Headache 281.91 11.21 914 182985 558130 55550038
Cardiac failure 276.82 11.21 737 183162 81356 56026812
Injection site pain 274.04 11.21 31 183868 117087 55991081
Anaemia 273.57 11.21 1649 182250 265862 55842306
Graft versus host disease in skin 261.11 11.21 142 183757 2565 56105603
Musculoskeletal stiffness 260.63 11.21 92 183807 155915 55952253
Ovarian failure 256.96 11.21 109 183790 1096 56107072
Aplasia 256.59 11.21 161 183738 3835 56104333
Bronchopulmonary aspergillosis 256.12 11.21 214 183685 8050 56100118
Acute promyelocytic leukaemia 248.55 11.21 99 183800 835 56107333
Metastases to lung 248.19 11.21 245 183654 11473 56096695
Sinusitis 243.98 11.21 174 183725 197407 55910761
Anxiety 241.31 11.21 168 183731 193004 55915164
Pleural effusion 240.77 11.21 719 183180 84761 56023407
Bone pain 239.91 11.21 516 183383 49669 56058499
Interstitial lung disease 239.47 11.21 557 183342 56506 56051662
Pain in extremity 238.70 11.21 377 183522 297054 55811114
Dizziness 236.32 11.21 552 183347 375588 55732580
Immune effector cell-associated neurotoxicity syndrome 235.97 11.21 112 183787 1496 56106672
Thrombotic microangiopathy 235.94 11.21 216 183683 9195 56098973
Cytomegalovirus infection reactivation 234.73 11.21 140 183759 3036 56105132
Breast cancer metastatic 229.77 11.21 268 183631 15201 56092967
Discomfort 229.36 11.21 88 183811 141673 55966495
Staphylococcal bacteraemia 229.19 11.21 166 183733 5043 56103125
Hepatic enzyme increased 229.11 11.21 138 183761 171246 55936922
Psoriasis 225.99 11.21 21 183878 92671 56015497
Psoriatic arthropathy 225.76 11.21 3 183896 74005 56034163
Fatigue 222.02 11.21 1589 182310 786963 55321205
Maternal exposure before pregnancy 218.35 11.21 180 183719 6643 56101525
Contusion 217.49 11.21 74 183825 128356 55979812
Metastases to lymph nodes 215.23 11.21 185 183714 7238 56100930
Acute lymphocytic leukaemia 210.75 11.21 124 183775 2620 56105548
Congestive cardiomyopathy 208.47 11.21 164 183735 5655 56102513
Venoocclusive disease 208.35 11.21 110 183789 1867 56106301
Helicobacter infection 207.78 11.21 7 183892 73261 56034907
Intentional overdose 206.74 11.21 3 183896 68114 56040054
Hypersensitivity 203.77 11.21 327 183572 256081 55852087
Cytomegalovirus viraemia 200.22 11.21 152 183747 4968 56103200
Breast cancer recurrent 198.08 11.21 138 183761 3937 56104231
Overdose 193.57 11.21 53 183846 105777 56002391
Duodenal ulcer perforation 192.16 11.21 7 183892 68335 56039833
Neutropenic colitis 190.03 11.21 116 183783 2627 56105541
Irritable bowel syndrome 189.13 11.21 8 183891 68450 56039718
Diffuse large B-cell lymphoma refractory 188.32 11.21 86 183813 1046 56107122
BK virus infection 188.12 11.21 120 183779 2944 56105224
Blood cholesterol increased 186.50 11.21 13 183886 72566 56035602
Blood pressure increased 184.26 11.21 124 183775 145052 55963116
Bacteraemia 182.57 11.21 240 183659 15391 56092777
Feeling abnormal 182.16 11.21 105 183794 133497 55974671
Infusion related reaction 180.96 11.21 251 183648 208680 55899488
Aspergillus infection 180.67 11.21 168 183731 7297 56100871
Pericarditis 178.87 11.21 66 183833 108857 55999311
Adenovirus infection 178.85 11.21 121 183778 3287 56104881
Drug intolerance 175.63 11.21 377 183522 264441 55843727
Lymphopenia 175.31 11.21 244 183655 16530 56091638
Metastases to central nervous system 174.83 11.21 207 183692 11929 56096239
Malaise 173.02 11.21 619 183280 367241 55740927
Human herpesvirus 6 infection 172.06 11.21 108 183791 2574 56105594
Drug resistance 171.70 11.21 269 183630 20273 56087895
Fibromyalgia 167.93 11.21 6 183893 59597 56048571
Graft versus host disease in gastrointestinal tract 165.44 11.21 109 183790 2830 56105338
Peripheral sensory neuropathy 165.37 11.21 155 183744 6801 56101367
Injection site erythema 163.52 11.21 28 183871 77420 56030748
Mobility decreased 159.17 11.21 62 183837 98929 56009239
Mucormycosis 156.44 11.21 103 183796 2671 56105497
Cardiac dysfunction 153.87 11.21 90 183809 1880 56106288
Urticaria 153.08 11.21 148 183751 144528 55963640
Osteoarthritis 152.99 11.21 37 183862 80259 56027909
Blood follicle stimulating hormone increased 152.12 11.21 44 183855 114 56108054
Condition aggravated 150.67 11.21 598 183301 344300 55763868
Asthma 150.37 11.21 91 183808 112679 55995489
Arthritis 147.12 11.21 71 183828 99781 56008387
Organising pneumonia 144.68 11.21 128 183771 5207 56102961
Insomnia 144.64 11.21 253 183646 191607 55916561
Metastasis 142.31 11.21 121 183778 4663 56103505
Cytomegalovirus chorioretinitis 141.74 11.21 81 183818 1617 56106551
Polyneuropathy 141.14 11.21 193 183706 12857 56095311
Abdominal pain upper 141.00 11.21 228 183671 178085 55930083
Gait disturbance 140.58 11.21 197 183702 163124 55945044
Neoplasm recurrence 140.20 11.21 92 183807 2372 56105796
Loss of personal independence in daily activities 139.26 11.21 46 183853 81323 56026845
Migraine 138.49 11.21 55 183844 86742 56021426
Depression 138.06 11.21 235 183664 179882 55928286
Inappropriate schedule of product administration 136.10 11.21 51 183848 83336 56024832
Folliculitis 135.22 11.21 12 183887 54967 56053201
Drug abuse 133.10 11.21 29 183870 67581 56040587
Hospitalisation 132.63 11.21 40 183859 74960 56033208
Muscle spasms 132.45 11.21 152 183747 137219 55970949
Injury 132.32 11.21 19 183880 59832 56048336
Stem cell transplant 131.81 11.21 78 183821 1666 56106502
Somnolence 131.03 11.21 207 183692 163206 55944962
Viral haemorrhagic cystitis 131.00 11.21 60 183839 735 56107433
Lymphadenopathy 130.86 11.21 328 183571 34880 56073288
Computerised tomogram thorax abnormal 130.24 11.21 73 183826 1402 56106766
Acute respiratory distress syndrome 129.23 11.21 246 183653 21680 56086488
B-cell lymphoma recurrent 129.08 11.21 49 183850 358 56107810
Impaired healing 129.07 11.21 61 183838 86780 56021388
Epstein-Barr virus associated lymphoproliferative disorder 126.83 11.21 77 183822 1726 56106442
Therapy responder 125.88 11.21 46 183853 298 56107870
Acute graft versus host disease in intestine 125.39 11.21 75 183824 1635 56106533
Confusional state 125.30 11.21 312 183587 207843 55900325
Blister 125.23 11.21 103 183796 108784 55999384
Blood lactate dehydrogenase increased 124.38 11.21 234 183665 20441 56087727
Central nervous system lymphoma 124.08 11.21 72 183827 1481 56106687
Varicella zoster virus infection 122.08 11.21 86 183813 2498 56105670
Hypoxia 120.49 11.21 419 183480 53478 56054690
JC virus infection 120.27 11.21 76 183823 1833 56106335
Bronchitis 118.66 11.21 115 183784 112196 55995972
Enterococcal infection 117.76 11.21 131 183768 7053 56101115
Suicide attempt 117.58 11.21 23 183876 57813 56050355
Wheezing 117.32 11.21 49 183850 74977 56033191
Intentional product misuse 117.06 11.21 15 183884 51489 56056679
Leukaemia recurrent 115.30 11.21 65 183834 1263 56106905
Injection site reaction 115.19 11.21 18 183881 53229 56054939
Pulmonary haemorrhage 115.18 11.21 126 183773 6657 56101511
Lymphocyte count decreased 113.11 11.21 269 183630 27670 56080498
Klebsiella infection 112.89 11.21 133 183766 7623 56100545
Staphylococcal sepsis 111.94 11.21 129 183770 7220 56100948
Chemotherapy 111.56 11.21 66 183833 1409 56106759
Injection site swelling 111.38 11.21 8 183891 43570 56064598
Leukoencephalopathy 110.82 11.21 98 183801 3984 56104184
Primary hypogonadism 110.58 11.21 35 183864 135 56108033
Injection site pruritus 109.21 11.21 7 183892 41924 56066244
Escherichia bacteraemia 108.04 11.21 90 183809 3370 56104798
Drug interaction 107.29 11.21 340 183559 209415 55898753
Colony stimulating factor therapy 107.25 11.21 41 183858 306 56107862
Breast cancer 105.17 11.21 375 183524 48458 56059710
Transplant failure 105.01 11.21 64 183835 1445 56106723
Injection site bruising 101.62 11.21 6 183893 38515 56069653
Systemic mycosis 101.45 11.21 57 183842 1100 56107068
Capillary leak syndrome 101.26 11.21 69 183830 1897 56106271
Systemic candida 101.03 11.21 82 183817 2959 56105209
Multiple sclerosis relapse 99.85 11.21 14 183885 44889 56063279
Pneumonitis 98.93 11.21 276 183623 31288 56076880
Recurrent cancer 98.55 11.21 66 183833 1762 56106406
Ovarian atrophy 98.38 11.21 28 183871 67 56108101
Pulmonary alveolar haemorrhage 97.51 11.21 93 183806 4171 56103997
Neutrophil count abnormal 97.26 11.21 76 183823 2594 56105574
Drug ineffective 95.98 11.21 2281 181618 916708 55191460
Incorrect dose administered 94.78 11.21 27 183872 52520 56055648
Stress 92.87 11.21 38 183861 58872 56049296
Bacterial sepsis 91.94 11.21 85 183814 3664 56104504
Refractory anaemia with an excess of blasts 91.69 11.21 39 183860 395 56107773
Biopsy lung abnormal 91.66 11.21 30 183869 132 56108036
Anti-Muellerian hormone level decreased 91.48 11.21 27 183872 77 56108091
Blood glucose increased 90.29 11.21 68 183831 75083 56033085
Granulocytopenia 90.27 11.21 99 183800 5245 56102923
Secondary immunodeficiency 89.92 11.21 54 183845 1186 56106982
Pneumatosis intestinalis 88.88 11.21 67 183832 2166 56106002
Rhinovirus infection 88.67 11.21 85 183814 3837 56104331
Pneumonia fungal 88.54 11.21 94 183805 4799 56103369
Pericardial effusion 88.52 11.21 241 183658 26934 56081234
Aortitis 88.48 11.21 50 183849 976 56107192
Invasive ductal breast carcinoma 87.87 11.21 110 183789 6716 56101452
White blood cell count abnormal 87.71 11.21 102 183797 5765 56102403
Adverse drug reaction 87.58 11.21 52 183847 65080 56043088
Balance disorder 87.21 11.21 73 183826 76447 56031721
Lupus nephritis 86.91 11.21 72 183827 2675 56105493
Respiratory syncytial virus infection 86.80 11.21 98 183801 5363 56102805
Acquired haemophilia 85.88 11.21 49 183850 975 56107193
Product use issue 85.32 11.21 316 183583 185725 55922443
Hepatic failure 85.22 11.21 272 183627 33214 56074954
Cytomegalovirus test positive 85.13 11.21 72 183827 2754 56105414
Type 2 diabetes mellitus 84.67 11.21 24 183875 46838 56061330
Hepatic function abnormal 84.59 11.21 277 183622 34281 56073887
Subclavian vein thrombosis 84.30 11.21 60 183839 1772 56106396
Pre-existing disease 83.56 11.21 29 183870 158 56108010
Product quality issue 83.55 11.21 5 183894 31731 56076437
Fungaemia 82.93 11.21 63 183836 2061 56106107
Smooth muscle cell neoplasm 82.44 11.21 44 183855 764 56107404
Ill-defined disorder 82.38 11.21 62 183837 68481 56039687
B-cell type acute leukaemia 81.21 11.21 27 183872 126 56108042
Colitis 80.74 11.21 310 183589 41501 56066667
Anti-neutrophil cytoplasmic antibody positive vasculitis 80.27 11.21 67 183832 2516 56105652
Pseudocirrhosis 80.09 11.21 40 183859 601 56107567
Disseminated intravascular coagulation 79.87 11.21 179 183720 17706 56090462
Clostridium difficile colitis 79.76 11.21 184 183715 18554 56089614
Herpes simplex 79.51 11.21 110 183789 7408 56100760
Ascites 78.87 11.21 286 183613 37258 56070910
International normalised ratio increased 78.75 11.21 23 183876 44018 56064150
Enterococcal bacteraemia 78.57 11.21 51 183848 1290 56106878
Gastrooesophageal reflux disease 78.20 11.21 94 183805 83163 56025005
Myeloid leukaemia 77.49 11.21 32 183867 299 56107869
Blood luteinising hormone increased 77.41 11.21 24 183875 85 56108083
Pneumonia cytomegaloviral 77.01 11.21 59 183840 1955 56106213
Heart rate decreased 76.27 11.21 19 183880 40408 56067760
Adverse event 76.18 11.21 43 183856 55333 56052835
Acute graft versus host disease in liver 75.36 11.21 39 183860 634 56107534
Weight decreased 75.26 11.21 469 183430 240245 55867923
Gene mutation 74.97 11.21 51 183848 1398 56106770
Lung infiltration 74.70 11.21 149 183750 13589 56094579
Lennox-Gastaut syndrome 74.41 11.21 30 183869 262 56107906
Venous thrombosis 74.18 11.21 83 183816 4497 56103671
Blood pressure fluctuation 74.17 11.21 20 183879 40340 56067828
C-reactive protein abnormal 74.06 11.21 15 183884 36794 56071374
Pneumocystis jirovecii infection 73.67 11.21 49 183850 1293 56106875
Myelopathy 72.74 11.21 64 183835 2584 56105584
Suicidal ideation 72.30 11.21 50 183849 57692 56050476
Brain abscess 72.13 11.21 56 183843 1893 56106275
Leukaemia cutis 72.06 11.21 22 183877 73 56108095
Acute myelomonocytic leukaemia 72.00 11.21 26 183873 162 56108006
Amenorrhoea 71.40 11.21 115 183784 8871 56099297
Staphylococcal infection 71.08 11.21 277 183622 37341 56070827
Joint injury 70.84 11.21 3 183896 25651 56082517
Infection reactivation 70.83 11.21 44 183855 1029 56107139
Nasal congestion 70.33 11.21 49 183850 56321 56051847
Blood pressure systolic increased 70.01 11.21 23 183876 40813 56067355
Hepatotoxicity 69.45 11.21 242 183657 30911 56077257
Bone marrow disorder 69.06 11.21 56 183843 2018 56106150
Memory impairment 69.00 11.21 110 183789 86447 56021721
Engraftment syndrome 68.94 11.21 32 183867 405 56107763
Urinary tract infection 68.93 11.21 481 183418 240032 55868136
Hyperpyrexia 68.59 11.21 68 183831 3200 56104968
Pseudomonal sepsis 68.55 11.21 57 183842 2129 56106039
Sedation 68.49 11.21 15 183884 34839 56073329
Ventricular hypokinesia 67.82 11.21 76 183823 4125 56104043
Nephrolithiasis 67.67 11.21 19 183880 37316 56070852
Metastases to pleura 67.63 11.21 47 183852 1335 56106833
Chronic graft versus host disease in skin 66.84 11.21 37 183862 693 56107475
Fusarium infection 66.82 11.21 35 183864 584 56107584
Palpitations 66.70 11.21 141 183758 99531 56008637
Embolism 66.55 11.21 100 183799 7264 56100904
Lower respiratory tract infection 65.23 11.21 177 183722 114617 55993551
Dry mouth 65.21 11.21 68 183831 64137 56044031
Chronic obstructive pulmonary disease 65.14 11.21 55 183844 57360 56050808
Alopecia areata 65.10 11.21 47 183852 1420 56106748
Osteonecrosis 65.03 11.21 195 183704 23020 56085148
Acute leukaemia 64.79 11.21 42 183857 1060 56107108
B-cell lymphoma 64.78 11.21 67 183832 3317 56104851
Acute monocytic leukaemia 64.78 11.21 22 183877 111 56108057
Myocarditis 64.51 11.21 109 183790 8749 56099419
Cerebrovascular accident 64.30 11.21 143 183756 99127 56009041
Unevaluable event 64.21 11.21 38 183861 47649 56060519
Hip arthroplasty 64.06 11.21 23 183876 38600 56069568
Hypoglycaemia 63.90 11.21 53 183846 55762 56052406
Peripheral motor neuropathy 62.84 11.21 47 183852 1501 56106667
Aplastic anaemia 62.57 11.21 108 183791 8820 56099348
Refractory cytopenia with multilineage dysplasia 62.48 11.21 22 183877 126 56108042
Chronic lymphocytic leukaemia 62.39 11.21 62 183837 2926 56105242
Plasma cell leukaemia 62.07 11.21 42 183857 1141 56107027
Gastrointestinal toxicity 62.02 11.21 88 183811 6068 56102100
Serotonin syndrome 61.95 11.21 7 183892 26483 56081685
Skin toxicity 61.75 11.21 72 183827 4081 56104087
Illness 61.74 11.21 18 183881 34493 56073675
Neck pain 61.61 11.21 66 183833 61489 56046679
Alveolar soft part sarcoma 61.29 11.21 20 183879 87 56108081
Splenomegaly 61.05 11.21 115 183784 10053 56098115
Osteosarcoma 60.93 11.21 22 183877 137 56108031
Chronic myelomonocytic leukaemia 60.65 11.21 27 183872 308 56107860
Candida infection 59.49 11.21 202 183697 25465 56082703
Foot deformity 59.12 11.21 5 183894 23820 56084348
Chronic myeloid leukaemia 58.87 11.21 57 183842 2605 56105563
Strongyloidiasis 58.83 11.21 41 183858 1170 56106998
Multiple sclerosis 58.78 11.21 10 183889 27792 56080376
Plasma cell myeloma recurrent 58.74 11.21 58 183841 2716 56105452
Alveolitis 58.67 11.21 57 183842 2616 56105552
Metastases to skin 58.59 11.21 44 183855 1414 56106754
Musculoskeletal pain 58.41 11.21 110 183789 81042 56027126
Maternal exposure during pregnancy 58.35 11.21 371 183528 189182 55918986
Emotional distress 58.09 11.21 13 183886 29750 56078418
Hypertransaminasaemia 57.65 11.21 74 183825 4633 56103535
Drug withdrawal syndrome 57.63 11.21 8 183891 25849 56082319
Proteinuria 57.40 11.21 156 183743 17414 56090754
Enterobacter infection 57.18 11.21 50 183849 2002 56106166
Alpha haemolytic streptococcal infection 56.95 11.21 40 183859 1156 56107012
Sleep disorder 56.80 11.21 83 183816 67580 56040588
Drug ineffective for unapproved indication 56.76 11.21 199 183700 25494 56082674
Myocardial infarction 56.76 11.21 138 183761 92732 56015436
Pulmonary embolism 56.69 11.21 567 183332 106557 56001611
Medication error 56.63 11.21 34 183865 42301 56065867
Flatulence 56.56 11.21 16 183883 31272 56076896
Idiopathic pneumonia syndrome 56.23 11.21 26 183873 326 56107842
Multifocal micronodular pneumocyte hyperplasia 56.16 11.21 18 183881 73 56108095
Bronchial polyp 56.16 11.21 18 183881 73 56108095
Hallucination 55.86 11.21 47 183852 49102 56059066
Upper respiratory fungal infection 55.84 11.21 21 183878 149 56108019
Cataract 55.83 11.21 51 183848 51196 56056972
Joint stiffness 55.59 11.21 23 183876 35402 56072766
Complications of bone marrow transplant 55.06 11.21 28 183871 438 56107730
Neutropenic infection 54.75 11.21 38 183861 1077 56107091
Surgery 54.46 11.21 19 183880 32467 56075701
Nocardiosis 54.33 11.21 46 183853 1762 56106406
Alveolar proteinosis 54.10 11.21 25 183874 313 56107855
Acne 53.67 11.21 4 183895 21132 56087036
Blood stem cell transplant failure 53.66 11.21 20 183879 138 56108030
Premature delivery 53.37 11.21 202 183697 26858 56081310
Gastric disorder 53.03 11.21 21 183878 33189 56074979
Toxic cardiomyopathy 52.80 11.21 19 183880 117 56108051
Nephrotic syndrome 52.27 11.21 75 183824 5225 56102943
Viraemia 52.24 11.21 37 183862 1084 56107084
Invasive lobular breast carcinoma 52.22 11.21 33 183866 796 56107372
Cytomegalovirus colitis 52.21 11.21 48 183851 2054 56106114
Fluid retention 51.91 11.21 60 183839 54018 56054150
Prescribed overdose 51.87 11.21 6 183893 22290 56085878
Dry eye 51.67 11.21 26 183873 35690 56072478
Mitral valve incompetence 51.34 11.21 153 183746 18000 56090168
Dyspepsia 51.03 11.21 124 183775 83347 56024821
Road traffic accident 51.01 11.21 14 183885 27913 56080255
Jugular vein thrombosis 50.98 11.21 54 183845 2749 56105419
Meningitis cryptococcal 50.93 11.21 38 183861 1209 56106959
Hypertension 50.90 11.21 531 183368 243747 55864421
Nephropathy toxic 50.65 11.21 96 183803 8431 56099737
Femur fracture 50.57 11.21 33 183866 39262 56068906
Radiation skin injury 50.45 11.21 33 183866 846 56107322
Acute myeloid leukaemia recurrent 50.33 11.21 41 183858 1487 56106681
Bone marrow transplant 50.27 11.21 30 183869 651 56107517
Ear infection 49.62 11.21 20 183879 31275 56076893
Disseminated mucormycosis 49.57 11.21 19 183880 143 56108025
Acute pulmonary oedema 49.49 11.21 89 183810 7508 56100660
Cardiomyopathy acute 49.43 11.21 21 183878 212 56107956
Chronic lymphocytic leukaemia recurrent 49.08 11.21 20 183879 180 56107988
Leukaemia 48.86 11.21 61 183838 3714 56104454
Osteolysis 48.70 11.21 51 183848 2562 56105606
Pneumomediastinum 48.63 11.21 38 183861 1297 56106871
Nervousness 48.59 11.21 17 183882 28998 56079170
Left ventricular dilatation 48.53 11.21 26 183873 455 56107713
Pneumonia 48.40 11.21 1703 182196 405395 55702773
Hypoalbuminaemia 48.36 11.21 107 183792 10492 56097676
Oedema peripheral 48.29 11.21 344 183555 170910 55937258
Influenza 48.23 11.21 155 183744 95106 56013062
Bursitis 48.23 11.21 15 183884 27567 56080601
Encephalitis 47.95 11.21 91 183808 7999 56100169
Encephalitis viral 47.91 11.21 41 183858 1594 56106574
Lactic acidosis 47.82 11.21 28 183871 35318 56072850
Cutaneous calcification 47.76 11.21 17 183882 101 56108067
Rash pruritic 47.68 11.21 61 183838 52533 56055635
Sciatica 47.58 11.21 13 183886 25997 56082171
Pseudomonas infection 47.46 11.21 103 183796 9968 56098200
Therapy non-responder 47.29 11.21 353 183546 61002 56047166
Obliterative bronchiolitis 47.06 11.21 44 183855 1924 56106244
Mantle cell lymphoma recurrent 46.90 11.21 18 183881 136 56108032
Gastrointestinal necrosis 46.72 11.21 50 183849 2576 56105592
Klebsiella bacteraemia 46.19 11.21 38 183861 1398 56106770
Lymphoma transformation 46.12 11.21 18 183881 143 56108025
Myeloproliferative neoplasm 45.99 11.21 25 183874 451 56107717
Amnesia 45.99 11.21 50 183849 46272 56061896
Plasmacytoma 45.73 11.21 48 183851 2418 56105750
Product prescribing error 45.51 11.21 10 183889 23176 56084992
5q minus syndrome 45.49 11.21 20 183879 221 56107947
Microangiopathic haemolytic anaemia 45.10 11.21 26 183873 528 56107640
Lymphoma 45.04 11.21 103 183796 10325 56097843
Intestinal perforation 44.87 11.21 106 183793 10853 56097315
Autoimmune haemolytic anaemia 44.37 11.21 62 183837 4214 56103954
Device related thrombosis 44.34 11.21 39 183860 1574 56106594
Vasculitis 44.33 11.21 128 183771 14795 56093373
Encephalopathy 44.06 11.21 230 183669 35095 56073073
Nephroblastoma 43.87 11.21 16 183883 103 56108065
Device dislocation 43.87 11.21 10 183889 22596 56085572
Foot fracture 43.64 11.21 9 183890 21800 56086368
Primary amyloidosis 43.44 11.21 14 183885 58 56108110
Parainfluenzae virus infection 43.31 11.21 43 183856 2027 56106141
Loss of consciousness 43.05 11.21 197 183702 109152 55999016
Atelectasis 43.04 11.21 150 183749 19158 56089010
B-cell lymphoma refractory 43.03 11.21 15 183884 83 56108085
Periarticular thenar erythema with onycholysis 43.01 11.21 11 183888 14 56108154
Humoral immune defect 42.88 11.21 15 183884 84 56108084
Refractory cytopenia with unilineage dysplasia 42.83 11.21 25 183874 520 56107648
Cervix disorder 42.58 11.21 25 183874 526 56107642
Back pain 42.57 11.21 533 183366 236637 55871531
Treatment noncompliance 42.52 11.21 27 183872 32596 56075572
Coronary artery disease 42.23 11.21 24 183875 30772 56077396
Encephalitis cytomegalovirus 42.12 11.21 25 183874 537 56107631
Agitation 42.07 11.21 74 183825 55962 56052206
Frequent bowel movements 42.01 11.21 3 183896 16421 56091747
Acute hepatitis B 41.84 11.21 21 183878 319 56107849
Macular degeneration 41.79 11.21 6 183893 18902 56089266
T-cell lymphoma 41.77 11.21 27 183872 678 56107490
Death 41.73 11.21 1433 182466 339993 55768175
Human polyomavirus infection 41.55 11.21 20 183879 276 56107892
Madarosis 41.38 11.21 48 183851 2705 56105463
Systemic scleroderma 41.34 11.21 30 183869 914 56107254
Therapy interrupted 41.25 11.21 16 183883 25609 56082559
Swollen tongue 41.06 11.21 24 183875 30300 56077868
Skin laceration 40.99 11.21 8 183891 20148 56088020
Limb injury 40.98 11.21 11 183888 22259 56085909
Hypoaesthesia 40.97 11.21 282 183617 141209 55966959
Angioedema 40.87 11.21 45 183854 41408 56066760
Lumbosacral radiculoplexus neuropathy 40.67 11.21 11 183888 20 56108148
Burning sensation 40.61 11.21 60 183839 48636 56059532
Crying 40.59 11.21 10 183889 21430 56086738
Metastases to the mediastinum 40.47 11.21 23 183876 454 56107714
Device related infection 40.42 11.21 160 183739 21720 56086448
Extravasation 40.19 11.21 42 183857 2105 56106063
Human bocavirus infection 39.79 11.21 21 183878 356 56107812
Clostridium bacteraemia 39.64 11.21 17 183882 176 56107992
Haematochezia 39.33 11.21 51 183848 43667 56064501
Portal hypertension 39.24 11.21 53 183846 3488 56104680
Red blood cell sedimentation rate increased 39.24 11.21 37 183862 36586 56071582
Lupus vasculitis 39.13 11.21 23 183876 485 56107683
Angiocentric lymphoma 38.77 11.21 25 183874 625 56107543
Blast cells present 38.72 11.21 21 183878 377 56107791
Disease susceptibility 38.65 11.21 17 183882 188 56107980
Therapeutic response unexpected 38.64 11.21 5 183894 17039 56091129
Sinus disorder 38.61 11.21 10 183889 20724 56087444
Cryptococcosis 38.59 11.21 30 183869 1016 56107152
Eye swelling 38.51 11.21 11 183888 21365 56086803
Nodular regenerative hyperplasia 38.46 11.21 22 183877 440 56107728
Gait inability 38.43 11.21 48 183851 41770 56066398
Aggression 38.42 11.21 12 183887 21994 56086174
Acquired gene mutation 38.41 11.21 28 183871 859 56107309
Tremor 38.27 11.21 235 183664 120854 55987314
Lymphadenitis 38.13 11.21 48 183851 2947 56105221
Engraft failure 38.11 11.21 20 183879 335 56107833
Musculoskeletal disorder 38.11 11.21 8 183891 19139 56089029
Lower limb fracture 38.11 11.21 6 183893 17649 56090519
Osteonecrosis of jaw 38.08 11.21 212 183687 33146 56075022
Quadriplegia 38.03 11.21 37 183862 1701 56106467
Ileus paralytic 37.95 11.21 57 183842 4138 56104030
Herpes zoster meningoencephalitis 37.83 11.21 19 183880 289 56107879
Blood culture positive 37.83 11.21 58 183841 4288 56103880
Lung consolidation 37.82 11.21 55 183844 3879 56104289
Intervertebral disc protrusion 37.57 11.21 12 183887 21682 56086486
Bacterial infection 37.22 11.21 133 183766 17197 56090971
Oxygen saturation decreased 37.06 11.21 133 183766 78934 56029234
Cytogenetic abnormality 36.97 11.21 22 183877 475 56107693
Hyperhidrosis 36.74 11.21 170 183729 93918 56014250
Klebsiella sepsis 36.56 11.21 31 183868 1190 56106978
Cardiac failure acute 36.52 11.21 86 183813 8787 56099381
Seasonal allergy 36.51 11.21 6 183893 17102 56091066
Heart rate increased 36.48 11.21 144 183755 83129 56025039
Human herpesvirus 8 infection 36.43 11.21 17 183882 218 56107950
Dyspnoea 36.10 11.21 1576 182323 591001 55517167
Alternaria infection 36.09 11.21 17 183882 223 56107945
Injection site rash 36.07 11.21 6 183893 16952 56091216
Vision blurred 35.98 11.21 144 183755 82799 56025369
Hyperferritinaemia 35.97 11.21 15 183884 144 56108024
Panic attack 35.97 11.21 11 183888 20436 56087732
Adult T-cell lymphoma/leukaemia 35.90 11.21 19 183880 324 56107844
Osteomyelitis bacterial 35.83 11.21 16 183883 184 56107984
Nightmare 35.69 11.21 6 183893 16820 56091348
Hip fracture 35.60 11.21 22 183877 26951 56081217
Pneumothorax 35.33 11.21 118 183781 14749 56093419
Localised infection 35.30 11.21 23 183876 27389 56080779
Depressed mood 35.26 11.21 40 183859 36319 56071849
Plasmablastic lymphoma 35.26 11.21 18 183881 284 56107884
Irritability 35.24 11.21 27 183872 29561 56078607
Kidney infection 34.95 11.21 12 183887 20713 56087455
Disability 34.89 11.21 5 183894 15775 56092393
Escherichia sepsis 34.86 11.21 57 183842 4452 56103716
B precursor type acute leukaemia 34.86 11.21 16 183883 197 56107971
Exostosis 34.82 11.21 4 183895 14939 56093229
Streptococcal bacteraemia 34.71 11.21 33 183866 1474 56106694
Prescribed underdose 34.66 11.21 12 183887 20605 56087563
Restlessness 34.66 11.21 22 183877 26564 56081604
Gastrosplenic fistula 34.44 11.21 11 183888 44 56108124
Thyroid disorder 34.38 11.21 3 183896 13935 56094233
Accidental overdose 34.24 11.21 12 183887 20449 56087719
Dysplasia 34.03 11.21 26 183873 858 56107310
Hyperkalaemia 33.98 11.21 72 183827 50793 56057375
Perineal infection 33.88 11.21 14 183885 131 56108037
Hepatomegaly 33.77 11.21 97 183802 11178 56096990
Clonal evolution 33.75 11.21 12 183887 71 56108097
Toxoplasmosis 33.65 11.21 32 183867 1430 56106738
Hydrothorax 33.63 11.21 25 183874 791 56107377
Graft versus host disease in liver 33.54 11.21 21 183878 498 56107670
Ocular hyperaemia 33.32 11.21 15 183884 21964 56086204
Primary cardiac lymphoma 33.26 11.21 10 183889 31 56108137
Tendonitis 33.19 11.21 9 183890 18088 56090080
Paraparesis 33.14 11.21 38 183861 2115 56106053
Choriocarcinoma 32.91 11.21 13 183886 107 56108061
Adenoviral hepatitis 32.71 11.21 18 183881 333 56107835
Bradycardia 32.68 11.21 112 183787 67392 56040776
Lip swelling 32.55 11.21 23 183876 26249 56081919
Minimal residual disease 32.50 11.21 13 183886 111 56108057
B-lymphocyte count abnormal 32.47 11.21 11 183888 55 56108113
Candida sepsis 32.47 11.21 30 183869 1292 56106876
Unintentional medical device removal 32.46 11.21 63 183836 5631 56102537
Desmoplastic small round cell tumour 32.45 11.21 15 183884 188 56107980
Disseminated toxoplasmosis 32.40 11.21 13 183886 112 56108056
Withdrawal syndrome 32.35 11.21 10 183889 18452 56089716
Ankle fracture 32.35 11.21 7 183892 16396 56091772
Traumatic lung injury 32.31 11.21 32 183867 1504 56106664
Graft versus host disease in lung 32.24 11.21 18 183881 343 56107825
Perineal necrosis 32.20 11.21 13 183886 114 56108054
Epstein-Barr viraemia 32.18 11.21 26 183873 932 56107236
Miller Fisher syndrome 32.17 11.21 12 183887 83 56108085
Hepatitis E 32.03 11.21 30 183869 1315 56106853
Grip strength decreased 31.93 11.21 7 183892 16249 56091919
Neuroblastoma recurrent 31.71 11.21 10 183889 38 56108130
Hair colour changes 31.58 11.21 43 183856 2852 56105316
Injection site mass 31.46 11.21 8 183891 16785 56091383
Haemoglobin decreased 31.40 11.21 614 183285 133523 55974645
Gastrointestinal fungal infection 31.37 11.21 16 183883 252 56107916
Peripheral T-cell lymphoma unspecified 31.25 11.21 16 183883 254 56107914
Pneumonia bacterial 31.10 11.21 76 183823 7952 56100216
B-cell aplasia 31.09 11.21 11 183888 64 56108104
Guillain-Barre syndrome 31.07 11.21 48 183851 3572 56104596
Therapy cessation 31.07 11.21 26 183873 27238 56080930
Gastroenteritis norovirus 30.97 11.21 34 183865 1803 56106365
Pulmonary toxicity 30.93 11.21 75 183824 7808 56100360
IIIrd nerve paralysis 30.81 11.21 22 183877 653 56107515
Cystitis viral 30.79 11.21 13 183886 129 56108039
Triple negative breast cancer 30.72 11.21 15 183884 214 56107954
Administration site extravasation 30.68 11.21 23 183876 737 56107431
Retinal haemorrhage 30.61 11.21 55 183844 4636 56103532
Throat irritation 30.57 11.21 37 183862 32646 56075522
Systolic dysfunction 30.57 11.21 31 183868 1499 56106669
Haematuria 30.47 11.21 171 183728 26816 56081352
Enterococcal sepsis 30.40 11.21 29 183870 1301 56106867
Joint range of motion decreased 30.40 11.21 23 183876 25342 56082826
Laryngitis fungal 30.36 11.21 13 183886 134 56108034
Metastases to peritoneum 30.35 11.21 43 183856 2961 56105207
Granulomatosis with polyangiitis 30.33 11.21 36 183863 2079 56106089
Adenovirus reactivation 30.28 11.21 13 183886 135 56108033
Mantle cell lymphoma 30.26 11.21 21 183878 595 56107573
Erythropoiesis abnormal 30.23 11.21 16 183883 273 56107895
Incorrect route of product administration 30.15 11.21 16 183883 21313 56086855
Lymphadenopathy mediastinal 30.08 11.21 40 183859 2593 56105575
Mood altered 30.08 11.21 4 183895 13351 56094817
Procedural pain 30.01 11.21 8 183891 16263 56091905
Combined immunodeficiency 29.94 11.21 12 183887 103 56108065
Pulmonary veno-occlusive disease 29.82 11.21 26 183873 1037 56107131
Carbohydrate antigen 15-3 increased 29.59 11.21 28 183871 1243 56106925
Respiratory distress 29.59 11.21 191 183708 31476 56076692
Limb discomfort 29.59 11.21 26 183873 26596 56081572
Glomerulonephritis membranous 29.54 11.21 21 183878 619 56107549
Babesiosis 29.48 11.21 15 183884 235 56107933
Disseminated cryptococcosis 29.47 11.21 18 183881 408 56107760
Respiratory arrest 29.36 11.21 34 183865 30591 56077577
Hepatocellular injury 29.27 11.21 167 183732 26347 56081821
Abortion spontaneous 29.17 11.21 62 183837 43691 56064477
Epstein Barr virus positive mucocutaneous ulcer 29.16 11.21 18 183881 416 56107752
Sopor 29.12 11.21 16 183883 20906 56087262
Citrobacter bacteraemia 29.08 11.21 8 183891 16 56108152
Cerebral toxoplasmosis 28.98 11.21 23 183876 803 56107365
Gas gangrene 28.98 11.21 12 183887 113 56108055
Eye irritation 28.83 11.21 13 183886 19015 56089153
Acute interstitial pneumonitis 28.82 11.21 21 183878 644 56107524
Symptom masked 28.70 11.21 21 183878 648 56107520
Nasal septum disorder 28.70 11.21 12 183887 116 56108052
Metastases to chest wall 28.68 11.21 19 183880 498 56107670
Oesophageal candidiasis 28.65 11.21 57 183842 5188 56102980
Joint dislocation 28.63 11.21 8 183891 15765 56092403
Hyperviscosity syndrome 28.62 11.21 13 183886 156 56108012
Metastases to bone marrow 28.56 11.21 16 183883 307 56107861
Chronic kidney disease 28.54 11.21 59 183840 41997 56066171
Malignant transformation 28.53 11.21 17 183882 368 56107800
Cerebral venous sinus thrombosis 28.42 11.21 32 183867 1746 56106422
Transaminases increased 28.41 11.21 176 183723 28594 56079574
Rash macular 28.33 11.21 16 183883 20588 56087580
Polyomavirus-associated nephropathy 28.21 11.21 31 183868 1646 56106522
Diffuse alveolar damage 28.17 11.21 23 183876 837 56107331
Fear 28.13 11.21 7 183892 14901 56093267
Carpal tunnel syndrome 28.11 11.21 12 183887 18132 56090036
Skin discolouration 28.00 11.21 43 183856 34313 56073855
Infection 27.96 11.21 854 183045 199352 55908816
Primary mediastinal large B-cell lymphoma recurrent 27.87 11.21 10 183889 61 56108107
Hepatosplenic T-cell lymphoma 27.83 11.21 20 183879 600 56107568
HER2 positive breast cancer 27.81 11.21 17 183882 386 56107782
Product complaint 27.77 11.21 3 183896 11757 56096411
Cardiac cirrhosis 27.75 11.21 12 183887 127 56108041
Haemolytic anaemia 27.74 11.21 82 183817 9603 56098565
Metastatic malignant melanoma 27.63 11.21 29 183870 1461 56106707
Glaucoma 27.60 11.21 11 183888 17318 56090850
Orthostatic hypotension 27.59 11.21 41 183858 33158 56075010
Cardiogenic shock 27.48 11.21 116 183783 16209 56091959
Computerised tomogram thorax 27.47 11.21 14 183885 220 56107948
Lupus-like syndrome 27.33 11.21 4 183895 12423 56095745
Trichosporon infection 27.28 11.21 15 183884 277 56107891
Visual impairment 27.26 11.21 137 183762 74065 56034103
Labelled drug-drug interaction medication error 27.25 11.21 3 183896 11583 56096585
Necrotising gastritis 27.21 11.21 10 183889 66 56108102
Large intestinal ulcer perforation 27.08 11.21 10 183889 67 56108101
Myelitis 27.07 11.21 27 183872 1280 56106888
Central nervous system infection 26.99 11.21 21 183878 712 56107456
Stomatitis 26.93 11.21 549 183350 120261 55987907
Listeria sepsis 26.92 11.21 20 183879 632 56107536
Ligament sprain 26.91 11.21 3 183896 11472 56096696
Pneumonitis chemical 26.91 11.21 13 183886 181 56107987
Colitis ulcerative 26.89 11.21 24 183875 24367 56083801
Muscle spasticity 26.73 11.21 16 183883 19944 56088224
Sinus congestion 26.70 11.21 9 183890 15715 56092453
Lymphocytosis 26.63 11.21 35 183864 2243 56105925
Lung diffusion test decreased 26.57 11.21 20 183879 645 56107523
High-grade B-cell lymphoma 26.56 11.21 8 183891 25 56108143
Subdural hygroma 26.55 11.21 14 183885 237 56107931
Superior vena cava syndrome 26.54 11.21 20 183879 646 56107522
Acute lymphocytic leukaemia refractory 26.47 11.21 10 183889 72 56108096
Hormone receptor positive breast cancer 26.44 11.21 18 183881 494 56107674
Gestational trophoblastic tumour 26.40 11.21 9 183890 46 56108122
Respiratory tract congestion 26.34 11.21 9 183890 15582 56092586
Premature labour 26.21 11.21 92 183807 11790 56096378
Feeling jittery 26.21 11.21 4 183895 12042 56096126
Haematocrit decreased 26.20 11.21 208 183691 36621 56071547
Vocal cord paralysis 26.19 11.21 32 183867 1905 56106263
Cyst 26.14 11.21 5 183894 12773 56095395
Gallbladder disorder 26.01 11.21 12 183887 17322 56090846
Sleep apnoea syndrome 26.01 11.21 28 183871 26033 56082135
Cranial nerve disorder 26.00 11.21 18 183881 508 56107660
Hair follicle tumour benign 25.87 11.21 16 183883 371 56107797
Hair texture abnormal 25.87 11.21 46 183853 3846 56104322
Natural killer-cell leukaemia 25.81 11.21 11 183888 112 56108056
Radiation necrosis 25.80 11.21 16 183883 373 56107795
Blood iron decreased 25.70 11.21 5 183894 12622 56095546
Rhabdomyosarcoma recurrent 25.66 11.21 8 183891 29 56108139
Pneumonia influenzal 25.64 11.21 28 183871 1476 56106692
Spinal stenosis 25.64 11.21 7 183892 14007 56094161
Tuberculosis of central nervous system 25.54 11.21 16 183883 380 56107788
Device issue 25.47 11.21 19 183880 21087 56087081
Hepatic lesion 25.39 11.21 48 183851 4207 56103961
Hilar lymphadenopathy 25.37 11.21 24 183875 1065 56107103
BK polyomavirus test positive 25.35 11.21 9 183890 53 56108115
Abdominal compartment syndrome 25.28 11.21 18 183881 532 56107636
Leukaemic lymphoma 25.24 11.21 10 183889 83 56108085
Blood pressure diastolic decreased 25.17 11.21 16 183883 19307 56088861
Pharyngeal inflammation 25.16 11.21 19 183880 616 56107552
Gastroenteritis viral 25.15 11.21 18 183881 20406 56087762
Restless legs syndrome 25.02 11.21 12 183887 16935 56091233
Hypersomnia 25.01 11.21 11 183888 16330 56091838
Mesenteric abscess 24.94 11.21 10 183889 86 56108082
Blood pressure diastolic abnormal 24.90 11.21 4 183895 11594 56096574
Clostridium difficile infection 24.77 11.21 163 183736 27035 56081133
Hypoproteinaemia 24.70 11.21 31 183868 1897 56106271
Blood pressure decreased 24.68 11.21 104 183795 58946 56049222
Hydrocephalus 24.63 11.21 52 183847 4937 56103231
Tumour necrosis 24.61 11.21 20 183879 723 56107445
Salivary gland cancer 24.59 11.21 12 183887 171 56107997
Bone marrow transplant rejection 24.54 11.21 9 183890 59 56108109
Thyroid dermatopathy 24.52 11.21 7 183892 17 56108151
Respiratory tract infection fungal 24.43 11.21 16 183883 411 56107757
Recall phenomenon 24.42 11.21 18 183881 562 56107606
Leukocytosis 24.42 11.21 147 183752 23644 56084524
Lymphangiosis carcinomatosa 24.40 11.21 25 183874 1224 56106944
Scleroderma renal crisis 24.34 11.21 14 183885 283 56107885
Blood calcium decreased 24.32 11.21 25 183874 23744 56084424
Nail pigmentation 24.28 11.21 12 183887 176 56107992
Steroid diabetes 24.18 11.21 23 183876 1028 56107140
Shock 24.08 11.21 137 183762 21591 56086577
Feeling hot 24.05 11.21 64 183835 41723 56066445
Haemoglobin abnormal 23.92 11.21 49 183850 4555 56103613
Bone lesion 23.86 11.21 54 183845 5376 56102792
Arteritis 23.82 11.21 18 183881 584 56107584
Human herpesvirus 7 infection 23.71 11.21 10 183889 99 56108069
Ovarian disorder 23.68 11.21 19 183880 674 56107494
Metastases to meninges 23.68 11.21 33 183866 2237 56105931
Growth hormone deficiency 23.64 11.21 11 183888 140 56108028
Pelvic kidney 23.64 11.21 5 183894 0 56108168
Intracardiac thrombus 23.63 11.21 33 183866 2242 56105926
Escherichia infection 23.62 11.21 88 183811 11611 56096557
Creatinine renal clearance decreased 23.58 11.21 9 183890 14550 56093618
Angioimmunoblastic T-cell lymphoma 23.57 11.21 11 183888 141 56108027
T-cell type acute leukaemia 23.56 11.21 9 183890 67 56108101
Heart rate abnormal 23.48 11.21 48 183851 4455 56103713
Retinal toxicity 23.47 11.21 24 183875 1172 56106996
Paraneoplastic pemphigus 23.45 11.21 9 183890 68 56108100
Mucosal infection 23.44 11.21 11 183888 143 56108025
Microscopic polyangiitis 23.41 11.21 12 183887 191 56107977
Nasal abscess 23.37 11.21 11 183888 144 56108024
Necrosis 23.29 11.21 51 183848 4965 56103203
Soft tissue neoplasm 23.22 11.21 9 183890 70 56108098
Glioma 23.21 11.21 14 183885 310 56107858
Drug effective for unapproved indication 23.20 11.21 35 183864 2551 56105617
Dyskinesia 23.18 11.21 37 183862 29071 56079097
Device breakage 22.94 11.21 3 183896 10144 56098024
Brain oedema 22.89 11.21 95 183804 13176 56094992
Troponin I increased 22.84 11.21 31 183868 2050 56106118
Poor venous access 22.79 11.21 6 183893 12300 56095868
Head injury 22.79 11.21 29 183870 25037 56083131
Adenoviral haemorrhagic cystitis 22.78 11.21 11 183888 153 56108015
Primary mediastinal large B-cell lymphoma 22.75 11.21 7 183892 24 56108144
Enterocolitis infectious 22.66 11.21 27 183872 1566 56106602
Mucocutaneous ulceration 22.65 11.21 11 183888 155 56108013
Platelet count abnormal 22.62 11.21 38 183861 3035 56105133
Antithrombin III 22.59 11.21 11 183888 156 56108012
Inappropriate antidiuretic hormone secretion 22.58 11.21 97 183802 13659 56094509
Morganella infection 22.55 11.21 18 183881 634 56107534
Cytology abnormal 22.51 11.21 6 183893 10 56108158
Soft tissue infection 22.42 11.21 30 183869 1957 56106211
Urinary tract infection bacterial 22.33 11.21 47 183852 4453 56103715
Scedosporium infection 22.32 11.21 16 183883 478 56107690
Enteritis 22.26 11.21 64 183835 7379 56100789
Faeces discoloured 22.24 11.21 14 183885 16982 56091186
Muscle rigidity 22.20 11.21 4 183895 10667 56097501
Ototoxicity 22.17 11.21 23 183876 1143 56107025
Deep vein thrombosis 22.12 11.21 364 183535 76613 56031555
Underdose 22.11 11.21 27 183872 23730 56084438
Rhabdomyolysis 22.11 11.21 64 183835 40594 56067574
PIK3CA-activated mutation 22.11 11.21 21 183878 937 56107231
Postictal state 22.01 11.21 21 183878 942 56107226
Impaired work ability 22.01 11.21 10 183889 14562 56093606
Haematocolpos 22 11.21 8 183891 51 56108117
Chronic graft versus host disease in liver 21.91 11.21 13 183886 279 56107889
Refractory cancer 21.80 11.21 9 183890 84 56108084
Fungal sepsis 21.76 11.21 23 183876 1168 56107000
Epstein-Barr virus associated lymphoma 21.72 11.21 16 183883 499 56107669
Fungal infection 21.67 11.21 183 183716 32810 56075358
Cholecystectomy 21.57 11.21 3 183896 9681 56098487
Leukoerythroblastosis 21.57 11.21 12 183887 227 56107941
Focal nodular hyperplasia 21.56 11.21 16 183883 505 56107663
Metastases to diaphragm 21.53 11.21 7 183892 30 56108138
Cerebellar haemangioma 21.44 11.21 9 183890 88 56108080
Product administration error 21.43 11.21 22 183877 20907 56087261
Poor quality sleep 21.40 11.21 16 183883 17739 56090429
Ear pain 21.24 11.21 43 183856 30847 56077321
Blood lactate dehydrogenase abnormal 21.20 11.21 12 183887 235 56107933
Left ventricular failure 21.19 11.21 49 183850 4947 56103221
Cardiac amyloidosis 21.16 11.21 19 183880 788 56107380
Eye pain 21.16 11.21 43 183856 30804 56077364
Aplasia pure red cell 21.14 11.21 45 183854 4297 56103871
Marrow hyperplasia 21.10 11.21 17 183882 607 56107561
Nervous system disorder 21.08 11.21 110 183789 16779 56091389
Tissue infiltration 21.07 11.21 17 183882 608 56107560
Metabolic acidosis 21.05 11.21 65 183834 40389 56067779
Bone marrow infiltration 21.04 11.21 16 183883 524 56107644
Thrombotic thrombocytopenic purpura 21.04 11.21 41 183858 3676 56104492
Atypical haemolytic uraemic syndrome 20.86 11.21 17 183882 617 56107551
Diffuse large B-cell lymphoma stage IV 20.85 11.21 13 183886 306 56107862
Delayed engraftment 20.83 11.21 9 183890 95 56108073
Cholelithiasis 20.82 11.21 63 183836 39401 56068767
Cerebellar stroke 20.76 11.21 12 183887 245 56107923
Necrotising colitis 20.73 11.21 16 183883 536 56107632
Opportunistic infection 20.72 11.21 27 183872 1716 56106452
Cryptosporidiosis infection 20.70 11.21 13 183886 310 56107858
Malignant pleural effusion 20.69 11.21 32 183867 2384 56105784
Febrile infection 20.67 11.21 24 183875 1354 56106814
Acute megakaryocytic leukaemia 20.66 11.21 7 183892 35 56108133
Drug tolerance decreased 20.57 11.21 9 183890 13402 56094766
Acute biphenotypic leukaemia 20.56 11.21 8 183891 63 56108105
Groin pain 20.56 11.21 3 183896 9337 56098831
Hepatosplenomegaly 20.52 11.21 32 183867 2401 56105767
Appendiceal abscess 20.51 11.21 11 183888 193 56107975
Diabetes mellitus inadequate control 20.49 11.21 10 183889 13970 56094198
Transient ischaemic attack 20.42 11.21 50 183849 33527 56074641
Hepatic infarction 20.42 11.21 17 183882 636 56107532
Cholangiocarcinoma 20.39 11.21 22 183877 1144 56107024
Toxicity to various agents 20.36 11.21 568 183331 223996 55884172
Epstein-Barr virus infection reactivation 20.35 11.21 17 183882 639 56107529
Syphilis 20.34 11.21 10 183889 145 56108023
Diabetic ketoacidosis 20.29 11.21 19 183880 18852 56089316
Granulocyte count decreased 20.24 11.21 20 183879 937 56107231
Pregnancy 20.24 11.21 49 183850 32984 56075184
Enteral nutrition 20.19 11.21 7 183892 38 56108130
Pseudomembranous colitis 20.19 11.21 35 183864 2868 56105300
Drug reaction with eosinophilia and systemic symptoms 20.15 11.21 43 183856 30261 56077907
Sneezing 20.11 11.21 13 183886 15547 56092621
Cryoglobulinaemia 20.08 11.21 15 183884 478 56107690
Product storage error 20.06 11.21 9 183890 13204 56094964
Mediastinum neoplasm 20.03 11.21 8 183891 68 56108100
Blood creatine phosphokinase increased 20.01 11.21 38 183861 27914 56080254
Immune thrombocytopenia 19.93 11.21 73 183826 9552 56098616
Bone marrow necrosis 19.93 11.21 8 183891 69 56108099
Mucoepidermoid carcinoma 19.89 11.21 7 183892 40 56108128
Peripheral sensorimotor neuropathy 19.89 11.21 23 183876 1292 56106876
B-lymphocyte count decreased 19.88 11.21 20 183879 958 56107210
Geotrichum infection 19.87 11.21 15 183884 486 56107682
Disseminated strongyloidiasis 19.86 11.21 6 183893 19 56108149
Tooth disorder 19.86 11.21 33 183866 25520 56082648
Hyperbilirubinaemia 19.84 11.21 76 183823 10159 56098009
Autoimmune neutropenia 19.83 11.21 8 183891 70 56108098
Swelling face 19.76 11.21 105 183794 55964 56052204
Body temperature decreased 19.74 11.21 18 183881 18090 56090078
T-cell lymphoma recurrent 19.71 11.21 5 183894 6 56108162
Reversible cerebral vasoconstriction syndrome 19.68 11.21 31 183868 2346 56105822
Paranasal sinus mucosal hypertrophy 19.63 11.21 6 183893 20 56108148
Dystonia 19.59 11.21 8 183891 12413 56095755
Drug dependence 19.54 11.21 27 183872 22506 56085662
Pseudomonal bacteraemia 19.54 11.21 23 183876 1317 56106851
Night sweats 19.52 11.21 69 183830 41144 56067024
Primary immunodeficiency syndrome 19.47 11.21 7 183892 43 56108125
Metastases to spine 19.45 11.21 35 183864 2954 56105214
Malignant neoplasm of pleura 19.44 11.21 8 183891 74 56108094
Malnutrition 19.43 11.21 94 183805 13914 56094254
Forced vital capacity decreased 19.41 11.21 20 183879 986 56107182
Metastases to thorax 19.36 11.21 11 183888 217 56107951
Dysphonia 19.36 11.21 71 183828 41876 56066292
Chest pain 19.34 11.21 472 183427 189325 55918843
Vascular compression 19.31 11.21 9 183890 115 56108053
Mucosal toxicity 19.25 11.21 13 183886 352 56107816
Rash erythematous 19.23 11.21 60 183839 37161 56071007
Neuroblastoma 19.18 11.21 9 183890 117 56108051
Carotid intima-media thickness increased 19.16 11.21 8 183891 77 56108091
Parvovirus infection 19.14 11.21 11 183888 222 56107946
Herpes simplex viraemia 19.14 11.21 10 183889 166 56108002
Lymphoproliferative disorder 19.12 11.21 35 183864 2993 56105175
Basal ganglion degeneration 19.08 11.21 14 183885 434 56107734
Middle insomnia 19.06 11.21 6 183893 10944 56097224
Pelvic fracture 19.05 11.21 8 183891 12205 56095963
Breast neoplasm 19.04 11.21 23 183876 1353 56106815
Metastases to breast 19.04 11.21 12 183887 288 56107880
Skin mass 19.03 11.21 49 183850 5295 56102873
Eye infection 18.96 11.21 5 183894 10239 56097929
Breast angiosarcoma 18.91 11.21 4 183895 0 56108168
Vertigo 18.79 11.21 103 183796 54469 56053699
Blood immunoglobulin G decreased 18.78 11.21 29 183870 2157 56106011
Abdominal pain 18.78 11.21 674 183225 258131 55850037
Bronchiolitis 18.68 11.21 31 183868 2451 56105717
Upper-airway cough syndrome 18.67 11.21 4 183895 9434 56098734
Affect lability 18.63 11.21 5 183894 10120 56098048
Myasthenia gravis crisis 18.61 11.21 14 183885 451 56107717
Endocarditis 18.61 11.21 49 183850 5367 56102801
Listeriosis 18.59 11.21 23 183876 1387 56106781
Hyperuricaemia 18.57 11.21 47 183852 5026 56103142
Vena cava thrombosis 18.56 11.21 28 183871 2041 56106127
Cytomegalovirus enteritis 18.54 11.21 11 183888 236 56107932
Primary adrenal insufficiency 18.52 11.21 9 183890 127 56108041
Cystoid macular oedema 18.52 11.21 24 183875 1517 56106651
Blood glucose decreased 18.51 11.21 21 183878 19066 56089102
Pulmonary infarction 18.41 11.21 31 183868 2481 56105687
Pneumonia pseudomonal 18.41 11.21 29 183870 2195 56105973
Morphoea 18.40 11.21 12 183887 306 56107862
Infusion site streaking 18.37 11.21 14 183885 460 56107708
Pleural disorder 18.34 11.21 15 183884 547 56107621
Eczema 18.33 11.21 36 183863 26117 56082051
Wrong technique in product usage process 18.31 11.21 113 183786 58055 56050113
Pulmonary mucormycosis 18.30 11.21 11 183888 242 56107926
Bronchiectasis 18.29 11.21 80 183819 11354 56096814
Metastases to stomach 18.27 11.21 10 183889 183 56107985
Medulloblastoma recurrent 18.23 11.21 8 183891 88 56108080
Thinking abnormal 18.12 11.21 5 183894 9936 56098232
Hepatitis C RNA increased 18.09 11.21 9 183890 134 56108034
Human herpesvirus 6 encephalitis 18.03 11.21 10 183889 188 56107980
Granulicatella infection 18.00 11.21 7 183892 55 56108113
Haemorrhage intracranial 17.99 11.21 86 183813 12669 56095499
Glycosylated haemoglobin increased 17.92 11.21 7 183892 11158 56097010
Anaesthesia 17.91 11.21 13 183886 396 56107772
Influenza like illness 17.91 11.21 121 183778 60867 56047301
Lung disorder 17.91 11.21 256 183643 52341 56055827
Abdominal neoplasm 17.90 11.21 12 183887 321 56107847
Abnormal behaviour 17.87 11.21 24 183875 20248 56087920
Sinus polyp 17.86 11.21 12 183887 322 56107846
Mediastinitis 17.84 11.21 10 183889 192 56107976
Chylothorax 17.83 11.21 11 183888 254 56107914
Mycobacterial infection 17.83 11.21 25 183874 1705 56106463
Enterobacter bacteraemia 17.79 11.21 11 183888 255 56107913
Germ cell cancer 17.79 11.21 7 183892 57 56108111
Flushing 17.76 11.21 145 183754 69955 56038213
Cancer in remission 17.71 11.21 6 183893 30 56108138
Abdominal distension 17.70 11.21 165 183734 77461 56030707
Anger 17.64 11.21 8 183891 11664 56096504
Post procedural infection 17.61 11.21 3 183896 8329 56099839
Fusobacterium infection 17.55 11.21 6 183893 31 56108137
Cystitis bacterial 17.52 11.21 9 183890 144 56108024
Laryngitis 17.52 11.21 12 183887 13918 56094250
Metaplasia 17.49 11.21 13 183886 411 56107757
Premature baby 17.43 11.21 115 183784 19090 56089078
Hypofibrinogenaemia 17.39 11.21 20 183879 1117 56107051
Incorrect product administration duration 17.38 11.21 6 183893 10320 56097848
Acinetobacter infection 17.34 11.21 23 183876 1487 56106681
Rhinorrhoea 17.34 11.21 112 183787 56925 56051243
Sweat gland tumour 17.32 11.21 8 183891 100 56108068
Campylobacter infection 17.29 11.21 18 183881 898 56107270
Burkitt's lymphoma 17.27 11.21 5 183894 13 56108155
T-cell prolymphocytic leukaemia 17.27 11.21 5 183894 13 56108155
Sarcoidosis 17.25 11.21 48 183851 5432 56102736
COVID-19 pneumonia 17.24 11.21 77 183822 11025 56097143
Tooth fracture 17.24 11.21 6 183893 10270 56097898
Respiratory tract infection 17.21 11.21 187 183712 35884 56072284
Joint neoplasm 17.18 11.21 7 183892 63 56108105
Hepatic necrosis 17.16 11.21 47 183852 5269 56102899
Parkinsonism 17.04 11.21 5 183894 9541 56098627
Opsoclonus myoclonus 17.03 11.21 9 183890 153 56108015
Chest discomfort 17.03 11.21 224 183675 98633 56009535
Pericarditis constrictive 17.02 11.21 12 183887 349 56107819
Endocarditis bacterial 16.98 11.21 15 183884 609 56107559
Gastric stenosis 16.89 11.21 7 183892 66 56108102
Myocardial fibrosis 16.86 11.21 16 183883 713 56107455
Lymphangitis 16.85 11.21 17 183882 817 56107351
Monoparesis 16.80 11.21 23 183876 1533 56106635
Cerebral fungal infection 16.80 11.21 7 183892 67 56108101
Ventricular dysfunction 16.79 11.21 31 183868 2668 56105500
CD4/CD8 ratio decreased 16.75 11.21 5 183894 15 56108153
Gait apraxia 16.75 11.21 5 183894 15 56108153
Rectal haemorrhage 16.73 11.21 74 183825 41393 56066775
Hypermetabolism 16.72 11.21 9 183890 159 56108009
Pyomyositis 16.72 11.21 12 183887 359 56107809
Needle issue 16.69 11.21 4 183895 8734 56099434
Haematopoietic stem cell mobilisation 16.68 11.21 4 183895 3 56108165
Primitive neuroectodermal tumour 16.68 11.21 4 183895 3 56108165
Rubulavirus test positive 16.68 11.21 4 183895 3 56108165
Cytokine abnormal 16.68 11.21 4 183895 3 56108165
Erythropenia 16.67 11.21 9 183890 160 56108008
Single functional kidney 16.67 11.21 9 183890 160 56108008
Jaw operation 16.66 11.21 17 183882 828 56107340
Paraneoplastic syndrome 16.65 11.21 14 183885 531 56107637
Movement disorder 16.65 11.21 23 183876 19175 56088993
Basal cell carcinoma 16.59 11.21 36 183863 25185 56082983
Fungal endocarditis 16.56 11.21 10 183889 222 56107946
Live birth 16.49 11.21 24 183875 19581 56088587
Lower respiratory tract infection fungal 16.48 11.21 11 183888 292 56107876
Generalised oedema 16.44 11.21 92 183807 14409 56093759
Infusion site swelling 16.41 11.21 3 183896 7918 56100250
Toxic neuropathy 16.41 11.21 12 183887 370 56107798
Fasciitis 16.41 11.21 14 183885 542 56107626
Appendicitis 16.37 11.21 57 183842 7275 56100893
Vasogenic cerebral oedema 16.36 11.21 14 183885 544 56107624
Coagulopathy 16.34 11.21 111 183788 18605 56089563
Secretion discharge 16.30 11.21 7 183892 10539 56097629
Epidermal necrosis 16.28 11.21 18 183881 962 56107206
Pulmonary oedema 16.27 11.21 246 183653 50897 56057271
Oral candidiasis 16.22 11.21 111 183788 18652 56089516
Pneumonia aspiration 16.21 11.21 53 183846 32358 56075810
Pneumonia adenoviral 16.21 11.21 8 183891 117 56108051
Pulse waveform abnormal 16.19 11.21 7 183892 74 56108094
Ankle brachial index decreased 16.19 11.21 7 183892 74 56108094
Hemiparesis 16.19 11.21 123 183776 21367 56086801
Neonatal lupus erythematosus 16.15 11.21 4 183895 4 56108164
Conjunctival scar 16.15 11.21 6 183893 41 56108127
Transient hypogammaglobulinaemia of infancy 16.15 11.21 6 183893 41 56108127
Chronic myeloid leukaemia recurrent 16.13 11.21 10 183889 233 56107935
Synovial cyst 16.13 11.21 5 183894 9209 56098959
Meningoencephalitis viral 16.12 11.21 11 183888 303 56107865
Disseminated tuberculosis 16.12 11.21 31 183868 2752 56105416
Gout 16.08 11.21 10 183889 12211 56095957
Central nervous system leukaemia 16.03 11.21 8 183891 120 56108048
Joint effusion 16.02 11.21 15 183884 14883 56093285
Rib fracture 16.00 11.21 26 183873 20283 56087885
Staphylococcus test positive 15.95 11.21 36 183863 3577 56104591
Treatment failure 15.95 11.21 429 183470 169963 55938205
Mycobacterium abscessus infection 15.95 11.21 15 183884 661 56107507
Spinal cord compression 15.93 11.21 37 183862 3747 56104421
Jejunal stenosis 15.90 11.21 6 183893 43 56108125
Amyloidosis 15.89 11.21 19 183880 1106 56107062
VIth nerve paresis 15.87 11.21 7 183892 78 56108090
Skin cancer 15.80 11.21 7 183892 10348 56097820
Paraplegia 15.78 11.21 29 183870 2488 56105680
Onycholysis 15.77 11.21 21 183878 1363 56106805
Haemolysis 15.73 11.21 51 183848 6277 56101891
Hypoperfusion 15.70 11.21 21 183878 1369 56106799
Foetal growth restriction 15.69 11.21 55 183844 7044 56101124
Alopecia 15.68 11.21 791 183108 292667 55815501
Enterocolitis 15.67 11.21 55 183844 7049 56101119
Pneumonia staphylococcal 15.66 11.21 30 183869 2655 56105513
Blood potassium increased 15.66 11.21 20 183879 17241 56090927
Pneumonia respiratory syncytial viral 15.65 11.21 15 183884 677 56107491
Blood pressure abnormal 15.60 11.21 13 183886 13647 56094521
Corynebacterium infection 15.55 11.21 13 183886 489 56107679
Fungal oesophagitis 15.53 11.21 14 183885 584 56107584
Blast cell count increased 15.50 11.21 12 183887 404 56107764
Hypertriglyceridaemia 15.49 11.21 48 183851 5768 56102400
Metastases to uterus 15.48 11.21 7 183892 83 56108085
Congenital syphilitic osteochondritis 15.46 11.21 5 183894 21 56108147
Duodenal stenosis 15.44 11.21 13 183886 494 56107674
Osteoporosis 15.42 11.21 103 183796 51949 56056219
Areflexia 15.41 11.21 31 183868 2844 56105324
Superior mesenteric artery syndrome 15.41 11.21 7 183892 84 56108084
Alopecia totalis 15.39 11.21 11 183888 327 56107841
Listeria encephalitis 15.37 11.21 10 183889 254 56107914
Eye disorder 15.35 11.21 27 183872 20425 56087743
Cerebral aspergillosis 15.35 11.21 12 183887 410 56107758
Peritonitis viral 15.34 11.21 6 183893 48 56108120
Retching 15.29 11.21 13 183886 13517 56094651
Intraductal proliferative breast lesion 15.29 11.21 30 183869 2703 56105465
Hepatic calcification 15.28 11.21 5 183894 22 56108146
Median nerve injury 15.28 11.21 5 183894 22 56108146
Central nervous system enteroviral infection 15.28 11.21 5 183894 22 56108146
Lymph node fibrosis 15.26 11.21 4 183895 6 56108162
Cutaneous mucormycosis 15.26 11.21 4 183895 6 56108162
Non-Hodgkin's lymphoma recurrent 15.26 11.21 4 183895 6 56108162
Hypotelorism of orbit 15.26 11.21 4 183895 6 56108162
Chronic lymphocytic leukaemia transformation 15.23 11.21 6 183893 49 56108119
Water intoxication 15.22 11.21 12 183887 415 56107753
Histiocytic sarcoma 15.19 11.21 7 183892 87 56108081
Chromosome analysis abnormal 15.19 11.21 8 183891 135 56108033
Skin hypopigmentation 15.18 11.21 15 183884 703 56107465
Herpes zoster cutaneous disseminated 15.18 11.21 9 183890 193 56107975
Cardiac tamponade 15.16 11.21 40 183859 4386 56103782
Cytomegalovirus enterocolitis 15.15 11.21 14 183885 603 56107565
Lymphocytic leukaemia 15.14 11.21 8 183891 136 56108032
Arachnoid cyst 15.14 11.21 9 183890 194 56107974
Aphasia 15.12 11.21 159 183740 30256 56077912
Mucosal erosion 15.11 11.21 20 183879 1291 56106877
Leukonychia 15.10 11.21 5 183894 23 56108145
Red blood cell schistocytes present 15.03 11.21 10 183889 264 56107904
Menopause 15.02 11.21 28 183871 2428 56105740
Disorientation 14.98 11.21 65 183834 36548 56071620
Telangiectasia 14.97 11.21 16 183883 823 56107345
Metastatic lymphoma 14.91 11.21 7 183892 91 56108077
Hypogonadism 14.91 11.21 7 183892 91 56108077
Meningitis 14.90 11.21 51 183848 6453 56101715
Reproductive toxicity 14.89 11.21 4 183895 7 56108161
Tachycardia 14.86 11.21 452 183447 105424 56002744
Haptoglobin decreased 14.85 11.21 15 183884 722 56107446
Coma 14.84 11.21 124 183775 59531 56048637
Splenic infarction 14.83 11.21 22 183877 1580 56106588
Upper respiratory tract infection 14.80 11.21 155 183744 71133 56037035
Blood fibrinogen decreased 14.80 11.21 15 183884 725 56107443
Pleurodesis 14.76 11.21 5 183894 25 56108143
Klebsiella test positive 14.76 11.21 17 183882 951 56107217
Bone density decreased 14.75 11.21 12 183887 12748 56095420
Microsporidia infection 14.74 11.21 10 183889 273 56107895
Bladder disorder 14.70 11.21 4 183895 8020 56100148
Monoplegia 14.69 11.21 31 183868 2943 56105225
Cardio-respiratory arrest 14.68 11.21 113 183786 55208 56052960
Pain in jaw 14.66 11.21 74 183825 39962 56068206
Hyperproteinaemia 14.65 11.21 7 183892 95 56108073
Pneumonia pneumococcal 14.65 11.21 24 183875 1878 56106290
Diverticulum 14.64 11.21 9 183890 11057 56097111
Merycism 14.62 11.21 9 183890 207 56107961
Akathisia 14.61 11.21 5 183894 8647 56099521
Viral sepsis 14.60 11.21 5 183894 26 56108142
Leukaemic infiltration 14.60 11.21 5 183894 26 56108142
Blood phosphorus decreased 14.60 11.21 37 183862 3960 56104208
Mood swings 14.59 11.21 20 183879 16727 56091441
Rotator cuff syndrome 14.56 11.21 11 183888 12132 56096036
Central nervous system vasculitis 14.55 11.21 16 183883 850 56107318
Acute generalised exanthematous pustulosis 14.55 11.21 7 183892 9862 56098306
Gastritis fungal 14.52 11.21 7 183892 97 56108071
Deafness 14.51 11.21 98 183801 16396 56091772
Oral disorder 14.47 11.21 59 183840 8116 56100052
Clostridium colitis 14.45 11.21 23 183876 1756 56106412
Pleural neoplasm 14.45 11.21 11 183888 361 56107807
Rosai-Dorfman syndrome 14.44 11.21 5 183894 27 56108141
Artificial menopause 14.44 11.21 5 183894 27 56108141
B-cell small lymphocytic lymphoma 14.44 11.21 5 183894 27 56108141
Tachycardia induced cardiomyopathy 14.44 11.21 6 183893 57 56108111
Tracheo-oesophageal fistula 14.42 11.21 13 183886 542 56107626
Blood pressure systolic abnormal 14.32 11.21 7 183892 9770 56098398
Cachexia 14.30 11.21 42 183857 4900 56103268
Pleuroparenchymal fibroelastosis 14.29 11.21 5 183894 28 56108140
Central nervous system viral infection 14.27 11.21 7 183892 101 56108067
Cholecystitis chronic 14.24 11.21 7 183892 9741 56098427
Human herpes virus 8 test positive 14.22 11.21 4 183895 9 56108159
Spinal cord disorder 14.19 11.21 19 183880 1240 56106928
Radiation injury 14.19 11.21 12 183887 459 56107709
Cardiac failure chronic 14.18 11.21 37 183862 4030 56104138
Ovarian Sertoli-Leydig cell tumour 14.18 11.21 3 183896 0 56108168
Precursor B-lymphoblastic lymphoma recurrent 14.18 11.21 3 183896 0 56108168
Autologous haematopoietic stem cell transplant 14.18 11.21 3 183896 0 56108168
Anal infection 14.17 11.21 6 183893 60 56108108
Metastases to retroperitoneum 14.16 11.21 8 183891 156 56108012
Oedema due to cardiac disease 14.15 11.21 5 183894 29 56108139
TP53 gene mutation 14.15 11.21 5 183894 29 56108139
Hallucination, visual 14.10 11.21 22 183877 17446 56090722
Vitamin D decreased 14.08 11.21 6 183893 9077 56099091
Enterocolitis haemorrhagic 14.07 11.21 20 183879 1381 56106787
Pulmonary fibrosis 14.07 11.21 154 183745 29604 56078564
Dry skin 14.07 11.21 93 183806 47016 56061152
Escherichia urinary tract infection 14.06 11.21 72 183827 10903 56097265
Iron deficiency anaemia 14.06 11.21 23 183876 17896 56090272
Walking aid user 14.05 11.21 5 183894 8438 56099730
Meningitis bacterial 14.04 11.21 19 183880 1253 56106915
Xerophthalmia 14.03 11.21 12 183887 466 56107702
Gastrointestinal mucormycosis 13.99 11.21 9 183890 224 56107944
Atrial thrombosis 13.88 11.21 21 183878 1534 56106634
Haemodynamic instability 13.88 11.21 59 183840 8270 56099898
Rhinocerebral mucormycosis 13.86 11.21 10 183889 302 56107866
Hiatus hernia 13.82 11.21 27 183872 19625 56088543
Neurological decompensation 13.80 11.21 27 183872 2427 56105741
Epstein-Barr virus test positive 13.78 11.21 13 183886 575 56107593
Antineutrophil cytoplasmic antibody increased 13.75 11.21 6 183893 65 56108103
Stenotrophomonas sepsis 13.73 11.21 5 183894 32 56108136
Emotional disorder 13.67 11.21 12 183887 12283 56095885
Mycobacterium chelonae infection 13.67 11.21 12 183887 483 56107685
Endocardial fibrosis 13.66 11.21 4 183895 11 56108157
Cushingoid 13.64 11.21 54 183845 7330 56100838
Hypoglossal nerve paresis 13.62 11.21 7 183892 112 56108056
Therapeutic product effect incomplete 13.61 11.21 254 183645 105777 56002391
Pharyngitis streptococcal 13.61 11.21 7 183892 9491 56098677
Uterine enlargement 13.56 11.21 18 183881 1165 56107003
Dementia 13.48 11.21 22 183877 17136 56091032
Hypokalaemia 13.48 11.21 404 183495 94033 56014135
Blood immunoglobulin A decreased 13.46 11.21 12 183887 493 56107675
Growth retardation 13.42 11.21 18 183881 1177 56106991
Pulmonary necrosis 13.41 11.21 7 183892 116 56108052
Tumour haemorrhage 13.40 11.21 20 183879 1444 56106724
Jejunal ulcer perforation 13.35 11.21 5 183894 35 56108133
Paratracheal lymphadenopathy 13.35 11.21 5 183894 35 56108133
Lymph node pain 13.32 11.21 19 183880 1316 56106852
Pleocytosis 13.31 11.21 14 183885 707 56107461
Philadelphia positive acute lymphocytic leukaemia 13.28 11.21 6 183893 71 56108097
Streptococcal sepsis 13.27 11.21 22 183877 1738 56106430
Oesophagitis 13.26 11.21 85 183814 13972 56094196
Renal failure 13.25 11.21 463 183436 110037 55998131
Fungal skin infection 13.22 11.21 36 183863 4022 56104146
Nail disorder 13.22 11.21 73 183826 11378 56096790
Injection site phlebitis 13.20 11.21 7 183892 120 56108048
Trichodysplasia spinulosa 13.18 11.21 12 183887 507 56107661
Optic atrophy 13.17 11.21 18 183881 1198 56106970
Acral peeling skin syndrome 13.16 11.21 4 183895 13 56108155
Respiratory tract infection bacterial 13.16 11.21 9 183890 249 56107919
Leukaemic infiltration extramedullary 13.14 11.21 6 183893 73 56108095
Papule 13.13 11.21 39 183860 4578 56103590
Precursor T-lymphoblastic lymphoma/leukaemia 13.12 11.21 5 183894 37 56108131
Hallucination, auditory 13.12 11.21 11 183888 11513 56096655
Atrioventricular block first degree 13.11 11.21 3 183896 6762 56101406
Lymphomatoid papulosis 13.09 11.21 7 183892 122 56108046
Axillary vein thrombosis 13.09 11.21 10 183889 330 56107838
Stenotrophomonas infection 13.08 11.21 22 183877 1759 56106409
Cytomegalovirus gastritis 13.07 11.21 8 183891 182 56107986
Pneumonia parainfluenzae viral 13.06 11.21 6 183893 74 56108094
Septic embolus 13.04 11.21 15 183884 838 56107330
Dermatomyositis 13.01 11.21 28 183871 2694 56105474
Glomerulonephritis membranoproliferative 12.99 11.21 8 183891 184 56107984
Facet joint syndrome 12.98 11.21 3 183896 6714 56101454
Haemolytic uraemic syndrome 12.95 11.21 26 183873 2382 56105786
Immunosuppression 12.95 11.21 56 183843 7908 56100260
Clonal haematopoiesis 12.94 11.21 4 183895 14 56108154
Back injury 12.94 11.21 5 183894 8021 56100147
Neutrophilia 12.92 11.21 35 183864 3898 56104270
Chronic hepatitis 12.91 11.21 15 183884 847 56107321
Tenosynovitis 12.87 11.21 13 183886 12448 56095720
Oligohydramnios 12.87 11.21 46 183853 5948 56102220
Increased tendency to bruise 12.87 11.21 8 183891 9770 56098398
Metapneumovirus infection 12.85 11.21 15 183884 851 56107317
Rectal fissure 12.83 11.21 12 183887 525 56107643
Body height decreased 12.82 11.21 7 183892 9178 56098990
Respiratory depression 12.81 11.21 13 183886 12422 56095746
Candida test positive 12.81 11.21 15 183884 854 56107314
Obstructive airways disorder 12.81 11.21 23 183876 17259 56090909
Full blood count abnormal 12.74 11.21 44 183855 26418 56081750
Hypersensitivity pneumonitis 12.73 11.21 26 183873 2411 56105757
Papillary thyroid cancer 12.72 11.21 24 183875 2100 56106068
Ovarian cyst 12.70 11.21 18 183881 14848 56093320
Evans syndrome 12.69 11.21 8 183891 192 56107976
Liver scan abnormal 12.67 11.21 5 183894 41 56108127
Chromaturia 12.66 11.21 19 183880 15306 56092862
Acute hepatitis C 12.65 11.21 6 183893 80 56108088
Pulmonary vascular disorder 12.61 11.21 10 183889 349 56107819
Malignant ascites 12.60 11.21 15 183884 869 56107299
Metastases to abdominal cavity 12.57 11.21 11 183888 441 56107727
Candida pneumonia 12.56 11.21 7 183892 133 56108035
Blindness 12.54 11.21 103 183796 18318 56089850
Bone sarcoma 12.52 11.21 4 183895 16 56108152
Beta 2 microglobulin decreased 12.52 11.21 4 183895 16 56108152
Infusion site eschar 12.52 11.21 4 183895 16 56108152
Hepatic candidiasis 12.52 11.21 4 183895 16 56108152
Ileus 12.52 11.21 83 183816 13799 56094369
Pulmonary vein stenosis 12.52 11.21 6 183893 82 56108086
Metastases to heart 12.52 11.21 6 183893 82 56108086
Sputum discoloured 12.52 11.21 17 183882 14275 56093893
Blood glucose abnormal 12.51 11.21 4 183895 7224 56100944
Angina pectoris 12.49 11.21 48 183851 27928 56080240
Platelet disorder 12.49 11.21 21 183878 1679 56106489
Oral fungal infection 12.44 11.21 27 183872 2613 56105555
Delusion 12.41 11.21 11 183888 11204 56096964
Skin fissures 12.37 11.21 8 183891 9565 56098603
Arteritis infective 12.37 11.21 5 183894 44 56108124
Skin haemorrhage 12.35 11.21 6 183893 8407 56099761
Tuberous sclerosis complex 12.33 11.21 6 183893 85 56108083
Ocular vasculitis 12.27 11.21 5 183894 45 56108123
Liver function test abnormal 12.25 11.21 93 183806 45578 56062590
Clostridium test positive 12.24 11.21 26 183873 2479 56105689
Laryngeal stenosis 12.21 11.21 15 183884 898 56107270
Chronic lymphocytic leukaemia refractory 12.17 11.21 5 183894 46 56108122
Anti-platelet antibody positive 12.17 11.21 5 183894 46 56108122
Venous haemorrhage 12.15 11.21 9 183890 283 56107885
Tongue disorder 12.15 11.21 9 183890 10027 56098141
Actinomycotic sepsis 12.14 11.21 6 183893 88 56108080
Hemianopia 12.12 11.21 16 183883 1030 56107138
Breast prosthesis removal 12.11 11.21 3 183896 3 56108165
Allogenic bone marrow transplantation therapy 12.11 11.21 3 183896 3 56108165
Sarcoma metastatic 12.11 11.21 3 183896 3 56108165
Li-Fraumeni syndrome 12.11 11.21 3 183896 3 56108165
Subretinal hyperreflective exudation 12.11 11.21 3 183896 3 56108165
Neuromuscular toxicity 12.11 11.21 7 183892 143 56108025
Acute cutaneous lupus erythematosus 12.10 11.21 9 183890 285 56107883
SARS-CoV-2 test negative 12.10 11.21 11 183888 464 56107704
Hydronephrosis 12.10 11.21 61 183838 9181 56098987
West Nile viral infection 12.08 11.21 10 183889 371 56107797
Leukostasis syndrome 12.08 11.21 5 183894 47 56108121
Enterovirus test positive 12.06 11.21 7 183892 144 56108024
Metastases to spleen 12.02 11.21 7 183892 145 56108023
Low cardiac output syndrome 12.02 11.21 9 183890 288 56107880
Culture stool positive 12.02 11.21 9 183890 288 56107880
Hodgkin's disease 12.00 11.21 14 183885 794 56107374
Frustration tolerance decreased 11.95 11.21 3 183896 6350 56101818
Steroid dependence 11.92 11.21 11 183888 473 56107695
Cytokine storm 11.91 11.21 9 183890 292 56107876
Dandy-Walker syndrome 11.91 11.21 6 183893 92 56108076
Hypercholesterolaemia 11.90 11.21 18 183881 14455 56093713
Extramedullary haemopoiesis 11.90 11.21 5 183894 49 56108119
Carotidynia 11.89 11.21 7 183892 148 56108020
Head discomfort 11.89 11.21 13 183886 12001 56096167
Metastases to ovary 11.86 11.21 10 183889 381 56107787
Large intestine perforation 11.85 11.21 54 183845 7797 56100371
Scintillating scotoma 11.85 11.21 7 183892 149 56108019
Pulmonary function test decreased 11.84 11.21 32 183867 3559 56104609
Lymphatic obstruction 11.81 11.21 4 183895 20 56108148
Malignant neoplasm of orbit 11.81 11.21 4 183895 20 56108148
Ureteritis 11.81 11.21 4 183895 20 56108148
Feeling cold 11.78 11.21 33 183866 21154 56087014
Bipolar disorder 11.76 11.21 5 183894 7575 56100593
Necrotising fasciitis 11.73 11.21 27 183872 2718 56105450
Scoliosis 11.72 11.21 4 183895 6929 56101239
Otitis media 11.71 11.21 38 183861 4678 56103490
Foot operation 11.71 11.21 3 183896 6264 56101904
Scar 11.71 11.21 14 183885 12419 56095749
Citrobacter infection 11.70 11.21 10 183889 388 56107780
Subacute combined cord degeneration 11.67 11.21 8 183891 222 56107946
Psychomotor hyperactivity 11.64 11.21 9 183890 9811 56098357
Tooth infection 11.64 11.21 21 183878 15731 56092437
Dysstasia 11.63 11.21 29 183870 19325 56088843
Electrocardiogram QT prolonged 11.61 11.21 118 183781 54470 56053698
Norovirus test positive 11.61 11.21 7 183892 155 56108013
Eating disorder 11.60 11.21 24 183875 17081 56091087
Quadriparesis 11.58 11.21 21 183878 1783 56106385
Monocyte count decreased 11.56 11.21 22 183877 1938 56106230
Osmotic demyelination syndrome 11.55 11.21 12 183887 597 56107571
Cytomegalovirus oesophagitis 11.55 11.21 8 183891 226 56107942
Rotavirus infection 11.55 11.21 9 183890 306 56107862
Eosinophilic fasciitis 11.53 11.21 7 183892 157 56108011
Hereditary motor and sensory neuropathy 11.51 11.21 6 183893 99 56108069
Cutaneous T-cell lymphoma 11.48 11.21 18 183881 1357 56106811
Gestational diabetes 11.47 11.21 6 183893 8058 56100110
Microangiopathy 11.47 11.21 16 183883 1086 56107082
Endocrine ophthalmopathy 11.47 11.21 11 183888 497 56107671
Gastric neoplasm 11.45 11.21 9 183890 310 56107858
Meningoencephalitis herpetic 11.44 11.21 16 183883 1088 56107080
Bicytopenia 11.43 11.21 23 183876 2110 56106058
Deformity 11.41 11.21 10 183889 10245 56097923
Bladder perforation 11.41 11.21 7 183892 160 56108008
Pericardial effusion malignant 11.41 11.21 6 183893 101 56108067
Stomatococcal infection 11.41 11.21 6 183893 101 56108067
Magnetic resonance imaging head abnormal 11.40 11.21 21 183878 1805 56106363
Pseudomyopia 11.39 11.21 5 183894 55 56108113
Herpes virus infection 11.38 11.21 40 183859 5130 56103038
Toothache 11.37 11.21 26 183873 17854 56090314
Kaposi's sarcoma 11.37 11.21 7 183892 161 56108007
Human chorionic gonadotropin increased 11.37 11.21 18 183881 1368 56106800
Blood creatine increased 11.37 11.21 40 183859 5133 56103035
Pulmonary haemosiderosis 11.35 11.21 4 183895 23 56108145
Cytomegalovirus urinary tract infection 11.35 11.21 4 183895 23 56108145
Corynebacterium sepsis 11.35 11.21 4 183895 23 56108145
Hysterectomy 11.35 11.21 7 183892 8584 56099584
Metastases to pancreas 11.34 11.21 8 183891 233 56107935
Coronavirus infection 11.32 11.21 30 183869 3299 56104869
Febrile convulsion 11.30 11.21 10 183889 407 56107761
Vaginal infection 11.30 11.21 4 183895 6773 56101395
Lymphocytic infiltration 11.27 11.21 14 183885 848 56107320
Mitral valve disease 11.27 11.21 24 183875 2293 56105875
Laboratory test abnormal 11.26 11.21 42 183857 24653 56083515
Follicle centre lymphoma, follicular grade I, II, III stage IV 11.26 11.21 3 183896 5 56108163
Micrococcus infection 11.23 11.21 5 183894 57 56108111
Skin abrasion 11.22 11.21 7 183892 8534 56099634
Dental caries 11.21 11.21 10 183889 10158 56098010
Tricuspid valve incompetence 11.21 11.21 78 183821 13175 56094993

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 4082.60 12.46 3891 149218 117958 31426277
Neutropenia 1449.85 12.46 2499 150610 137865 31406370
Cytokine release syndrome 1397.90 12.46 917 152192 15725 31528510
Product use in unapproved indication 1202.19 12.46 1899 151210 97272 31446963
Myelosuppression 908.30 12.46 675 152434 14245 31529990
Mucosal inflammation 813.36 12.46 915 152194 33512 31510723
Hypogammaglobulinaemia 793.25 12.46 458 152651 6169 31538066
Acute graft versus host disease 789.55 12.46 445 152664 5708 31538527
Bone marrow failure 754.94 12.46 798 152311 27210 31517025
Myelodysplastic syndrome 745.22 12.46 669 152440 18582 31525653
Cytomegalovirus infection 718.08 12.46 733 152376 23974 31520261
Off label use 706.70 12.46 3424 149685 343850 31200385
Hepatitis B 695.83 12.46 401 152708 5380 31538855
Progressive multifocal leukoencephalopathy 685.34 12.46 471 152638 8742 31535493
Cystitis haemorrhagic 669.12 12.46 379 152730 4910 31539325
Haematotoxicity 625.25 12.46 404 152705 6733 31537502
Diffuse large B-cell lymphoma recurrent 623.18 12.46 299 152810 2676 31541559
Diffuse large B-cell lymphoma 608.15 12.46 427 152682 8214 31536021
Pancytopenia 550.76 12.46 1267 151842 86049 31458186
Cytopenia 543.42 12.46 440 152669 10570 31533665
Chronic graft versus host disease 526.82 12.46 304 152805 4088 31540147
Graft versus host disease 525.15 12.46 422 152687 10025 31534210
Acute myeloid leukaemia 511.88 12.46 537 152572 18135 31526100
Disease progression 511.40 12.46 1258 151851 89206 31455029
Second primary malignancy 510.05 12.46 354 152755 6678 31537557
Pyrexia 508.01 12.46 2839 150270 301001 31243234
Venoocclusive liver disease 474.99 12.46 346 152763 7066 31537169
Acute graft versus host disease in skin 441.74 12.46 281 152828 4551 31539684
Hepatitis B reactivation 433.96 12.46 248 152861 3270 31540965
Thrombocytopenia 413.10 12.46 1569 151540 141178 31403057
Completed suicide 410.87 12.46 6 153103 91508 31452727
Tumour lysis syndrome 403.10 12.46 432 152677 14953 31529282
Fall 399.91 12.46 200 152909 185889 31358346
Neutrophil count decreased 396.86 12.46 763 152346 45631 31498604
Pneumocystis jirovecii pneumonia 395.21 12.46 464 152645 17787 31526448
Neurotoxicity 380.75 12.46 430 152679 15796 31528439
Posterior reversible encephalopathy syndrome 365.26 12.46 327 152782 9040 31535195
Product dose omission issue 351.66 12.46 47 153062 105539 31438696
Venoocclusive disease 347.49 12.46 195 152914 2477 31541758
Febrile bone marrow aplasia 338.25 12.46 290 152819 7556 31536679
Neutropenic sepsis 328.53 12.46 350 152759 12029 31532206
Plasma cell myeloma 322.11 12.46 789 152320 55742 31488493
Drug interaction 316.21 12.46 325 152784 208218 31336017
BK virus infection 313.26 12.46 232 152877 4863 31539372
Therapy partial responder 310.64 12.46 256 152853 6306 31537929
Arthralgia 310.04 12.46 173 152936 151251 31392984
Adenovirus infection 304.76 12.46 222 152887 4532 31539703
Epstein-Barr virus infection 303.82 12.46 259 152850 6694 31537541
Sepsis 302.40 12.46 1492 151617 150437 31393798
Dizziness 298.91 12.46 313 152796 198834 31345401
Haemophagocytic lymphohistiocytosis 297.29 12.46 323 152786 11355 31532880
Post transplant lymphoproliferative disorder 289.63 12.46 238 152871 5838 31538397
Acute lymphocytic leukaemia recurrent 283.92 12.46 182 152927 2988 31541247
Immune effector cell-associated neurotoxicity syndrome 266.83 12.46 160 152949 2319 31541916
Cytomegalovirus infection reactivation 266.78 12.46 190 152919 3739 31540496
Leukopenia 263.91 12.46 743 152366 57085 31487150
Septic shock 257.21 12.46 803 152306 65355 31478880
Myocardial infarction 255.65 12.46 114 152995 113340 31430895
White blood cell count decreased 248.50 12.46 956 152153 86442 31457793
Disease recurrence 245.72 12.46 372 152737 18289 31525946
Fatigue 244.74 12.46 818 152291 334388 31209847
Pain 242.33 12.46 329 152780 186430 31357805
Overdose 242.02 12.46 56 153053 84608 31459627
Graft versus host disease in skin 235.18 12.46 170 152939 3427 31540808
Dyspnoea 227.60 12.46 873 152236 342606 31201629
Anxiety 225.53 12.46 79 153030 90954 31453281
Aspergillus infection 224.85 12.46 278 152831 11250 31532985
Lymphopenia 224.21 12.46 310 152799 14019 31530216
Platelet count decreased 216.22 12.46 1080 152029 109355 31434880
Cardiotoxicity 213.00 12.46 184 152925 4843 31539392
Graft versus host disease in gastrointestinal tract 204.02 12.46 154 152955 3325 31540910
Rhabdomyolysis 200.75 12.46 33 153076 63548 31480687
Malaise 196.95 12.46 319 152790 168192 31376043
Rash 195.44 12.46 427 152682 201059 31343176
Thrombotic microangiopathy 194.55 12.46 233 152876 9118 31535117
Insomnia 194.44 12.46 108 153001 94728 31449507
Diffuse large B-cell lymphoma refractory 191.50 12.46 97 153012 986 31543249
Neoplasm progression 191.41 12.46 348 152761 19924 31524311
Multiple organ dysfunction syndrome 188.84 12.46 740 152369 67463 31476772
Cytomegalovirus chorioretinitis 188.41 12.46 146 152963 3282 31540953
Lymphadenopathy 183.34 12.46 396 152713 25725 31518510
Death 177.65 12.46 1020 152089 359549 31184686
Bronchopulmonary aspergillosis 175.54 12.46 269 152840 13365 31530870
Blood pressure increased 174.67 12.46 83 153026 79550 31464685
Depression 174.11 12.46 112 152997 90703 31453532
Psoriasis 172.90 12.46 14 153095 46705 31497530
Pruritus 171.99 12.46 211 152898 124956 31419279
Acquired gene mutation 170.74 12.46 96 153013 1224 31543011
Somnolence 168.13 12.46 140 152969 99305 31444930
Inappropriate schedule of product administration 159.05 12.46 27 153082 50796 31493439
B-cell lymphoma recurrent 155.87 12.46 73 153036 615 31543620
Muscle spasms 154.81 12.46 68 153041 68250 31475985
Feeling abnormal 152.67 12.46 43 153066 56959 31487276
Pain in extremity 152.26 12.46 203 152906 116000 31428235
Joint swelling 151.34 12.46 36 153073 53395 31490840
Suicide attempt 150.29 12.46 7 153102 37241 31506994
Acute lymphocytic leukaemia 149.90 12.46 129 152980 3377 31540858
Suicidal ideation 149.68 12.46 6 153103 36400 31507835
Respiratory failure 148.26 12.46 917 152192 100532 31443703
Infection 146.83 12.46 782 152327 81149 31463086
Malignant neoplasm progression 141.56 12.46 754 152355 78244 31465991
Peripheral swelling 140.93 12.46 76 153033 67789 31476446
Herpes simplex 140.38 12.46 149 152960 5096 31539139
Lymphocyte count decreased 140.29 12.46 309 152800 20340 31523895
Gait disturbance 138.66 12.46 103 153006 77392 31466843
Mantle cell lymphoma recurrent 138.51 12.46 62 153047 465 31543770
Aggression 138.47 12.46 11 153098 37280 31506955
Rheumatoid arthritis 137.81 12.46 31 153078 47778 31496457
Acute graft versus host disease in intestine 137.56 12.46 107 153002 2419 31541816
Cytomegalovirus viraemia 137.33 12.46 166 152943 6559 31537676
Intentional product misuse 136.01 12.46 13 153096 37938 31506297
Central nervous system lymphoma 135.31 12.46 78 153031 1046 31543189
JC virus infection 134.39 12.46 96 153013 1898 31542337
Chest pain 134.11 12.46 224 152885 116733 31427502
Blood glucose increased 131.90 12.46 65 153044 61018 31483217
Neuropathy peripheral 130.09 12.46 714 152395 74935 31469300
B-cell type acute leukaemia 129.91 12.46 52 153057 284 31543951
Coronary artery disease 128.66 12.46 32 153077 46055 31498180
Cerebrovascular accident 126.95 12.46 118 152991 79366 31464869
Weight increased 124.58 12.46 130 152979 82817 31461418
Viral haemorrhagic cystitis 122.66 12.46 71 153038 960 31543275
Hospitalisation 121.96 12.46 44 153065 49763 31494472
Musculoskeletal stiffness 120.72 12.46 26 153083 41299 31502936
Candida infection 120.44 12.46 252 152857 16006 31528229
Epstein-Barr virus associated lymphoproliferative disorder 119.54 12.46 86 153023 1720 31542515
Fungal infection 119.02 12.46 235 152874 14316 31529919
Drug resistance 118.51 12.46 313 152796 23140 31521095
Polyneuropathy 118.44 12.46 220 152889 12802 31531433
Neoplasm recurrence 118.28 12.46 91 153018 2023 31542212
Sweat gland tumour 117.43 12.46 52 153057 379 31543856
Stem cell transplant 116.43 12.46 89 153020 1959 31542276
Loss of consciousness 116.43 12.46 121 152988 77234 31467001
Asthenia 116.23 12.46 625 152484 224130 31320105
Injection site pain 116.19 12.46 15 153094 34619 31509616
Headache 115.95 12.46 475 152634 183177 31361058
Toxicity to various agents 114.20 12.46 470 152639 181017 31363218
Myalgia 112.76 12.46 124 152985 77134 31467101
Pseudomonas infection 111.79 12.46 199 152910 11202 31533033
Aplasia 111.77 12.46 119 152990 4084 31540151
Hyperhidrosis 110.05 12.46 98 153011 67295 31476940
Weight decreased 109.09 12.46 401 152708 159551 31384684
Hypoglycaemia 107.31 12.46 56 153053 50890 31493345
Systemic mycosis 107.07 12.46 74 153035 1385 31542850
Stress 106.44 12.46 3 153106 24938 31519297
End stage renal disease 105.79 12.46 161 152948 7948 31536287
Chronic lymphocytic leukaemia 105.13 12.46 123 152986 4693 31539542
Cystitis viral 104.33 12.46 51 153058 477 31543758
Nasopharyngitis 102.04 12.46 93 153016 63152 31481083
Engraftment syndrome 101.29 12.46 60 153049 849 31543386
Hallucination 100.77 12.46 49 153060 46361 31497874
Autoimmune haemolytic anaemia 100.28 12.46 112 152997 4060 31540175
Bacteraemia 100.17 12.46 246 152863 17388 31526847
Human herpesvirus 6 infection 98.20 12.46 79 153030 1878 31542357
Nausea 97.72 12.46 984 152125 306963 31237272
Drug hypersensitivity 96.90 12.46 125 152984 72474 31471761
Lymphoproliferative disorder 95.76 12.46 88 153021 2517 31541718
Incorrect dose administered 93.82 12.46 28 153081 35724 31508511
Wrong technique in product usage process 93.36 12.46 23 153086 33320 31510915
Loss of personal independence in daily activities 93.11 12.46 13 153096 28275 31515960
B-cell lymphoma 92.85 12.46 111 152998 4334 31539901
Diarrhoea 92.62 12.46 1175 151934 351234 31193001
Escherichia infection 92.45 12.46 143 152966 7161 31537074
Chronic obstructive pulmonary disease 91.69 12.46 52 153057 45114 31499121
Pneumonia cytomegaloviral 91.05 12.46 89 153020 2755 31541480
Back pain 90.86 12.46 251 152858 109162 31435073
Chronic lymphocytic leukaemia recurrent 90.84 12.46 43 153066 372 31543863
Chest discomfort 90.39 12.46 64 153045 49305 31494930
Abdominal discomfort 90.34 12.46 70 153039 51497 31492738
Blood creatine phosphokinase increased 90.09 12.46 45 153064 41929 31502306
Urticaria 89.93 12.46 87 153022 57430 31486805
Hepatic failure 89.75 12.46 354 152755 32348 31511887
Chronic graft versus host disease in skin 89.39 12.46 55 153054 837 31543398
Agranulocytosis 88.15 12.46 264 152845 20983 31523252
Asthma 88.03 12.46 48 153061 42563 31501672
Minimal residual disease 86.75 12.46 40 153069 324 31543911
Heart rate decreased 86.28 12.46 16 153093 28250 31515985
Cytomegalovirus test positive 85.32 12.46 96 153013 3509 31540726
Hyperkalaemia 84.64 12.46 112 152997 64239 31479996
Lymphoma 83.84 12.46 172 152937 10771 31533464
International normalised ratio increased 83.61 12.46 58 153051 45165 31499070
Confusional state 83.36 12.46 346 152763 132988 31411247
Bradycardia 82.95 12.46 129 152980 69198 31475037
Leukoencephalopathy 82.43 12.46 98 153011 3804 31540431
Bacterial sepsis 82.42 12.46 109 153000 4719 31539516
Escherichia sepsis 82.06 12.46 101 153008 4066 31540169
Cardiac failure congestive 82.04 12.46 162 152947 79225 31465010
Plasmacytoma 81.76 12.46 91 153018 3286 31540949
Transplant failure 80.47 12.46 87 153022 3039 31541196
Osteonecrosis 79.19 12.46 194 152915 13690 31530545
Klebsiella infection 78.82 12.46 138 152971 7665 31536570
Plasma cell myeloma recurrent 78.72 12.46 96 153013 3828 31540407
Sedation 78.38 12.46 3 153106 18962 31525273
Stomatitis 77.92 12.46 387 152722 39051 31505184
Infection reactivation 77.56 12.46 59 153050 1289 31542946
Mucormycosis 77.53 12.46 114 152995 5456 31538779
Syncope 77.16 12.46 187 152922 84995 31459240
Pneumonia 76.45 12.46 2139 150970 333173 31211062
Contusion 76.18 12.46 32 153077 32996 31511239
Acute graft versus host disease in liver 75.28 12.46 59 153050 1349 31542886
Therapy non-responder 74.94 12.46 343 152766 33468 31510767
Microsporidia infection 73.80 12.46 43 153066 589 31543646
Enterococcal infection 72.60 12.46 142 152967 8589 31535646
Pneumonia fungal 71.97 12.46 118 152991 6211 31538024
Graft versus host disease in liver 71.29 12.46 53 153056 1117 31543118
Arthropathy 70.50 12.46 15 153094 24036 31520199
Nephropathy toxic 69.44 12.46 163 152946 11190 31533045
Leukaemia recurrent 68.60 12.46 59 153050 1543 31542692
Agitation 68.49 12.46 97 153012 54072 31490163
Bacterial infection 68.02 12.46 182 152927 13557 31530678
Product prescribing error 67.12 12.46 8 153101 19634 31524601
Peripheral T-cell lymphoma unspecified 66.70 12.46 39 153070 538 31543697
Balance disorder 66.56 12.46 50 153059 37372 31506863
Accidental overdose 66.50 12.46 6 153103 18344 31525891
Injury 65.00 12.46 9 153100 19700 31524535
Tremor 64.39 12.46 174 152935 76246 31467989
Angioedema 63.64 12.46 42 153067 33576 31510659
Psoriatic arthropathy 63.44 12.46 10 153099 19873 31524362
Mobility decreased 62.73 12.46 27 153082 27442 31516793
Clostridium difficile colitis 62.46 12.46 179 152930 13877 31530358
Drug dependence 62.38 12.46 16 153093 22563 31521672
Abnormal behaviour 61.90 12.46 19 153090 23809 31520426
Staphylococcal bacteraemia 61.84 12.46 122 152987 7426 31536809
Aplastic anaemia 61.68 12.46 137 152972 9066 31535169
Dry skin 61.54 12.46 23 153086 25458 31518777
Cerebral toxoplasmosis 61.35 12.46 55 153054 1522 31542713
Cytogenetic abnormality 60.95 12.46 42 153067 782 31543453
Wheezing 60.34 12.46 51 153058 35935 31508300
Sleep disorder 60.01 12.46 26 153083 26322 31517913
Electrocardiogram QT prolonged 59.90 12.46 57 153052 37930 31506305
Chronic graft versus host disease in liver 59.48 12.46 31 153078 336 31543899
Plasmablastic lymphoma 59.35 12.46 29 153080 271 31543964
Pseudomonal sepsis 59 12.46 75 153034 3121 31541114
Staphylococcal sepsis 58.98 12.46 134 152975 9003 31535232
Anaplastic lymphoma kinase gene mutation 58.94 12.46 22 153087 96 31544139
Interstitial lung disease 58.90 12.46 502 152607 60901 31483334
Heart rate increased 58.84 12.46 67 153042 41043 31503192
Refractory cytopenia with multilineage dysplasia 58.63 12.46 23 153086 118 31544117
Blood stem cell transplant failure 58.44 12.46 32 153077 386 31543849
Nephrolithiasis 57.63 12.46 30 153079 27309 31516926
Neutropenic colitis 57.51 12.46 68 153041 2624 31541611
Drug ineffective for unapproved indication 57.49 12.46 203 152906 17587 31526648
Hypersensitivity 57.36 12.46 114 152995 55629 31488606
Osteosarcoma 57.27 12.46 28 153081 262 31543973
Cardiac disorder 57.12 12.46 63 153046 39151 31505084
Abdominal pain upper 56.77 12.46 142 152967 63860 31480375
Product quality issue 56.46 12.46 6 153103 16105 31528130
Treatment noncompliance 55.92 12.46 27 153082 25657 31518578
Psychotic disorder 55.75 12.46 19 153090 22274 31521961
Epstein-Barr virus infection reactivation 55.68 12.46 40 153069 798 31543437
Colitis ulcerative 55.46 12.46 11 153098 18518 31525717
Refractory anaemia with an excess of blasts 55.21 12.46 31 153078 394 31543841
Gastrooesophageal reflux disease 54.38 12.46 50 153059 33821 31510414
Hepatotoxicity 54.05 12.46 209 152900 18917 31525318
Neuroblastoma 53.95 12.46 26 153083 235 31544000
Flushing 53.91 12.46 40 153069 30088 31514147
Memory impairment 53.64 12.46 63 153046 38067 31506168
Myelopathy 53.50 12.46 60 153049 2185 31542050
Chloroma 53.47 12.46 33 153076 505 31543730
Constipation 53.34 12.46 365 152744 123626 31420609
Dehydration 53.06 12.46 347 152762 118764 31425471
Unevaluable event 52.91 12.46 42 153067 30533 31513702
Enterococcal bacteraemia 52.51 12.46 52 153057 1636 31542599
Erythema 52.50 12.46 205 152904 80200 31464035
Swelling 52.26 12.46 62 153047 37296 31506939
Encephalopathy 52.11 12.46 301 152808 32173 31512062
Primary amyloidosis 51.67 12.46 22 153087 144 31544091
Malignant transformation 51.19 12.46 38 153071 799 31543436
Plasma cell leukaemia 51.17 12.46 40 153069 911 31543324
Device related infection 50.97 12.46 184 152925 16115 31528120
Heart rate irregular 50.91 12.46 5 153104 14284 31529951
Enterovirus infection 50.73 12.46 36 153073 704 31543531
Bone marrow transplant rejection 50.66 12.46 23 153086 179 31544056
Fusarium infection 50.62 12.46 42 153067 1044 31543191
Rhinovirus infection 50.62 12.46 73 153036 3432 31540803
Recurrent cancer 50.58 12.46 44 153065 1169 31543066
Central nervous system fungal infection 50.55 12.46 28 153081 346 31543889
Strongyloidiasis 50.22 12.46 62 153047 2504 31541731
Klebsiella sepsis 50.17 12.46 53 153056 1802 31542433
Blood fibrinogen decreased 50.17 12.46 43 153066 1119 31543116
Blood lactate dehydrogenase increased 50.11 12.46 213 152896 20126 31524109
Toxoplasmosis 50.00 12.46 45 153064 1252 31542983
Lung infiltration 49.94 12.46 151 152958 12062 31532173
Respiratory arrest 49.43 12.46 33 153076 26224 31518011
Human polyomavirus infection 49.43 12.46 35 153074 682 31543553
Skin toxicity 49.27 12.46 79 153030 4080 31540155
Restlessness 48.70 12.46 26 153083 23335 31520900
Azoospermia 48.47 12.46 28 153081 377 31543858
Anaemia 48.17 12.46 1361 151748 212161 31332074
Primary hypogonadism 47.93 12.46 17 153092 62 31544173
Epstein-Barr viraemia 47.92 12.46 40 153069 1003 31543232
Disseminated intravascular coagulation 47.49 12.46 211 152898 20326 31523909
Oedema peripheral 46.91 12.46 324 152785 109515 31434720
Injection site erythema 46.77 12.46 7 153102 14455 31529780
Epstein-Barr virus associated lymphoma 46.74 12.46 33 153076 640 31543595
Blood pressure fluctuation 46.39 12.46 26 153083 22710 31521525
Herpes virus infection 45.91 12.46 60 153049 2567 31541668
Labelled drug-drug interaction medication error 45.88 12.46 5 153104 13158 31531077
Decreased appetite 45.79 12.46 496 152613 152721 31391514
Cardiac arrest 45.71 12.46 248 152861 88814 31455421
Hot flush 45.67 12.46 11 153098 16185 31528050
Treatment failure 45.36 12.46 345 152764 40447 31503788
B-cell aplasia 45.32 12.46 18 153091 96 31544139
Nervousness 45.17 12.46 3 153106 11797 31532438
Vertigo 44.84 12.46 28 153081 23057 31521178
Synovitis 44.55 12.46 4 153105 12279 31531956
Pneumonia klebsiella 44.18 12.46 62 153047 2842 31541393
Cardio-respiratory arrest 44.14 12.46 117 152992 51609 31492626
Pneumonitis 44.00 12.46 276 152833 30376 31513859
Depressed mood 43.91 12.46 15 153094 17560 31526675
Head injury 43.78 12.46 13 153096 16645 31527590
Nocardiosis 43.46 12.46 68 153041 3439 31540796
Varicella zoster virus infection 43.40 12.46 46 153063 1570 31542665
Candida sepsis 43.38 12.46 40 153069 1149 31543086
Osteoarthritis 43.13 12.46 19 153090 19048 31525187
Parainfluenzae virus infection 42.90 12.46 56 153053 2393 31541842
Staphylococcal infection 42.84 12.46 274 152835 30358 31513877
Adenoviral haemorrhagic cystitis 42.69 12.46 26 153083 388 31543847
Dyspepsia 42.44 12.46 57 153052 32496 31511739
Febrile infection 42.26 12.46 51 153058 2011 31542224
Pleural effusion 42.22 12.46 550 152559 74370 31469865
Anger 42.22 12.46 3 153106 11150 31533085
Cardiomyopathy 42.06 12.46 166 152943 15167 31529068
Liver function test abnormal 41.83 12.46 49 153060 29643 31514592
Polyomavirus viraemia 41.64 12.46 32 153077 710 31543525
Bone marrow necrosis 41.62 12.46 19 153090 150 31544085
Capillary leak syndrome 41.60 12.46 50 153059 1963 31542272
Blood pressure systolic increased 41.58 12.46 21 153088 19449 31524786
Lactic acidosis 41.55 12.46 56 153053 31881 31512354
Nightmare 41.33 12.46 5 153104 12132 31532103
Herpes zoster 41.01 12.46 280 152829 31713 31512522
Multiple sclerosis relapse 40.93 12.46 5 153104 12042 31532193
Road traffic accident 40.89 12.46 14 153095 16367 31527868
Therapeutic product effect decreased 40.58 12.46 56 153053 31566 31512669
Haematochezia 40.56 12.46 84 153025 40380 31503855
Respiratory tract infection fungal 40.45 12.46 31 153078 685 31543550
Blood glucose decreased 40.41 12.46 6 153103 12465 31531770
Irritability 40.16 12.46 31 153078 22858 31521377
Peripheral sensory neuropathy 40.08 12.46 92 153017 6223 31538012
Lymphoma transformation 39.88 12.46 19 153090 167 31544068
Acute myelomonocytic leukaemia 39.83 12.46 17 153092 112 31544123
Metabolic acidosis 39.80 12.46 82 153027 39495 31504740
Dyskinesia 39.74 12.46 26 153083 20884 31523351
Drug reaction with eosinophilia and systemic symptoms 39.70 12.46 52 153057 29966 31514269
Encephalitis 39.68 12.46 96 153013 6719 31537516
Faeces discoloured 39.59 12.46 9 153100 13777 31530458
Amnesia 39.43 12.46 33 153076 23369 31520866
Pulmonary toxicity 39.41 12.46 83 153026 5294 31538941
B-cell lymphoma refractory 39.33 12.46 18 153091 143 31544092
Peritonitis pneumococcal 39.32 12.46 12 153097 23 31544212
Diffuse large B-cell lymphoma stage IV 39.22 12.46 23 153086 319 31543916
Musculoskeletal pain 39.11 12.46 52 153057 29776 31514459
Gastrointestinal haemorrhage 39.05 12.46 236 152873 82313 31461922
Colitis 39.03 12.46 289 152820 33598 31510637
Neck pain 38.98 12.46 32 153077 22878 31521357
Palpitations 38.87 12.46 67 153042 34516 31509719
Adenovirus reactivation 38.84 12.46 19 153090 178 31544057
Surgery 38.73 12.46 7 153102 12592 31531643
Respiratory depression 38.73 12.46 11 153098 14499 31529736
Medication error 38.51 12.46 32 153077 22740 31521495
Delusion 38.35 12.46 6 153103 11991 31532244
Bone marrow infiltration 38.26 12.46 17 153092 125 31544110
Acute myocardial infarction 38.23 12.46 122 152987 50701 31493534
Autoimmune neutropenia 38.23 12.46 21 153088 255 31543980
Emotional distress 38.10 12.46 11 153098 14345 31529890
Drug ineffective 38.08 12.46 2302 150807 393271 31150964
Pneumocystis jirovecii infection 38.05 12.46 43 153066 1579 31542656
Influenza like illness 38.00 12.46 40 153069 25397 31518838
Granulomatosis with polyangiitis 38 12.46 36 153073 1071 31543164
5q minus syndrome 37.90 12.46 18 153091 157 31544078
Swollen tongue 37.74 12.46 8 153101 12854 31531381
Chronic myeloid leukaemia 37.69 12.46 56 153053 2705 31541530
Thymus enlargement 37.61 12.46 13 153096 43 31544192
Acute myeloid leukaemia recurrent 37.51 12.46 47 153062 1927 31542308
Myocardial ischaemia 37.08 12.46 17 153092 16650 31527585
Clear cell renal cell carcinoma 36.95 12.46 35 153074 1041 31543194
Oxygen saturation decreased 36.88 12.46 118 152991 48997 31495238
Paranoia 36.81 12.46 4 153105 10551 31533684
Flatulence 36.78 12.46 23 153086 18925 31525310
Prostatic specific antigen increased 36.63 12.46 10 153099 13528 31530707
Respiratory tract infection 36.59 12.46 175 152934 17386 31526849
Erectile dysfunction 36.44 12.46 24 153085 19211 31525024
Guillain-Barre syndrome 36.15 12.46 80 153029 5280 31538955
Complications of bone marrow transplant 36.06 12.46 19 153090 211 31544024
Coma 35.93 12.46 92 153017 41058 31503177
Polyomavirus-associated nephropathy 35.90 12.46 63 153046 3505 31540730
Clostridium difficile infection 35.86 12.46 172 152937 17107 31527128
Abdominal distension 35.84 12.46 125 152984 50559 31493676
Engraft failure 35.77 12.46 24 153085 427 31543808
Transient ischaemic attack 35.75 12.46 38 153071 24018 31520217
Hallucination, visual 35.31 12.46 16 153093 15778 31528457
Extrapyramidal disorder 35.23 12.46 7 153102 11771 31532464
Human herpesvirus 8 infection 35.22 12.46 31 153078 837 31543398
Gallbladder oedema 35.15 12.46 19 153090 223 31544012
Hepatosplenomegaly 35.08 12.46 66 153043 3877 31540358
Adverse drug reaction 35.06 12.46 42 153067 25159 31519076
Multiple-drug resistance 35.01 12.46 71 153038 4409 31539826
Diabetic ketoacidosis 34.97 12.46 19 153090 16886 31527349
B-lymphocyte count decreased 34.69 12.46 26 153083 555 31543680
Nodular regenerative hyperplasia 34.68 12.46 32 153077 920 31543315
Human herpesvirus 6 encephalitis 34.64 12.46 19 153090 230 31544005
Ventricular tachycardia 34.60 12.46 38 153071 23663 31520572
Anaplastic large-cell lymphoma 34.59 12.46 17 153092 161 31544074
Intestinal perforation 34.56 12.46 104 153005 8285 31535950
Amyloidosis 34.40 12.46 48 153061 2188 31542047
High-grade B-cell lymphoma 34.32 12.46 17 153092 164 31544071
Myeloid leukaemia 34.32 12.46 22 153087 361 31543874
Gene mutation 34.27 12.46 35 153074 1143 31543092
Refractory cancer 34.24 12.46 16 153093 134 31544101
Adverse event 34.23 12.46 19 153090 16686 31527549
Escherichia bacteraemia 34.19 12.46 56 153053 2945 31541290
Vision blurred 34.12 12.46 97 153012 41818 31502417
Therapy cessation 34.05 12.46 15 153094 15040 31529195
B precursor type acute leukaemia 34.01 12.46 19 153090 239 31543996
Myelitis transverse 33.96 12.46 33 153076 1014 31543221
Dysgeusia 33.84 12.46 38 153071 23428 31520807
Unresponsive to stimuli 33.81 12.46 45 153064 25755 31518480
Presyncope 33.68 12.46 21 153088 17307 31526928
Encephalitis enteroviral 33.55 12.46 16 153093 141 31544094
Pneumonia adenoviral 33.33 12.46 21 153088 334 31543901
Chronic lymphocytic leukaemia transformation 33.29 12.46 17 153092 176 31544059
Respirovirus test positive 33.25 12.46 13 153096 66 31544169
Meningoencephalitis herpetic 33.22 12.46 29 153080 774 31543461
Pulmonary vascular disorder 33.11 12.46 26 153083 596 31543639
Sleep apnoea syndrome 32.97 12.46 25 153084 18600 31525635
Burning sensation 32.96 12.46 20 153089 16727 31527508
B-lymphocyte count abnormal 32.84 12.46 9 153100 9 31544226
Skin discolouration 32.76 12.46 19 153090 16288 31527947
Anti-neutrophil cytoplasmic antibody positive vasculitis 32.67 12.46 29 153080 792 31543443
Gastritis bacterial 32.25 12.46 17 153092 189 31544046
Cholelithiasis 32.17 12.46 28 153081 19451 31524784
Delirium 32.17 12.46 98 153011 41323 31502912
Traumatic lung injury 32.16 12.46 34 153075 1157 31543078
Aphasia 32.13 12.46 185 152924 19746 31524489
Obliterative bronchiolitis 31.90 12.46 34 153075 1168 31543067
Fear 31.86 12.46 5 153104 9969 31534266
Out of specification test results 31.85 12.46 10 153099 22 31544213
T-cell lymphoma 31.78 12.46 31 153078 957 31543278
Pulmonary arteriopathy 31.75 12.46 13 153096 76 31544159
Chronic lymphocytic leukaemia refractory 31.62 12.46 14 153095 102 31544133
Graft versus host disease in eye 31.51 12.46 18 153091 237 31543998
Hypertriglyceridaemia 31.49 12.46 96 153013 7702 31536533
Type 2 diabetes mellitus 31.49 12.46 16 153093 14768 31529467
Acute lymphocytic leukaemia refractory 31.27 12.46 14 153095 105 31544130
Nervous system disorder 31.21 12.46 137 152972 13126 31531109
Paraparesis 31.18 12.46 41 153068 1765 31542470
Steroid diabetes 31.06 12.46 42 153067 1858 31542377
Glomerulonephritis rapidly progressive 31.06 12.46 24 153085 537 31543698
Stenotrophomonas infection 31.06 12.46 42 153067 1858 31542377
Gait inability 31.03 12.46 28 153081 19116 31525119
Gastrointestinal toxicity 30.87 12.46 46 153063 2228 31542007
Acute kidney injury 30.84 12.46 1074 152035 278640 31265595
Acute promyelocytic leukaemia 30.49 12.46 23 153086 496 31543739
Frequent bowel movements 30.47 12.46 6 153103 10153 31534082
Systemic candida 30.45 12.46 55 153054 3131 31541104
Pneumonia respiratory syncytial viral 30.43 12.46 28 153081 802 31543433
Acute monocytic leukaemia 30.39 12.46 20 153089 344 31543891
Sopor 30.39 12.46 9 153100 11543 31532692
Discomfort 30.19 12.46 21 153088 16335 31527900
Glioblastoma multiforme 30.18 12.46 27 153082 745 31543490
Meningitis cryptococcal 30.13 12.46 46 153063 2277 31541958
Rash pruritic 30.11 12.46 43 153066 23895 31520340
Congenital cardiovascular anomaly 29.96 12.46 16 153093 183 31544052
Enterococcal sepsis 29.93 12.46 37 153072 1496 31542739
Arthritis 29.92 12.46 54 153055 27331 31516904
Hypoxia 29.88 12.46 373 152736 49940 31494295
Ocular hyperaemia 29.83 12.46 6 153103 10003 31534232
Lower respiratory tract infection fungal 29.64 12.46 24 153085 576 31543659
Ependymoma 29.62 12.46 12 153097 68 31544167
Bone marrow disorder 29.58 12.46 38 153071 1598 31542637
Lentigo 29.56 12.46 20 153089 361 31543874
H1N1 influenza 29.39 12.46 29 153080 908 31543327
Encephalitis viral 29.36 12.46 32 153077 1128 31543107
Hypoaesthesia 29.28 12.46 155 152954 55867 31488368
Adult T-cell lymphoma/leukaemia 29.13 12.46 18 153091 276 31543959
Hypertensive crisis 29.08 12.46 3 153106 8244 31535991
Primitive neuroectodermal tumour 29.05 12.46 12 153097 72 31544163
Ototoxicity 28.95 12.46 39 153070 1719 31542516
Rectal haemorrhage 28.83 12.46 85 153024 36219 31508016
Limb discomfort 28.82 12.46 7 153102 10242 31533993
Humoral immune defect 28.78 12.46 12 153097 74 31544161
Acute erythroid leukaemia 28.75 12.46 15 153094 163 31544072
Hepatosplenic candidiasis 28.73 12.46 16 153093 200 31544035
Hypersomnia 28.64 12.46 9 153100 11110 31533125
Hypofibrinogenaemia 28.62 12.46 37 153072 1566 31542669
Therapy responder 28.59 12.46 15 153094 165 31544070
Aspiration bone marrow abnormal 28.54 12.46 13 153096 102 31544133
Prescribed overdose 28.49 12.46 5 153104 9187 31535048
Hyperlipidaemia 28.39 12.46 14 153095 13146 31531089
Blindness cortical 28.32 12.46 19 153090 338 31543897
T-cell lymphoma stage IV 28.27 12.46 14 153095 135 31544100
Eye pain 28.24 12.46 12 153097 12292 31531943
Therapeutic response decreased 28.24 12.46 222 152887 26287 31517948
Skin laceration 27.98 12.46 10 153099 11381 31532854
Dry mouth 27.84 12.46 47 153062 24411 31519824
Hypertension 27.84 12.46 443 152666 127657 31416578
Nasal cavity cancer 27.75 12.46 15 153094 176 31544059
Meningitis enteroviral 27.73 12.46 9 153100 23 31544212
Organic brain syndrome 27.61 12.46 17 153092 259 31543976
Glycosylated haemoglobin increased 27.54 12.46 8 153101 10392 31533843
Mass 27.53 12.46 88 153021 7243 31536992
Acute respiratory distress syndrome 27.53 12.46 208 152901 24332 31519903
Wound 27.52 12.46 14 153095 12914 31531321
Gastrosplenic fistula 27.46 12.46 9 153100 24 31544211
Molluscum contagiosum 27.44 12.46 17 153092 262 31543973
Transformation to acute myeloid leukaemia 27.41 12.46 25 153084 708 31543527
Immunosuppression 27.34 12.46 74 153035 5549 31538686
Feeling hot 27.21 12.46 23 153086 16210 31528025
Platelet transfusion 27.17 12.46 33 153076 1310 31542925
Herpes simplex encephalitis 27.13 12.46 18 153091 314 31543921
Coronary artery stenosis 27.11 12.46 5 153104 8865 31535370
Iron deficiency anaemia 27.10 12.46 6 153103 9353 31534882
Lymphoplasmacytoid lymphoma/immunocytoma 27.09 12.46 10 153099 42 31544193
Neuroblastoma recurrent 27.03 12.46 12 153097 88 31544147
Pneumomediastinum 26.97 12.46 42 153067 2115 31542120
Autoimmune lymphoproliferative syndrome 26.84 12.46 14 153095 152 31544083
Dystonia 26.83 12.46 8 153101 10217 31534018
Psychomotor hyperactivity 26.76 12.46 5 153104 8782 31535453
Fungal sepsis 26.75 12.46 26 153083 799 31543436
Dyspnoea exertional 26.64 12.46 97 153012 38740 31505495
Adenoviral hepatitis 26.58 12.46 21 153088 486 31543749
Haemorrhage 26.42 12.46 128 152981 47206 31497029
Panic attack 26.40 12.46 5 153104 8698 31535537
Melaena 26.26 12.46 76 153033 32578 31511657
Streptococcal infection 26.23 12.46 64 153045 4503 31539732
Haematopoietic stem cell mobilisation 26.15 12.46 14 153095 161 31544074
Cerebral aspergillosis 26.11 12.46 33 153076 1365 31542870
Limb injury 26.09 12.46 8 153101 10033 31534202
Graft versus host disease in lung 26.07 12.46 21 153088 500 31543735
Peripheral motor neuropathy 26.02 12.46 37 153072 1717 31542518
Joint stiffness 26.01 12.46 8 153101 10013 31534222
Juvenile melanoma benign 25.96 12.46 11 153098 71 31544164
Prostate cancer 25.74 12.46 94 153015 37507 31506728
Mantle cell lymphoma 25.73 12.46 37 153072 1735 31542500
Glioma 25.63 12.46 18 153091 346 31543889
COVID-19 pneumonia 25.56 12.46 125 152984 12530 31531705
Pneumonia viral 25.55 12.46 48 153061 2816 31541419
Granulocyte count decreased 25.49 12.46 23 153086 642 31543593
Metastasis 25.48 12.46 55 153054 3569 31540666
Metastases to spleen 25.41 12.46 19 153090 404 31543831
Peripheral T-cell lymphoma unspecified stage IV 25.34 12.46 9 153100 33 31544202
Viral sinusitis 25.33 12.46 11 153098 76 31544159
Burkitt's lymphoma 25.26 12.46 13 153096 137 31544098
Thrombosis 25.25 12.46 122 152987 45029 31499206
Stenotrophomonas sepsis 25.14 12.46 12 153097 106 31544129
Central nervous system leukaemia 25.09 12.46 16 153093 260 31543975
West Nile viral infection 25.05 12.46 23 153086 657 31543578
Ageusia 25.04 12.46 7 153102 9324 31534911
Cytomegalovirus colitis 25.02 12.46 45 153064 2553 31541682
Neoplasm 25.01 12.46 63 153046 4523 31539712
Human herpesvirus 6 infection reactivation 24.94 12.46 13 153096 141 31544094
Lethargy 24.90 12.46 99 153010 38542 31505693
Mood altered 24.88 12.46 5 153104 8341 31535894
Haematocrit decreased 24.84 12.46 238 152871 29823 31514412
Secondary immunodeficiency 24.80 12.46 18 153091 365 31543870
Hepatic infection fungal 24.79 12.46 14 153095 180 31544055
Hip fracture 24.76 12.46 11 153098 10975 31533260
Akathisia 24.67 12.46 3 153106 7250 31536985
Splenic candidiasis 24.63 12.46 11 153098 82 31544153
Neurofibrosarcoma 24.54 12.46 9 153100 37 31544198
Achromobacter infection 24.49 12.46 10 153099 58 31544177
T-cell type acute leukaemia 24.46 12.46 14 153095 185 31544050
Hepatitis viral 24.45 12.46 21 153088 548 31543687
Hyponatraemia 24.45 12.46 233 152876 73566 31470669
Meningeal neoplasm 24.35 12.46 10 153099 59 31544176
Neutropenic infection 24.31 12.46 31 153078 1294 31542941
Pulmonary alveolar haemorrhage 24.31 12.46 80 153029 6686 31537549
Poisoning 24.07 12.46 10 153099 10381 31533854
Encephalitis cytomegalovirus 23.94 12.46 20 153089 502 31543733
Paresis 23.89 12.46 38 153071 1949 31542286
Product storage error 23.84 12.46 3 153106 7063 31537172
Therapeutic response unexpected 23.79 12.46 7 153102 9017 31535218
Muscle rigidity 23.78 12.46 9 153100 9888 31534347
Oroantral fistula 23.76 12.46 14 153095 196 31544039
Eating disorder 23.71 12.46 4 153105 7565 31536670
Blood cholesterol increased 23.66 12.46 28 153081 16865 31527370
Accidental exposure to product 23.66 12.46 13 153096 11482 31532753
Eye disorder 23.53 12.46 6 153103 8496 31535739
Swelling face 23.53 12.46 42 153067 21348 31522887
Underdose 23.52 12.46 16 153093 12591 31531644
Salivary gland cancer 23.49 12.46 16 153093 292 31543943
Pulmonary veno-occlusive disease 23.46 12.46 19 153090 456 31543779
Chromaturia 23.34 12.46 18 153091 13280 31530955
Therapy interrupted 23.28 12.46 11 153098 10585 31533650
Precursor T-lymphoblastic lymphoma/leukaemia 23.16 12.46 10 153099 68 31544167
Serum ferritin increased 23.11 12.46 71 153038 5721 31538514
Stevens-Johnson syndrome 23.07 12.46 30 153079 17342 31526893
Carbohydrate antigen 15-3 increased 23.04 12.46 10 153099 69 31544166
Antithrombin III decreased 23.03 12.46 16 153093 302 31543933
Disturbance in attention 23.01 12.46 46 153063 22404 31521831
Device malfunction 22.99 12.46 8 153101 9258 31534977
Blood pressure decreased 22.99 12.46 137 152972 47954 31496281
Blood urea increased 22.98 12.46 68 153041 28944 31515291
Blood culture positive 22.85 12.46 61 153048 4537 31539698
Spermatozoa abnormal 22.81 12.46 9 153100 47 31544188
Leukaemia cutis 22.80 12.46 10 153099 71 31544164
Metastases to skin 22.80 12.46 18 153091 416 31543819
Diffuse large B-cell lymphoma stage III 22.68 12.46 10 153099 72 31544163
Diabetes mellitus inadequate control 22.68 12.46 17 153092 12724 31531511
Schizophrenia 22.65 12.46 12 153097 10818 31533417
Alpha haemolytic streptococcal infection 22.61 12.46 25 153084 896 31543339
Pemphigoid 22.58 12.46 6 153103 8265 31535970
Human metapneumovirus test positive 22.57 12.46 10 153099 73 31544162
Pericarditis 22.51 12.46 97 153012 9219 31535016
Hepatic enzyme increased 22.50 12.46 93 153016 35815 31508420
Viral load increased 22.48 12.46 39 153070 2150 31542085
Hernia 22.42 12.46 7 153102 8677 31535558
Enterovesical fistula 22.19 12.46 22 153087 693 31543542
Cellulitis gangrenous 22.19 12.46 13 153096 180 31544055
Pathogen resistance 22.11 12.46 92 153017 8609 31535626
Escherichia test positive 22.03 12.46 27 153082 1082 31543153
Tidal volume decreased 21.98 12.46 8 153101 32 31544203
Rotavirus infection 21.94 12.46 17 153092 382 31543853
Tendonitis 21.91 12.46 7 153102 8551 31535684
Movement disorder 21.91 12.46 13 153096 11006 31533229
Post-depletion B-cell recovery 21.90 12.46 6 153103 6 31544229
Metastases to bone marrow 21.83 12.46 19 153090 505 31543730
Mucoepidermoid carcinoma 21.82 12.46 7 153102 17 31544218
Sarcoma metastatic 21.79 12.46 10 153099 80 31544155
Pneumaturia 21.79 12.46 8 153101 33 31544202
Hepatic candidiasis 21.79 12.46 9 153100 54 31544181
Adenocarcinoma gastric 21.75 12.46 28 153081 1180 31543055
Cough 21.64 12.46 491 152618 134323 31409912
Electrocardiogram abnormal 21.62 12.46 6 153103 8030 31536205
Follicular lymphoma 21.55 12.46 12 153097 150 31544085
Blood pressure diastolic decreased 21.52 12.46 6 153103 8007 31536228
Viral test positive 21.52 12.46 13 153096 191 31544044
Capnocytophaga infection 21.52 12.46 9 153100 56 31544179
Chronic myelomonocytic leukaemia 21.48 12.46 21 153088 650 31543585
Gastrointestinal wall thickening 21.43 12.46 30 153079 1372 31542863
Illness 21.37 12.46 9 153100 9268 31534967
Central nervous system vasculitis 21.27 12.46 18 153091 460 31543775
Dysphonia 21.26 12.46 42 153067 20549 31523686
Cardiogenic shock 21.22 12.46 48 153061 22360 31521875
Eczema 21.12 12.46 26 153083 15391 31528844
Splenomegaly 21.11 12.46 126 152983 13623 31530612
Enterobacter infection 21.05 12.46 38 153071 2162 31542073
Gastric disorder 21.02 12.46 15 153094 11513 31532722
Mood swings 21.01 12.46 5 153104 7419 31536816
Chronic kidney disease 21.01 12.46 103 153006 37872 31506363
Basophilia 20.98 12.46 6 153103 8 31544227
Rhabdomyosarcoma recurrent 20.98 12.46 10 153099 88 31544147
Coronary artery occlusion 20.90 12.46 12 153097 10344 31533891
Haemoglobin abnormal 20.85 12.46 49 153060 3366 31540869
Abdominal pain 20.84 12.46 541 152568 145411 31398824
Respiratory tract infection viral 20.84 12.46 36 153073 1978 31542257
Disseminated cytomegaloviral infection 20.73 12.46 13 153096 205 31544030
Pneumonia mycoplasmal 20.59 12.46 20 153089 614 31543621
Evans syndrome 20.35 12.46 14 153095 260 31543975
Blood loss anaemia 20.33 12.46 6 153103 7713 31536522
Scedosporium infection 20.30 12.46 23 153086 847 31543388
Pneumatosis intestinalis 20.26 12.46 51 153058 3660 31540575
Urinary tract infection 20.16 12.46 256 152853 76613 31467622
Dementia 20.13 12.46 18 153091 12342 31531893
Splenic marginal zone lymphoma 20.09 12.46 8 153101 43 31544192
Haemolytic uraemic syndrome 20.07 12.46 36 153073 2038 31542197
Glomerulosclerosis 20.00 12.46 21 153088 709 31543526
Facial paresis 19.94 12.46 42 153067 2679 31541556
Viraemia 19.94 12.46 26 153083 1110 31543125
Lip swelling 19.84 12.46 21 153088 13302 31530933
Human rhinovirus test positive 19.83 12.46 12 153097 177 31544058
Arteriosclerosis 19.64 12.46 14 153095 10753 31533482
Bordetella infection 19.63 12.46 10 153099 103 31544132
Visual impairment 19.61 12.46 81 153028 31198 31513037
Product administration error 19.56 12.46 27 153082 15220 31529015
Ileus paralytic 19.48 12.46 64 153045 5344 31538891
Exophthalmos 19.44 12.46 18 153091 520 31543715
Condition aggravated 19.37 12.46 624 152485 163385 31380850
Small intestinal perforation 19.32 12.46 35 153074 1997 31542238
Infection in an immunocompromised host 19.31 12.46 19 153090 593 31543642
Inflammatory pseudotumour 19.23 12.46 7 153102 28 31544207
Papilloma viral infection 19.13 12.46 17 153092 465 31543770
Clostridium colitis 19.13 12.46 26 153083 1156 31543079
Diaphragm muscle weakness 19.11 12.46 11 153098 147 31544088
Tooth deposit 19.10 12.46 9 153100 77 31544158
Hyperbilirubinaemia 19.09 12.46 136 152973 15614 31528621
Delayed engraftment 19.06 12.46 10 153099 110 31544125
Herpes oesophagitis 18.98 12.46 11 153098 149 31544086
Subdural hygroma 18.96 12.46 14 153095 292 31543943
Polyomavirus test positive 18.90 12.46 10 153099 112 31544123
Adenocarcinoma of colon 18.88 12.46 46 153063 3234 31541001
Tooth development disorder 18.87 12.46 6 153103 14 31544221
Mucosal toxicity 18.87 12.46 13 153096 242 31543993
Mononeuropathy multiplex 18.80 12.46 11 153098 152 31544083
Focal nodular hyperplasia 18.80 12.46 11 153098 152 31544083
Orthostatic hypotension 18.77 12.46 57 153052 24062 31520173
Respiratory distress 18.75 12.46 246 152863 33307 31510928
Ischaemic cardiomyopathy 18.73 12.46 3 153106 5894 31538341
Restless legs syndrome 18.73 12.46 7 153102 7749 31536486
Intestinal atresia 18.71 12.46 9 153100 81 31544154
Hyperpyrexia 18.70 12.46 38 153071 2363 31541872
Periorbital infection 18.68 12.46 10 153099 115 31544120
Miosis 18.67 12.46 9 153100 8561 31535674
Bronchitis 18.66 12.46 110 152999 38607 31505628
Neutrophil count abnormal 18.64 12.46 31 153078 1651 31542584
Localised infection 18.63 12.46 28 153081 15237 31528998
Uveitis 18.50 12.46 5 153104 6811 31537424
Viral cardiomyopathy 18.50 12.46 7 153102 32 31544203
Abdominal lymphadenopathy 18.39 12.46 21 153088 780 31543455
Enterobacter sepsis 18.37 12.46 21 153088 781 31543454
Blood creatinine increased 18.36 12.46 311 152798 88767 31455468
Hepatitis D 18.32 12.46 7 153102 33 31544202
Cystitis escherichia 18.31 12.46 11 153098 160 31544075
Skin exfoliation 18.17 12.46 57 153052 23817 31520418
Blood HIV RNA increased 18.14 12.46 25 153084 1126 31543109
Actinomycosis 18.14 12.46 15 153094 371 31543864
Enteropathy-associated T-cell lymphoma 18.05 12.46 6 153103 17 31544218
Inhibin B 18.05 12.46 6 153103 17 31544218
Lung opacity 18.01 12.46 30 153079 1600 31542635
Retinal haemorrhage 17.96 12.46 57 153052 4673 31539562
Thirst 17.93 12.46 5 153104 6671 31537564
Left ventricular dysfunction 17.89 12.46 91 153018 9266 31534969
Disorientation 17.82 12.46 82 153027 30662 31513573
Device related thrombosis 17.82 12.46 23 153086 972 31543263
Metastases to retroperitoneum 17.81 12.46 12 153097 215 31544020
Rubulavirus test positive 17.78 12.46 5 153104 6 31544229
Hepatic amoebiasis 17.76 12.46 8 153101 61 31544174
Drug level increased 17.72 12.46 45 153064 20141 31524094
Inflammatory myofibroblastic tumour 17.68 12.46 10 153099 129 31544106
Disorder of orbit 17.64 12.46 9 153100 93 31544142
Leukaemia 17.63 12.46 51 153058 3974 31540261
Desmoid tumour 17.61 12.46 10 153099 130 31544105
Epistaxis 17.60 12.46 170 152939 53537 31490698
Diffuse large B-cell lymphoma stage II 17.52 12.46 7 153102 38 31544197
Acne 17.52 12.46 14 153095 10146 31534089
Ameloblastoma 17.47 12.46 9 153100 95 31544140
Nasal congestion 17.46 12.46 46 153063 20335 31523900
Fungal oesophagitis 17.36 12.46 14 153095 334 31543901
Adenoviral upper respiratory infection 17.35 12.46 4 153105 0 31544235
Salivary hypersecretion 17.25 12.46 8 153101 7784 31536451
Intussusception 17.24 12.46 17 153092 532 31543703
Metastases to meninges 17.24 12.46 26 153083 1273 31542962
Medulloblastoma recurrent 17.22 12.46 8 153101 66 31544169
Pleural mass 17.22 12.46 8 153101 66 31544169
Drug eruption 17.19 12.46 39 153070 18148 31526087
Pneumonia aspiration 17.12 12.46 113 152996 38613 31505622
Blastic plasmacytoid dendritic cell neoplasia 17.08 12.46 9 153100 100 31544135
Left ventricular hypertrophy 17.07 12.46 7 153102 7325 31536910
Skin mass 17.01 12.46 47 153062 3567 31540668
Drug level decreased 17.00 12.46 6 153103 6884 31537351
Positron emission tomogram abnormal 16.97 12.46 10 153099 140 31544095
Fluid retention 16.97 12.46 62 153047 24740 31519495
Personality change due to a general medical condition 16.95 12.46 7 153102 42 31544193
Rash macular 16.93 12.46 18 153091 11377 31532858
Medulloblastoma 16.92 12.46 8 153101 69 31544166
Hypokinesia 16.87 12.46 9 153100 8083 31536152
Drug clearance decreased 16.86 12.46 29 153080 1588 31542647
Pneumonia parainfluenzae viral 16.85 12.46 10 153099 142 31544093
Spinal column injury 16.83 12.46 17 153092 548 31543687
Peroneal nerve palsy 16.83 12.46 40 153069 2768 31541467
Viral vasculitis 16.82 12.46 8 153101 70 31544165
Post-acute COVID-19 syndrome 16.82 12.46 8 153101 70 31544165
POEMS syndrome 16.81 12.46 7 153102 43 31544192
Central nervous system enteroviral infection 16.81 12.46 7 153102 43 31544192
Metapneumovirus infection 16.78 12.46 18 153091 623 31543612
Acute polyneuropathy 16.73 12.46 10 153099 144 31544091
Retroperitoneal mass 16.72 12.46 8 153101 71 31544164
Helicobacter sepsis 16.68 12.46 6 153103 23 31544212
Haemolysis 16.57 12.46 74 153035 7142 31537093
Suspected product quality issue 16.55 12.46 10 153099 147 31544088
Sphingomonas paucimobilis infection 16.54 12.46 7 153102 45 31544190
Acute lung injury 16.53 12.46 26 153083 1321 31542914
Sinusitis bacterial 16.41 12.46 14 153095 362 31543873
Therapeutic response shortened 16.39 12.46 4 153105 5833 31538402
Neurological decompensation 16.37 12.46 38 153071 2589 31541646
Acanthamoeba infection 16.32 12.46 15 153094 429 31543806
Hepatomegaly 16.29 12.46 90 153019 9460 31534775
Refractory cytopenia with unilineage dysplasia 16.16 12.46 16 153093 503 31543732
Ventricular extrasystoles 16.11 12.46 18 153091 11124 31533111
Non-Hodgkin's lymphoma 16.09 12.46 28 153081 1547 31542688
Haematoma 16.09 12.46 61 153048 24078 31520157
Epstein-Barr virus test positive 16.04 12.46 16 153093 508 31543727
Diverticulitis 16.03 12.46 42 153067 18603 31525632
Candida pneumonia 16.02 12.46 13 153096 313 31543922
Kidney fibrosis 15.97 12.46 33 153076 2077 31542158
Emotional disorder 15.95 12.46 3 153106 5246 31538989
Blister 15.92 12.46 50 153059 20886 31523349
Chylothorax 15.91 12.46 18 153091 662 31543573
Ejection fraction decreased 15.90 12.46 141 152968 17293 31526942
Musculoskeletal discomfort 15.88 12.46 7 153102 7016 31537219
Candida endophthalmitis 15.85 12.46 9 153100 117 31544118
Retching 15.84 12.46 5 153104 6156 31538079
Vascular access complication 15.81 12.46 13 153096 319 31543916
Hepatitis B DNA increased 15.81 12.46 16 153093 517 31543718
Morphoea 15.76 12.46 10 153099 161 31544074
Haematemesis 15.73 12.46 67 153042 25586 31518649
Campylobacter infection 15.72 12.46 20 153089 833 31543402
Hyperthyroidism 15.71 12.46 14 153095 9617 31534618
Metastases to muscle 15.59 12.46 11 153098 213 31544022
Phlebitis infective 15.59 12.46 9 153100 121 31544114
Marginal zone lymphoma recurrent 15.59 12.46 6 153103 29 31544206
Cerebral salt-wasting syndrome 15.58 12.46 7 153102 53 31544182
Diabetes mellitus 15.56 12.46 131 152978 42425 31501810
Pseudomonal bacteraemia 15.54 12.46 24 153085 1200 31543035
Migraine 15.45 12.46 28 153081 14152 31530083
Diverticulum 15.45 12.46 6 153103 6488 31537747
Tricuspid valve incompetence 15.43 12.46 12 153097 8817 31535418
Blood bilirubin increased 15.42 12.46 247 152862 34889 31509346
Urinary bladder rupture 15.41 12.46 8 153101 86 31544149
Autonomic neuropathy 15.35 12.46 20 153089 853 31543382
Pulmonary haemorrhage 15.34 12.46 89 153020 9526 31534709
Kidney transplant rejection 15.33 12.46 8 153101 7274 31536961
Respiratory syncytial virus infection 15.32 12.46 47 153062 3784 31540451
Thinking abnormal 15.30 12.46 4 153105 5569 31538666
CSF protein increased 15.28 12.46 19 153090 773 31543462
Splenic lesion 15.28 12.46 9 153100 126 31544109
Multiple sclerosis 15.26 12.46 10 153099 8027 31536208
Testicular disorder 15.22 12.46 17 153092 616 31543619
Cytokine storm 15.20 12.46 17 153092 617 31543618
Pneumococcal infection 15.16 12.46 14 153095 403 31543832
Leukaemic infiltration 15.15 12.46 9 153100 128 31544107
Infusion site discolouration 15.15 12.46 9 153100 128 31544107
Citrobacter sepsis 15.15 12.46 7 153102 57 31544178
Herpes zoster infection neurological 15.13 12.46 4 153105 3 31544232
Autoimmune pancytopenia 15.09 12.46 8 153101 90 31544145
Atypical teratoid/rhabdoid tumour of CNS 15.08 12.46 5 153104 14 31544221
Cardiac dysfunction 14.95 12.46 31 153078 1956 31542279
Body temperature decreased 14.94 12.46 21 153088 11749 31532486
Blast cells present 14.91 12.46 15 153094 481 31543754
Device occlusion 14.90 12.46 5 153104 5920 31538315
Cardiac murmur 14.88 12.46 7 153102 6755 31537480
Gallbladder adenocarcinoma 14.83 12.46 5 153104 15 31544220
Gout 14.83 12.46 42 153067 18132 31526103
Prescribed underdose 14.79 12.46 11 153098 8267 31535968
Endocarditis bacterial 14.79 12.46 20 153089 885 31543350
Rib fracture 14.78 12.46 26 153083 13290 31530945
Cancer fatigue 14.74 12.46 7 153102 61 31544174
Bone marrow transplant 14.73 12.46 21 153088 977 31543258
Cryptococcal fungaemia 14.72 12.46 8 153101 95 31544140
Cerebral infarction 14.63 12.46 70 153039 25907 31518328
Secretion discharge 14.63 12.46 3 153106 4934 31539301
Lymphocytosis 14.61 12.46 32 153077 2097 31542138
Paraesthesia 14.60 12.46 187 152922 55884 31488351
Paraneoplastic pemphigus 14.55 12.46 7 153102 63 31544172
Chronic graft versus host disease in intestine 14.55 12.46 11 153098 238 31543997
Vomiting 14.54 12.46 910 152199 223063 31321172
Pulmonary oedema 14.52 12.46 141 152968 44361 31499874
Intentional product use issue 14.46 12.46 326 152783 49021 31495214
Rhabdomyosarcoma 14.46 12.46 7 153102 64 31544171
Blood potassium increased 14.42 12.46 33 153076 15312 31528923
Double hit lymphoma 14.39 12.46 6 153103 37 31544198
Gastric stenosis 14.39 12.46 6 153103 37 31544198
Palatal ulcer 14.39 12.46 6 153103 37 31544198
Disease susceptibility 14.36 12.46 7 153102 65 31544170
Meningitis tuberculous 14.35 12.46 17 153092 657 31543578
Abdominal wall abscess 14.34 12.46 15 153094 504 31543731
Hepatic cancer 14.33 12.46 10 153099 7765 31536470
Ill-defined disorder 14.33 12.46 107 153002 12470 31531765
Peripheral arterial occlusive disease 14.31 12.46 4 153105 5329 31538906
Combined immunodeficiency 14.27 12.46 7 153102 66 31544169
Anaphylactic reaction 14.22 12.46 84 153025 29469 31514766
Eye swelling 14.19 12.46 14 153095 9162 31535073
Tongue fungal infection 14.13 12.46 6 153103 39 31544196
Gynaecomastia 14.12 12.46 14 153095 9140 31535095
Urinary retention 14.12 12.46 100 153009 33625 31510610
VIth nerve paralysis 14.10 12.46 18 153091 752 31543483
Peritoneal lesion 14.09 12.46 8 153101 104 31544131
Hiatus hernia 14.09 12.46 8 153101 6939 31537296
Skin abrasion 14.09 12.46 7 153102 6544 31537691
Pulmonary mucormycosis 14.07 12.46 17 153092 671 31543564
Pericardial effusion 14.07 12.46 168 152941 22255 31521980
Blood urine present 14.05 12.46 17 153092 10140 31534095
Pulmonary hypoplasia 14.04 12.46 14 153095 444 31543791
Cutaneous T-cell lymphoma recurrent 14.00 12.46 6 153103 40 31544195
Post lumbar puncture syndrome 13.94 12.46 10 153099 199 31544036
Enterocolitis infectious 13.94 12.46 25 153084 1415 31542820
Microangiopathy 13.94 12.46 19 153090 847 31543388
Follicular mucinosis 13.94 12.46 5 153104 19 31544216
Glottis carcinoma 13.94 12.46 5 153104 19 31544216
Product use issue 13.93 12.46 366 152743 56393 31487842
Abdominal neoplasm 13.90 12.46 10 153099 200 31544035
Bladder hypertrophy 13.89 12.46 16 153093 600 31543635
Streptococcal bacteraemia 13.88 12.46 28 153081 1732 31542503
Cyanosis 13.87 12.46 22 153087 11713 31532522
Angina pectoris 13.87 12.46 85 153024 29556 31514679
Blindness 13.86 12.46 106 153003 12445 31531790
Vascular injury 13.83 12.46 11 153098 257 31543978
Cord blood transplant therapy 13.75 12.46 6 153103 42 31544193
Intraocular pressure increased 13.72 12.46 4 153105 5183 31539052
Cytomegalovirus enteritis 13.71 12.46 14 153095 457 31543778
Central nervous system mass 13.70 12.46 8 153101 110 31544125
Incorrect route of product administration 13.68 12.46 22 153087 11651 31532584
Renal amyloidosis 13.66 12.46 7 153102 73 31544162
Pulmonary sarcoidosis 13.64 12.46 15 153094 534 31543701
Crying 13.60 12.46 5 153104 5592 31538643
Blood iron decreased 13.59 12.46 3 153106 4687 31539548
Superior sagittal sinus thrombosis 13.55 12.46 11 153098 265 31543970
Cerebrosclerosis 13.55 12.46 5 153104 21 31544214
Coxsackie viral infection 13.55 12.46 5 153104 21 31544214
Peripheral T-cell lymphoma unspecified stage III 13.52 12.46 6 153103 44 31544191
Dizziness postural 13.48 12.46 5 153104 5563 31538672
Femur fracture 13.47 12.46 10 153099 7523 31536712
Herpes zoster reactivation 13.44 12.46 11 153098 268 31543967
Granulocytopenia neonatal 13.36 12.46 5 153104 22 31544213
Gastric ulcer 13.33 12.46 32 153077 14602 31529633
Increased appetite 13.31 12.46 7 153102 6337 31537898
Enterobacter bacteraemia 13.27 12.46 12 153097 336 31543899
Choking 13.26 12.46 3 153106 4609 31539626
Arteriosclerosis coronary artery 13.26 12.46 21 153088 11187 31533048
Mantle cell lymphoma stage IV 13.22 12.46 8 153101 118 31544117
Tooth hypoplasia 13.22 12.46 8 153101 118 31544117
Cushingoid 13.21 12.46 34 153075 2473 31541762
Respiratory tract congestion 13.21 12.46 5 153104 5492 31538743
Malocclusion 13.19 12.46 7 153102 79 31544156
Fusobacterium infection 13.19 12.46 7 153102 79 31544156
Cold sweat 13.18 12.46 15 153094 9194 31535041
Mediastinal mass 13.18 12.46 9 153100 165 31544070
Sepsis syndrome 13.16 12.46 17 153092 719 31543516
Contraindicated product administered 13.15 12.46 50 153059 19722 31524513
Mental impairment 13.13 12.46 16 153093 9516 31534719
Basal cell carcinoma 13.12 12.46 140 152969 18039 31526196
Premature ageing 13.11 12.46 7 153102 80 31544155
Mania 13.08 12.46 15 153094 9162 31535073
Hepatitis B e antigen positive 13.08 12.46 6 153103 48 31544187
Transitional cell carcinoma 13.07 12.46 30 153079 2029 31542206
Gliosis 13.04 12.46 9 153100 168 31544067
Meningitis enterococcal 13.04 12.46 7 153102 81 31544154
Organising pneumonia 13.03 12.46 57 153052 5453 31538782
Pneumonia measles 13.02 12.46 5 153104 24 31544211
Hepatosplenic abscess 13.01 12.46 3 153106 0 31544235
Klippel-Feil syndrome 13.01 12.46 3 153106 0 31544235
Amniotic fluid volume decreased 13.01 12.46 3 153106 0 31544235
Disseminated large cell lymphoma 13.01 12.46 3 153106 0 31544235
Retrograde portal vein flow 13.01 12.46 3 153106 0 31544235
Ganglioneuroma 13.00 12.46 4 153105 8 31544227
Lymphoplasmacytoid lymphoma/immunocytoma recurrent 13.00 12.46 4 153105 8 31544227
Transaminases increased 12.99 12.46 177 152932 24164 31520071
Polymyositis 12.98 12.46 24 153085 1391 31542844
Haemophilus infection 12.92 12.46 20 153089 1002 31543233
Eosinophilia 12.90 12.46 63 153046 23190 31521045
Laboratory test abnormal 12.89 12.46 47 153062 18767 31525468
Lupus nephritis 12.87 12.46 11 153098 285 31543950
Viral skin infection 12.87 12.46 6 153103 50 31544185
T-cell prolymphocytic leukaemia 12.87 12.46 6 153103 50 31544185
Dry eye 12.85 12.46 12 153097 8060 31536175
Embryonal rhabdomyosarcoma 12.85 12.46 5 153104 25 31544210
Light chain disease 12.82 12.46 8 153101 125 31544110
Hypomagnesaemia 12.81 12.46 48 153061 19010 31525225
Bladder spasm 12.74 12.46 18 153091 830 31543405
Foetal growth restriction 12.72 12.46 44 153065 3771 31540464
Throat tightness 12.69 12.46 11 153098 7658 31536577
Blood glucose abnormal 12.68 12.46 5 153104 5358 31538877
Stomatitis necrotising 12.67 12.46 7 153102 86 31544149
Spinal osteoarthritis 12.67 12.46 9 153100 6926 31537309
Dermatitis acneiform 12.65 12.46 6 153103 5761 31538474
Red blood cell schistocytes present 12.63 12.46 10 153099 232 31544003
Fluid imbalance 12.63 12.46 10 153099 232 31544003
Speech disorder 12.61 12.46 67 153042 24134 31520101
Viral myocarditis 12.60 12.46 8 153101 129 31544106
Asphyxia 12.59 12.46 6 153103 5745 31538490
Ischaemic stroke 12.57 12.46 41 153068 16930 31527305
Atypical pneumonia 12.53 12.46 37 153072 2916 31541319
Intestinal obstruction 12.53 12.46 54 153055 20556 31523679
Benign prostatic hyperplasia 12.52 12.46 28 153081 13097 31531138
Retinitis viral 12.47 12.46 7 153102 89 31544146

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 8572.30 10.93 6964 289298 197354 70434828
Neutropenia 3491.44 10.93 4805 291457 252351 70379831
Cytokine release syndrome 2221.96 10.93 1382 294880 25085 70607097
Myelosuppression 2161.30 10.93 1425 294837 28720 70603462
Product use in unapproved indication 2092.16 10.93 3376 292886 204102 70428080
Bone marrow failure 1920.57 10.93 1611 294651 47399 70584783
Cytomegalovirus infection 1662.04 10.93 1357 294905 38401 70593781
Acute myeloid leukaemia 1616.49 10.93 1205 295057 29735 70602447
Myelodysplastic syndrome 1549.33 10.93 1157 295105 28628 70603554
Mucosal inflammation 1480.11 10.93 1614 294648 66236 70565946
Acute graft versus host disease 1402.88 10.93 720 295542 8842 70623340
Pancytopenia 1341.31 10.93 2324 293938 148783 70483399
Haematotoxicity 1309.25 10.93 777 295485 12897 70619285
Cystitis haemorrhagic 1177.27 10.93 618 295644 7975 70624207
Hypogammaglobulinaemia 1137.06 10.93 668 295594 10870 70621312
Second primary malignancy 1134.41 10.93 697 295565 12354 70619828
Pyrexia 1077.86 10.93 5193 291069 601759 70030423
Venoocclusive liver disease 1064.89 10.93 623 295639 10055 70622127
Thrombocytopenia 1015.98 10.93 2727 293535 236383 70395799
Pneumocystis jirovecii pneumonia 1008.54 10.93 905 295357 29177 70603005
Off label use 1003.73 10.93 5895 290367 737165 69895017
Graft versus host disease 987.13 10.93 673 295589 14350 70617832
Disease progression 985.48 10.93 2082 294180 154590 70477592
Hepatitis B 950.67 10.93 526 295736 7588 70624594
Chronic graft versus host disease 947.71 10.93 494 295768 6276 70625906
Leukopenia 943.73 10.93 1638 294624 104922 70527260
Neutrophil count decreased 922.26 10.93 1419 294843 82137 70550045
Progressive multifocal leukoencephalopathy 914.40 10.93 708 295554 18506 70613676
Diffuse large B-cell lymphoma recurrent 908.13 10.93 390 295872 3086 70629096
Agranulocytosis 898.29 10.93 970 295292 39328 70592854
Cytopenia 889.71 10.93 668 295594 16655 70615527
Rheumatoid arthritis 878.47 10.93 97 296165 291708 70340474
Completed suicide 877.18 10.93 14 296248 227121 70405061
White blood cell count decreased 875.16 10.93 2087 294175 168054 70464128
Diffuse large B-cell lymphoma 850.56 10.93 586 295676 12716 70619466
Fall 831.13 10.93 409 295853 443687 70188495
Pain 807.16 10.93 864 295398 627952 70004230
Acute graft versus host disease in skin 785.33 10.93 444 295818 6693 70625489
Arthralgia 759.09 10.93 596 295666 502794 70129388
Neurotoxicity 752.33 10.93 767 295495 29059 70603123
Sepsis 751.17 10.93 2487 293775 242058 70390124
Posterior reversible encephalopathy syndrome 739.77 10.93 694 295568 23708 70608474
Hepatitis B reactivation 679.55 10.93 366 295896 4989 70627193
Plasma cell myeloma 676.43 10.93 1147 295115 72054 70560128
Neutropenic sepsis 673.06 10.93 664 295598 24166 70608016
Tumour lysis syndrome 663.90 10.93 616 295646 20744 70611438
Septic shock 658.63 10.93 1451 294811 110807 70521375
Febrile bone marrow aplasia 648.45 10.93 477 295785 11514 70620668
Haemophagocytic lymphohistiocytosis 635.62 10.93 579 295683 19033 70613149
Malignant neoplasm progression 626.31 10.93 1494 294768 120245 70511937
Joint swelling 610.22 10.93 153 296109 253058 70379124
Product dose omission issue 606.81 10.93 92 296170 217376 70414806
Epstein-Barr virus infection 581.98 10.93 465 295797 12733 70619449
Cardiotoxicity 577.61 10.93 431 295831 10639 70621543
Venoocclusive disease 575.10 10.93 302 295960 3898 70628284
Multiple organ dysfunction syndrome 569.28 10.93 1342 294920 107173 70525009
Post transplant lymphoproliferative disorder 544.50 10.93 408 295854 10137 70622045
Interstitial lung disease 536.53 10.93 1283 294979 103402 70528780
Neoplasm progression 528.38 10.93 789 295473 44439 70587743
Acute lymphocytic leukaemia recurrent 517.82 10.93 297 295965 4607 70627575
Pruritus 516.65 10.93 412 295850 345148 70287034
Platelet count decreased 514.48 10.93 1776 294486 176446 70455736
Cytomegalovirus infection reactivation 513.68 10.93 332 295930 6449 70625733
BK virus infection 513.21 10.93 353 295909 7636 70624546
Drug abuse 498.08 10.93 29 296233 147227 70484955
Adenovirus infection 493.74 10.93 341 295921 7427 70624755
Synovitis 490.36 10.93 10 296252 129218 70502964
Dizziness 483.59 10.93 745 295517 463396 70168786
Immune effector cell-associated neurotoxicity syndrome 471.80 10.93 260 296002 3718 70628464
Graft versus host disease in skin 469.73 10.93 293 295969 5337 70626845
Disease recurrence 468.17 10.93 676 295586 36927 70595255
Abdominal discomfort 466.98 10.93 157 296105 214501 70417681
Therapy partial responder 463.53 10.93 398 295864 12076 70620106
Peripheral swelling 446.21 10.93 215 296047 236348 70395834
Bronchopulmonary aspergillosis 439.18 10.93 489 295773 20513 70611669
Aspergillus infection 431.57 10.93 449 295813 17419 70614763
Respiratory failure 425.35 10.93 1609 294653 167126 70465056
Drug hypersensitivity 423.07 10.93 289 295973 262170 70370012
Nasopharyngitis 422.06 10.93 200 296062 222006 70410176
Arthropathy 419.57 10.93 63 296199 149994 70482188
Fatigue 418.18 10.93 1899 294363 822420 69809762
Overdose 417.71 10.93 98 296164 169647 70462535
Weight increased 412.18 10.93 251 296011 242080 70390102
Premature menopause 407.94 10.93 133 296129 422 70631760
Anxiety 402.34 10.93 209 296053 220121 70412061
Headache 393.69 10.93 1185 295077 579220 70052962
Intentional overdose 393.68 10.93 3 296259 98432 70533750
Swelling 392.80 10.93 148 296114 188391 70443791
Thrombotic microangiopathy 384.31 10.93 422 295840 17426 70614756
Neuropathy peripheral 383.96 10.93 1285 294977 125611 70506571
Rash 381.24 10.93 995 295267 509567 70122615
Pain in extremity 375.69 10.93 492 295770 327590 70304592
Drug interaction 373.82 10.93 637 295625 380804 70251378
Cytomegalovirus chorioretinitis 373.51 10.93 248 296014 5050 70627132
Cytomegalovirus viraemia 370.86 10.93 341 295921 11344 70620838
Lymphopenia 364.41 10.93 508 295754 26851 70605331
Malaise 362.55 10.93 794 295468 432138 70200044
Injection site pain 358.95 10.93 37 296225 117582 70514600
Graft versus host disease in gastrointestinal tract 343.08 10.93 246 296016 5698 70626484
Blood pressure increased 339.45 10.93 182 296080 188335 70443847
Ejection fraction decreased 337.10 10.93 521 295741 30241 70601941
Musculoskeletal stiffness 333.82 10.93 101 296161 147659 70484523
Cardiomyopathy 329.55 10.93 475 295787 25898 70606284
Stem cell transplant 325.67 10.93 197 296065 3388 70628794
Therapeutic product effect decreased 324.47 10.93 97 296165 142921 70489261
Contraindicated product administered 318.95 10.93 84 296178 134528 70497654
Pemphigus 316.69 10.93 6 296256 83030 70549152
Aplasia 314.41 10.93 253 296009 6998 70625184
Acute lymphocytic leukaemia 314.35 10.93 227 296035 5318 70626864
Psoriasis 310.87 10.93 27 296235 98406 70533776
Wound 309.33 10.93 28 296234 98704 70533478
Glossodynia 305.23 10.93 13 296249 86474 70545708
Feeling abnormal 295.90 10.93 112 296150 142207 70489975
Insomnia 293.46 10.93 286 295976 217520 70414662
Human herpesvirus 6 infection 291.75 10.93 206 296056 4653 70627529
Contusion 286.53 10.93 89 296173 127947 70504235
Bacteraemia 272.87 10.93 461 295801 28848 70603334
Hypersensitivity 263.54 10.93 344 295918 229468 70402714
Lymphadenopathy 257.37 10.93 605 295657 48186 70583996
Somnolence 256.31 10.93 314 295948 215292 70416890
Acute graft versus host disease in intestine 253.12 10.93 172 296090 3644 70628538
Inappropriate schedule of product administration 253.11 10.93 68 296194 107487 70524695
Depression 248.08 10.93 279 295983 198695 70433487
Muscle spasms 246.21 10.93 171 296091 153875 70478307
Urticaria 245.08 10.93 193 296069 162856 70469326
Diffuse large B-cell lymphoma refractory 244.69 10.93 116 296146 1183 70630999
Acute promyelocytic leukaemia 240.43 10.93 120 296142 1382 70630800
Viral haemorrhagic cystitis 240.33 10.93 128 296134 1703 70630479
Epstein-Barr virus associated lymphoproliferative disorder 236.81 10.93 156 296106 3133 70629049
Myocardial infarction 236.28 10.93 221 296041 171424 70460758
Intentional product misuse 235.34 10.93 28 296234 79567 70552615
Suicide attempt 235.01 10.93 28 296234 79482 70552700
Psoriatic arthropathy 234.49 10.93 8 296254 64763 70567419
Ovarian failure 234.47 10.93 89 296173 489 70631693
Dyspnoea 229.77 10.93 2085 294177 767975 69864207
Cytogenetic abnormality 228.73 10.93 104 296158 956 70631226
Metastases to bone 225.84 10.93 365 295897 22011 70610171
Discomfort 222.46 10.93 81 296181 105355 70526827
Polyneuropathy 219.79 10.93 352 295910 21063 70611119
Drug resistance 219.61 10.93 490 295772 37700 70594482
Lymphocyte count decreased 218.98 10.93 530 295732 43009 70589173
JC virus infection 218.91 10.93 153 296109 3398 70628784
Gait disturbance 218.49 10.93 271 295991 184835 70447347
B-cell lymphoma recurrent 217.23 10.93 95 296167 789 70631393
Mobility decreased 214.17 10.93 81 296181 102918 70529264
Asthma 213.89 10.93 119 296143 120674 70511508
Anaemia 213.69 10.93 2599 293663 400824 70231358
Hepatic enzyme increased 210.40 10.93 207 296055 156783 70475399
Secondary immunodeficiency 210.37 10.93 138 296124 2751 70629431
Loss of personal independence in daily activities 208.83 10.93 49 296213 84861 70547321
Herpes simplex 208.60 10.93 246 296016 10986 70621196
Injection site erythema 205.19 10.93 30 296232 72894 70559288
Acquired gene mutation 202.82 10.93 120 296142 1978 70630204
Systemic lupus erythematosus 199.12 10.93 88 296174 101814 70530368
Pleural effusion 197.86 10.93 1085 295177 131779 70500403
Staphylococcal bacteraemia 193.15 10.93 235 296027 10847 70621335
Injury 192.77 10.93 23 296239 65222 70566960
Stress 191.14 10.93 28 296234 67938 70564244
Osteoarthritis 190.02 10.93 39 296223 74108 70558074
Systemic mycosis 189.84 10.93 123 296139 2399 70629783
Neutropenic colitis 189.64 10.93 163 296099 4951 70627231
Left ventricular dysfunction 188.19 10.93 298 295964 17659 70614523
Abdominal pain upper 186.89 10.93 326 295936 193276 70438906
B-cell type acute leukaemia 186.41 10.93 72 296190 418 70631764
Neoplasm recurrence 184.80 10.93 144 296118 3797 70628385
Chronic lymphocytic leukaemia recurrent 184.01 10.93 76 296186 539 70631643
Bacterial infection 182.58 10.93 366 295896 26126 70606056
Hospitalisation 181.84 10.93 59 296203 82509 70549673
Irritable bowel syndrome 181.58 10.93 7 296255 50843 70581339
Hypoglycaemia 180.46 10.93 84 296178 94280 70537902
Mucormycosis 180.39 10.93 194 296068 7820 70624362
Arthritis 177.14 10.93 94 296168 97886 70534296
Pseudomonal sepsis 176.51 10.93 162 296100 5375 70626807
Toxicity to various agents 175.12 10.93 911 295351 381261 70250921
Leukaemia recurrent 174.43 10.93 121 296141 2654 70629528
Rhabdomyolysis 174.41 10.93 91 296171 95669 70536513
Metastases to lymph nodes 174.34 10.93 204 296058 9034 70623148
Heart rate decreased 173.35 10.93 26 296236 61989 70570193
Osteonecrosis 173.14 10.93 379 295883 28781 70603401
Fibromyalgia 172.99 10.93 6 296256 47868 70584314
Duodenal ulcer perforation 172.95 10.93 10 296252 51102 70581080
Enterococcal infection 171.11 10.93 255 296007 14327 70617855
Wheezing 170.76 10.93 90 296172 94080 70538102
Bacterial sepsis 170.17 10.93 184 296078 7463 70624719
Chronic lymphocytic leukaemia 170.13 10.93 162 296100 5636 70626546
Klebsiella infection 169.24 10.93 251 296011 14041 70618141
Chronic graft versus host disease in skin 168.57 10.93 94 296168 1377 70630805
Hepatic failure 168.36 10.93 577 295685 57048 70575134
Drug intolerance 167.85 10.93 440 295822 225247 70406935
Blood glucose increased 167.61 10.93 112 296150 102870 70529312
Confusional state 167.28 10.93 617 295645 283781 70348401
Acute graft versus host disease in liver 166.73 10.93 100 296162 1692 70630490
Candida infection 166.29 10.93 413 295849 34060 70598122
Pneumonia cytomegaloviral 164.33 10.93 143 296119 4418 70627764
Plasma cell myeloma recurrent 162.13 10.93 139 296123 4207 70627975
Blood cholesterol increased 161.42 10.93 36 296226 64568 70567614
Infusion related reaction 161.12 10.93 367 295895 197167 70435015
Bronchitis 160.08 10.93 152 296110 117091 70515091
Pseudomonas infection 158.86 10.93 285 295977 18709 70613473
B-cell lymphoma 157.63 10.93 161 296101 6108 70626074
Engraftment syndrome 156.49 10.93 85 296177 1179 70631003
Leukoencephalopathy 156.21 10.93 172 296090 7122 70625060
Incorrect dose administered 155.41 10.93 43 296219 66676 70565506
Central nervous system lymphoma 154.79 10.93 104 296158 2161 70630021
Congestive cardiomyopathy 154.70 10.93 209 296053 10717 70621465
International normalised ratio increased 154.14 10.93 72 296190 80654 70551528
Helicobacter infection 154.05 10.93 24 296238 55632 70576550
Weight decreased 153.75 10.93 720 295542 309768 70322414
Cerebrovascular accident 152.14 10.93 227 296035 143243 70488939
Suicidal ideation 151.03 10.93 51 296211 69545 70562637
Pneumonia 150.02 10.93 3399 292863 592833 70039349
Metastases to liver 149.86 10.93 333 295929 25545 70606637
Pneumonia fungal 148.00 10.93 195 296067 9758 70622424
Cystitis viral 147.62 10.93 67 296195 613 70631569
Injection site swelling 147.39 10.93 8 296254 43149 70589033
Parainfluenzae virus infection 147.28 10.93 141 296121 4939 70627243
Sedation 147.03 10.93 13 296249 46718 70585464
Serotonin syndrome 146.39 10.93 7 296255 42107 70590075
Rhinovirus infection 144.59 10.93 159 296103 6574 70625608
Injection site bruising 143.99 10.93 3 296259 38029 70594153
Bradycardia 143.29 10.93 186 296076 124429 70507753
Transplant failure 140.43 10.93 125 296137 3982 70628200
Plasmacytoma 139.84 10.93 124 296138 3930 70628252
Blister 138.79 10.93 129 296133 100397 70531785
Metastases to lung 138.71 10.93 248 296014 16236 70615946
Injection site pruritus 137.98 10.93 6 296256 39204 70592978
Cardiac dysfunction 137.84 10.93 116 296146 3421 70628761
Staphylococcal infection 137.44 10.93 513 295749 52891 70579291
Clostridium difficile colitis 136.30 10.93 344 295918 28652 70603530
Refractory anaemia with an excess of blasts 135.69 10.93 69 296193 829 70631353
Loss of consciousness 134.66 10.93 280 295982 155436 70476746
Coronary artery disease 134.36 10.93 47 296215 62689 70569493
Cytomegalovirus test positive 134.05 10.93 139 296123 5369 70626813
Peripheral sensory neuropathy 133.90 10.93 206 296056 11904 70620278
Aggression 133.84 10.93 21 296241 48425 70583757
Cardiac failure 133.81 10.93 1042 295220 142499 70489683
Balance disorder 132.48 10.93 109 296153 90019 70542163
Sweat gland tumour 131.63 10.93 57 296205 461 70631721
Blood lactate dehydrogenase increased 131.30 10.93 383 295879 34744 70597438
Sinusitis 131.06 10.93 323 295939 168872 70463310
Mantle cell lymphoma recurrent 130.17 10.93 57 296205 475 70631707
Fusarium infection 129.21 10.93 84 296178 1648 70630534
Disseminated intravascular coagulation 129.13 10.93 370 295892 33228 70598954
Condition aggravated 128.74 10.93 1154 295108 426481 70205701
Varicella zoster virus infection 128.34 10.93 119 296143 4001 70628181
Chronic obstructive pulmonary disease 128.28 10.93 83 296179 77558 70554624
Migraine 128.10 10.93 71 296191 72167 70560015
Staphylococcal sepsis 127.36 10.93 213 296049 13214 70618968
Myelopathy 127.07 10.93 120 296142 4131 70628051
Blood pressure fluctuation 126.74 10.93 44 296218 58968 70573214
Hepatotoxicity 126.36 10.93 438 295824 43548 70588634
Blood follicle stimulating hormone increased 124.51 10.93 48 296214 277 70631905
C-reactive protein abnormal 123.38 10.93 10 296252 38569 70593613
Escherichia bacteraemia 123.28 10.93 137 296125 5732 70626450
Hyperhidrosis 122.96 10.93 226 296036 131360 70500822
Blood pressure systolic increased 122.45 10.93 43 296219 57216 70574966
Injection site reaction 122.11 10.93 29 296233 49823 70582359
Back pain 122.04 10.93 650 295612 270502 70361680
Lymphoma 121.71 10.93 226 296036 15236 70616946
Hyperkalaemia 121.62 10.93 160 296102 106431 70525751
Infection reactivation 120.68 10.93 91 296171 2282 70629900
Enterococcal bacteraemia 120.07 10.93 96 296166 2630 70629552
Nephropathy toxic 119.55 10.93 249 296013 18265 70613917
Recurrent cancer 118.40 10.93 91 296171 2350 70629832
Multiple sclerosis relapse 118.03 10.93 19 296243 42998 70589184
Hallucination 117.42 10.93 88 296174 76172 70556010
Angioedema 117.34 10.93 66 296196 66544 70565638
Hypoxia 116.05 10.93 727 295535 92617 70539565
Chest pain 116.04 10.93 597 295665 250663 70381519
Capillary leak syndrome 115.66 10.93 104 296158 3358 70628824
Breast cancer metastatic 115.58 10.93 175 296087 9971 70622211
Fungal infection 115.47 10.93 382 295880 37085 70595097
Aplastic anaemia 115.25 10.93 231 296031 16485 70615697
Pneumonitis 115.25 10.93 493 295769 54104 70578078
Gene mutation 114.62 10.93 87 296175 2204 70629978
Musculoskeletal pain 114.31 10.93 125 296137 90202 70541980
Impaired healing 114.29 10.93 86 296176 74288 70557894
Systemic candida 113.58 10.93 132 296130 5802 70626380
Organising pneumonia 112.59 10.93 172 296090 9878 70622304
Plasma cell leukaemia 111.58 10.93 79 296183 1792 70630390
End stage renal disease 111.51 10.93 181 296081 10952 70621230
Metastases to central nervous system 111.22 10.93 214 296048 14820 70617362
Acute respiratory distress syndrome 110.95 10.93 402 295860 40852 70591330
Refractory cytopenia with multilineage dysplasia 110.76 10.93 42 296220 230 70631952
Neck pain 110.48 10.93 71 296191 66586 70565596
Gastrooesophageal reflux disease 110.29 10.93 130 296132 90709 70541473
Sleep disorder 109.69 10.93 79 296183 69793 70562389
Infection 109.15 10.93 1353 294909 209432 70422750
Autoimmune haemolytic anaemia 107.89 10.93 147 296115 7599 70624583
Breast cancer recurrent 107.61 10.93 91 296171 2702 70629480
Product prescribing error 107.34 10.93 17 296245 38935 70593247
Palpitations 106.36 10.93 187 296075 110566 70521616
Escherichia sepsis 106.35 10.93 144 296118 7399 70624783
Drug ineffective for unapproved indication 105.74 10.93 378 295884 38160 70594022
Urinary tract infection 105.56 10.93 608 295654 248161 70384021
Lung infiltration 105.27 10.93 260 296002 21364 70610818
Metastasis 103.88 10.93 128 296134 5986 70626196
Electrocardiogram QT prolonged 103.03 10.93 118 296144 83399 70548783
Graft versus host disease in liver 102.75 10.93 71 296191 1547 70630635
Heart rate increased 102.13 10.93 179 296083 105969 70526213
Myeloid leukaemia 102.05 10.93 51 296211 589 70631593
Primary amyloidosis 101.82 10.93 37 296225 176 70632006
Blood stem cell transplant failure 101.46 10.93 48 296214 487 70631695
Computerised tomogram thorax abnormal 101.29 10.93 78 296184 2020 70630162
Lymphoproliferative disorder 101.09 10.93 118 296144 5211 70626971
Emotional distress 100.75 10.93 17 296245 37171 70595011
Drug withdrawal syndrome 100.53 10.93 10 296252 32705 70599477
Viraemia 99.74 10.93 83 296179 2409 70629773
Type 2 diabetes mellitus 99.73 10.93 30 296232 44050 70588132
Minimal residual disease 99.53 10.93 44 296218 376 70631806
Dyspepsia 98.29 10.93 137 296125 88940 70543242
Nasal congestion 98.28 10.93 78 296184 65594 70566588
Colitis 98.21 10.93 526 295736 63288 70568894
Lactic acidosis 97.60 10.93 77 296185 64947 70567235
Encephalitis 97.60 10.93 191 296071 13394 70618788
Product quality issue 97.52 10.93 8 296254 30553 70601629
Respiratory syncytial virus infection 97.26 10.93 139 296123 7516 70624666
Bone pain 96.75 10.93 445 295817 50377 70581805
Escherichia infection 96.65 10.93 212 296050 16119 70616063
Accidental overdose 95.27 10.93 16 296246 35105 70597077
Acute myelomonocytic leukaemia 95.10 10.93 39 296223 271 70631911
Chronic myeloid leukaemia 95.09 10.93 102 296160 4099 70628083
Pulmonary alveolar haemorrhage 95.05 10.93 162 296100 10207 70621975
Pneumatosis intestinalis 94.83 10.93 120 296142 5767 70626415
Adverse event 94.59 10.93 44 296218 49417 70582765
Oedema peripheral 94.34 10.93 562 295700 227529 70404653
Unevaluable event 94.01 10.93 50 296212 52013 70580169
Memory impairment 93.95 10.93 151 296111 92490 70539692
Agitation 93.94 10.93 153 296109 93222 70538960
Swollen tongue 93.85 10.93 20 296242 37026 70595156
Primary hypogonadism 93.09 10.93 33 296229 144 70632038
Nocardiosis 93.04 10.93 111 296151 5018 70627164
Injection site haemorrhage 92.93 10.93 3 296259 25524 70606658
Rash pruritic 92.79 10.93 76 296186 62915 70569267
Folliculitis 92.70 10.93 31 296231 42539 70589643
Strongyloidiasis 92.49 10.93 95 296167 3628 70628554
Ovarian atrophy 92.47 10.93 28 296234 64 70632118
Myalgia 92.34 10.93 374 295888 167518 70464664
Nephrolithiasis 92.21 10.93 41 296221 47282 70584900
Therapy non-responder 91.85 10.93 593 295669 76322 70555860
Human polyomavirus infection 91.22 10.93 56 296206 990 70631192
Joint stiffness 91.16 10.93 18 296244 35158 70597024
Microsporidia infection 91.12 10.93 53 296209 845 70631337
Adverse drug reaction 90.92 10.93 55 296207 53289 70578893
Pulmonary haemorrhage 90.76 10.93 186 296076 13487 70618695
Complications of bone marrow transplant 90.70 10.93 47 296215 589 70631593
Chronic graft versus host disease in liver 90.22 10.93 46 296216 556 70631626
Blood creatine phosphokinase increased 90.14 10.93 74 296188 61189 70570993
Death 89.62 10.93 1545 294717 508516 70123666
Peripheral T-cell lymphoma unspecified 89.36 10.93 51 296211 783 70631399
Mycobacterium chelonae infection 88.98 10.93 76 296186 2288 70629894
Chemotherapy 88.97 10.93 65 296197 1551 70630631
Medication error 88.48 10.93 65 296197 56847 70575335
Chest discomfort 88.26 10.93 248 296014 124133 70508049
Leukaemia cutis 87.59 10.93 32 296230 155 70632027
Biopsy lung abnormal 87.14 10.93 31 296231 137 70632045
Intestinal perforation 86.82 10.93 201 296061 15843 70616339
Encephalopathy 86.70 10.93 496 295766 61165 70571017
Neutrophil count abnormal 86.50 10.93 85 296177 3076 70629106
Oxygen saturation decreased 86.48 10.93 227 296035 116202 70515980
Nausea 85.99 10.93 2810 293452 849278 69782904
Acute myeloid leukaemia recurrent 85.21 10.93 83 296179 2971 70629211
Anti-Muellerian hormone level decreased 84.94 10.93 27 296235 77 70632105
Respiratory arrest 84.63 10.93 61 296201 53872 70578310
5q minus syndrome 84.56 10.93 36 296226 278 70631904
Diarrhoea 84.15 10.93 2562 293700 780779 69851403
Pericarditis 84.09 10.93 140 296122 84565 70547617
Dry mouth 83.22 10.93 103 296159 70354 70561828
Tremor 82.88 10.93 351 295911 155273 70476909
Colony stimulating factor therapy 82.42 10.93 42 296220 507 70631675
Pneumomediastinum 81.93 10.93 85 296177 3285 70628897
Plasmablastic lymphoma 81.87 10.93 43 296219 555 70631627
Skin toxicity 81.78 10.93 124 296138 7074 70625108
Anti-neutrophil cytoplasmic antibody positive vasculitis 81.67 10.93 84 296178 3213 70628969
Palmar-plantar erythrodysaesthesia syndrome 81.55 10.93 295 295967 29952 70602230
Burning sensation 81.40 10.93 61 296201 52809 70579373
Nodular regenerative hyperplasia 80.38 10.93 56 296206 1237 70630945
White blood cell count abnormal 80.13 10.93 105 296157 5225 70626957
Alopecia 80.00 10.93 493 295769 197997 70434185
Illness 78.84 10.93 18 296244 31773 70600409
Colitis ulcerative 78.74 10.93 22 296240 33901 70598281
Lupus nephritis 78.57 10.93 77 296185 2777 70629405
Acute monocytic leukaemia 78.56 10.93 40 296222 482 70631700
Device related infection 78.53 10.93 304 295958 31881 70600301
Nervousness 78.43 10.93 17 296245 31103 70601079
Restlessness 78.23 10.93 39 296223 42089 70590093
Labelled drug-drug interaction medication error 77.87 10.93 6 296256 24121 70608061
Road traffic accident 77.74 10.93 24 296238 34658 70597524
Engraft failure 77.64 10.93 43 296219 621 70631561
Hypertension 77.54 10.93 826 295436 295207 70336975
Prescribed overdose 76.87 10.93 11 296251 27170 70605012
Osteosarcoma 76.74 10.93 37 296225 393 70631789
Drug dependence 76.48 10.93 30 296232 37291 70594891
Enterobacter infection 75.52 10.93 89 296173 3971 70628211
Klebsiella sepsis 75.38 10.93 75 296187 2756 70629426
Encephalitis viral 75.03 10.93 70 296192 2372 70629810
Toxoplasmosis 74.83 10.93 72 296190 2538 70629644
Flatulence 74.52 10.93 33 296229 38148 70594034
Treatment noncompliance 73.96 10.93 52 296210 46522 70585660
Myelitis 73.32 10.93 67 296195 2210 70629972
Pneumocystis jirovecii infection 73.31 10.93 71 296191 2523 70629659
Haematochezia 73.27 10.93 120 296142 72961 70559221
Withdrawal syndrome 73.01 10.93 9 296253 24895 70607287
Bone marrow transplant rejection 72.75 10.93 31 296231 240 70631942
Drug reaction with eosinophilia and systemic symptoms 72.60 10.93 81 296181 57932 70574250
Multiple sclerosis 72.06 10.93 10 296252 25275 70606907
Bone marrow disorder 72.05 10.93 75 296187 2910 70629272
Human herpesvirus 8 infection 71.62 10.93 49 296213 1050 70631132
Limb injury 71.50 10.93 11 296251 25741 70606441
Neuroblastoma 71.50 10.93 33 296229 315 70631867
Malignant transformation 71.05 10.93 50 296212 1123 70631059
Cytomegalovirus colitis 71.03 10.93 88 296174 4138 70628044
Chronic myelomonocytic leukaemia 70.89 10.93 45 296217 846 70631336
Epstein-Barr viraemia 70.71 10.93 61 296201 1862 70630320
Cerebral toxoplasmosis 70.51 10.93 63 296199 2017 70630165
Pseudocirrhosis 70.26 10.93 40 296222 611 70631571
Abdominal pain 70.22 10.93 1006 295256 341121 70291061
Alpha haemolytic streptococcal infection 69.65 10.93 62 296200 1975 70630207
Gastrointestinal toxicity 69.48 10.93 108 296154 6297 70625885
Pulmonary toxicity 69.45 10.93 145 296117 10653 70621529
Sopor 69.44 10.93 22 296240 31245 70600937
Smooth muscle cell neoplasm 69.34 10.93 45 296217 880 70631302
Cardio-respiratory arrest 69.03 10.93 204 296058 100473 70531709
Surgery 68.59 10.93 20 296242 29969 70602213
Fluid retention 68.42 10.93 99 296163 63286 70568896
Metabolic acidosis 68.27 10.93 129 296133 74217 70557965
Depressed mood 68.18 10.93 50 296212 43770 70588412
Epstein-Barr virus infection reactivation 68.08 10.93 54 296208 1462 70630720
Peripheral motor neuropathy 67.32 10.93 74 296188 3058 70629124
Aortitis 67.12 10.93 52 296210 1359 70630823
Foot deformity 67.05 10.93 5 296257 20650 70611532
Traumatic lung injury 66.86 10.93 64 296198 2241 70629941
Gastric disorder 66.30 10.93 28 296234 33294 70598888
Blood luteinising hormone increased 66.28 10.93 27 296235 184 70631998
Frequent bowel movements 66.23 10.93 6 296256 21147 70611035
Amnesia 66.17 10.93 72 296190 52083 70580099
Skin laceration 65.49 10.93 14 296248 25864 70606318
Fungaemia 65.42 10.93 83 296179 3999 70628183
Splenomegaly 65.08 10.93 200 296062 18670 70613512
Paraparesis 64.94 10.93 78 296184 3551 70628631
B-cell aplasia 64.48 10.93 26 296236 172 70632010
Blood fibrinogen decreased 64.40 10.93 56 296206 1728 70630454
Brain abscess 64.12 10.93 87 296175 4479 70627703
Joint range of motion decreased 64.01 10.93 15 296247 26011 70606171
Maternal exposure during pregnancy 64.00 10.93 256 296006 115089 70517093
Encephalitis cytomegalovirus 63.93 10.93 45 296217 1011 70631171
Therapy responder 63.86 10.93 33 296229 411 70631771
Meningitis cryptococcal 63.64 10.93 74 296188 3254 70628928
Stomatitis 63.10 10.93 817 295445 127694 70504488
Leukaemia 63.06 10.93 94 296168 5281 70626901
Coma 63.04 10.93 186 296076 91658 70540524
Dry eye 62.85 10.93 28 296234 32254 70599928
Respiratory tract infection fungal 62.63 10.93 46 296216 1107 70631075
Bursitis 62.47 10.93 17 296245 26656 70605526
Hypoaesthesia 62.38 10.93 381 295881 153358 70478824
Adult T-cell lymphoma/leukaemia 62.27 10.93 35 296227 521 70631661
Femur fracture 61.93 10.93 37 296225 36095 70596087
Adenovirus reactivation 61.86 10.93 30 296232 323 70631859
Hyperpyrexia 61.65 10.93 93 296169 5281 70626901
T-cell lymphoma 61.65 10.93 48 296214 1264 70630918
Obliterative bronchiolitis 60.54 10.93 67 296195 2790 70629392
Amyloidosis 60.32 10.93 66 296196 2713 70629469
Anaplastic lymphoma kinase gene mutation 60.31 10.93 22 296240 106 70632076
Ileus paralytic 60.31 10.93 121 296141 8640 70623542
Nightmare 60.30 10.93 10 296252 22146 70610036
Acne 60.29 10.93 15 296247 24974 70607208
Foot fracture 60.20 10.93 6 296256 19594 70612588
Metastases to skin 60.14 10.93 51 296211 1520 70630662
Gastrosplenic fistula 60.08 10.93 20 296242 69 70632113
Gait inability 59.99 10.93 65 296197 47110 70585072
Dyskinesia 59.94 10.93 50 296212 41024 70591158
Polyomavirus-associated nephropathy 59.89 10.93 90 296172 5093 70627089
Head injury 59.88 10.93 34 296228 34107 70598075
Pericardial effusion 59.35 10.93 337 295925 41439 70590743
Hip fracture 59.11 10.93 22 296240 28241 70603941
Remission not achieved 59.03 10.93 30 296232 360 70631822
Wrong technique in product usage process 58.95 10.93 124 296138 68574 70563608
Guillain-Barre syndrome 58.92 10.93 114 296148 7926 70624256
Adenoviral haemorrhagic cystitis 58.84 10.93 33 296229 489 70631693
Therapy cessation 58.40 10.93 34 296228 33642 70598540
Candida sepsis 58.34 10.93 60 296202 2295 70629887
Epstein-Barr virus associated lymphoma 58.32 10.93 43 296219 1041 70631141
Vertigo 58.13 10.93 108 296154 62535 70569647
Diffuse alveolar damage 58.09 10.93 71 296191 3292 70628890
Central nervous system fungal infection 58.03 10.93 31 296231 415 70631767
Panic attack 57.99 10.93 11 296251 22108 70610074
Focal nodular hyperplasia 57.83 10.93 36 296226 653 70631529
Poisoning 57.74 10.93 12 296250 22610 70609572
Erythema 57.55 10.93 544 295718 199019 70433163
Fear 57.53 10.93 9 296253 20802 70611380
Device dislocation 57.32 10.93 12 296250 22495 70609687
Alveolar soft part sarcoma 57.22 10.93 20 296242 83 70632099
Graft versus host disease in lung 56.87 10.93 38 296224 782 70631400
Human bocavirus infection 56.85 10.93 34 296228 572 70631610
Hip arthroplasty 56.70 10.93 23 296239 28017 70604165
Flushing 56.70 10.93 166 296096 82006 70550176
Idiopathic pneumonia syndrome 56.41 10.93 33 296229 532 70631650
Refractory cytopenia with unilineage dysplasia 56.00 10.93 39 296223 861 70631321
Respiratory depression 55.99 10.93 17 296245 24814 70607368
Adenoviral hepatitis 55.84 10.93 38 296224 807 70631375
Lymphoma transformation 55.72 10.93 25 296237 222 70631960
Injection site mass 55.34 10.93 6 296256 18337 70613845
Ocular hyperaemia 55.32 10.93 17 296245 24622 70607560
Vision blurred 55.13 10.93 207 296055 94777 70537405
Clostridium difficile infection 55.06 10.93 313 295949 38503 70593679
Invasive ductal breast carcinoma 54.89 10.93 92 296170 5717 70626465
Venous thrombosis 54.62 10.93 99 296163 6550 70625632
Alopecia areata 54.37 10.93 49 296213 1587 70630595
Chloroma 54.21 10.93 36 296226 733 70631449
Faeces discoloured 54.19 10.93 22 296240 26787 70605395
Blood pressure diastolic decreased 54.03 10.93 20 296242 25760 70606422
Hepatosplenomegaly 53.85 10.93 90 296172 5580 70626602
Blood glucose decreased 53.65 10.93 17 296245 24142 70608040
Sciatica 53.50 10.93 18 296244 24609 70607573
Abnormal behaviour 53.49 10.93 40 296222 34669 70597513
B precursor type acute leukaemia 53.23 10.93 30 296232 449 70631733
Autoimmune neutropenia 53.06 10.93 30 296232 452 70631730
Cardiomyopathy acute 52.98 10.93 25 296237 252 70631930
Limb discomfort 52.94 10.93 29 296233 29676 70602506
Lip swelling 52.79 10.93 39 296223 34015 70598167
Crying 52.57 10.93 12 296250 21187 70610995
Anaplastic large-cell lymphoma 52.55 10.93 27 296235 332 70631850
Tendonitis 51.99 10.93 14 296248 22108 70610074
Glioma 51.91 10.93 32 296230 570 70631612
Mantle cell lymphoma 51.90 10.93 49 296213 1686 70630496
B-lymphocyte count abnormal 51.82 10.93 18 296244 73 70632109
Multifocal micronodular pneumocyte hyperplasia 51.82 10.93 18 296244 73 70632109
Exposure during pregnancy 51.67 10.93 190 296072 87527 70544655
High-grade B-cell lymphoma 51.58 10.93 23 296239 201 70631981
Bronchial polyp 51.44 10.93 18 296244 75 70632107
Device issue 51.43 10.93 18 296244 24007 70608175
Dry skin 51.39 10.93 97 296165 55834 70576348
Nervous system disorder 50.91 10.93 218 296044 23928 70608254
Enterococcal sepsis 50.82 10.93 58 296204 2499 70629683
Rheumatoid nodule 50.81 10.93 3 296259 15064 70617118
Red blood cell sedimentation rate increased 50.53 10.93 52 296210 38590 70593592
Myelitis transverse 50.50 10.93 48 296214 1666 70630516
Pneumonia klebsiella 50.33 10.93 77 296185 4427 70627755
Syncope 50.24 10.93 446 295816 165263 70466919
Bone marrow transplant 50.16 10.93 43 296219 1301 70630881
Bone marrow infiltration 50.10 10.93 30 296232 506 70631676
Movement disorder 50.09 10.93 19 296243 24110 70608072
Cholelithiasis 50.05 10.93 75 296187 47265 70584917
Eye swelling 50.03 10.93 18 296244 23596 70608586
Granulomatosis with polyangiitis 50.00 10.93 58 296204 2544 70629638
Asthenia 49.91 10.93 1493 294769 456173 70176009
Metastases to bone marrow 49.69 10.93 33 296229 672 70631510
Polyomavirus viraemia 49.61 10.93 42 296220 1249 70630933
Ascites 49.53 10.93 465 295797 67082 70565100
Human herpesvirus 6 encephalitis 49.44 10.93 29 296233 470 70631712
Swelling face 49.33 10.93 120 296142 63044 70569138
Blood culture positive 49.31 10.93 105 296157 7821 70624361
Procedural pain 49.30 10.93 8 296254 18001 70614181
Therapy interrupted 49.09 10.93 21 296241 24781 70607401
Herpes virus infection 49.04 10.93 94 296168 6490 70625692
Oesophageal candidiasis 48.72 10.93 109 296153 8398 70623784
Feeling hot 48.71 10.93 80 296182 48590 70583592
Haematocrit decreased 48.60 10.93 407 295855 56851 70575331
Aphasia 48.33 10.93 328 295934 42921 70589261
Acute myocardial infarction 48.31 10.93 150 296112 72737 70559445
Kidney infection 48.27 10.93 11 296251 19444 70612738
Orthostatic hypotension 48.19 10.93 89 296173 51654 70580528
Mood altered 48.18 10.93 6 296256 16469 70615713
Steroid diabetes 48.13 10.93 61 296201 2936 70629246
Injection site rash 47.94 10.93 6 296256 16404 70615778
Skin discolouration 47.93 10.93 51 296211 37274 70594908
Throat irritation 47.89 10.93 46 296216 35258 70596924
Diffuse large B-cell lymphoma stage IV 47.82 10.93 31 296231 605 70631577
Diabetic ketoacidosis 47.68 10.93 37 296225 31475 70600707
Cerebral aspergillosis 47.64 10.93 47 296215 1709 70630473
Lower respiratory tract infection fungal 47.63 10.93 35 296227 843 70631339
Cutaneous calcification 47.59 10.93 19 296243 122 70632060
Sleep apnoea syndrome 47.52 10.93 40 296222 32673 70599509
Subclavian vein thrombosis 47.44 10.93 54 296208 2320 70629862
Transient ischaemic attack 47.41 10.93 74 296188 45870 70586312
Neuroblastoma recurrent 47.26 10.93 18 296244 100 70632082
Graft versus host disease in eye 47.22 10.93 24 296238 288 70631894
Hypersomnia 47.21 10.93 14 296248 20750 70611432
Device related thrombosis 47.14 10.93 54 296208 2336 70629846
Irritability 47.14 10.93 54 296208 38171 70594011
Liver function test abnormal 47.10 10.93 117 296145 61029 70571153
Delirium 47.05 10.93 157 296105 74457 70557725
Eczema 47.02 10.93 43 296219 33738 70598444
Abdominal distension 46.97 10.93 251 296011 104418 70527764
COVID-19 pneumonia 46.83 10.93 199 296063 21770 70610412
Alveolitis 46.66 10.93 68 296194 3743 70628439
Cardiac disorder 46.30 10.93 113 296149 59302 70572880
Blood calcium decreased 46.08 10.93 32 296230 28814 70603368
Toxic cardiomyopathy 46.07 10.93 25 296237 346 70631836
Alveolar proteinosis 45.98 10.93 31 296231 648 70631534
Therapeutic response unexpected 45.86 10.93 10 296252 18221 70613961
Enterovirus infection 45.85 10.93 45 296217 1626 70630556
Haematopoietic stem cell mobilisation 45.81 10.93 21 296241 197 70631985
Granulocyte count decreased 45.72 10.93 42 296220 1395 70630787
Pneumonia adenoviral 45.63 10.93 27 296235 445 70631737
Hot flush 45.55 10.93 86 296176 49498 70582684
Abortion spontaneous 45.54 10.93 27 296235 26452 70605730
Pulmonary veno-occlusive disease 45.22 10.93 43 296219 1493 70630689
Exostosis 45.10 10.93 4 296258 14341 70617841
Pulmonary vascular disorder 45.04 10.93 35 296227 919 70631263
Sinus congestion 44.79 10.93 9 296253 17364 70614818
Nephroblastoma 44.65 10.93 18 296244 119 70632063
Granulocytopenia 44.60 10.93 121 296141 10526 70621656
Acute leukaemia 44.49 10.93 44 296218 1605 70630577
Eye pain 44.46 10.93 46 296216 34056 70598126
Influenza like illness 44.33 10.93 133 296129 65198 70566984
Acute hepatitis B 44.18 10.93 26 296236 424 70631758
Cataract 44.02 10.93 105 296157 55540 70576642
Meningoencephalitis herpetic 44.02 10.93 46 296216 1793 70630389
Disease susceptibility 43.99 10.93 23 296239 294 70631888
Influenza 43.93 10.93 286 295976 113414 70518768
Chronic lymphocytic leukaemia transformation 43.80 10.93 21 296241 220 70631962
Respiratory tract congestion 43.76 10.93 10 296252 17643 70614539
Refractory cancer 43.56 10.93 21 296241 223 70631959
Dystonia 43.52 10.93 14 296248 19692 70612490
T-cell type acute leukaemia 43.51 10.93 22 296240 261 70631921
Systemic scleroderma 43.48 10.93 37 296225 1108 70631074
Delusion 43.43 10.93 13 296249 19152 70613030
Bone marrow necrosis 43.31 10.93 21 296241 226 70631956
Hepatomegaly 43.31 10.93 166 296096 17326 70614856
Chronic lymphocytic leukaemia refractory 43.30 10.93 18 296244 130 70632052
Localised infection 42.92 10.93 45 296217 33113 70599069
Grip strength decreased 42.87 10.93 7 296255 15678 70616504
Thymus hypoplasia 42.85 10.93 29 296233 610 70631572
Rectal haemorrhage 42.56 10.93 137 296125 65694 70566488
Hallucination, visual 42.45 10.93 36 296226 29301 70602881
Blood pressure diastolic abnormal 42.19 10.93 7 296255 15497 70616685
Retinal haemorrhage 42.17 10.93 97 296165 7613 70624569
Hernia 42.06 10.93 6 296256 14854 70617328
Hepatitis E 42.04 10.93 54 296208 2634 70629548
Herpes zoster 41.87 10.93 542 295720 84693 70547489
Presyncope 41.87 10.93 57 296205 37381 70594801
Body temperature decreased 41.72 10.93 35 296227 28637 70603545
Muscle rigidity 41.63 10.93 13 296249 18637 70613545
Salivary gland cancer 41.58 10.93 25 296237 425 70631757
Myeloproliferative neoplasm 41.43 10.93 33 296229 899 70631283
Middle insomnia 41.39 10.93 5 296257 14048 70618134
Underdose 41.38 10.93 37 296225 29346 70602836
Blast cells present 41.31 10.93 32 296230 836 70631346
Administration site extravasation 41.18 10.93 36 296226 1119 70631063
Pulmonary arteriopathy 41.12 10.93 16 296246 95 70632087
Peritonitis pneumococcal 41.04 10.93 12 296250 23 70632159
Klebsiella bacteraemia 41.02 10.93 53 296209 2601 70629581
Chronic kidney disease 40.93 10.93 125 296137 60932 70571250
Scedosporium infection 40.76 10.93 39 296223 1365 70630817
Nephrotic syndrome 40.71 10.93 117 296145 10523 70621659
Extravasation 40.71 10.93 60 296202 3337 70628845
Product administration error 40.60 10.93 38 296224 29485 70602697
Lower limb fracture 40.59 10.93 10 296252 16762 70615420
Hallucination, auditory 40.51 10.93 13 296249 18315 70613867
Extrapyramidal disorder 40.39 10.93 18 296244 20732 70611450
Invasive lobular breast carcinoma 40.29 10.93 28 296234 616 70631566
Anger 40.27 10.93 9 296253 16123 70616059
Ventricular hypokinesia 40.24 10.93 99 296163 8113 70624069
Muscle spasticity 40.05 10.93 16 296246 19673 70612509
Constipation 40.02 10.93 778 295484 251660 70380522
Lymphoid tissue hypoplasia 39.85 10.93 27 296235 569 70631613
Opportunistic infection 39.75 10.93 53 296209 2683 70629499
Streptococcal bacteraemia 39.69 10.93 57 296205 3096 70629086
Blood pressure decreased 39.66 10.93 222 296040 91293 70540889
Psychotic disorder 39.60 10.93 60 296202 37641 70594541
Glioblastoma multiforme 39.58 10.93 37 296225 1257 70630925
Restless legs syndrome 39.12 10.93 14 296248 18414 70613768
Glycosylated haemoglobin increased 39.04 10.93 12 296250 17379 70614803
Central nervous system leukaemia 39.04 10.93 23 296239 376 70631806
Iron deficiency anaemia 39.02 10.93 24 296238 23048 70609134
Immunosuppression 38.88 10.93 121 296141 11371 70620811
Cyst 38.79 10.93 4 296258 12715 70619467
Hypertriglyceridaemia 38.71 10.93 123 296139 11688 70620494
Angiocentric lymphoma 38.68 10.93 32 296230 921 70631261
Rash macular 38.64 10.93 30 296232 25514 70606668
Lymphocytosis 38.63 10.93 63 296199 3827 70628355
Metastases to spleen 38.50 10.93 26 296236 545 70631637
Periarticular thenar erythema with onycholysis 38.35 10.93 11 296251 19 70632163
Respirovirus test positive 38.21 10.93 16 296246 118 70632064
Poor venous access 38.09 10.93 8 296254 14963 70617219
Acute lymphocytic leukaemia refractory 38.08 10.93 17 296245 149 70632033
Upper respiratory fungal infection 38.06 10.93 21 296241 301 70631881
Visual impairment 37.94 10.93 189 296073 80061 70552121
Respiratory tract infection 37.93 10.93 305 295957 42093 70590089
Blood potassium increased 37.78 10.93 35 296227 27291 70604891
Rhabdomyosarcoma recurrent 37.48 10.93 15 296247 97 70632085
Neutropenic infection 37.30 10.93 44 296218 1965 70630217
Pneumonia respiratory syncytial viral 37.17 10.93 38 296224 1443 70630739
Metastases to pleura 37.11 10.93 36 296226 1282 70630900
West Nile viral infection 37.01 10.93 31 296231 908 70631274
Respiratory distress 37.01 10.93 370 295892 54280 70577902
Spinal stenosis 36.93 10.93 8 296254 14645 70617537
Madarosis 36.84 10.93 49 296213 2474 70629708
Gastrointestinal necrosis 36.81 10.93 72 296190 5046 70627136
Thyroid disorder 36.74 10.93 5 296257 12827 70619355
Cystitis bacterial 36.60 10.93 24 296238 478 70631704
Hepatosplenic T-cell lymphoma 36.47 10.93 31 296231 927 70631255
Cryptococcosis 36.16 10.93 56 296206 3254 70628928
Clostridium bacteraemia 36.10 10.93 20 296242 289 70631893
Gastrointestinal haemorrhage 36.08 10.93 383 295879 137025 70495157
Febrile infection 35.95 10.93 54 296208 3055 70629127
Herpes simplex encephalitis 35.91 10.93 27 296235 674 70631508
Dehydration 35.83 10.93 697 295565 225445 70406737
Sneezing 35.77 10.93 13 296249 16938 70615244
Campylobacter infection 35.61 10.93 39 296223 1605 70630577
Cardiac arrest 35.60 10.93 462 295800 159372 70472810
Autonomic neuropathy 35.58 10.93 40 296222 1695 70630487
Drug effective for unapproved indication 35.54 10.93 67 296195 4568 70627614
Ankle fracture 35.52 10.93 10 296252 15334 70616848
Pathogen resistance 35.36 10.93 129 296133 13150 70619032
Metaplasia 35.30 10.93 22 296240 400 70631782
Anaphylactic reaction 35.20 10.93 177 296085 74797 70557385
Schizophrenia 35.15 10.93 13 296249 16755 70615427
Prescribed underdose 35.13 10.93 23 296239 21362 70610820
Choking 35.00 10.93 3 296259 11057 70621125
Ear infection 34.97 10.93 40 296222 28296 70603886
B-cell lymphoma refractory 34.89 10.93 15 296247 119 70632063
Rotavirus infection 34.82 10.93 26 296236 642 70631540
Dysphonia 34.71 10.93 101 296161 49999 70582183
Clostridium colitis 34.69 10.93 48 296214 2518 70629664
Precursor T-lymphoblastic lymphoma/leukaemia 34.67 10.93 15 296247 121 70632061
Pregnancy 34.64 10.93 29 296233 23752 70608430
Pseudomonal bacteraemia 34.60 10.93 48 296214 2524 70629658
Cough 34.54 10.93 1065 295197 324312 70307870
Sinus disorder 34.53 10.93 18 296244 18941 70613241
Therapeutic response shortened 34.49 10.93 6 296256 12832 70619350
Primitive neuroectodermal tumour 34.48 10.93 12 296250 49 70632133
Candida pneumonia 34.48 10.93 23 296239 472 70631710
Serum ferritin increased 34.43 10.93 99 296163 8906 70623276
Gastrointestinal fungal infection 34.42 10.93 21 296241 367 70631815
Out of specification test results 34.37 10.93 16 296246 156 70632026
Multiple-drug resistance 34.29 10.93 87 296175 7268 70624914
Feeling jittery 34.26 10.93 4 296258 11539 70620643
Metastases to meninges 34.18 10.93 53 296209 3083 70629099
Pneumonia bacterial 34.13 10.93 149 296113 16492 70615690
Therapeutic response decreased 34.08 10.93 384 295878 58069 70574113
Humoral immune defect 34.05 10.93 15 296247 127 70632055
Blood iron decreased 33.92 10.93 7 296255 13254 70618928
Diabetes mellitus inadequate control 33.75 10.93 27 296235 22618 70609564
Impaired work ability 33.70 10.93 13 296249 16327 70615855
Hyperlipidaemia 33.66 10.93 30 296232 23833 70608349
Leukaemic infiltration 33.65 10.93 15 296247 131 70632051
Lupus vasculitis 33.61 10.93 23 296239 493 70631689
BK polyomavirus test positive 33.58 10.93 14 296248 102 70632080
Skin mass 33.53 10.93 87 296175 7369 70624813
Gallbladder disorder 33.49 10.93 16 296246 17696 70614486
Coronavirus infection 33.47 10.93 78 296184 6174 70626008
Hepatic candidiasis 33.44 10.93 13 296249 77 70632105
Viral load increased 33.41 10.93 48 296214 2608 70629574
Babesiosis 33.36 10.93 20 296242 338 70631844
Creatinine renal clearance decreased 33.35 10.93 15 296247 17185 70614997
Central nervous system infection 33.27 10.93 33 296229 1208 70630974
Microangiopathic haemolytic anaemia 33.14 10.93 35 296227 1381 70630801
Dysplasia 33.13 10.93 33 296229 1214 70630968
Gas gangrene 32.99 10.93 18 296244 252 70631930
Encephalitis enteroviral 32.98 10.93 15 296247 138 70632044
Disseminated cryptococcosis 32.95 10.93 39 296223 1748 70630434
Stenotrophomonas infection 32.93 10.93 54 296208 3295 70628887
Mucosal toxicity 32.87 10.93 24 296238 572 70631610
Fungal sepsis 32.79 10.93 38 296224 1665 70630517
Morganella infection 32.73 10.93 31 296231 1071 70631111
Product storage error 32.70 10.93 10 296252 14531 70617651
Nasal cavity cancer 32.67 10.93 17 296245 215 70631967
Morphoea 32.61 10.93 21 296241 405 70631777
Lentigo 32.58 10.93 22 296240 461 70631721
Melaena 32.58 10.93 123 296139 56232 70575950
Heart rate irregular 32.54 10.93 46 296216 29697 70602485
Desmoplastic small round cell tumour 32.40 10.93 17 296245 219 70631963
Cytomegalovirus enteritis 32.34 10.93 26 296236 718 70631464
Osteolysis 32.28 10.93 55 296207 3464 70628718
Evans syndrome 32.26 10.93 21 296241 413 70631769
Post procedural infection 32.24 10.93 3 296259 10350 70621832
Pneumonia aspiration 32.21 10.93 142 296120 62147 70570035
Angina unstable 32.19 10.93 13 296249 15880 70616302
Human metapneumovirus test positive 32.07 10.93 15 296247 148 70632034
Haemolytic uraemic syndrome 32.04 10.93 60 296202 4070 70628112
Norovirus test positive 32.01 10.93 22 296240 475 70631707
Hepatic function abnormal 31.98 10.93 429 295833 67567 70564615
Atelectasis 31.97 10.93 219 296043 28743 70603439
Enteritis 31.96 10.93 122 296140 12709 70619473
Haematoma 31.83 10.93 100 296162 48318 70583864
Appendiceal abscess 31.79 10.93 18 296244 272 70631910
Non-Hodgkin's lymphoma 31.79 10.93 36 296226 1538 70630644
Glaucoma 31.75 10.93 18 296244 18074 70614108
Hypoalbuminaemia 31.74 10.93 161 296101 18961 70613221
Haemoglobin decreased 31.71 10.93 1100 295162 204059 70428123
Lymphadenopathy mediastinal 31.68 10.93 59 296203 3986 70628196
Sarcoma metastatic 31.50 10.93 13 296249 92 70632090
Fungal oesophagitis 31.47 10.93 27 296235 818 70631364
Hyperbilirubinaemia 31.36 10.93 181 296081 22387 70609795
Central nervous system enteroviral infection 31.31 10.93 12 296250 68 70632114
Ligament sprain 31.25 10.93 6 296256 11957 70620225
Glomerulonephritis rapidly progressive 31.24 10.93 34 296228 1389 70630793
Cardiac failure congestive 31.11 10.93 389 295873 135068 70497114
Ototoxicity 31.08 10.93 49 296213 2892 70629290
Angina pectoris 31.06 10.93 101 296161 48282 70583900
Hepatitis C RNA increased 31.05 10.93 20 296242 386 70631796
Disseminated mucormycosis 30.92 10.93 24 296238 629 70631553
Unresponsive to stimuli 30.90 10.93 112 296150 51819 70580363
Viral test positive 30.87 10.93 20 296242 390 70631792
Primary cardiac lymphoma 30.84 10.93 10 296252 31 70632151
Subdural hygroma 30.81 10.93 21 296241 447 70631735
Triple negative breast cancer 30.81 10.93 15 296247 163 70632019
Blindness 30.80 10.93 184 296078 23043 70609139
Disability 30.77 10.93 12 296250 14971 70617211
Lethargy 30.76 10.93 186 296076 75064 70557118
Secretion discharge 30.74 10.93 8 296254 12925 70619257
Eye disorder 30.70 10.93 25 296237 20760 70611422
Combined immunodeficiency 30.69 10.93 13 296249 99 70632083
Radiation skin injury 30.68 10.93 33 296229 1330 70630852
Psychomotor hyperactivity 30.65 10.93 13 296249 15420 70616762
Endocarditis bacterial 30.64 10.93 34 296228 1420 70630762
Angioimmunoblastic T-cell lymphoma 30.62 10.93 22 296240 511 70631671
Tardive dyskinesia 30.60 10.93 3 296259 9926 70622256
Disseminated toxoplasmosis 30.49 10.93 15 296247 167 70632015
Akathisia 30.40 10.93 7 296255 12286 70619896
Paraneoplastic pemphigus 30.30 10.93 14 296248 134 70632048
Coronary artery occlusion 30.28 10.93 11 296251 14334 70617848
Rubulavirus test positive 30.21 10.93 9 296253 19 70632163
Pulmonary mucormycosis 29.96 10.93 28 296234 951 70631231
Autoimmune lymphoproliferative syndrome 29.96 10.93 15 296247 174 70632008
Dermatitis contact 29.90 10.93 3 296259 9746 70622436
Clonal evolution 29.83 10.93 16 296246 216 70631966
Microangiopathy 29.83 10.93 36 296226 1647 70630535
Blood creatinine increased 29.80 10.93 419 295843 142582 70489600
Electrocardiogram abnormal 29.69 10.93 12 296250 14652 70617530
T-cell lymphoma stage IV 29.60 10.93 14 296248 142 70632040
Musculoskeletal disorder 29.52 10.93 24 296238 19947 70612235
Peripheral T-cell lymphoma unspecified stage IV 29.50 10.93 10 296252 37 70632145
Retching 29.36 10.93 15 296247 15964 70616218
Hypofibrinogenaemia 29.34 10.93 38 296224 1869 70630313
Enterobacter bacteraemia 29.27 10.93 23 296239 614 70631568
Gastric stenosis 29.22 10.93 13 296249 113 70632069
Erythropoiesis abnormal 29.21 10.93 20 296242 429 70631753
Pemphigoid 29.18 10.93 11 296251 14011 70618171
Microscopic polyangiitis 29.13 10.93 19 296243 375 70631807
Viral sinusitis 29.08 10.93 16 296246 228 70631954
Blood loss anaemia 28.95 10.93 12 296250 14429 70617753
Proteinuria 28.88 10.93 216 296046 29158 70603024
Choriocarcinoma 28.85 10.93 14 296248 151 70632031
Abscess bacterial 28.82 10.93 25 296237 769 70631413
Ill-defined disorder 28.79 10.93 124 296138 54617 70577565
Epstein Barr virus positive mucocutaneous ulcer 28.76 10.93 25 296237 771 70631411
Lumbosacral radiculoplexus neuropathy 28.75 10.93 11 296251 62 70632120
Pneumonia pseudomonal 28.69 10.93 66 296196 5180 70627002
Hypertensive crisis 28.66 10.93 23 296239 19239 70612943
Enterocolitis infectious 28.63 10.93 45 296217 2649 70629533
Streptococcal infection 28.62 10.93 85 296177 7786 70624396
Stenotrophomonas sepsis 28.61 10.93 14 296248 154 70632028
Perineal necrosis 28.54 10.93 13 296249 120 70632062
Carpal tunnel syndrome 28.49 10.93 18 296244 17039 70615143
Trichosporon infection 28.48 10.93 27 296235 934 70631248
Delayed engraftment 28.36 10.93 16 296246 240 70631942
Primary mediastinal large B-cell lymphoma 28.32 10.93 11 296251 65 70632117
Bone lesion 28.26 10.93 67 296195 5363 70626819
Immune thrombocytopenia 28.20 10.93 139 296123 16185 70615997
Chromaturia 28.19 10.93 34 296228 23494 70608688
IIIrd nerve paralysis 28.18 10.93 29 296233 1110 70631072
Lower respiratory tract infection 28.15 10.93 315 295947 111598 70520584
Acute kidney injury 28.13 10.93 1659 294603 472965 70159217
Human herpesvirus 6 infection reactivation 28.10 10.93 18 296244 344 70631838
Recall phenomenon 28.09 10.93 28 296234 1031 70631151
Primary mediastinal large B-cell lymphoma recurrent 28.04 10.93 11 296251 67 70632115
Hilar lymphadenopathy 27.94 10.93 34 296228 1569 70630613
Hyperferritinaemia 27.94 10.93 22 296240 589 70631593
Eating disorder 27.83 10.93 22 296240 18543 70613639
Ventricular tachycardia 27.81 10.93 70 296192 36353 70595829
Gastritis bacterial 27.57 10.93 17 296245 303 70631879
Cryoglobulinaemia 27.52 10.93 25 296237 818 70631364
Blindness cortical 27.48 10.93 26 296236 897 70631285
Leukoerythroblastosis 27.46 10.93 16 296246 256 70631926
Needle issue 27.43 10.93 6 296256 10909 70621273
Portal hypertension 27.41 10.93 74 296188 6418 70625764
Adenocarcinoma gastric 27.35 10.93 35 296227 1701 70630481
Aspiration bone marrow abnormal 27.30 10.93 13 296249 134 70632048
Necrotising gastritis 27.25 10.93 11 296251 73 70632109
Jugular vein thrombosis 27.15 10.93 55 296207 3955 70628227
Coeliac disease 27.14 10.93 3 296259 9030 70623152
Haemorrhagic stroke 27.05 10.93 5 296257 10237 70621945
Poor quality sleep 27.04 10.93 27 296235 20322 70611860
Acute erythroid leukaemia 27.03 10.93 16 296246 264 70631918
Mood swings 27.00 10.93 22 296240 18264 70613918
Hiatus hernia 27.00 10.93 29 296233 21105 70611077
Acute interstitial pneumonitis 26.99 10.93 28 296234 1082 70631100
Red blood cell schistocytes present 26.97 10.93 21 296241 553 70631629
Chronic graft versus host disease in intestine 26.95 10.93 17 296245 316 70631866
Left ventricular dilatation 26.94 10.93 27 296235 1001 70631181
Acute biphenotypic leukaemia 26.89 10.93 13 296249 139 70632043
Cellulitis gangrenous 26.87 10.93 16 296246 267 70631915
Transformation to acute myeloid leukaemia 26.87 10.93 26 296236 923 70631259
Central nervous system vasculitis 26.84 10.93 30 296232 1263 70630919
Rash erythematous 26.68 10.93 118 296144 51600 70580582
Blood urea increased 26.67 10.93 100 296162 45809 70586373
Burkitt's lymphoma 26.64 10.93 13 296249 142 70632040
Epstein-Barr virus test positive 26.61 10.93 27 296235 1016 70631166
Hyperviscosity syndrome 26.54 10.93 18 296244 380 70631802
Diverticulum 26.46 10.93 12 296250 13681 70618501
Antithrombin III decreased 26.46 10.93 19 296243 441 70631741
Paraplegia 26.41 10.93 60 296202 4670 70627512
Tooth fracture 26.38 10.93 6 296256 10621 70621561
Sinus bradycardia 26.38 10.93 36 296226 23587 70608595
Mucosal infection 26.35 10.93 19 296243 444 70631738
Hepatitis viral 26.30 10.93 26 296236 948 70631234
Fusobacterium infection 26.23 10.93 12 296250 112 70632070
Lennox-Gastaut syndrome 26.19 10.93 15 296247 232 70631950
Joint dislocation 26.16 10.93 14 296248 14517 70617665
Natural killer-cell leukaemia 26.14 10.93 12 296250 113 70632069
Metapneumovirus infection 26.11 10.93 32 296230 1488 70630694
Actinomycosis 26.09 10.93 26 296236 957 70631225
Dementia 26.08 10.93 33 296229 22332 70609850
Incorrect route of product administration 26.08 10.93 44 296218 26448 70605734
Hypoproteinaemia 26.07 10.93 51 296211 3575 70628607
B-lymphocyte count decreased 26.04 10.93 29 296233 1216 70630966
Disseminated aspergillosis 26.03 10.93 24 296238 801 70631381
Hepatosplenic candidiasis 26.00 10.93 20 296242 517 70631665
Cerebral venous sinus thrombosis 25.98 10.93 37 296225 1994 70630188
Splenic candidiasis 25.94 10.93 11 296251 84 70632098
Fracture 25.89 10.93 27 296235 19917 70612265
Intervertebral disc protrusion 25.85 10.93 31 296231 21472 70610710
Thinking abnormal 25.85 10.93 9 296253 12042 70620140
Metastases to the mediastinum 25.77 10.93 20 296242 524 70631658
Gastroenteritis viral 25.71 10.93 31 296231 21424 70610758
Meningoencephalitis viral 25.70 10.93 18 296244 401 70631781
Hydrothorax 25.68 10.93 30 296232 1326 70630856
Hypertransaminasaemia 25.63 10.93 89 296173 8854 70623328
Large intestine polyp 25.61 10.93 8 296254 11468 70620714
Eye irritation 25.53 10.93 22 296240 17766 70614416
Blood pressure systolic abnormal 25.44 10.93 11 296251 12898 70619284
Thymus enlargement 25.43 10.93 12 296250 121 70632061
Amenorrhoea 25.35 10.93 75 296187 6855 70625327
Osteomyelitis bacterial 25.35 10.93 19 296243 472 70631710
Cryptosporidiosis infection 25.30 10.93 22 296240 679 70631503
Quadriplegia 25.24 10.93 46 296216 3056 70629126
Post-depletion B-cell recovery 25.21 10.93 7 296255 10 70632172
Cholecystectomy 25.08 10.93 3 296259 8494 70623688
Hepatitis B DNA increased 25.05 10.93 22 296240 688 70631494
Drug eruption 24.97 10.93 83 296179 39413 70592769
Metastases to retroperitoneum 24.94 10.93 17 296245 362 70631820
Rotator cuff syndrome 24.86 10.93 11 296251 12723 70619459
Laryngitis fungal 24.84 10.93 12 296250 128 70632054
Platelet transfusion 24.79 10.93 37 296225 2081 70630101
Miosis 24.79 10.93 14 296248 14087 70618095
Hepatic infection fungal 24.76 10.93 14 296248 211 70631971
Vocal cord paralysis 24.73 10.93 39 296223 2302 70629880
Human rhinovirus test positive 24.73 10.93 18 296244 427 70631755
Large intestinal ulcer perforation 24.69 10.93 10 296252 67 70632115
Leukaemic infiltration extramedullary 24.67 10.93 13 296249 169 70632013
Metastases to muscle 24.65 10.93 16 296246 313 70631869
Acute lung injury 24.58 10.93 43 296219 2766 70629416
Mucoepidermoid carcinoma 24.57 10.93 10 296252 68 70632114
VIth nerve paresis 24.52 10.93 12 296250 132 70632050
Listeriosis 24.51 10.93 36 296226 1996 70630186
Epidermal necrosis 24.48 10.93 30 296232 1395 70630787
Parkinsonism 24.48 10.93 17 296245 15308 70616874
Chromosome analysis abnormal 24.47 10.93 14 296248 216 70631966
Executive dysfunction 24.44 10.93 15 296247 265 70631917
Medulloblastoma recurrent 24.44 10.93 12 296250 133 70632049
Citrobacter bacteraemia 24.44 10.93 7 296255 12 70632170
Oroantral fistula 24.42 10.93 17 296245 375 70631807
Transaminases increased 24.37 10.93 302 295960 46716 70585466
Tinnitus 24.29 10.93 74 296188 36102 70596080
Tooth disorder 24.28 10.93 39 296223 23899 70608283
Seasonal allergy 24.27 10.93 13 296249 13471 70618711
Peripheral sensorimotor neuropathy 24.25 10.93 42 296220 2680 70629502
Computerised tomogram thorax 24.19 10.93 14 296248 221 70631961
Pneumaturia 24.17 10.93 8 296254 27 70632155
H1N1 influenza 24.13 10.93 39 296223 2351 70629831
Product dispensing error 24.03 10.93 10 296252 11998 70620184
Device breakage 23.95 10.93 5 296257 9393 70622789
Capnocytophaga infection 23.85 10.93 10 296252 74 70632108
Ovarian disorder 23.78 10.93 18 296244 454 70631728
Disorientation 23.76 10.93 143 296119 57780 70574402
Listeria sepsis 23.75 10.93 21 296241 663 70631519
Abdominal neoplasm 23.75 10.93 18 296244 455 70631727
T-cell prolymphocytic leukaemia 23.74 10.93 10 296252 75 70632107
Thirst 23.73 10.93 16 296246 14633 70617549
Molluscum contagiosum 23.68 10.93 18 296244 457 70631725
Diffuse large B-cell lymphoma stage II 23.65 10.93 11 296251 107 70632075
Joint effusion 23.64 10.93 18 296244 15459 70616723
Internal haemorrhage 23.63 10.93 3 296259 8113 70624069
Geotrichum infection 23.60 10.93 25 296237 990 70631192
Haemolytic anaemia 23.54 10.93 135 296127 16659 70615523
Diverticulitis 23.53 10.93 92 296170 41642 70590540
Nasal abscess 23.47 10.93 12 296250 146 70632036
Embolism 23.44 10.93 112 296150 12876 70619306
Emotional disorder 23.44 10.93 13 296249 13213 70618969
Neoplasm 23.42 10.93 79 296183 7745 70624437
Acute generalised exanthematous pustulosis 23.40 10.93 18 296244 15379 70616803
Ependymoma 23.39 10.93 11 296251 110 70632072
Lip dry 23.36 10.93 6 296256 9779 70622403
Metastatic malignant melanoma 23.35 10.93 45 296217 3119 70629063
Hair texture abnormal 23.19 10.93 45 296217 3135 70629047
Infection in an immunocompromised host 23.18 10.93 26 296236 1099 70631083
Achromobacter infection 23.13 10.93 11 296251 113 70632069
Scar 23.01 10.93 15 296247 13966 70618216
Gliosis 23.01 10.93 17 296245 413 70631769
Nail pigmentation 23.00 10.93 15 296247 296 70631886
Acinetobacter infection 22.97 10.93 40 296222 2564 70629618
Night sweats 22.94 10.93 99 296163 43585 70588597
Herpes oesophagitis 22.90 10.93 16 296246 355 70631827
Toxic neuropathy 22.90 10.93 23 296239 855 70631327
Anaphylactic shock 22.87 10.93 65 296197 32425 70599757
Vasculitis 22.85 10.93 150 296112 19408 70612774
Leukaemic lymphoma 22.77 10.93 10 296252 84 70632098
Facial paresis 22.76 10.93 59 296203 4994 70627188
Superior vena cava syndrome 22.75 10.93 26 296236 1122 70631060
Lymphadenitis 22.74 10.93 52 296210 4065 70628117
PIK3CA-activated mutation 22.73 10.93 19 296243 555 70631627
Palatal ulcer 22.64 10.93 11 296251 119 70632063
Hair follicle tumour benign 22.62 10.93 17 296245 424 70631758
Mediastinum neoplasm 22.57 10.93 10 296252 86 70632096
Diffuse large B-cell lymphoma stage III 22.56 10.93 11 296251 120 70632062
Blood glucose abnormal 22.55 10.93 6 296256 9551 70622631
Post-acute COVID-19 syndrome 22.53 10.93 13 296249 204 70631978
Blood pressure abnormal 22.49 10.93 19 296243 15495 70616687
Lupus-like syndrome 22.39 10.93 10 296252 11505 70620677
Body height decreased 22.36 10.93 3 296259 7780 70624402
Myelodysplastic syndrome transformation 22.31 10.93 20 296242 643 70631539
Autologous haematopoietic stem cell transplant 22.28 10.93 6 296256 7 70632175
Musculoskeletal discomfort 22.20 10.93 25 296237 17807 70614375
Hepatic lesion 22.19 10.93 66 296196 6051 70626131
Marrow hyperplasia 22.18 10.93 29 296233 1440 70630742
Vascular injury 22.15 10.93 25 296237 1064 70631118
Hepatitis B surface antigen positive 22.12 10.93 12 296250 166 70632016
Inflammatory myofibroblastic tumour 22.12 10.93 12 296250 166 70632016
Feeling cold 22.06 10.93 46 296216 25524 70606658
Skin abrasion 21.98 10.93 12 296250 12305 70619877
Cytomegalovirus enterocolitis 21.96 10.93 29 296233 1454 70630728
Cardiac amyloidosis 21.95 10.93 30 296232 1555 70630627
Skin irritation 21.95 10.93 7 296255 9902 70622280
Immunodeficiency common variable 21.92 10.93 14 296248 266 70631916
Laboratory test abnormal 21.82 10.93 47 296215 25776 70606406
Pharyngeal oedema 21.82 10.93 20 296242 15676 70616506
Sputum discoloured 21.79 10.93 28 296234 18823 70613359
Meningitis enteroviral 21.77 10.93 9 296253 64 70632118
T-cell lymphoma recurrent 21.77 10.93 9 296253 64 70632118
Pneumonia parainfluenzae viral 21.65 10.93 14 296248 272 70631910
Rhabdomyosarcoma 21.63 10.93 12 296250 174 70632008
Pain in jaw 21.62 10.93 98 296164 42571 70589611
Oropharyngeal pain 21.58 10.93 278 295984 96032 70536150
Oral disorder 21.56 10.93 86 296176 9143 70623039
Rib fracture 21.55 10.93 46 296216 25310 70606872
Gastroenteritis norovirus 21.52 10.93 41 296221 2818 70629364
Corynebacterium infection 21.42 10.93 25 296237 1104 70631078
Oligohydramnios 21.41 10.93 44 296218 3196 70628986
Head discomfort 21.40 10.93 14 296248 13009 70619173
Macular degeneration 21.40 10.93 3 296259 7525 70624657
Coma scale abnormal 21.35 10.93 4 296258 8112 70624070
Intussusception 21.35 10.93 23 296239 929 70631253
Accidental exposure to product 21.34 10.93 54 296208 27997 70604185
Precursor B-lymphoblastic lymphoma recurrent 21.29 10.93 7 296255 23 70632159
Thyroid dermatopathy 21.29 10.93 7 296255 23 70632159
Respiratory tract infection bacterial 21.28 10.93 31 296231 1706 70630476
Dyspnoea exertional 21.24 10.93 217 296045 78213 70553969
Pleural mass 21.19 10.93 9 296253 69 70632113
Dysstasia 21.14 10.93 46 296216 25133 70607049
Blood urine present 21.10 10.93 30 296232 19323 70612859
Ear pain 21.10 10.93 53 296209 27546 70604636
Miller Fisher syndrome 21.10 10.93 12 296250 183 70631999
Metastases to diaphragm 21.07 10.93 8 296254 44 70632138
Hair colour changes 21.06 10.93 49 296213 3874 70628308
CD4 lymphocytes decreased 20.98 10.93 38 296224 2513 70629669
Cutaneous T-cell lymphoma 20.95 10.93 38 296224 2515 70629667
Cerebral fungal infection 20.93 10.93 15 296247 347 70631835
Tuberculosis of central nervous system 20.90 10.93 18 296244 548 70631634
Necrosis 20.89 10.93 81 296181 8500 70623682
Obstructive airways disorder 20.87 10.93 49 296213 26064 70606118
Depressed level of consciousness 20.86 10.93 249 296013 87182 70545000
Blood immunoglobulin A decreased 20.83 10.93 19 296243 625 70631557
Rhinorrhoea 20.83 10.93 177 296085 66194 70565988
Eosinophilia 20.80 10.93 92 296170 40227 70591955
Pneumonia viral 20.78 10.93 79 296183 8213 70623969
Bone density decreased 20.74 10.93 11 296251 11463 70620719
Lung consolidation 20.71 10.93 79 296183 8227 70623955
Bordetella infection 20.68 10.93 10 296252 107 70632075
Lymphoplasmacytoid lymphoma/immunocytoma 20.63 10.93 8 296254 47 70632135
Blood thyroid stimulating hormone increased 20.63 10.93 5 296257 8474 70623708
Laryngitis 20.63 10.93 16 296246 13615 70618567
Cerebral salt-wasting syndrome 20.59 10.93 10 296252 108 70632074
Pneumothorax 20.50 10.93 181 296081 25665 70606517
Blood bilirubin increased 20.48 10.93 358 295904 59543 70572639
Ketoacidosis 20.42 10.93 3 296259 7266 70624916
Metastases to chest wall 20.40 10.93 16 296246 426 70631756
Enteral nutrition 20.36 10.93 8 296254 49 70632133
Acute megakaryocytic leukaemia 20.36 10.93 8 296254 49 70632133
Bone erosion 20.31 10.93 20 296242 15153 70617029
Optic atrophy 20.24 10.93 31 296231 1784 70630398
Speech disorder 20.16 10.93 126 296136 50454 70581728
Abnormal loss of weight 20.13 10.93 4 296258 7780 70624402
Atypical haemolytic uraemic syndrome 20.13 10.93 21 296241 817 70631365
Campylobacter gastroenteritis 20.07 10.93 25 296237 1182 70631000
Pelvic fracture 20.06 10.93 11 296251 11250 70620932
Cytokine storm 20.02 10.93 22 296240 909 70631273
Cholangiocarcinoma 20.01 10.93 36 296226 2368 70629814
Inflammation 19.95 10.93 221 296041 78444 70553738
Dysgeusia 19.89 10.93 123 296139 49379 70582803
Neurological decompensation 19.87 10.93 54 296208 4702 70627480
Coronary artery stenosis 19.85 10.93 12 296250 11632 70620550
Salivary hypersecretion 19.78 10.93 15 296247 12910 70619272
Clear cell renal cell carcinoma 19.75 10.93 35 296227 2275 70629907
Oesophagitis 19.74 10.93 162 296100 22490 70609692
Metastases to peritoneum 19.74 10.93 47 296215 3772 70628410
Ureaplasma infection 19.72 10.93 20 296242 752 70631430
Disturbance in attention 19.72 10.93 102 296160 42792 70589390
Stevens-Johnson syndrome 19.71 10.93 80 296182 35827 70596355
Peripheral venous disease 19.68 10.93 10 296252 10677 70621505
Carotid intima-media thickness increased 19.67 10.93 9 296253 84 70632098
Herpes zoster cutaneous disseminated 19.65 10.93 16 296246 450 70631732
Unintentional medical device removal 19.64 10.93 70 296192 7054 70625128
Peritonitis viral 19.58 10.93 8 296254 55 70632127
Muscle strain 19.57 10.93 6 296256 8704 70623478
Alternaria infection 19.56 10.93 18 296244 599 70631583
Cardiac cirrhosis 19.55 10.93 12 296250 212 70631970
Vasogenic cerebral oedema 19.55 10.93 24 296238 1118 70631064
Full blood count abnormal 19.54 10.93 74 296188 33804 70598378
Alopecia totalis 19.53 10.93 14 296248 324 70631858
Electrocardiogram ST segment elevation 19.48 10.93 4 296258 7600 70624582
Human herpesvirus 7 infection 19.46 10.93 10 296252 123 70632059
Lung diffusion test decreased 19.46 10.93 25 296237 1220 70630962
Cryptococcal fungaemia 19.44 10.93 11 296251 166 70632016
Injection site induration 19.40 10.93 7 296255 9161 70623021
Lymphomatoid papulosis 19.38 10.93 14 296248 328 70631854
Hemianopia 19.36 10.93 29 296233 1636 70630546
Extramedullary haemopoiesis 19.32 10.93 10 296252 125 70632057
Marginal zone lymphoma recurrent 19.31 10.93 7 296255 33 70632149
Cerebellar haemangioma 19.31 10.93 9 296253 88 70632094
Pneumococcal infection 19.16 10.93 21 296241 865 70631317
Low density lipoprotein increased 19.15 10.93 5 296257 8060 70624122
Herpes zoster meningoencephalitis 19.14 10.93 19 296243 696 70631486
CSF protein increased 19.05 10.93 24 296238 1148 70631034
Diaphragm muscle weakness 19.04 10.93 11 296251 173 70632009
Stomatococcal infection 19.02 10.93 13 296249 278 70631904
Renal cancer 18.95 10.93 13 296249 11783 70620399
Drug level increased 18.94 10.93 83 296179 36386 70595796
Anaplastic large cell lymphoma T- and null-cell types 18.93 10.93 11 296251 175 70632007
Ewing's sarcoma recurrent 18.90 10.93 6 296256 17 70632165
Small intestinal perforation 18.88 10.93 40 296222 2969 70629213
Walking aid user 18.85 10.93 5 296257 7976 70624206
Muscle tightness 18.85 10.93 13 296249 11749 70620433
Metastases to eye 18.84 10.93 12 296250 227 70631955
Mesenteric abscess 18.78 10.93 10 296252 133 70632049
Blastic plasmacytoid dendritic cell neoplasia 18.78 10.93 10 296252 133 70632049
Respiratory tract infection viral 18.76 10.93 44 296218 3497 70628685
Prostatic specific antigen increased 18.76 10.93 8 296254 9458 70622724
Ameloblastoma 18.71 10.93 9 296253 95 70632087
Retinitis viral 18.71 10.93 10 296252 134 70632048
Mydriasis 18.67 10.93 24 296238 16129 70616053
Superior sagittal sinus thrombosis 18.66 10.93 22 296240 982 70631200
Paranoia 18.65 10.93 27 296235 17261 70614921
Meningitis tuberculous 18.65 10.93 24 296238 1173 70631009
Hepatic amoebiasis 18.63 10.93 9 296253 96 70632086
Positron emission tomogram abnormal 18.63 10.93 13 296249 288 70631894
Hepatic calcification 18.60 10.93 14 296248 350 70631832
Osteonecrosis of jaw 18.59 10.93 257 296005 40745 70591437
Atrioventricular block first degree 18.58 10.93 13 296249 11660 70620522
Upper limb fracture 18.57 10.93 24 296238 16095 70616087
Myositis 18.57 10.93 131 296131 17358 70614824
Ocular lymphoma 18.55 10.93 9 296253 97 70632085
Intestinal atresia 18.55 10.93 8 296254 64 70632118
Karyotype analysis abnormal 18.51 10.93 7 296255 38 70632144
Bone sarcoma 18.39 10.93 9 296253 99 70632083
Platelet count abnormal 18.39 10.93 50 296212 4355 70627827
Splenic marginal zone lymphoma 18.36 10.93 7 296255 39 70632143
Viral cardiomyopathy 18.36 10.93 7 296255 39 70632143
VIth nerve paralysis 18.33 10.93 27 296235 1501 70630681
Haemolysis 18.30 10.93 96 296166 11455 70620727
Primary immunodeficiency syndrome 18.23 10.93 8 296254 67 70632115
Sexual dysfunction 18.22 10.93 3 296259 6678 70625504
T-lymphocyte count decreased 18.20 10.93 16 296246 501 70631681
Mycobacterium kansasii infection 18.13 10.93 14 296248 364 70631818
Viral sepsis 18.08 10.93 10 296252 144 70632038
Tenosynovitis 18.05 10.93 19 296243 13957 70618225
Kaposi's sarcoma 18.05 10.93 19 296243 747 70631435
Hemiparesis 18.01 10.93 206 296056 31263 70600919
Disseminated cytomegaloviral infection 17.95 10.93 15 296247 438 70631744
Inappropriate antidiuretic hormone secretion 17.95 10.93 162 296100 23114 70609068
Adenoviral upper respiratory infection 17.93 10.93 4 296258 0 70632182
Hypercholesterolaemia 17.92 10.93 30 296232 18087 70614095
Cushingoid 17.89 10.93 76 296186 8312 70623870
Intracardiac thrombus 17.84 10.93 46 296216 3881 70628301
Arteritis 17.84 10.93 20 296242 845 70631337
Neuroendocrine carcinoma of the skin 17.79 10.93 23 296239 1129 70631053
Herpes simplex reactivation 17.75 10.93 14 296248 376 70631806
Metastatic neoplasm 17.67 10.93 51 296211 4597 70627585
CD4/CD8 ratio decreased 17.66 10.93 7 296255 44 70632138
Ischaemic cardiomyopathy 17.66 10.93 4 296258 7100 70625082
Drug level decreased 17.65 10.93 16 296246 12608 70619574
Myoclonus 17.63 10.93 54 296208 26301 70605881
Peripheral vascular disorder 17.62 10.93 5 296257 7627 70624555
Philadelphia positive acute lymphocytic leukaemia 17.61 10.93 10 296252 152 70632030
Liver function test increased 17.60 10.93 77 296185 33770 70598412
Pharyngeal inflammation 17.57 10.93 21 296241 951 70631231
Metastases to spine 17.55 10.93 45 296217 3784 70628398
Germ cell cancer 17.49 10.93 10 296252 154 70632028
Transplant dysfunction 17.46 10.93 66 296196 6843 70625339
Cranial nerve disorder 17.44 10.93 22 296240 1054 70631128
Leukonychia 17.40 10.93 7 296255 46 70632136
Haematocolpos 17.40 10.93 7 296255 46 70632136
Liver scan abnormal 17.40 10.93 7 296255 46 70632136
Enterovirus test positive 17.38 10.93 12 296250 261 70631921
Decreased appetite 17.37 10.93 1069 295193 303711 70328471
Tooth hypoplasia 17.37 10.93 11 296251 206 70631976
Photosensitivity reaction 17.36 10.93 34 296228 19306 70612876
Central nervous system mass 17.35 10.93 9 296253 113 70632069
Skin fissures 17.35 10.93 13 296249 11257 70620925
Helicobacter sepsis 17.34 10.93 6 296256 24 70632158
Rhabdoid tumour 17.34 10.93 6 296256 24 70632158
Enterovesical fistula 17.32 10.93 22 296240 1061 70631121
Radiation necrosis 17.31 10.93 14 296248 390 70631792
Brain stem syndrome 17.31 10.93 19 296243 784 70631398
Post lumbar puncture syndrome 17.30 10.93 18 296244 698 70631484
Tooth development disorder 17.27 10.93 7 296255 47 70632135
Paresis 17.24 10.93 45 296217 3825 70628357
Mucosal disorder 17.23 10.93 40 296222 3158 70629024
Xanthogranuloma 17.19 10.93 8 296254 78 70632104
Post procedural haemorrhage 17.18 10.93 17 296245 12849 70619333
Pharyngitis streptococcal 17.16 10.93 9 296253 9439 70622743
Non-Hodgkin's lymphoma recurrent 17.15 10.93 6 296256 25 70632157
Spinal cord disorder 17.14 10.93 28 296234 1703 70630479
Ventricular dysfunction 17.14 10.93 57 296205 5547 70626635
Erythropenia 17.10 10.93 14 296248 397 70631785
Lymphocytic leukaemia 17.09 10.93 11 296251 212 70631970
Herpes simplex viraemia 17.07 10.93 12 296250 269 70631913
Hydrocephalus 17.05 10.93 73 296189 8012 70624170
Neurofibrosarcoma 17.05 10.93 11 296251 213 70631969
Streptococcal sepsis 17.02 10.93 34 296228 2420 70629762
Blood pressure diastolic increased 16.98 10.93 16 296246 12375 70619807
Arteriosclerosis 16.97 10.93 27 296235 16611 70615571
Precursor T-lymphoblastic lymphoma/leukaemia recurrent 16.96 10.93 5 296257 10 70632172
Lymphoplasmacytoid lymphoma/immunocytoma recurrent 16.96 10.93 5 296257 10 70632172
Faeces soft 16.96 10.93 4 296258 6906 70625276
Myocardial oedema 16.90 10.93 13 296249 336 70631846
Peripheral T-cell lymphoma unspecified stage III 16.79 10.93 7 296255 51 70632131
Trichodysplasia spinulosa 16.79 10.93 18 296244 723 70631459
Follicular lymphoma 16.77 10.93 12 296250 277 70631905
Paranasal sinus mucosal hypertrophy 16.75 10.93 8 296254 83 70632099
B-cell lymphoma stage IV 16.75 10.93 8 296254 83 70632099
Tumour necrosis 16.72 10.93 28 296234 1739 70630443
Soft tissue neoplasm 16.67 10.93 8 296254 84 70632098
Hepatic necrosis 16.67 10.93 76 296186 8570 70623612
Cyanosis 16.65 10.93 46 296216 23160 70609022
Glottis carcinoma 16.64 10.93 5 296257 11 70632171
Fungal test positive 16.61 10.93 21 296241 1008 70631174
Enteropathy-associated T-cell lymphoma 16.60 10.93 6 296256 28 70632154
Drug clearance decreased 16.58 10.93 38 296224 2975 70629207
Disorder of orbit 16.56 10.93 9 296253 125 70632057
Perineal infection 16.55 10.93 18 296244 735 70631447
Scleroderma renal crisis 16.52 10.93 14 296248 417 70631765
Vomiting 16.51 10.93 2198 294064 590913 70041269
Malnutrition 16.49 10.93 143 296119 20174 70612008
Deformity 16.46 10.93 7 296255 8290 70623892
Increased tendency to bruise 16.45 10.93 10 296252 9665 70622517
Frustration tolerance decreased 16.44 10.93 4 296258 6761 70625421
Spinal disorder 16.43 10.93 9 296253 9211 70622971
Lupus myocarditis 16.43 10.93 8 296254 87 70632095
Paratracheal lymphadenopathy 16.43 10.93 10 296252 174 70632008
Pneumonitis chemical 16.42 10.93 13 296249 351 70631831
Acute pulmonary oedema 16.37 10.93 104 296158 13308 70618874
Jejunal stenosis 16.35 10.93 8 296254 88 70632094
Li-Fraumeni syndrome 16.34 10.93 5 296257 12 70632170
Acute polyneuropathy 16.32 10.93 14 296248 424 70631758
Retinal toxicity 16.32 10.93 24 296238 1332 70630850
Haematemesis 16.28 10.93 128 296134 48669 70583513
Cytomegalovirus urinary tract infection 16.27 10.93 6 296256 30 70632152
Growth retardation 16.26 10.93 27 296235 1665 70630517
Drug level above therapeutic 16.23 10.93 6 296256 7736 70624446
Arterial occlusive disease 16.23 10.93 6 296256 7736 70624446
Inflammatory pseudotumour 16.23 10.93 7 296255 56 70632126
Anorectal cellulitis 16.19 10.93 8 296254 90 70632092
CSF test abnormal 16.13 10.93 15 296247 506 70631676
Double hit lymphoma 16.12 10.93 7 296255 57 70632125
Breast cancer stage I 16.07 10.93 3 296259 6099 70626083
Brain oedema 16.07 10.93 159 296103 23259 70608923
Borrelia infection 16.07 10.93 11 296251 236 70631946
Autologous bone marrow transplantation therapy 16.06 10.93 5 296257 13 70632169
Urinary retention 16.06 10.93 141 296121 52379 70579803
Basal ganglion degeneration 16.05 10.93 14 296248 434 70631748
Incorrect product administration duration 16.01 10.93 13 296249 10811 70621371
Blood immunoglobulin G decreased 15.99 10.93 37 296225 2915 70629267
Groin pain 15.97 10.93 16 296246 12026 70620156
Meningitis enterococcal 15.96 10.93 8 296254 93 70632089
Hippocampal sclerosis 15.95 10.93 9 296253 135 70632047
Bradyphrenia 15.93 10.93 11 296251 9935 70622247
Cutaneous T-cell lymphoma recurrent 15.92 10.93 7 296255 59 70632123
Breast cancer 15.91 10.93 212 296050 33337 70598845
Large intestine perforation 15.91 10.93 102 296160 13093 70619089
Peliosis hepatis 15.89 10.93 8 296254 94 70632088
Renal failure 15.87 10.93 953 295309 188117 70444065
Mucocutaneous haemorrhage 15.85 10.93 10 296252 186 70631996
Erectile dysfunction 15.83 10.93 20 296242 13542 70618640
Basophilia 15.80 10.93 6 296256 33 70632149
Hepatic infarction 15.78 10.93 19 296243 867 70631315
Dermatitis atopic 15.75 10.93 9 296253 8998 70623184
Paraesthesia oral 15.74 10.93 25 296237 15392 70616790
Viral skin infection 15.74 10.93 8 296254 96 70632086
Blood potassium decreased 15.73 10.93 108 296154 42313 70589869
Acanthamoeba infection 15.70 10.93 15 296247 524 70631658
Sarcoidosis 15.68 10.93 62 296200 6565 70625617
Splenic necrosis 15.60 10.93 8 296254 98 70632084
Vitamin B12 deficiency 15.59 10.93 3 296259 5969 70626213
Drug tolerance decreased 15.58 10.93 11 296251 9822 70622360
Neuromuscular toxicity 15.57 10.93 10 296252 192 70631990
Papilloedema 15.56 10.93 57 296205 5821 70626361
Renal amyloidosis 15.55 10.93 9 296253 142 70632040
Viral vasculitis 15.55 10.93 9 296253 142 70632040
Chronic hepatitis 15.55 10.93 23 296239 1283 70630899
Meningeal neoplasm 15.54 10.93 5 296257 15 70632167
Mediastinal mass 15.54 10.93 15 296247 531 70631651
Familial haemophagocytic lymphohistiocytosis 15.52 10.93 7 296255 63 70632119
Joint neoplasm 15.52 10.93 7 296255 63 70632119
Sluggishness 15.49 10.93 3 296259 5940 70626242
Soft tissue infection 15.48 10.93 41 296221 3516 70628666
Transitional cell carcinoma 15.38 10.93 32 296230 2345 70629837
Skin burning sensation 15.37 10.93 15 296247 11411 70620771
Sinus polyp 15.37 10.93 14 296248 460 70631722
Vitamin D decreased 15.35 10.93 8 296254 8419 70623763
Arrhythmia 15.34 10.93 155 296107 55988 70576194
Metastases to uterus 15.33 10.93 7 296255 65 70632117
Sphingomonas paucimobilis infection 15.32 10.93 8 296254 102 70632080
Tracheo-oesophageal fistula 15.31 10.93 15 296247 541 70631641
Infusion site streaking 15.29 10.93 14 296248 463 70631719
Rhinitis allergic 15.26 10.93 10 296252 9285 70622897
Cardiac murmur 15.26 10.93 17 296245 12169 70620013
Haemorrhage 15.26 10.93 252 296010 83563 70548619
Granulicatella infection 15.24 10.93 7 296255 66 70632116
Hepatitis B e antigen positive 15.23 10.93 6 296256 37 70632145
Lymphangiosis carcinomatosa 15.23 10.93 28 296234 1873 70630309
Ovarian cyst 15.21 10.93 16 296246 11756 70620426
Intentional dose omission 15.21 10.93 5 296257 6936 70625246
Occult blood positive 15.18 10.93 4 296258 6409 70625773
Myelofibrosis 15.17 10.93 33 296229 2494 70629688
Periostitis 15.17 10.93 15 296247 547 70631635
Systolic dysfunction 15.17 10.93 40 296222 3421 70628761
Eye infection 15.16 10.93 12 296250 10106 70622076
Aphonia 15.13 10.93 10 296252 9241 70622941
Metastases to heart 15.11 10.93 11 296251 261 70631921
Hepatitis 15.09 10.93 293 295969 49687 70582495
Pancreatic carcinoma 15.09 10.93 19 296243 12885 70619297
Adult T-cell lymphoma/leukaemia recurrent 15.08 10.93 5 296257 17 70632165
Subacute combined cord degeneration 15.06 10.93 12 296250 327 70631855
SARS-CoV-2 test negative 15.06 10.93 16 296246 636 70631546
Urinary bladder rupture 15.05 10.93 8 296254 106 70632076
Foetal growth restriction 15.04 10.93 28 296234 1891 70630291
Ulcer 15.02 10.93 56 296206 25698 70606484
Juvenile idiopathic arthritis 14.96 10.93 3 296259 5797 70626385
Post procedural complication 14.94 10.93 45 296217 22036 70610146
Synovial cyst 14.91 10.93 9 296253 8733 70623449
Mitral valve incompetence 14.86 10.93 174 296088 26554 70605628
Gait apraxia 14.86 10.93 5 296257 18 70632164
Chronic cutaneous lupus erythematosus 14.75 10.93 12 296250 337 70631845
Light chain analysis increased 14.75 10.93 24 296238 1455 70630727
Hepatic cirrhosis 14.74 10.93 72 296190 30659 70601523
Exophthalmos 14.74 10.93 25 296237 1569 70630613
Carotid artery stenosis 14.73 10.93 8 296254 8228 70623954
Mucocutaneous ulceration 14.72 10.93 12 296250 338 70631844
Fibrosarcoma 14.72 10.93 6 296256 41 70632141
Transient hypogammaglobulinaemia of infancy 14.72 10.93 6 296256 41 70632141
Embryonal rhabdomyosarcoma 14.71 10.93 7 296255 72 70632110
Intervertebral disc degeneration 14.71 10.93 22 296240 13878 70618304
Hypouricaemia 14.71 10.93 13 296249 410 70631772
Squamous cell carcinoma 14.70 10.93 108 296154 14496 70617686
Weight fluctuation 14.69 10.93 11 296251 9530 70622652
Neurological symptom 14.64 10.93 66 296196 7407 70624775
POEMS syndrome 14.59 10.93 6 296256 42 70632140
Atypical teratoid/rhabdoid tumour of CNS 14.59 10.93 6 296256 42 70632140
Mucosal erosion 14.56 10.93 29 296233 2060 70630122
Ankle brachial index decreased 14.55 10.93 7 296255 74 70632108
Citrobacter sepsis 14.55 10.93 7 296255 74 70632108
Cerebrosclerosis 14.45 10.93 5 296257 20 70632162
Viral infection 14.42 10.93 233 296029 38158 70594024
Histiocytic sarcoma 14.42 10.93 8 296254 116 70632066
Neuroborreliosis 14.42 10.93 8 296254 116 70632066
Adverse reaction 14.41 10.93 9 296253 8573 70623609
Septic embolus 14.40 10.93 27 296235 1833 70630349
Citrobacter infection 14.40 10.93 18 296244 854 70631328
Hodgkin's disease 14.39 10.93 18 296244 855 70631327
Lung adenocarcinoma 14.38 10.93 67 296195 7623 70624559
Hepatic vein occlusion 14.37 10.93 9 296253 165 70632017
B-cell small lymphocytic lymphoma 14.37 10.93 9 296253 165 70632017
Dizziness postural 14.37 10.93 13 296249 10255 70621927
Pulmonary haemosiderosis 14.36 10.93 6 296256 44 70632138
Facial paralysis 14.33 10.93 136 296126 19672 70612510
Device malfunction 14.32 10.93 37 296225 19047 70613135
Glomerulosclerosis 14.31 10.93 19 296243 958 70631224
Pulse waveform abnormal 14.30 10.93 7 296255 77 70632105
Polyp 14.30 10.93 6 296256 7164 70625018
Lymph node fibrosis 14.29 10.93 4 296258 6 70632176
Reproductive toxicity 14.29 10.93 4 296258 6 70632176
Renal pain 14.26 10.93 7 296255 7623 70624559
Glomerular filtration rate decreased 14.26 10.93 42 296220 20714 70611468
Gastric pneumatosis 14.26 10.93 5 296257 21 70632161
Cord blood transplant therapy 14.24 10.93 6 296256 45 70632137
Blood pressure inadequately controlled 14.20 10.93 3 296259 5589 70626593
Cholecystitis chronic 14.20 10.93 11 296251 9365 70622817
Increased appetite 14.20 10.93 14 296248 10599 70621583
Medulloblastoma 14.18 10.93 8 296254 120 70632062
Pleural neoplasm 14.17 10.93 12 296250 357 70631825
Hereditary motor and sensory neuropathy 14.12 10.93 8 296254 121 70632061
Mantle cell lymphoma stage IV 14.12 10.93 8 296254 121 70632061
Respiratory rate increased 14.11 10.93 39 296223 19633 70612549
Gastrointestinal motility disorder 14.11 10.93 3 296259 5563 70626619
Pyloric stenosis 14.10 10.93 13 296249 434 70631748
Blood triglycerides increased 14.09 10.93 39 296223 19625 70612557
Follicular mucinosis 14.07 10.93 5 296257 22 70632160
Cytotoxic oedema 14.06 10.93 12 296250 361 70631821
Candida endophthalmitis 14.05 10.93 9 296253 172 70632010
Intraocular pressure increased 14.05 10.93 10 296252 8891 70623291
Adenocarcinoma of colon 14.04 10.93 52 296210 5340 70626842
Hypomania 13.98 10.93 4 296258 6068 70626114
Personality change 13.95 10.93 10 296252 8860 70623322
Necrotising retinitis 13.95 10.93 21 296241 1190 70630992
Tongue disorder 13.94 10.93 21 296241 13206 70618976
Hepatitis D 13.92 10.93 7 296255 82 70632100
Thymic cancer metastatic 13.91 10.93 4 296258 7 70632175
Bacterial translocation 13.90 10.93 14 296248 522 70631660
Apraxia 13.85 10.93 33 296229 2650 70629532
Prostatic abscess 13.81 10.93 12 296250 370 70631812
Conus medullaris syndrome 13.81 10.93 6 296256 49 70632133
Sleep disorder due to a general medical condition 13.80 10.93 14 296248 10462 70621720
Metastases to abdominal cavity 13.79 10.93 14 296248 527 70631655
Productive cough 13.78 10.93 237 296025 78100 70554082
Primary effusion lymphoma 13.77 10.93 7 296255 84 70632098
Abdominal compartment syndrome 13.76 10.93 23 296239 1426 70630756
Generalised oedema 13.75 10.93 145 296117 21563 70610619
Blast cell count increased 13.75 10.93 22 296240 1315 70630867
Pneumonia measles 13.72 10.93 5 296257 24 70632158
Bronchiolitis 13.69 10.93 41 296221 3773 70628409
Gastric perforation 13.68 10.93 41 296221 3774 70628408
Jaw operation 13.68 10.93 17 296245 802 70631380
Pulmonary thrombosis 13.64 10.93 16 296246 11192 70620990
Gastrointestinal inflammation 13.64 10.93 60 296202 6663 70625519
Chromosomal deletion 13.63 10.93 7 296255 86 70632096
Premature ageing 13.63 10.93 7 296255 86 70632096
Aplasia pure red cell 13.61 10.93 64 296198 7310 70624872
Tongue fungal infection 13.60 10.93 6 296256 51 70632131
Abdominal pain lower 13.59 10.93 66 296196 28150 70604032
Aortic arteriosclerosis 13.57 10.93 8 296254 7861 70624321
Malassezia infection 13.56 10.93 5 296257 25 70632157
Arthritis infective 13.55 10.93 7 296255 7405 70624777
Ureteric compression 13.53 10.93 10 296252 243 70631939
Platelet disorder 13.52 10.93 32 296230 2559 70629623
Blood chloride decreased 13.51 10.93 8 296254 7842 70624340
Urinary tract infection bacterial 13.50 10.93 52 296210 5439 70626743
Cardiac valve disease 13.50 10.93 3 296259 5395 70626787
Epstein-Barr virus antigen positive 13.49 10.93 7 296255 88 70632094
Kidney transplant rejection 13.49 10.93 13 296249 9948 70622234
Live birth 13.46 10.93 23 296239 13756 70618426
Cutaneous T-cell lymphoma refractory 13.45 10.93 3 296259 0 70632182
Breast angiosarcoma 13.45 10.93 3 296259 0 70632182
Malignant cranial nerve neoplasm 13.45 10.93 3 296259 0 70632182
Interferon gamma level increased 13.45 10.93 3 296259 0 70632182
Cytokine abnormal 13.45 10.93 3 296259 0 70632182
Hepatosplenic abscess 13.45 10.93 3 296259 0 70632182
Urinary bladder atrophy 13.45 10.93 3 296259 0 70632182
Cytomegalovirus hepatitis 13.43 10.93 16 296246 722 70631460
Gout 13.43 10.93 50 296212 22956 70609226
Arachnoid cyst 13.40 10.93 11 296251 313 70631869
Pulmonary hypoplasia 13.40 10.93 6 296256 53 70632129
Metastases to stomach 13.36 10.93 10 296252 248 70631934
Extrasystoles 13.32 10.93 6 296256 6868 70625314
Anal infection 13.30 10.93 8 296254 136 70632046
Right ventricular failure 13.27 10.93 48 296214 22226 70609956
Transplant rejection 13.27 10.93 125 296137 18046 70614136
Anogenital warts 13.26 10.93 17 296245 828 70631354
Respiratory acidosis 13.25 10.93 14 296248 10267 70621915
Oral candidiasis 13.24 10.93 161 296101 24791 70607391
Monocyte count decreased 13.19 10.93 35 296227 3004 70629178
Hormone receptor positive breast cancer 13.14 10.93 11 296251 322 70631860
Carbohydrate antigen 15-3 increased 13.13 10.93 19 296243 1039 70631143
Tissue infiltration 13.09 10.93 15 296247 649 70631533
Blood HIV RNA increased 13.09 10.93 24 296238 1602 70630580
Dermatomyositis 13.09 10.93 38 296224 3437 70628745
Vaccination failure 13.08 10.93 22 296240 1371 70630811
Neutrophil percentage decreased 13.07 10.93 16 296246 743 70631439
Vaginal infection 13.06 10.93 3 296259 5275 70626907
Gastroenteritis cryptosporidial 13.05 10.93 10 296252 257 70631925
Systemic inflammatory response syndrome 13.03 10.93 83 296179 10629 70621553
Roseolovirus test positive 13.03 10.93 9 296253 196 70631986
Meningitis bacterial 13.03 10.93 31 296231 2487 70629695
Corynebacterium sepsis 13.02 10.93 6 296256 57 70632125
Refractoriness to platelet transfusion 13.00 10.93 8 296254 142 70632040
Mycobacterial infection 13 10.93 38 296224 3450 70628732
Dermatitis allergic 13.00 10.93 31 296231 16400 70615782
Desmoid tumour 12.99 10.93 9 296253 197 70631985
Pleocytosis 12.97 10.93 21 296241 1268 70630914
Intracranial pressure increased 12.96 10.93 63 296199 7293 70624889
Microgenia 12.96 10.93 4 296258 10 70632172
Stomatitis necrotising 12.95 10.93 9 296253 198 70631984
Brachydactyly 12.95 10.93 5 296257 29 70632153
TP53 gene mutation 12.95 10.93 5 296257 29 70632153
Food allergy 12.91 10.93 10 296252 8514 70623668
Affect lability 12.87 10.93 14 296248 10132 70622050
Tongue oedema 12.87 10.93 5 296257 6254 70625928
Monoparesis 12.87 10.93 36 296226 3188 70628994
Squamous cell carcinoma of the oral cavity 12.82 10.93 13 296249 489 70631693
Abdominal abscess 12.81 10.93 58 296204 6520 70625662
Disseminated tuberculosis 12.81 10.93 42 296220 4058 70628124
Alanine aminotransferase abnormal 12.79 10.93 9 296253 8050 70624132
Cold sweat 12.76 10.93 33 296229 16983 70615199
Pathological fracture 12.76 10.93 76 296186 9507 70622675
Endocardial fibrosis 12.76 10.93 6 296256 60 70632122
Duodenal ulcer 12.76 10.93 28 296234 15252 70616930
Fasciitis 12.76 10.93 16 296246 762 70631420
Colorectal cancer 12.74 10.93 10 296252 8460 70623722
Staphylococcus test positive 12.74 10.93 54 296208 5900 70626282
Cerebellar stroke 12.73 10.93 13 296249 493 70631689
Chronic lymphocytic leukaemia stage 2 12.69 10.93 4 296258 11 70632171
Breast cancer stage III 12.68 10.93 6 296256 6675 70625507
Median nerve injury 12.67 10.93 5 296257 31 70632151
Meningitis 12.53 10.93 71 296191 8722 70623460
Hypothermia 12.53 10.93 44 296218 20550 70611632
Central nervous system necrosis 12.50 10.93 10 296252 274 70631908
Arteriosclerosis coronary artery 12.50 10.93 31 296231 16184 70615998
Light chain analysis abnormal 12.48 10.93 8 296254 153 70632029
Precursor B-lymphoblastic lymphoma 12.43 10.93 4 296258 12 70632170
Splenic infection fungal 12.41 10.93 7 296255 105 70632077
HER2 positive breast cancer 12.37 10.93 11 296251 350 70631832
Pulmonary sarcoidosis 12.36 10.93 20 296242 1207 70630975
Micrococcus infection 12.35 10.93 7 296255 106 70632076
Infective thrombosis 12.34 10.93 6 296256 65 70632117
Glomerulonephritis membranous 12.33 10.93 23 296239 1556 70630626
Psychomotor retardation 12.32 10.93 4 296258 5594 70626588
Cystoid macular oedema 12.31 10.93 26 296236 1926 70630256
Varicella 12.30 10.93 32 296230 2715 70629467
Perineal ulceration 12.26 10.93 6 296256 66 70632116
JC virus CSF test positive 12.26 10.93 8 296254 158 70632024
Mantle cell lymphoma refractory 12.24 10.93 7 296255 108 70632074
Central nervous system neoplasm 12.24 10.93 7 296255 108 70632074
Infusion site vesicles 12.22 10.93 12 296250 434 70631748
Gingival hypertrophy 12.20 10.93 33 296229 2865 70629317
Opsoclonus myoclonus 12.20 10.93 9 296253 218 70631964
Herpes sepsis 12.20 10.93 4 296258 13 70632169
Areflexia 12.18 10.93 48 296214 5074 70627108
Suspected product quality issue 12.17 10.93 10 296252 285 70631897
Non-Hodgkin's lymphoma unspecified histology aggressive 12.16 10.93 5 296257 35 70632147
Clonal haematopoiesis 12.16 10.93 5 296257 35 70632147
Complication associated with device 12.15 10.93 30 296232 15683 70616499
Pleural disorder 12.14 10.93 16 296246 801 70631381
Metastatic lymphoma 12.13 10.93 9 296253 220 70631962
Mass 12.08 10.93 111 296151 15915 70616267
Pulmonary fibrosis 12.07 10.93 206 296056 34104 70598078
Retroperitoneal lymphadenopathy 12.07 10.93 18 296244 1012 70631170
Dysgraphia 12.06 10.93 38 296224 3594 70628588
Disseminated strongyloidiasis 12.04 10.93 8 296254 163 70632019
Tidal volume decreased 12.03 10.93 6 296256 69 70632113
Wall motion score index abnormal 12.01 10.93 7 296255 112 70632070
Pollakiuria 12.01 10.93 86 296176 33375 70598807
Fungal skin infection 12.00 10.93 50 296212 5422 70626760
Enterobacter sepsis 11.99 10.93 19 296243 1126 70631056
Chylothorax 11.98 10.93 14 296248 619 70631563
Skin cancer 11.98 10.93 24 296238 13512 70618670
Intestinal obstruction 11.97 10.93 104 296158 38721 70593461
Aspergilloma 11.97 10.93 13 296249 530 70631652
Blood test abnormal 11.96 10.93 27 296235 14563 70617619
Nasal septum disorder 11.96 10.93 7 296255 113 70632069
Pharyngeal swelling 11.94 10.93 6 296256 6447 70625735
Essential hypertension 11.93 10.93 4 296258 5480 70626702
Food protein-induced enterocolitis syndrome 11.93 10.93 5 296257 37 70632145
Myasthenia gravis 11.91 10.93 8 296254 7331 70624851
Lung neoplasm 11.90 10.93 56 296206 6398 70625784
Skin haemorrhage 11.89 10.93 15 296247 10165 70622017
Arthropod bite 11.84 10.93 8 296254 7307 70624875
Renal salt-wasting syndrome 11.80 10.93 14 296248 629 70631553
Diabetes mellitus 11.78 10.93 220 296042 71604 70560578
Listeria encephalitis 11.77 10.93 10 296252 299 70631883
Metastases to tonsils 11.76 10.93 4 296258 15 70632167
Mucosal haemorrhage 11.76 10.93 29 296233 2380 70629802
Peripheral coldness 11.75 10.93 27 296235 14473 70617709
Ureteric dilatation 11.75 10.93 8 296254 170 70632012
Lumbar spinal stenosis 11.72 10.93 3 296259 4900 70627282
Allogenic bone marrow transplantation therapy 11.70 10.93 5 296257 39 70632143
Hypoglossal nerve paresis 11.69 10.93 7 296255 118 70632064
Merycism 11.69 10.93 9 296253 233 70631949
Thrombotic thrombocytopenic purpura 11.69 10.93 54 296208 6123 70626059
Intraductal proliferative breast lesion 11.63 10.93 28 296234 2263 70629919
Cerebellar syndrome 11.63 10.93 48 296214 5183 70626999
Cheilitis 11.63 10.93 3 296259 4874 70627308
Noctiphobia 11.56 10.93 4 296258 16 70632166
Beta 2 microglobulin decreased 11.56 10.93 4 296258 16 70632166
Infusion site eschar 11.56 10.93 4 296258 16 70632166
Tooth infection 11.54 10.93 33 296229 16430 70615752
Haemoglobin abnormal 11.52 10.93 55 296207 6322 70625860
Haemorrhage intracranial 11.51 10.93 156 296106 24621 70607561
Torsade de pointes 11.50 10.93 38 296224 18078 70614104
Klebsiella test positive 11.49 10.93 21 296241 1398 70630784
Acral lentiginous melanoma 11.49 10.93 5 296257 41 70632141
Telangiectasia 11.48 10.93 19 296243 1168 70631014
Left ventricular failure 11.48 10.93 69 296193 8659 70623523
Peritonitis 11.47 10.93 163 296099 25996 70606186
Toothache 11.46 10.93 39 296223 18391 70613791
Breast cancer stage II 11.45 10.93 4 296258 5342 70626840
Gastrointestinal candidiasis 11.45 10.93 11 296251 387 70631795
Escherichia urinary tract infection 11.44 10.93 91 296171 12516 70619666
Hypothyroidism 11.42 10.93 129 296133 45626 70586556
Empyema 11.41 10.93 39 296223 3848 70628334
Genital haemorrhage 11.39 10.93 5 296257 5810 70626372
Radiotherapy to brain 11.38 10.93 5 296257 42 70632140
Breast prosthesis removal 11.38 10.93 3 296259 3 70632179
Bladder telangiectasia 11.38 10.93 3 296259 3 70632179
Non-obstructive cardiomyopathy 11.38 10.93 3 296259 3 70632179
Lineage switch leukaemia 11.38 10.93 3 296259 3 70632179
Subretinal hyperreflective exudation 11.38 10.93 3 296259 3 70632179
Toxic erythema of chemotherapy 11.37 10.93 9 296253 243 70631939
Tympanic membrane disorder 11.36 10.93 8 296254 180 70632002
Anaesthesia 11.35 10.93 12 296250 474 70631708
Haptoglobin decreased 11.32 10.93 20 296242 1297 70630885
Tendon pain 11.32 10.93 4 296258 5302 70626880
Lymphadenitis viral 11.28 10.93 5 296257 43 70632139
Pyomyositis 11.28 10.93 13 296249 566 70631616
Varicella virus test positive 11.28 10.93 8 296254 182 70632000
Clostridium test positive 11.25 10.93 45 296217 4791 70627391
Hypermetabolism 11.22 10.93 10 296252 319 70631863
Heart rate abnormal 11.19 10.93 50 296212 5589 70626593
Wrong product administered 11.19 10.93 11 296251 8340 70623842
Leukostasis syndrome 11.19 10.93 6 296256 81 70632101
Injection site extravasation 11.17 10.93 12 296250 8734 70623448
Cardiac failure acute 11.17 10.93 117 296145 17370 70614812
Bronchospasm 11.16 10.93 53 296209 22739 70609443
Glomerulonephritis membranoproliferative 11.16 10.93 13 296249 573 70631609
Penicillium infection 11.15 10.93 9 296253 250 70631932
Clostridial infection 11.15 10.93 48 296214 5281 70626901
Magnetic resonance imaging head abnormal 11.12 10.93 29 296233 2463 70629719
Periorbital infection 11.12 10.93 6 296256 82 70632100
Infusion site swelling 11.12 10.93 6 296256 6192 70625990
Uterine enlargement 11.11 10.93 16 296246 871 70631311
Mental impairment 11.09 10.93 36 296226 17219 70614963
Adenocarcinoma 11.03 10.93 37 296225 3616 70628566
COVID-19 11.03 10.93 544 295718 105213 70526969
Primary adrenal insufficiency 11.02 10.93 8 296254 189 70631993
Meniscus injury 11.02 10.93 6 296256 6161 70626021
Ageusia 11.01 10.93 29 296233 14833 70617349
Bladder hypertrophy 11.00 10.93 13 296249 582 70631600
Cerebral venous thrombosis 10.95 10.93 29 296233 2486 70629696
Pulmonary tuberculosis 10.95 10.93 63 296199 7782 70624400
Micturition urgency 10.95 10.93 19 296243 11295 70620887

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01AA01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ALKYLATING AGENTS
Nitrogen mustard analogues
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:50903 carcinogen
MeSH PA D000477 Alkylating Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018906 Antineoplastic Agents, Alkylating
MeSH PA D018501 Antirheumatic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009153 Mutagens
MeSH PA D019653 Myeloablative Agonists
MeSH PA D009676 Noxae

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Systemic AL amyloidosis indication 23132008
Multiple myeloma indication 109989006 DOID:9538
Malignant lymphoma indication 118600007 DOID:0060058
Mycosis fungoides indication 118618005
Carcinoma of breast indication 254838004 DOID:3459
Retinoblastoma indication 370967009 DOID:768
Neuroblastoma indication 432328008 DOID:769
Treatment prior to tumor-specific T-cell infusion therapy indication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.39 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Cytochrome P450 3A4 Enzyme IC50 5.68 WOMBAT-PK

External reference:

IDSource
4018114 VUID
N0000146452 NUI
D00287 KEGG_DRUG
6055-19-2 SECONDARY_CAS_RN
3002 RXNORM
4018114 VANDF
C0010583 UMLSCUI
CHEBI:4026 CHEBI
CHEMBL88 ChEMBL_ID
CHEMBL1200796 ChEMBL_ID
DB00531 DRUGBANK_ID
D003520 MESH_DESCRIPTOR_UI
2907 PUBCHEM_CID
7154 IUPHAR_LIGAND_ID
8N3DW7272P UNII
31952 MMSL
4519 MMSL
d00036 MMSL
002631 NDDF
387420009 SNOMEDCT_US
74470007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0054-0382 CAPSULE 25 mg ORAL NDA 27 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0054-0383 CAPSULE 50 mg ORAL NDA 27 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3233 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3244 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3255 INJECTION, POWDER, FOR SOLUTION 2 g ORAL ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-935 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-936 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-937 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-938 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-939 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-942 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-943 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-944 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-945 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-955 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-956 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-957 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-982 TABLET 25 mg ORAL NDA authorized generic 27 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-984 TABLET 50 mg ORAL NDA 27 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 16714-857 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 16714-858 INJECTION, POWDER, FOR SOLUTION 2 g ORAL ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 16714-859 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 54868-5005 TABLET 50 mg ORAL ANDA 19 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 54868-5218 TABLET 25 mg ORAL ANDA 19 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 54879-021 CAPSULE 25 mg ORAL ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 54879-021 CAPSULE 25 mg ORAL ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 54879-022 CAPSULE 50 mg ORAL ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 54879-022 CAPSULE 50 mg ORAL ANDA 25 sections
Cyclophosphamide Human Prescription Drug Label 1 55150-270 INJECTION 500 mg INTRAVENOUS NDA 26 sections
Cyclophosphamide Human Prescription Drug Label 1 55150-271 INJECTION 1 g INTRAVENOUS NDA 26 sections