cyclophosphamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
alkylating agents of the cyclophosphamide group 758 50-18-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cyclophosphamide
  • cyclophosphamid
  • cyclophosphamidum
  • cyclophosphan
  • cyclophosphane
  • cytophosphan
  • mitoxan
  • cyclophosphamide hydrate
  • endoxan
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
  • Molecular weight: 261.08
  • Formula: C7H15Cl2N2O2P
  • CLOGP: 0.80
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 41.57
  • ALOGS: -1.24
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 40 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 6.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 19.15 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 74 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.73 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.87 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 8 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 16, 1959 FDA BAXTER HLTHCARE
March 26, 2019 PMDA SHIONOGI & Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 6054.53 11.16 3892 168272 93775 50339185
Neutropenia 2988.85 11.16 3062 169102 144903 50288057
Bone marrow failure 1343.83 11.16 950 171214 26674 50406286
Acute myeloid leukaemia 1195.21 11.16 705 171459 14369 50418591
Myelosuppression 1153.26 11.16 663 171501 12854 50420106
Product use in unapproved indication 916.26 11.16 1510 170654 114309 50318651
Mucosal inflammation 897.71 11.16 880 171284 39262 50393698
Disease recurrence 885.88 11.16 651 171513 19430 50413530
Agranulocytosis 857.16 11.16 655 171509 20766 50412194
Leukopenia 846.84 11.16 1095 171069 66433 50366527
Myelodysplastic syndrome 838.38 11.16 564 171600 14568 50418392
Cytomegalovirus infection 827.95 11.16 598 171566 17364 50415596
Cytokine release syndrome 818.95 11.16 454 171710 8180 50424780
Pancytopenia 814.05 11.16 1203 170961 82827 50350133
Haematotoxicity 806.49 11.16 436 171728 7459 50425501
Second primary malignancy 782.97 11.16 409 171755 6505 50426455
Thrombocytopenia 731.64 11.16 1447 170717 126226 50306734
Disease progression 683.82 11.16 1194 170970 94672 50338288
Pyrexia 660.18 11.16 2797 169367 377406 50055554
Acute graft versus host disease 607.78 11.16 288 171876 3670 50429290
Pain 577.68 11.16 674 171490 578229 49854731
Pneumocystis jirovecii pneumonia 574.78 11.16 443 171721 14220 50418740
Neutrophil count decreased 571.51 11.16 743 171421 45283 50387677
Ejection fraction decreased 564.28 11.16 483 171681 18037 50414923
Cardiotoxicity 557.78 11.16 329 171835 6698 50426262
Malignant neoplasm progression 554.07 11.16 900 171264 67224 50365736
Cystitis haemorrhagic 533.85 11.16 258 171906 3444 50429516
White blood cell count decreased 517.19 11.16 1192 170972 115530 50317430
Diffuse large B-cell lymphoma recurrent 501.81 11.16 193 171971 1402 50431558
Fall 487.26 11.16 267 171897 334665 50098295
Febrile bone marrow aplasia 486.61 11.16 290 171874 6021 50426939
Sepsis 470.90 11.16 1246 170918 131679 50301281
Abdominal discomfort 462.81 11.16 110 172054 231531 50201429
Graft versus host disease 461.57 11.16 278 171886 5888 50427072
Joint swelling 460.52 11.16 132 172032 245154 50187806
Progressive multifocal leukoencephalopathy 455.29 11.16 349 171815 11108 50421852
Venoocclusive liver disease 448.26 11.16 240 171924 4021 50428939
Premature menopause 444.01 11.16 147 172017 643 50432317
Septic shock 430.80 11.16 730 171434 56445 50376515
Neutropenic sepsis 424.94 11.16 366 171798 13781 50419179
Metastases to bone 412.35 11.16 400 171764 17595 50415365
Chronic graft versus host disease 410.97 11.16 199 171965 2668 50430292
Product dose omission issue 409.68 11.16 67 172097 183771 50249189
Cardiomyopathy 407.98 11.16 373 171791 15213 50417747
Neurotoxicity 407.95 11.16 364 171800 14376 50418584
Rheumatoid arthritis 404.90 11.16 96 172068 202454 50230506
Completed suicide 393.80 11.16 12 172152 131877 50301083
Pemphigus 391.55 11.16 3 172161 120163 50312797
Posterior reversible encephalopathy syndrome 388.30 11.16 356 171808 14572 50418388
Arthralgia 388.07 11.16 558 171606 438144 49994816
Synovitis 382.19 11.16 8 172156 123857 50309103
Hypogammaglobulinaemia 380.84 11.16 239 171925 5460 50427500
Neoplasm progression 379.59 11.16 482 171682 28675 50404285
Contraindicated product administered 365.84 11.16 40 172124 148918 50284042
Cytopenia 359.01 11.16 272 171892 8503 50424457
Acute graft versus host disease in skin 351.61 11.16 182 171982 2836 50430124
Haemophagocytic lymphohistiocytosis 349.67 11.16 266 171898 8367 50424593
Multiple organ dysfunction syndrome 343.09 11.16 615 171549 49722 50383238
Swelling 340.21 11.16 129 172035 200743 50232217
Glossodynia 339.73 11.16 12 172152 115557 50317403
Off label use 327.28 11.16 2739 169425 471687 49961273
Nasopharyngitis 326.55 11.16 124 172040 192803 50240157
Pruritus 323.88 11.16 293 171871 283275 50149685
Weight increased 318.74 11.16 144 172020 201747 50231213
Arthropathy 315.17 11.16 75 172089 157831 50275129
Peripheral swelling 309.65 11.16 157 172007 205779 50227181
Systemic lupus erythematosus 307.14 11.16 54 172110 140568 50292392
Drug hypersensitivity 304.13 11.16 245 171919 250765 50182195
Therapy partial responder 300.35 11.16 218 171946 6373 50426587
Metastases to liver 299.90 11.16 356 171808 19748 50413212
Epstein-Barr virus infection 295.37 11.16 221 171943 6776 50426184
Hepatitis B 287.51 11.16 167 171997 3299 50429661
Palmar-plantar erythrodysaesthesia syndrome 283.61 11.16 346 171818 19752 50413208
Tumour lysis syndrome 281.64 11.16 220 171944 7201 50425759
Neuropathy peripheral 278.74 11.16 842 171322 95915 50337045
Therapeutic product effect decreased 278.71 11.16 61 172103 135989 50296971
Respiratory failure 277.41 11.16 809 171355 90372 50342588
Wound 273.99 11.16 23 172141 105771 50327189
Left ventricular dysfunction 272.16 11.16 250 171914 10256 50422704
Injection site pain 272.08 11.16 30 172134 110994 50321966
Headache 262.16 11.16 868 171296 505667 49927293
Acute lymphocytic leukaemia recurrent 255.99 11.16 128 172036 1847 50431113
Rash 253.11 11.16 712 171452 436759 49996201
Post transplant lymphoproliferative disorder 248.00 11.16 163 172001 4041 50428919
Graft versus host disease in skin 246.72 11.16 136 172028 2420 50430540
Cardiac failure 245.17 11.16 689 171475 75351 50357609
Aplasia 245.01 11.16 156 172008 3657 50429303
Acute promyelocytic leukaemia 242.97 11.16 97 172067 787 50432173
Maternal exposure before pregnancy 238.97 11.16 178 171986 5419 50427541
Platelet count decreased 238.80 11.16 820 171344 99906 50333054
Bronchopulmonary aspergillosis 237.33 11.16 201 171963 7391 50425569
Anxiety 236.23 11.16 157 172007 177449 50255511
Bone pain 233.18 11.16 504 171660 46725 50386235
Hepatitis B reactivation 232.09 11.16 122 172042 1965 50430995
Ovarian failure 231.36 11.16 100 172064 1011 50431949
Anaemia 230.14 11.16 1558 170606 250898 50182062
Dizziness 226.93 11.16 529 171635 345840 50087120
Pain in extremity 223.52 11.16 365 171799 272500 50160460
Pleural effusion 223.51 11.16 697 171467 80757 50352203
Metastases to lung 223 11.16 229 171935 10791 50422169
Staphylococcal bacteraemia 221.52 11.16 161 172003 4716 50428244
Musculoskeletal stiffness 211.64 11.16 86 172078 128395 50304565
Cytomegalovirus infection reactivation 208.30 11.16 123 172041 2508 50430452
Thrombotic microangiopathy 208.13 11.16 199 171965 8592 50424368
Venoocclusive disease 202.82 11.16 108 172056 1788 50431172
Sinusitis 202.04 11.16 170 171994 170388 50262572
Contusion 200.13 11.16 66 172098 112117 50320843
Metastases to lymph nodes 199.39 11.16 176 171988 6848 50426112
Interstitial lung disease 194.63 11.16 505 171659 52671 50380289
Fatigue 190.74 11.16 1520 170644 706081 49726879
Overdose 189.99 11.16 52 172112 99675 50333285
Neutropenic colitis 188.75 11.16 112 172052 2305 50430655
Cytomegalovirus viraemia 188.28 11.16 144 172020 4565 50428395
Congestive cardiomyopathy 182.64 11.16 151 172013 5367 50427593
Feeling abnormal 180.65 11.16 101 172063 125391 50307569
Diffuse large B-cell lymphoma 179.24 11.16 151 172013 5511 50427449
BK virus infection 178.01 11.16 115 172049 2766 50430194
Blood pressure increased 177.89 11.16 117 172047 133015 50299945
Immune effector cell-associated neurotoxicity syndrome 177.53 11.16 84 172080 1066 50431894
Hepatic enzyme increased 176.55 11.16 126 172038 137254 50295706
Breast cancer recurrent 175.89 11.16 127 172037 3681 50429279
Lymphopenia 175.08 11.16 240 171924 15381 50417579
Psoriasis 173.25 11.16 17 172147 68983 50363977
Diffuse large B-cell lymphoma refractory 172.59 11.16 80 172084 966 50431994
Discomfort 171.37 11.16 77 172087 108303 50324657
Human herpesvirus 6 infection 168.39 11.16 107 172057 2499 50430461
Injection site erythema 167.47 11.16 27 172137 74909 50358051
Adenovirus infection 165.70 11.16 114 172050 3054 50429906
Peripheral sensory neuropathy 165.21 11.16 154 172010 6437 50426523
Bacteraemia 165.16 11.16 224 171940 14209 50418751
Drug resistance 163.97 11.16 258 171906 18731 50414229
Metastases to central nervous system 163.67 11.16 197 171967 11085 50421875
Mucormycosis 160.57 11.16 102 172062 2381 50430579
Malaise 160.37 11.16 594 171570 334938 50098022
Cardiac dysfunction 160.05 11.16 89 172075 1612 50431348
Acute lymphocytic leukaemia 154.82 11.16 96 172068 2145 50430815
Graft versus host disease in gastrointestinal tract 154.80 11.16 104 172060 2677 50430283
Hypersensitivity 154.45 11.16 312 171852 214849 50218111
Hospitalisation 152.90 11.16 24 172140 67913 50365047
Aspergillus infection 151.32 11.16 149 172015 6672 50426288
Blood follicle stimulating hormone increased 150.92 11.16 44 172120 112 50432848
Psoriatic arthropathy 145.15 11.16 3 172161 47029 50385931
Irritable bowel syndrome 142.41 11.16 8 172156 51433 50381527
Insomnia 141.08 11.16 236 171928 174629 50258331
Blood cholesterol increased 140.22 11.16 13 172151 55202 50377758
Helicobacter infection 139.88 11.16 7 172157 49695 50383265
Urticaria 138.19 11.16 142 172022 129419 50303541
Neoplasm recurrence 137.66 11.16 91 172073 2278 50430682
Polyneuropathy 136.88 11.16 187 171977 11944 50421016
Drug intolerance 136.65 11.16 343 171821 218761 50214199
Somnolence 135.66 11.16 198 171966 154787 50278173
Arthritis 134.92 11.16 63 172101 86658 50346302
Abdominal pain upper 134.15 11.16 209 171955 159100 50273860
Condition aggravated 134.09 11.16 538 171626 296520 50136440
Osteoarthritis 134.02 11.16 34 172130 68572 50364388
Gait disturbance 133.90 11.16 189 171975 149816 50283144
Muscle spasms 131.22 11.16 140 172024 125413 50307547
Breast cancer metastatic 131.16 11.16 169 171995 10195 50422765
Infusion related reaction 131.16 11.16 235 171929 169322 50263638
Cytomegalovirus chorioretinitis 128.69 11.16 74 172090 1433 50431527
Fibromyalgia 127.65 11.16 6 172158 44972 50387988
B-cell lymphoma recurrent 127.61 11.16 49 172115 354 50432606
Depression 127.30 11.16 230 171934 165193 50267767
Duodenal ulcer perforation 126.55 11.16 7 172157 45604 50387356
Drug abuse 126.26 11.16 25 172139 59821 50373139
Therapy responder 124.58 11.16 46 172118 294 50432666
Stem cell transplant 124.30 11.16 75 172089 1593 50431367
Drug interaction 124.07 11.16 313 171851 199308 50233652
Loss of personal independence in daily activities 123.52 11.16 42 172122 70008 50362952
Inappropriate schedule of product administration 123.35 11.16 45 172119 71786 50361174
Mobility decreased 122.96 11.16 59 172105 79889 50353071
Acute graft versus host disease in intestine 122.92 11.16 74 172090 1565 50431395
Organising pneumonia 122.47 11.16 113 172051 4661 50428299
Drug ineffective 120.00 11.16 2016 170148 817317 49615643
Metastasis 118.97 11.16 107 172057 4268 50428692
Acute respiratory distress syndrome 117.94 11.16 237 171927 20862 50412098
Migraine 116.62 11.16 55 172109 75225 50357735
Epstein-Barr virus associated lymphoproliferative disorder 115.79 11.16 72 172092 1617 50431343
Computerised tomogram thorax abnormal 115.67 11.16 67 172097 1316 50431644
Viral haemorrhagic cystitis 114.33 11.16 53 172111 640 50432320
Lymphadenopathy 113.28 11.16 309 171855 33190 50399770
Enterococcal infection 112.64 11.16 128 172036 6770 50426190
Pulmonary haemorrhage 112.06 11.16 124 172040 6368 50426592
Injection site reaction 111.84 11.16 18 172146 50014 50382946
Injection site swelling 111.15 11.16 8 172156 41765 50391195
Intentional product misuse 111.04 11.16 14 172150 46720 50386240
Varicella zoster virus infection 110.40 11.16 81 172083 2408 50430552
Bronchitis 110.11 11.16 115 172049 104044 50328916
Injection site pruritus 109.69 11.16 7 172157 40404 50392556
Asthma 109.50 11.16 86 172078 89251 50343709
Pericarditis 109.41 11.16 66 172098 78623 50354337
Primary hypogonadism 109.18 11.16 35 172129 135 50432825
Central nervous system lymphoma 108.55 11.16 64 172100 1301 50431659
Injury 108.47 11.16 18 172146 48907 50384053
Confusional state 107.59 11.16 302 171862 185626 50247334
Suicide attempt 106.26 11.16 23 172141 51709 50381251
Systemic candida 104.32 11.16 82 172082 2708 50430252
Multiple sclerosis relapse 104.22 11.16 12 172152 42952 50390008
JC virus infection 103.73 11.16 69 172095 1746 50431214
Hypoxia 103.07 11.16 395 171769 50728 50382232
Leukaemia recurrent 102.89 11.16 60 172104 1194 50431766
Staphylococcal sepsis 102.29 11.16 123 172041 6913 50426047
Systemic mycosis 102.13 11.16 57 172107 1040 50431920
Colony stimulating factor therapy 101.90 11.16 39 172125 279 50432681
Klebsiella infection 101.71 11.16 124 172040 7070 50425890
Capillary leak syndrome 101.19 11.16 69 172095 1821 50431139
Injection site bruising 100.91 11.16 6 172158 36762 50396198
Blood glucose increased 98.91 11.16 60 172104 71264 50361696
Blood lactate dehydrogenase increased 97.93 11.16 210 171954 19352 50413608
Ovarian atrophy 97.25 11.16 28 172136 67 50432893
Stress 97.04 11.16 31 172133 53762 50379198
Lymphocyte count decreased 96.38 11.16 250 171914 26057 50406903
Impaired healing 96.37 11.16 59 172105 69727 50363233
Recurrent cancer 96.10 11.16 65 172099 1692 50431268
Transplant failure 95.50 11.16 60 172104 1373 50431587
Escherichia bacteraemia 94.33 11.16 81 172083 3035 50429925
Folliculitis 92.59 11.16 12 172152 39213 50393747
Refractory anaemia with an excess of blasts 92.39 11.16 39 172125 370 50432590
Leukoencephalopathy 92.10 11.16 88 172076 3795 50429165
Wheezing 92.08 11.16 48 172116 61999 50370961
Pneumonitis 91.72 11.16 264 171900 29246 50403714
White blood cell count abnormal 90.62 11.16 102 172062 5338 50427622
Anti-Muellerian hormone level decreased 90.40 11.16 27 172137 77 50432883
Pneumatosis intestinalis 90.04 11.16 67 172097 2036 50430924
Secondary immunodeficiency 90.03 11.16 54 172110 1134 50431826
Pulmonary alveolar haemorrhage 89.39 11.16 88 172076 3939 50429021
Incorrect dose administered 88.94 11.16 27 172137 48387 50384573
Chemotherapy 87.93 11.16 56 172108 1313 50431647
Bacterial sepsis 87.85 11.16 83 172081 3529 50429431
Respiratory syncytial virus infection 87.28 11.16 97 172067 5005 50427955
Acquired haemophilia 87.02 11.16 48 172116 855 50432105
Blister 86.19 11.16 98 172066 85320 50347640
Cytomegalovirus test positive 85.93 11.16 71 172093 2521 50430439
Pre-existing disease 85.11 11.16 29 172135 141 50432819
Product quality issue 84.79 11.16 5 172159 30853 50402107
Biopsy lung abnormal 84.29 11.16 28 172136 124 50432836
Fungaemia 83.69 11.16 63 172101 1949 50431011
Subclavian vein thrombosis 83.09 11.16 60 172104 1739 50431221
Hepatic failure 82.77 11.16 270 171894 32013 50400947
Balance disorder 82.72 11.16 71 172093 70519 50362441
Rhinovirus infection 81.76 11.16 79 172085 3455 50429505
Colitis 81.22 11.16 302 171862 38227 50394733
International normalised ratio increased 81.22 11.16 23 172141 43129 50389831
Gastrooesophageal reflux disease 81.19 11.16 84 172080 76344 50356616
Smooth muscle cell neoplasm 79.89 11.16 43 172121 728 50432232
B-cell type acute leukaemia 79.78 11.16 26 172138 107 50432853
Pseudocirrhosis 79.21 11.16 40 172124 590 50432370
Neutrophil count abnormal 78.70 11.16 66 172098 2393 50430567
Palpitations 78.54 11.16 125 172039 94381 50338579
Gastrointestinal toxicity 76.73 11.16 87 172077 4590 50428370
Myeloid leukaemia 76.51 11.16 32 172132 296 50432664
Blood luteinising hormone increased 76.45 11.16 24 172140 85 50432875
Disseminated intravascular coagulation 75.71 11.16 175 171989 16960 50416000
Weight decreased 75.68 11.16 442 171722 220803 50212157
Pneumonia fungal 75.40 11.16 83 172081 4237 50428723
Granulocytopenia 75.31 11.16 91 172073 5140 50427820
Cerebrovascular accident 75.17 11.16 129 172035 94551 50338409
Lennox-Gastaut syndrome 74.76 11.16 30 172134 247 50432713
Pneumonia cytomegaloviral 74.64 11.16 58 172106 1883 50431077
Acute graft versus host disease in liver 74.56 11.16 38 172126 572 50432388
Gene mutation 74.28 11.16 49 172115 1222 50431738
Urinary tract infection 73.23 11.16 454 171710 223566 50209394
Lung infiltration 73.13 11.16 149 172015 13244 50419716
Adverse drug reaction 73.07 11.16 49 172115 55173 50377787
Clostridium difficile colitis 72.75 11.16 176 171988 17566 50415394
Enterococcal bacteraemia 72.32 11.16 48 172116 1210 50431750
Ascites 72.21 11.16 277 171887 35584 50397376
Suicidal ideation 72.15 11.16 50 172114 55335 50377625
Pericardial effusion 71.99 11.16 221 171943 25368 50407592
Pneumocystis jirovecii infection 71.73 11.16 48 172116 1227 50431733
Venous thrombosis 71.45 11.16 82 172082 4384 50428576
Heart rate decreased 71.44 11.16 18 172146 36479 50396481
Herpes simplex 71.31 11.16 104 172060 7058 50425902
Leukaemia cutis 71.18 11.16 22 172142 73 50432887
Myelopathy 70.36 11.16 63 172101 2498 50430462
Amenorrhoea 70.11 11.16 113 172051 8371 50424589
Hepatotoxicity 70.06 11.16 228 171936 26998 50405962
Nasal congestion 69.49 11.16 44 172120 51076 50381884
Unevaluable event 69.30 11.16 35 172129 46031 50386929
Ill-defined disorder 69.02 11.16 51 172113 54603 50378357
Acute myelomonocytic leukaemia 68.62 11.16 25 172139 153 50432807
Blood pressure systolic increased 68.39 11.16 18 172146 35431 50397529
Bone marrow disorder 68.02 11.16 55 172109 1893 50431067
Chronic graft versus host disease in skin 67.68 11.16 37 172127 647 50432313
Embolism 67.67 11.16 100 172064 6868 50426092
Fusarium infection 66.47 11.16 34 172130 516 50432444
Alopecia areata 66.34 11.16 47 172117 1321 50431639
Hepatic function abnormal 66.26 11.16 253 171911 32428 50400532
Nephrolithiasis 66.21 11.16 18 172146 34675 50398285
Blood pressure fluctuation 65.76 11.16 20 172144 35803 50397157
Chronic obstructive pulmonary disease 64.76 11.16 52 172112 53383 50379577
Osteosarcoma 64.56 11.16 22 172142 107 50432853
Myocarditis 64.52 11.16 105 172059 7842 50425118
Memory impairment 64.03 11.16 107 172057 79253 50353707
Hypoglycaemia 63.87 11.16 53 172111 53528 50379432
Infection reactivation 62.47 11.16 40 172124 947 50432013
Aortitis 61.88 11.16 38 172126 834 50432126
Refractory cytopenia with multilineage dysplasia 61.60 11.16 22 172142 126 50432834
Acute leukaemia 61.58 11.16 41 172123 1039 50431921
Joint injury 61.52 11.16 3 172161 21786 50411174
Brain abscess 61.34 11.16 50 172114 1741 50431219
Metastases to pleura 61.33 11.16 44 172120 1262 50431698
Drug withdrawal syndrome 60.84 11.16 7 172157 25074 50407886
Hypertransaminasaemia 60.65 11.16 68 172096 3543 50429417
Alveolar soft part sarcoma 60.49 11.16 20 172144 87 50432873
Neck pain 60.29 11.16 63 172101 57004 50375956
Pseudomonal sepsis 60.21 11.16 53 172111 2054 50430906
Ventricular hypokinesia 60.20 11.16 71 172093 3909 50429051
Sedation 60.10 11.16 15 172149 30595 50402365
Serotonin syndrome 59.69 11.16 7 172157 24706 50408254
Staphylococcal infection 58.97 11.16 259 171905 35357 50397603
Therapy non-responder 58.91 11.16 335 171829 50687 50382273
Emotional distress 58.34 11.16 13 172151 28650 50404310
Osteonecrosis 58.32 11.16 189 171975 22328 50410632
Peripheral motor neuropathy 57.74 11.16 44 172120 1387 50431573
Hyperpyrexia 57.45 11.16 61 172103 2988 50429972
Myocardial infarction 57.27 11.16 137 172027 88890 50344070
Engraftment syndrome 56.38 11.16 26 172138 310 50432650
Adverse event 56.35 11.16 40 172124 43723 50389237
Skin toxicity 56.22 11.16 68 172096 3845 50429115
Idiopathic pneumonia syndrome 56.08 11.16 26 172138 314 50432646
Hip arthroplasty 55.83 11.16 17 172147 30412 50402548
Chronic myeloid leukaemia 55.24 11.16 51 172113 2105 50430855
Product use issue 55.23 11.16 291 171873 149184 50283776
Candida infection 55.21 11.16 191 171973 23332 50409628
Plasma cell myeloma recurrent 55.16 11.16 56 172108 2602 50430358
Upper respiratory fungal infection 55.01 11.16 21 172143 149 50432811
Type 2 diabetes mellitus 54.96 11.16 24 172140 34351 50398609
Flatulence 54.88 11.16 16 172148 29442 50403518
Hallucination 54.57 11.16 47 172117 46610 50386350
Premature delivery 54.56 11.16 191 171973 23472 50409488
Alveolar proteinosis 54.44 11.16 25 172139 295 50432665
Neutropenic infection 54.23 11.16 38 172126 1049 50431911
Cytomegalovirus colitis 54.12 11.16 48 172116 1879 50431081
Complications of bone marrow transplant 53.99 11.16 28 172136 438 50432522
Dry mouth 53.94 11.16 67 172097 56111 50376849
C-reactive protein abnormal 53.88 11.16 14 172150 27795 50405165
Alveolitis 53.71 11.16 54 172110 2480 50430480
Proteinuria 53.04 11.16 150 172014 16447 50416513
Blood stem cell transplant failure 52.87 11.16 20 172144 138 50432822
Femur fracture 52.66 11.16 31 172133 37433 50395527
Chronic myelomonocytic leukaemia 52.58 11.16 24 172140 279 50432681
Cataract 52.51 11.16 50 172114 47250 50385710
Multifocal micronodular pneumocyte hyperplasia 52.35 11.16 17 172147 69 50432891
Bronchial polyp 52.35 11.16 17 172147 69 50432891
Influenza 52.06 11.16 145 172019 89393 50343567
Toxic cardiomyopathy 52.05 11.16 19 172145 117 50432843
Surgery 51.71 11.16 19 172145 30186 50402774
Acne 51.42 11.16 4 172160 19591 50413369
Back pain 50.70 11.16 491 171673 219539 50213421
Pulmonary embolism 50.57 11.16 549 171615 101155 50331805
Musculoskeletal pain 50.56 11.16 106 172058 72071 50360889
Metastases to skin 50.32 11.16 40 172124 1343 50431617
Bone marrow transplant 50.27 11.16 30 172134 624 50432336
Disseminated mucormycosis 50.12 11.16 19 172145 132 50432828
Pneumomediastinum 49.96 11.16 37 172127 1116 50431844
Radiation skin injury 49.78 11.16 33 172131 830 50432130
Lactic acidosis 49.19 11.16 26 172138 33329 50399631
Jugular vein thrombosis 49.15 11.16 53 172111 2643 50430317
Fluid retention 49.05 11.16 60 172104 50589 50382371
Anti-neutrophil cytoplasmic antibody positive vasculitis 48.33 11.16 49 172115 2273 50430687
Nephropathy toxic 48.27 11.16 93 172071 7936 50425024
Gastric disorder 48.25 11.16 20 172144 29528 50403432
Nervousness 48.01 11.16 17 172147 27634 50405326
Invasive ductal breast carcinoma 47.75 11.16 78 172086 5843 50427117
Foot deformity 47.51 11.16 5 172159 19205 50413755
Pseudomonas infection 46.93 11.16 101 172063 9329 50423631
5q minus syndrome 46.81 11.16 20 172144 196 50432764
Klebsiella bacteraemia 46.60 11.16 37 172127 1240 50431720
Amnesia 46.53 11.16 45 172119 42215 50390745
Microangiopathic haemolytic anaemia 46.31 11.16 26 172138 480 50432480
Dyspepsia 46.10 11.16 116 172048 73981 50358979
Chronic lymphocytic leukaemia recurrent 45.98 11.16 19 172145 170 50432790
Acute myeloid leukaemia recurrent 45.92 11.16 38 172126 1352 50431608
Dry eye 45.90 11.16 26 172138 32069 50400891
Obliterative bronchiolitis 45.87 11.16 43 172121 1810 50431150
Road traffic accident 45.79 11.16 13 172151 24339 50408621
Joint stiffness 45.62 11.16 23 172141 30285 50402675
Mitral valve incompetence 45.57 11.16 147 172017 17324 50415636
Myeloproliferative neoplasm 45.54 11.16 25 172139 441 50432519
Medication error 45.18 11.16 34 172130 36070 50396890
Intestinal perforation 45.17 11.16 106 172058 10373 50422587
Nocardiosis 45.13 11.16 41 172123 1657 50431303
Cervix disorder 44.94 11.16 25 172139 453 50432507
Left ventricular dilatation 44.71 11.16 24 172140 404 50432556
Acute pulmonary oedema 44.70 11.16 85 172079 7182 50425778
Oedema peripheral 44.67 11.16 334 171830 157627 50275333
Sleep disorder 44.59 11.16 79 172085 57204 50375756
Illness 44.50 11.16 14 172150 24526 50408434
Osteolysis 44.41 11.16 49 172115 2508 50430452
Leukaemia 44.18 11.16 57 172107 3442 50429518
Lupus nephritis 44.17 11.16 47 172117 2308 50430652
Splenomegaly 44.16 11.16 100 172064 9560 50423400
Rash pruritic 43.93 11.16 59 172105 47787 50385173
Alpha haemolytic streptococcal infection 43.92 11.16 31 172133 866 50432094
Device related thrombosis 43.74 11.16 36 172128 1271 50431689
Treatment noncompliance 43.73 11.16 24 172140 30126 50402834
Parainfluenzae virus infection 43.54 11.16 42 172122 1833 50431127
Device dislocation 43.39 11.16 10 172154 21536 50411424
Enterobacter infection 43.29 11.16 42 172122 1846 50431114
Loss of consciousness 43.26 11.16 195 171969 104158 50328802
Viraemia 43.25 11.16 33 172131 1042 50431918
Pneumonia 43.08 11.16 1633 170531 376768 50056192
B-cell lymphoma refractory 43.04 11.16 15 172149 79 50432881
Lymphoma transformation 42.79 11.16 17 172147 136 50432824
Hyperhidrosis 42.78 11.16 158 172006 89268 50343692
Madarosis 42.64 11.16 48 172116 2512 50430448
Coronary artery disease 42.63 11.16 24 172140 29702 50403258
Periarticular thenar erythema with onycholysis 42.57 11.16 11 172153 14 50432946
Refractory cytopenia with unilineage dysplasia 42.54 11.16 25 172139 505 50432455
Lower respiratory tract infection 42.46 11.16 173 171991 95028 50337932
Mantle cell lymphoma recurrent 42.34 11.16 16 172148 110 50432850
Agitation 42.12 11.16 73 172091 53311 50379649
Gastrointestinal necrosis 42.06 11.16 48 172116 2550 50430410
Product prescribing error 41.68 11.16 10 172154 20951 50412009
Cardiomyopathy acute 41.55 11.16 18 172146 183 50432777
Encephalitis viral 41.35 11.16 38 172126 1559 50431401
Acute hepatitis B 41.33 11.16 21 172143 314 50432646
Swollen tongue 41.22 11.16 23 172141 28607 50404353
Extravasation 41.22 11.16 42 172122 1960 50431000
Tremor 41.16 11.16 226 171938 114677 50318283
Lymphadenitis 41.14 11.16 48 172116 2612 50430348
Foot fracture 41.12 11.16 9 172155 20082 50412878
Vision blurred 40.95 11.16 134 172030 78513 50354447
Human polyomavirus infection 40.91 11.16 20 172144 274 50432686
Stomatitis 40.63 11.16 525 171639 100819 50332141
Hypoalbuminaemia 40.62 11.16 98 172066 9762 50423198
Multiple sclerosis 40.31 11.16 10 172154 20483 50412477
Lumbosacral radiculoplexus neuropathy 40.23 11.16 11 172153 20 50432940
Aggression 40.21 11.16 11 172153 21105 50411855
Drug ineffective for unapproved indication 40.09 11.16 161 172003 21120 50411840
Crying 40.09 11.16 10 172154 20406 50412554
Maternal exposure during pregnancy 40.05 11.16 349 171815 159429 50273531
Heart rate increased 39.96 11.16 132 172032 77118 50355842
Burning sensation 39.77 11.16 58 172106 45388 50387572
Cryptococcosis 39.61 11.16 29 172135 859 50432101
Bursitis 39.48 11.16 13 172151 22122 50410838
Accidental overdose 39.47 11.16 9 172155 19524 50413436
Skin laceration 39.46 11.16 8 172156 18834 50414126
Portal hypertension 39.34 11.16 53 172111 3339 50429621
Pulmonary toxicity 39.20 11.16 69 172095 5493 50427467
Atelectasis 39.16 11.16 144 172020 18126 50414834
Clostridium bacteraemia 39.14 11.16 17 172147 174 50432786
Sciatica 39.13 11.16 12 172152 21370 50411590
Human bocavirus infection 39.04 11.16 21 172143 355 50432605
Acquired gene mutation 39.03 11.16 28 172136 803 50432157
Cutaneous calcification 38.66 11.16 14 172150 84 50432876
Ear infection 38.65 11.16 20 172144 25950 50407010
Hypoaesthesia 38.44 11.16 264 171900 126993 50305967
Plasma cell leukaemia 38.31 11.16 30 172134 985 50431975
Hypertension 38.10 11.16 498 171666 210705 50222255
Restlessness 38.05 11.16 19 172145 25154 50407806
Disease susceptibility 37.99 11.16 17 172147 188 50432772
Herpes zoster meningoencephalitis 37.94 11.16 19 172145 275 50432685
Adenoviral hepatitis 37.93 11.16 18 172146 230 50432730
Irritability 37.90 11.16 25 172139 28401 50404559
Encephalitis 37.83 11.16 80 172084 7300 50425660
Infection 37.76 11.16 811 171353 172143 50260817
Limb injury 37.72 11.16 11 172153 20239 50412721
Eye swelling 37.42 11.16 11 172153 20133 50412827
Metastases to the mediastinum 37.28 11.16 22 172142 448 50432512
Cardiac failure acute 37.26 11.16 85 172079 8165 50424795
Therapeutic response unexpected 37.24 11.16 5 172159 15910 50417050
Dyspnoea 37.22 11.16 1505 170659 546103 49886857
Angioedema 37.15 11.16 44 172120 37632 50395328
Hip fracture 37.09 11.16 21 172143 25910 50407050
Quadriplegia 37.04 11.16 37 172127 1686 50431274
Encephalitis cytomegalovirus 36.89 11.16 23 172141 519 50432441
Autoimmune haemolytic anaemia 36.85 11.16 56 172108 3943 50429017
Hyperkalaemia 36.82 11.16 67 172097 48022 50384938
Haematochezia 36.80 11.16 49 172115 39833 50393127
Device related infection 36.80 11.16 154 172010 20581 50412379
Encephalopathy 36.74 11.16 218 171946 33493 50399467
Oxygen saturation decreased 36.64 11.16 127 172037 73121 50359839
Lupus vasculitis 36.55 11.16 22 172142 465 50432495
Cytogenetic abnormality 36.47 11.16 22 172142 467 50432493
Humoral immune defect 36.47 11.16 13 172151 74 50432886
Dysplasia 36.46 11.16 25 172139 666 50432294
Lung consolidation 36.35 11.16 54 172110 3726 50429234
Intervertebral disc protrusion 36.33 11.16 12 172152 20381 50412579
Ileus paralytic 36.31 11.16 56 172108 3994 50428966
Klebsiella sepsis 36.09 11.16 31 172133 1162 50431798
Frequent bowel movements 36.08 11.16 3 172161 13915 50419045
Human herpesvirus 8 infection 36.05 11.16 17 172147 214 50432746
Nephrotic syndrome 36.01 11.16 61 172103 4709 50428251
Alternaria infection 35.91 11.16 17 172147 216 50432744
Limb discomfort 35.89 11.16 19 172145 24338 50408622
Abortion spontaneous 35.88 11.16 54 172110 41718 50391242
Blast cells present 35.88 11.16 20 172144 364 50432596
Vasculitis 35.84 11.16 117 172047 13874 50419086
Injection site rash 35.75 11.16 6 172158 16171 50416789
Pneumothorax 35.63 11.16 117 172047 13917 50419043
Aplastic anaemia 35.50 11.16 80 172084 7623 50425337
Nightmare 35.47 11.16 6 172158 16080 50416880
Depressed mood 35.44 11.16 38 172126 33985 50398975
Osteomyelitis bacterial 35.44 11.16 16 172148 181 50432779
Plasmacytoma 35.17 11.16 42 172122 2343 50430617
Meningitis cryptococcal 35.14 11.16 30 172134 1115 50431845
Panic attack 35.14 11.16 11 172153 19331 50413629
Musculoskeletal disorder 35.04 11.16 8 172156 17341 50415619
Engraft failure 34.82 11.16 19 172145 331 50432629
Bradycardia 34.78 11.16 108 172056 64318 50368642
Osteonecrosis of jaw 34.59 11.16 209 171955 32317 50400643
Sinus disorder 34.43 11.16 10 172154 18448 50414512
Disseminated toxoplasmosis 34.21 11.16 13 172151 91 50432869
Hyperferritinaemia 34.20 11.16 14 172150 122 50432838
Perineal infection 34.10 11.16 14 172150 123 50432837
Gastrosplenic fistula 34.00 11.16 11 172153 44 50432916
Hepatomegaly 33.96 11.16 97 172067 10696 50422264
Clonal evolution 33.86 11.16 12 172152 67 50432893
Systemic scleroderma 33.75 11.16 26 172138 833 50432127
Blood culture positive 33.73 11.16 56 172108 4252 50428708
Graft versus host disease in liver 33.71 11.16 21 172143 473 50432487
B-lymphocyte count abnormal 33.62 11.16 11 172153 46 50432914
Toxoplasmosis 33.39 11.16 32 172132 1385 50431575
Hepatitis E 33.30 11.16 30 172134 1199 50431761
Localised infection 33.19 11.16 23 172141 25462 50407498
Tendonitis 33.15 11.16 8 172156 16697 50416263
Bacterial infection 32.96 11.16 126 172038 16155 50416805
Traumatic lung injury 32.94 11.16 32 172132 1409 50431551
Drug reaction with eosinophilia and systemic symptoms 32.79 11.16 29 172135 28395 50404565
Death 32.76 11.16 1386 170778 323993 50108967
Lip swelling 32.65 11.16 22 172142 24714 50408246
Candida sepsis 32.52 11.16 30 172134 1237 50431723
Disability 32.45 11.16 3 172161 12772 50420188
Primary cardiac lymphoma 32.36 11.16 9 172155 18 50432942
Adenovirus reactivation 32.30 11.16 13 172151 108 50432852
Invasive lobular breast carcinoma 32.29 11.16 23 172141 652 50432308
Hair colour changes 32.26 11.16 43 172121 2681 50430279
Ankle fracture 32.26 11.16 7 172157 15715 50417245
Thyroid disorder 32.14 11.16 3 172161 12674 50420286
Minimal residual disease 32.09 11.16 13 172151 110 50432850
Withdrawal syndrome 31.96 11.16 10 172154 17580 50415380
Kidney infection 31.74 11.16 12 172152 18734 50414226
Miller Fisher syndrome 31.70 11.16 12 172152 83 50432877
Graft versus host disease in lung 31.70 11.16 18 172146 340 50432620
Perineal necrosis 31.69 11.16 13 172151 114 50432846
Gait inability 31.68 11.16 48 172116 36979 50395981
Cerebral toxoplasmosis 31.57 11.16 23 172141 676 50432284
Paraparesis 31.51 11.16 37 172127 2027 50430933
Throat irritation 31.25 11.16 34 172130 30205 50402755
Seasonal allergy 31.22 11.16 6 172158 14670 50418290
Ocular hyperaemia 31.15 11.16 15 172149 20277 50412683
Guillain-Barre syndrome 31.06 11.16 48 172116 3429 50429531
Prescribed overdose 30.99 11.16 6 172158 14594 50418366
Escherichia sepsis 30.94 11.16 54 172110 4270 50428690
Chronic kidney disease 30.81 11.16 55 172109 39716 50393244
Streptococcal bacteraemia 30.77 11.16 31 172133 1427 50431533
Gastrointestinal fungal infection 30.75 11.16 16 172148 252 50432708
Respiratory arrest 30.72 11.16 34 172130 29975 50402985
Therapy cessation 30.66 11.16 26 172138 25985 50406975
Red blood cell sedimentation rate increased 30.48 11.16 33 172131 29383 50403577
Enterococcal sepsis 30.44 11.16 29 172135 1246 50431714
Macular degeneration 30.36 11.16 6 172158 14382 50418578
Unintentional medical device removal 30.31 11.16 61 172103 5374 50427586
Disseminated cryptococcosis 30.26 11.16 18 172146 372 50432588
Injection site mass 30.17 11.16 8 172156 15672 50417288
Babesiosis 30.15 11.16 15 172149 214 50432746
Triple negative breast cancer 29.99 11.16 12 172152 98 50432862
Lower limb fracture 29.94 11.16 6 172158 14240 50418720
Mood altered 29.92 11.16 4 172160 12769 50420191
Laryngitis fungal 29.85 11.16 13 172151 134 50432826
Combined immunodeficiency 29.57 11.16 12 172152 102 50432858
Gastroenteritis norovirus 29.52 11.16 33 172131 1714 50431246
Metastases to chest wall 29.33 11.16 19 172145 459 50432501
Therapy interrupted 29.29 11.16 16 172148 20136 50412824
Malignant transformation 29.12 11.16 17 172147 339 50432621
B precursor type acute leukaemia 29.03 11.16 13 172151 144 50432816
Cerebral venous sinus thrombosis 29.03 11.16 32 172132 1636 50431324
Oesophageal candidiasis 28.99 11.16 57 172107 4937 50428023
Pulmonary veno-occlusive disease 28.81 11.16 25 172139 950 50432010
Fear 28.81 11.16 7 172157 14542 50418418
Citrobacter bacteraemia 28.76 11.16 8 172156 16 50432944
Retinal haemorrhage 28.69 11.16 54 172110 4527 50428433
Visual impairment 28.64 11.16 127 172037 68148 50364812
Sopor 28.58 11.16 16 172148 19863 50413097
IIIrd nerve paralysis 28.57 11.16 21 172143 626 50432334
Tuberculosis of central nervous system 28.52 11.16 16 172148 295 50432665
Hydrothorax 28.45 11.16 22 172142 709 50432251
Product complaint 28.32 11.16 3 172161 11463 50421497
Nasal septum disorder 28.23 11.16 12 172152 116 50432844
Haemoglobin decreased 28.22 11.16 598 171566 126618 50306342
Hyperviscosity syndrome 28.19 11.16 13 172151 155 50432805
Symptom masked 27.94 11.16 21 172143 648 50432312
Adult T-cell lymphoma/leukaemia 27.93 11.16 14 172150 203 50432757
Spinal stenosis 27.87 11.16 6 172158 13544 50419416
Faeces discoloured 27.84 11.16 10 172154 16114 50416846
Primary mediastinal large B-cell lymphoma recurrent 27.61 11.16 10 172154 60 50432900
Pneumonia adenoviral 27.54 11.16 8 172156 20 50432940
Listeria sepsis 27.54 11.16 20 172144 585 50432375
Skin discolouration 27.51 11.16 43 172121 32714 50400246
Lung diffusion test decreased 27.42 11.16 20 172144 589 50432371
Prescribed underdose 27.35 11.16 10 172154 15939 50417021
Pneumonia bacterial 27.32 11.16 70 172094 7239 50425721
Cardiac cirrhosis 27.28 11.16 12 172152 127 50432833
Acute monocytic leukaemia 27.20 11.16 10 172154 63 50432897
Erythropoiesis abnormal 27.15 11.16 15 172149 268 50432692
Metastases to bone marrow 27.10 11.16 15 172149 269 50432691
BK polyomavirus test positive 27.07 11.16 9 172155 40 50432920
Rash macular 27.02 11.16 16 172148 19261 50413699
Respiratory distress 26.96 11.16 187 171977 30302 50402658
Necrotising gastritis 26.81 11.16 10 172154 66 50432894
B-cell aplasia 26.71 11.16 9 172155 42 50432918
T-cell lymphoma 26.70 11.16 20 172144 614 50432346
Large intestinal ulcer perforation 26.68 11.16 10 172154 67 50432893
Carpal tunnel syndrome 26.68 11.16 12 172152 16881 50416079
Hair texture abnormal 26.60 11.16 46 172118 3610 50429350
Metastases to peritoneum 26.57 11.16 40 172124 2793 50430167
Exostosis 26.47 11.16 4 172160 11649 50421311
Pneumonitis chemical 26.47 11.16 13 172151 180 50432780
Gallbladder disorder 26.28 11.16 12 172152 16730 50416230
Diabetic ketoacidosis 26.25 11.16 14 172150 17858 50415102
Haematuria 26.24 11.16 163 172001 25450 50407510
Paraneoplastic pemphigus 26.21 11.16 9 172155 45 50432915
Diffuse alveolar damage 26.18 11.16 22 172142 800 50432160
Subdural hygroma 26.17 11.16 14 172150 234 50432726
Hepatic lesion 26.05 11.16 48 172116 3960 50429000
Device issue 26.04 11.16 18 172146 19954 50413006
Cyst 25.89 11.16 5 172159 12182 50420778
Eye irritation 25.81 11.16 13 172151 17127 50415833
Polyomavirus-associated nephropathy 25.68 11.16 29 172135 1523 50431437
Carbohydrate antigen 15-3 increased 25.62 11.16 25 172139 1107 50431853
Myelitis 25.61 11.16 26 172138 1208 50431752
Sleep apnoea syndrome 25.60 11.16 26 172138 23842 50409118
Steroid diabetes 25.58 11.16 23 172141 917 50432043
Haematocrit decreased 25.52 11.16 205 171959 34771 50398189
Incorrect route of product administration 25.45 11.16 16 172148 18650 50414310
Orthostatic hypotension 25.43 11.16 38 172126 29443 50403517
Ligament sprain 25.37 11.16 3 172161 10522 50422438
Strongyloidiasis 25.33 11.16 22 172142 837 50432123
Blood pressure decreased 25.30 11.16 101 172063 55808 50377152
Pneumonia influenzal 25.28 11.16 28 172136 1439 50431521
Hair follicle tumour benign 25.28 11.16 16 172148 371 50432589
Hepatocellular injury 25.26 11.16 163 172001 25784 50407176
Leukocytosis 25.24 11.16 147 172017 22432 50410528
Labelled drug-drug interaction medication error 25.22 11.16 3 172161 10474 50422486
Systolic dysfunction 25.20 11.16 28 172136 1444 50431516
Leukaemic lymphoma 25.17 11.16 10 172154 80 50432880
Primary adrenal insufficiency 25.14 11.16 9 172155 52 50432908
Pharyngeal inflammation 25.09 11.16 19 172145 593 50432367
Premature labour 25.06 11.16 91 172073 11385 50421575
Glaucoma 25.00 11.16 11 172153 15675 50417285
Epstein Barr virus positive mucocutaneous ulcer 24.98 11.16 16 172148 379 50432581
Feeling jittery 24.97 11.16 4 172160 11156 50421804
Dyskinesia 24.93 11.16 35 172129 27826 50405134
Lymphocytosis 24.92 11.16 34 172130 2168 50430792
Procedural pain 24.89 11.16 8 172156 13824 50419136
Mesenteric abscess 24.85 11.16 10 172154 83 50432877
Transaminases increased 24.80 11.16 171 171993 27653 50405307
Abdominal compartment syndrome 24.74 11.16 18 172146 528 50432432
Respiratory tract infection fungal 24.72 11.16 16 172148 386 50432574
Lymphangiosis carcinomatosa 24.46 11.16 25 172139 1171 50431789
Administration site extravasation 24.42 11.16 20 172144 701 50432259
Toxicity to various agents 24.33 11.16 544 171620 211955 50221005
Lymphadenopathy mediastinal 24.33 11.16 36 172128 2475 50430485
Hormone receptor positive breast cancer 24.27 11.16 17 172147 469 50432491
Thyroid dermatopathy 24.24 11.16 7 172157 17 50432943
Lung disorder 24.21 11.16 246 171918 44553 50388407
Respiratory tract congestion 24.19 11.16 9 172155 14190 50418770
Blood iron decreased 24.18 11.16 5 172159 11610 50421350
Bone marrow transplant rejection 24.18 11.16 9 172155 59 50432901
Tumour necrosis 24.11 11.16 20 172144 714 50432246
Acute lymphocytic leukaemia refractory 24.05 11.16 9 172155 60 50432900
Restless legs syndrome 24.02 11.16 12 172152 15885 50417075
Hypersomnia 24.00 11.16 11 172153 15303 50417657
Haemoglobin abnormal 23.99 11.16 49 172115 4363 50428597
Natural killer-cell leukaemia 23.96 11.16 10 172154 92 50432868
Nail pigmentation 23.82 11.16 12 172152 176 50432784
Mucosal infection 23.79 11.16 11 172153 132 50432828
Gout 23.75 11.16 5 172159 11465 50421495
Head injury 23.74 11.16 28 172136 23992 50408968
Fungal infection 23.73 11.16 179 171985 29786 50403174
Grip strength decreased 23.68 11.16 6 172158 12115 50420845
Scedosporium infection 23.67 11.16 16 172148 416 50432544
Intracardiac thrombus 23.58 11.16 33 172131 2156 50430804
Urinary tract infection bacterial 23.58 11.16 47 172117 4112 50428848
Sinus congestion 23.56 11.16 9 172155 13962 50418998
Vocal cord paralysis 23.53 11.16 29 172135 1672 50431288
Nasal abscess 23.50 11.16 11 172153 136 50432824
Pulmonary fibrosis 23.47 11.16 153 172011 24284 50408676
Pelvic kidney 23.43 11.16 5 172159 0 50432960
Growth hormone deficiency 23.43 11.16 11 172153 137 50432823
Hypoproteinaemia 23.39 11.16 30 172134 1801 50431159
Trichosporon infection 23.30 11.16 13 172151 237 50432723
Ovarian disorder 23.27 11.16 19 172145 663 50432297
Mantle cell lymphoma 23.21 11.16 16 172148 430 50432530
Haemolytic anaemia 23.17 11.16 77 172087 9215 50423745
Abdominal distension 23.13 11.16 149 172015 72754 50360206
Gastroenteritis viral 23.11 11.16 18 172146 18768 50414192
Muscle spasticity 23.06 11.16 15 172149 17169 50415791
Epstein-Barr viraemia 22.98 11.16 21 172143 855 50432105
Superior vena cava syndrome 22.96 11.16 18 172146 592 50432368
Ear pain 22.93 11.16 38 172126 28245 50404715
Blood calcium decreased 22.85 11.16 22 172142 20684 50412276
Chest pain 22.84 11.16 444 171720 176438 50256522
Product administration error 22.84 11.16 20 172144 19679 50413281
Cystitis viral 22.80 11.16 10 172154 105 50432855
Retinal toxicity 22.80 11.16 24 172140 1164 50431796
Metastases to meninges 22.79 11.16 31 172133 1971 50430989
Abnormal behaviour 22.74 11.16 20 172144 19638 50413322
Heart rate abnormal 22.49 11.16 45 172119 3947 50429013
Cholelithiasis 22.43 11.16 61 172103 37912 50395048
Adenoviral haemorrhagic cystitis 22.42 11.16 11 172153 152 50432808
Feeling hot 22.39 11.16 64 172100 39138 50393822
Hydrocephalus 22.37 11.16 50 172114 4738 50428222
Cytology abnormal 22.27 11.16 6 172158 10 50432950
T-cell type acute leukaemia 22.23 11.16 8 172156 47 50432913
Mucocutaneous ulceration 22.23 11.16 11 172153 155 50432805
Antithrombin III 22.16 11.16 11 172153 156 50432804
Shock 22.15 11.16 133 172031 20517 50412443
Blood lactate dehydrogenase abnormal 22.10 11.16 12 172152 207 50432753
Cerebellar stroke 22.10 11.16 12 172152 207 50432753
Rhabdomyolysis 22.08 11.16 64 172100 38963 50393997
Ototoxicity 22.04 11.16 23 172141 1104 50431856
Chronic graft versus host disease in liver 22.02 11.16 13 172151 265 50432695
Plasma cell myeloma 22 11.16 182 171982 31140 50401820
Bone lesion 21.96 11.16 52 172112 5118 50427842
Radiation necrosis 21.95 11.16 14 172150 329 50432631
Salivary gland cancer 21.86 11.16 11 172153 161 50432799
Cardiogenic shock 21.82 11.16 108 172056 15491 50417469
Flushing 21.75 11.16 136 172028 66879 50366081
Metabolic acidosis 21.73 11.16 64 172100 38761 50394199
Blood glucose decreased 21.71 11.16 18 172146 18193 50414767
Chest discomfort 21.70 11.16 206 171958 92516 50340444
Haematocolpos 21.68 11.16 8 172156 51 50432909
Hilar lymphadenopathy 21.62 11.16 22 172142 1025 50431935
Cholangiocarcinoma 21.60 11.16 22 172142 1026 50431934
Fungal sepsis 21.59 11.16 23 172141 1131 50431829
Cholecystectomy 21.58 11.16 3 172161 9300 50423660
Postictal state 21.53 11.16 21 172143 929 50432031
Morganella infection 21.46 11.16 17 172147 568 50432392
Scleroderma renal crisis 21.42 11.16 13 172151 279 50432681
Acute biphenotypic leukaemia 21.42 11.16 8 172156 53 50432907
Hepatosplenic T-cell lymphoma 21.38 11.16 17 172147 571 50432389
Metastases to diaphragm 21.25 11.16 7 172157 30 50432930
Glioma 21.18 11.16 13 172151 285 50432675
Leukoerythroblastosis 21.16 11.16 12 172152 226 50432734
Necrotising colitis 21.14 11.16 16 172148 499 50432461
Febrile infection 21.10 11.16 23 172141 1161 50431799
Impaired work ability 21.06 11.16 10 172154 13630 50419330
B-cell lymphoma 21.00 11.16 37 172127 2948 50430012
Hyperbilirubinaemia 20.99 11.16 76 172088 9494 50423466
Muscle rigidity 20.95 11.16 4 172160 9825 50423135
Central nervous system infection 20.95 11.16 18 172146 675 50432285
Platelet count abnormal 20.93 11.16 36 172128 2813 50430147
Aplasia pure red cell 20.81 11.16 45 172119 4170 50428790
Blood pressure diastolic decreased 20.74 11.16 16 172148 16765 50416195
Delayed engraftment 20.73 11.16 9 172155 92 50432868
Joint dislocation 20.70 11.16 8 172156 12325 50420635
Conjunctival scar 20.66 11.16 6 172158 15 50432945
Malignant pleural effusion 20.58 11.16 32 172132 2298 50430662
Poor quality sleep 20.41 11.16 16 172148 16630 50416330
B-lymphocyte count decreased 20.41 11.16 20 172144 890 50432070
Product storage error 20.40 11.16 8 172156 12216 50420744
Myasthenia gravis crisis 20.38 11.16 14 172150 374 50432586
Transient ischaemic attack 20.36 11.16 50 172114 32160 50400800
Groin pain 20.32 11.16 3 172161 8888 50424072
Mucosal toxicity 20.26 11.16 13 172151 309 50432651
Pseudomembranous colitis 20.21 11.16 35 172129 2750 50430210
Geotrichum infection 20.18 11.16 15 172149 455 50432505
Clostridium difficile infection 20.17 11.16 152 172012 25287 50407673
Appendiceal abscess 20.14 11.16 11 172153 192 50432768
Herpes simplex viraemia 20.14 11.16 10 172154 142 50432818
Pelvic fracture 20.14 11.16 7 172157 11513 50421447
Medulloblastoma recurrent 20.13 11.16 8 172156 64 50432896
Tissue infiltration 20.13 11.16 16 172148 537 50432423
Mucoepidermoid carcinoma 20.07 11.16 7 172157 37 50432923
Angiocentric lymphoma 20.06 11.16 16 172148 540 50432420
Recall phenomenon 20.06 11.16 16 172148 540 50432420
Atypical haemolytic uraemic syndrome 20.03 11.16 16 172148 541 50432419
Syphilis 20.01 11.16 10 172154 144 50432816
Reversible cerebral vasoconstriction syndrome 19.99 11.16 30 172134 2089 50430871
Blood creatine phosphokinase increased 19.95 11.16 37 172127 26330 50406630
Lupus-like syndrome 19.94 11.16 4 172160 9487 50423473
Autoimmune neutropenia 19.92 11.16 8 172156 66 50432894
Mediastinum neoplasm 19.92 11.16 8 172156 66 50432894
Enteral nutrition 19.91 11.16 7 172157 38 50432922
Peripheral sensorimotor neuropathy 19.90 11.16 23 172141 1239 50431721
Bone marrow necrosis 19.82 11.16 8 172156 67 50432893
Blood potassium increased 19.81 11.16 16 172148 16382 50416578
Metastases to spine 19.80 11.16 35 172129 2796 50430164
Diabetes mellitus inadequate control 19.75 11.16 10 172154 13135 50419825
Eye pain 19.73 11.16 42 172122 28407 50404553
Thrombotic thrombocytopenic purpura 19.71 11.16 40 172124 3545 50429415
Eye infection 19.69 11.16 4 172160 9402 50423558
Cystoid macular oedema 19.59 11.16 24 172140 1375 50431585
Dystonia 19.59 11.16 8 172156 11918 50421042
Blood pressure diastolic abnormal 19.55 11.16 4 172160 9357 50423603
T-cell lymphoma recurrent 19.51 11.16 5 172159 6 50432954
Creatinine renal clearance decreased 19.46 11.16 8 172156 11873 50421087
Focal nodular hyperplasia 19.43 11.16 15 172149 482 50432478
Necrosis 19.43 11.16 47 172117 4689 50428271
Paranasal sinus mucosal hypertrophy 19.39 11.16 6 172158 20 50432940
Hepatosplenomegaly 19.38 11.16 31 172133 2281 50430679
Glycosylated haemoglobin increased 19.32 11.16 6 172158 10600 50422360
Arteritis 19.30 11.16 15 172149 487 50432473
Incorrect product administration duration 19.30 11.16 4 172160 9271 50423689
Metastases to breast 19.24 11.16 12 172152 271 50432689
Tooth disorder 19.23 11.16 33 172131 24195 50408765
Troponin I increased 19.22 11.16 28 172136 1898 50431062
Sneezing 19.20 11.16 12 172152 14032 50418928
Primary immunodeficiency syndrome 19.19 11.16 7 172157 43 50432917
Lymphoma 19.19 11.16 74 172090 9527 50423433
Rectal haemorrhage 19.18 11.16 67 172097 38491 50394469
Primary mediastinal large B-cell lymphoma 19.17 11.16 6 172158 21 50432939
Opportunistic infection 19.13 11.16 26 172138 1652 50431308
Metastases to thorax 19.13 11.16 11 172153 213 50432747
Rash erythematous 19.11 11.16 58 172106 34794 50398166
Vertigo 19.07 11.16 101 172063 51731 50381229
Swelling face 19.07 11.16 103 172061 52492 50380468
Pulmonary mucormycosis 19.04 11.16 11 172153 215 50432745
Skin mass 19.01 11.16 49 172115 5086 50427874
Brain oedema 19.01 11.16 88 172076 12282 50420678
Cranial nerve disorder 19.00 11.16 13 172151 345 50432615
Vascular compression 18.97 11.16 9 172155 115 50432845
Rhabdomyosarcoma recurrent 18.95 11.16 6 172158 22 50432938
Cytomegalovirus enteritis 18.95 11.16 11 172153 217 50432743
Respiratory tract infection 18.85 11.16 179 171985 31838 50401122
Carotid intima-media thickness increased 18.85 11.16 8 172156 77 50432883
Breast angiosarcoma 18.75 11.16 4 172160 0 50432960
Hyperuricaemia 18.73 11.16 46 172118 4634 50428326
Infusion site streaking 18.68 11.16 14 172150 430 50432530
Morphoea 18.63 11.16 12 172152 287 50432673
Opsoclonus myoclonus 18.63 11.16 9 172155 120 50432840
Underdose 18.62 11.16 25 172139 20253 50412707
Mycobacterial infection 18.61 11.16 25 172139 1571 50431389
Poor venous access 18.57 11.16 6 172158 10334 50422626
Rotator cuff syndrome 18.55 11.16 8 172156 11536 50421424
Pulmonary infarction 18.54 11.16 31 172133 2367 50430593
Enterocolitis infectious 18.54 11.16 24 172140 1454 50431506
Cholecystitis chronic 18.48 11.16 5 172159 9664 50423296
Tooth fracture 18.43 11.16 5 172159 9646 50423314
Listeriosis 18.40 11.16 23 172141 1345 50431615
Pleural neoplasm 18.38 11.16 11 172153 230 50432730
Enteritis 18.37 11.16 59 172105 6936 50426024
Hepatitis C RNA increased 18.37 11.16 9 172155 124 50432836
Wrong technique in product usage process 18.35 11.16 112 172052 55398 50377562
Dry skin 18.31 11.16 80 172084 43111 50389849
Granulicatella infection 18.30 11.16 7 172157 50 50432910
Vena cava thrombosis 18.20 11.16 28 172136 1993 50430967
Thinking abnormal 18.18 11.16 5 172159 9562 50423398
Cardiac amyloidosis 18.16 11.16 17 172147 714 50432246
Endocarditis 18.16 11.16 48 172116 5059 50427901
Pleural disorder 18.14 11.16 15 172149 533 50432427
Enterobacter bacteraemia 18.09 11.16 11 172153 237 50432723
Bone marrow infiltration 18.03 11.16 14 172150 454 50432506
Epstein-Barr virus associated lymphoma 18.00 11.16 14 172150 455 50432505
Primary amyloidosis 17.98 11.16 6 172158 27 50432933
Cancer in remission 17.98 11.16 6 172158 27 50432933
Anger 17.98 11.16 8 172156 11325 50421635
Sinus polyp 17.96 11.16 12 172152 306 50432654
Bronchiectasis 17.95 11.16 76 172088 10207 50422753
Metastases to stomach 17.89 11.16 10 172154 183 50432777
Joint range of motion decreased 17.85 11.16 22 172142 18490 50414470
Angioimmunoblastic T-cell lymphoma 17.84 11.16 8 172156 89 50432871
Dysphonia 17.76 11.16 70 172094 38822 50394138
Left ventricular failure 17.72 11.16 46 172118 4795 50428165
Herpes zoster cutaneous disseminated 17.69 11.16 9 172155 135 50432825
Mediastinitis 17.60 11.16 10 172154 189 50432771
Breast neoplasm 17.54 11.16 22 172142 1291 50431669
Chylothorax 17.53 11.16 11 172153 251 50432709
Germ cell cancer 17.51 11.16 7 172157 57 50432903
Basal ganglion degeneration 17.47 11.16 13 172151 395 50432565
Marrow hyperplasia 17.47 11.16 15 172149 562 50432398
Influenza like illness 17.43 11.16 119 172045 57340 50375620
Body temperature decreased 17.42 11.16 18 172146 16377 50416583
Middle insomnia 17.39 11.16 6 172158 9915 50423045
Bronchiolitis 17.38 11.16 30 172134 2351 50430609
Fusobacterium infection 17.31 11.16 6 172158 31 50432929
Rhinocerebral mucormycosis 17.24 11.16 10 172154 197 50432763
Jaw operation 17.23 11.16 17 172147 763 50432197
Cardio-respiratory arrest 17.16 11.16 110 172054 53782 50379178
Upper-airway cough syndrome 17.15 11.16 4 172160 8546 50424414
Nervous system disorder 17.09 11.16 104 172060 16119 50416841
Corynebacterium infection 17.08 11.16 13 172151 409 50432551
Burkitt's lymphoma 17.07 11.16 5 172159 13 50432947
Computerised tomogram thorax 17.06 11.16 9 172155 146 50432814
Deep vein thrombosis 17.04 11.16 347 171817 72957 50360003
Sweat gland tumour 17.01 11.16 8 172156 100 50432860
Chronic myeloid leukaemia recurrent 16.93 11.16 10 172154 204 50432756
Lymphoproliferative disorder 16.90 11.16 33 172131 2844 50430116
Single functional kidney 16.79 11.16 9 172155 151 50432809
Pneumonia pseudomonal 16.79 11.16 27 172137 1996 50430964
Myocardial fibrosis 16.78 11.16 16 172148 688 50432272
Hypermetabolism 16.74 11.16 9 172155 152 50432808
Sarcoidosis 16.68 11.16 46 172118 4971 50427989
Gastric stenosis 16.62 11.16 7 172157 66 50432894
Basal cell carcinoma 16.60 11.16 34 172130 23322 50409638
Affect lability 16.55 11.16 5 172159 8993 50423967
Gait apraxia 16.55 11.16 5 172159 15 50432945
Ventricular dysfunction 16.55 11.16 31 172133 2590 50430370
Drug dependence 16.53 11.16 26 172138 19733 50413227
Haematopoietic stem cell mobilisation 16.52 11.16 4 172160 3 50432957
Cytokine abnormal 16.52 11.16 4 172160 3 50432957
Rubulavirus test positive 16.52 11.16 4 172160 3 50432957
Chronic lymphocytic leukaemia 16.52 11.16 29 172135 2304 50430656
Lymphangitis 16.51 11.16 17 172147 803 50432157
Cryptosporidiosis infection 16.51 11.16 11 172153 279 50432681
Mycobacterium abscessus infection 16.47 11.16 14 172150 517 50432443
Paraneoplastic syndrome 16.43 11.16 14 172150 519 50432441
Fungal endocarditis 16.42 11.16 10 172154 216 50432744
Cardiac failure chronic 16.41 11.16 37 172127 3526 50429434
Cerebral aspergillosis 16.40 11.16 12 172152 355 50432605
Pregnancy 16.37 11.16 49 172115 29528 50403432
Hepatic necrosis 16.35 11.16 47 172117 5201 50427759
Lower respiratory tract infection fungal 16.34 11.16 11 172153 284 50432676
Post procedural infection 16.32 11.16 3 172161 7573 50425387
Pyomyositis 16.29 11.16 12 172152 359 50432601
Forced vital capacity decreased 16.28 11.16 18 172146 923 50432037
Retching 16.24 11.16 12 172152 12850 50420110
Lethargy 16.20 11.16 100 172064 49332 50383628
Central nervous system leukaemia 16.15 11.16 8 172156 113 50432847
Haemorrhage intracranial 16.13 11.16 84 172080 12290 50420670
Parkinsonism 16.13 11.16 5 172159 8842 50424118
Acinetobacter infection 16.10 11.16 22 172142 1405 50431555
Cerebellar haemangioma 16.09 11.16 7 172157 72 50432888
Haemolysis 16.03 11.16 51 172113 5965 50426995
Pharyngitis streptococcal 16.01 11.16 5 172159 8803 50424157
Pneumonia aspiration 16.01 11.16 53 172111 30951 50402009
Hemiparesis 16.01 11.16 120 172044 19928 50413032
Pulse waveform abnormal 16.00 11.16 7 172157 73 50432887
Human herpesvirus 7 infection 16.00 11.16 7 172157 73 50432887
High-grade B-cell lymphoma 15.99 11.16 4 172160 4 50432956
Neonatal lupus erythematosus 15.99 11.16 4 172160 4 50432956
Hypertriglyceridaemia 15.98 11.16 48 172116 5443 50427517
Toxic neuropathy 15.97 11.16 12 172152 370 50432590
Blood pressure abnormal 15.95 11.16 12 172152 12735 50420225
Premature baby 15.93 11.16 112 172052 18225 50414735
Disseminated tuberculosis 15.93 11.16 30 172134 2516 50430444
Pneumonia respiratory syncytial viral 15.93 11.16 15 172149 635 50432325
Metastases to uterus 15.92 11.16 7 172157 74 50432886
Ankle brachial index decreased 15.92 11.16 7 172157 74 50432886
Transient hypogammaglobulinaemia of infancy 15.91 11.16 6 172158 41 50432919
Blood fibrinogen decreased 15.91 11.16 15 172149 636 50432324
Haptoglobin decreased 15.83 11.16 15 172149 640 50432320
Pain in jaw 15.80 11.16 72 172092 38356 50394604
Onycholysis 15.78 11.16 21 172143 1307 50431653
Meningoencephalitis viral 15.78 11.16 11 172153 301 50432659
Microsporidia infection 15.72 11.16 10 172154 234 50432726
Coma 15.71 11.16 121 172043 56758 50376202
Pneumonia pneumococcal 15.69 11.16 24 172140 1699 50431261
Chronic lymphocytic leukaemia transformation 15.67 11.16 6 172158 43 50432917
Jejunal stenosis 15.67 11.16 6 172158 43 50432917
Soft tissue infection 15.66 11.16 25 172139 1837 50431123
Nail disorder 15.61 11.16 70 172094 9638 50423322
VIth nerve paresis 15.60 11.16 7 172157 78 50432882
Blast cell count increased 15.59 11.16 12 172152 384 50432576
Red blood cell schistocytes present 15.53 11.16 10 172154 239 50432721
Meningitis 15.51 11.16 51 172113 6070 50426890
Disorientation 15.49 11.16 65 172099 35419 50397541
Alopecia totalis 15.47 11.16 11 172153 311 50432649
Paraplegia 15.46 11.16 29 172135 2425 50430535
Metastases to heart 15.43 11.16 6 172158 45 50432915
Spinal cord compression 15.42 11.16 37 172127 3672 50429288
Rib fracture 15.42 11.16 26 172138 19195 50413765
Secretion discharge 15.39 11.16 7 172157 9784 50423176
Fungal oesophagitis 15.36 11.16 14 172150 568 50432392
Refractory cancer 15.36 11.16 7 172157 81 50432879
Eczema 15.34 11.16 34 172130 22668 50410292
Lymphocytic leukaemia 15.32 11.16 8 172156 127 50432833
Merycism 15.31 11.16 9 172155 182 50432778
Menopause 15.29 11.16 28 172136 2299 50430661
Metastatic lymphoma 15.29 11.16 7 172157 82 50432878
Congenital syphilitic osteochondritis 15.26 11.16 5 172159 21 50432939
Areflexia 15.26 11.16 31 172133 2749 50430211
Pneumonia staphylococcal 15.25 11.16 30 172134 2599 50430361
Immune thrombocytopenia 15.25 11.16 66 172098 8951 50424009
Duodenal stenosis 15.23 11.16 13 172151 483 50432477
Superior mesenteric artery syndrome 15.14 11.16 7 172157 84 50432876
Enterocolitis 15.13 11.16 53 172111 6514 50426446
Infusion site swelling 15.13 11.16 3 172161 7173 50425787
Pseudomonal bacteraemia 15.10 11.16 20 172144 1239 50431721
Non-Hodgkin's lymphoma recurrent 15.10 11.16 4 172160 6 50432954
Human herpes virus 8 test positive 15.10 11.16 4 172160 6 50432954
Hypotelorism of orbit 15.10 11.16 4 172160 6 50432954
Cutaneous mucormycosis 15.10 11.16 4 172160 6 50432954
Peritonitis viral 15.10 11.16 6 172158 48 50432912
Generalised oedema 15.09 11.16 89 172075 13642 50419318
Hepatic infarction 15.08 11.16 14 172150 582 50432378
Endocarditis bacterial 15.08 11.16 14 172150 582 50432378
Hepatic calcification 15.08 11.16 5 172159 22 50432938
Central nervous system enteroviral infection 15.08 11.16 5 172159 22 50432938
Median nerve injury 15.08 11.16 5 172159 22 50432938
Parvovirus infection 15.05 11.16 9 172155 188 50432772
Epidermal necrosis 15.03 11.16 17 172147 894 50432066
Listeria encephalitis 15.00 11.16 10 172154 254 50432706
Clostridium test positive 14.99 11.16 26 172138 2046 50430914
Movement disorder 14.94 11.16 23 172141 17609 50415351
Chromosome analysis abnormal 14.94 11.16 8 172156 134 50432826
Metaplasia 14.92 11.16 12 172152 410 50432550
PIK3CA-activated mutation 14.90 11.16 16 172148 794 50432166
Chronic cutaneous lupus erythematosus 14.83 11.16 8 172156 136 50432824
Diffuse large B-cell lymphoma stage IV 14.83 11.16 10 172154 259 50432701
Arachnoid cyst 14.80 11.16 9 172155 194 50432766
Hypogonadism 14.78 11.16 7 172157 89 50432871
Escherichia infection 14.77 11.16 75 172089 10866 50422094
Mucosal erosion 14.76 11.16 20 172144 1267 50431693
Abdominal pain 14.75 11.16 655 171509 235573 50197387
Klebsiella test positive 14.73 11.16 17 172147 914 50432046
Hallucination, visual 14.67 11.16 21 172143 16561 50416399
Diverticulum 14.61 11.16 9 172155 10605 50422355
Rhinorrhoea 14.59 11.16 109 172055 51474 50381486
Splenic infarction 14.59 11.16 22 172142 1538 50431422
Tachycardia induced cardiomyopathy 14.59 11.16 6 172158 53 50432907
Gas gangrene 14.58 11.16 7 172157 92 50432868
Pleurodesis 14.56 11.16 5 172159 25 50432935
Hiatus hernia 14.54 11.16 25 172139 18319 50414641
Oral candidiasis 14.51 11.16 103 172061 16812 50416148
Hyperproteinaemia 14.51 11.16 7 172157 93 50432867
Oral disorder 14.50 11.16 59 172105 7785 50425175
Pericarditis constrictive 14.48 11.16 11 172153 345 50432615
Blood immunoglobulin G decreased 14.48 11.16 25 172139 1960 50431000
Epstein-Barr virus infection reactivation 14.44 11.16 13 172151 519 50432441
Tracheo-oesophageal fistula 14.40 11.16 13 172151 521 50432439
Leukaemic infiltration 14.40 11.16 5 172159 26 50432934
Skin hypopigmentation 14.40 11.16 14 172150 617 50432343
Anal infection 14.39 11.16 6 172158 55 50432905
Akathisia 14.38 11.16 5 172159 8224 50424736
Anaesthesia 14.37 11.16 11 172153 349 50432611
Skin cancer 14.33 11.16 7 172157 9387 50423573
Venous haemorrhage 14.32 11.16 9 172155 206 50432754
Deafness 14.32 11.16 97 172067 15594 50417366
Mood swings 14.31 11.16 20 172144 15934 50417026
Eosinophilic fasciitis 14.31 11.16 7 172157 96 50432864
Mycobacterium chelonae infection 14.31 11.16 12 172152 435 50432525
Blood immunoglobulin A decreased 14.26 11.16 11 172153 353 50432607
Cardiac tamponade 14.26 11.16 39 172125 4193 50428767
Hypoperfusion 14.25 11.16 20 172144 1310 50431650
Gastritis fungal 14.25 11.16 7 172157 97 50432863
Artificial menopause 14.24 11.16 5 172159 27 50432933
Bladder disorder 14.23 11.16 4 172160 7539 50425421
Iron deficiency anaemia 14.23 11.16 22 172142 16812 50416148
Synovial cyst 14.21 11.16 5 172159 8161 50424799
Staphylococcus test positive 14.19 11.16 34 172130 3372 50429588
Joint effusion 14.18 11.16 14 172150 13007 50419953
Neutrophilia 14.16 11.16 35 172129 3540 50429420
Ovarian Sertoli-Leydig cell tumour 14.06 11.16 3 172161 0 50432960
Autologous haematopoietic stem cell transplant 14.06 11.16 3 172161 0 50432960
Atrial thrombosis 14.06 11.16 21 172143 1456 50431504
Endocrine ophthalmopathy 14.03 11.16 11 172153 362 50432598
Metastases to retroperitoneum 14.00 11.16 8 172156 153 50432807
Central nervous system viral infection 14.00 11.16 7 172157 101 50432859
Oedema due to cardiac disease 13.95 11.16 5 172159 29 50432931
Enterocolitis haemorrhagic 13.94 11.16 20 172144 1337 50431623
Cushingoid 13.93 11.16 52 172112 6593 50426367
Hypofibrinogenaemia 13.86 11.16 18 172146 1094 50431866
Clonal haematopoiesis 13.77 11.16 4 172160 10 50432950
Microangiopathy 13.77 11.16 16 172148 867 50432093
Hypoglossal nerve paresis 13.76 11.16 7 172157 105 50432855
Emotional disorder 13.74 11.16 12 172152 11824 50421136
Optic atrophy 13.73 11.16 18 172146 1104 50431856
Gastrointestinal mucormycosis 13.73 11.16 9 172155 222 50432738
Cytomegalovirus enterocolitis 13.69 11.16 13 172151 556 50432404
Leukaemic infiltration extramedullary 13.68 11.16 6 172158 63 50432897
Eye disorder 13.56 11.16 27 172137 18712 50414248
Stenotrophomonas sepsis 13.54 11.16 5 172159 32 50432928
Endocardial fibrosis 13.50 11.16 4 172160 11 50432949
Stenotrophomonas infection 13.48 11.16 22 172142 1647 50431313
Needle issue 13.46 11.16 4 172160 7271 50425689
Dementia 13.43 11.16 21 172143 15976 50416984
Pulmonary necrosis 13.30 11.16 7 172157 113 50432847
Peripheral T-cell lymphoma unspecified 13.30 11.16 8 172156 169 50432791
Neurological decompensation 13.29 11.16 26 172138 2244 50430716
Leukonychia 13.24 11.16 4 172160 12 50432948
Granulocyte count decreased 13.23 11.16 15 172149 791 50432169
Vitamin D decreased 13.23 11.16 6 172158 8400 50424560
Lymph node pain 13.18 11.16 19 172145 1276 50431684
Escherichia urinary tract infection 13.16 11.16 70 172094 10325 50422635
Jejunal ulcer perforation 13.16 11.16 5 172159 35 50432925
Paratracheal lymphadenopathy 13.16 11.16 5 172159 35 50432925
Electrocardiogram QT prolonged 13.13 11.16 113 172051 51773 50381187
Acute generalised exanthematous pustulosis 13.13 11.16 7 172157 8931 50424029
Trichodysplasia spinulosa 13.10 11.16 12 172152 490 50432470
Septic embolus 13.10 11.16 15 172149 800 50432160
Candida pneumonia 13.09 11.16 7 172157 117 50432843
Immunosuppression 13.05 11.16 55 172109 7371 50425589
Body height decreased 13.05 11.16 7 172157 8901 50424059
Musculoskeletal discomfort 13.05 11.16 19 172145 14879 50418081
Fungal skin infection 13.03 11.16 35 172129 3724 50429236
Acral peeling skin syndrome 13.00 11.16 4 172160 13 50432947
Coagulopathy 13.00 11.16 105 172059 17839 50415121
Metapneumovirus infection 12.99 11.16 15 172149 807 50432153
Lip and/or oral cavity cancer 12.99 11.16 10 172154 320 50432640
Respiratory depression 12.97 11.16 13 172151 11997 50420963
Metastases to abdominal cavity 12.95 11.16 11 172153 406 50432554
Papillary thyroid cancer 12.93 11.16 24 172140 1991 50430969
Injection site phlebitis 12.93 11.16 7 172157 120 50432840
Malnutrition 12.93 11.16 83 172081 13106 50419854
Pneumonia parainfluenzae viral 12.90 11.16 6 172158 73 50432887
Uterine enlargement 12.89 11.16 17 172147 1049 50431911
Metastases to spleen 12.88 11.16 7 172157 121 50432839
Liver function test abnormal 12.88 11.16 93 172071 44246 50388714
Aphasia 12.87 11.16 151 172013 28343 50404617
Blood phosphorus decreased 12.85 11.16 35 172129 3754 50429206
Cytomegalovirus gastritis 12.85 11.16 8 172156 180 50432780
Laryngitis 12.85 11.16 11 172153 10945 50422015
Monoparesis 12.79 11.16 20 172144 1444 50431516
Increased tendency to bruise 12.78 11.16 8 172156 9348 50423612
CD4/CD8 ratio decreased 12.78 11.16 4 172160 14 50432946
Evans syndrome 12.73 11.16 8 172156 183 50432777
Oral fungal infection 12.73 11.16 27 172137 2468 50430492
Chronic hepatitis 12.73 11.16 15 172149 825 50432135
Axillary vein thrombosis 12.73 11.16 10 172154 330 50432630
Spinal cord disorder 12.71 11.16 18 172146 1189 50431771
Radiation injury 12.70 11.16 11 172153 417 50432543
Acute interstitial pneumonitis 12.70 11.16 13 172151 610 50432350
Angina pectoris 12.69 11.16 46 172118 26142 50406818
Clostridium colitis 12.69 11.16 22 172142 1730 50431230
Psychomotor hyperactivity 12.64 11.16 8 172156 9293 50423667
Rectal fissure 12.63 11.16 12 172152 514 50432446
Bone sarcoma 12.57 11.16 4 172160 15 50432945
Retinitis viral 12.57 11.16 4 172160 15 50432945
Malignant ascites 12.54 11.16 15 172149 838 50432122
Scar 12.53 11.16 13 172151 11805 50421155
Tumour haemorrhage 12.52 11.16 19 172145 1336 50431624
Mitral valve disease 12.50 11.16 24 172140 2042 50430918
Blindness 12.48 11.16 101 172063 17168 50415792
Liver scan abnormal 12.48 11.16 5 172159 41 50432919
Ocular vasculitis 12.48 11.16 5 172159 41 50432919
Metastases to ovary 12.47 11.16 10 172154 340 50432620
Acute cutaneous lupus erythematosus 12.46 11.16 9 172155 261 50432699
Colitis ulcerative 12.44 11.16 24 172140 16830 50416130
Pulmonary vein stenosis 12.42 11.16 6 172158 80 50432880
Acute hepatitis C 12.42 11.16 6 172158 80 50432880
Chromaturia 12.39 11.16 19 172145 14571 50418389
Candida test positive 12.39 11.16 15 172149 849 50432111
Oesophagitis 12.37 11.16 83 172081 13300 50419660
Upper respiratory tract infection 12.37 11.16 154 172010 65744 50367216
Citrobacter infection 12.37 11.16 10 172154 344 50432616
Beta 2 microglobulin decreased 12.36 11.16 4 172160 16 50432944
Hepatic candidiasis 12.36 11.16 4 172160 16 50432944
Pulmonary vascular disorder 12.35 11.16 10 172154 345 50432615
Hallucination, auditory 12.31 11.16 11 172153 10717 50422243
Glomerulonephritis membranous 12.30 11.16 12 172152 531 50432429
Soft tissue inflammation 12.28 11.16 9 172155 267 50432693
Granulomatosis with polyangiitis 12.26 11.16 22 172142 1778 50431182
Atrioventricular block first degree 12.25 11.16 3 172161 6198 50426762
Xerophthalmia 12.22 11.16 10 172154 350 50432610
Hereditary motor and sensory neuropathy 12.22 11.16 6 172158 83 50432877
Ileus 12.20 11.16 82 172082 13147 50419813
Bladder perforation 12.20 11.16 7 172157 135 50432825
Low cardiac output syndrome 12.19 11.16 9 172155 270 50432690
Arteritis infective 12.17 11.16 5 172159 44 50432916
Cytokine storm 12.17 11.16 9 172155 271 50432689
Norovirus test positive 12.15 11.16 7 172157 136 50432824
Hemianopia 12.14 11.16 15 172149 867 50432093
Ovarian cyst 12.11 11.16 18 172146 13978 50418982
Tuberous sclerosis complex 12.10 11.16 6 172158 85 50432875
Stomatococcal infection 12.10 11.16 6 172158 85 50432875
Rotavirus infection 12.08 11.16 9 172155 274 50432686
Chronic lymphocytic leukaemia refractory 12.07 11.16 5 172159 45 50432915
Enterovirus test positive 12.06 11.16 7 172157 138 50432822
Oligohydramnios 12.05 11.16 45 172119 5705 50427255
Respiratory tract infection bacterial 12.04 11.16 8 172156 202 50432758
Large intestine perforation 12.02 11.16 54 172110 7440 50425520
Subretinal hyperreflective exudation 11.99 11.16 3 172161 3 50432957
Breast prosthesis removal 11.99 11.16 3 172161 3 50432957
Allogenic bone marrow transplantation therapy 11.99 11.16 3 172161 3 50432957
Li-Fraumeni syndrome 11.99 11.16 3 172161 3 50432957
Follicle centre lymphoma, follicular grade I, II, III stage IV 11.99 11.16 3 172161 3 50432957
Rosai-Dorfman syndrome 11.99 11.16 4 172160 18 50432942
Pleocytosis 11.99 11.16 12 172152 548 50432412
Anti-platelet antibody positive 11.98 11.16 5 172159 46 50432914
Leukostasis syndrome 11.98 11.16 5 172159 46 50432914
Neuromuscular toxicity 11.97 11.16 7 172157 140 50432820
Intercepted product administration error 11.97 11.16 6 172158 87 50432873
Epstein-Barr virus test positive 11.97 11.16 12 172152 549 50432411
Bone density decreased 11.95 11.16 12 172152 11063 50421897
Delusion 11.93 11.16 11 172153 10558 50422402
Tenosynovitis 11.92 11.16 11 172153 10554 50422406
Abdominal neoplasm 11.91 11.16 9 172155 280 50432680
Hydronephrosis 11.85 11.16 59 172105 8482 50424478
Chorioretinitis 11.83 11.16 11 172153 458 50432502
Head discomfort 11.82 11.16 12 172152 11007 50421953
Sputum discoloured 11.81 11.16 17 172147 13378 50419582
Skin ulcer 11.81 11.16 71 172093 35247 50397713
Obstructive airways disorder 11.81 11.16 22 172142 15630 50417330
Culture stool positive 11.80 11.16 9 172155 284 50432676
Scintillating scotoma 11.80 11.16 7 172157 144 50432816
Extramedullary haemopoiesis 11.79 11.16 5 172159 48 50432912
West Nile viral infection 11.77 11.16 10 172154 369 50432591
Blood glucose abnormal 11.76 11.16 4 172160 6668 50426292
Carotidynia 11.76 11.16 7 172157 145 50432815
Liver function test increased 11.75 11.16 46 172118 25560 50407400
Haemolytic uraemic syndrome 11.72 11.16 25 172139 2294 50430666
Hodgkin's disease 11.72 11.16 14 172150 781 50432179
Quadriparesis 11.72 11.16 21 172143 1695 50431265
Hypersensitivity pneumonitis 11.70 11.16 25 172139 2297 50430663
Adenocarcinoma 11.69 11.16 26 172138 2455 50430505
Cachexia 11.69 11.16 38 172126 4495 50428465
Dandy-Walker syndrome 11.67 11.16 6 172158 92 50432868
Malignant neoplasm of orbit 11.65 11.16 4 172160 20 50432940
Lymphatic obstruction 11.65 11.16 4 172160 20 50432940
Ureteritis 11.65 11.16 4 172160 20 50432940
Periorbital cellulitis 11.62 11.16 12 172152 569 50432391
Speech disorder 11.61 11.16 72 172092 35476 50397484
Live birth 11.57 11.16 24 172140 16384 50416576
COVID-19 11.55 11.16 223 171941 46439 50386521
Haemodynamic instability 11.54 11.16 56 172108 7968 50424992
Viral myelitis 11.53 11.16 3 172161 4 50432956
Febrile convulsion 11.53 11.16 10 172154 380 50432580
Neuroblastoma recurrent 11.49 11.16 4 172160 21 50432939
CSF cell count increased 11.49 11.16 4 172160 21 50432939
Night sweats 11.49 11.16 67 172097 33507 50399453
Scoliosis 11.49 11.16 4 172160 6572 50426388
Dental caries 11.46 11.16 10 172154 9857 50423103
Antineutrophil cytoplasmic antibody increased 11.44 11.16 5 172159 52 50432908
Subacute combined cord degeneration 11.41 11.16 8 172156 221 50432739
Remission not achieved 11.39 11.16 6 172158 97 50432863
Gastrointestinal haemorrhage 11.39 11.16 178 171986 73143 50359817
Tinnitus 11.39 11.16 53 172111 28079 50404881
Upper limb fracture 11.37 11.16 23 172141 15850 50417110
Herpes simplex reactivation 11.37 11.16 10 172154 387 50432573
Blood pressure systolic abnormal 11.37 11.16 6 172158 7700 50425260
Plasmodium falciparum infection 11.34 11.16 4 172160 22 50432938
HER2 positive breast cancer 11.33 11.16 9 172155 302 50432658
Meningoencephalitis herpetic 11.31 11.16 16 172148 1056 50431904
Erythropenia 11.30 11.16 7 172157 156 50432804
Intra-abdominal haemorrhage 11.30 11.16 24 172140 2196 50430764
Herpes simplex encephalitis 11.30 11.16 9 172155 303 50432657
Osmotic demyelination syndrome 11.30 11.16 12 172152 588 50432372
Intracranial pressure increased 11.29 11.16 36 172128 4216 50428744
Cerebral fungal infection 11.28 11.16 5 172159 54 50432906
Ocular lymphoma 11.28 11.16 5 172159 54 50432906
Vulvovaginal inflammation 11.26 11.16 12 172152 590 50432370
Muscle tightness 11.25 11.16 11 172153 10269 50422691
Back injury 11.24 11.16 5 172159 7080 50425880
Growth retardation 11.24 11.16 16 172148 1062 50431898
Intraductal proliferative breast lesion 11.21 11.16 26 172138 2524 50430436
Pseudomyopia 11.20 11.16 5 172159 55 50432905
Magnetic resonance imaging head abnormal 11.20 11.16 21 172143 1756 50431204
Corynebacterium sepsis 11.19 11.16 4 172160 23 50432937
Human rhinovirus test positive 11.19 11.16 7 172157 159 50432801
Pericardial effusion malignant 11.18 11.16 6 172158 101 50432859
Water intoxication 11.18 11.16 10 172154 396 50432564
Cytomegalovirus hepatitis 11.17 11.16 9 172155 308 50432652
Tachycardia 11.16 11.16 430 171734 99333 50333627

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 3893.76 11.93 3648 138710 108592 29323577
Neutropenia 1390.46 11.93 2363 139995 129348 29302821
Product use in unapproved indication 1255.22 11.93 1802 140556 85073 29347096
Cytokine release syndrome 1243.20 11.93 779 141579 12340 29419829
Acute graft versus host disease 783.61 11.93 434 141924 5390 29426779
Myelosuppression 765.86 11.93 562 141796 11665 29420504
Bone marrow failure 747.44 11.93 785 141573 26664 29405505
Myelodysplastic syndrome 746.00 11.93 646 141712 17148 29415021
Mucosal inflammation 727.11 11.93 827 141531 30768 29401401
Cytomegalovirus infection 708.42 11.93 706 141652 22509 29409660
Hepatitis B 705.14 11.93 397 141961 5100 29427069
Hypogammaglobulinaemia 694.43 11.93 403 141955 5504 29426665
Progressive multifocal leukoencephalopathy 652.98 11.93 447 141911 8272 29423897
Off label use 648.63 11.93 3009 139349 297791 29134378
Cystitis haemorrhagic 632.76 11.93 354 142004 4488 29427681
Haematotoxicity 624.87 11.93 394 141964 6305 29425864
Diffuse large B-cell lymphoma recurrent 569.27 11.93 269 142089 2328 29429841
Chronic graft versus host disease 544.06 11.93 301 142057 3728 29428441
Graft versus host disease 528.45 11.93 409 141949 9219 29422950
Acute myeloid leukaemia 523.74 11.93 513 141845 16000 29416169
Cytopenia 513.40 11.93 406 141952 9453 29422716
Pyrexia 498.11 11.93 2706 139652 284916 29147253
Second primary malignancy 495.55 11.93 341 142017 6364 29425805
Pancytopenia 490.44 11.93 1173 141185 81995 29350174
Venoocclusive liver disease 474.35 11.93 336 142022 6581 29425588
Acute graft versus host disease in skin 444.22 11.93 278 142080 4386 29427783
Hepatitis B reactivation 429.87 11.93 239 142119 2990 29429179
Completed suicide 403.36 11.93 6 142352 90240 29341929
Pneumocystis jirovecii pneumonia 402.49 11.93 449 141909 16330 29415839
Fall 389.78 11.93 183 142175 176995 29255174
Neutrophil count decreased 381.24 11.93 722 141636 42845 29389324
Thrombocytopenia 375.88 11.93 1461 140897 133362 29298807
Posterior reversible encephalopathy syndrome 368.24 11.93 322 142036 8654 29423515
Tumour lysis syndrome 365.15 11.93 390 141968 13494 29418675
Neurotoxicity 350.41 11.93 391 141967 14222 29417947
Disease progression 348.95 11.93 1024 141334 80892 29351277
Venoocclusive disease 343.66 11.93 190 142168 2349 29429820
Neutropenic sepsis 325.45 11.93 339 142019 11388 29420781
Febrile bone marrow aplasia 324.47 11.93 275 142083 7076 29425093
Product dose omission issue 316.92 11.93 44 142314 96339 29335830
Drug interaction 301.17 11.93 304 142054 197081 29235088
Adenovirus infection 300.23 11.93 214 142144 4233 29427936
Sepsis 297.95 11.93 1417 140941 141265 29290904
Epstein-Barr virus infection 290.56 11.93 247 142111 6382 29425787
Dizziness 288.38 11.93 293 142065 189391 29242778
Arthralgia 284.79 11.93 159 142199 139458 29292711
BK virus infection 269.29 11.93 205 142153 4502 29427667
Cytomegalovirus infection reactivation 267.39 11.93 179 142179 3185 29428984
Haemophagocytic lymphohistiocytosis 265.56 11.93 289 142069 10215 29421954
Diffuse large B-cell lymphoma 257.13 11.93 225 142133 6051 29426118
Leukopenia 255.20 11.93 711 141647 54492 29377677
Septic shock 246.38 11.93 761 141597 61799 29370370
Myocardial infarction 245.25 11.93 112 142246 110184 29321985
Therapy partial responder 242.90 11.93 201 142157 4998 29427171
White blood cell count decreased 239.78 11.93 913 141445 82449 29349720
Overdose 230.61 11.93 51 142307 79768 29352401
Fatigue 229.47 11.93 772 141586 316049 29116120
Post transplant lymphoproliferative disorder 227.19 11.93 198 142160 5295 29426874
Lymphopenia 226.57 11.93 302 142056 13231 29418938
Graft versus host disease in skin 224.41 11.93 161 142197 3218 29428951
Aspergillus infection 223.14 11.93 265 142093 10316 29421853
Disease recurrence 220.06 11.93 324 142034 15590 29416579
Acute lymphocytic leukaemia recurrent 214.82 11.93 140 142218 2376 29429793
Pain 212.63 11.93 310 142048 171122 29261047
Anxiety 210.45 11.93 74 142284 85291 29346878
Cardiotoxicity 208.39 11.93 177 142181 4567 29427602
Graft versus host disease in gastrointestinal tract 202.20 11.93 149 142209 3109 29429060
Dyspnoea 200.93 11.93 851 141507 325881 29106288
Rhabdomyolysis 194.61 11.93 30 142328 60778 29371391
Multiple organ dysfunction syndrome 193.69 11.93 706 141652 62410 29369759
Thrombotic microangiopathy 189.00 11.93 221 142137 8460 29423709
Malaise 185.98 11.93 301 142057 159301 29272868
Platelet count decreased 184.72 11.93 992 141366 103680 29328489
Insomnia 183.87 11.93 99 142259 88662 29343507
Cytomegalovirus chorioretinitis 182.98 11.93 140 142218 3098 29429071
Bronchopulmonary aspergillosis 181.87 11.93 259 142099 12085 29420084
Rash 176.85 11.93 409 141949 189410 29242759
Diffuse large B-cell lymphoma refractory 176.35 11.93 87 142271 835 29431334
Acquired gene mutation 172.61 11.93 95 142263 1163 29431006
Immune effector cell-associated neurotoxicity syndrome 171.22 11.93 101 142257 1423 29430746
Lymphadenopathy 166.78 11.93 371 141987 24678 29407491
Death 166.01 11.93 968 141390 341116 29091053
Neoplasm progression 158.40 11.93 305 142053 18307 29413862
Somnolence 154.40 11.93 135 142223 93820 29338349
Blood pressure increased 153.30 11.93 82 142276 73721 29358448
Depression 152.87 11.93 112 142246 85035 29347134
Infection 148.88 11.93 747 141611 76004 29356165
Pruritus 147.99 11.93 208 142150 116641 29315528
Muscle spasms 146.27 11.93 65 142293 65017 29367152
Acute graft versus host disease in intestine 145.14 11.93 107 142251 2234 29429935
Feeling abnormal 143.34 11.93 42 142316 54403 29377766
Joint swelling 142.72 11.93 32 142326 49598 29382571
Suicidal ideation 141.24 11.93 6 142352 34710 29397459
B-cell lymphoma recurrent 141.05 11.93 66 142292 557 29431612
Pain in extremity 139.42 11.93 197 142161 110236 29321933
Mantle cell lymphoma recurrent 138.84 11.93 61 142297 437 29431732
Lymphocyte count decreased 138.05 11.93 294 142064 18977 29413192
Inappropriate schedule of product administration 137.68 11.93 24 142334 44448 29387721
Suicide attempt 135.19 11.93 7 142351 34103 29398066
Herpes simplex 135.00 11.93 141 142217 4749 29427420
Malignant neoplasm progression 134.98 11.93 707 141651 73152 29359017
Peripheral swelling 133.57 11.93 70 142288 63669 29368500
Respiratory failure 133.43 11.93 862 141496 96269 29335900
Aggression 132.77 11.93 10 142348 35531 29396638
Cytomegalovirus viraemia 131.13 11.93 157 142201 6163 29426006
Gait disturbance 130.98 11.93 97 142261 73252 29358917
Blood glucose increased 129.29 11.93 61 142297 58923 29373246
Neuropathy peripheral 127.11 11.93 676 141682 70351 29361818
Cerebrovascular accident 125.75 11.93 111 142247 76800 29355369
JC virus infection 125.08 11.93 90 142268 1807 29430362
Chest pain 124.02 11.93 218 142140 111755 29320414
Intentional product misuse 120.75 11.93 13 142345 34648 29397521
B-cell type acute leukaemia 120.48 11.93 47 142311 238 29431931
Drug resistance 120.43 11.93 298 142060 21242 29410927
Coronary artery disease 120.21 11.93 32 142326 44158 29388011
Fungal infection 118.58 11.93 226 142132 13459 29418710
Stem cell transplant 116.88 11.93 88 142270 1899 29430270
Viral haemorrhagic cystitis 115.43 11.93 66 142292 874 29431295
Neoplasm recurrence 115.06 11.93 87 142271 1890 29430279
Myalgia 114.89 11.93 112 142246 73907 29358262
Asthenia 112.33 11.93 594 141764 214656 29217513
Headache 112.33 11.93 444 141914 173563 29258606
Weight increased 112.21 11.93 122 142236 76545 29355624
Toxicity to various agents 112.18 11.93 443 141915 173218 29258951
Hospitalisation 111.34 11.93 41 142317 45947 29386222
Hypoglycaemia 110.65 11.93 47 142311 48299 29383870
Loss of consciousness 109.33 11.93 117 142241 73939 29358230
Epstein-Barr virus associated lymphoproliferative disorder 109.01 11.93 80 142278 1658 29430511
Aplasia 108.32 11.93 115 142243 3948 29428221
Candida infection 107.57 11.93 231 142127 14994 29417175
Psoriasis 107.52 11.93 14 142344 32213 29399956
Sweat gland tumour 106.94 11.93 48 142310 364 29431805
Systemic mycosis 106.69 11.93 71 142287 1250 29430919
Injection site pain 106.11 11.93 15 142343 32431 29399738
Pseudomonas infection 105.07 11.93 188 142170 10664 29421505
Hallucination 104.70 11.93 42 142316 44670 29387499
Musculoskeletal stiffness 104.04 11.93 26 142332 37432 29394737
Polyneuropathy 103.22 11.93 199 142159 11953 29420216
Cystitis viral 102.60 11.93 50 142308 466 29431703
Hyperhidrosis 100.92 11.93 97 142261 64443 29367726
Bacteraemia 97.85 11.93 232 142126 16091 29416078
Engraftment syndrome 95.05 11.93 56 142302 787 29431382
Pneumonia cytomegaloviral 93.83 11.93 88 142270 2594 29429575
Chronic graft versus host disease in skin 93.66 11.93 55 142303 768 29431401
Human herpesvirus 6 infection 93.27 11.93 75 142283 1788 29430381
Weight decreased 92.37 11.93 393 141965 150512 29281657
Nausea 92.33 11.93 919 141439 288336 29143833
Drug hypersensitivity 91.37 11.93 117 142241 68289 29363880
Nasopharyngitis 90.60 11.93 92 142266 59573 29372596
Hepatic failure 90.32 11.93 345 142013 31167 29401002
Stress 89.86 11.93 3 142355 21487 29410682
Minimal residual disease 89.16 11.93 40 142318 303 29431866
Wrong technique in product usage process 88.87 11.93 21 142337 31407 29400762
Autoimmune haemolytic anaemia 88.86 11.93 101 142257 3747 29428422
Lymphoproliferative disorder 88.57 11.93 83 142275 2444 29429725
Chronic lymphocytic leukaemia recurrent 88.54 11.93 41 142317 337 29431832
End stage renal disease 87.68 11.93 143 142215 7521 29424648
Transplant failure 87.29 11.93 87 142271 2769 29429400
Chest discomfort 87.11 11.93 57 142301 45926 29386243
Escherichia sepsis 85.06 11.93 100 142258 3849 29428320
Blood creatine phosphokinase increased 84.59 11.93 45 142313 40599 29391570
Cytomegalovirus test positive 84.45 11.93 93 142265 3330 29428839
Rheumatoid arthritis 84.25 11.93 25 142333 32127 29400042
Escherichia infection 83.97 11.93 131 142227 6633 29425536
Diarrhoea 83.60 11.93 1115 141243 331583 29100586
Bacterial sepsis 83.41 11.93 108 142250 4595 29427574
Back pain 83.04 11.93 236 142122 102048 29330121
Chronic obstructive pulmonary disease 82.83 11.93 47 142311 40908 29391261
Incorrect dose administered 82.24 11.93 28 142330 32956 29399213
Urticaria 82.18 11.93 85 142273 54575 29377594
Agranulocytosis 81.41 11.93 249 142109 20091 29412078
Cardiac failure congestive 81.25 11.93 153 142205 76428 29355741
Hyperkalaemia 80.96 11.93 106 142252 61286 29370883
Loss of personal independence in daily activities 80.34 11.93 13 142345 25427 29406742
Mucormycosis 80.08 11.93 111 142247 5047 29427122
International normalised ratio increased 80.06 11.93 58 142300 44314 29387855
Abdominal discomfort 79.64 11.93 68 142290 47835 29384334
Bradycardia 78.92 11.93 121 142237 65508 29366661
Acute graft versus host disease in liver 78.13 11.93 59 142299 1279 29430890
Pneumonia 78.12 11.93 2054 140304 318118 29114051
Infection reactivation 77.28 11.93 54 142304 1033 29431136
Confusional state 76.41 11.93 336 142022 127541 29304628
Plasma cell myeloma recurrent 75.60 11.93 91 142267 3592 29428577
Leukoencephalopathy 75.57 11.93 92 142266 3675 29428494
Osteonecrosis 74.47 11.93 186 142172 13333 29418836
Heart rate decreased 73.77 11.93 15 142343 24897 29407272
Plasmacytoma 73.58 11.93 84 142274 3131 29429038
Enterococcal infection 73.43 11.93 138 142220 8130 29424039
Therapy non-responder 73.18 11.93 319 142039 30592 29401577
Syncope 72.67 11.93 179 142179 81192 29350977
Klebsiella infection 72.02 11.93 128 142230 7221 29424948
Pneumonia fungal 71.87 11.93 112 142246 5665 29426504
Sedation 70.81 11.93 3 142355 17402 29414767
Nephropathy toxic 70.10 11.93 158 142200 10598 29421571
Contusion 69.92 11.93 31 142327 31064 29401105
Stomatitis 69.62 11.93 358 142000 36755 29395414
Acute lymphocytic leukaemia 67.55 11.93 73 142285 2558 29429611
Leukaemia recurrent 64.64 11.93 55 142303 1422 29430747
Bacterial infection 62.95 11.93 170 142188 12778 29419391
Accidental overdose 62.82 11.93 6 142352 17587 29414582
Clostridium difficile colitis 62.77 11.93 172 142186 13040 29419129
Injury 61.81 11.93 9 142349 19037 29413132
Balance disorder 61.78 11.93 50 142308 36120 29396049
Chronic graft versus host disease in liver 61.39 11.93 31 142327 314 29431855
Agitation 61.28 11.93 95 142263 51209 29380960
Angioedema 61.20 11.93 39 142319 31876 29400293
Abnormal behaviour 60.56 11.93 18 142340 23109 29409060
Electrocardiogram QT prolonged 60.43 11.93 51 142307 36086 29396083
Arthropathy 59.77 11.93 15 142343 21539 29410630
Product prescribing error 59.50 11.93 8 142350 17968 29414201
Tremor 59.41 11.93 170 142188 73368 29358801
Graft versus host disease in liver 59.27 11.93 46 142312 1040 29431129
Mobility decreased 59.07 11.93 25 142333 25755 29406414
Anaplastic lymphoma kinase gene mutation 59.02 11.93 22 142336 96 29432073
Cytogenetic abnormality 58.96 11.93 41 142317 778 29431391
Refractory cytopenia with multilineage dysplasia 58.87 11.93 23 142335 117 29432052
Asthma 58.81 11.93 46 142312 33803 29398366
Blood stem cell transplant failure 58.55 11.93 32 142326 386 29431783
Cerebral toxoplasmosis 58.46 11.93 51 142307 1365 29430804
Drug dependence 57.41 11.93 15 142343 20966 29411203
Peripheral T-cell lymphoma unspecified 57.35 11.93 32 142326 403 29431766
Refractory anaemia with an excess of blasts 57.29 11.93 31 142327 366 29431803
Sleep disorder 56.93 11.93 23 142335 24363 29407806
Staphylococcal sepsis 56.44 11.93 129 142229 8733 29423436
Heart rate increased 55.80 11.93 63 142295 38875 29393294
Nephrolithiasis 55.80 11.93 26 142332 25308 29406861
Rhinovirus infection 55.71 11.93 73 142285 3143 29429026
Staphylococcal bacteraemia 55.37 11.93 112 142246 6967 29425202
Product quality issue 55.26 11.93 6 142352 15889 29416280
Neutropenic colitis 55.19 11.93 63 142295 2348 29429821
Hypersensitivity 54.95 11.93 107 142251 52796 29379373
Myelopathy 54.63 11.93 57 142301 1917 29430252
Pseudomonal sepsis 54.44 11.93 69 142289 2873 29429296
Dry skin 54.38 11.93 22 142336 23285 29408884
Device related infection 54.01 11.93 182 142176 15454 29416715
Fusarium infection 53.91 11.93 42 142316 955 29431214
Unevaluable event 53.87 11.93 39 142319 29812 29402357
Enterovirus infection 53.74 11.93 36 142322 641 29431528
Central nervous system lymphoma 53.44 11.93 37 142321 697 29431472
Hepatotoxicity 53.16 11.93 198 142160 17669 29414500
Psychotic disorder 53.00 11.93 16 142342 20338 29411831
Klebsiella sepsis 52.76 11.93 52 142306 1632 29430537
Microsporidia infection 52.20 11.93 33 142325 530 29431639
Flushing 52.16 11.93 38 142320 28954 29403215
Interstitial lung disease 51.93 11.93 464 141894 57254 29374915
Wheezing 51.89 11.93 50 142308 33190 29398979
Treatment noncompliance 51.63 11.93 26 142332 24201 29407968
Abdominal pain upper 51.50 11.93 138 142220 60855 29371314
Chloroma 51.45 11.93 31 142327 455 29431714
Malignant transformation 51.43 11.93 38 142320 796 29431373
Encephalopathy 51.13 11.93 289 142069 30754 29401415
Heart rate irregular 51.01 11.93 3 142355 13114 29419055
Bone marrow transplant rejection 50.74 11.93 23 142335 179 29431990
Lung infiltration 50.73 11.93 148 142210 11631 29420538
Osteosarcoma 50.63 11.93 23 142335 180 29431989
Cardiac disorder 50.50 11.93 63 142295 37200 29394969
Epstein-Barr virus infection reactivation 50.29 11.93 32 142326 520 29431649
Central nervous system fungal infection 50.25 11.93 27 142331 314 29431855
Memory impairment 50.12 11.93 61 142297 36409 29395760
Skin toxicity 49.57 11.93 75 142283 3696 29428473
Pneumonitis 49.48 11.93 266 142092 27778 29404391
Enterococcal bacteraemia 49.27 11.93 48 142310 1485 29430684
Strongyloidiasis 48.89 11.93 58 142300 2254 29429915
Azoospermia 48.56 11.93 28 142330 377 29431792
Gastrooesophageal reflux disease 48.44 11.93 48 142310 31448 29400721
Restlessness 48.35 11.93 23 142335 22122 29410047
Primary hypogonadism 47.98 11.93 17 142341 62 29432107
Respiratory arrest 47.60 11.93 33 142325 25800 29406369
Dehydration 47.04 11.93 341 142017 114407 29317762
Drug ineffective for unapproved indication 46.95 11.93 163 142195 14051 29418118
Lymphoma 46.74 11.93 128 142230 9700 29422469
Disseminated intravascular coagulation 46.37 11.93 205 142153 19775 29412394
Herpes virus infection 46.26 11.93 59 142299 2472 29429697
Recurrent cancer 46.18 11.93 41 142317 1124 29431045
Toxoplasmosis 46.12 11.93 41 142317 1126 29431043
Epstein-Barr viraemia 46.07 11.93 38 142320 940 29431229
Human polyomavirus infection 46.05 11.93 33 142325 658 29431511
Erythema 45.51 11.93 198 142160 75408 29356761
Candida sepsis 45.47 11.93 40 142318 1083 29431086
Swelling 45.40 11.93 62 142296 35221 29396948
Varicella zoster virus infection 45.38 11.93 45 142313 1423 29430746
Gastrointestinal haemorrhage 45.05 11.93 213 142145 79320 29352849
Injection site erythema 44.36 11.93 7 142351 13949 29418220
Pulmonary toxicity 43.89 11.93 82 142276 4808 29427361
Cardio-respiratory arrest 43.84 11.93 113 142245 50488 29381681
Labelled drug-drug interaction medication error 43.81 11.93 4 142354 12155 29420014
Parainfluenzae virus infection 43.61 11.93 54 142304 2195 29429974
Decreased appetite 43.24 11.93 469 141889 144873 29287296
Nocardiosis 43.08 11.93 65 142293 3195 29428974
Head injury 43.05 11.93 12 142346 16069 29416100
Peripheral sensory neuropathy 42.97 11.93 91 142267 5848 29426321
Oedema peripheral 42.80 11.93 307 142051 103250 29328919
Nervousness 42.74 11.93 3 142355 11303 29420866
Pneumonia klebsiella 42.70 11.93 58 142300 2586 29429583
Pleural effusion 42.49 11.93 531 141827 71377 29360792
Cardiomyopathy 42.44 11.93 162 142196 14625 29417544
Capillary leak syndrome 42.42 11.93 49 142309 1850 29430319
Pneumocystis jirovecii infection 42.22 11.93 43 142315 1405 29430764
Febrile infection 41.92 11.93 50 142308 1954 29430215
Cardiac arrest 41.87 11.93 241 142117 85350 29346819
Faeces discoloured 41.76 11.93 7 142351 13344 29418825
Blood pressure fluctuation 41.42 11.93 22 142336 19872 29412297
Encephalitis 41.39 11.93 94 142264 6336 29425833
Herpes zoster 41.35 11.93 267 142091 29785 29402384
Constipation 41.32 11.93 351 142007 113809 29318360
Psoriatic arthropathy 41.17 11.93 10 142348 14681 29417488
5q minus syndrome 40.96 11.93 18 142340 129 29432040
Depressed mood 40.93 11.93 14 142344 16434 29415735
Adenoviral haemorrhagic cystitis 40.85 11.93 25 142333 378 29431791
Anger 40.85 11.93 3 142355 10887 29421282
Osteoarthritis 40.77 11.93 18 142340 18085 29414084
Bone marrow infiltration 40.54 11.93 17 142341 107 29432062
Multiple sclerosis relapse 40.49 11.93 4 142354 11415 29420754
Staphylococcal infection 40.36 11.93 260 142098 28980 29403189
Vertigo 40.18 11.93 28 142330 21833 29410336
Clostridium difficile infection 40.06 11.93 169 142189 15972 29416197
Hot flush 39.99 11.93 11 142347 14859 29417310
Anaemia 39.90 11.93 1257 141101 199694 29232475
Respiratory tract infection fungal 39.70 11.93 30 142328 651 29431518
Bone marrow necrosis 39.64 11.93 17 142341 114 29432055
Treatment failure 39.63 11.93 309 142049 36630 29395539
Metabolic acidosis 39.26 11.93 76 142282 37586 29394583
Road traffic accident 39.15 11.93 13 142345 15548 29416621
Haematochezia 39.10 11.93 74 142284 36909 29395260
Liver function test abnormal 39.07 11.93 49 142309 28869 29403300
Chronic myeloid leukaemia 38.87 11.93 48 142310 1946 29430223
Clear cell renal cell carcinoma 38.81 11.93 35 142323 980 29431189
Blood lactate dehydrogenase increased 38.62 11.93 189 142169 19020 29413149
Irritability 38.61 11.93 30 142328 22122 29410047
Blood glucose decreased 38.48 11.93 6 142352 12063 29420106
Prostatic specific antigen increased 38.39 11.93 7 142351 12557 29419612
Autoimmune neutropenia 38.37 11.93 21 142337 254 29431915
Guillain-Barre syndrome 38.34 11.93 79 142279 4979 29427190
Lymphoma transformation 38.26 11.93 18 142340 154 29432015
Synovitis 38.14 11.93 4 142354 10886 29421283
B-cell lymphoma refractory 38.09 11.93 17 142341 127 29432042
Lactic acidosis 38.07 11.93 54 142304 30193 29401976
Gene mutation 38.05 11.93 35 142323 1006 29431163
Nightmare 37.98 11.93 5 142353 11412 29420757
Colitis 37.84 11.93 269 142089 30979 29401190
Blood fibrinogen decreased 37.77 11.93 33 142325 885 29431284
Human herpesvirus 6 encephalitis 37.75 11.93 19 142339 191 29431978
Adenovirus reactivation 37.72 11.93 16 142342 104 29432065
Thymus enlargement 37.66 11.93 13 142345 43 29432126
Therapeutic product effect decreased 37.64 11.93 52 142306 29399 29402770
Plasma cell leukaemia 37.61 11.93 31 142327 766 29431403
Acute myelomonocytic leukaemia 37.47 11.93 16 142342 106 29432063
Surgery 37.23 11.93 6 142352 11773 29420396
Swollen tongue 37.13 11.93 7 142351 12259 29419910
Musculoskeletal pain 37.12 11.93 51 142307 28902 29403267
Multiple-drug resistance 37.02 11.93 67 142291 3833 29428336
Aplastic anaemia 36.90 11.93 99 142259 7411 29424758
Hepatosplenomegaly 36.75 11.93 65 142293 3652 29428517
Dyspepsia 36.72 11.93 55 142303 30070 29402099
Amnesia 36.59 11.93 33 142325 22610 29409559
Acute myeloid leukaemia recurrent 36.56 11.93 44 142314 1736 29430433
Polyomavirus viraemia 36.53 11.93 28 142330 621 29431548
Dyskinesia 36.47 11.93 26 142332 20035 29412134
B-cell aplasia 36.36 11.93 15 142343 90 29432079
Myelitis transverse 36.35 11.93 33 142325 932 29431237
Transient ischaemic attack 36.32 11.93 35 142323 23235 29408934
Neck pain 36.18 11.93 30 142328 21417 29410752
Systemic candida 36.13 11.93 55 142303 2725 29429444
Peritonitis pneumococcal 36.11 11.93 11 142347 21 29432148
Emotional distress 36.04 11.93 11 142347 13884 29418285
Neuroblastoma 35.57 11.93 16 142342 122 29432047
Palpitations 35.56 11.93 64 142294 32540 29399629
Engraft failure 35.10 11.93 23 142335 394 29431775
Abdominal distension 35.00 11.93 109 142249 45802 29386367
Escherichia bacteraemia 34.98 11.93 55 142303 2803 29429366
Pulmonary vascular disorder 34.93 11.93 26 142332 551 29431618
Delusion 34.82 11.93 6 142352 11210 29420959
Influenza like illness 34.61 11.93 40 142318 24430 29407739
Respiratory depression 34.55 11.93 11 142347 13512 29418657
Blood pressure systolic increased 34.53 11.93 19 142339 16826 29415343
Myocardial ischaemia 34.45 11.93 17 142341 16011 29416158
Meningoencephalitis herpetic 34.40 11.93 29 142329 740 29431429
Medication error 34.17 11.93 31 142327 21180 29410989
Human herpesvirus 8 infection 33.95 11.93 30 142328 817 29431352
Respirovirus test positive 33.78 11.93 13 142345 63 29432106
Paranoia 33.65 11.93 4 142354 9873 29422296
Complications of bone marrow transplant 33.60 11.93 18 142340 208 29431961
Encephalitis enteroviral 33.60 11.93 16 142342 141 29432028
Myeloid leukaemia 33.45 11.93 21 142337 333 29431836
Colitis ulcerative 33.32 11.93 10 142348 12759 29419410
Drug reaction with eosinophilia and systemic symptoms 33.26 11.93 52 142306 27940 29404229
Acute promyelocytic leukaemia 33.23 11.93 23 142335 433 29431736
Acute kidney injury 33.23 11.93 998 141360 264269 29167900
Diabetic ketoacidosis 33.13 11.93 18 142340 16055 29416114
Ventricular tachycardia 32.91 11.93 36 142322 22538 29409631
B-lymphocyte count abnormal 32.88 11.93 9 142349 9 29432160
Coma 32.73 11.93 90 142268 39360 29392809
Epstein-Barr virus associated lymphoma 32.60 11.93 25 142333 555 29431614
Traumatic lung injury 32.52 11.93 34 142324 1146 29431023
Unresponsive to stimuli 32.48 11.93 44 142314 25082 29407087
Meningitis cryptococcal 32.31 11.93 45 142313 2055 29430114
Gastritis bacterial 32.30 11.93 17 142341 189 29431980
Obliterative bronchiolitis 32.28 11.93 33 142325 1083 29431086
Pneumomediastinum 32.20 11.93 41 142317 1715 29430454
Respiratory tract infection 32.19 11.93 155 142203 15496 29416673
Acute myocardial infarction 32.18 11.93 122 142236 48316 29383853
Hallucination, visual 32.16 11.93 16 142342 14999 29417170
Adverse drug reaction 32.13 11.93 41 142317 23979 29408190
Flatulence 32.13 11.93 23 142335 17686 29414483
Graft versus host disease in eye 32.10 11.93 18 142340 229 29431940
Paraparesis 32.05 11.93 41 142317 1723 29430446
Fear 32.01 11.93 4 142354 9500 29422669
Out of specification test results 31.89 11.93 10 142348 22 29432147
Erectile dysfunction 31.88 11.93 24 142334 17985 29414184
Pulmonary arteriopathy 31.79 11.93 13 142345 76 29432093
Adverse event 31.70 11.93 17 142341 15274 29416895
Primary amyloidosis 31.66 11.93 14 142344 102 29432067
Vision blurred 31.61 11.93 94 142264 40082 29392087
Therapy cessation 31.60 11.93 15 142343 14447 29417722
Type 2 diabetes mellitus 31.39 11.93 13 142345 13568 29418601
H1N1 influenza 31.31 11.93 29 142329 841 29431328
Glioblastoma multiforme 31.26 11.93 26 142332 651 29431518
Nasal cavity cancer 31.23 11.93 15 142343 135 29432034
Extrapyramidal disorder 31.09 11.93 7 142351 10824 29421345
Dysgeusia 31.07 11.93 38 142320 22636 29409533
Chronic lymphocytic leukaemia transformation 30.71 11.93 16 142342 174 29431995
Pneumonia respiratory syncytial viral 30.69 11.93 28 142330 796 29431373
Oxygen saturation decreased 30.63 11.93 112 142246 44825 29387344
Intestinal perforation 30.51 11.93 97 142261 7989 29424180
Aphasia 30.47 11.93 177 142181 19021 29413148
Cholelithiasis 30.42 11.93 27 142331 18645 29413524
Congenital cardiovascular anomaly 30.01 11.93 16 142342 183 29431986
Acute lymphocytic leukaemia refractory 29.96 11.93 13 142345 90 29432079
Burning sensation 29.84 11.93 20 142338 15918 29416251
Gallbladder oedema 29.71 11.93 16 142342 187 29431982
Hepatosplenic candidiasis 29.71 11.93 16 142342 187 29431982
Delirium 29.70 11.93 94 142264 39303 29392866
Bone marrow disorder 29.67 11.93 37 142321 1515 29430654
Lentigo 29.62 11.93 20 142338 361 29431808
Refractory cancer 29.44 11.93 14 142344 123 29432046
B-cell lymphoma 29.38 11.93 60 142298 3758 29428411
Humoral immune defect 29.37 11.93 12 142346 70 29432099
Skin discolouration 29.31 11.93 19 142339 15390 29416779
Rectal haemorrhage 29.28 11.93 78 142280 34471 29397698
Sleep apnoea syndrome 29.22 11.93 25 142333 17574 29414595
Acute erythroid leukaemia 29.20 11.93 15 142343 158 29432011
Presyncope 29.05 11.93 21 142337 16068 29416101
Acute monocytic leukaemia 29.02 11.93 19 142339 325 29431844
Blindness cortical 28.97 11.93 19 142339 326 29431843
Therapeutic response decreased 28.92 11.93 211 142147 24500 29407669
Hypersomnia 28.83 11.93 8 142350 10746 29421423
Therapy responder 28.64 11.93 15 142343 165 29432004
Aspiration bone marrow abnormal 28.59 11.93 13 142345 102 29432067
Herpes simplex encephalitis 28.58 11.93 18 142340 287 29431882
Organic brain syndrome 28.54 11.93 17 142341 244 29431925
Hypertriglyceridaemia 28.51 11.93 90 142268 7385 29424784
Mass 28.40 11.93 87 142271 7024 29425145
Encephalitis viral 28.35 11.93 31 142327 1101 29431068
Lower respiratory tract infection fungal 28.33 11.93 23 142335 556 29431613
Skin laceration 28.26 11.93 9 142349 11053 29421116
Gait inability 28.26 11.93 28 142330 18347 29413822
B-lymphocyte count decreased 28.10 11.93 22 142336 504 29431665
Molluscum contagiosum 28.07 11.93 17 142341 252 29431917
Human herpesvirus 6 infection reactivation 27.95 11.93 13 142345 108 29432061
Meningitis enteroviral 27.77 11.93 9 142349 23 29432146
Sopor 27.74 11.93 9 142349 10925 29421244
Hypoxia 27.60 11.93 349 142009 47030 29385139
Hypoaesthesia 27.52 11.93 148 142210 53319 29378850
Gastrosplenic fistula 27.49 11.93 9 142349 24 29432145
Enterococcal sepsis 27.43 11.93 35 142323 1467 29430702
Fungal sepsis 27.26 11.93 26 142332 783 29431386
Hypertensive crisis 27.18 11.93 3 142355 7845 29424324
Wound 27.15 11.93 12 142346 12051 29420118
Nervous system disorder 27.14 11.93 127 142231 12547 29419622
Discomfort 27.01 11.93 19 142339 14744 29417425
Steroid diabetes 27.00 11.93 37 142321 1664 29430505
Autoimmune lymphoproliferative syndrome 26.89 11.93 14 142344 152 29432017
Graft versus host disease in lung 26.86 11.93 21 142337 480 29431689
Glomerulonephritis rapidly progressive 26.50 11.93 21 142337 490 29431679
Frequent bowel movements 26.46 11.93 6 142352 9233 29422936
Haematocrit decreased 26.44 11.93 234 142124 28788 29403381
Psychomotor hyperactivity 26.38 11.93 4 142354 8209 29423960
Acute respiratory distress syndrome 26.36 11.93 195 142163 22740 29409429
Glioma 26.31 11.93 17 142341 284 29431885
Splenic candidiasis 26.26 11.93 11 142347 69 29432100
Neuroblastoma recurrent 26.26 11.93 11 142347 69 29432100
T-cell lymphoma stage IV 26.24 11.93 13 142345 126 29432043
Hepatitis viral 26.21 11.93 21 142337 498 29431671
Prescribed overdose 26.18 11.93 5 142353 8678 29423491
Rash pruritic 26.13 11.93 42 142316 22321 29409848
Peripheral motor neuropathy 26.10 11.93 36 142322 1629 29430540
Hyperlipidaemia 26.10 11.93 14 142344 12576 29419593
Lethargy 26.05 11.93 93 142265 37487 29394682
Streptococcal infection 26.04 11.93 63 142295 4425 29427744
Neurofibrosarcoma 26.02 11.93 9 142349 30 29432139
Juvenile melanoma benign 26.00 11.93 11 142347 71 29432098
Ocular hyperaemia 25.99 11.93 6 142352 9121 29423048
Limb discomfort 25.87 11.93 7 142351 9561 29422608
Central nervous system leukaemia 25.74 11.93 16 142342 249 29431920
Coronary artery stenosis 25.72 11.93 5 142353 8568 29423601
Feeling hot 25.71 11.93 22 142336 15466 29416703
Polyomavirus-associated nephropathy 25.69 11.93 53 142305 3343 29428826
Achromobacter infection 25.57 11.93 10 142348 51 29432118
Stenotrophomonas sepsis 25.57 11.93 12 142346 102 29432067
Viral sinusitis 25.49 11.93 11 142347 75 29432094
Cytomegalovirus colitis 25.48 11.93 44 142314 2425 29429744
Eye pain 25.37 11.93 12 142346 11583 29420586
Hepatic infection fungal 25.32 11.93 14 142344 173 29431996
Stenotrophomonas infection 25.24 11.93 36 142322 1681 29430488
Iron deficiency anaemia 25.23 11.93 6 142352 8936 29423233
Melaena 25.21 11.93 72 142286 31104 29401065
Chronic lymphocytic leukaemia refractory 25.13 11.93 11 142347 78 29432091
Enterovesical fistula 25.09 11.93 22 142336 593 29431576
Encephalitis cytomegalovirus 24.97 11.93 20 142338 474 29431695
Hernia 24.81 11.93 5 142353 8353 29423816
Dystonia 24.78 11.93 8 142350 9741 29422428
Haemorrhage 24.76 11.93 122 142236 44950 29387219
Neutropenic infection 24.73 11.93 31 142327 1276 29430893
Panic attack 24.68 11.93 5 142353 8321 29423848
Human metapneumovirus test positive 24.52 11.93 10 142348 58 29432111
Viral load increased 24.48 11.93 39 142319 2010 29430159
Pneumonia viral 24.43 11.93 45 142313 2610 29429559
Pulmonary veno-occlusive disease 24.43 11.93 19 142339 431 29431738
Pneumonia adenoviral 24.36 11.93 13 142345 149 29432020
Hip fracture 24.32 11.93 10 142348 10482 29421687
Metastasis 24.18 11.93 52 142306 3377 29428792
Dyspnoea exertional 24.18 11.93 92 142266 36398 29395771
Primitive neuroectodermal tumour 24.10 11.93 10 142348 61 29432108
West Nile viral infection 24.04 11.93 22 142336 628 29431541
Swelling face 23.99 11.93 38 142320 20312 29411857
Arthritis 23.95 11.93 53 142305 24966 29407203
COVID-19 pneumonia 23.86 11.93 100 142258 9422 29422747
Cerebral aspergillosis 23.83 11.93 31 142327 1325 29430844
Oroantral fistula 23.81 11.93 14 142344 196 29431973
Mood altered 23.77 11.93 5 142353 8106 29424063
Secondary immunodeficiency 23.77 11.93 17 142341 338 29431831
Joint stiffness 23.68 11.93 8 142350 9465 29422704
Metastases to skin 23.64 11.93 17 142341 341 29431828
Haemoglobin abnormal 23.53 11.93 49 142309 3112 29429057
Glycosylated haemoglobin increased 23.49 11.93 8 142350 9418 29422751
Gastrointestinal toxicity 23.35 11.93 39 142319 2092 29430077
Ageusia 23.32 11.93 7 142351 8931 29423238
Ototoxicity 23.28 11.93 33 142325 1532 29430637
Metastases to bone marrow 23.28 11.93 19 142339 463 29431706
Limb injury 23.21 11.93 8 142350 9347 29422822
Carbohydrate antigen 15-3 increased 23.20 11.93 10 142348 68 29432101
Blood culture positive 23.16 11.93 61 142297 4516 29427653
Paresis 23.14 11.93 36 142322 1818 29430351
Salivary gland cancer 22.99 11.93 15 142343 255 29431914
Spermatozoa abnormal 22.84 11.93 9 142349 47 29432122
Transformation to acute myeloid leukaemia 22.78 11.93 22 142336 673 29431496
Chronic myelomonocytic leukaemia 22.75 11.93 20 142338 541 29431628
Metastases to spleen 22.73 11.93 17 142341 363 29431806
Pulmonary alveolar haemorrhage 22.68 11.93 75 142283 6305 29425864
Blood urea increased 22.68 11.93 65 142293 28047 29404122
Plasmablastic lymphoma 22.57 11.93 14 142344 217 29431952
Poisoning 22.40 11.93 10 142348 9983 29422186
Immunosuppression 22.36 11.93 66 142292 5220 29426949
Scedosporium infection 22.32 11.93 23 142335 762 29431407
Akathisia 22.31 11.93 3 142355 6739 29425430
Hepatic candidiasis 22.24 11.93 9 142349 51 29432118
Thrombosis 22.23 11.93 119 142239 42926 29389243
Cellulitis gangrenous 22.23 11.93 13 142345 180 29431989
Eating disorder 22.22 11.93 4 142354 7243 29424926
Adenocarcinoma gastric 22.22 11.93 27 142331 1076 29431093
Pneumonia mycoplasmal 22.20 11.93 20 142338 559 29431610
Therapeutic response unexpected 22.11 11.93 7 142351 8631 29423538
Platelet transfusion 22.01 11.93 27 142331 1087 29431082
Tidal volume decreased 22.01 11.93 8 142350 32 29432137
Pericarditis 21.97 11.93 92 142266 8665 29423504
Mucosal toxicity 21.86 11.93 13 142345 186 29431983
Mucoepidermoid carcinoma 21.85 11.93 7 142351 17 29432152
Pneumaturia 21.82 11.93 8 142350 33 29432136
Adenocarcinoma of colon 21.76 11.93 46 142312 2952 29429217
Muscle rigidity 21.76 11.93 9 142349 9402 29422767
Diabetes mellitus inadequate control 21.70 11.93 16 142342 12118 29420051
Escherichia test positive 21.62 11.93 26 142332 1025 29431144
Device malfunction 21.59 11.93 7 142351 8500 29423669
Rotavirus infection 21.58 11.93 16 142342 337 29431832
Viral test positive 21.56 11.93 13 142345 191 29431978
Capnocytophaga infection 21.55 11.93 9 142349 56 29432113
Chromaturia 21.48 11.93 18 142340 12784 29419385
Splenomegaly 21.44 11.93 123 142235 13156 29419013
Hypofibrinogenaemia 21.38 11.93 31 142327 1470 29430699
Meningeal neoplasm 21.28 11.93 9 142349 58 29432111
Disseminated cytomegaloviral infection 21.27 11.93 13 142345 196 29431973
Product storage error 21.13 11.93 3 142355 6467 29425702
Antithrombin III decreased 21.11 11.93 15 142343 295 29431874
Chronic lymphocytic leukaemia 21.08 11.93 51 142307 3582 29428587
Rhabdomyosarcoma recurrent 21.01 11.93 10 142348 88 29432081
Basophilia 21.00 11.93 6 142352 8 29432161
Granulocyte count decreased 20.92 11.93 20 142338 604 29431565
Chronic kidney disease 20.91 11.93 97 142261 36319 29395850
Haematopoietic stem cell mobilisation 20.85 11.93 12 142346 161 29432008
Accidental exposure to product 20.80 11.93 13 142345 10740 29421429
Abdominal lymphadenopathy 20.80 11.93 21 142337 679 29431490
Underdose 20.77 11.93 16 142342 11853 29420316
Hyperbilirubinaemia 20.73 11.93 133 142225 14801 29417368
Eye disorder 20.68 11.93 6 142352 7828 29424341
Blood cholesterol increased 20.47 11.93 27 142331 15568 29416601
Adenoviral hepatitis 20.44 11.93 13 142345 211 29431958
Movement disorder 20.33 11.93 12 142346 10225 29421944
Glomerulosclerosis 20.30 11.93 21 142337 699 29431470
Alpha haemolytic streptococcal infection 20.28 11.93 23 142335 851 29431318
Intentional product use issue 20.24 11.93 302 142056 42196 29389973
Stevens-Johnson syndrome 20.22 11.93 30 142328 16467 29415702
Mood swings 20.19 11.93 5 142353 7246 29424923
Drug level decreased 20.16 11.93 3 142355 6244 29425925
Dry mouth 20.15 11.93 47 142311 21737 29410432
Vascular access complication 20.08 11.93 13 142345 218 29431951
Disturbance in attention 20.00 11.93 46 142312 21378 29410791
Bordetella infection 19.91 11.93 10 142348 100 29432069
Coronary artery occlusion 19.81 11.93 12 142346 10082 29422087
Haemolytic uraemic syndrome 19.81 11.93 35 142323 1965 29430204
Drug ineffective 19.80 11.93 2016 140342 361154 29071015
Illness 19.80 11.93 4 142354 6670 29425499
Facial paresis 19.73 11.93 41 142317 2600 29429569
Neutrophil count abnormal 19.73 11.93 30 142328 1485 29430684
Exophthalmos 19.66 11.93 18 142340 514 29431655
Left ventricular dysfunction 19.65 11.93 90 142268 8812 29423357
Intestinal atresia 19.64 11.93 9 142349 72 29432097
Clostridium colitis 19.46 11.93 26 142332 1141 29431028
Tendonitis 19.42 11.93 7 142351 7954 29424215
Therapy interrupted 19.42 11.93 8 142350 8378 29423791
Pathogen resistance 19.38 11.93 84 142274 8032 29424137
Infection in an immunocompromised host 19.36 11.93 19 142339 593 29431576
Focal nodular hyperplasia 19.35 11.93 11 142347 144 29432025
Subdural hygroma 19.29 11.93 14 142344 285 29431884
Inflammatory pseudotumour 19.26 11.93 7 142351 28 29432141
Serum ferritin increased 19.26 11.93 65 142293 5523 29426646
Delayed engraftment 19.25 11.93 10 142348 108 29432061
Blood pressure decreased 19.16 11.93 134 142224 45343 29386826
Tooth deposit 19.13 11.93 9 142349 77 29432092
Polyomavirus test positive 18.94 11.93 10 142348 112 29432057
Tooth development disorder 18.89 11.93 6 142352 14 29432155
Hepatic enzyme increased 18.84 11.93 91 142267 33708 29398461
Dementia 18.82 11.93 17 142341 11641 29420528
Lung opacity 18.74 11.93 28 142330 1364 29430805
Periorbital infection 18.71 11.93 10 142348 115 29432054
Post-acute COVID-19 syndrome 18.70 11.93 7 142351 31 29432138
Electrocardiogram abnormal 18.62 11.93 6 142352 7316 29424853
Neoplasm 18.61 11.93 53 142305 4108 29428061
Hyperpyrexia 18.60 11.93 37 142321 2273 29429896
Sinusitis bacterial 18.56 11.93 14 142344 303 29431866
Peripheral T-cell lymphoma unspecified stage IV 18.52 11.93 7 142351 32 29432137
Viral cardiomyopathy 18.52 11.93 7 142351 32 29432137
Actinomycosis 18.46 11.93 15 142343 363 29431806
Ejection fraction decreased 18.44 11.93 136 142222 15842 29416327
Blood loss anaemia 18.40 11.93 6 142352 7260 29424909
Ameloblastoma 18.37 11.93 9 142349 85 29432084
Lymphoplasmacytoid lymphoma/immunocytoma 18.35 11.93 7 142351 33 29432136
Hepatitis D 18.35 11.93 7 142351 33 29432136
Cystitis escherichia 18.34 11.93 11 142347 160 29432009
Central nervous system vasculitis 18.26 11.93 15 142343 369 29431800
Ileus paralytic 18.21 11.93 61 142297 5162 29427007
Fungal oesophagitis 18.13 11.93 14 142344 314 29431855
Enterobacter infection 18.12 11.93 34 142324 2000 29430169
Leukaemic infiltration 18.10 11.93 9 142349 88 29432081
Dysphonia 18.10 11.93 41 142317 19155 29413014
Eczema 18.08 11.93 24 142334 13802 29418367
Inhibin B 18.07 11.93 6 142352 17 29432152
T-cell lymphoma 18.06 11.93 22 142336 879 29431290
Positron emission tomogram abnormal 18.06 11.93 10 142348 124 29432045
Gastric disorder 18.02 11.93 15 142343 10689 29421480
Viraemia 18.02 11.93 24 142334 1050 29431119
Granulomatosis with polyangiitis 17.97 11.93 22 142336 884 29431285
Desmoid tumour 17.92 11.93 9 142349 90 29432079
Disorientation 17.92 11.93 77 142281 29438 29402731
Refractory cytopenia with unilineage dysplasia 17.92 11.93 16 142342 442 29431727
Hepatic amoebiasis 17.90 11.93 8 142350 60 29432109
Pneumatosis intestinalis 17.87 11.93 44 142314 3125 29429044
Inflammatory myofibroblastic tumour 17.85 11.93 10 142348 127 29432042
Metastases to retroperitoneum 17.85 11.93 12 142346 215 29431954
Rubulavirus test positive 17.79 11.93 5 142353 6 29432163
Intussusception 17.74 11.93 17 142341 515 29431654
Arteriosclerosis 17.73 11.93 14 142344 10242 29421927
Haematemesis 17.70 11.93 60 142298 24566 29407603
Medulloblastoma recurrent 17.68 11.93 8 142350 62 29432107
Hepatomegaly 17.54 11.93 90 142268 9227 29422942
Ischaemic cardiomyopathy 17.53 11.93 3 142355 5635 29426534
Blood creatinine increased 17.51 11.93 296 142062 84806 29347363
Peroneal nerve palsy 17.45 11.93 39 142319 2600 29429569
Suspected product quality issue 17.45 11.93 10 142348 133 29432036
Blood pressure diastolic decreased 17.43 11.93 6 142352 7016 29425153
Adenoviral upper respiratory infection 17.37 11.93 4 142354 0 29432169
Blood HIV RNA increased 17.36 11.93 23 142335 1001 29431168
Diaphragm muscle weakness 17.32 11.93 10 142348 135 29432034
Acanthamoeba infection 17.15 11.93 15 142343 403 29431766
Urinary tract infection 17.14 11.93 245 142113 72109 29360060
Metapneumovirus infection 17.12 11.93 18 142340 611 29431558
Hyponatraemia 17.10 11.93 226 142132 67407 29364762
Thirst 17.09 11.93 5 142353 6486 29425683
Mononeuropathy multiplex 17.07 11.93 10 142348 139 29432030
Pneumonia parainfluenzae viral 17.07 11.93 10 142348 139 29432030
Haematoma 17.06 11.93 56 142302 23156 29409013
Hypertension 17.05 11.93 429 141929 116185 29315984
Orthostatic hypotension 17.05 11.93 54 142304 22575 29409594
Neurological decompensation 16.98 11.93 37 142321 2425 29429744
Personality change due to a general medical condition 16.97 11.93 7 142351 42 29432127
Conus medullaris syndrome 16.97 11.93 5 142353 8 29432161
Viral vasculitis 16.85 11.93 8 142350 70 29432099
Central nervous system enteroviral infection 16.83 11.93 7 142351 43 29432126
Respiratory distress 16.82 11.93 232 142126 31874 29400295
Acute lung injury 16.80 11.93 26 142332 1307 29430862
Lip swelling 16.79 11.93 21 142337 12389 29419780
Hepatitis B DNA increased 16.77 11.93 16 142342 482 29431687
Cough 16.75 11.93 473 141885 126254 29305915
Kidney fibrosis 16.74 11.93 33 142325 2014 29430155
Small intestinal perforation 16.73 11.93 29 142329 1603 29430566
Haemolysis 16.61 11.93 72 142286 6884 29425285
Product administration error 16.60 11.93 27 142331 14283 29417886
Sphingomonas paucimobilis infection 16.57 11.93 7 142351 45 29432124
Chylothorax 16.56 11.93 18 142340 635 29431534
Epstein-Barr virus test positive 16.55 11.93 16 142342 490 29431679
Visual impairment 16.55 11.93 80 142278 29628 29402541
Skin mass 16.53 11.93 45 142313 3398 29428771
Tongue fungal infection 16.51 11.93 6 142352 24 29432145
Epistaxis 16.50 11.93 164 142194 51540 29380629
Gastritis erosive 16.49 11.93 3 142355 5390 29426779
Miosis 16.46 11.93 9 142349 8000 29424169
Abdominal pain 16.45 11.93 511 141847 134846 29297323
Tricuspid valve incompetence 16.44 11.93 10 142348 8384 29423785
Ventricular extrasystoles 16.41 11.93 16 142342 10566 29421603
Candida pneumonia 16.38 11.93 13 142345 304 29431865
Infusion site discolouration 16.36 11.93 9 142349 110 29432059
Bronchitis 16.35 11.93 107 142251 36761 29395408
Endocarditis bacterial 16.23 11.93 20 142338 809 29431360
Testicular disorder 16.21 11.93 17 142341 575 29431594
Left ventricular hypertrophy 16.17 11.93 6 142352 6697 29425472
Chronic graft versus host disease in intestine 16.13 11.93 11 142347 202 29431967
Localised infection 16.09 11.93 26 142332 13790 29418379
Amyloidosis 16.02 11.93 32 142326 1972 29430197
Device related thrombosis 15.97 11.93 21 142337 907 29431262
Intestinal obstruction 15.97 11.93 44 142314 19233 29412936
Precursor T-lymphoblastic lymphoma/leukaemia 15.95 11.93 7 142351 50 29432119
Splenic marginal zone lymphoma 15.95 11.93 6 142352 27 29432142
Morphoea 15.85 11.93 10 142348 160 29432009
Hyperthyroidism 15.85 11.93 11 142347 8597 29423572
Cancer fatigue 15.83 11.93 7 142351 51 29432118
Abdominal wall abscess 15.80 11.93 15 142343 449 29431720
Metastases to muscle 15.76 11.93 11 142347 210 29431959
Autonomic neuropathy 15.74 11.93 20 142338 835 29431334
Condition aggravated 15.73 11.93 561 141797 145734 29286435
Pulmonary haemorrhage 15.72 11.93 87 142271 9183 29422986
Kidney transplant rejection 15.72 11.93 7 142351 6998 29425171
Skin exfoliation 15.72 11.93 56 142302 22589 29409580
Salivary hypersecretion 15.71 11.93 8 142350 7401 29424768
Human rhinovirus test positive 15.69 11.93 10 142348 163 29432006
Restless legs syndrome 15.64 11.93 7 142351 6977 29425192
Cytokine storm 15.63 11.93 17 142341 600 29431569
Phlebitis infective 15.62 11.93 9 142349 121 29432048
Marginal zone lymphoma recurrent 15.61 11.93 6 142352 29 29432140
Cerebral salt-wasting syndrome 15.60 11.93 7 142351 53 29432116
Autoimmune pancytopenia 15.60 11.93 8 142350 84 29432085
Cryptococcal fungaemia 15.51 11.93 8 142350 85 29432084
Haemorrhoids 15.48 11.93 20 142338 11637 29420532
Meningitis tuberculous 15.45 11.93 17 142341 608 29431561
Drug clearance decreased 15.44 11.93 26 142332 1404 29430765
Transaminases increased 15.42 11.93 172 142186 22490 29409679
Splenic lesion 15.37 11.93 9 142349 125 29432044
Device occlusion 15.36 11.93 4 142354 5604 29426565
Disorder of orbit 15.35 11.93 8 142350 87 29432082
Adult T-cell lymphoma/leukaemia 15.24 11.93 9 142349 127 29432042
Fluid retention 15.22 11.93 60 142298 23500 29408669
Herpes zoster infection neurological 15.14 11.93 4 142354 3 29432166
Pneumonia aspiration 15.11 11.93 109 142249 36628 29395541
Renal amyloidosis 15.07 11.93 7 142351 58 29432111
CSF protein increased 15.02 11.93 18 142340 707 29431462
Retching 15.01 11.93 5 142353 5968 29426201
Ill-defined disorder 15.00 11.93 102 142256 11576 29420593
Combined immunodeficiency 14.97 11.93 7 142351 59 29432110
Uveitis 14.90 11.93 5 142353 5942 29426227
Dermatitis acneiform 14.88 11.93 4 142354 5487 29426682
Vomiting 14.87 11.93 853 141505 211407 29220762
Gallbladder adenocarcinoma 14.85 11.93 5 142353 15 29432154
Coxsackie viral infection 14.85 11.93 5 142353 15 29432154
Blindness 14.84 11.93 104 142254 11919 29420250
B precursor type acute leukaemia 14.83 11.93 9 142349 134 29432035
Product use issue 14.82 11.93 338 142020 51106 29381063
Hypokinesia 14.80 11.93 9 142349 7545 29424624
Diverticulum 14.73 11.93 6 142352 6326 29425843
Enterocolitis infectious 14.67 11.93 24 142334 1265 29430904
Blister 14.65 11.93 48 142310 19858 29412311
Leukaemia 14.64 11.93 46 142312 3764 29428405
Post-depletion B-cell recovery 14.61 11.93 4 142354 4 29432165
Leukaemia cutis 14.55 11.93 6 142352 36 29432133
Gastric stenosis 14.55 11.93 6 142352 36 29432133
Emotional disorder 14.53 11.93 3 142355 4928 29427241
VIth nerve paralysis 14.51 11.93 18 142340 733 29431436
Streptococcal bacteraemia 14.50 11.93 28 142330 1683 29430486
Evans syndrome 14.47 11.93 11 142347 241 29431928
Palatal ulcer 14.41 11.93 6 142352 37 29432132
Pleural mass 14.39 11.93 7 142351 65 29432104
Lymphocytosis 14.35 11.93 30 142328 1910 29430259
Retinal haemorrhage 14.31 11.93 51 142307 4453 29427716
Cardiogenic shock 14.31 11.93 46 142312 19144 29413025
Cyanosis 14.29 11.93 20 142338 11247 29420922
Prescribed underdose 14.27 11.93 10 142348 7776 29424393
Nasal congestion 14.26 11.93 45 142313 18834 29413335
Bone marrow transplant 14.25 11.93 20 142338 920 29431249
Abdominal neoplasm 14.23 11.93 10 142348 193 29431976
Cardiac murmur 14.23 11.93 7 142351 6606 29425563
Acne 14.23 11.93 14 142344 9206 29422963
Diverticulitis 14.23 11.93 41 142317 17663 29414506
Bladder hypertrophy 14.22 11.93 16 142342 587 29431582
Pulmonary sarcoidosis 14.20 11.93 15 142343 512 29431657
Candida endophthalmitis 14.18 11.93 8 142350 103 29432066
Lung adenocarcinoma 14.18 11.93 46 142312 3829 29428340
Papilloma viral infection 14.08 11.93 14 142344 444 29431725
Drug level increased 14.03 11.93 45 142313 18742 29413427
Fusobacterium infection 14.03 11.93 7 142351 69 29432100
Drug eruption 14.03 11.93 38 142320 16703 29415466
Cutaneous T-cell lymphoma recurrent 14.02 11.93 6 142352 40 29432129
Vascular injury 13.98 11.93 11 142347 254 29431915
Laboratory test abnormal 13.98 11.93 43 142315 18142 29414027
Pleuritic pain 13.98 11.93 38 142320 2867 29429302
Mental impairment 13.97 11.93 14 142344 9127 29423042
Glottis carcinoma 13.95 11.93 5 142353 19 29432150
Follicular mucinosis 13.95 11.93 5 142353 19 29432150
Pulmonary congestion 13.93 11.93 24 142334 12412 29419757
Sepsis syndrome 13.90 11.93 17 142341 682 29431487
Superior sagittal sinus thrombosis 13.90 11.93 11 142347 256 29431913
POEMS syndrome 13.89 11.93 6 142352 41 29432128
Pulmonary oedema 13.87 11.93 135 142223 42600 29389569
Thinking abnormal 13.84 11.93 4 142354 5232 29426937
Rib fracture 13.83 11.93 25 142333 12693 29419476
Haemophilus infection 13.81 11.93 20 142338 947 29431222
Anaphylactic reaction 13.81 11.93 77 142281 27496 29404673
Helicobacter sepsis 13.76 11.93 5 142353 20 29432149
Gliosis 13.74 11.93 9 142349 154 29432015
Pseudomonal bacteraemia 13.73 11.93 20 142338 952 29431217
Rash macular 13.73 11.93 18 142340 10407 29421762
Basal cell carcinoma 13.71 11.93 133 142225 16777 29415392
Gout 13.71 11.93 39 142319 16872 29415297
Increased appetite 13.70 11.93 6 142352 6058 29426111
Pulmonary mucormycosis 13.58 11.93 15 142343 539 29431630
Cerebrosclerosis 13.56 11.93 5 142353 21 29432148
Pneumonia measles 13.56 11.93 5 142353 21 29432148
Brain stem syndrome 13.56 11.93 13 142345 394 29431775
Organising pneumonia 13.42 11.93 54 142304 4994 29427175
Granulocytopenia neonatal 13.38 11.93 5 142353 22 29432147
Multiple sclerosis 13.35 11.93 5 142353 5549 29426620
Atypical teratoid/rhabdoid tumour of CNS 13.35 11.93 4 142354 7 29432162
Viral skin infection 13.31 11.93 6 142352 46 29432123
Hiatus hernia 13.29 11.93 8 142350 6744 29425425
Blast cells present 13.27 11.93 14 142344 477 29431692
Transitional cell carcinoma 13.25 11.93 29 142329 1906 29430263
Tooth hypoplasia 13.24 11.93 8 142350 118 29432051
Musculoskeletal discomfort 13.22 11.93 7 142351 6334 29425835
Malocclusion 13.21 11.93 7 142351 79 29432090
Blood bilirubin increased 13.20 11.93 233 142125 33660 29398509
Peripheral arterial occlusive disease 13.20 11.93 4 142354 5072 29427097
Premature ageing 13.13 11.93 7 142351 80 29432089
Metastases to meninges 13.13 11.93 22 142336 1183 29430986
Hepatitis B e antigen positive 13.10 11.93 6 142352 48 29432121
Refractoriness to platelet transfusion 13.10 11.93 6 142352 48 29432121
Light chain disease 13.07 11.93 8 142350 121 29432048
Meningitis enterococcal 13.06 11.93 7 142351 81 29432088
Bladder spasm 13.04 11.93 18 142340 815 29431354
Disseminated large cell lymphoma 13.02 11.93 3 142355 0 29432169
Klippel-Feil syndrome 13.02 11.93 3 142355 0 29432169
Amniotic fluid volume decreased 13.02 11.93 3 142355 0 29432169
Renal salt-wasting syndrome 13.02 11.93 9 142349 169 29432000
Retrograde portal vein flow 13.02 11.93 3 142355 0 29432169
Hepatosplenic abscess 13.02 11.93 3 142355 0 29432169
Stomatococcal infection 13.01 11.93 8 142350 122 29432047
Urge incontinence 13.01 11.93 14 142344 488 29431681
Ganglioneuroma 13.01 11.93 4 142354 8 29432161
Lymphoplasmacytoid lymphoma/immunocytoma recurrent 13.01 11.93 4 142354 8 29432161
Acinetobacter infection 12.97 11.93 20 142338 1002 29431167
Urinary bladder rupture 12.91 11.93 7 142351 83 29432086
Pneumococcal infection 12.87 11.93 12 142346 351 29431818
Paraesthesia 12.86 11.93 182 142176 53663 29378506
T-cell type acute leukaemia 12.84 11.93 7 142351 84 29432085
Cytomegalovirus enteritis 12.81 11.93 13 142345 423 29431746
Retinitis viral 12.77 11.93 7 142351 85 29432084
Leukaemic infiltration extramedullary 12.77 11.93 7 142351 85 29432084
Viral diarrhoea 12.73 11.93 8 142350 127 29432042
Stomatitis necrotising 12.70 11.93 7 142351 86 29432083
Central nervous system mass 12.70 11.93 7 142351 86 29432083
Choking 12.69 11.93 3 142355 4488 29427681
Blood urine present 12.69 11.93 17 142341 9738 29422431
Peliosis hepatis 12.69 11.93 6 142352 52 29432117
Viral myocarditis 12.68 11.93 8 142350 128 29432041
Fluid imbalance 12.67 11.93 10 142348 232 29431937
Red blood cell schistocytes present 12.67 11.93 10 142348 232 29431937
Necrotising retinitis 12.64 11.93 17 142341 751 29431418
Dizziness postural 12.62 11.93 5 142353 5362 29426807
Gingival hypertrophy 12.61 11.93 26 142332 1639 29430530
Geotrichum infection 12.58 11.93 13 142345 432 29431737
Crying 12.56 11.93 5 142353 5346 29426823
Blood immunoglobulin A decreased 12.56 11.93 10 142348 235 29431934
T-lymphocyte count decreased 12.54 11.93 9 142349 180 29431989
Skin abrasion 12.53 11.93 7 142351 6149 29426020
Cytomegalovirus hepatitis 12.53 11.93 11 142347 297 29431872
Blood iron decreased 12.52 11.93 3 142355 4445 29427724
Body temperature decreased 12.48 11.93 20 142338 10644 29421525
Urinary retention 12.47 11.93 96 142262 31802 29400367
Blood potassium increased 12.47 11.93 33 142325 14618 29417551
Hepatitis B surface antigen positive 12.42 11.93 8 142350 133 29432036
Eye swelling 12.40 11.93 14 142344 8643 29423526
Precursor T-lymphoblastic lymphoma/leukaemia recurrent 12.40 11.93 4 142354 10 29432159
Microgenia 12.40 11.93 4 142354 10 29432159
Ewing's sarcoma recurrent 12.40 11.93 4 142354 10 29432159
Central nervous system haemorrhage 12.40 11.93 6 142352 55 29432114
Chromosome analysis abnormal 12.36 11.93 8 142350 134 29432035
Neurological symptom 12.33 11.93 40 142318 3330 29428839
Cerebral infarction 12.31 11.93 69 142289 24606 29407563
Paraneoplastic pemphigus 12.30 11.93 6 142352 56 29432113
Pneumothorax spontaneous 12.30 11.93 12 142346 372 29431797
Post lumbar puncture syndrome 12.28 11.93 9 142349 186 29431983
Congenital hepatobiliary anomaly 12.26 11.93 5 142353 29 29432140
Angina pectoris 12.26 11.93 81 142277 27769 29404400
Hepatic cancer 12.22 11.93 8 142350 6448 29425721
Microangiopathy 12.21 11.93 17 142341 776 29431393
Gastroenteritis rotavirus 12.20 11.93 9 142349 188 29431981
Respiratory tract congestion 12.17 11.93 5 142353 5244 29426925
Injection site reaction 12.16 11.93 22 142336 11166 29421003
CD4 lymphocytes decreased 12.16 11.93 25 142333 1573 29430596
Hippocampal sclerosis 12.09 11.93 7 142351 95 29432074
Hypouricaemia 12.07 11.93 10 142348 249 29431920
Therapeutic response shortened 12.06 11.93 4 142354 4787 29427382
Intraocular pressure increased 12.05 11.93 4 142354 4785 29427384
Ureaplasma infection 12.04 11.93 9 142349 192 29431977
Tracheal inflammation 12.04 11.93 6 142352 59 29432110
Laryngeal cancer metastatic 12.04 11.93 6 142352 59 29432110
Biopsy lymph gland 12.04 11.93 6 142352 59 29432110
Diffuse large B-cell lymphoma stage III 12.04 11.93 6 142352 59 29432110
Sarcoma metastatic 12.04 11.93 6 142352 59 29432110
Diabetes mellitus 12.02 11.93 128 142230 39703 29392466
Multiple lentigines syndrome 11.99 11.93 5 142353 31 29432138
Neuroborreliosis 11.99 11.93 5 142353 31 29432138
Cryptococcosis 11.97 11.93 28 142330 1924 29430245
Morganella infection 11.97 11.93 13 142345 458 29431711
Incorrect route of product administration 11.96 11.93 21 142337 10780 29421389

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 8044.50 11.10 6540 269233 181117 64041842
Neutropenia 3336.55 11.10 4587 271186 235037 63987922
Product use in unapproved indication 2191.16 11.10 3203 272570 173415 64049544
Cytokine release syndrome 1888.20 11.10 1152 274621 19677 64203282
Bone marrow failure 1869.24 11.10 1587 274186 46365 64176594
Myelosuppression 1704.76 11.10 1135 274638 22695 64200264
Cytomegalovirus infection 1609.46 11.10 1308 274465 35891 64187068
Acute myeloid leukaemia 1600.23 11.10 1153 274620 26310 64196649
Myelodysplastic syndrome 1480.53 11.10 1102 274671 26477 64196482
Acute graft versus host disease 1378.26 11.10 705 275068 8379 64214580
Mucosal inflammation 1321.58 11.10 1480 274293 61104 64161855
Haematotoxicity 1274.14 11.10 754 275019 12142 64210817
Pancytopenia 1212.88 11.10 2187 273586 141122 64081837
Cystitis haemorrhagic 1113.75 11.10 585 275188 7371 64215588
Second primary malignancy 1104.25 11.10 677 275096 11660 64211299
Venoocclusive liver disease 1045.87 11.10 607 275166 9408 64213551
Pyrexia 1039.99 11.10 4926 270847 553718 63669241
Hypogammaglobulinaemia 996.11 11.10 594 275179 9705 64213254
Pneumocystis jirovecii pneumonia 986.15 11.10 870 274903 26764 64196195
Graft versus host disease 985.51 11.10 657 275116 13156 64209803
Hepatitis B 948.30 11.10 521 275252 7224 64215735
Chronic graft versus host disease 946.04 11.10 485 275288 5791 64217168
Off label use 911.02 11.10 5195 270578 627611 63595348
Leukopenia 898.35 11.10 1578 274195 99664 64123295
Thrombocytopenia 898.14 11.10 2537 273236 221264 64001695
Completed suicide 887.95 11.10 14 275759 224400 63998559
Progressive multifocal leukoencephalopathy 849.87 11.10 670 275103 17562 64205397
Diffuse large B-cell lymphoma recurrent 837.00 11.10 360 275413 2786 64220173
Fall 827.87 11.10 374 275399 416452 63806507
Cytopenia 791.89 11.10 601 275172 14870 64208089
Neutrophil count decreased 790.61 11.10 1283 274490 75913 64147046
Acute graft versus host disease in skin 773.40 11.10 437 275336 6418 64216541
Agranulocytosis 750.65 11.10 871 274902 37358 64185601
Disease progression 722.14 11.10 1757 274016 139923 64083036
White blood cell count decreased 710.29 11.10 1867 273906 155970 64066989
Sepsis 703.99 11.10 2375 273398 227966 63994993
Posterior reversible encephalopathy syndrome 689.13 11.10 656 275117 22290 64200669
Pain 682.92 11.10 819 274954 552692 63670267
Neutropenic sepsis 660.59 11.10 645 275128 22627 64200332
Arthralgia 656.38 11.10 557 275216 441703 63781256
Neurotoxicity 642.33 11.10 685 275088 26719 64196240
Febrile bone marrow aplasia 629.13 11.10 461 275312 10794 64212165
Hepatitis B reactivation 621 11.10 337 275436 4552 64218407
Septic shock 612.95 11.10 1377 274396 104060 64118899
Malignant neoplasm progression 596.71 11.10 1420 274353 111451 64111508
Haemophagocytic lymphohistiocytosis 579.98 11.10 530 275243 17079 64205880
Tumour lysis syndrome 574.72 11.10 551 275222 18889 64204070
Venoocclusive disease 566.23 11.10 296 275477 3689 64219270
Product dose omission issue 561.62 11.10 82 275691 194665 64028294
Epstein-Barr virus infection 554.36 11.10 446 275327 12042 64210917
Multiple organ dysfunction syndrome 541.57 11.10 1281 274492 100132 64122827
Cardiotoxicity 514.51 11.10 394 275379 9880 64213079
Joint swelling 508.94 11.10 145 275628 215237 64007722
Cytomegalovirus infection reactivation 490 11.10 306 275467 5450 64217509
Interstitial lung disease 482.76 11.10 1198 274575 96534 64126425
Adenovirus infection 472.02 11.10 326 275447 6929 64216030
Drug abuse 463.52 11.10 25 275748 132349 64090610
Dizziness 459.58 11.10 706 275067 429457 63793502
Pruritus 458.64 11.10 397 275376 312003 63910956
BK virus infection 451.77 11.10 320 275453 7092 64215867
Neoplasm progression 451.03 11.10 704 275069 40260 64182699
Graft versus host disease in skin 449.49 11.10 282 275491 5065 64217894
Disease recurrence 440.34 11.10 606 275167 30904 64192055
Rheumatoid arthritis 436.53 11.10 86 275687 164208 64058751
Platelet count decreased 435.36 11.10 1640 274133 166071 64056888
Bronchopulmonary aspergillosis 420.85 11.10 462 275311 18623 64204336
Acute lymphocytic leukaemia recurrent 420.26 11.10 244 275529 3782 64219177
Post transplant lymphoproliferative disorder 409.13 11.10 334 275439 9210 64213749
Premature menopause 407.51 11.10 133 275640 411 64222548
Overdose 406.55 11.10 92 275681 159474 64063485
Aspergillus infection 395.46 11.10 416 275357 15963 64206996
Peripheral swelling 394.10 11.10 201 275572 208952 64014007
Abdominal discomfort 393.08 11.10 144 275629 182178 64040781
Drug interaction 389.68 11.10 591 275182 361492 63861467
Drug hypersensitivity 384.52 11.10 274 275499 237541 63985418
Anxiety 382.94 11.10 194 275579 202455 64020504
Synovitis 380.32 11.10 9 275764 99081 64123878
Therapy partial responder 380.26 11.10 330 275443 9918 64213041
Nasopharyngitis 377.60 11.10 183 275590 195890 64027069
Fatigue 374.34 11.10 1790 273983 746940 63476019
Diffuse large B-cell lymphoma 373.11 11.10 328 275445 10033 64212926
Respiratory failure 369.55 11.10 1516 274257 159667 64063292
Weight increased 367.54 11.10 229 275544 213119 64009840
Neuropathy peripheral 363.82 11.10 1218 274555 116307 64106652
Lymphopenia 362.35 11.10 496 275277 25161 64197798
Headache 362.29 11.10 1114 274659 528353 63694606
Thrombotic microangiopathy 351.42 11.10 394 275379 16261 64206698
Cytomegalovirus chorioretinitis 351.19 11.10 234 275539 4678 64218281
Cytomegalovirus viraemia 350.89 11.10 323 275450 10505 64212454
Injection site pain 347.72 11.10 36 275737 111372 64111587
Pain in extremity 345.38 11.10 475 275298 302610 63920349
Graft versus host disease in gastrointestinal tract 334.45 11.10 239 275534 5373 64217586
Rash 333.70 11.10 937 274836 457612 63765347
Malaise 331.40 11.10 754 275019 395493 63827466
Arthropathy 330.51 11.10 59 275714 120908 64102051
Immune effector cell-associated neurotoxicity syndrome 321.60 11.10 176 275597 2419 64220540
Ejection fraction decreased 319.66 11.10 496 275277 28211 64194748
Cardiomyopathy 319.27 11.10 464 275309 24892 64198067
Stem cell transplant 316.49 11.10 193 275580 3288 64219671
Swelling 313.87 11.10 146 275627 160072 64062887
Blood pressure increased 311.55 11.10 175 275598 172377 64050582
Aplasia 299.45 11.10 244 275529 6709 64216250
Feeling abnormal 285.40 11.10 107 275666 133495 64089464
Insomnia 278.60 11.10 261 275512 197575 64025384
Human herpesvirus 6 infection 274.59 11.10 197 275576 4457 64218502
Musculoskeletal stiffness 269.40 11.10 95 275678 123111 64099848
Contusion 261.23 11.10 81 275692 113884 64109075
Acute graft versus host disease in intestine 255.78 11.10 171 275602 3438 64219521
Bacteraemia 250.80 11.10 429 275344 26482 64196477
Somnolence 250.58 11.10 301 275472 203344 64019615
Therapeutic product effect decreased 245.34 11.10 93 275680 115258 64107701
Acute promyelocytic leukaemia 240.76 11.10 118 275655 1270 64221689
Pemphigus 238.96 11.10 4 275769 60697 64162262
Contraindicated product administered 235.98 11.10 83 275690 107746 64115213
Wound 235.33 11.10 26 275747 76451 64146508
Muscle spasms 235.06 11.10 157 275616 140866 64082093
Myocardial infarction 234.33 11.10 218 275555 165603 64057356
Lymphadenopathy 232.16 11.10 574 275199 46112 64176847
Metastases to bone 227.39 11.10 353 275420 20082 64202877
Diffuse large B-cell lymphoma refractory 226.75 11.10 106 275667 1018 64221941
Psoriasis 224.15 11.10 23 275750 71680 64151279
Glossodynia 223.99 11.10 13 275760 64683 64158276
Cytogenetic abnormality 223.83 11.10 103 275670 951 64222008
Depression 221.17 11.10 275 275498 183016 64039943
Inappropriate schedule of product administration 219.90 11.10 61 275712 92225 64130734
Ovarian failure 219.47 11.10 84 275689 461 64222498
Urticaria 217.35 11.10 186 275587 147131 64075828
Viral haemorrhagic cystitis 216.86 11.10 116 275657 1519 64221440
Epstein-Barr virus associated lymphoproliferative disorder 216.77 11.10 146 275627 2973 64219986
Intentional product misuse 216.43 11.10 27 275746 72268 64150691
Dyspnoea 215.59 11.10 2001 273772 716673 63506286
Drug resistance 211.11 11.10 465 275308 34637 64188322
Gait disturbance 209.06 11.10 257 275516 171898 64051061
Suicide attempt 209 11.10 28 275745 70979 64151980
Injection site erythema 205.83 11.10 29 275744 70771 64152188
B-cell lymphoma recurrent 204.34 11.10 90 275683 742 64222217
Acquired gene mutation 203.68 11.10 119 275654 1867 64221092
Hypersensitivity 203.06 11.10 329 275444 196123 64026836
Polyneuropathy 201.21 11.10 329 275444 19565 64203394
Secondary immunodeficiency 200.14 11.10 132 275641 2592 64220367
Lymphocyte count decreased 198.78 11.10 497 275276 40202 64182757
JC virus infection 193.33 11.10 140 275633 3215 64219744
Herpes simplex 191.72 11.10 231 275542 10305 64212654
Pleural effusion 188.97 11.10 1052 274721 125507 64097452
Systemic mycosis 188.96 11.10 120 275653 2203 64220756
Hospitalisation 188.20 11.10 45 275728 75162 64147797
Acute lymphocytic leukaemia 187.41 11.10 153 275620 4218 64218741
Hypoglycaemia 186.97 11.10 75 275698 89817 64133142
Stress 185.18 11.10 21 275752 60513 64162446
Toxicity to various agents 183.80 11.10 864 274909 362649 63860310
Systemic lupus erythematosus 183.61 11.10 52 275721 77560 64145399
Mucormycosis 183.55 11.10 190 275583 7151 64215808
Neutropenic colitis 183.18 11.10 154 275619 4427 64218532
Neoplasm recurrence 181.97 11.10 141 275632 3598 64219361
Staphylococcal bacteraemia 178.65 11.10 221 275552 10134 64212825
Chronic lymphocytic leukaemia recurrent 178.12 11.10 73 275700 493 64222466
Loss of personal independence in daily activities 176.18 11.10 46 275727 72408 64150551
Blood glucose increased 176.16 11.10 100 275673 97973 64124986
B-cell type acute leukaemia 175.48 11.10 68 275705 388 64222571
Left ventricular dysfunction 173.66 11.10 282 275491 16672 64206287
Abdominal pain upper 171.77 11.10 303 275470 174727 64048232
Metastases to lymph nodes 171.66 11.10 199 275574 8518 64214441
Chronic graft versus host disease in skin 171.43 11.10 94 275679 1297 64221662
Rhabdomyolysis 169.88 11.10 90 275683 91636 64131323
Anaemia 169.64 11.10 2412 273361 376268 63846691
Mobility decreased 168.37 11.10 78 275695 85762 64137197
Bacterial infection 167.90 11.10 346 275427 24604 64198355
Enterococcal infection 167.69 11.10 249 275524 13617 64209342
Acute graft versus host disease in liver 167.53 11.10 99 275674 1588 64221371
Discomfort 167.35 11.10 68 275705 80810 64142149
Bacterial sepsis 166.95 11.10 182 275591 7275 64215684
Cerebrovascular accident 166.37 11.10 206 275567 137377 64085582
Injury 164.97 11.10 22 275751 55970 64166989
Osteoarthritis 164.29 11.10 35 275738 63301 64159658
Hepatic failure 164.14 11.10 566 275207 54828 64168131
Pneumonia cytomegaloviral 161.53 11.10 140 275633 4199 64218760
Osteonecrosis 160.83 11.10 366 275407 27863 64195096
Pseudomonal sepsis 159.31 11.10 150 275623 5022 64217937
Leukaemia recurrent 158.09 11.10 112 275661 2482 64220477
Hepatic enzyme increased 155.61 11.10 196 275577 129747 64093212
International normalised ratio increased 155.18 11.10 72 275701 79095 64143864
Heart rate decreased 154.46 11.10 25 275748 55042 64167917
Plasma cell myeloma recurrent 153.03 11.10 132 275641 3933 64219026
Klebsiella infection 152.78 11.10 233 275540 13048 64209911
Psoriatic arthropathy 151.98 11.10 8 275765 43273 64179686
Candida infection 151.67 11.10 382 275391 31037 64191922
Arthritis 149.76 11.10 86 275687 83728 64139231
Pseudomonas infection 149.70 11.10 272 275501 17611 64205348
Asthma 149.46 11.10 113 275660 95112 64127847
Bronchitis 146.57 11.10 149 275624 108594 64114365
Confusional state 146.27 11.10 597 275176 260547 63962412
Suicidal ideation 145.94 11.10 51 275722 66491 64156468
Parainfluenzae virus infection 145.03 11.10 137 275636 4606 64218353
Injection site swelling 144.10 11.10 8 275765 41345 64181614
Metastases to liver 142.65 11.10 316 275457 23625 64199334
Bradycardia 140.84 11.10 179 275594 118040 64104919
Injection site bruising 140.72 11.10 3 275770 36370 64186589
Transplant failure 140.40 11.10 122 275651 3672 64219287
Cardiac dysfunction 140.11 11.10 112 275661 2994 64219965
Incorrect dose administered 139.55 11.10 43 275730 60722 64162237
Weight decreased 139.17 11.10 688 275085 285051 63937908
Rhinovirus infection 139.13 11.10 151 275622 6005 64216954
Serotonin syndrome 138.76 11.10 7 275766 39275 64183684
Refractory anaemia with an excess of blasts 138.07 11.10 69 275704 777 64222182
Pneumonia 137.82 11.10 3245 272528 556331 63666628
Cystitis viral 137.53 11.10 63 275710 575 64222384
Peripheral sensory neuropathy 137.13 11.10 204 275569 11174 64211785
Engraftment syndrome 136.58 11.10 75 275698 1038 64221921
Wheezing 136.54 11.10 88 275685 80491 64142468
Injection site pruritus 136.01 11.10 6 275767 37820 64185139
Leukoencephalopathy 135.44 11.10 158 275615 6809 64216150
Fusarium infection 135.03 11.10 84 275689 1485 64221474
Aggression 134.23 11.10 19 275754 46213 64176746
Infection 133.71 11.10 1292 274481 183588 64039371
Congestive cardiomyopathy 132.69 11.10 191 275582 10153 64212806
Metastases to lung 132.67 11.10 236 275537 15028 64207931
Pneumonia fungal 131.99 11.10 176 275597 8701 64214258
Cytomegalovirus test positive 131.98 11.10 135 275638 5009 64217950
Coronary artery disease 131.37 11.10 47 275726 60386 64162573
Irritable bowel syndrome 130.92 11.10 7 275766 37362 64185597
Central nervous system lymphoma 130.71 11.10 89 275684 1846 64221113
Sedation 130.36 11.10 13 275760 41449 64181510
Blood follicle stimulating hormone increased 130.05 11.10 48 275725 234 64222725
Loss of consciousness 129.73 11.10 275 275498 148090 64074869
Plasmacytoma 128.42 11.10 117 275656 3753 64219206
Fibromyalgia 127.39 11.10 6 275767 35725 64187234
Clostridium difficile colitis 127.26 11.10 327 275446 26896 64196063
Mantle cell lymphoma recurrent 126.83 11.10 55 275718 435 64222524
Multiple sclerosis relapse 126.50 11.10 14 275759 41121 64181838
Back pain 126.07 11.10 595 275178 249576 63973383
Drug intolerance 124.93 11.10 400 275373 187592 64035367
Sweat gland tumour 124.82 11.10 55 275718 454 64222505
Hyperkalaemia 124.79 11.10 149 275624 100980 64121979
Myelopathy 123.83 11.10 116 275657 3858 64219101
Hyperhidrosis 123.65 11.10 215 275558 124705 64098254
Hepatotoxicity 123.36 11.10 414 275359 39548 64183411
Disseminated intravascular coagulation 122.78 11.10 360 275413 31988 64190971
Systemic candida 122.69 11.10 132 275641 5197 64217762
Chronic obstructive pulmonary disease 122.57 11.10 76 275697 70972 64151987
Balance disorder 122.48 11.10 107 275666 83819 64139140
Fungal infection 121.33 11.10 372 275401 33879 64189080
Hallucination 121.28 11.10 81 275692 72707 64150252
Cardiac failure 120.48 11.10 973 274800 131400 64091559
Varicella zoster virus infection 120.21 11.10 113 275660 3775 64219184
Staphylococcal infection 120.18 11.10 482 275291 50196 64172763
Staphylococcal sepsis 119.34 11.10 205 275568 12694 64210265
Duodenal ulcer perforation 116.74 11.10 8 275765 34617 64188342
Chest pain 116.71 11.10 565 275208 235415 63987544
Capillary leak syndrome 115.96 11.10 103 275670 3194 64219765
Blood cholesterol increased 115.74 11.10 35 275738 50031 64172928
Gene mutation 115.71 11.10 85 275688 1997 64220962
Infusion related reaction 115.64 11.10 341 275432 164126 64058833
Nephropathy toxic 115.63 11.10 241 275532 17273 64205686
Injection site reaction 114.64 11.10 29 275744 46635 64176324
Pneumonitis 113.86 11.10 472 275301 49893 64173066
Palpitations 113.61 11.10 169 275604 104319 64118640
Blood pressure fluctuation 113.33 11.10 40 275733 51831 64171128
Escherichia bacteraemia 112.57 11.10 127 275646 5276 64217683
Enterococcal bacteraemia 112.30 11.10 90 275683 2415 64220544
Recurrent cancer 112.26 11.10 88 275685 2285 64220674
Blood pressure systolic increased 111.76 11.10 36 275737 49417 64173542
Infection reactivation 110.84 11.10 82 275691 1948 64221011
Refractory cytopenia with multilineage dysplasia 109.96 11.10 42 275731 229 64222730
Condition aggravated 109.45 11.10 1041 274732 371385 63851574
Angioedema 108.22 11.10 65 275708 61756 64161203
Metastases to central nervous system 108.17 11.10 205 275568 13707 64209252
Electrocardiogram QT prolonged 108.03 11.10 108 275665 79340 64143619
Gastrooesophageal reflux disease 106.36 11.10 119 275654 83024 64139935
Urinary tract infection 104.63 11.10 572 275201 231024 63991935
Neck pain 104.52 11.10 67 275706 61466 64161493
Lung infiltration 103.99 11.10 257 275516 20632 64202327
Blood lactate dehydrogenase increased 103.27 11.10 344 275429 32734 64190225
Migraine 102.75 11.10 71 275702 62606 64160353
Therapy non-responder 102.46 11.10 554 275219 65345 64157614
Death 102.33 11.10 1451 274322 481254 63741705
Heart rate increased 102.11 11.10 165 275608 98510 64124449
Hypoxia 101.32 11.10 685 275088 87464 64135495
Acute respiratory distress syndrome 101.01 11.10 381 275392 38554 64184405
Drug withdrawal syndrome 100.53 11.10 9 275764 31282 64191677
Myeloid leukaemia 100.44 11.10 50 275723 558 64222401
Blood stem cell transplant failure 100.39 11.10 48 275725 487 64222472
Chronic myeloid leukaemia 100.39 11.10 96 275677 3278 64219681
Unevaluable event 100.36 11.10 45 275728 50444 64172515
Escherichia sepsis 100.36 11.10 138 275635 7027 64215932
Musculoskeletal pain 100.06 11.10 120 275653 81174 64141785
Emotional distress 99.65 11.10 17 275756 36021 64186938
Accidental overdose 99.29 11.10 13 275760 33544 64189415
Minimal residual disease 98.85 11.10 44 275729 373 64222586
Organising pneumonia 97.37 11.10 154 275619 8901 64214058
Product quality issue 97.29 11.10 8 275765 29791 64193168
Blister 97.04 11.10 122 275651 80845 64142114
Myalgia 96.86 11.10 350 275423 158267 64064692
Product prescribing error 96.72 11.10 17 275756 35252 64187707
Colitis 96.51 11.10 501 275272 58173 64164786
Lactic acidosis 96.19 11.10 73 275700 61337 64161622
Helicobacter infection 95.87 11.10 23 275750 38339 64184620
Breast cancer recurrent 95.46 11.10 83 275690 2500 64220459
Sinusitis 94.50 11.10 314 275459 145614 64077345
Chest discomfort 94.31 11.10 224 275549 115882 64107077
Bone pain 93.90 11.10 428 275345 47144 64175815
Swollen tongue 93.38 11.10 18 275755 34936 64188023
Graft versus host disease in liver 92.68 11.10 66 275707 1475 64221484
Primary hypogonadism 92.34 11.10 33 275740 144 64222815
Nasal congestion 92.06 11.10 72 275701 59586 64163373
Ovarian atrophy 91.82 11.10 28 275745 64 64222895
C-reactive protein abnormal 91.60 11.10 9 275764 29038 64193921
Nephrolithiasis 91.54 11.10 36 275737 43647 64179312
Chronic graft versus host disease in liver 91.50 11.10 46 275727 525 64222434
End stage renal disease 91.09 11.10 162 275611 10313 64212646
Metastasis 91.02 11.10 117 275656 5578 64217381
Computerised tomogram thorax abnormal 90.95 11.10 72 275701 1897 64221062
Injection site haemorrhage 90.19 11.10 3 275770 24275 64198684
Dyspepsia 90.15 11.10 127 275646 80185 64142774
Encephalitis 90.13 11.10 179 275594 12392 64210567
Respiratory syncytial virus infection 90.02 11.10 132 275641 7136 64215823
Mycobacterium chelonae infection 89.93 11.10 74 275699 2063 64220896
Acute myelomonocytic leukaemia 89.89 11.10 37 275736 253 64222706
Lymphoproliferative disorder 89.78 11.10 110 275663 4993 64217966
Sleep disorder 89.72 11.10 74 275699 59635 64163324
Nausea 89.44 11.10 2619 273154 783181 63439778
Agitation 89.35 11.10 150 275623 88217 64134742
Pneumatosis intestinalis 89.24 11.10 111 275662 5118 64217841
Pulmonary alveolar haemorrhage 87.78 11.10 153 275620 9585 64213374
Blood creatine phosphokinase increased 87.46 11.10 73 275700 58485 64164474
Pulmonary haemorrhage 87.26 11.10 181 275592 12928 64210031
Pneumomediastinum 87.21 11.10 83 275690 2817 64220142
Complications of bone marrow transplant 86.89 11.10 46 275727 589 64222370
5q minus syndrome 86.87 11.10 36 275737 251 64222708
Human polyomavirus infection 86.29 11.10 54 275719 965 64221994
Memory impairment 86.12 11.10 146 275627 85536 64137423
Viraemia 85.84 11.10 75 275698 2274 64220685
Respiratory arrest 85.56 11.10 61 275712 52924 64170035
Autoimmune haemolytic anaemia 85.46 11.10 127 275646 6949 64216010
White blood cell count abnormal 84.38 11.10 104 275669 4750 64218209
Anti-Muellerian hormone level decreased 84.32 11.10 27 275746 77 64222882
Nocardiosis 84.26 11.10 103 275670 4664 64218295
Rash pruritic 83.97 11.10 73 275700 57331 64165628
Oedema peripheral 83.07 11.10 542 275231 209775 64013184
Restlessness 83.02 11.10 33 275740 39752 64183207
Intestinal perforation 82.23 11.10 194 275579 15119 64207840
Drug reaction with eosinophilia and systemic symptoms 81.70 11.10 67 275706 54150 64168809
Tremor 81.58 11.10 341 275432 147889 64075070
Osteosarcoma 81.34 11.10 35 275738 271 64222688
Colony stimulating factor therapy 81.10 11.10 41 275732 474 64222485
Biopsy lung abnormal 80.70 11.10 29 275744 129 64222830
Acute myeloid leukaemia recurrent 80.54 11.10 78 275695 2706 64220253
Pulmonary toxicity 80.44 11.10 137 275636 8424 64214535
Oxygen saturation decreased 79.89 11.10 216 275557 106960 64115999
Impaired healing 79.05 11.10 85 275688 60388 64162571
Palmar-plantar erythrodysaesthesia syndrome 78.93 11.10 287 275486 28532 64194427
Drug ineffective for unapproved indication 78.57 11.10 302 275471 30831 64192128
Leukaemia cutis 78.57 11.10 28 275745 121 64222838
Stomatitis 78.20 11.10 764 275009 108841 64114118
Skin toxicity 77.60 11.10 117 275656 6485 64216474
Pneumocystis jirovecii infection 77.60 11.10 71 275702 2290 64220669
Device related infection 77.22 11.10 297 275476 30329 64192630
Escherichia infection 76.97 11.10 188 275585 14980 64207979
Diarrhoea 76.92 11.10 2430 273343 720274 63502685
Klebsiella sepsis 76.63 11.10 74 275699 2558 64220401
Burning sensation 76.56 11.10 60 275713 49604 64173355
Plasma cell leukaemia 76.53 11.10 59 275714 1494 64221465
Joint stiffness 76.43 11.10 18 275755 30386 64192573
Encephalopathy 76.11 11.10 471 275302 58348 64164611
Adverse event 75.71 11.10 37 275736 39452 64183507
Nervousness 75.29 11.10 17 275756 29539 64193420
Labelled drug-drug interaction medication error 74.66 11.10 5 275768 22057 64200902
Engraft failure 74.50 11.10 41 275732 570 64222389
Cardio-respiratory arrest 74.32 11.10 197 275576 98196 64124763
Neutrophil count abnormal 74.29 11.10 76 275697 2820 64220139
Adverse drug reaction 73.86 11.10 52 275721 45412 64177547
Treatment noncompliance 72.95 11.10 48 275725 43434 64179525
Cytomegalovirus colitis 72.91 11.10 87 275686 3841 64219118
Medication error 72.53 11.10 64 275709 49902 64173057
Bone marrow transplant rejection 72.05 11.10 31 275742 240 64222719
Type 2 diabetes mellitus 71.35 11.10 28 275745 33992 64188967
Malignant transformation 71.24 11.10 50 275723 1091 64221868
Gastrointestinal toxicity 70.81 11.10 100 275673 5222 64217737
Bone marrow disorder 70.41 11.10 73 275700 2752 64220207
Myelitis 70.32 11.10 64 275709 2050 64220909
Metabolic acidosis 70.31 11.10 122 275651 70836 64152123
Road traffic accident 70.15 11.10 22 275751 30723 64192236
Microsporidia infection 70.02 11.10 43 275730 742 64222217
Toxoplasmosis 69.82 11.10 68 275705 2376 64220583
Withdrawal syndrome 69.75 11.10 9 275764 23483 64199476
Pseudocirrhosis 69.74 11.10 40 275733 605 64222354
Haematochezia 69.59 11.10 110 275663 66263 64156696
Chemotherapy 69.38 11.10 55 275718 1452 64221507
Human herpesvirus 8 infection 69.29 11.10 48 275725 1025 64221934
Flatulence 69.01 11.10 33 275740 35633 64187326
Drug dependence 68.91 11.10 28 275745 33284 64189675
Smooth muscle cell neoplasm 68.61 11.10 44 275729 822 64222137
Cerebral toxoplasmosis 68.14 11.10 59 275714 1767 64221192
Encephalitis viral 67.58 11.10 66 275707 2314 64220645
Surgery 66.53 11.10 19 275754 28194 64194765
Depressed mood 66.50 11.10 47 275726 40965 64181994
Chronic myelomonocytic leukaemia 66.44 11.10 41 275732 714 64222245
Sopor 66.30 11.10 22 275751 29639 64193320
Traumatic lung injury 66.28 11.10 64 275709 2212 64220747
Peripheral T-cell lymphoma unspecified 66.01 11.10 38 275735 579 64222380
Blood luteinising hormone increased 65.67 11.10 27 275746 184 64222775
Fungaemia 65.64 11.10 81 275692 3704 64219255
Limb injury 65.18 11.10 11 275762 23494 64199465
Breast cancer metastatic 65.09 11.10 113 275660 7056 64215903
Aplastic anaemia 64.84 11.10 167 275606 13753 64209206
Lymphoma 64.68 11.10 167 275606 13774 64209185
Skin laceration 64.33 11.10 13 275760 24404 64198555
Fluid retention 64.20 11.10 97 275676 59509 64163450
Paraparesis 64.07 11.10 77 275696 3425 64219534
Amnesia 64.04 11.10 67 275706 48202 64174757
Peripheral motor neuropathy 63.91 11.10 71 275702 2899 64220060
Therapy responder 63.34 11.10 33 275740 408 64222551
Strongyloidiasis 63.30 11.10 72 275701 3018 64219941
Faeces discoloured 63.18 11.10 16 275757 25713 64197246
Coma 62.02 11.10 181 275592 87434 64135525
Respiratory tract infection fungal 61.63 11.10 45 275728 1047 64221912
Dry mouth 61.59 11.10 102 275671 60316 64162643
Illness 61.43 11.10 10 275763 21928 64201031
Flushing 61.28 11.10 155 275618 78493 64144466
Femur fracture 60.99 11.10 35 275738 34100 64188859
Epstein-Barr viraemia 60.94 11.10 55 275718 1742 64221217
Adenovirus reactivation 60.85 11.10 27 275746 227 64222732
Hip fracture 60.75 11.10 20 275753 27079 64195880
Anaplastic lymphoma kinase gene mutation 60.49 11.10 22 275751 102 64222857
Encephalitis cytomegalovirus 60.34 11.10 43 275730 962 64221997
Guillain-Barre syndrome 59.97 11.10 113 275660 7522 64215437
Candida sepsis 59.95 11.10 60 275713 2168 64220791
Head injury 59.65 11.10 33 275740 32809 64190150
Gastrosplenic fistula 59.62 11.10 20 275753 69 64222890
Obliterative bronchiolitis 59.58 11.10 65 275708 2600 64220359
Abnormal behaviour 59.33 11.10 35 275738 33587 64189372
Epstein-Barr virus infection reactivation 59.00 11.10 45 275728 1121 64221838
Metastases to skin 58.44 11.10 49 275724 1403 64221556
Leukaemia 58.15 11.10 89 275684 4999 64217960
Remission not achieved 57.99 11.10 29 275744 327 64222632
Vision blurred 57.99 11.10 195 275578 90121 64132838
Nightmare 57.83 11.10 10 275763 20983 64201976
Brain abscess 57.77 11.10 80 275693 4101 64218858
Dyskinesia 57.72 11.10 50 275723 39338 64183621
Refractory cytopenia with unilineage dysplasia 57.61 11.10 39 275734 801 64222158
Enterobacter infection 57.61 11.10 75 275698 3621 64219338
Therapy cessation 57.08 11.10 34 275739 32455 64190504
Ileus paralytic 56.96 11.10 117 275656 8298 64214661
Poisoning 56.92 11.10 12 275761 21867 64201092
Fear 56.92 11.10 9 275764 20162 64202797
Frequent bowel movements 56.87 11.10 6 275767 18299 64204660
Graft versus host disease in lung 56.75 11.10 38 275735 766 64222193
Idiopathic pneumonia syndrome 56.58 11.10 33 275740 516 64222443
Abdominal pain 56.57 11.10 967 274806 311408 63911551
Gastric disorder 56.51 11.10 27 275746 29170 64193789
Wrong technique in product usage process 56.28 11.10 121 275652 64853 64158106
Foot fracture 56.28 11.10 6 275767 18151 64204808
Alopecia areata 56.27 11.10 49 275724 1479 64221480
Hypoaesthesia 56.16 11.10 356 275417 138752 64084207
Central nervous system fungal infection 56.14 11.10 30 275743 392 64222567
Focal nodular hyperplasia 56.10 11.10 35 275738 622 64222337
Adenoviral haemorrhagic cystitis 56.08 11.10 32 275741 479 64222480
Dry eye 55.92 11.10 27 275746 28992 64193967
Panic attack 55.53 11.10 11 275762 20942 64202017
Acne 55.44 11.10 15 275758 23066 64199893
Dry skin 55.35 11.10 83 275690 51078 64171881
Alpha haemolytic streptococcal infection 55.00 11.10 51 275722 1674 64221285
Hepatosplenomegaly 54.89 11.10 89 275684 5254 64217705
Erythema 54.79 11.10 523 275250 186547 64036412
Venous thrombosis 54.61 11.10 98 275675 6283 64216676
B-lymphocyte count abnormal 54.59 11.10 18 275755 58 64222901
Vertigo 54.42 11.10 106 275667 58905 64164054
Limb discomfort 54.35 11.10 24 275749 27151 64195808
Device dislocation 54.31 11.10 12 275761 21166 64201793
Hypertension 54.20 11.10 781 274992 258480 63964479
Diffuse alveolar damage 54.13 11.10 68 275705 3167 64219792
Primary amyloidosis 53.78 11.10 20 275753 100 64222859
Syncope 53.59 11.10 424 275349 157211 64065748
Alveolar soft part sarcoma 53.52 11.10 19 275754 81 64222878
Folliculitis 53.51 11.10 31 275742 30046 64192913
Abdominal distension 53.31 11.10 220 275553 95774 64127185
Ascites 53.28 11.10 450 275323 61551 64161408
Asthenia 53.26 11.10 1408 274365 426636 63796323
Adenoviral hepatitis 53.23 11.10 30 275743 438 64222521
Prescribed overdose 53.20 11.10 11 275762 20320 64202639
Meningitis cryptococcal 53.16 11.10 65 275708 2944 64220015
Respiratory depression 53.08 11.10 17 275756 23426 64199533
Clostridium difficile infection 52.84 11.10 299 275474 35864 64187095
Injection site mass 52.79 11.10 6 275767 17264 64205695
Human bocavirus infection 52.78 11.10 32 275741 539 64222420
Diabetic ketoacidosis 52.76 11.10 31 275742 29814 64193145
Hyperpyrexia 52.74 11.10 85 275688 4992 64217967
Foot deformity 52.34 11.10 5 275768 16499 64206460
Blood fibrinogen decreased 52.17 11.10 46 275727 1412 64221547
B-cell lymphoma 52.16 11.10 88 275685 5369 64217590
Blood glucose decreased 51.95 11.10 17 275756 23106 64199853
Splenomegaly 51.86 11.10 182 275591 17779 64205180
Myelitis transverse 51.77 11.10 48 275725 1575 64221384
B-cell aplasia 51.59 11.10 21 275752 139 64222820
Chloroma 51.40 11.10 34 275739 671 64222288
Cholelithiasis 51.02 11.10 72 275701 45434 64177525
Lymphoma transformation 50.97 11.10 23 275750 202 64222757
Metastases to bone marrow 50.61 11.10 33 275740 635 64222324
Crying 50.29 11.10 12 275761 20078 64202881
Device issue 50.27 11.10 17 275756 22631 64200328
Oesophageal candidiasis 50.23 11.10 108 275665 7909 64215050
Enterovirus infection 50.21 11.10 45 275728 1412 64221547
Acute myocardial infarction 50.09 11.10 143 275630 69575 64153384
Multiple sclerosis 50.08 11.10 10 275763 18931 64204028
Ocular hyperaemia 49.97 11.10 17 275756 22547 64200412
Lip swelling 49.87 11.10 38 275735 31869 64191090
Bursitis 49.69 11.10 15 275758 21470 64201489
Gait inability 49.55 11.10 65 275708 42303 64180656
Acute monocytic leukaemia 49.31 11.10 28 275745 415 64222544
Glioma 49.24 11.10 30 275743 510 64222449
Tendonitis 49.06 11.10 13 275760 20269 64202690
Bone marrow transplant 48.87 11.10 42 275731 1245 64221714
Irritability 48.75 11.10 51 275722 36695 64186264
Haematocrit decreased 48.73 11.10 400 275373 54255 64168704
Multifocal micronodular pneumocyte hyperplasia 48.54 11.10 17 275756 69 64222890
Herpes virus infection 48.53 11.10 92 275681 6152 64216807
Transient ischaemic attack 48.45 11.10 71 275702 44111 64178848
Bronchial polyp 48.16 11.10 17 275756 71 64222888
Swelling face 48.14 11.10 114 275659 59052 64163907
Mood altered 47.73 11.10 6 275767 15973 64206986
Enterococcal sepsis 47.55 11.10 56 275717 2438 64220521
Subclavian vein thrombosis 47.54 11.10 54 275719 2260 64220699
Throat irritation 47.35 11.10 42 275731 32669 64190290
Eye swelling 47.28 11.10 18 275755 22263 64200696
Graft versus host disease in eye 47.21 11.10 24 275749 281 64222678
Hypersomnia 47.01 11.10 13 275760 19704 64203255
Polyomavirus-associated nephropathy 46.95 11.10 79 275694 4809 64218150
Alopecia 46.93 11.10 467 275306 165223 64057736
Injection site rash 46.81 11.10 6 275767 15736 64207223
Liver function test abnormal 46.33 11.10 117 275656 59284 64163675
Cardiomyopathy acute 46.29 11.10 22 275751 220 64222739
Pericardial effusion 46.26 11.10 307 275466 38947 64184012
Delirium 46.08 11.10 147 275626 69047 64153912
Aortitis 46.07 11.10 38 275735 1063 64221896
Bone marrow infiltration 46.06 11.10 28 275745 474 64222485
Toxic cardiomyopathy 45.97 11.10 25 275748 339 64222620
Blood culture positive 45.91 11.10 103 275670 7765 64215194
Gastrointestinal haemorrhage 45.85 11.10 354 275419 131958 64091001
Rectal haemorrhage 45.74 11.10 125 275648 61692 64161267
Hip arthroplasty 45.73 11.10 17 275756 21334 64201625
Lower respiratory tract infection fungal 45.48 11.10 34 275739 821 64222138
Autoimmune neutropenia 45.40 11.10 26 275747 392 64222567
Hot flush 45.34 11.10 80 275693 46155 64176804
Pulmonary vascular disorder 45.14 11.10 35 275738 894 64222065
Pulmonary veno-occlusive disease 45.10 11.10 42 275731 1386 64221573
Colitis ulcerative 45.02 11.10 21 275752 23007 64199952
Feeling hot 44.79 11.10 79 275694 45584 64177375
Movement disorder 44.68 11.10 19 275754 21981 64200978
Abortion spontaneous 44.61 11.10 26 275747 25117 64197842
Steroid diabetes 44.55 11.10 56 275717 2610 64220349
Skin discolouration 44.49 11.10 51 275722 35204 64187755
Cerebral aspergillosis 44.47 11.10 45 275728 1648 64221311
Hepatomegaly 44.44 11.10 166 275607 16716 64206243
Herpes zoster 44.37 11.10 526 275247 78661 64144298
Blood pressure diastolic decreased 44.13 11.10 20 275753 22281 64200678
Aphasia 44.10 11.10 313 275460 40593 64182366
Kidney infection 43.98 11.10 11 275762 17827 64205132
Orthostatic hypotension 43.93 11.10 83 275690 46655 64176304
Pneumonia klebsiella 43.88 11.10 69 275704 3968 64218991
Joint range of motion decreased 43.85 11.10 14 275759 19329 64203630
Scedosporium infection 43.75 11.10 39 275734 1215 64221744
Chronic kidney disease 43.70 11.10 116 275657 57803 64165156
Sciatica 43.62 11.10 16 275757 20248 64202711
Procedural pain 43.57 11.10 7 275766 15501 64207458
Sleep apnoea syndrome 43.55 11.10 38 275735 29794 64193165
Device related thrombosis 43.42 11.10 49 275724 2036 64220923
Hernia 43.12 11.10 4 275769 13514 64209445
Meningoencephalitis herpetic 42.99 11.10 45 275728 1716 64221243
Presyncope 42.95 11.10 52 275721 35037 64187922
Therapeutic response unexpected 42.86 11.10 10 275763 16991 64205968
Alveolitis 42.78 11.10 65 275708 3627 64219332
Rheumatoid nodule 42.42 11.10 3 275770 12648 64210311
Acute hepatitis B 42.30 11.10 25 275748 401 64222558
Human herpesvirus 6 encephalitis 42.30 11.10 25 275748 401 64222558
Polyomavirus viraemia 42.26 11.10 37 275736 1125 64221834
Pneumonia adenoviral 42.19 11.10 19 275754 166 64222793
Dystonia 42.15 11.10 14 275759 18851 64204108
Nervous system disorder 42.14 11.10 203 275570 22875 64200084
Myeloproliferative neoplasm 42.12 11.10 33 275740 856 64222103
Hepatitis E 42.12 11.10 52 275721 2379 64220580
Influenza 41.78 11.10 275 275498 106256 64116703
Cryptococcosis 41.54 11.10 55 275718 2700 64220259
Acute kidney injury 41.23 11.10 1538 274235 447702 63775257
Cardiac disorder 41.20 11.10 113 275660 55703 64167256
Extravasation 41.20 11.10 59 275714 3121 64219838
Pulmonary arteriopathy 41.19 11.10 16 275757 92 64222867
Hallucination, visual 41.19 11.10 35 275738 27799 64195160
Salivary gland cancer 41.16 11.10 24 275749 375 64222584
Influenza like illness 41.14 11.10 131 275642 61571 64161388
Acute leukaemia 41.11 11.10 42 275731 1556 64221403
Chronic lymphocytic leukaemia transformation 40.99 11.10 20 275753 213 64222746
Delusion 40.90 11.10 13 275760 18001 64204958
Eczema 40.85 11.10 40 275733 29680 64193279
Glioblastoma multiforme 40.75 11.10 36 275737 1108 64221851
Eye pain 40.72 11.10 45 275728 31580 64191379
Bone marrow necrosis 40.68 11.10 19 275754 182 64222777
Blood potassium increased 40.53 11.10 31 275742 25949 64197010
Adult T-cell lymphoma/leukaemia 40.48 11.10 22 275751 298 64222661
Anger 40.20 11.10 9 275764 15732 64207227
Alveolar proteinosis 39.95 11.10 27 275746 553 64222406
Cutaneous calcification 39.81 11.10 16 275757 102 64222857
Respiratory tract congestion 39.79 11.10 10 275763 16155 64206804
Psychotic disorder 39.47 11.10 54 275719 34524 64188435
Pericarditis 39.43 11.10 136 275637 62380 64160579
Product administration error 39.41 11.10 36 275737 27607 64195352
Maternal exposure during pregnancy 39.40 11.10 244 275529 95640 64127319
Haematopoietic stem cell mobilisation 39.38 11.10 19 275754 197 64222762
Central nervous system leukaemia 39.30 11.10 23 275750 362 64222597
Lethargy 39.30 11.10 168 275605 72426 64150533
Cataract 39.18 11.10 102 275671 51160 64171799
Sinus congestion 39.08 11.10 9 275764 15430 64207529
Madarosis 39.02 11.10 49 275724 2281 64220678
Muscle rigidity 38.98 11.10 13 275760 17460 64205499
Multiple-drug resistance 38.93 11.10 86 275687 6416 64216543
Exposure during pregnancy 38.90 11.10 185 275588 77490 64145469
Klebsiella bacteraemia 38.86 11.10 49 275724 2291 64220668
Localised infection 38.75 11.10 43 275730 30118 64192841
Upper respiratory fungal infection 38.54 11.10 21 275752 286 64222673
Pemphigoid 38.49 11.10 5 275768 12981 64209978
Cardiac arrest 38.48 11.10 447 275326 153617 64069342
Opportunistic infection 38.39 11.10 52 275721 2610 64220349
Iron deficiency anaemia 38.32 11.10 23 275750 21866 64201093
Periarticular thenar erythema with onycholysis 38.10 11.10 11 275762 19 64222940
Middle insomnia 38.07 11.10 5 275768 12872 64210087
Therapy interrupted 38.06 11.10 19 275754 20017 64202942
Blood calcium decreased 37.98 11.10 32 275741 25522 64197437
Extrapyramidal disorder 37.96 11.10 18 275755 19534 64203425
Respirovirus test positive 37.96 11.10 16 275757 117 64222842
Amyloidosis 37.93 11.10 50 275723 2444 64220515
Refractory cancer 37.78 11.10 19 275754 217 64222742
Osteolysis 37.78 11.10 53 275720 2750 64220209
Metastases to pleura 37.67 11.10 36 275737 1228 64221731
Spinal stenosis 37.58 11.10 7 275766 13924 64209035
Pneumonia respiratory syncytial viral 37.52 11.10 38 275735 1393 64221566
Herpes simplex encephalitis 37.51 11.10 27 275746 614 64222345
Red blood cell sedimentation rate increased 37.48 11.10 47 275726 31188 64191771
Nasal cavity cancer 37.41 11.10 17 275756 152 64222807
Cardiac failure congestive 37.40 11.10 367 275406 130213 64092746
Peritonitis pneumococcal 37.39 11.10 11 275762 21 64222938
Glycosylated haemoglobin increased 37.38 11.10 11 275762 16008 64206951
Neutropenic infection 37.26 11.10 44 275729 1921 64221038
Cyst 37.21 11.10 4 275769 12023 64210936
Hallucination, auditory 37.10 11.10 13 275760 16926 64206033
Blast cells present 37.08 11.10 30 275743 816 64222143
Streptococcal bacteraemia 36.97 11.10 55 275718 3012 64219947
Clostridium bacteraemia 36.85 11.10 20 275753 270 64222689
Therapeutic response decreased 36.82 11.10 363 275410 51825 64171134
Retinal haemorrhage 36.80 11.10 91 275682 7307 64215652
Body temperature decreased 36.69 11.10 34 275739 25894 64197065
Dehydration 36.66 11.10 679 275094 216084 64006875
Blood pressure decreased 36.65 11.10 217 275556 85982 64136977
Mucosal toxicity 36.53 11.10 24 275749 468 64222491
Anaphylactic reaction 36.50 11.10 160 275613 68504 64154455
Lymphocytosis 36.48 11.10 60 275713 3584 64219375
Autonomic neuropathy 36.42 11.10 40 275733 1612 64221347
Febrile infection 36.38 11.10 53 275720 2848 64220111
B precursor type acute leukaemia 36.28 11.10 20 275753 279 64222680
Constipation 36.16 11.10 727 275046 228610 63994349
Restless legs syndrome 36.03 11.10 14 275759 17102 64205857
Ventricular hypokinesia 35.97 11.10 93 275680 7676 64215283
Lupus nephritis 35.94 11.10 48 275725 2376 64220583
Metastases to spleen 35.92 11.10 24 275749 482 64222477
Disseminated mucormycosis 35.83 11.10 24 275749 484 64222475
Systemic scleroderma 35.70 11.10 31 275742 932 64222027
Chronic lymphocytic leukaemia refractory 35.44 11.10 15 275758 111 64222848
Hypertriglyceridaemia 35.38 11.10 117 275656 11088 64211871
Heart rate irregular 35.30 11.10 39 275734 27374 64195585
COVID-19 pneumonia 35.21 11.10 152 275621 16352 64206607
Candida pneumonia 35.12 11.10 23 275750 446 64222513
Visual impairment 35.05 11.10 180 275593 73897 64149062
Viral load increased 34.98 11.10 48 275725 2439 64220520
West Nile viral infection 34.97 11.10 30 275743 887 64222072
Cough 34.92 11.10 1004 274769 301144 63921815
Exostosis 34.89 11.10 4 275769 11434 64211525
Thymus hypoplasia 34.78 11.10 24 275749 509 64222450
Rash macular 34.78 11.10 30 275743 23655 64199304
Ankle fracture 34.51 11.10 10 275763 14700 64208259
Anti-neutrophil cytoplasmic antibody positive vasculitis 34.46 11.10 52 275721 2884 64220075
Babesiosis 34.28 11.10 19 275754 268 64222691
Blood creatinine increased 34.28 11.10 393 275380 135389 64087570
Underdose 34.09 11.10 36 275737 25793 64197166
Coronavirus infection 34.08 11.10 74 275699 5456 64217503
Pneumonia bacterial 34.04 11.10 141 275632 14894 64208065
Out of specification test results 34.02 11.10 16 275757 156 64222803
Rotavirus infection 34.01 11.10 25 275748 588 64222371
Gastrointestinal fungal infection 33.97 11.10 21 275752 367 64222592
Choking 33.93 11.10 3 275770 10535 64212424
Haematoma 33.86 11.10 94 275679 46156 64176803
Immunosuppression 33.75 11.10 112 275661 10634 64212325
Hepatic candidiasis 33.72 11.10 13 275760 73 64222886
Granulocyte count decreased 33.67 11.10 34 275739 1242 64221717
T-cell lymphoma 33.65 11.10 33 275740 1163 64221796
Microangiopathic haemolytic anaemia 33.60 11.10 35 275738 1327 64221632
Thyroid disorder 33.48 11.10 5 275768 11687 64211272
Respiratory tract infection 33.47 11.10 274 275499 37133 64185826
Lentigo 33.44 11.10 22 275751 430 64222529
Hyperbilirubinaemia 33.44 11.10 179 275594 21026 64201933
Melaena 33.43 11.10 117 275656 53431 64169528
Acute lymphocytic leukaemia refractory 33.31 11.10 15 275758 131 64222828
Leukaemic infiltration 33.31 11.10 15 275758 131 64222828
Gastrointestinal necrosis 33.31 11.10 69 275704 4923 64218036
Administration site extravasation 33.17 11.10 31 275742 1028 64221931
B-cell lymphoma refractory 33.14 11.10 14 275759 103 64222856
Morphoea 33.09 11.10 21 275752 385 64222574
Granulocytopenia 32.96 11.10 109 275664 10331 64212628
Clostridium colitis 32.93 11.10 47 275726 2478 64220481
Sneezing 32.90 11.10 12 275761 15239 64207720
Muscle spasticity 32.90 11.10 15 275758 16654 64206305
Fungal sepsis 32.89 11.10 38 275735 1620 64221339
Skin mass 32.83 11.10 85 275688 7021 64215938
Dysplasia 32.76 11.10 32 275741 1122 64221837
Metaplasia 32.76 11.10 21 275752 392 64222567
Humoral immune defect 32.69 11.10 14 275759 107 64222852
Hyperlipidaemia 32.66 11.10 30 275743 22946 64200013
Encephalitis enteroviral 32.64 11.10 15 275758 138 64222821
Gallbladder disorder 32.58 11.10 16 275757 17014 64205945
Morganella infection 32.57 11.10 30 275743 976 64221983
Diabetes mellitus inadequate control 32.55 11.10 26 275747 21295 64201664
Epstein-Barr virus associated lymphoma 32.52 11.10 29 275744 904 64222055
Human metapneumovirus test positive 32.36 11.10 15 275758 141 64222818
BK polyomavirus test positive 32.33 11.10 13 275760 83 64222876
Disseminated toxoplasmosis 32.27 11.10 15 275758 142 64222817
Fungal oesophagitis 32.23 11.10 27 275746 772 64222187
Unresponsive to stimuli 32.21 11.10 109 275664 50284 64172675
Blood pressure diastolic abnormal 32.12 11.10 6 275767 11911 64211048
Angina unstable 31.99 11.10 13 275760 15454 64207505
Psychomotor hyperactivity 31.81 11.10 11 275762 14440 64208519
Feeling jittery 31.75 11.10 4 275769 10631 64212328
Lupus vasculitis 31.75 11.10 22 275751 470 64222489
Respiratory distress 31.73 11.10 353 275420 51978 64170981
T-cell type acute leukaemia 31.65 11.10 15 275758 149 64222810
Viral sinusitis 31.65 11.10 16 275757 185 64222774
Pneumonia aspiration 31.57 11.10 138 275635 59133 64163826
Rhabdomyosarcoma recurrent 31.45 11.10 13 275760 90 64222869
Cytomegalovirus enteritis 31.44 11.10 25 275748 663 64222296
Grip strength decreased 31.39 11.10 6 275767 11718 64211241
Product storage error 31.34 11.10 9 275764 13309 64209650
Disseminated cryptococcosis 31.23 11.10 36 275737 1531 64221428
Neuroblastoma 31.22 11.10 15 275758 154 64222805
Impaired work ability 31.14 11.10 13 275760 15206 64207753
Central nervous system enteroviral infection 31.04 11.10 12 275761 68 64222891
Viral test positive 30.89 11.10 20 275753 380 64222579
Blood iron decreased 30.89 11.10 7 275766 12135 64210824
Hepatitis C RNA increased 30.89 11.10 20 275753 380 64222579
Subdural hygroma 30.78 11.10 21 275752 437 64222522
Radiation skin injury 30.72 11.10 33 275740 1297 64221662
Angina pectoris 30.55 11.10 95 275678 44986 64177973
Invasive ductal breast carcinoma 30.54 11.10 67 275706 4975 64217984
Endocarditis bacterial 30.45 11.10 33 275740 1310 64221649
Combined immunodeficiency 30.40 11.10 13 275760 99 64222860
Paraneoplastic pemphigus 30.40 11.10 13 275760 99 64222860
Lower limb fracture 30.35 11.10 10 275763 13535 64209424
Primary cardiac lymphoma 30.32 11.10 9 275764 18 64222941
Pathogen resistance 30.29 11.10 120 275653 12423 64210536
Haemoglobin decreased 30.22 11.10 1068 274705 193995 64028964
Post procedural infection 30.19 11.10 3 275770 9594 64213365
Atelectasis 30.19 11.10 210 275563 27056 64195903
Blindness 30.17 11.10 179 275594 21840 64201119
Prescribed underdose 30.06 11.10 20 275753 17995 64204964
Rubulavirus test positive 30.00 11.10 9 275764 19 64222940
Poor venous access 29.95 11.10 8 275765 12409 64210550
Autoimmune lymphoproliferative syndrome 29.93 11.10 15 275758 170 64222789
Stenotrophomonas infection 29.88 11.10 50 275723 3030 64219929
Dysphonia 29.86 11.10 100 275673 46282 64176677
Coronary artery occlusion 29.85 11.10 11 275762 13880 64209079
Pulmonary mucormycosis 29.82 11.10 26 275747 786 64222173
Blindness cortical 29.79 11.10 26 275747 787 64222172
Clonal evolution 29.74 11.10 16 275757 212 64222747
Haemolytic uraemic syndrome 29.72 11.10 58 275715 3963 64218996
Retching 29.69 11.10 14 275759 15242 64207717
Lymphoid tissue hypoplasia 29.46 11.10 21 275752 470 64222489
Gastric stenosis 29.43 11.10 13 275760 108 64222851
Sinus disorder 29.27 11.10 18 275755 16890 64206069
Blood urea increased 29.25 11.10 94 275679 44059 64178900
Appendiceal abscess 29.19 11.10 17 275756 265 64222694
Triple negative breast cancer 29.16 11.10 12 275761 82 64222877
Disability 29.07 11.10 8 275765 12164 64210795
Metastases to meninges 29.06 11.10 47 275726 2768 64220191
Rotator cuff syndrome 28.83 11.10 8 275765 12099 64210860
Microangiopathy 28.74 11.10 34 275739 1487 64221472
Norovirus test positive 28.71 11.10 20 275753 431 64222528
Neuroblastoma recurrent 28.65 11.10 11 275762 61 64222898
Akathisia 28.56 11.10 7 275766 11503 64211456
Tardive dyskinesia 28.53 11.10 3 275770 9175 64213784
Lumbosacral radiculoplexus neuropathy 28.50 11.10 11 275762 62 64222897
Stenotrophomonas sepsis 28.46 11.10 14 275759 152 64222807
Creatinine renal clearance decreased 28.43 11.10 13 275760 14408 64208551
Acute erythroid leukaemia 28.42 11.10 16 275757 233 64222726
Chronic graft versus host disease in intestine 28.37 11.10 17 275756 280 64222679
Secretion discharge 28.31 11.10 8 275765 11956 64211003
Perineal necrosis 28.25 11.10 13 275760 120 64222839
Delayed engraftment 28.25 11.10 16 275757 236 64222723
Blood loss anaemia 28.21 11.10 12 275761 13880 64209079
Hypertensive crisis 28.18 11.10 22 275751 18226 64204733
Serum ferritin increased 28.16 11.10 90 275683 8378 64214581
Streptococcal infection 28.15 11.10 83 275690 7396 64215563
Ligament sprain 28.13 11.10 6 275767 10846 64212113
Leukoerythroblastosis 28.13 11.10 16 275757 238 64222721
Evans syndrome 28.08 11.10 19 275754 390 64222569
Disease susceptibility 28.01 11.10 16 275757 240 64222719
Primary mediastinal large B-cell lymphoma recurrent 27.93 11.10 11 275762 66 64222893
Dermatitis contact 27.83 11.10 3 275770 8997 64213962
Pseudomonal bacteraemia 27.80 11.10 41 275732 2228 64220731
Trichosporon infection 27.72 11.10 26 275747 866 64222093
Therapeutic response shortened 27.67 11.10 5 275768 10165 64212794
Hyperviscosity syndrome 27.67 11.10 18 275755 345 64222614
Pregnancy 27.63 11.10 29 275744 20836 64202123
Paraplegia 27.57 11.10 60 275713 4430 64218529
Lymphadenopathy mediastinal 27.55 11.10 55 275718 3821 64219138
Glaucoma 27.48 11.10 18 275755 16330 64206629
Adenocarcinoma gastric 27.44 11.10 34 275739 1561 64221398
Acute biphenotypic leukaemia 27.44 11.10 13 275760 129 64222830
Hepatitis viral 27.40 11.10 26 275747 879 64222080
Lennox-Gastaut syndrome 27.35 11.10 15 275758 207 64222752
Red blood cell schistocytes present 27.33 11.10 21 275752 529 64222430
Splenic candidiasis 27.26 11.10 11 275762 71 64222888
Gastritis bacterial 27.25 11.10 17 275756 302 64222657
Abscess bacterial 27.21 11.10 24 275749 737 64222222
Chromaturia 27.15 11.10 34 275739 22577 64200382
Musculoskeletal disorder 27.13 11.10 22 275751 17884 64205075
Ventricular tachycardia 27.10 11.10 67 275706 34198 64188761
T-cell lymphoma stage IV 27.10 11.10 13 275760 133 64222826
Aspiration bone marrow abnormal 27.01 11.10 13 275760 134 64222825
Necrotising gastritis 27 11.10 11 275762 73 64222886
Epstein Barr virus positive mucocutaneous ulcer 26.98 11.10 23 275750 674 64222285
Fusobacterium infection 26.93 11.10 12 275761 102 64222857
Hepatitis B DNA increased 26.90 11.10 22 275751 608 64222351
Sinus bradycardia 26.90 11.10 35 275738 22858 64200101
Chronic lymphocytic leukaemia 26.89 11.10 58 275715 4257 64218702
Haemorrhagic stroke 26.84 11.10 5 275768 9946 64213013
Erythropoiesis abnormal 26.82 11.10 19 275754 421 64222538
Electrocardiogram abnormal 26.81 11.10 12 275761 13469 64209490
Jugular vein thrombosis 26.80 11.10 54 275719 3777 64219182
Tooth fracture 26.75 11.10 5 275768 9922 64213037
Medulloblastoma recurrent 26.73 11.10 12 275761 104 64222855
Cellulitis gangrenous 26.68 11.10 16 275757 264 64222695
Mucosal infection 26.63 11.10 19 275754 426 64222533
Metapneumovirus infection 26.53 11.10 32 275741 1429 64221530
Bone lesion 26.41 11.10 64 275709 5073 64217886
Proteinuria 26.40 11.10 206 275567 27517 64195442
Eye disorder 26.39 11.10 25 275748 18844 64204115
Cerebral venous sinus thrombosis 26.39 11.10 36 275737 1819 64221140
COVID-19 26.32 11.10 408 275365 64732 64158227
Pneumonia pseudomonal 26.20 11.10 62 275711 4841 64218118
Ototoxicity 26.14 11.10 44 275729 2679 64220280
Hiatus hernia 26.13 11.10 28 275745 19929 64203030
Hepatosplenic candidiasis 26.12 11.10 20 275753 501 64222458
Large intestine polyp 26.11 11.10 7 275766 10830 64212129
Thymus enlargement 26.06 11.10 12 275761 111 64222848
Enterobacter bacteraemia 26.03 11.10 21 275752 569 64222390
Osteomyelitis bacterial 26.02 11.10 19 275754 442 64222517
Amenorrhoea 25.99 11.10 74 275699 6465 64216494
Diverticulum 25.86 11.10 12 275761 13186 64209773
Carpal tunnel syndrome 25.84 11.10 18 275755 15810 64207149
Human herpesvirus 6 infection reactivation 25.81 11.10 16 275757 281 64222678
Mood swings 25.80 11.10 22 275751 17446 64205513
Leukaemic infiltration extramedullary 25.74 11.10 13 275760 150 64222809
Metastases to the mediastinum 25.69 11.10 20 275753 514 64222445
Perineal infection 25.68 11.10 17 275756 336 64222623
Glomerulonephritis rapidly progressive 25.62 11.10 30 275743 1298 64221661
Parkinsonism 25.30 11.10 15 275758 14358 64208601
Hydrothorax 25.26 11.10 29 275744 1228 64221731
Epstein-Barr virus test positive 25.25 11.10 26 275747 972 64221987
Enterocolitis infectious 25.25 11.10 41 275732 2423 64220536
Tuberculosis of central nervous system 25.25 11.10 18 275755 403 64222556
Geotrichum infection 25.21 11.10 25 275748 893 64222066
Peripheral sensorimotor neuropathy 25.13 11.10 42 275731 2543 64220416
Disorientation 25.10 11.10 138 275635 55690 64167269
Thinking abnormal 25.09 11.10 9 275764 11547 64211412
Listeria sepsis 25.08 11.10 21 275752 600 64222359
Recall phenomenon 25.08 11.10 26 275747 980 64221979
Eating disorder 25.03 11.10 21 275752 16784 64206175
H1N1 influenza 25.00 11.10 39 275734 2227 64220732
Hilar lymphadenopathy 24.97 11.10 32 275741 1521 64221438
Left ventricular dilatation 24.90 11.10 25 275748 907 64222052
Mucoepidermoid carcinoma 24.85 11.10 10 275763 64 64222895
Metastases to retroperitoneum 24.83 11.10 17 275756 356 64222603
Embolism 24.82 11.10 111 275662 12124 64210835
Central nervous system infection 24.76 11.10 28 275745 1166 64221793
Natural killer-cell leukaemia 24.74 11.10 11 275762 93 64222866
Acute lung injury 24.73 11.10 43 275730 2688 64220271
Listeriosis 24.72 11.10 36 275737 1934 64221025
Laryngitis fungal 24.58 11.10 12 275761 128 64222831
Tinnitus 24.52 11.10 70 275703 34063 64188896
Chromosome analysis abnormal 24.51 11.10 14 275759 210 64222749
Antithrombin III decreased 24.50 11.10 18 275755 423 64222536
Device breakage 24.49 11.10 4 275769 8751 64214208
Large intestinal ulcer perforation 24.47 11.10 10 275763 67 64222892
Metastases to muscle 24.44 11.10 16 275757 310 64222649
Infection in an immunocompromised host 24.42 11.10 26 275747 1011 64221948
VIth nerve paresis 24.41 11.10 12 275761 130 64222829
Poor quality sleep 24.36 11.10 27 275746 18924 64204035
Toxic neuropathy 24.35 11.10 23 275750 773 64222186
Achromobacter infection 24.34 11.10 11 275762 97 64222862
Needle issue 24.29 11.10 5 275768 9267 64213692
Citrobacter bacteraemia 24.28 11.10 7 275766 12 64222947
Hair texture abnormal 24.27 11.10 45 275728 2959 64220000
Rash erythematous 24.25 11.10 116 275657 48517 64174442
Quadriplegia 24.17 11.10 45 275728 2968 64219991
Dementia 24.14 11.10 32 275741 20734 64202225
Oroantral fistula 24.10 11.10 17 275756 374 64222585
Gliosis 24.10 11.10 17 275756 374 64222585
Cholecystectomy 24.03 11.10 3 275770 8029 64214930
Corynebacterium infection 23.99 11.10 25 275748 948 64222011
Pneumaturia 23.98 11.10 8 275765 27 64222932
Capnocytophaga infection 23.98 11.10 10 275763 71 64222888
Mantle cell lymphoma 23.94 11.10 27 275746 1121 64221838
Fracture 23.80 11.10 27 275746 18728 64204231
Meningoencephalitis viral 23.79 11.10 17 275756 382 64222577
Hypoalbuminaemia 23.78 11.10 143 275630 17531 64205428
Disseminated aspergillosis 23.75 11.10 21 275752 647 64222312
IIIrd nerve paralysis 23.67 11.10 26 275747 1048 64221911
Ovarian disorder 23.65 11.10 18 275755 447 64222512
Immune thrombocytopenia 23.63 11.10 127 275646 14939 64208020
Plasma cell myeloma 23.62 11.10 301 275472 45774 64177185
Tooth disorder 23.60 11.10 37 275736 22365 64200594
Intervertebral disc protrusion 23.59 11.10 31 275742 20160 64202799
Scar 23.56 11.10 14 275759 13384 64209575
Musculoskeletal discomfort 23.44 11.10 21 275752 16256 64206703
Epidermal necrosis 23.42 11.10 29 275744 1331 64221628
Ear infection 23.40 11.10 40 275733 23364 64199595
Enteritis 23.34 11.10 108 275665 11969 64210990
Hepatic lesion 23.24 11.10 66 275707 5758 64217201
Nasal abscess 23.20 11.10 12 275761 146 64222813
Thirst 23.18 11.10 16 275757 14121 64208838
Transaminases increased 23.14 11.10 292 275481 44302 64178657
Miosis 23.14 11.10 14 275759 13252 64209707
Product dispensing error 23.08 11.10 10 275763 11440 64211519
Acinetobacter infection 22.99 11.10 39 275734 2390 64220569
Cystitis bacterial 22.90 11.10 17 275756 406 64222553
Palatal ulcer 22.89 11.10 11 275762 113 64222846
Leukaemic lymphoma 22.86 11.10 10 275763 81 64222878
Blood pressure abnormal 22.80 11.10 17 275756 14418 64208541
Miller Fisher syndrome 22.78 11.10 12 275761 152 64222807
Hepatic function abnormal 22.71 11.10 394 275379 63919 64159040
Nephrotic syndrome 22.67 11.10 91 275682 9476 64213483
Cholangiocarcinoma 22.64 11.10 35 275738 1983 64220976
Internal haemorrhage 22.61 11.10 3 275770 7664 64215295
Lymphadenitis 22.59 11.10 50 275723 3735 64219224
Mediastinum neoplasm 22.54 11.10 10 275763 84 64222875
Dyspnoea exertional 22.48 11.10 204 275569 73526 64149433
Hair follicle tumour benign 22.48 11.10 17 275756 418 64222541
Inflammatory myofibroblastic tumour 22.44 11.10 12 275761 157 64222802
Vascular injury 22.44 11.10 25 275748 1024 64221935
Emotional disorder 22.42 11.10 13 275760 12594 64210365
Pharyngeal oedema 22.41 11.10 20 275753 15511 64207448
Prostatic specific antigen increased 22.39 11.10 5 275768 8755 64214204
Laboratory test abnormal 22.38 11.10 43 275730 24020 64198939
Gastroenteritis viral 22.33 11.10 31 275742 19698 64203261
Pneumothorax 22.29 11.10 179 275594 24119 64198840
Body height decreased 22.17 11.10 3 275770 7551 64215408
Facial paresis 22.07 11.10 58 275715 4834 64218125
Oral disorder 22.07 11.10 86 275687 8835 64214124
Skin irritation 22.03 11.10 6 275767 9188 64213771
Herpes zoster cutaneous disseminated 22.03 11.10 16 275757 369 64222590
B-lymphocyte count decreased 22.02 11.10 26 275747 1135 64221824
Myelodysplastic syndrome transformation 22.02 11.10 20 275753 639 64222320
Hair colour changes 21.98 11.10 49 275724 3678 64219281
Blood immunoglobulin A decreased 21.96 11.10 18 275755 499 64222460
Hepatitis B surface antigen positive 21.92 11.10 12 275761 165 64222794
Cytomegalovirus enterocolitis 21.91 11.10 28 275745 1327 64221632
Drug eruption 21.86 11.10 80 275693 36056 64186903
Herpes simplex reactivation 21.76 11.10 14 275759 263 64222696
Pneumonia parainfluenzae viral 21.72 11.10 14 275759 264 64222695
Molluscum contagiosum 21.70 11.10 17 275756 441 64222518
Intussusception 21.70 11.10 23 275750 890 64222069
Hypoproteinaemia 21.70 11.10 46 275727 3336 64219623
Pain in jaw 21.64 11.10 95 275678 40660 64182299
Coeliac disease 21.62 11.10 3 275770 7409 64215550
Ear pain 21.61 11.10 47 275726 25089 64197870
Hyperferritinaemia 21.60 11.10 18 275755 511 64222448
Meningitis enteroviral 21.57 11.10 9 275764 64 64222895
T-cell lymphoma recurrent 21.57 11.10 9 275764 64 64222895
Incorrect route of product administration 21.35 11.10 42 275731 23256 64199703
Haematemesis 21.23 11.10 116 275657 46883 64176076
Anaphylactic shock 21.20 11.10 63 275710 30265 64192694
Optic atrophy 21.19 11.10 31 275742 1672 64221287
Liver function test increased 21.17 11.10 65 275708 30905 64192054
Invasive lobular breast carcinoma 21.13 11.10 18 275755 527 64222432
Retinitis viral 21.13 11.10 10 275763 99 64222860
Thyroid dermatopathy 21.13 11.10 7 275766 23 64222936
Eye irritation 21.04 11.10 22 275751 15834 64207125
Metastases to diaphragm 21.04 11.10 8 275765 43 64222916
Blood glucose abnormal 21.02 11.10 6 275767 8907 64214052
Pleural mass 20.99 11.10 9 275764 69 64222890
Gas gangrene 20.99 11.10 13 275760 228 64222731
Oropharyngeal pain 20.97 11.10 261 275512 88606 64134353
Cardiac amyloidosis 20.95 11.10 28 275745 1387 64221572
Human rhinovirus test positive 20.93 11.10 16 275757 400 64222559
Coma scale abnormal 20.77 11.10 4 275769 7770 64215189
Enteral nutrition 20.74 11.10 8 275765 45 64222914
Skin abrasion 20.72 11.10 12 275761 11633 64211326
Bordetella infection 20.70 11.10 10 275763 104 64222855
Angioimmunoblastic T-cell lymphoma 20.69 11.10 16 275757 407 64222552
Nail pigmentation 20.66 11.10 14 275759 288 64222671
Abdominal neoplasm 20.66 11.10 16 275757 408 64222551
Clear cell renal cell carcinoma 20.64 11.10 35 275738 2144 64220815
Oligohydramnios 20.63 11.10 43 275730 3081 64219878
Rib fracture 20.62 11.10 45 275728 23993 64198966
Diffuse large B-cell lymphoma stage IV 20.54 11.10 17 275756 478 64222481
Stomatococcal infection 20.50 11.10 13 275760 238 64222721
Accidental exposure to product 20.50 11.10 52 275721 26312 64196647
Gastroenteritis norovirus 20.48 11.10 40 275733 2735 64220224
Post procedural haemorrhage 20.48 11.10 14 275759 12417 64210542
Cytokine storm 20.47 11.10 22 275751 865 64222094
Haemolytic anaemia 20.41 11.10 128 275645 15925 64207034
Acute generalised exanthematous pustulosis 20.41 11.10 18 275755 14040 64208919
Cerebral salt-wasting syndrome 20.37 11.10 10 275763 108 64222851
Hepatic infection fungal 20.33 11.10 12 275761 192 64222767
CD4 lymphocytes decreased 20.33 11.10 37 275736 2398 64220561
Superior vena cava syndrome 20.26 11.10 24 275749 1051 64221908
Sputum discoloured 20.26 11.10 28 275745 17828 64205131
Alopecia totalis 20.25 11.10 14 275759 298 64222661
Oesophagitis 20.20 11.10 160 275613 21470 64201489
Lung consolidation 20.18 11.10 76 275697 7682 64215277
Pelvic fracture 20.09 11.10 10 275763 10553 64212406
Karyotype analysis abnormal 20.07 11.10 7 275766 28 64222931
Vomiting 20.04 11.10 2057 273716 549060 63673899
Alternaria infection 19.95 11.10 18 275755 570 64222389
Head discomfort 19.93 11.10 13 275760 11821 64211138
Diverticulitis 19.91 11.10 91 275682 38527 64184432
Marrow hyperplasia 19.90 11.10 27 275746 1357 64221602
Joint effusion 19.86 11.10 17 275756 13456 64209503
Cryptococcal fungaemia 19.80 11.10 11 275762 156 64222803
Lung diffusion test decreased 19.79 11.10 25 275748 1171 64221788
Vocal cord paralysis 19.71 11.10 34 275739 2112 64220847
Meningitis tuberculous 19.63 11.10 24 275749 1087 64221872
Blood urine present 19.60 11.10 30 275743 18310 64204649
Seasonal allergy 19.59 11.10 13 275760 11713 64211246
Immunodeficiency common variable 19.59 11.10 13 275760 258 64222701
Metastases to chest wall 19.59 11.10 15 275758 376 64222583
Campylobacter gastroenteritis 19.54 11.10 24 275749 1092 64221867
Blood pressure systolic abnormal 19.54 11.10 9 275764 9933 64213026
Mesenteric abscess 19.53 11.10 10 275763 119 64222840
Speech disorder 19.52 11.10 124 275649 48317 64174642
Cardiac cirrhosis 19.49 11.10 12 275761 208 64222751
Mydriasis 19.48 11.10 22 275751 15290 64207669
Salivary hypersecretion 19.48 11.10 14 275759 12099 64210860
Carotid intima-media thickness increased 19.47 11.10 9 275764 84 64222875
Precursor T-lymphoblastic lymphoma/leukaemia 19.47 11.10 9 275764 84 64222875
Coronary artery stenosis 19.44 11.10 12 275761 11236 64211723
Neurological decompensation 19.41 11.10 52 275721 4384 64218575
Peritonitis viral 19.40 11.10 8 275765 55 64222904
Actinomycosis 19.38 11.10 22 275751 920 64222039
Ameloblastoma 19.38 11.10 9 275764 85 64222874
Autologous haematopoietic stem cell transplant 19.37 11.10 5 275768 4 64222955
Abnormal loss of weight 19.37 11.10 4 275769 7396 64215563
Herpes zoster meningoencephalitis 19.34 11.10 19 275754 671 64222288
Injection site induration 19.32 11.10 7 275766 8925 64214034
Extramedullary haemopoiesis 19.31 11.10 10 275763 122 64222837
Enterovesical fistula 19.29 11.10 22 275751 925 64222034
Transformation to acute myeloid leukaemia 19.25 11.10 21 275752 840 64222119
Pulmonary fibrosis 19.24 11.10 204 275569 29674 64193285
Unintentional medical device removal 19.24 11.10 68 275705 6666 64216293
Vasculitis 19.23 11.10 138 275635 17957 64205002
Paranoia 19.21 11.10 25 275748 16327 64206632
Dysgeusia 19.18 11.10 120 275653 46927 64176032
Hypertransaminasaemia 19.17 11.10 71 275702 7120 64215839
Peripheral T-cell lymphoma unspecified stage IV 19.15 11.10 7 275766 33 64222926
Marginal zone lymphoma recurrent 19.15 11.10 7 275766 33 64222926
Hemianopia 19.13 11.10 28 275745 1511 64221448
Positron emission tomogram abnormal 19.12 11.10 13 275760 269 64222690
Metastases to peritoneum 19.11 11.10 45 275728 3502 64219457
Hepatic amoebiasis 19.02 11.10 9 275764 89 64222870
Muscle tightness 19.01 11.10 12 275761 11103 64211856
Feeling cold 18.96 11.10 46 275727 23632 64199327
Diffuse large B-cell lymphoma stage II 18.94 11.10 9 275764 90 64222869
Hemiparesis 18.91 11.10 203 275570 29624 64193335
Depressed level of consciousness 18.91 11.10 240 275533 81196 64141763
Drug level decreased 18.89 11.10 13 275760 11490 64211469
Eosinophilia 18.88 11.10 91 275682 37985 64184974
Drug effective for unapproved indication 18.86 11.10 46 275727 3662 64219297
Post-depletion B-cell recovery 18.85 11.10 5 275768 5 64222954
Electrocardiogram ST segment elevation 18.84 11.10 4 275769 7255 64215704
Mycobacterium kansasii infection 18.83 11.10 13 275760 276 64222683
Post-acute COVID-19 syndrome 18.81 11.10 8 275765 60 64222899
Portal hypertension 18.81 11.10 64 275709 6155 64216804
Hypofibrinogenaemia 18.79 11.10 30 275743 1748 64221211
Ewing's sarcoma recurrent 18.77 11.10 6 275767 17 64222942
Bone sarcoma 18.76 11.10 9 275764 92 64222867
Superior sagittal sinus thrombosis 18.75 11.10 22 275751 954 64222005
Granulomatosis with polyangiitis 18.71 11.10 33 275740 2087 64220872
Ocular lymphoma 18.68 11.10 9 275764 93 64222866
Dysstasia 18.67 11.10 45 275728 23170 64199789
Hepatitis D 18.66 11.10 7 275766 36 64222923
Low density lipoprotein increased 18.65 11.10 5 275768 7735 64215224
Angiocentric lymphoma 18.60 11.10 20 275753 787 64222172
Pleural neoplasm 18.58 11.10 12 275761 227 64222732
Cushingoid 18.57 11.10 73 275700 7530 64215429
Disseminated cytomegaloviral infection 18.48 11.10 15 275758 410 64222549
Cryptosporidiosis infection 18.48 11.10 18 275755 629 64222330
Muscle strain 18.45 11.10 6 275767 8188 64214771
Ventricular dysfunction 18.44 11.10 57 275716 5213 64217746
Pharyngitis streptococcal 18.40 11.10 7 275766 8661 64214298
Platelet transfusion 18.38 11.10 30 275743 1781 64221178
Intestinal atresia 18.37 11.10 8 275765 64 64222895
Blood thyroid stimulating hormone increased 18.33 11.10 5 275768 7649 64215310
Metastases to spine 18.32 11.10 45 275728 3598 64219361
Hepatic calcification 18.31 11.10 14 275759 350 64222609
Upper limb fracture 18.22 11.10 22 275751 14844 64208115
Pneumonia viral 18.22 11.10 74 275699 7748 64215211
Disturbance in attention 18.21 11.10 102 275671 40972 64181987
Viral cardiomyopathy 18.20 11.10 7 275766 39 64222920
Glomerular filtration rate decreased 18.18 11.10 35 275738 19537 64203422
CSF protein increased 18.13 11.10 23 275750 1082 64221877
Stevens-Johnson syndrome 18.08 11.10 80 275693 34169 64188790
Kaposi's sarcoma 18.03 11.10 19 275754 730 64222229
Decreased appetite 18.02 11.10 1001 274772 280288 63942671
Sexual dysfunction 18.00 11.10 3 275770 6468 64216491
Haemolysis 17.96 11.10 94 275679 10945 64212014
Paratracheal lymphadenopathy 17.92 11.10 10 275763 143 64222816
Schizophrenia 17.84 11.10 13 275760 11155 64211804
Adenoviral upper respiratory infection 17.84 11.10 4 275769 0 64222959
Lung adenocarcinoma 17.83 11.10 67 275706 6766 64216193
Precursor B-lymphoblastic lymphoma recurrent 17.82 11.10 6 275767 21 64222938
Conus medullaris syndrome 17.82 11.10 6 275767 21 64222938
Platelet count abnormal 17.79 11.10 48 275725 4064 64218895
Herpes simplex viraemia 17.79 11.10 12 275761 245 64222714
Mucosal disorder 17.77 11.10 40 275733 3022 64219937
Pharyngeal inflammation 17.76 11.10 21 275752 918 64222041
Myoclonus 17.69 11.10 52 275721 25066 64197893
Germ cell cancer 17.68 11.10 10 275763 147 64222812
PIK3CA-activated mutation 17.67 11.10 16 275757 509 64222450
Lymphocytic leukaemia 17.65 11.10 11 275762 195 64222764
Non-Hodgkin's lymphoma recurrent 17.61 11.10 6 275767 22 64222937
Jejunal stenosis 17.56 11.10 8 275765 72 64222887
Joint dislocation 17.48 11.10 14 275759 11451 64211508
Osteonecrosis of jaw 17.47 11.10 253 275520 39572 64183387
Myositis 17.47 11.10 125 275648 16252 64206707
Viral sepsis 17.44 11.10 9 275764 109 64222850
Brain stem syndrome 17.40 11.10 19 275754 761 64222198
Metastatic neoplasm 17.39 11.10 50 275723 4392 64218567
Drug level increased 17.38 11.10 81 275692 34115 64188844
Cholecystitis chronic 17.35 11.10 9 275764 9278 64213681
Neurofibrosarcoma 17.32 11.10 11 275762 202 64222757
Ischaemic cardiomyopathy 17.28 11.10 4 275769 6834 64216125
Liver scan abnormal 17.24 11.10 7 275766 46 64222913
Haematocolpos 17.24 11.10 7 275766 46 64222913
Tooth hypoplasia 17.13 11.10 11 275762 206 64222753
Paresis 17.10 11.10 43 275730 3489 64219470
High-grade B-cell lymphoma 17.10 11.10 8 275765 77 64222882
Primary mediastinal large B-cell lymphoma 17.01 11.10 6 275767 25 64222934
Cyanosis 16.99 11.10 44 275729 22111 64200848
Large intestine perforation 16.97 11.10 102 275671 12502 64210457
Cerebral fungal infection 16.97 11.10 13 275760 326 64222633
Right ventricular failure 16.96 11.10 42 275731 21429 64201530
Trichodysplasia spinulosa 16.95 11.10 18 275755 698 64222261
Peripheral vascular disorder 16.92 11.10 5 275768 7256 64215703
Precursor T-lymphoblastic lymphoma/leukaemia recurrent 16.85 11.10 5 275768 10 64222949
Lymphoplasmacytoid lymphoma/immunocytoma recurrent 16.85 11.10 5 275768 10 64222949
Myocardial oedema 16.80 11.10 13 275760 331 64222628
Diaphragm muscle weakness 16.73 11.10 10 275763 164 64222795
Acanthamoeba infection 16.73 11.10 15 275758 471 64222488
Metastases to eye 16.72 11.10 11 275762 215 64222744
T-lymphocyte count decreased 16.70 11.10 15 275758 472 64222487
Vascular access complication 16.68 11.10 22 275751 1076 64221883
Bone density decreased 16.67 11.10 11 275762 9941 64213018
Myelofibrosis 16.66 11.10 32 275741 2161 64220798
Kidney transplant rejection 16.64 11.10 10 275763 9501 64213458
Pneumococcal infection 16.60 11.10 19 275754 802 64222157
Spinal cord disorder 16.59 11.10 27 275746 1599 64221360
Paranasal sinus mucosal hypertrophy 16.58 11.10 8 275765 83 64222876
Chronic cutaneous lupus erythematosus 16.55 11.10 11 275762 219 64222740
Metastases to heart 16.55 11.10 11 275762 219 64222740
Clonal haematopoiesis 16.53 11.10 5 275768 11 64222948
Glottis carcinoma 16.53 11.10 5 275768 11 64222948
Atrioventricular block first degree 16.50 11.10 13 275760 10721 64212238
Pneumonitis chemical 16.37 11.10 13 275760 344 64222615
Peliosis hepatis 16.33 11.10 8 275765 86 64222873
Primary adrenal insufficiency 16.33 11.10 8 275765 86 64222873
Obstructive airways disorder 16.32 11.10 48 275725 23137 64199822
Hydrocephalus 16.26 11.10 70 275703 7521 64215438
Viral skin infection 16.25 11.10 8 275765 87 64222872
Retinal toxicity 16.25 11.10 24 275749 1306 64221653
Li-Fraumeni syndrome 16.23 11.10 5 275768 12 64222947
Intracardiac thrombus 16.22 11.10 44 275729 3737 64219222
Haemorrhage 16.21 11.10 240 275533 79111 64143848
Mycobacterial infection 16.20 11.10 38 275735 2950 64220009
Metastases to uterus 16.18 11.10 7 275766 55 64222904
Tenosynovitis 16.18 11.10 16 275757 11817 64211142
Anal infection 16.17 11.10 8 275765 88 64222871
Tongue fungal infection 16.13 11.10 6 275767 30 64222929
Anorectal cellulitis 16.09 11.10 8 275765 89 64222870
Central nervous system mass 16.09 11.10 8 275765 89 64222870
Drug clearance decreased 16.09 11.10 35 275738 2584 64220375
Inflammatory pseudotumour 16.07 11.10 7 275766 56 64222903
Gout 16.06 11.10 43 275730 21370 64201589
Incorrect product administration duration 16.06 11.10 11 275762 9747 64213212
Transplant dysfunction 16.05 11.10 64 275709 6644 64216315
Groin pain 16.05 11.10 15 275758 11378 64211581
Neurological symptom 16.04 11.10 65 275708 6799 64216160
Arteriosclerosis 15.99 11.10 27 275746 15850 64207109
Respiratory rate increased 15.99 11.10 34 275739 18297 64204662
Device malfunction 15.97 11.10 32 275741 17601 64205358
Primitive neuroectodermal tumour 15.97 11.10 6 275767 31 64222928
Autologous bone marrow transplantation therapy 15.95 11.10 5 275768 13 64222946
VIth nerve paralysis 15.85 11.10 25 275748 1441 64221518
Tracheo-oesophageal fistula 15.84 11.10 15 275758 506 64222453
Sarcoidosis 15.82 11.10 60 275713 6086 64216873
Increased tendency to bruise 15.82 11.10 10 275763 9245 64213714
Hippocampal sclerosis 15.81 11.10 9 275764 134 64222825
Infusion site streaking 15.79 11.10 14 275759 433 64222526
Meningitis enterococcal 15.79 11.10 8 275765 93 64222866
Granulicatella infection 15.76 11.10 7 275766 59 64222900
Cutaneous T-cell lymphoma recurrent 15.76 11.10 7 275766 59 64222900
Rhinorrhoea 15.75 11.10 172 275601 59797 64163162
Necrosis 15.74 11.10 73 275700 8098 64214861
Cytomegalovirus hepatitis 15.70 11.10 16 275757 591 64222368
Blood bilirubin increased 15.69 11.10 339 275434 57214 64165745
Atypical haemolytic uraemic syndrome 15.68 11.10 17 275756 675 64222284
Basophilia 15.67 11.10 6 275767 33 64222926
Non-Hodgkin's lymphoma 15.66 11.10 25 275748 1456 64221503
Chronic hepatitis 15.66 11.10 23 275750 1245 64221714
Mucosal erosion 15.66 11.10 29 275744 1905 64221054
Ill-defined disorder 15.65 11.10 117 275656 43935 64179024
Lymphangiosis carcinomatosa 15.62 11.10 28 275745 1793 64221166
Photosensitivity reaction 15.60 11.10 34 275739 18139 64204820
Fungal test positive 15.60 11.10 20 275753 951 64222008
Tumour necrosis 15.60 11.10 27 275746 1682 64221277
Gastrointestinal inflammation 15.55 11.10 60 275713 6135 64216824
Sinus polyp 15.55 11.10 14 275759 442 64222517
Post lumbar puncture syndrome 15.54 11.10 17 275756 682 64222277
Spinal disorder 15.50 11.10 9 275764 8713 64214246
Executive dysfunction 15.48 11.10 11 275762 245 64222714
B-cell lymphoma stage IV 15.46 11.10 7 275766 62 64222897
Periostitis 15.45 11.10 15 275758 522 64222437
Neuromuscular toxicity 15.45 11.10 10 275763 190 64222769
Splenic necrosis 15.42 11.10 8 275765 98 64222861
Renal amyloidosis 15.41 11.10 9 275764 141 64222818
Viral vasculitis 15.36 11.10 9 275764 142 64222817
Renal salt-wasting syndrome 15.34 11.10 14 275759 450 64222509
Blood pressure diastolic increased 15.33 11.10 14 275759 10738 64212221
Small intestinal perforation 15.30 11.10 34 275739 2546 64220413
Sphingomonas paucimobilis infection 15.28 11.10 8 275765 100 64222859
Xanthogranuloma 15.27 11.10 7 275766 64 64222895
Occult blood positive 15.26 11.10 4 275769 6283 64216676
Walking aid user 15.24 11.10 4 275769 6277 64216682
CD4/CD8 ratio decreased 15.23 11.10 6 275767 36 64222923
Lymphomatoid papulosis 15.23 11.10 12 275761 314 64222645
Erythropenia 15.22 11.10 13 275760 382 64222577
Skin fissures 15.20 11.10 13 275760 10293 64212666
Post procedural complication 15.19 11.10 44 275729 21309 64201650
Macular degeneration 15.13 11.10 3 275770 5707 64217252
Abdominal pain lower 15.10 11.10 60 275713 26409 64196550
Hepatitis B e antigen positive 15.10 11.10 6 275767 37 64222922
POEMS syndrome 15.10 11.10 6 275767 37 64222922
Computerised tomogram thorax 15.09 11.10 9 275764 147 64222812
Vitamin D decreased 15.04 11.10 7 275766 7680 64215279
Radiation necrosis 15.04 11.10 12 275761 320 64222639
Scleroderma renal crisis 15.02 11.10 13 275760 389 64222570
Neuroendocrine carcinoma of the skin 15.01 11.10 20 275753 988 64221971
Septic embolus 15.00 11.10 27 275746 1735 64221224
Primary immunodeficiency syndrome 14.99 11.10 7 275766 67 64222892
Laryngitis 14.98 11.10 15 275758 11016 64211943
Acute pulmonary oedema 14.98 11.10 100 275673 12709 64210250
Arteritis 14.98 11.10 17 275756 711 64222248
Sluggishness 14.98 11.10 3 275770 5667 64217292
Adult T-cell lymphoma/leukaemia recurrent 14.96 11.10 5 275768 17 64222942
Bradyphrenia 14.96 11.10 11 275762 9395 64213564
Mucocutaneous ulceration 14.94 11.10 12 275761 323 64222636
Hereditary motor and sensory neuropathy 14.94 11.10 8 275765 105 64222854
Hepatosplenic T-cell lymphoma 14.92 11.10 18 275755 804 64222155
Transitional cell carcinoma 14.90 11.10 31 275742 2218 64220741
Urinary tract infection bacterial 14.88 11.10 52 275721 5069 64217890
Clostridium test positive 14.86 11.10 45 275728 4070 64218889
Basal ganglion degeneration 14.86 11.10 13 275760 395 64222564
Subacute combined cord degeneration 14.85 11.10 12 275761 326 64222633
T-cell prolymphocytic leukaemia 14.83 11.10 6 275767 39 64222920
Plasmablastic lymphoma 14.83 11.10 13 275760 396 64222563
Sarcoma metastatic 14.82 11.10 7 275766 69 64222890
Hypouricaemia 14.80 11.10 13 275760 397 64222562
Ureaplasma infection 14.79 11.10 17 275756 721 64222238
Gait apraxia 14.74 11.10 5 275768 18 64222941
Increased appetite 14.72 11.10 13 275760 10133 64212826
Exophthalmos 14.70 11.10 25 275748 1535 64221424
Growth retardation 14.69 11.10 25 275748 1536 64221423
Refractoriness to platelet transfusion 14.68 11.10 8 275765 109 64222850
Frustration tolerance decreased 14.67 11.10 4 275769 6121 64216838
Urinary retention 14.62 11.10 137 275636 49064 64173895
Neuroborreliosis 14.61 11.10 8 275765 110 64222849
Transient hypogammaglobulinaemia of infancy 14.58 11.10 6 275767 41 64222918
Eye infection 14.57 11.10 11 275762 9270 64213689
Cerebellar haemangioma 14.56 11.10 7 275766 72 64222887
Aplasia pure red cell 14.51 11.10 64 275709 6950 64216009
Pyloric stenosis 14.50 11.10 13 275760 408 64222551
Intervertebral disc degeneration 14.47 11.10 21 275752 13099 64209860
Metastases to abdominal cavity 14.42 11.10 14 275759 487 64222472
Arterial occlusive disease 14.40 11.10 6 275767 7027 64215932
Jaw operation 14.40 11.10 17 275756 742 64222217
Arthritis infective 14.39 11.10 6 275767 7024 64215935
Ankle brachial index decreased 14.39 11.10 7 275766 74 64222885
Carotid artery stenosis 14.39 11.10 8 275765 7933 64215026
Papilloedema 14.38 11.10 54 275719 5451 64217508
Hepatic necrosis 14.38 11.10 73 275700 8400 64214559
Hepatic vein occlusion 14.37 11.10 9 275764 161 64222798
Central nervous system vasculitis 14.35 11.10 21 275752 1133 64221826
Lupus-like syndrome 14.35 11.10 10 275763 8781 64214178
Brain oedema 14.35 11.10 151 275622 21924 64201035
Cerebrosclerosis 14.33 11.10 5 275768 20 64222939
Cardiac murmur 14.29 11.10 17 275756 11546 64211413
Full blood count abnormal 14.24 11.10 72 275701 29685 64193274
Vitamin B12 deficiency 14.24 11.10 3 275770 5469 64217490
Pulse waveform abnormal 14.23 11.10 7 275766 76 64222883
Lymphoplasmacytoid lymphoma/immunocytoma 14.22 11.10 6 275767 44 64222915
Bacterial translocation 14.19 11.10 13 275760 420 64222539
Throat tightness 14.19 11.10 51 275722 23109 64199850
Necrotising retinitis 14.18 11.10 20 275753 1043 64221916
Prostatic abscess 14.15 11.10 12 275761 349 64222610
Pneumonia measles 14.14 11.10 5 275768 21 64222938
Glomerulosclerosis 14.14 11.10 19 275754 946 64222013
Helicobacter sepsis 14.14 11.10 5 275768 21 64222938
Gastric pneumatosis 14.14 11.10 5 275768 21 64222938
Erectile dysfunction 14.13 11.10 20 275753 12607 64210352
Gastric perforation 14.13 11.10 40 275733 3483 64219476
Cranial nerve disorder 14.10 11.10 18 275755 852 64222107
Blast cell count increased 14.09 11.10 22 275751 1257 64221702
Weight fluctuation 14.08 11.10 9 275764 8273 64214686
Burkitt's lymphoma 14.06 11.10 8 275765 119 64222840
Disorder of orbit 14.06 11.10 8 275765 119 64222840
Aphonia 14.05 11.10 10 275763 8687 64214272
Mediastinal mass 14.05 11.10 14 275759 503 64222456
Blood potassium decreased 14.02 11.10 108 275665 40291 64182668
Follicular mucinosis 13.96 11.10 5 275768 22 64222937
Drug level above therapeutic 13.95 11.10 6 275767 6895 64216064
Blood pressure inadequately controlled 13.91 11.10 3 275770 5381 64217578
Tooth development disorder 13.88 11.10 6 275767 47 64222912
Intracranial pressure increased 13.87 11.10 63 275710 6926 64216033
Vasogenic cerebral oedema 13.87 11.10 19 275754 964 64221995
Ovarian cyst 13.83 11.10 16 275757 11002 64211957
Carbohydrate antigen 15-3 increased 13.81 11.10 19 275754 968 64221991
Enterovirus test positive 13.79 11.10 10 275763 230 64222729
Atypical teratoid/rhabdoid tumour of CNS 13.78 11.10 5 275768 23 64222936
Splenic marginal zone lymphoma 13.78 11.10 5 275768 23 64222936
Mucocutaneous haemorrhage 13.77 11.10 9 275764 174 64222785
Accident 13.76 11.10 6 275767 6840 64216119
Personality change 13.73 11.10 10 275763 8583 64214376
Faeces soft 13.70 11.10 4 275769 5851 64217108
Skin burning sensation 13.69 11.10 15 275758 10568 64212391
Cerebellar stroke 13.69 11.10 13 275760 440 64222519
Cystoid macular oedema 13.62 11.10 26 275747 1748 64221211
Streptococcal sepsis 13.61 11.10 31 275742 2361 64220598
Hepatitis 13.58 11.10 272 275501 45310 64177649
Intestinal obstruction 13.56 11.10 95 275678 36191 64186768
Dizziness postural 13.55 11.10 13 275760 9739 64213220
Lupus myocarditis 13.55 11.10 7 275766 85 64222874
Epstein-Barr virus antigen positive 13.55 11.10 7 275766 85 64222874
Pulmonary thrombosis 13.50 11.10 15 275758 10503 64212456
Anogenital warts 13.48 11.10 17 275756 795 64222164
Systolic dysfunction 13.48 11.10 37 275736 3165 64219794
Chromosomal deletion 13.48 11.10 7 275766 86 64222873
Premature ageing 13.48 11.10 7 275766 86 64222873
Ageusia 13.45 11.10 24 275749 13789 64209170
Malassezia infection 13.44 11.10 5 275768 25 64222934
Arrhythmia 13.44 11.10 153 275620 52791 64170168
Abdominal abscess 13.40 11.10 58 275715 6246 64216713
Cytokine abnormal 13.38 11.10 3 275770 0 64222959
Breast angiosarcoma 13.38 11.10 3 275770 0 64222959
Hepatosplenic abscess 13.38 11.10 3 275770 0 64222959
Cutaneous T-cell lymphoma refractory 13.38 11.10 3 275770 0 64222959
Urinary bladder atrophy 13.38 11.10 3 275770 0 64222959
Hormone receptor positive breast cancer 13.36 11.10 11 275762 307 64222652
Viral infection 13.34 11.10 223 275550 35917 64187042
Soft tissue infection 13.33 11.10 37 275736 3186 64219773
Blood triglycerides increased 13.33 11.10 39 275734 18827 64204132
Bronchiolitis 13.32 11.10 40 275733 3601 64219358
Opsoclonus myoclonus 13.29 11.10 9 275764 185 64222774
Infusion site vesicles 13.27 11.10 12 275761 381 64222578
Pulmonary hypoplasia 13.27 11.10 6 275767 53 64222906
Systemic inflammatory response syndrome 13.26 11.10 82 275691 10153 64212806
Pleural disorder 13.24 11.10 16 275757 716 64222243
Dental caries 13.22 11.10 16 275757 10784 64212175
Cardiac valve disease 13.21 11.10 3 275770 5192 64217767
Arachnoid cyst 13.18 11.10 11 275762 313 64222646
Polyp 13.18 11.10 6 275767 6667 64216292
Neutrophil percentage decreased 13.17 11.10 16 275757 720 64222239
Metastases to stomach 13.15 11.10 10 275763 248 64222711
Cold sweat 13.15 11.10 32 275741 16423 64206536
Gastrointestinal motility disorder 13.15 11.10 3 275770 5176 64217783
Urinary bladder rupture 13.13 11.10 7 275766 91 64222868
Extrasystoles 13.13 11.10 6 275767 6652 64216307
Gastritis erosive 13.09 11.10 13 275760 9582 64213377
Pollakiuria 13.07 11.10 80 275693 31450 64191509
Chronic hepatitis B 13.01 11.10 10 275763 252 64222707
Central nervous system neoplasm 13.00 11.10 7 275766 93 64222866
Human herpesvirus 7 infection 13.00 11.10 7 275766 93 64222866
Hypomania 12.98 11.10 4 275769 5650 64217309
Intentional dose omission 12.97 11.10 4 275769 5648 64217311
Neoplasm 12.94 11.10 62 275711 6969 64215990
Acute interstitial pneumonitis 12.94 11.10 19 275754 1028 64221931
Gastroenteritis cryptosporidial 12.91 11.10 10 275763 255 64222704
Corynebacterium sepsis 12.89 11.10 6 275767 57 64222902
Aortic arteriosclerosis 12.88 11.10 8 275765 7468 64215491
Stomatitis necrotising 12.88 11.10 9 275764 195 64222764
Microgenia 12.87 11.10 4 275769 10 64222949
Roseolovirus test positive 12.84 11.10 9 275764 196 64222763
Gingival hypertrophy 12.84 11.10 33 275740 2714 64220245
Intraocular pressure increased 12.83 11.10 10 275763 8292 64214667
Retroperitoneal lymphadenopathy 12.80 11.10 18 275755 936 64222023
Generalised oedema 12.79 11.10 141 275632 20712 64202247
Mitral valve incompetence 12.73 11.10 166 275607 25372 64197587
Peripheral arterial occlusive disease 12.72 11.10 7 275766 6980 64215979
CSF test abnormal 12.71 11.10 13 275760 482 64222477
Respiratory acidosis 12.71 11.10 14 275759 9841 64213118
Blood chloride decreased 12.69 11.10 8 275765 7408 64215551
Desmoid tumour 12.69 11.10 8 275765 145 64222814
Renal pain 12.68 11.10 7 275766 6967 64215992
Endocardial fibrosis 12.62 11.10 6 275767 60 64222899
Sleep disorder due to a general medical condition 12.62 11.10 10 275763 8224 64214735
Paraesthesia oral 12.62 11.10 23 275750 13108 64209851
Suspected product quality issue 12.61 11.10 10 275763 264 64222695
Endocrine ophthalmopathy 12.61 11.10 12 275761 407 64222552
Metastatic lymphoma 12.60 11.10 9 275764 202 64222757
Haemoglobin abnormal 12.58 11.10 55 275718 5949 64217010
Dysgraphia 12.57 11.10 38 275735 3433 64219526
Arteriosclerosis coronary artery 12.57 11.10 30 275743 15499 64207460
Leukonychia 12.56 11.10 5 275768 31 64222928
Median nerve injury 12.56 11.10 5 275768 31 64222928
Tissue infiltration 12.46 11.10 14 275759 579 64222380
Perineal ulceration 12.45 11.10 6 275767 62 64222897
Tongue oedema 12.44 11.10 5 275768 5985 64216974
Mantle cell lymphoma refractory 12.43 11.10 7 275766 102 64222857
Adenocarcinoma 12.43 11.10 37 275736 3314 64219645
Duodenal ulcer 12.40 11.10 27 275746 14408 64208551
Light chain analysis increased 12.38 11.10 21 275752 1287 64221672
Dermatitis allergic 12.38 11.10 29 275744 15080 64207879
JC virus CSF test positive 12.36 11.10 8 275765 152 64222807
Mucosal haemorrhage 12.36 11.10 29 275744 2252 64220707
Fungal skin infection 12.35 11.10 49 275724 5076 64217883
Meningeal neoplasm 12.34 11.10 4 275769 12 64222947
Chylothorax 12.32 11.10 14 275759 586 64222373
Splenic infection fungal 12.31 11.10 7 275766 104 64222855
Complication associated with device 12.31 11.10 29 275744 15051 64207908
Lower respiratory tract infection 12.31 11.10 309 275464 94305 64128654
Abdominal compartment syndrome 12.31 11.10 22 275751 1406 64221553
Blood immunoglobulin G decreased 12.30 11.10 32 275741 2651 64220308
Central nervous system necrosis 12.30 11.10 10 275763 274 64222685
Allogenic bone marrow transplantation therapy 12.30 11.10 5 275768 33 64222926
Blood alkaline phosphatase increased 12.28 11.10 168 275605 56111 64166848
Synovial cyst 12.27 11.10 9 275764 7698 64215261
Merycism 12.27 11.10 9 275764 211 64222748
Meningitis 12.25 11.10 69 275704 8260 64214699
Transplant rejection 12.25 11.10 121 275652 17280 64205679
Candida endophthalmitis 12.22 11.10 8 275765 155 64222804
Adverse reaction 12.21 11.10 9 275764 7678 64215281
Infective thrombosis 12.21 11.10 6 275767 65 64222894
Pathological fracture 12.21 11.10 73 275700 8932 64214027
Hypercholesterolaemia 12.20 11.10 30 275743 15343 64207616
Micrococcus infection 12.20 11.10 7 275766 106 64222853
Vaginal infection 12.19 11.10 3 275770 4917 64218042
Areflexia 12.17 11.10 48 275725 4959 64218000
Rhinitis allergic 12.15 11.10 10 275763 8068 64214891
Pleocytosis 12.14 11.10 19 275754 1088 64221871
Productive cough 12.14 11.10 230 275543 72973 64149986
Mass 12.14 11.10 109 275664 15167 64207792
Mental impairment 12.12 11.10 33 275740 16310 64206649
Herpes sepsis 12.10 11.10 4 275769 13 64222946
Squamous cell carcinoma 12.09 11.10 101 275672 13768 64209191
Hypoglossal nerve paresis 12.08 11.10 7 275766 108 64222851
Oral candidiasis 12.05 11.10 152 275621 23060 64199899
Lower gastrointestinal haemorrhage 12.03 11.10 26 275747 13913 64209046
Monocyte count decreased 12.01 11.10 33 275740 2824 64220135
Peripheral coldness 12.01 11.10 25 275748 13559 64209400
Hypothermia 11.98 11.10 44 275729 19812 64203147
Ulcer 11.95 11.10 54 275719 22936 64200023
Haptoglobin decreased 11.95 11.10 20 275753 1212 64221747
Thrombotic thrombocytopenic purpura 11.92 11.10 54 275719 5930 64217029
Lung neoplasm 11.90 11.10 56 275717 6249 64216710
Abdominal lymphadenopathy 11.90 11.10 19 275754 1107 64221852
Tidal volume decreased 11.90 11.10 6 275767 69 64222890
Hepatic infarction 11.89 11.10 16 275757 798 64222161
Hypothyroidism 11.87 11.10 113 275660 40344 64182615
Bronchospasm 11.84 11.10 50 275723 21632 64201327
Pulmonary sarcoidosis 11.84 11.10 19 275754 1112 64221847
Nasal septum disorder 11.81 11.10 7 275766 113 64222846
Pyomyositis 11.78 11.10 13 275760 527 64222432
Flank pain 11.78 11.10 33 275740 16156 64206803
Night sweats 11.76 11.10 98 275675 35948 64187011
Tongue disorder 11.75 11.10 21 275752 12059 64210900
Varicella 11.75 11.10 31 275742 2590 64220369
Respiratory tract infection bacterial 11.75 11.10 16 275757 807 64222152
Tooth deposit 11.74 11.10 9 275764 226 64222733
Blood HIV RNA increased 11.70 11.10 22 275751 1462 64221497
Cerebellar tumour 11.67 11.10 6 275767 72 64222887
Klebsiella test positive 11.67 11.10 21 275752 1349 64221610
Metastases to tonsils 11.67 11.10 4 275769 15 64222944
Ureteric dilatation 11.66 11.10 8 275765 168 64222791
Listeria encephalitis 11.56 11.10 10 275763 299 64222660
Acute polyneuropathy 11.54 11.10 11 275762 374 64222585
Facial paralysis 11.52 11.10 128 275645 18838 64204121
Skin warm 11.51 11.10 5 275768 5712 64217247
Hodgkin's disease 11.48 11.10 16 275757 825 64222134
Bone marrow tumour cell infiltration 11.48 11.10 5 275768 40 64222919
Noctiphobia 11.47 11.10 4 275769 16 64222943
Beta 2 microglobulin decreased 11.47 11.10 4 275769 16 64222943
Food allergy 11.46 11.10 10 275763 7841 64215118
Hypermetabolism 11.45 11.10 10 275763 303 64222656
Bone erosion 11.42 11.10 20 275753 11575 64211384
Metastases to breast 11.41 11.10 9 275764 236 64222723
Blastic plasmacytoid dendritic cell neoplasia 11.39 11.10 6 275767 76 64222883
Peritonitis 11.39 11.10 160 275613 24863 64198096
Tympanic membrane disorder 11.38 11.10 8 275765 175 64222784
Lymphadenitis viral 11.38 11.10 5 275768 41 64222918
Cord blood transplant therapy 11.38 11.10 5 275768 41 64222918
Acral lentiginous melanoma 11.38 11.10 5 275768 41 64222918
Haemophilus infection 11.36 11.10 25 275748 1860 64221099
Essential hypertension 11.35 11.10 4 275769 5190 64217769
Infection parasitic 11.33 11.10 11 275762 383 64222576
Photophobia 11.33 11.10 37 275736 17256 64205703
Bladder hypertrophy 11.31 11.10 13 275760 551 64222408
Subretinal hyperreflective exudation 11.31 11.10 3 275770 3 64222956
Breast prosthesis removal 11.31 11.10 3 275770 3 64222956
Follicle centre lymphoma, follicular grade I, II, III stage IV 11.31 11.10 3 275770 3 64222956
Bladder telangiectasia 11.31 11.10 3 275770 3 64222956
Non-obstructive cardiomyopathy 11.31 11.10 3 275770 3 64222956
Magnetic resonance imaging head abnormal 11.30 11.10 29 275744 2383 64220576
Myocarditis 11.27 11.10 117 275656 16926 64206033
Radiotherapy to brain 11.27 11.10 5 275768 42 64222917
Periorbital cellulitis 11.26 11.10 15 275758 741 64222218
Cheilitis 11.23 11.10 3 275770 4653 64218306
Heart rate abnormal 11.23 11.10 47 275726 4988 64217971
Escherichia urinary tract infection 11.22 11.10 89 275684 11948 64211011
Lumbar spinal stenosis 11.21 11.10 3 275770 4647 64218312
Periorbital infection 11.19 11.10 6 275767 79 64222880
Cancer fatigue 11.19 11.10 6 275767 79 64222880
Endothelial dysfunction 11.19 11.10 8 275765 180 64222779
Peritoneal abscess 11.18 11.10 9 275764 243 64222716
Psychomotor retardation 11.17 11.10 4 275769 5139 64217820
Squamous cell carcinoma of skin 11.17 11.10 88 275685 11788 64211171
Tendon rupture 11.13 11.10 18 275755 10749 64212210
Leukostasis syndrome 11.12 11.10 6 275767 80 64222879
Rectal fissure 11.12 11.10 15 275758 750 64222209

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01AA01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ALKYLATING AGENTS
Nitrogen mustard analogues
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:50903 carcinogen
MeSH PA D000477 Alkylating Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018906 Antineoplastic Agents, Alkylating
MeSH PA D018501 Antirheumatic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009153 Mutagens
MeSH PA D019653 Myeloablative Agonists
MeSH PA D009676 Noxae

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Systemic AL amyloidosis indication 23132008
Multiple myeloma indication 109989006 DOID:9538
Malignant lymphoma indication 118600007 DOID:0060058
Mycosis fungoides indication 118618005
Carcinoma of breast indication 254838004 DOID:3459
Retinoblastoma indication 370967009 DOID:768
Neuroblastoma indication 432328008 DOID:769
Treatment prior to tumor-specific T-cell infusion therapy indication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.39 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Cytochrome P450 3A4 Enzyme IC50 5.68 WOMBAT-PK

External reference:

IDSource
4018114 VUID
N0000146452 NUI
D00287 KEGG_DRUG
3002 RXNORM
4018114 VANDF
C0010583 UMLSCUI
CHEBI:4026 CHEBI
CHEMBL88 ChEMBL_ID
CHEMBL1200796 ChEMBL_ID
DB00531 DRUGBANK_ID
D003520 MESH_DESCRIPTOR_UI
2907 PUBCHEM_CID
7154 IUPHAR_LIGAND_ID
8N3DW7272P UNII
31952 MMSL
4519 MMSL
d00036 MMSL
002631 NDDF
387420009 SNOMEDCT_US
74470007 SNOMEDCT_US
6055-19-2 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0054-0382 CAPSULE 25 mg ORAL NDA 27 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0054-0383 CAPSULE 50 mg ORAL NDA 27 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3233 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3244 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3255 INJECTION, POWDER, FOR SOLUTION 2 g ORAL ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-935 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-936 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-937 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-938 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-939 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-942 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-943 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-944 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-945 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-955 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-956 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-957 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-982 TABLET 25 mg ORAL NDA authorized generic 27 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-984 TABLET 50 mg ORAL NDA 27 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 16714-857 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 16714-858 INJECTION, POWDER, FOR SOLUTION 2 g ORAL ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 16714-859 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 54868-5005 TABLET 50 mg ORAL ANDA 19 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 54868-5218 TABLET 25 mg ORAL ANDA 19 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 54879-021 CAPSULE 25 mg ORAL ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 54879-022 CAPSULE 50 mg ORAL ANDA 25 sections
Cyclophosphamide Human Prescription Drug Label 1 55150-270 INJECTION 500 mg INTRAVENOUS NDA 26 sections
Cyclophosphamide Human Prescription Drug Label 1 55150-271 INJECTION 1 g INTRAVENOUS NDA 26 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 62559-930 CAPSULE 25 mg ORAL ANDA 27 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 62559-931 CAPSULE 50 mg ORAL ANDA 27 sections