cyclophosphamide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
alkylating agents of the cyclophosphamide group 758 50-18-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cyclophosphamide
  • cyclophosphamid
  • cyclophosphamidum
  • cyclophosphan
  • cyclophosphane
  • cytophosphan
  • mitoxan
  • cyclophosphamide hydrate
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
  • Molecular weight: 261.08
  • Formula: C7H15Cl2N2O2P
  • CLOGP: 0.80
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 41.57
  • ALOGS: -1.24
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 40 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 6.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 19.15 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 74 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.73 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.87 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 8 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 16, 1959 FDA BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 5301.75 10.75 3499 150548 91128 46440887
Neutropenia 2577.67 10.75 2747 151300 140457 46391558
Bone marrow failure 1263.83 10.75 930 153117 28739 46503276
Acute myeloid leukaemia 1064.45 10.75 658 153389 15120 46516895
Product use in unapproved indication 953.89 10.75 1325 152722 88948 46443067
Disease recurrence 813.50 10.75 591 153456 17880 46514135
Mucosal inflammation 810.74 10.75 810 153237 38166 46493849
Myelodysplastic syndrome 738.43 10.75 523 153524 15188 46516827
Second primary malignancy 726.73 10.75 379 153668 6205 46525810
Cytomegalovirus infection 699.51 10.75 536 153511 17608 46514407
Leukopenia 688.65 10.75 981 153066 67362 46464653
Cytokine release syndrome 657.77 10.75 348 153699 5875 46526140
Pancytopenia 636.59 10.75 1064 152983 83994 46448021
Pyrexia 631.93 10.75 2545 151502 346257 46185758
Agranulocytosis 589.13 10.75 528 153519 21657 46510358
Haematotoxicity 581.98 10.75 333 153714 6600 46525415
Thrombocytopenia 571.35 10.75 1278 152769 125303 46406712
Rheumatoid arthritis 540.10 10.75 76 153971 240139 46291876
Acute graft versus host disease 538.43 10.75 264 153783 3766 46528249
Disease progression 533.06 10.75 1025 153022 90275 46441740
Ejection fraction decreased 532.72 10.75 455 153592 17482 46514533
Pneumocystis jirovecii pneumonia 526.25 10.75 422 153625 14826 46517189
Fall 502.87 10.75 229 153818 328868 46203147
Malignant neoplasm progression 477.34 10.75 806 153241 64120 46467895
Cystitis haemorrhagic 469.82 10.75 231 153816 3316 46528699
Cardiotoxicity 462.54 10.75 284 153763 6438 46525577
Diffuse large B-cell lymphoma recurrent 454.92 10.75 175 153872 1317 46530698
Febrile bone marrow aplasia 449.57 10.75 281 153766 6581 46525434
Neutrophil count decreased 448.48 10.75 631 153416 42795 46489220
Neutropenic sepsis 440.07 10.75 348 153699 11976 46520039
Premature menopause 434.86 10.75 140 153907 571 46531444
Completed suicide 429.63 10.75 11 154036 145909 46386106
Progressive multifocal leukoencephalopathy 417.24 10.75 326 153721 11020 46520995
Pain 404.14 10.75 594 153453 476354 46055661
Graft versus host disease 397.24 10.75 256 153791 6332 46525683
Chronic graft versus host disease 395.69 10.75 189 153858 2536 46529479
Neurotoxicity 395.20 10.75 342 153705 13375 46518640
Myelosuppression 381.85 10.75 265 153782 7438 46524577
Cardiomyopathy 363.77 10.75 350 153697 15723 46516292
Metastases to bone 362.80 10.75 363 153684 17113 46514902
Septic shock 361.28 10.75 669 153378 57224 46474791
Sepsis 356.36 10.75 1122 152925 134892 46397123
Product dose omission issue 352.32 10.75 65 153982 168455 46363560
Venoocclusive liver disease 350.94 10.75 202 153845 4049 46527966
Hypogammaglobulinaemia 341.98 10.75 217 153830 5221 46526794
Posterior reversible encephalopathy syndrome 330.06 10.75 323 153724 14818 46517197
Acute graft versus host disease in skin 330.03 10.75 172 153875 2810 46529205
White blood cell count decreased 324.96 10.75 959 153088 111272 46420743
Diffuse large B-cell lymphoma 317.35 10.75 214 153833 5724 46526291
Drug hypersensitivity 309.60 10.75 213 153834 243612 46288403
Neoplasm progression 295.33 10.75 401 153646 26282 46505733
Maternal exposure before pregnancy 279.76 10.75 178 153869 4303 46527712
Arthralgia 272.79 10.75 492 153555 364111 46167904
Acute lymphocytic leukaemia recurrent 270.21 10.75 134 153913 1961 46530054
Hepatitis B 269.41 10.75 162 153885 3531 46528484
Metastases to liver 268.04 10.75 327 153720 19258 46512757
Multiple organ dysfunction syndrome 263.67 10.75 549 153498 51161 46480854
Tumour lysis syndrome 261.91 10.75 206 153841 7030 46524985
Post transplant lymphoproliferative disorder 260.41 10.75 161 153886 3695 46528320
Anxiety 260.18 10.75 138 153909 181819 46350196
Pruritus 259.97 10.75 250 153797 242102 46289913
Left ventricular dysfunction 258.29 10.75 237 153810 10018 46521997
Palmar-plantar erythrodysaesthesia syndrome 253.59 10.75 325 153722 20126 46511889
Cytopenia 253.23 10.75 208 153839 7560 46524455
Injection site pain 249.90 10.75 30 154017 107122 46424893
Abdominal discomfort 246.78 10.75 95 153952 151070 46380945
Haemophagocytic lymphohistiocytosis 246.39 10.75 211 153836 8131 46523884
Joint swelling 246.33 10.75 120 153927 165953 46366062
Headache 245.04 10.75 788 153259 477564 46054451
Dizziness 241.67 10.75 474 153573 339940 46192075
Off label use 241.65 10.75 2104 151943 377737 46154278
Epstein-Barr virus infection 236.68 10.75 189 153858 6595 46525420
Nasopharyngitis 231.86 10.75 109 153938 153889 46378126
Weight increased 231.81 10.75 127 153920 164346 46367669
Graft versus host disease in skin 226.70 10.75 124 153923 2243 46529772
Ovarian failure 225.95 10.75 98 153949 1034 46530981
Acute promyelocytic leukaemia 221.40 10.75 91 153956 830 46531185
Aplasia 218.16 10.75 140 153907 3436 46528579
Therapy partial responder 215.62 10.75 154 153893 4528 46527487
Staphylococcal bacteraemia 211.48 10.75 155 153892 4749 46527266
Bronchopulmonary aspergillosis 208.05 10.75 183 153864 7313 46524702
Plasma cell myeloma 206.90 10.75 455 153592 44023 46487992
Pain in extremity 206.11 10.75 335 153712 258345 46273670
Acute lymphocytic leukaemia 205.80 10.75 123 153924 2650 46529365
Psoriasis 201.81 10.75 15 154032 78589 46453426
Neuropathy peripheral 199.73 10.75 707 153340 90186 46441829
Overdose 199.23 10.75 46 154001 101933 46430082
Peripheral swelling 188.87 10.75 147 153900 157924 46374091
Respiratory failure 188.53 10.75 714 153333 94102 46437913
Feeling abnormal 187.47 10.75 89 153958 124971 46407044
Platelet count decreased 186.47 10.75 738 153309 99286 46432729
Cardiac failure 186.18 10.75 634 153413 79314 46452701
Pleural effusion 185.49 10.75 649 153398 82303 46449712
Venoocclusive disease 183.27 10.75 101 153946 1855 46530160
Bone pain 181.18 10.75 446 153601 46444 46485571
Metastases to lung 175.41 10.75 196 153851 10500 46521515
Diffuse large B-cell lymphoma refractory 174.77 10.75 78 153969 886 46531129
Interstitial lung disease 171.47 10.75 477 153570 53472 46478543
Contraindicated product administered 170.95 10.75 29 154018 79918 46452097
Adenovirus infection 168.21 10.75 109 153938 2721 46529294
Synovitis 167.84 10.75 8 154039 61067 46470948
Drug abuse 163.05 10.75 12 154035 63396 46468619
Blood pressure increased 162.76 10.75 109 153938 126557 46405458
Breast cancer recurrent 162.76 10.75 121 153926 3790 46528225
Malaise 162.11 10.75 556 153491 330676 46201339
Injection site erythema 159.13 10.75 27 154020 74400 46457615
Breast cancer metastatic 158.10 10.75 210 153837 13468 46518547
Cardiac dysfunction 156.46 10.75 83 153964 1408 46530607
Somnolence 154.63 10.75 173 153874 156348 46375667
Cytomegalovirus viraemia 154.60 10.75 124 153923 4354 46527661
Lymphopenia 154.49 10.75 220 153827 15073 46516942
Drug interaction 151.60 10.75 274 153773 202820 46329195
Thrombotic microangiopathy 151.53 10.75 161 153886 8145 46523870
Blood follicle stimulating hormone increased 151.14 10.75 44 154003 116 46531899
Cytomegalovirus infection reactivation 146.21 10.75 79 153968 1393 46530622
Peripheral sensory neuropathy 146.01 10.75 142 153905 6461 46525554
Neutropenic colitis 145.18 10.75 91 153956 2141 46529874
Human herpesvirus 6 infection 145.11 10.75 94 153953 2345 46529670
Metastases to lymph nodes 143.64 10.75 141 153906 6490 46525525
Metastases to central nervous system 143.32 10.75 181 153866 11040 46520975
Swelling 142.20 10.75 121 153926 124390 46407625
BK virus infection 141.16 10.75 98 153949 2751 46529264
Rash 140.49 10.75 652 153395 355860 46176155
Musculoskeletal stiffness 140.42 10.75 74 153973 97919 46434096
Hospitalisation 137.72 10.75 22 154025 63363 46468652
Depression 137.50 10.75 218 153829 169886 46362129
Drug resistance 137.39 10.75 223 153824 17145 46514870
Stem cell transplant 135.41 10.75 80 153967 1686 46530329
Contusion 134.59 10.75 60 153987 87427 46444588
Hepatitis B reactivation 133.18 10.75 75 153972 1439 46530576
B-cell lymphoma recurrent 132.88 10.75 51 153996 381 46531634
Pemphigus 130.98 10.75 4 154043 45270 46486745
Neoplasm recurrence 130.34 10.75 87 153960 2286 46529729
Aspergillus infection 130.05 10.75 136 153911 6754 46525261
Anaemia 129.43 10.75 1351 152696 254428 46277587
Congestive cardiomyopathy 128.47 10.75 124 153923 5589 46526426
Graft versus host disease in gastrointestinal tract 127.01 10.75 88 153959 2462 46529553
Insomnia 125.28 10.75 220 153827 164704 46367311
Muscle spasms 124.97 10.75 133 153914 122980 46409035
Therapeutic product effect decreased 123.41 10.75 59 153988 82542 46449473
Bacteraemia 123.13 10.75 190 153857 13989 46518026
Gait disturbance 121.36 10.75 182 153865 145081 46386934
Arthropathy 121.29 10.75 64 153983 84636 46447379
Osteoarthritis 121.07 10.75 28 154019 61997 46470018
Fatigue 119.61 10.75 1360 152687 607337 45924678
Urticaria 118.94 10.75 128 153919 117764 46414251
Asthma 117.27 10.75 79 153968 91463 46440552
Therapy responder 116.72 10.75 44 154003 311 46531704
Abdominal pain upper 116.66 10.75 187 153860 145118 46386897
Acute graft versus host disease in intestine 115.03 10.75 71 153976 1624 46530391
Sinusitis 112.90 10.75 158 153889 129610 46402405
Bronchitis 111.50 10.75 111 153936 105868 46426147
Inappropriate schedule of product administration 110.85 10.75 38 154009 64975 46467040
Intentional product misuse 110.31 10.75 13 154034 47115 46484900
Leukaemia recurrent 110.17 10.75 63 153984 1246 46530769
Cytomegalovirus chorioretinitis 109.64 10.75 66 153981 1441 46530574
Primary hypogonadism 109.24 10.75 35 154012 140 46531875
Viral haemorrhagic cystitis 109.21 10.75 49 153998 564 46531451
Blood glucose increased 108.25 10.75 51 153996 71962 46460053
Stress 107.36 10.75 20 154027 51531 46480484
Suicide attempt 107.11 10.75 25 154022 55011 46477004
Psoriatic arthropathy 106.01 10.75 3 154044 36376 46495639
Arthritis 105.53 10.75 62 153985 77254 46454761
Mucormycosis 104.65 10.75 75 153972 2217 46529798
Injection site pruritus 103.68 10.75 7 154040 39736 46492279
Computerised tomogram thorax abnormal 102.64 10.75 61 153986 1300 46530715
Injection site swelling 102.62 10.75 8 154039 40319 46491696
Condition aggravated 102.51 10.75 438 153609 244614 46287401
Drug ineffective 102.35 10.75 1599 152448 676239 45855776
Glossodynia 101.99 10.75 13 154034 44360 46487655
Migraine 101.61 10.75 52 153995 69974 46462041
Injection site reaction 100.86 10.75 18 154029 47831 46484184
Staphylococcal sepsis 98.59 10.75 123 153924 7409 46524606
Ovarian atrophy 98.10 10.75 28 154019 67 46531948
Epstein-Barr virus associated lymphoproliferative disorder 97.96 10.75 61 153986 1418 46530597
Pulmonary haemorrhage 97.85 10.75 114 153933 6391 46525624
Product quality issue 96.88 10.75 5 154042 35643 46496372
Stomatitis 96.64 10.75 464 153583 67833 46464182
Loss of personal independence in daily activities 96.50 10.75 34 154013 57149 46474866
Fibromyalgia 96.37 10.75 6 154041 36457 46495558
White blood cell count abnormal 96.32 10.75 101 153946 5031 46526984
Injury 96.27 10.75 15 154032 44012 46488003
Metastasis 95.85 10.75 93 153954 4219 46527796
Recurrent cancer 95.44 10.75 64 153983 1695 46530320
Gastrooesophageal reflux disease 95.42 10.75 64 153983 74280 46457735
Multiple sclerosis relapse 95.25 10.75 13 154034 42112 46489903
Polyneuropathy 94.13 10.75 151 153896 11493 46520522
Acute respiratory distress syndrome 93.80 10.75 217 153830 21705 46510310
Injection site bruising 93.77 10.75 6 154041 35630 46496385
Capillary leak syndrome 93.39 10.75 65 153982 1832 46530183
Infection 92.94 10.75 756 153291 132836 46399179
Palpitations 92.16 10.75 107 153940 95152 46436863
Anti-Muellerian hormone level decreased 91.21 10.75 27 154020 77 46531938
Systemic candida 90.93 10.75 74 153973 2653 46529362
Incorrect dose administered 90.02 10.75 20 154027 45530 46486485
Blood cholesterol increased 88.94 10.75 13 154034 40000 46492015
Cerebrovascular accident 88.89 10.75 122 153925 100917 46431098
Urinary tract infection 88.87 10.75 399 153648 219867 46312148
Immune effector cell-associated neurotoxicity syndrome 88.35 10.75 44 154003 650 46531365
Lupus nephritis 87.94 10.75 67 153980 2179 46529836
Refractory anaemia with an excess of blasts 87.94 10.75 38 154009 397 46531618
International normalised ratio increased 87.92 10.75 23 154024 46860 46485155
Secondary immunodeficiency 87.11 10.75 49 153998 938 46531077
Enterococcal infection 86.54 10.75 111 153936 6876 46525139
Breast cancer 84.85 10.75 336 153711 45182 46486833
Acquired haemophilia 84.29 10.75 47 154000 884 46531131
Pneumatosis intestinalis 82.81 10.75 62 153985 1963 46530052
B-cell type acute leukaemia 82.36 10.75 26 154021 98 46531917
Biopsy lung abnormal 82.01 10.75 27 154020 120 46531895
Lymphocyte count decreased 82.00 10.75 227 153820 25362 46506653
Pulmonary alveolar haemorrhage 81.87 10.75 84 153963 4078 46527937
Colony stimulating factor therapy 81.65 10.75 33 154014 287 46531728
Fungaemia 81.51 10.75 61 153986 1930 46530085
Hypoxia 81.31 10.75 363 153684 51475 46480540
Subclavian vein thrombosis 81.07 10.75 59 153988 1787 46530228
Cytomegalovirus test positive 80.57 10.75 70 153977 2750 46529265
Chemotherapy 80.17 10.75 52 153995 1300 46530715
Respiratory syncytial virus infection 79.96 10.75 89 153958 4746 46527269
Varicella zoster virus infection 79.01 10.75 64 153983 2279 46529736
Transplant failure 78.74 10.75 50 153997 1204 46530811
Central nervous system lymphoma 78.74 10.75 50 153997 1204 46530811
Pneumonitis 78.44 10.75 239 153808 28181 46503834
Pre-existing disease 78.32 10.75 27 154020 142 46531873
Rhinovirus infection 78.16 10.75 77 153970 3559 46528456
Blood lactate dehydrogenase increased 78.10 10.75 194 153853 20306 46511709
Blood luteinising hormone increased 77.62 10.75 24 154023 83 46531932
JC virus infection 77.29 10.75 55 153992 1607 46530408
Organising pneumonia 77.25 10.75 88 153959 4814 46527201
Pseudocirrhosis 77.04 10.75 40 154007 648 46531367
Wound 76.53 10.75 23 154024 42779 46489236
Neutrophil count abnormal 76.51 10.75 64 153983 2386 46529629
Acute myelomonocytic leukaemia 75.88 10.75 28 154019 185 46531830
Gastrointestinal toxicity 75.57 10.75 82 153965 4249 46527766
Lymphadenopathy 74.77 10.75 262 153785 33226 46498789
Weight decreased 74.06 10.75 401 153646 210448 46321567
Leukoencephalopathy 73.72 10.75 78 153969 3926 46528089
Mobility decreased 72.74 10.75 56 153991 60538 46471477
Gene mutation 72.68 10.75 45 154002 1035 46530980
Lennox-Gastaut syndrome 72.18 10.75 29 154018 248 46531767
Unevaluable event 72.05 10.75 31 154016 46144 46485871
Bacterial sepsis 72.00 10.75 73 153974 3494 46528521
Klebsiella infection 71.99 10.75 99 153948 6563 46525452
Suicidal ideation 71.73 10.75 49 153998 56333 46475682
Wheezing 71.18 10.75 44 154003 53342 46478673
Acute graft versus host disease in liver 71.06 10.75 37 154010 603 46531412
Systemic mycosis 71.01 10.75 42 154005 887 46531128
Drug withdrawal syndrome 70.91 10.75 5 154042 27379 46504636
Chronic obstructive pulmonary disease 70.80 10.75 52 153995 57581 46474434
Myocardial infarction 70.52 10.75 134 153913 97394 46434621
Hypersensitivity 70.21 10.75 257 153790 150064 46381951
Systemic lupus erythematosus 70.00 10.75 67 153980 65113 46466902
Leukaemia cutis 69.67 10.75 22 154025 83 46531932
Pneumonia cytomegaloviral 69.21 10.75 55 153992 1905 46530110
Chronic graft versus host disease in skin 69.18 10.75 36 154011 586 46531429
Colitis 68.25 10.75 274 153773 37073 46494942
Therapy non-responder 68.21 10.75 293 153754 40859 46491156
Escherichia bacteraemia 67.95 10.75 63 153984 2698 46529317
Enterococcal bacteraemia 67.36 10.75 45 154002 1184 46530831
Balance disorder 67.36 10.75 68 153979 64453 46467562
Myeloid leukaemia 67.19 10.75 29 154018 302 46531713
Invasive ductal breast carcinoma 67.16 10.75 92 153955 6076 46525939
Lung infiltration 66.78 10.75 145 153902 13898 46518117
Amenorrhoea 66.03 10.75 111 153936 8784 46523231
Venous thrombosis 65.93 10.75 80 153967 4682 46527333
Fusarium infection 65.86 10.75 34 154013 544 46531471
Hypoglycaemia 65.53 10.75 50 153997 54299 46477716
Hepatic failure 64.98 10.75 250 153797 33166 46498849
Embolism 63.87 10.75 97 153950 7041 46524974
Smooth muscle cell neoplasm 63.81 10.75 33 154014 530 46531485
Nasal congestion 63.66 10.75 40 154007 48073 46483942
Confusional state 63.03 10.75 292 153755 159600 46372415
Bone marrow disorder 62.57 10.75 50 153997 1746 46530269
Myelopathy 62.35 10.75 58 153989 2494 46529521
Metastases to pleura 62.17 10.75 41 154006 1055 46530960
Myocarditis 62.06 10.75 100 153947 7639 46524376
Emotional distress 61.65 10.75 13 154034 30694 46501321
Alveolar soft part sarcoma 61.09 10.75 20 154027 87 46531928
Nephrolithiasis 60.49 10.75 17 154030 33034 46498981
Disseminated intravascular coagulation 60.30 10.75 168 153879 18837 46513178
Refractory cytopenia with multilineage dysplasia 59.33 10.75 21 154026 121 46531894
Blood pressure fluctuation 58.90 10.75 14 154033 30434 46501581
Hallucination 58.89 10.75 47 154000 49904 46482111
Hepatic enzyme increased 58.58 10.75 113 153934 81674 46450341
Serotonin syndrome 58.40 10.75 6 154041 24214 46507801
Acute leukaemia 58.39 10.75 40 154007 1098 46530917
Loss of consciousness 58.13 10.75 174 153873 108064 46423951
Chronic myelomonocytic leukaemia 58.05 10.75 26 154021 298 46531717
Pericardial effusion 58.02 10.75 201 153846 25342 46506673
Memory impairment 57.91 10.75 104 153943 77233 46454782
B-cell lymphoma 56.83 10.75 62 153985 3232 46528783
Skin toxicity 56.58 10.75 65 153982 3589 46528426
Blood pressure systolic increased 56.15 10.75 13 154034 28774 46503241
Metastases to skin 55.87 10.75 42 154005 1338 46530677
Drug intolerance 55.35 10.75 273 153774 146776 46385239
Complications of bone marrow transplant 55.20 10.75 28 154019 431 46531584
Tremor 55.11 10.75 196 153851 115443 46416572
Alveolar proteinosis 55.02 10.75 25 154022 297 46531718
Heart rate decreased 55.01 10.75 18 154029 31705 46500310
Pneumocystis jirovecii infection 54.81 10.75 40 154007 1217 46530798
Idiopathic pneumonia syndrome 54.61 10.75 26 154021 346 46531669
Influenza 54.31 10.75 135 153912 89135 46442880
Lactic acidosis 54.13 10.75 22 154025 33887 46498128
Premature delivery 53.95 10.75 178 153869 21891 46510124
Pseudomonal sepsis 53.81 10.75 48 153999 1954 46530061
Neutropenic infection 53.71 10.75 38 154009 1100 46530915
Neck pain 53.60 10.75 62 153985 55244 46476771
Aortitis 53.47 10.75 32 154015 691 46531324
Back pain 53.36 10.75 440 153607 209599 46322416
Adverse drug reaction 53.24 10.75 41 154006 44321 46487694
Anti-neutrophil cytoplasmic antibody positive vasculitis 53.21 10.75 47 154000 1888 46530127
Infection reactivation 53.11 10.75 33 154014 764 46531251
Hyperhidrosis 52.83 10.75 137 153910 89171 46442844
Dry mouth 52.78 10.75 62 153985 54864 46477151
Flatulence 52.58 10.75 15 154032 28863 46503152
Herpes simplex 52.11 10.75 89 153958 7134 46524881
Fluid retention 51.92 10.75 55 153992 50991 46481024
Pneumonia fungal 51.38 10.75 66 153981 4094 46527921
Joint injury 51.24 10.75 3 154044 19206 46512809
Musculoskeletal pain 51.00 10.75 96 153951 70032 46461983
Ventricular hypokinesia 50.84 10.75 65 153982 4013 46528002
Multiple sclerosis 50.80 10.75 10 154037 24781 46507234
Chronic lymphocytic leukaemia 50.76 10.75 55 153992 2845 46529170
Coronary artery disease 50.56 10.75 24 154023 33728 46498287
Acne 50.54 10.75 4 154043 19915 46512100
Bone marrow transplant 50.45 10.75 30 154017 640 46531375
5q minus syndrome 50.29 10.75 20 154027 166 46531849
Proteinuria 50.24 10.75 144 153903 16409 46515606
Blood stem cell transplant failure 50.20 10.75 19 154028 136 46531879
Femur fracture 50.00 10.75 30 154017 36967 46495048
Plasma cell myeloma recurrent 49.94 10.75 50 153997 2357 46529658
Bronchial polyp 49.74 10.75 16 154031 65 46531950
Multifocal micronodular pneumocyte hyperplasia 49.74 10.75 16 154031 65 46531950
Upper respiratory fungal infection 48.77 10.75 18 154029 119 46531896
Oedema peripheral 48.49 10.75 318 153729 159388 46372627
Clostridium difficile colitis 48.39 10.75 153 153894 18400 46513615
Cataract 48.39 10.75 47 154000 45368 46486647
Nervousness 47.91 10.75 17 154030 28458 46503557
Agitation 47.63 10.75 68 153979 55347 46476668
Plasma cell leukaemia 47.62 10.75 36 154011 1157 46530858
Sedation 47.46 10.75 9 154038 22901 46509114
Hyperkalaemia 46.86 10.75 59 153988 50650 46481365
Disseminated mucormycosis 46.63 10.75 17 154030 108 46531907
Microangiopathic haemolytic anaemia 46.46 10.75 25 154022 437 46531578
Staphylococcal infection 46.29 10.75 237 153810 35534 46496481
Lymphoma transformation 46.16 10.75 18 154029 141 46531874
Dyspepsia 46.13 10.75 98 153949 68374 46463641
Hypertransaminasaemia 45.71 10.75 57 153990 3431 46528584
Ascites 45.69 10.75 240 153807 36344 46495671
Chronic myeloid leukaemia 45.46 10.75 48 153999 2410 46529605
Surgery 45.42 10.75 19 154028 28766 46503249
Toxic cardiomyopathy 45.12 10.75 17 154030 120 46531895
Restlessness 45.12 10.75 14 154033 25510 46506505
Myeloproliferative neoplasm 45.03 10.75 25 154022 466 46531549
Chronic lymphocytic leukaemia recurrent 44.96 10.75 19 154028 187 46531828
Peripheral motor neuropathy 44.94 10.75 38 154009 1438 46530577
Vision blurred 44.35 10.75 126 153921 79582 46452433
Osteosarcoma 43.62 10.75 17 154030 133 46531882
Cytomegalovirus colitis 43.49 10.75 40 154007 1695 46530320
B-cell lymphoma refractory 43.49 10.75 15 154032 79 46531936
Sleep apnoea syndrome 43.36 10.75 10 154037 22191 46509824
Amnesia 43.30 10.75 44 154003 41587 46490428
Mantle cell lymphoma recurrent 43.07 10.75 16 154031 108 46531907
Aggression 42.94 10.75 11 154036 22733 46509282
Candida infection 42.92 10.75 166 153881 22074 46509941
Periarticular thenar erythema with onycholysis 42.91 10.75 11 154036 14 46532001
Nephroblastoma 42.82 10.75 16 154031 110 46531905
Chronic kidney disease 42.74 10.75 43 154004 40828 46491187
Parainfluenzae virus infection 42.54 10.75 40 154007 1744 46530271
Device related thrombosis 42.40 10.75 34 154013 1193 46530822
Device dislocation 42.22 10.75 10 154037 21792 46510223
Road traffic accident 41.86 10.75 13 154034 23678 46508337
Heart rate increased 41.77 10.75 118 153929 74673 46457342
Treatment noncompliance 41.76 10.75 23 154024 29708 46502307
Angioedema 41.59 10.75 41 154006 39301 46492714
Nephropathy toxic 41.35 10.75 82 153965 7372 46524643
Autoimmune haemolytic anaemia 41.16 10.75 60 153987 4198 46527817
Skin laceration 41.14 10.75 6 154041 18496 46513519
Throat irritation 41.11 10.75 22 154025 28879 46503136
Respiratory arrest 40.90 10.75 31 154016 33785 46498230
Pulmonary toxicity 40.90 10.75 63 153984 4630 46527385
Refractory cytopenia with unilineage dysplasia 40.88 10.75 25 154022 562 46531453
Mitral valve incompetence 40.79 10.75 146 153901 18706 46513309
Abdominal distension 40.77 10.75 116 153931 73235 46458780
Cardiomyopathy acute 40.68 10.75 18 154029 200 46531815
Herpes zoster meningoencephalitis 40.51 10.75 19 154028 244 46531771
Swollen tongue 40.50 10.75 23 154024 29209 46502806
Dry eye 40.40 10.75 25 154022 30297 46501718
Crying 40.35 10.75 10 154037 21131 46510884
Foot fracture 39.91 10.75 8 154039 19574 46512441
Toxicity to various agents 39.80 10.75 477 153570 211289 46320726
Irritability 39.78 10.75 23 154024 28923 46503092
Acquired gene mutation 39.77 10.75 25 154022 591 46531424
Bradycardia 39.75 10.75 101 153946 66197 46465818
Sleep disorder 39.65 10.75 58 153989 46737 46485278
Pulmonary fibrosis 39.62 10.75 151 153896 19941 46512074
Intestinal perforation 39.56 10.75 101 153946 10750 46521265
Klebsiella bacteraemia 39.40 10.75 32 154015 1144 46530871
Acute pulmonary oedema 39.27 10.75 83 153964 7808 46524207
Rash pruritic 39.25 10.75 53 153994 44162 46487853
Product prescribing error 39.21 10.75 9 154038 20038 46511977
Hyperpyrexia 39.16 10.75 47 154000 2719 46529296
Clostridium bacteraemia 39.14 10.75 17 154030 180 46531835
Hepatic function abnormal 39.07 10.75 220 153827 34201 46497814
B precursor type acute leukaemia 39.06 10.75 17 154030 181 46531834
Humoral immune defect 38.92 10.75 13 154034 61 46531954
Invasive lobular breast carcinoma 38.83 10.75 25 154022 617 46531398
Cutaneous calcification 38.66 10.75 14 154033 87 46531928
Hypoaesthesia 38.49 10.75 232 153815 118637 46413378
Gastric disorder 38.47 10.75 20 154027 26685 46505330
Disease susceptibility 38.25 10.75 17 154030 191 46531824
Portal hypertension 37.99 10.75 52 153995 3431 46528584
Encephalitis viral 37.82 10.75 36 154011 1594 46530421
Human polyomavirus infection 37.41 10.75 17 154030 202 46531813
Adenoviral hepatitis 37.32 10.75 18 154029 247 46531768
Accidental overdose 37.32 10.75 10 154037 20056 46511959
Therapeutic response unexpected 37.31 10.75 4 154043 15612 46516403
Leukaemia 37.17 10.75 50 153997 3245 46528770
Osteomyelitis bacterial 36.95 10.75 16 154031 168 46531847
Foot deformity 36.73 10.75 4 154043 15421 46516594
Bursitis 36.69 10.75 10 154037 19832 46512183
Ear infection 36.62 10.75 15 154032 22998 46509017
Joint stiffness 36.60 10.75 22 154025 27086 46504929
Clonal evolution 36.33 10.75 12 154035 54 46531961
Sciatica 36.29 10.75 9 154038 19011 46513004
Pneumomediastinum 36.29 10.75 31 154016 1190 46530825
Abortion spontaneous 36.10 10.75 55 153992 43591 46488424
Alveolitis 36.07 10.75 43 154004 2470 46529545
Depressed mood 36.06 10.75 34 154013 33285 46498730
Panic attack 35.96 10.75 11 154036 20231 46511784
Drug reaction with eosinophilia and systemic symptoms 35.85 10.75 27 154020 29521 46502494
Oxygen saturation decreased 35.83 10.75 113 153934 69051 46462964
Burning sensation 35.74 10.75 57 153990 44354 46487661
Disseminated toxoplasmosis 35.74 10.75 13 154034 82 46531933
Human bocavirus infection 35.62 10.75 19 154028 326 46531689
Hypoalbuminaemia 35.62 10.75 93 153954 10034 46521981
Eye swelling 35.58 10.75 11 154036 20092 46511923
Nightmare 35.51 10.75 6 154041 16592 46515423
Pulmonary embolism 35.51 10.75 529 153518 108056 46423959
Injection site rash 35.46 10.75 5 154042 15808 46516207
Metastases to the mediastinum 35.40 10.75 21 154026 446 46531569
Gastrointestinal necrosis 35.26 10.75 45 154002 2773 46529242
Hip fracture 35.24 10.75 22 154025 26534 46505481
Obliterative bronchiolitis 35.23 10.75 36 154011 1739 46530276
Cytogenetic abnormality 35.15 10.75 22 154025 516 46531499
Lupus vasculitis 35.15 10.75 21 154026 452 46531563
Plasmacytoma 34.92 10.75 42 154005 2435 46529580
Dyspnoea 34.91 10.75 1370 152677 514178 46017837
Ileus paralytic 34.86 10.75 56 153991 4267 46527748
Osteolysis 34.74 10.75 43 154004 2569 46529446
Cryptococcosis 34.65 10.75 26 154021 826 46531189
Intervertebral disc protrusion 34.64 10.75 12 154035 20393 46511622
Acute myeloid leukaemia recurrent 34.64 10.75 32 154015 1364 46530651
B-lymphocyte count abnormal 34.53 10.75 11 154036 43 46531972
Radiation skin injury 34.51 10.75 26 154021 831 46531184
T-cell lymphoma 34.40 10.75 23 154024 606 46531409
Engraft failure 34.38 10.75 19 154028 351 46531664
Viraemia 34.35 10.75 28 154019 1006 46531009
Gastrosplenic fistula 34.33 10.75 11 154036 44 46531971
Nocardiosis 34.31 10.75 34 154013 1583 46530432
Hypertension 34.01 10.75 450 153597 195906 46336109
Jugular vein thrombosis 33.98 10.75 43 154004 2627 46529388
Traumatic lung injury 33.98 10.75 32 154015 1398 46530617
Hepatitis E 33.88 10.75 30 154017 1209 46530806
Acute hepatitis B 33.84 10.75 18 154029 307 46531708
Candida sepsis 33.82 10.75 31 154016 1308 46530707
C-reactive protein abnormal 33.63 10.75 14 154033 21256 46510759
Device related infection 33.47 10.75 148 153899 20893 46511122
Nephrotic syndrome 33.37 10.75 59 153988 4862 46527153
Haematochezia 33.23 10.75 45 154002 37448 46494567
Choriocarcinoma 33.21 10.75 13 154034 103 46531912
Primary cardiac lymphoma 33.17 10.75 10 154037 31 46531984
Engraftment syndrome 33.15 10.75 17 154030 268 46531747
Limb injury 33.03 10.75 11 154036 19163 46512852
Adult T-cell lymphoma/leukaemia 32.98 10.75 18 154029 324 46531691
Medication error 32.92 10.75 32 154015 30879 46501136
Limb discomfort 32.90 10.75 17 154030 22759 46509256
Blood pressure decreased 32.80 10.75 89 153958 57070 46474945
Cervix disorder 32.65 10.75 20 154027 451 46531564
Brain abscess 32.63 10.75 34 154013 1681 46530334
Hepatotoxicity 32.57 10.75 166 153881 24843 46507172
Musculoskeletal disorder 32.43 10.75 6 154041 15539 46516476
Adverse event 32.39 10.75 39 154008 34145 46497870
Lip swelling 32.39 10.75 22 154025 25373 46506642
Plasmablastic lymphoma 32.27 10.75 16 154031 234 46531781
Osteonecrosis 32.22 10.75 169 153878 25575 46506440
Alternaria infection 32.17 10.75 14 154033 149 46531866
Diabetic ketoacidosis 32.16 10.75 10 154037 18200 46513815
Encephalitis 32.15 10.75 74 153973 7374 46524641
Fear 32.15 10.75 7 154040 16165 46515850
Splenomegaly 32.08 10.75 87 153960 9601 46522414
Minimal residual disease 32.04 10.75 11 154036 57 46531958
Lung consolidation 32.03 10.75 50 153997 3717 46528298
Left ventricular dilatation 31.96 10.75 17 154030 290 46531725
Withdrawal syndrome 31.95 10.75 10 154037 18124 46513891
Faeces discoloured 31.92 10.75 8 154039 16779 46515236
Visual impairment 31.78 10.75 113 153934 66576 46465439
Extravasation 31.70 10.75 37 154010 2078 46529937
Enterobacter infection 31.66 10.75 35 154012 1852 46530163
Lymphadenitis 31.65 10.75 41 154006 2564 46529451
Malignant transformation 31.55 10.75 17 154030 298 46531717
Therapy cessation 31.46 10.75 25 154022 26604 46505411
Sinus disorder 31.29 10.75 8 154039 16555 46515460
Discomfort 31.26 10.75 67 153980 46603 46485412
Irritable bowel syndrome 31.15 10.75 8 154039 16507 46515508
Ocular hyperaemia 31.12 10.75 13 154034 19697 46512318
Gastrointestinal fungal infection 31.10 10.75 16 154031 254 46531761
Frequent bowel movements 30.79 10.75 3 154044 12629 46519386
Encephalitis cytomegalovirus 30.76 10.75 20 154027 502 46531513
Graft versus host disease in liver 30.61 10.75 19 154028 439 46531576
Miller Fisher syndrome 30.56 10.75 12 154035 96 46531919
Quadriplegia 30.50 10.75 33 154014 1704 46530311
Ankle fracture 30.26 10.75 7 154040 15504 46516511
Angiocentric lymphoma 30.20 10.75 19 154028 450 46531565
Klebsiella sepsis 30.17 10.75 29 154018 1300 46530715
Acute monocytic leukaemia 30.16 10.75 11 154036 70 46531945
Unintentional medical device removal 30.12 10.75 54 153993 4499 46527516
Encephalopathy 30.11 10.75 202 153845 33387 46498628
Enterococcal sepsis 29.97 10.75 29 154018 1311 46530704
Laryngitis fungal 29.82 10.75 13 154034 139 46531876
Epstein Barr virus positive mucocutaneous ulcer 29.80 10.75 15 154032 227 46531788
Combined immunodeficiency 29.73 10.75 12 154035 104 46531911
Diffuse alveolar damage 29.66 10.75 23 154024 768 46531247
Mood altered 29.43 10.75 4 154043 13003 46519012
Nasal septum disorder 29.33 10.75 12 154035 108 46531907
Metastases to bone marrow 29.22 10.75 15 154032 237 46531778
Cerebral toxoplasmosis 29.18 10.75 22 154025 704 46531311
Product complaint 29.17 10.75 3 154044 12098 46519917
Thyroid disorder 29.09 10.75 3 154044 12073 46519942
Symptom masked 28.85 10.75 20 154027 560 46531455
Erythropoiesis abnormal 28.83 10.75 15 154032 244 46531771
Listeria sepsis 28.76 10.75 20 154027 563 46531452
Pulmonary veno-occlusive disease 28.64 10.75 24 154023 897 46531118
Gait inability 28.50 10.75 45 154002 35158 46496857
Rash macular 28.38 10.75 14 154033 19246 46512769
Sopor 28.34 10.75 15 154032 19813 46512202
Kidney infection 28.29 10.75 10 154037 16779 46515236
Skin discolouration 28.18 10.75 40 154007 32640 46499375
Seasonal allergy 28.13 10.75 5 154042 13329 46518686
Pneumothorax 28.07 10.75 109 153938 14520 46517495
Chest pain 28.06 10.75 411 153636 175913 46356102
Bacterial infection 28.06 10.75 117 153930 16099 46515916
Granulocytopenia 28.04 10.75 57 153990 5216 46526799
Perineal infection 27.97 10.75 12 154035 123 46531892
Blood culture positive 27.93 10.75 52 153995 4460 46527555
Pneumonitis chemical 27.92 10.75 13 154034 164 46531851
Gastroenteritis norovirus 27.82 10.75 30 154017 1543 46530472
Vasculitis 27.82 10.75 104 153943 13607 46518408
Triple negative breast cancer 27.80 10.75 12 154035 125 46531890
Escherichia sepsis 27.69 10.75 50 153997 4188 46527827
Vertigo 27.69 10.75 84 153963 51964 46480051
Primary mediastinal large B-cell lymphoma recurrent 27.64 10.75 10 154037 62 46531953
Metastases to chest wall 27.54 10.75 18 154029 456 46531559
Subdural hygroma 27.45 10.75 14 154033 218 46531797
Hepatosplenic T-cell lymphoma 27.42 10.75 20 154027 608 46531407
Oesophageal candidiasis 27.40 10.75 56 153991 5144 46526871
Rhabdomyolysis 27.38 10.75 61 153986 41848 46490167
Localised infection 27.30 10.75 23 154024 23778 46508237
Device issue 27.28 10.75 16 154031 19964 46512051
Pneumonia adenoviral 27.24 10.75 8 154039 22 46531993
Cholelithiasis 27.20 10.75 54 153993 38627 46493388
Nausea 27.13 10.75 1929 152118 685525 45846490
Injection site mass 27.03 10.75 8 154039 15032 46516983
Large intestinal ulcer perforation 26.98 10.75 10 154037 67 46531948
Gallbladder disorder 26.89 10.75 12 154035 17486 46514529
Cardiac cirrhosis 26.83 10.75 12 154035 137 46531878
Tendonitis 26.77 10.75 7 154040 14270 46517745
Flushing 26.63 10.75 116 153931 64498 46467517
Infusion related reaction 26.58 10.75 210 153837 100998 46431017
Human herpesvirus 8 infection 26.47 10.75 13 154034 186 46531829
Red blood cell sedimentation rate increased 26.40 10.75 22 154025 22867 46509148
Superior vena cava syndrome 26.38 10.75 19 154028 566 46531449
Dyskinesia 26.36 10.75 34 154013 28891 46503124
Hypersomnia 26.35 10.75 9 154038 15430 46516585
Primary adrenal insufficiency 26.16 10.75 9 154038 47 46531968
Heart rate abnormal 26.12 10.75 43 154004 3344 46528671
Atelectasis 26.08 10.75 127 153920 18663 46513352
Perineal necrosis 26.05 10.75 11 154036 108 46531907
Blood glucose decreased 25.98 10.75 15 154032 18877 46513138
Glaucoma 25.95 10.75 10 154037 15911 46516104
Pseudomonas infection 25.93 10.75 81 153966 9677 46522338
Hair follicle tumour benign 25.92 10.75 16 154031 366 46531649
Cerebral venous sinus thrombosis 25.82 10.75 31 154016 1794 46530221
Systemic scleroderma 25.76 10.75 22 154025 844 46531171
IIIrd nerve paralysis 25.66 10.75 20 154027 673 46531342
Cardio-respiratory arrest 25.59 10.75 106 153941 59763 46472252
Retinal toxicity 25.47 10.75 24 154023 1049 46530966
Haemoglobin abnormal 25.42 10.75 49 153998 4314 46527701
Lower limb fracture 25.40 10.75 5 154042 12393 46519622
Citrobacter bacteraemia 25.38 10.75 7 154040 14 46532001
Pneumonia influenzal 25.34 10.75 28 154019 1481 46530534
Hydrothorax 25.31 10.75 19 154028 604 46531411
Chest discomfort 25.27 10.75 184 153863 90085 46441930
Platelet count abnormal 25.27 10.75 38 154009 2734 46529281
Graft versus host disease in lung 25.27 10.75 15 154032 319 46531696
Leukaemic lymphoma 25.15 10.75 10 154037 83 46531932
Mesenteric abscess 25.15 10.75 10 154037 83 46531932
Dysphonia 25.02 10.75 56 153991 38358 46493657
Diffuse large B-cell lymphoma stage IV 24.85 10.75 13 154034 214 46531801
Blood creatine phosphokinase increased 24.84 10.75 33 154014 27691 46504324
Streptococcal bacteraemia 24.83 10.75 26 154021 1293 46530722
Respiratory tract infection fungal 24.63 10.75 16 154031 401 46531614
Cyst 24.54 10.75 5 154042 12095 46519920
Gout 24.53 10.75 4 154043 11352 46520663
Glomerulonephritis membranous 24.51 10.75 18 154029 553 46531462
Granulomatosis with polyangiitis 24.50 10.75 30 154017 1772 46530243
Thyroid dermatopathy 24.45 10.75 7 154040 17 46531998
Dysplasia 24.41 10.75 19 154028 638 46531377
Ligament sprain 24.37 10.75 3 154044 10516 46521499
Transient ischaemic attack 24.31 10.75 49 153998 34854 46497161
Glioma 24.25 10.75 14 154033 282 46531733
Carpal tunnel syndrome 24.18 10.75 11 154036 15848 46516167
Mantle cell lymphoma 23.96 10.75 18 154029 573 46531442
Primary amyloidosis 23.87 10.75 8 154039 38 46531977
Spinal stenosis 23.80 10.75 6 154041 12537 46519478
BK polyomavirus test positive 23.70 10.75 8 154039 39 46531976
Nail pigmentation 23.70 10.75 12 154035 184 46531831
Ototoxicity 23.65 10.75 23 154024 1046 46530969
Conjunctival scar 23.64 10.75 7 154040 20 46531995
Pelvic kidney 23.59 10.75 5 154042 0 46532015
Hyperviscosity syndrome 23.58 10.75 12 154035 186 46531829
Impaired healing 23.58 10.75 54 153993 36689 46495326
Feeling jittery 23.50 10.75 4 154043 11004 46521011
T-cell type acute leukaemia 23.48 10.75 9 154038 67 46531948
Head injury 23.46 10.75 28 154019 24608 46507407
Angioimmunoblastic T-cell lymphoma 23.44 10.75 10 154037 101 46531914
Gestational trophoblastic tumour 23.37 10.75 8 154039 41 46531974
Ovarian disorder 23.37 10.75 19 154028 680 46531335
Metabolic acidosis 23.30 10.75 59 153988 38721 46493294
Meningitis cryptococcal 23.29 10.75 24 154023 1171 46530844
Alopecia 23.25 10.75 701 153346 161713 46370302
Nasal abscess 23.20 10.75 11 154036 145 46531870
Acute lymphocytic leukaemia refractory 23.14 10.75 9 154038 70 46531945
Eye irritation 23.12 10.75 13 154034 16601 46515414
Lymphadenopathy mediastinal 23.10 10.75 34 154013 2400 46529615
Pleural neoplasm 22.93 10.75 10 154037 107 46531908
Peripheral sensorimotor neuropathy 22.91 10.75 24 154023 1194 46530821
Paraparesis 22.76 10.75 30 154017 1909 46530106
Retinal haemorrhage 22.74 10.75 50 153997 4833 46527182
Gastroenteritis viral 22.70 10.75 16 154031 18103 46513912
Hip arthroplasty 22.68 10.75 16 154031 18096 46513919
Primary mediastinal large B-cell lymphoma 22.68 10.75 7 154040 24 46531991
Metastatic malignant melanoma 22.67 10.75 25 154022 1319 46530696
Muscle spasticity 22.64 10.75 5 154042 11435 46520580
Restless legs syndrome 22.62 10.75 12 154035 15831 46516184
Feeling hot 22.56 10.75 58 153989 37870 46494145
Cytology abnormal 22.45 10.75 6 154041 10 46532005
Eye pain 22.35 10.75 36 154011 27904 46504111
Cardiac failure acute 22.35 10.75 68 153979 8010 46524005
Premature labour 22.34 10.75 85 153962 11214 46520801
Urinary tract infection bacterial 22.12 10.75 45 154002 4120 46527895
Lymphoma 22.09 10.75 77 153970 9736 46522279
Acute biphenotypic leukaemia 22.06 10.75 8 154039 50 46531965
Lymphangiosis carcinomatosa 22.01 10.75 23 154024 1141 46530874
Infusion site streaking 21.98 10.75 14 154033 339 46531676
Delayed engraftment 21.92 10.75 8 154039 51 46531964
Osteonecrosis of jaw 21.92 10.75 191 153856 34211 46497804
Skin hypopigmentation 21.73 10.75 14 154033 346 46531669
Blood iron decreased 21.66 10.75 5 154042 11092 46520923
Bone marrow transplant rejection 21.66 10.75 8 154039 53 46531962
Neuroblastoma recurrent 21.65 10.75 7 154040 29 46531986
Antithrombin III 21.64 10.75 11 154036 170 46531845
Tooth disorder 21.64 10.75 27 154020 23276 46508739
Fungal infection 21.54 10.75 169 153878 29351 46502664
Abdominal compartment syndrome 21.51 10.75 17 154030 584 46531431
Haematocrit decreased 21.49 10.75 193 153854 34864 46497151
Hormone receptor positive breast cancer 21.48 10.75 15 154032 425 46531590
Peripheral T-cell lymphoma unspecified 21.46 10.75 12 154035 227 46531788
Systolic dysfunction 21.41 10.75 24 154023 1290 46530725
Blast cells present 21.34 10.75 14 154033 357 46531658
Exostosis 21.32 10.75 4 154043 10259 46521756
Lower respiratory tract infection fungal 21.32 10.75 12 154035 230 46531785
Cerebellar stroke 21.31 10.75 11 154036 176 46531839
Haematocolpos 21.29 10.75 8 154039 56 46531959
Metastases to diaphragm 21.28 10.75 7 154040 31 46531984
Scedosporium infection 21.28 10.75 16 154031 510 46531505
HER2 positive breast cancer 21.26 10.75 9 154038 89 46531926
Growth hormone deficiency 21.21 10.75 10 154037 130 46531885
Adenoviral haemorrhagic cystitis 21.14 10.75 10 154037 131 46531884
Tuberculosis of central nervous system 21.14 10.75 14 154033 363 46531652
Rotator cuff syndrome 21.11 10.75 6 154041 11577 46520438
Haemoglobin decreased 21.07 10.75 566 153481 128383 46403632
Abnormal behaviour 21.06 10.75 23 154024 21035 46510980
Pelvic fracture 20.99 10.75 6 154041 11533 46520482
General physical health deterioration 20.91 10.75 515 153532 115254 46416761
Hepatomegaly 20.90 10.75 83 153964 11170 46520845
Toxic neuropathy 20.83 10.75 14 154033 372 46531643
Appendiceal abscess 20.82 10.75 11 154036 185 46531830
Administration site extravasation 20.80 10.75 17 154030 613 46531402
Therapy interrupted 20.79 10.75 5 154042 10786 46521229
Respiratory distress 20.75 10.75 178 153869 31738 46500277
Syphilis 20.75 10.75 10 154037 137 46531878
Steroid diabetes 20.66 10.75 17 154030 619 46531396
Geotrichum infection 20.53 10.75 15 154032 457 46531558
Metastases to thorax 20.51 10.75 11 154036 191 46531824
Cystitis viral 20.50 10.75 9 154038 98 46531917
Pneumonia 20.49 10.75 1473 152574 374847 46157168
Epstein-Barr viraemia 20.46 10.75 18 154029 719 46531296
Muscle rigidity 20.45 10.75 4 154043 9957 46522058
Mucosal toxicity 20.36 10.75 13 154034 316 46531699
Procedural pain 20.31 10.75 9 154038 13170 46518845
Necrotising colitis 20.29 10.75 16 154031 548 46531467
Necrotising gastritis 20.28 10.75 7 154040 37 46531978
Product administration error 20.24 10.75 21 154026 19660 46512355
Swelling face 20.23 10.75 98 153949 52961 46479054
Cytomegalovirus enteritis 20.20 10.75 11 154036 197 46531818
Bone lesion 20.20 10.75 48 153999 4883 46527132
Eye infection 20.19 10.75 3 154044 9120 46522895
Mucosal infection 20.18 10.75 9 154038 102 46531913
Sinus congestion 20.13 10.75 9 154038 13100 46518915
Single functional kidney 20.10 10.75 9 154038 103 46531912
Cholangiocarcinoma 20.07 10.75 21 154026 1043 46530972
Anger 20.07 10.75 7 154040 11845 46520170
Rash erythematous 20.07 10.75 53 153994 34297 46497718
Bone marrow necrosis 20.06 10.75 8 154039 67 46531948
Bronchiectasis 20.03 10.75 72 153975 9244 46522771
Groin pain 20.02 10.75 3 154044 9062 46522953
Labelled drug-drug interaction medication error 20.00 10.75 3 154044 9058 46522957
Cholecystitis chronic 19.97 10.75 5 154042 10494 46521521
Blood potassium increased 19.95 10.75 16 154031 16951 46515064
Cholecystectomy 19.95 10.75 3 154044 9039 46522976
Desmoplastic small round cell tumour 19.94 10.75 10 154037 150 46531865
Metastases to meninges 19.87 10.75 28 154019 1899 46530116
Helicobacter infection 19.75 10.75 7 154040 11729 46520286
Poor quality sleep 19.74 10.75 13 154034 15240 46516775
Tumour necrosis 19.68 10.75 18 154029 757 46531258
T-cell lymphoma recurrent 19.66 10.75 5 154042 6 46532009
Mucocutaneous ulceration 19.59 10.75 10 154037 156 46531859
Paranasal sinus mucosal hypertrophy 19.57 10.75 6 154041 20 46531995
Bone marrow infiltration 19.53 10.75 14 154033 414 46531601
Vascular compression 19.51 10.75 9 154038 111 46531904
Postictal state 19.49 10.75 20 154027 971 46531044
Lymphocytosis 19.48 10.75 30 154017 2204 46529811
Malignant neoplasm of pleura 19.46 10.75 8 154039 73 46531942
Blood lactate dehydrogenase abnormal 19.46 10.75 12 154035 274 46531741
Herpes simplex viraemia 19.42 10.75 10 154037 159 46531856
Primary immunodeficiency syndrome 19.40 10.75 7 154040 43 46531972
Illness 19.40 10.75 8 154039 12216 46519799
Respiratory depression 19.39 10.75 7 154040 11593 46520422
Hypoproteinaemia 19.33 10.75 27 154020 1816 46530199
High-grade B-cell lymphoma 19.23 10.75 5 154042 7 46532008
Respiratory tract congestion 19.23 10.75 9 154038 12755 46519260
Lymphoproliferative disorder 19.19 10.75 33 154014 2659 46529356
Gastrointestinal haemorrhage 19.19 10.75 163 153884 77210 46454805
Haematuria 19.18 10.75 153 153894 26705 46505310
Sneezing 19.17 10.75 9 154038 12732 46519283
Metastases to stomach 19.16 10.75 9 154038 116 46531899
Rhabdomyosarcoma recurrent 19.13 10.75 6 154041 22 46531993
Hepatosplenomegaly 19.13 10.75 31 154016 2379 46529636
Eye disorder 19.06 10.75 19 154028 18122 46513893
Pneumonia aspiration 19.05 10.75 48 153999 31557 46500458
Refractory cancer 19.00 10.75 7 154040 46 46531969
Carotid intima-media thickness increased 19.00 10.75 8 154039 78 46531937
Prescribed underdose 18.94 10.75 8 154039 12045 46519970
Medulloblastoma recurrent 18.91 10.75 8 154039 79 46531936
Diabetes mellitus inadequate control 18.88 10.75 10 154037 13204 46518811
Tooth fracture 18.87 10.75 4 154043 9411 46522604
Breast angiosarcoma 18.87 10.75 4 154043 0 46532015
Influenza like illness 18.81 10.75 112 153935 57458 46474557
Coma 18.81 10.75 114 153933 58235 46473780
Febrile infection 18.77 10.75 22 154025 1241 46530774
Mycobacterial infection 18.76 10.75 25 154022 1608 46530407
Enterocolitis infectious 18.68 10.75 24 154023 1489 46530526
Endocarditis 18.63 10.75 47 154000 4965 46527050
Neuroblastoma 18.63 10.75 7 154040 49 46531966
Incorrect route of product administration 18.58 10.75 16 154031 16367 46515648
Dry skin 18.55 10.75 71 153976 40945 46491070
Retching 18.48 10.75 10 154037 13047 46518968
Dystonia 18.47 10.75 7 154040 11250 46520765
Marrow hyperplasia 18.45 10.75 15 154032 537 46531478
Cystoid macular oedema 18.39 10.75 24 154023 1512 46530503
Lung diffusion test decreased 18.34 10.75 16 154031 632 46531383
Electrocardiogram QT prolonged 18.32 10.75 97 153950 51228 46480787
Sinus polyp 18.29 10.75 12 154035 306 46531709
Joint dislocation 18.28 10.75 7 154040 11179 46520836
Product storage error 18.26 10.75 8 154039 11784 46520231
Hepatic lesion 18.26 10.75 40 154007 3857 46528158
Listeria encephalitis 18.22 10.75 10 154037 182 46531833
Cancer in remission 18.16 10.75 6 154041 27 46531988
B-cell small lymphocytic lymphoma 18.16 10.75 6 154041 27 46531988
Acute kidney injury 18.08 10.75 617 153430 235238 46296777
Skin mass 18.07 10.75 48 153999 5232 46526783
Herpes zoster cutaneous disseminated 18.07 10.75 9 154038 133 46531882
Aplasia pure red cell 18.05 10.75 43 154004 4382 46527633
Thinking abnormal 18.04 10.75 5 154042 9809 46522206
Abdominal pain 18.04 10.75 600 153447 229431 46302584
Prescribed overdose 17.99 10.75 6 154041 10443 46521572
Central nervous system leukaemia 17.91 10.75 8 154039 91 46531924
Merycism 17.89 10.75 9 154038 136 46531879
Recall phenomenon 17.84 10.75 15 154032 563 46531452
Pharyngeal inflammation 17.82 10.75 15 154032 564 46531451
Epstein-Barr virus test positive 17.80 10.75 15 154032 565 46531450
Poor venous access 17.78 10.75 3 154044 8305 46523710
Guillain-Barre syndrome 17.77 10.75 36 154011 3286 46528729
Sarcoidosis 17.76 10.75 47 154000 5112 46526903
Pleural disorder 17.75 10.75 15 154032 567 46531448
Wrong technique in product usage process 17.71 10.75 106 153941 54316 46477699
Germ cell cancer 17.61 10.75 7 154040 58 46531957
Autoimmune neutropenia 17.61 10.75 7 154040 58 46531957
Lethargy 17.55 10.75 98 153949 51073 46480942
Opsoclonus myoclonus 17.54 10.75 9 154038 142 46531873
Cryptosporidiosis infection 17.54 10.75 11 154036 259 46531756
Enterobacter bacteraemia 17.54 10.75 11 154036 259 46531756
Drug dependence 17.52 10.75 24 154023 19877 46512138
Paraneoplastic pemphigus 17.49 10.75 6 154041 31 46531984
Fusobacterium infection 17.49 10.75 6 154041 31 46531984
Chronic cutaneous lupus erythematosus 17.46 10.75 8 154039 97 46531918
Type 2 diabetes mellitus 17.46 10.75 24 154023 19851 46512164
Rectal haemorrhage 17.44 10.75 66 153981 38189 46493826
Lung disorder 17.42 10.75 219 153828 43085 46488930
Impaired work ability 17.42 10.75 10 154037 12626 46519389
Speech disorder 17.41 10.75 61 153986 36106 46495909
Clostridium difficile infection 17.38 10.75 142 153905 24961 46507054
Hepatitis C RNULL increased 17.38 10.75 9 154038 145 46531870
Hallucination, visual 17.35 10.75 20 154027 17853 46514162
Chronic lymphocytic leukaemia transformation 17.33 10.75 6 154041 32 46531983
Hyperuricaemia 17.29 10.75 44 154003 4673 46527342
Disorientation 17.29 10.75 63 153984 36855 46495160
Vena cava thrombosis 17.26 10.75 28 154019 2151 46529864
Hepatic calcification 17.23 10.75 5 154042 13 46532002
B-cell aplasia 17.23 10.75 5 154042 13 46532002
Burkitt's lymphoma 17.23 10.75 5 154042 13 46532002
Clostridium test positive 17.21 10.75 26 154021 1878 46530137
Middle insomnia 17.21 10.75 5 154042 9510 46522505
Chylothorax 17.21 10.75 11 154036 268 46531747
Gastric stenosis 17.21 10.75 7 154040 62 46531953
Hilar lymphadenopathy 17.16 10.75 19 154028 1007 46531008
Endocrine ophthalmopathy 17.14 10.75 11 154036 270 46531745
B-lymphocyte count decreased 17.13 10.75 17 154030 793 46531222
Leukocytosis 17.10 10.75 134 153913 23264 46508751
Fungal sepsis 17.08 10.75 20 154027 1127 46530888
Toxoplasmosis 17.03 10.75 22 154025 1372 46530643
Iron deficiency anaemia 16.98 10.75 19 154028 17187 46514828
CD4/CD8 ratio decreased 16.96 10.75 5 154042 14 46532001
Metastases to breast 16.92 10.75 11 154036 276 46531739
Aplastic anaemia 16.86 10.75 57 153990 7096 46524919
Orthostatic hypotension 16.85 10.75 35 154012 24623 46507392
Mycobacterium abscessus infection 16.81 10.75 15 154032 611 46531404
Pulmonary infarction 16.80 10.75 31 154016 2640 46529375
Disseminated cryptococcosis 16.72 10.75 11 154036 282 46531733
Gait apraxia 16.70 10.75 5 154042 15 46532000
Mediastinitis 16.67 10.75 10 154037 217 46531798
Haematopoietic stem cell mobilisation 16.64 10.75 4 154043 3 46532012
Cytokine abnormal 16.64 10.75 4 154043 3 46532012
Metastases to spine 16.61 10.75 31 154016 2663 46529352
Cough 16.58 10.75 607 153440 229642 46302373
Haematoma 16.55 10.75 52 153995 31820 46500195
Liver function test abnormal 16.51 10.75 88 153959 46399 46485616
Death 16.50 10.75 1303 152744 334245 46197770
Central nervous system infection 16.48 10.75 15 154032 627 46531388
Leukoerythroblastosis 16.46 10.75 10 154037 222 46531793
Pneumonia bacterial 16.38 10.75 55 153992 6824 46525191
Blood pressure abnormal 16.37 10.75 10 154037 12207 46519808
Pain in jaw 16.35 10.75 68 153979 38304 46493711
Enteral nutrition 16.34 10.75 6 154041 39 46531976
Hyperbilirubinaemia 16.28 10.75 73 153974 10365 46521650
Haemolytic anaemia 16.24 10.75 70 153977 9772 46522243
Pulse waveform abnormal 16.21 10.75 7 154040 73 46531942
Morganella infection 16.19 10.75 13 154034 457 46531558
Metastases to spleen 16.13 10.75 8 154039 117 46531898
Ankle brachial index decreased 16.13 10.75 7 154040 74 46531941
Neonatal lupus erythematosus 16.11 10.75 4 154043 4 46532011
Chronic graft versus host disease in liver 16.11 10.75 9 154038 170 46531845
Transient hypogammaglobulinaemia of infancy 16.09 10.75 6 154041 41 46531974
Malignant pleural effusion 16.06 10.75 29 154018 2429 46529586
Fungal oesophagitis 16.03 10.75 14 154033 554 46531461
Ill-defined disorder 15.97 10.75 41 154006 26786 46505229
Thrombotic thrombocytopenic purpura 15.95 10.75 38 154009 3872 46528143
Jejunal stenosis 15.85 10.75 6 154041 43 46531972
Meningoencephalitis viral 15.84 10.75 11 154036 309 46531706
Underdose 15.83 10.75 25 154022 19533 46512482
Trichosporon infection 15.81 10.75 10 154037 239 46531776
VIth nerve paresis 15.80 10.75 7 154040 78 46531937
Pneumonia respiratory syncytial viral 15.80 10.75 15 154032 662 46531353
Metastases to peritoneum 15.75 10.75 30 154017 2618 46529397
Psychomotor hyperactivity 15.73 10.75 6 154041 9607 46522408
Microscopic polyangiitis 15.72 10.75 8 154039 124 46531891
Myocardial fibrosis 15.69 10.75 14 154033 570 46531445
Venous haemorrhage 15.60 10.75 9 154038 181 46531834
Chorioretinitis 15.50 10.75 11 154036 320 46531695
Corynebacterium infection 15.49 10.75 12 154035 400 46531615
Chromaturia 15.47 10.75 16 154031 15003 46517012
Endocarditis bacterial 15.47 10.75 14 154033 581 46531434
Post procedural infection 15.46 10.75 3 154044 7510 46524505
Respiratory tract infection 15.41 10.75 159 153888 29813 46502202
Hepatic necrosis 15.35 10.75 47 154000 5554 46526461
Gastritis fungal 15.34 10.75 7 154040 84 46531931
Enterocolitis 15.30 10.75 50 153997 6118 46525897
Nail disorder 15.28 10.75 59 153988 7837 46524178
Peritonitis viral 15.28 10.75 6 154041 48 46531967
Mucoepidermoid carcinoma 15.28 10.75 6 154041 48 46531967
Diverticulum 15.26 10.75 9 154038 11197 46520818
Red blood cell schistocytes present 15.24 10.75 10 154037 255 46531760
Central nervous system enteroviral infection 15.23 10.75 5 154042 22 46531993
Leukaemic infiltration 15.23 10.75 5 154042 22 46531993
Primitive neuroectodermal tumour 15.22 10.75 4 154043 6 46532009
Human herpes virus 8 test positive 15.22 10.75 4 154043 6 46532009
Epstein-Barr virus infection reactivation 15.21 10.75 10 154037 256 46531759
Blood fibrinogen decreased 15.19 10.75 15 154032 695 46531320
Acute generalised exanthematous pustulosis 15.18 10.75 6 154041 9399 46522616
Listeriosis 15.15 10.75 19 154028 1150 46530865
Laboratory test abnormal 15.13 10.75 33 154014 22814 46509201
Superior mesenteric artery syndrome 15.13 10.75 7 154040 87 46531928
Gas gangrene 15.06 10.75 7 154040 88 46531927
Opportunistic infection 15.05 10.75 23 154024 1678 46530337
Myalgia 15.00 10.75 301 153746 122787 46409228
Alpha haemolytic streptococcal infection 15 10.75 15 154032 706 46531309
Colitis ulcerative 14.99 10.75 22 154025 17710 46514305
Bronchiolitis 14.98 10.75 27 154020 2258 46529757
Metastatic lymphoma 14.92 10.75 7 154040 90 46531925
Mood swings 14.92 10.75 19 154028 16233 46515782
Hepatocellular injury 14.89 10.75 156 153891 29366 46502649
Hereditary motor and sensory neuropathy 14.86 10.75 6 154041 52 46531963
Chromosome analysis abnormal 14.86 10.75 8 154039 140 46531875
Hypofibrinogenaemia 14.85 10.75 18 154029 1052 46530963
Parvovirus infection 14.81 10.75 9 154038 200 46531815
Xerophthalmia 14.81 10.75 10 154037 268 46531747
Blood pressure diastolic decreased 14.80 10.75 15 154032 14196 46517819
Blood immunoglobulin G decreased 14.79 10.75 24 154023 1844 46530171
Blood calcium decreased 14.72 10.75 18 154029 15655 46516360
Grip strength decreased 14.71 10.75 5 154042 8601 46523414
Acquired macroglossia 14.71 10.75 7 154040 93 46531922
Parkinsonism 14.71 10.75 4 154043 7944 46524071
Hemiparesis 14.70 10.75 115 153932 19954 46512061
Lymphocytic leukaemia 14.66 10.75 8 154039 144 46531871
Blast cell count increased 14.64 10.75 11 154036 350 46531665
Gestational diabetes 14.61 10.75 3 154044 7216 46524799
Ear pain 14.56 10.75 32 154015 22060 46509955
Ovarian cyst 14.52 10.75 15 154032 14072 46517943
Joint effusion 14.50 10.75 11 154036 11984 46520031
Troponin I increased 14.49 10.75 24 154023 1876 46530139
Stenotrophomonas infection 14.47 10.75 22 154025 1598 46530417
Lip and/or oral cavity cancer 14.46 10.75 10 154037 279 46531736
Musculoskeletal discomfort 14.45 10.75 15 154032 14041 46517974
Pyomyositis 14.43 10.75 11 154036 358 46531657
Upper-airway cough syndrome 14.42 10.75 4 154043 7843 46524172
Lupus-like syndrome 14.42 10.75 4 154043 7840 46524175
Anal infection 14.38 10.75 6 154041 57 46531958
Cardiogenic shock 14.36 10.75 98 153949 16286 46515729
Pharyngitis streptococcal 14.34 10.75 5 154042 8463 46523552
Rhinocerebral mucormycosis 14.32 10.75 8 154039 151 46531864
Lymph node pain 14.32 10.75 19 154028 1217 46530798
Cytomegalovirus enterocolitis 14.25 10.75 13 154034 545 46531470
Body height decreased 14.25 10.75 7 154040 9645 46522370
Median nerve injury 14.24 10.75 5 154042 28 46531987
Klebsiella test positive 14.21 10.75 17 154030 980 46531035
Central nervous system viral infection 14.20 10.75 7 154040 101 46531914
Non-Hodgkin's lymphoma recurrent 14.18 10.75 4 154043 9 46532006
Hypotelorism of orbit 14.18 10.75 4 154043 9 46532006
Spinal cord compression 14.17 10.75 35 154012 3649 46528366
Myasthenia gravis crisis 14.17 10.75 11 154036 368 46531647
Autologous haematopoietic stem cell transplant 14.15 10.75 3 154044 0 46532015
Ovarian Sertoli-Leydig cell tumour 14.15 10.75 3 154044 0 46532015
Eosinophilic fasciitis 14.14 10.75 7 154040 102 46531913
Pleurodesis 14.10 10.75 5 154042 29 46531986
Metastases to retroperitoneum 14.09 10.75 8 154039 156 46531859
Lymphangitis 14.06 10.75 16 154031 874 46531141
Emotional disorder 14.02 10.75 12 154035 12312 46519703
Melaena 13.94 10.75 46 154001 27726 46504289
Oropharyngeal pain 13.93 10.75 167 153880 74001 46458014
Eczema 13.90 10.75 29 154018 20371 46511644
Clonal haematopoiesis 13.89 10.75 4 154043 10 46532005
Metaplasia 13.89 10.75 12 154035 468 46531547
Delusion 13.86 10.75 10 154037 11178 46520837
Metastases to uterus 13.86 10.75 6 154041 63 46531952
Soft tissue infection 13.76 10.75 24 154023 1956 46530059
Disseminated tuberculosis 13.76 10.75 29 154018 2723 46529292
Haptoglobin decreased 13.74 10.75 13 154034 571 46531444
Hypermetabolism 13.73 10.75 7 154040 109 46531906
Rib fracture 13.73 10.75 26 154021 18928 46513087
Acute interstitial pneumonitis 13.71 10.75 14 154033 676 46531339
Angina pectoris 13.68 10.75 44 154003 26731 46505284
Menopause 13.68 10.75 25 154022 2114 46529901
Endocardial fibrosis 13.62 10.75 4 154043 11 46532004
Out of specification test results 13.61 10.75 6 154041 66 46531949
Angina unstable 13.59 10.75 4 154043 7544 46524471
Right ventricular failure 13.58 10.75 20 154027 16073 46515942
Myelitis 13.57 10.75 18 154029 1152 46530863
Microsporidia infection 13.57 10.75 9 154038 234 46531781
Sweat gland tumour 13.56 10.75 7 154040 112 46531903
Oedema due to cardiac disease 13.55 10.75 5 154042 33 46531982
Splenic infarction 13.55 10.75 21 154026 1551 46530464
Hydrocephalus 13.44 10.75 41 154006 4836 46527179
Jejunal ulcer perforation 13.43 10.75 5 154042 34 46531981
Premature baby 13.39 10.75 104 153943 18008 46514007
T-cell prolymphocytic leukaemia 13.36 10.75 4 154043 12 46532003
Hiatus hernia 13.35 10.75 25 154022 18277 46513738
Chronic hepatitis 13.34 10.75 15 154032 809 46531206
Neutrophilia 13.32 10.75 30 154017 2947 46529068
Radiation necrosis 13.29 10.75 10 154037 319 46531696
Pulmonary necrosis 13.29 10.75 7 154040 117 46531898
Nervous system disorder 13.27 10.75 95 153952 16034 46515981
Osteoporosis 13.26 10.75 79 153968 40529 46491486
Metastases to abdominal cavity 13.24 10.75 11 154036 406 46531609
Arteritis 13.22 10.75 12 154035 500 46531515
Movement disorder 13.20 10.75 22 154025 16827 46515188
Urinary retention 13.20 10.75 43 154004 26018 46505997
Haemolysis 13.17 10.75 47 154000 6012 46526003
Upper respiratory tract infection 13.16 10.75 140 153907 63416 46468599
Secretion discharge 13.14 10.75 7 154040 9212 46522803
Affect lability 13.13 10.75 5 154042 8015 46524000
Acral peeling skin syndrome 13.12 10.75 4 154043 13 46532002
Diarrhoea 13.12 10.75 1632 152415 557970 45974045
Precursor T-lymphoblastic lymphoma/leukaemia 13.07 10.75 5 154042 37 46531978
Ocular vasculitis 13.07 10.75 5 154042 37 46531978
Muscle tightness 13.04 10.75 9 154038 10296 46521719
Synovial cyst 13.03 10.75 4 154043 7342 46524673
Body temperature decreased 13.02 10.75 15 154032 13394 46518621
Oral fungal infection 13.01 10.75 27 154020 2507 46529508
Vascular access complication 13.00 10.75 16 154031 950 46531065
Necrosis 13.00 10.75 40 154007 4740 46527275
Trichodysplasia spinulosa 12.97 10.75 11 154036 418 46531597
Delirium 12.93 10.75 71 153976 37157 46494858
Microangiopathy 12.90 10.75 15 154032 839 46531176
Hypoglossal nerve paresis 12.88 10.75 7 154040 125 46531890
Increased appetite 12.87 10.75 6 154041 8521 46523494
Pulmonary vein stenosis 12.87 10.75 6 154041 76 46531939
Hallucination, auditory 12.83 10.75 10 154037 10746 46521269
Bronchostenosis 12.82 10.75 10 154037 337 46531678
Duodenal ulcer perforation 12.80 10.75 6 154041 8496 46523519
Cardiac tamponade 12.80 10.75 38 154009 4416 46527599
Intercepted product administration error 12.80 10.75 6 154041 77 46531938
Injection site phlebitis 12.78 10.75 7 154040 127 46531888
Metastases to ovary 12.77 10.75 10 154037 339 46531676
Natural killer-cell leukaemia 12.73 10.75 5 154042 40 46531975
Cytomegalovirus gastritis 12.66 10.75 8 154039 191 46531824
Cerebral aspergillosis 12.64 10.75 10 154037 344 46531671
Human metapneumovirus test positive 12.63 10.75 5 154042 41 46531974
Stenotrophomonas sepsis 12.63 10.75 5 154042 41 46531974
Diverticulitis 12.61 10.75 61 153986 32978 46499037
Aphasia 12.59 10.75 147 153900 28420 46503595
Fungal skin infection 12.59 10.75 33 154014 3569 46528446
Eating disorder 12.57 10.75 18 154029 14636 46517379
Evans syndrome 12.55 10.75 8 154039 194 46531821
Micrococcal sepsis 12.52 10.75 5 154042 42 46531973
Hypoperfusion 12.52 10.75 19 154028 1378 46530637
Mucosal erosion 12.51 10.75 19 154028 1379 46530636
Enterocolitis haemorrhagic 12.49 10.75 20 154027 1520 46530495
Beta 2 microglobulin decreased 12.48 10.75 4 154043 16 46531999
Hepatic candidiasis 12.48 10.75 4 154043 16 46531999
Granuloma 12.47 10.75 34 154013 3764 46528251
Rhinorrhoea 12.46 10.75 99 153948 47566 46484449
Dyspraxia 12.44 10.75 8 154039 197 46531818
Acute lung injury 12.42 10.75 18 154029 1253 46530762
Focal nodular hyperplasia 12.41 10.75 11 154036 444 46531571
Oligohydramnios 12.40 10.75 43 154004 5422 46526593
Increased tendency to bruise 12.36 10.75 8 154039 9466 46522549
Akathisia 12.32 10.75 5 154042 7709 46524306
Salivary gland cancer 12.31 10.75 7 154040 137 46531878
Bladder disorder 12.30 10.75 4 154043 7074 46524941
Deafness 12.29 10.75 93 153954 15975 46516040
Acinetobacter infection 12.27 10.75 19 154028 1403 46530612
Pregnancy 12.25 10.75 47 154000 27090 46504925
Extramedullary haemopoiesis 12.22 10.75 5 154042 45 46531970
Arteritis infective 12.22 10.75 5 154042 45 46531970
Liver scan abnormal 12.22 10.75 5 154042 45 46531970
Pseudomonal bacteraemia 12.20 10.75 18 154029 1273 46530742
Hypertriglyceridaemia 12.19 10.75 44 154003 5660 46526355
Diabetes mellitus 12.18 10.75 106 153941 49959 46482056
Bladder perforation 12.17 10.75 7 154040 140 46531875
Scar 12.16 10.75 13 154034 12006 46520009
Breast neoplasm 12.16 10.75 18 154029 1277 46530738
Skin cancer 12.14 10.75 7 154040 8816 46523199
Subretinal hyperreflective exudation 12.08 10.75 3 154044 3 46532012
Allogenic bone marrow transplantation therapy 12.08 10.75 3 154044 3 46532012
Breast prosthesis removal 12.08 10.75 3 154044 3 46532012
Rubulavirus test positive 12.08 10.75 3 154044 3 46532012
Precursor B-lymphoblastic lymphoma recurrent 12.08 10.75 3 154044 3 46532012
Ventricular dysfunction 12.07 10.75 28 154019 2804 46529211
Atrial thrombosis 12.05 10.75 19 154028 1425 46530590
Oral candidiasis 12.05 10.75 99 153948 17433 46514582
Blood urea increased 12.04 10.75 43 154004 25309 46506706
Norovirus test positive 12.04 10.75 7 154040 143 46531872
Acute hepatitis C 12.03 10.75 6 154041 89 46531926
Meningitis 12.00 10.75 46 154001 6090 46525925
Low cardiac output syndrome 11.99 10.75 9 154038 286 46531729
Laryngitis 11.97 10.75 8 154039 9308 46522707
Left ventricular failure 11.97 10.75 40 154007 4950 46527065
Carotidynia 11.95 10.75 7 154040 145 46531870
Aspartate aminotransferase abnormal 11.95 10.75 15 154032 909 46531106
Carbohydrate antigen 15-3 increased 11.95 10.75 15 154032 909 46531106
Dental caries 11.94 10.75 10 154037 10369 46521646
Facial discomfort 11.94 10.75 4 154043 19 46531996
Lymphocytic infiltration 11.91 10.75 14 154033 792 46531223
Small fibre neuropathy 11.91 10.75 7 154040 146 46531869
Candida pneumonia 11.91 10.75 7 154040 146 46531869
Enteritis 11.89 10.75 49 153998 6706 46525309
Head discomfort 11.87 10.75 10 154037 10341 46521674
Cystitis 11.86 10.75 86 153961 42155 46489860
Radiation injury 11.86 10.75 11 154036 471 46531544
Onycholysis 11.86 10.75 17 154030 1171 46530844
Transaminases increased 11.86 10.75 142 153905 27619 46504396
Neuromuscular toxicity 11.83 10.75 7 154040 148 46531867
Large intestine perforation 11.82 10.75 53 153994 7527 46524488
Toothache 11.80 10.75 23 154024 16569 46515446
Therapeutic product effect incomplete 11.79 10.75 184 153863 77969 46454046
Product dispensing error 11.77 10.75 8 154039 9225 46522790
Malignant neoplasm of orbit 11.77 10.75 4 154043 20 46531995
Ureteritis 11.77 10.75 4 154043 20 46531995
Bone sarcoma 11.77 10.75 4 154043 20 46531995
Duodenal stenosis 11.74 10.75 12 154035 580 46531435
Dandy-Walker syndrome 11.73 10.75 6 154041 94 46531921
Bone density decreased 11.71 10.75 9 154038 9743 46522272
Candida test positive 11.71 10.75 15 154032 928 46531087
Staphylococcus test positive 11.68 10.75 32 154015 3552 46528463
Malignant ascites 11.68 10.75 15 154032 930 46531085
Viral test positive 11.66 10.75 7 154040 152 46531863
Atrioventricular block first degree 11.66 10.75 3 154044 6183 46525832
Osteopenia 11.65 10.75 24 154023 16937 46515078
Intervertebral disc degeneration 11.64 10.75 16 154031 13236 46518779
Arachnoid cyst 11.63 10.75 8 154039 221 46531794
Constipation 11.63 10.75 463 153584 173634 46358381
Stomatococcal infection 11.62 10.75 6 154041 96 46531919
Meningoencephalitis herpetic 11.62 10.75 16 154031 1062 46530953
Tachycardia induced cardiomyopathy 11.59 10.75 5 154042 52 46531963
PIK3CA-activated mutation 11.59 10.75 12 154035 589 46531426
Hypogonadism 11.57 10.75 6 154041 97 46531918
Tympanic membrane disorder 11.54 10.75 7 154040 155 46531860
Hepatic infarction 11.54 10.75 12 154035 592 46531423
Astrocytoma, low grade 11.51 10.75 5 154042 53 46531962
Blood loss anaemia 11.47 10.75 7 154040 8550 46523465
Cranial nerve disorder 11.47 10.75 9 154038 306 46531709
Cushingoid 11.46 10.75 46 154001 6220 46525795
Crohn's disease 11.46 10.75 4 154043 6767 46525248
Cutaneous T-cell lymphoma 11.46 10.75 18 154029 1345 46530670
Drug ineffective for unapproved indication 11.45 10.75 93 153954 16320 46515695
Culture stool positive 11.44 10.75 9 154038 307 46531708
Vascular injury 11.39 10.75 14 154033 830 46531185
Flagellate dermatitis 11.38 10.75 7 154040 159 46531856
Urethritis 11.35 10.75 8 154039 230 46531785
Scintillating scotoma 11.34 10.75 7 154040 160 46531855
Hodgkin's disease 11.34 10.75 14 154033 834 46531181
Liver function test increased 11.33 10.75 38 154009 22788 46509227
Rotavirus infection 11.32 10.75 8 154039 231 46531784
Pulmonary haemosiderosis 11.31 10.75 4 154043 23 46531992
Artificial menopause 11.31 10.75 4 154043 23 46531992
Skin abrasion 11.30 10.75 7 154040 8481 46523534
Encopresis 11.25 10.75 6 154041 103 46531912
Pulmonary vascular disorder 11.24 10.75 9 154038 315 46531700
Vitamin D decreased 11.24 10.75 6 154041 7887 46524128
Blister rupture 11.23 10.75 8 154039 234 46531781
Coronavirus infection 11.23 10.75 27 154020 2767 46529248
Blood creatine increased 11.20 10.75 37 154010 4553 46527462
Blood glucose abnormal 11.19 10.75 4 154043 6668 46525347
Pleocytosis 11.19 10.75 11 154036 507 46531508
Intracardiac thrombus 11.17 10.75 24 154023 2284 46529731
Brain oedema 11.16 10.75 75 153972 12403 46519612
Blood immunoglobulin A decreased 11.12 10.75 9 154038 320 46531695
Strongyloidiasis 11.12 10.75 14 154033 851 46531164
Human T-cell lymphotropic virus type I infection 11.11 10.75 5 154042 58 46531957
Palatal ulcer 11.11 10.75 5 154042 58 46531957
Antineutrophil cytoplasmic antibody increased 11.11 10.75 5 154042 58 46531957
Papillary thyroid cancer 11.08 10.75 22 154025 1979 46530036
Kaposi's sarcoma 11.08 10.75 7 154040 167 46531848
Blister 11.07 10.75 94 153953 44537 46487478
Peripheral vascular disorder 11.07 10.75 3 154044 5974 46526041
Anti-platelet antibody positive 11.03 10.75 5 154042 59 46531956
Metastases to heart 11.03 10.75 5 154042 59 46531956
Ocular lymphoma 11.03 10.75 5 154042 59 46531956
Leukaemic infiltration extramedullary 11.03 10.75 5 154042 59 46531956
Urinary bladder sarcoma 11.03 10.75 4 154043 25 46531990
Thirst 10.96 10.75 12 154035 10964 46521051
Disease risk factor 10.96 10.75 5 154042 60 46531955
Tumour haemorrhage 10.96 10.75 18 154029 1397 46530618
Mucocutaneous leishmaniasis 10.93 10.75 9 154038 328 46531687
Device malfunction 10.92 10.75 17 154030 13357 46518658
Genital haemorrhage 10.91 10.75 4 154043 6562 46525453
Paraneoplastic syndrome 10.91 10.75 11 154036 523 46531492
Viral sepsis 10.90 10.75 4 154043 26 46531989
Reversible cerebral vasoconstriction syndrome 10.89 10.75 20 154027 1697 46530318
Pseudomembranous colitis 10.89 10.75 29 154018 3166 46528849
Normochromic anaemia 10.89 10.75 8 154039 246 46531769
Blood gonadotrophin increased 10.88 10.75 3 154044 6 46532009
Adenoviral encephalitis 10.88 10.75 3 154044 6 46532009
Pericardial cyst 10.88 10.75 3 154044 6 46532009
Adult T-cell lymphoma/leukaemia recurrent 10.88 10.75 3 154044 6 46532009
Ovarian epithelial cancer stage III 10.88 10.75 3 154044 6 46532009
Areflexia 10.88 10.75 28 154019 2995 46529020
Pneumonia parainfluenzae viral 10.82 10.75 5 154042 62 46531953
Stress fracture 10.78 10.75 5 154042 7122 46524893
Product use issue 10.78 10.75 234 153813 94410 46437605
Blood thyroid stimulating hormone increased 10.77 10.75 3 154044 5866 46526149
Lacrimal haemorrhage 10.77 10.75 4 154043 27 46531988
Transplant dysfunction 10.77 10.75 37 154010 4645 46527370
Immunodeficiency common variable 10.75 10.75 6 154041 113 46531902

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 3338.22 12.03 3091 123478 103602 29722307
Product use in unapproved indication 1312.05 12.03 1585 124984 72108 29753801
Neutropenia 1307.65 12.03 2111 124458 126429 29699480
Cytokine release syndrome 1036.48 12.03 599 125970 9334 29816575
Acute graft versus host disease 746.28 12.03 403 126166 5461 29820448
Bone marrow failure 721.45 12.03 753 125816 29032 29796877
Mucosal inflammation 719.14 12.03 760 125809 29734 29796175
Myelodysplastic syndrome 692.24 12.03 599 125970 18179 29807730
Hepatitis B 689.32 12.03 387 126182 5685 29820224
Cytomegalovirus infection 682.71 12.03 658 125911 23016 29802893
Off label use 635.23 12.03 2398 124171 246892 29579017
Hypogammaglobulinaemia 599.60 12.03 336 126233 4916 29820993
Progressive multifocal leukoencephalopathy 591.06 12.03 405 126164 8608 29817301
Diffuse large B-cell lymphoma 573.35 12.03 377 126192 7464 29818445
Cystitis haemorrhagic 570.40 12.03 315 126254 4472 29821437
Haematotoxicity 521.39 12.03 325 126244 5845 29820064
Diffuse large B-cell lymphoma recurrent 505.84 12.03 223 126346 1869 29824040
Graft versus host disease 503.27 12.03 385 126184 9765 29816144
Chronic graft versus host disease 501.66 12.03 275 126294 3844 29822065
Second primary malignancy 497.60 12.03 319 126250 6037 29819872
Acute myeloid leukaemia 482.69 12.03 481 126088 17525 29808384
Venoocclusive liver disease 457.02 12.03 307 126262 6306 29819603
Pyrexia 434.79 12.03 2413 124156 292076 29533833
Acute graft versus host disease in skin 430.58 12.03 257 126312 4259 29821650
Cytopenia 424.39 12.03 320 126249 7936 29817973
Pancytopenia 423.08 12.03 1037 125532 84015 29741894
Completed suicide 393.94 12.03 5 126564 99487 29726422
Pneumocystis jirovecii pneumonia 375.77 12.03 411 126158 16709 29809200
Hepatitis B reactivation 361.21 12.03 196 126373 2681 29823228
Myelosuppression 354.79 12.03 274 126295 7048 29818861
Posterior reversible encephalopathy syndrome 349.91 12.03 292 126277 8415 29817494
Fall 348.04 12.03 167 126402 181705 29644204
Neutrophil count decreased 347.88 12.03 635 125934 41819 29784090
Neurotoxicity 341.97 12.03 346 126223 12836 29813073
Venoocclusive disease 340.69 12.03 182 126387 2408 29823501
Febrile bone marrow aplasia 332.57 12.03 275 126294 7822 29818087
Tumour lysis syndrome 310.38 12.03 325 126244 12560 29813349
Thrombocytopenia 302.81 12.03 1263 125306 135781 29690128
Adenovirus infection 301.78 12.03 201 126368 4067 29821842
Epstein-Barr virus infection 301.27 12.03 240 126329 6466 29819443
Neutropenic sepsis 273.42 12.03 287 126282 11122 29814787
Acute lymphocytic leukaemia recurrent 267.91 12.03 157 126412 2510 29823399
Leukopenia 262.41 12.03 669 125900 55490 29770419
Myocardial infarction 259.68 12.03 103 126466 125522 29700387
Product dose omission issue 259.16 12.03 39 126530 91592 29734317
Drug interaction 255.86 12.03 280 126289 199288 29626621
Dizziness 249.26 12.03 274 126295 194635 29631274
Post transplant lymphoproliferative disorder 240.71 12.03 191 126378 5115 29820794
Disease progression 237.49 12.03 810 125759 79064 29746845
Sepsis 232.70 12.03 1226 125343 145169 29680740
Plasma cell myeloma 226.42 12.03 614 125955 52848 29773061
White blood cell count decreased 226.08 12.03 824 125745 83123 29742786
Arthralgia 225.97 12.03 148 126421 135643 29690266
Haemophagocytic lymphohistiocytosis 221.69 12.03 239 126330 9552 29816357
Overdose 216.58 12.03 46 126523 84291 29741618
Aspergillus infection 213.37 12.03 239 126330 9975 29815934
Fatigue 211.50 12.03 675 125894 319998 29505911
Graft versus host disease in skin 208.27 12.03 145 126424 3162 29822747
Disease recurrence 205.96 12.03 276 126293 13885 29812024
Cardiotoxicity 204.76 12.03 161 126408 4253 29821656
Lymphopenia 204.50 12.03 265 126304 12898 29813011
Pain 203.19 12.03 259 126310 172382 29653527
Graft versus host disease in gastrointestinal tract 194.30 12.03 135 126434 2934 29822975
BK virus infection 193.49 12.03 155 126414 4209 29821700
Anxiety 190.08 12.03 71 126498 89800 29736109
Septic shock 188.07 12.03 644 125925 62963 29762946
Rhabdomyolysis 179.86 12.03 27 126542 63553 29762356
Malaise 179.85 12.03 267 126302 166695 29659214
Acquired gene mutation 179.69 12.03 91 126478 1070 29824839
Thrombotic microangiopathy 177.33 12.03 200 126369 8410 29817499
Platelet count decreased 171.31 12.03 893 125676 105236 29720673
Cytomegalovirus chorioretinitis 170.88 12.03 128 126441 3140 29822769
Bronchopulmonary aspergillosis 170.41 12.03 234 126335 12050 29813859
Insomnia 170.32 12.03 91 126478 93245 29732664
Diffuse large B-cell lymphoma refractory 169.24 12.03 77 126492 700 29825209
Therapy partial responder 165.57 12.03 132 126437 3559 29822350
Dyspnoea 164.33 12.03 788 125781 332507 29493402
Multiple organ dysfunction syndrome 161.47 12.03 612 125957 62875 29763034
Death 159.62 12.03 874 125695 356409 29469500
Rash 157.72 12.03 362 126207 191527 29634382
Depression 152.48 12.03 97 126472 90340 29735569
Neoplasm progression 150.56 12.03 272 126297 17751 29808158
Malignant neoplasm progression 149.06 12.03 653 125916 71634 29754275
Acute lymphocytic leukaemia 148.89 12.03 115 126454 2957 29822952
Acute graft versus host disease in intestine 145.75 12.03 103 126466 2302 29823607
B-cell lymphoma recurrent 144.10 12.03 65 126504 578 29825331
Lymphadenopathy 142.53 12.03 317 126252 24059 29801850
Blood pressure increased 140.46 12.03 64 126505 71864 29754045
Suicide attempt 136.53 12.03 4 126565 36693 29789216
Pruritus 136.18 12.03 180 126389 118024 29707885
Cerebrovascular accident 129.49 12.03 98 126471 83379 29742530
Blood glucose increased 129.41 12.03 49 126520 61481 29764428
Muscle spasms 129.26 12.03 56 126513 64782 29761127
Infection 128.69 12.03 661 125908 77413 29748496
Feeling abnormal 128.35 12.03 40 126529 56716 29769193
Somnolence 127.95 12.03 132 126437 96631 29729278
Psoriasis 127.48 12.03 15 126554 42491 29783418
Suicidal ideation 127.27 12.03 6 126563 36108 29789801
Lymphocyte count decreased 125.41 12.03 260 126309 18795 29807114
B-cell type acute leukaemia 125.16 12.03 47 126522 246 29825663
Neuropathy peripheral 124.86 12.03 609 125960 69866 29756043
Coronary artery disease 121.81 12.03 30 126539 49682 29776227
Gait disturbance 120.91 12.03 84 126485 74693 29751216
Chest pain 119.95 12.03 195 126374 117432 29708477
Cytomegalovirus infection reactivation 119.38 12.03 80 126489 1635 29824274
Epstein-Barr virus associated lymphoproliferative disorder 118.83 12.03 80 126489 1648 29824261
Mantle cell lymphoma recurrent 118.36 12.03 50 126519 373 29825536
Herpes simplex 117.25 12.03 118 126451 4346 29821563
JC virus infection 116.28 12.03 80 126489 1710 29824199
Aggression 115.87 12.03 11 126558 36896 29789013
Stem cell transplant 114.84 12.03 85 126484 2046 29823863
Joint swelling 113.73 12.03 29 126540 46917 29778992
Central nervous system lymphoma 113.38 12.03 61 126508 819 29825090
Pain in extremity 113.06 12.03 182 126387 110039 29715870
Headache 112.07 12.03 395 126174 181911 29643998
Inappropriate schedule of product administration 112.04 12.03 17 126552 39711 29786198
Chronic lymphocytic leukaemia 111.89 12.03 117 126452 4511 29821398
Sweat gland tumour 111.30 12.03 48 126521 379 29825530
Myalgia 110.20 12.03 97 126472 76570 29749339
Hypoglycaemia 109.90 12.03 39 126530 50942 29774967
Loss of consciousness 109.84 12.03 104 126465 79271 29746638
Respiratory failure 109.30 12.03 764 125805 99878 29726031
Neoplasm recurrence 108.62 12.03 78 126491 1789 29824120
Hallucination 108.40 12.03 36 126533 49023 29776886
Asthenia 107.13 12.03 526 126043 220764 29605145
Peripheral swelling 106.39 12.03 63 126506 61011 29764898
Autoimmune haemolytic anaemia 106.07 12.03 107 126462 3952 29821957
Drug resistance 104.66 12.03 250 126319 19883 29806026
Intentional product misuse 104.54 12.03 12 126557 34655 29791254
Systemic mycosis 102.57 12.03 64 126505 1152 29824757
Toxicity to various agents 101.62 12.03 395 126174 176788 29649121
Aplasia 97.49 12.03 102 126467 3935 29821974
Rheumatoid arthritis 96.85 12.03 27 126542 41170 29784739
Immune effector cell-associated neurotoxicity syndrome 95.61 12.03 54 126515 802 29825107
Human herpesvirus 6 infection 94.24 12.03 73 126496 1885 29824024
Chronic lymphocytic leukaemia recurrent 94.12 12.03 43 126526 395 29825514
Candida infection 93.44 12.03 203 126366 15159 29810750
Cytomegalovirus viraemia 93.15 12.03 118 126451 5611 29820298
Chronic graft versus host disease in skin 93.02 12.03 50 126519 670 29825239
Fungal infection 92.35 12.03 188 126381 13412 29812497
B-cell lymphoma 91.57 12.03 104 126465 4406 29821503
Hospitalisation 90.37 12.03 37 126532 44282 29781627
Viral haemorrhagic cystitis 89.95 12.03 52 126517 809 29825100
Drug hypersensitivity 88.82 12.03 95 126474 68424 29757485
Transplant failure 88.42 12.03 78 126491 2426 29823483
Weight increased 88.35 12.03 112 126457 74801 29751108
Lymphoproliferative disorder 87.15 12.03 75 126494 2255 29823654
Hyperhidrosis 86.98 12.03 93 126476 66997 29758912
Cardiac failure congestive 86.88 12.03 139 126430 84268 29741641
Chronic obstructive pulmonary disease 85.52 12.03 44 126525 46082 29779827
Nausea 85.44 12.03 823 125746 296134 29529775
Plasmacytoma 85.02 12.03 87 126482 3269 29822640
Pneumonia cytomegaloviral 84.85 12.03 80 126489 2716 29823193
Bacterial sepsis 84.15 12.03 104 126465 4822 29821087
Acute graft versus host disease in liver 83.72 12.03 57 126512 1197 29824712
Injection site pain 83.14 12.03 14 126555 30296 29795613
Cystitis viral 82.34 12.03 40 126529 427 29825482
Polyneuropathy 82.14 12.03 165 126404 11658 29814251
Weight decreased 81.74 12.03 344 126225 150577 29675332
Mucormycosis 81.71 12.03 106 126463 5162 29820747
Cytomegalovirus test positive 80.79 12.03 88 126481 3557 29822352
Escherichia infection 79.92 12.03 116 126453 6289 29819620
Musculoskeletal stiffness 79.84 12.03 26 126543 35855 29790054
Minimal residual disease 79.47 12.03 32 126537 208 29825701
Engraftment syndrome 78.34 12.03 47 126522 786 29825123
Blood creatine phosphokinase increased 78.11 12.03 44 126525 43804 29782105
Nasopharyngitis 76.93 12.03 81 126488 58768 29767141
Bacteraemia 76.37 12.03 189 126380 15371 29810538
Hepatic failure 75.86 12.03 315 126254 33728 29792181
Hyperkalaemia 74.45 12.03 102 126467 65908 29760001
International normalised ratio increased 72.77 12.03 57 126512 47682 29778227
Escherichia sepsis 72.57 12.03 87 126482 3907 29822002
Leukaemia recurrent 72.53 12.03 57 126512 1504 29824405
Stress 72.48 12.03 3 126566 20232 29805677
Therapy non-responder 72.40 12.03 281 126288 29172 29796737
Abdominal discomfort 72.20 12.03 60 126509 48731 29777178
Wrong technique in product usage process 72.15 12.03 21 126548 31134 29794775
Back pain 71.51 12.03 210 126359 102386 29723523
Bradycardia 71.17 12.03 104 126465 65422 29760487
Microsporidia infection 69.89 12.03 39 126530 565 29825344
Plasma cell myeloma recurrent 69.77 12.03 79 126490 3335 29822574
Leukoencephalopathy 69.18 12.03 85 126484 3917 29821992
Diarrhoea 69.01 12.03 996 125573 333107 29492802
Chest discomfort 68.45 12.03 55 126514 45425 29780484
Lymphoma 67.64 12.03 139 126430 9982 29815927
Incorrect dose administered 66.99 12.03 25 126544 31661 29794248
Confusional state 66.57 12.03 318 126251 134516 29691393
Syncope 65.76 12.03 165 126404 84738 29741171
Urticaria 65.04 12.03 81 126488 54525 29771384
Cytogenetic abnormality 64.99 12.03 41 126528 753 29825156
Pseudomonas infection 64.30 12.03 139 126430 10343 29815566
Agranulocytosis 62.87 12.03 220 126349 21722 29804187
Blood stem cell transplant failure 61.97 12.03 32 126537 393 29825516
Injury 61.95 12.03 9 126560 21722 29804187
Osteoarthritis 61.70 12.03 4 126565 18345 29807564
Stomatitis 61.61 12.03 316 126253 36963 29788946
Klebsiella infection 61.44 12.03 107 126462 6780 29819129
Loss of personal independence in daily activities 61.20 12.03 9 126560 21526 29804383
Osteonecrosis 61.04 12.03 178 126391 15957 29809952
Product quality issue 60.53 12.03 5 126564 18769 29807140
Abnormal behaviour 59.83 12.03 17 126552 25606 29800303
Agitation 59.52 12.03 85 126484 53988 29771921
Contusion 59.23 12.03 29 126540 31251 29794658
Refractory cytopenia with multilineage dysplasia 59.08 12.03 23 126546 135 29825774
Graft versus host disease in liver 58.61 12.03 42 126527 960 29824949
Enterococcal infection 58.60 12.03 116 126453 8108 29817801
Interstitial lung disease 58.39 12.03 445 126124 59752 29766157
Staphylococcal sepsis 58.38 12.03 126 126443 9365 29816544
Cerebral toxoplasmosis 58.37 12.03 49 126520 1423 29824486
Pneumonia 58.35 12.03 1835 124734 332471 29493438
Refractory anaemia with an excess of blasts 58.27 12.03 30 126539 366 29825543
Asthma 57.96 12.03 41 126528 36133 29789776
Sedation 56.79 12.03 3 126566 16370 29809539
Pulmonary toxicity 56.65 12.03 82 126487 4434 29821475
Fusarium infection 56.35 12.03 42 126527 1022 29824887
Skin toxicity 56.15 12.03 69 126500 3180 29822729
Pneumonia fungal 56.06 12.03 91 126478 5442 29820467
Anaplastic lymphoma kinase gene mutation 56.06 12.03 20 126549 88 29825821
Accidental overdose 55.91 12.03 6 126563 18269 29807640
Pseudomonal sepsis 55.58 12.03 66 126503 2934 29822975
Dehydration 55.49 12.03 301 126268 123238 29702671
Angioedema 55.05 12.03 39 126530 34345 29791564
Bone marrow transplant rejection 54.62 12.03 23 126546 170 29825739
Hypersensitivity 54.60 12.03 90 126479 53938 29771971
Electrocardiogram QT prolonged 54.34 12.03 43 126526 35792 29790117
Malignant transformation 53.85 12.03 35 126534 678 29825231
Arthropathy 53.79 12.03 11 126558 20716 29805193
Abdominal pain upper 53.70 12.03 115 126454 62436 29763473
Bacterial infection 53.47 12.03 145 126424 12465 29813444
End stage renal disease 53.13 12.03 105 126464 7330 29818579
Psychotic disorder 52.65 12.03 13 126556 21502 29804407
Balance disorder 52.61 12.03 46 126523 36447 29789462
Cardiac arrest 52.49 12.03 208 126361 92642 29733267
Enterovirus infection 52.27 12.03 32 126537 556 29825353
Tremor 51.95 12.03 155 126414 75208 29750701
Decreased appetite 51.65 12.03 396 126173 149514 29676395
Hepatotoxicity 51.18 12.03 181 126388 17964 29807945
Azoospermia 50.89 12.03 28 126541 394 29825515
Lung infiltration 50.86 12.03 142 126427 12417 29813492
Heart rate decreased 50.77 12.03 13 126556 20981 29804928
Neuroblastoma 50.37 12.03 23 126546 211 29825698
Myelopathy 50.28 12.03 51 126518 1896 29824013
Plasmablastic lymphoma 50.25 12.03 24 126545 246 29825663
Plasma cell leukaemia 50.08 12.03 37 126532 888 29825021
Drug dependence 49.96 12.03 14 126555 21281 29804628
Pneumocystis jirovecii infection 49.71 12.03 43 126526 1302 29824607
Chronic graft versus host disease in liver 49.59 12.03 24 126545 254 29825655
Lactic acidosis 49.19 12.03 36 126533 31177 29794732
Infection reactivation 49.13 12.03 37 126532 915 29824994
Pneumonitis 49.09 12.03 238 126331 27216 29798693
Nephropathy toxic 48.84 12.03 126 126443 10513 29815396
Respiratory arrest 48.42 12.03 32 126537 29226 29796683
Unevaluable event 48.37 12.03 38 126531 31747 29794162
Mobility decreased 47.88 12.03 25 126544 25974 29799935
Cardio-respiratory arrest 47.84 12.03 107 126462 57199 29768710
Cardiac disorder 47.68 12.03 59 126510 39834 29786075
Peripheral T-cell lymphoma unspecified 47.66 12.03 29 126540 498 29825411
Product prescribing error 47.54 12.03 7 126562 16726 29809183
Sleep disorder 47.41 12.03 22 126547 24457 29801452
Central nervous system fungal infection 47.31 12.03 23 126546 246 29825663
Primary hypogonadism 47.26 12.03 17 126552 77 29825832
Capillary leak syndrome 47.25 12.03 46 126523 1626 29824283
Candida sepsis 46.53 12.03 38 126531 1061 29824848
Clostridium difficile colitis 46.53 12.03 139 126430 12629 29813280
Flushing 46.49 12.03 34 126535 29458 29796451
Neutropenic colitis 46.25 12.03 52 126517 2178 29823731
Drug ineffective for unapproved indication 46.03 12.03 125 126444 10755 29815154
Epstein-Barr viraemia 45.94 12.03 35 126534 881 29825028
Strongyloidiasis 45.77 12.03 53 126516 2293 29823616
Heart rate increased 45.51 12.03 58 126511 38663 29787246
Dry skin 45.35 12.03 19 126550 22435 29803474
Rhinovirus infection 44.51 12.03 58 126511 2837 29823072
Recurrent cancer 44.28 12.03 38 126531 1138 29824771
Restlessness 44.25 12.03 20 126549 22579 29803330
Head injury 44.23 12.03 9 126560 17011 29808898
Nephrolithiasis 44.03 12.03 25 126544 24785 29801124
Treatment noncompliance 44.02 12.03 26 126543 25227 29800682
Nocardiosis 43.72 12.03 63 126506 3392 29822517
Staphylococcal bacteraemia 42.95 12.03 91 126478 6677 29819232
Herpes zoster 42.82 12.03 244 126325 29699 29796210
Klebsiella sepsis 42.57 12.03 44 126525 1673 29824236
Road traffic accident 42.39 12.03 10 126559 17061 29808848
Memory impairment 42.34 12.03 57 126512 37117 29788792
Wheezing 42.22 12.03 41 126528 30897 29795012
Acute kidney injury 41.97 12.03 861 125708 272981 29552928
Pneumonia klebsiella 41.56 12.03 53 126516 2537 29823372
Treatment failure 40.99 12.03 269 126300 34410 29791499
Erythema 40.96 12.03 178 126391 77273 29748636
Peripheral sensory neuropathy 40.56 12.03 82 126487 5819 29820090
Pulmonary vascular disorder 40.46 12.03 23 126546 346 29825563
Gene mutation 40.36 12.03 31 126538 790 29825119
Guillain-Barre syndrome 40.27 12.03 75 126494 5008 29820901
Heart rate irregular 40.27 12.03 3 126566 12256 29813653
Bone marrow necrosis 39.77 12.03 17 126552 131 29825778
Blood fibrinogen decreased 39.37 12.03 33 126536 956 29824953
Respiratory tract infection fungal 39.26 12.03 28 126541 635 29825274
Clostridium difficile infection 39.11 12.03 151 126418 15632 29810277
Intentional product use issue 39.10 12.03 276 126293 36164 29789745
Myelitis transverse 39.06 12.03 33 126536 967 29824942
Gastrointestinal haemorrhage 38.73 12.03 201 126368 83245 29742664
Drug reaction with eosinophilia and systemic symptoms 38.59 12.03 38 126531 28450 29797459
Depressed mood 38.48 12.03 12 126557 17017 29808892
Cardiomyopathy 38.45 12.03 146 126423 14997 29810912
Nervousness 38.39 12.03 3 126566 11785 29814124
Blood pressure fluctuation 38.38 12.03 13 126556 17490 29808419
Colitis 38.23 12.03 242 126327 30578 29795331
5q minus syndrome 38.19 12.03 17 126552 146 29825763
Encephalopathy 38.18 12.03 250 126319 31955 29793954
Oedema peripheral 38.12 12.03 276 126293 105556 29720353
Diffuse large B-cell lymphoma stage IV 37.84 12.03 19 126550 219 29825690
Psoriatic arthropathy 37.65 12.03 10 126559 15751 29810158
Lymphoma transformation 37.60 12.03 17 126552 152 29825757
Peritonitis pneumococcal 37.52 12.03 11 126558 21 29825888
Bone marrow infiltration 37.32 12.03 15 126554 97 29825812
Gastrooesophageal reflux disease 37.20 12.03 49 126520 32206 29793703
Irritability 37.08 12.03 26 126543 23024 29802885
Faeces discoloured 37.03 12.03 7 126562 13939 29811970
Autoimmune neutropenia 37.01 12.03 20 126549 271 29825638
Encephalitis 36.82 12.03 83 126486 6353 29819556
Device related infection 36.76 12.03 156 126413 16859 29809050
Adenoviral haemorrhagic cystitis 36.71 12.03 23 126546 417 29825492
Acute lymphocytic leukaemia refractory 36.68 12.03 15 126554 102 29825807
Delusion 36.52 12.03 4 126565 11985 29813924
Swelling 36.27 12.03 60 126509 35915 29789994
Traumatic lung injury 36.23 12.03 34 126535 1147 29824762
Acute myelomonocytic leukaemia 36.19 12.03 16 126553 135 29825774
Human herpesvirus 8 infection 36.05 12.03 27 126542 662 29825247
Varicella zoster virus infection 36.05 12.03 35 126534 1233 29824676
Complications of bone marrow transplant 35.96 12.03 18 126551 206 29825703
Blood glucose decreased 35.86 12.03 6 126563 13047 29812862
Obliterative bronchiolitis 35.82 12.03 34 126535 1164 29824745
Emotional distress 35.82 12.03 11 126558 15754 29810155
Palpitations 35.74 12.03 54 126515 33519 29792390
Liver function test abnormal 35.71 12.03 47 126522 30903 29795006
Musculoskeletal pain 35.69 12.03 47 126522 30893 29795016
Gastritis bacterial 35.62 12.03 17 126552 174 29825735
B-cell lymphoma refractory 35.61 12.03 15 126554 111 29825798
Thymus enlargement 35.60 12.03 13 126556 62 29825847
Human polyomavirus infection 35.19 12.03 26 126543 624 29825285
Encephalitis enteroviral 34.92 12.03 16 126553 148 29825761
Transient ischaemic attack 34.85 12.03 33 126536 25167 29800742
Amyloidosis 34.68 12.03 44 126525 2095 29823814
Amnesia 34.64 12.03 31 126538 24290 29801619
Dyskinesia 34.64 12.03 25 126544 21809 29804100
Injection site erythema 34.56 12.03 8 126561 13826 29812083
Vertigo 34.52 12.03 27 126542 22608 29803301
Nightmare 34.42 12.03 5 126564 12071 29813838
Myocardial ischaemia 34.42 12.03 15 126554 17302 29808607
Systemic candida 34.39 12.03 50 126519 2714 29823195
Aphasia 34.38 12.03 168 126401 19271 29806638
Swollen tongue 34.23 12.03 7 126562 13185 29812724
Prostatic specific antigen increased 34.15 12.03 5 126564 11999 29813910
Chronic lymphocytic leukaemia refractory 34.14 12.03 14 126555 96 29825813
Chloroma 33.95 12.03 22 126547 424 29825485
Dysgeusia 33.69 12.03 33 126536 24768 29801141
Nasal cavity cancer 33.68 12.03 15 126554 129 29825780
Staphylococcal infection 33.65 12.03 231 126338 29993 29795916
Engraft failure 33.63 12.03 22 126547 431 29825478
Paraparesis 33.46 12.03 40 126529 1791 29824118
Graft versus host disease in eye 33.34 12.03 17 126552 203 29825706
Disseminated intravascular coagulation 33.24 12.03 183 126386 21988 29803921
Out of specification test results 33.17 12.03 10 126559 22 29825887
Parainfluenzae virus infection 33.17 12.03 42 126527 1996 29823913
Herpes virus infection 33.09 12.03 47 126522 2497 29823412
B-cell aplasia 33.07 12.03 12 126557 56 29825853
Dyspepsia 33.05 12.03 48 126521 30281 29795628
Colitis ulcerative 32.92 12.03 10 126559 14424 29811485
Acute myocardial infarction 32.90 12.03 114 126455 52825 29773084
Haematocrit decreased 32.63 12.03 232 126337 30467 29795442
Adverse event 32.60 12.03 12 126557 15329 29810580
Congenital cardiovascular anomaly 32.28 12.03 16 126553 179 29825730
Neutropenic infection 32.27 12.03 30 126539 1000 29824909
Multiple sclerosis relapse 32.15 12.03 4 126565 10858 29815051
B-lymphocyte count decreased 32.06 12.03 22 126547 468 29825441
Fear 32.00 12.03 4 126565 10821 29815088
H1N1 influenza 32.00 12.03 29 126540 935 29824974
Therapeutic response decreased 31.96 12.03 194 126375 24155 29801754
Pleural effusion 31.77 12.03 464 126105 73602 29752307
Granulomatosis with polyangiitis 31.68 12.03 28 126541 873 29825036
High-grade B-cell lymphoma 31.64 12.03 15 126554 151 29825758
Dry mouth 31.51 12.03 30 126539 22820 29803089
Chronic lymphocytic leukaemia transformation 31.38 12.03 16 126553 191 29825718
Ependymoma 31.32 12.03 12 126557 67 29825842
Metabolic acidosis 31.21 12.03 70 126499 37391 29788518
Chronic myeloid leukaemia 31.17 12.03 46 126523 2531 29823378
Acute promyelocytic leukaemia 31.09 12.03 23 126546 553 29825356
Respiratory tract infection 31.08 12.03 139 126430 15367 29810542
Meningoencephalitis herpetic 31.06 12.03 26 126543 752 29825157
Herpes simplex encephalitis 31.03 12.03 18 126551 282 29825627
Medication error 30.75 12.03 26 126543 20946 29804963
Respirovirus test positive 30.73 12.03 11 126558 49 29825860
Unresponsive to stimuli 30.60 12.03 40 126529 26379 29799530
Viral sinusitis 30.55 12.03 11 126558 50 29825859
T-cell lymphoma 30.48 12.03 28 126541 919 29824990
Influenza like illness 30.46 12.03 38 126531 25567 29800342
Blindness cortical 30.42 12.03 18 126551 293 29825616
Hallucination, visual 30.41 12.03 15 126554 16098 29809811
Mantle cell lymphoma 30.38 12.03 35 126534 1506 29824403
Hot flush 30.33 12.03 12 126557 14668 29811241
Primitive neuroectodermal tumour 30.33 12.03 12 126557 74 29825835
B-lymphocyte count abnormal 30.26 12.03 8 126561 8 29825901
Surgery 30.24 12.03 6 126563 11545 29814364
Abdominal distension 30.07 12.03 96 126473 45613 29780296
Bone marrow disorder 30.01 12.03 34 126535 1436 29824473
Myeloid leukaemia 29.97 12.03 19 126550 352 29825557
Flatulence 29.76 12.03 20 126549 18109 29807800
Haemoglobin abnormal 29.73 12.03 50 126519 3079 29822830
Therapy responder 29.72 12.03 15 126554 175 29825734
T-cell lymphoma stage IV 29.70 12.03 14 126555 139 29825770
Paranoia 29.55 12.03 4 126565 10184 29815725
Vision blurred 29.53 12.03 85 126484 41731 29784178
Molluscum contagiosum 29.49 12.03 17 126552 263 29825646
Febrile infection 29.46 12.03 36 126533 1649 29824260
Constipation 29.39 12.03 320 126249 112586 29713323
Hyperlipidaemia 29.34 12.03 11 126558 13896 29812013
Haematochezia 29.29 12.03 63 126506 34159 29791750
Pneumomediastinum 29.29 12.03 37 126532 1754 29824155
Osteosarcoma 29.28 12.03 15 126554 181 29825728
Acute erythroid leukaemia 28.94 12.03 14 126555 148 29825761
Therapeutic product effect decreased 28.84 12.03 49 126520 29027 29796882
Therapy cessation 28.70 12.03 14 126555 15123 29810786
Hepatic infection fungal 28.69 12.03 14 126555 151 29825758
Salivary gland cancer 28.66 12.03 16 126553 232 29825677
Hepatosplenomegaly 28.56 12.03 54 126515 3647 29822262
Autoimmune lymphoproliferative syndrome 28.53 12.03 14 126555 153 29825756
Encephalitis viral 28.40 12.03 30 126539 1170 29824739
Refractory cancer 28.40 12.03 13 126556 120 29825789
Delirium 28.39 12.03 83 126486 40548 29785361
Type 2 diabetes mellitus 28.37 12.03 11 126558 13611 29812298
Peripheral motor neuropathy 28.29 12.03 35 126534 1624 29824285
Stenotrophomonas sepsis 28.13 12.03 12 126557 92 29825817
Pulmonary arteriopathy 28.05 12.03 11 126558 66 29825843
West Nile viral infection 28.04 12.03 22 126547 579 29825330
Synovitis 28.00 12.03 4 126565 9779 29816130
Hepatosplenic candidiasis 27.84 12.03 15 126554 202 29825707
Ventricular tachycardia 27.77 12.03 36 126533 23826 29802083
Central nervous system leukaemia 27.73 12.03 16 126553 248 29825661
Gastrosplenic fistula 27.63 12.03 9 126560 28 29825881
Adult T-cell lymphoma/leukaemia 27.62 12.03 16 126553 250 29825659
Haematopoietic stem cell mobilisation 27.61 12.03 14 126555 165 29825744
Epstein-Barr virus associated lymphoma 27.55 12.03 21 126548 529 29825380
Eczema 27.50 12.03 11 126558 13358 29812551
Acute monocytic leukaemia 27.50 12.03 18 126551 353 29825556
Hypertriglyceridaemia 27.48 12.03 86 126483 8012 29817897
Aspiration bone marrow abnormal 27.37 12.03 12 126557 99 29825810
Coma 27.28 12.03 84 126485 40365 29785544
Skin laceration 27.14 12.03 7 126562 11244 29814665
Blood pressure systolic increased 27.13 12.03 15 126554 15095 29810814
Diabetic ketoacidosis 27.11 12.03 17 126552 15969 29809940
Pneumonia viral 27.08 12.03 44 126525 2633 29823276
Clear cell renal cell carcinoma 27.04 12.03 26 126543 905 29825004
Paresis 26.98 12.03 36 126533 1802 29824107
Neurofibrosarcoma 26.94 12.03 9 126560 31 29825878
Hypoxia 26.89 12.03 315 126254 47539 29778370
Acute myeloid leukaemia recurrent 26.88 12.03 33 126536 1519 29824390
Enterovesical fistula 26.85 12.03 22 126547 617 29825292
Cytomegalovirus colitis 26.69 12.03 41 126528 2338 29823571
Gallbladder oedema 26.28 12.03 14 126555 184 29825725
Cholelithiasis 26.23 12.03 28 126541 20197 29805712
Hernia 26.20 12.03 3 126566 8683 29817226
Neck pain 26.06 12.03 30 126539 20914 29804995
Gastrointestinal toxicity 25.98 12.03 37 126532 1971 29823938
Pneumonia adenoviral 25.88 12.03 13 126556 150 29825759
Hypersomnia 25.52 12.03 8 126561 11308 29814601
Oxygen saturation decreased 25.37 12.03 96 126473 43344 29782565
Cerebral aspergillosis 25.36 12.03 30 126539 1328 29824581
Lymphoplasmacytoid lymphoma/immunocytoma 25.34 12.03 9 126560 39 29825870
Nervous system disorder 25.33 12.03 116 126453 12953 29812956
Metastasis 25.30 12.03 48 126521 3250 29822659
Anti-neutrophil cytoplasmic antibody positive vasculitis 25.24 12.03 21 126548 602 29825307
Human metapneumovirus test positive 25.23 12.03 10 126559 62 29825847
Skin discolouration 25.16 12.03 18 126551 15776 29810133
Extrapyramidal disorder 25.14 12.03 7 126562 10686 29815223
Neutrophil count abnormal 25.06 12.03 30 126539 1345 29824564
Blood urea increased 25.04 12.03 60 126509 31321 29794588
Sinusitis bacterial 25.03 12.03 16 126553 301 29825608
Enterococcal sepsis 25.02 12.03 32 126537 1536 29824373
Neuroblastoma recurrent 24.96 12.03 10 126559 64 29825845
Glioma 24.93 12.03 16 126553 303 29825606
Hypertensive crisis 24.92 12.03 3 126566 8354 29817555
Glioblastoma multiforme 24.87 12.03 24 126545 839 29825070
Juvenile melanoma benign 24.83 12.03 10 126559 65 29825844
Metastases to skin 24.72 12.03 17 126552 363 29825546
Erectile dysfunction 24.68 12.03 24 126545 18078 29807831
Burning sensation 24.68 12.03 20 126549 16454 29809455
Anaemia 24.59 12.03 1094 125475 206898 29619011
Transformation to acute myeloid leukaemia 24.58 12.03 21 126548 625 29825284
Metastases to bone marrow 24.55 12.03 19 126550 490 29825419
Gait inability 24.53 12.03 26 126543 18815 29807094
Polyomavirus viraemia 24.45 12.03 19 126550 493 29825416
Respiratory depression 24.44 12.03 9 126560 11494 29814415
Blood culture positive 24.40 12.03 60 126509 4859 29821050
Rotavirus infection 24.26 12.03 16 126553 318 29825591
Wound 24.24 12.03 11 126558 12391 29813518
Burkitt's lymphoma 24.20 12.03 13 126556 174 29825735
Acute respiratory distress syndrome 24.14 12.03 176 126393 23296 29802613
Intestinal perforation 24.04 12.03 85 126484 8434 29817475
Mucoepidermoid carcinoma 24.00 12.03 7 126562 13 29825896
Central nervous system vasculitis 23.97 12.03 17 126552 382 29825527
Streptococcal infection 23.96 12.03 58 126511 4650 29821259
Haemorrhage 23.68 12.03 107 126462 45972 29779937
Muscle rigidity 23.60 12.03 7 126562 10254 29815655
Glomerulosclerosis 23.59 12.03 21 126548 661 29825248
Meningitis enteroviral 23.53 12.03 9 126560 50 29825859
Immunosuppression 23.45 12.03 61 126508 5114 29820795
Steroid diabetes 23.43 12.03 28 126541 1253 29824656
Precursor T-lymphoblastic lymphoma/leukaemia 23.40 12.03 10 126559 77 29825832
Pulmonary alveolar haemorrhage 23.37 12.03 71 126498 6510 29819399
Rash pruritic 23.36 12.03 37 126532 22535 29803374
Discomfort 23.35 12.03 16 126553 14340 29811569
Acute lung injury 23.28 12.03 26 126543 1081 29824828
Mucosal toxicity 23.26 12.03 13 126556 189 29825720
Rectal haemorrhage 23.25 12.03 73 126496 34866 29791043
Escherichia bacteraemia 23.22 12.03 43 126526 2859 29823050
Coronary artery stenosis 23.15 12.03 5 126564 9065 29816844
Spermatozoa abnormal 23.09 12.03 9 126560 53 29825856
Diaphragm muscle weakness 23.07 12.03 10 126559 80 29825829
Left ventricular dysfunction 23.07 12.03 85 126484 8606 29817303
Ocular hyperaemia 23.05 12.03 5 126564 9038 29816871
Tidal volume decreased 23.03 12.03 8 126561 32 29825877
Feeling hot 23.00 12.03 19 126550 15485 29810424
Pneumatosis intestinalis 22.97 12.03 41 126528 2649 29823260
Hepatitis viral 22.90 12.03 18 126551 475 29825434
Splenic candidiasis 22.86 12.03 10 126559 82 29825827
Splenomegaly 22.77 12.03 115 126454 13365 29812544
B precursor type acute leukaemia 22.76 12.03 10 126559 83 29825826
Enterococcal bacteraemia 22.76 12.03 29 126540 1387 29824522
Ageusia 22.72 12.03 5 126564 8948 29816961
Glycosylated haemoglobin increased 22.71 12.03 6 126563 9485 29816424
Sopor 22.68 12.03 9 126560 10982 29814927
Stenotrophomonas infection 22.61 12.03 31 126538 1593 29824316
Oroantral fistula 22.53 12.03 14 126555 250 29825659
Diabetes mellitus inadequate control 22.44 12.03 13 126556 12749 29813160
Glomerulonephritis rapidly progressive 22.41 12.03 17 126552 425 29825484
Poisoning 22.40 12.03 10 126559 11372 29814537
Adenoviral hepatitis 22.38 12.03 12 126557 160 29825749
Graft versus host disease in lung 22.30 12.03 18 126551 494 29825415
Chronic myelomonocytic leukaemia 22.30 12.03 20 126549 636 29825273
Meningeal neoplasm 22.29 12.03 9 126560 59 29825850
Pneumaturia 22.28 12.03 8 126561 36 29825873
Hypoaesthesia 22.23 12.03 136 126433 54094 29771815
Presyncope 22.23 12.03 21 126548 16035 29809874
Sarcoma metastatic 22.16 12.03 10 126559 89 29825820
Diffuse large B-cell lymphoma stage III 22.16 12.03 9 126560 60 29825849
Melaena 22.13 12.03 67 126502 32370 29793539
Psychomotor hyperactivity 22.11 12.03 4 126565 8220 29817689
Adverse drug reaction 22.05 12.03 40 126529 23105 29802804
Stevens-Johnson syndrome 22.00 12.03 25 126544 17531 29808378
Rhabdomyosarcoma recurrent 21.97 12.03 10 126559 91 29825818
Ejection fraction decreased 21.91 12.03 124 126445 15051 29810858
Basophilia 21.78 12.03 6 126563 8 29825901
Panic attack 21.72 12.03 5 126564 8676 29817233
Granulocyte count decreased 21.70 12.03 20 126549 659 29825250
Hip fracture 21.54 12.03 10 126559 11114 29814795
Metastases to spleen 21.50 12.03 15 126554 328 29825581
Abdominal lymphadenopathy 21.49 12.03 18 126551 521 29825388
Meningitis cryptococcal 21.48 12.03 34 126535 1990 29823919
Cellulitis gangrenous 21.44 12.03 12 126557 175 29825734
Carbohydrate antigen 15-3 increased 21.43 12.03 9 126560 66 29825843
Prescribed overdose 21.29 12.03 5 126564 8556 29817353
Capnocytophaga infection 21.13 12.03 8 126561 43 29825866
T-cell type acute leukaemia 21.08 12.03 12 126557 181 29825728
Iron deficiency anaemia 21.04 12.03 6 126563 9018 29816891
Enterobacter infection 20.96 12.03 34 126535 2032 29823877
Hypofibrinogenaemia 20.82 12.03 30 126539 1615 29824294
Adenocarcinoma gastric 20.79 12.03 25 126544 1126 29824783
Intestinal atresia 20.77 12.03 9 126560 72 29825837
Metapneumovirus infection 20.75 12.03 18 126551 547 29825362
Frequent bowel movements 20.72 12.03 5 126564 8400 29817509
Urinary tract infection 20.69 12.03 205 126364 73454 29752455
Hepatic candidiasis 20.69 12.03 8 126561 46 29825863
Fluid retention 20.59 12.03 47 126522 24951 29800958
Disseminated varicella zoster virus infection 20.50 12.03 23 126546 961 29824948
Polyomavirus test positive 20.48 12.03 10 126559 108 29825801
Focal nodular hyperplasia 20.42 12.03 11 126558 148 29825761
Blood cholesterol increased 20.37 12.03 25 126544 16945 29808964
Multiple-drug resistance 20.37 12.03 41 126528 2900 29823009
Mood altered 20.16 12.03 5 126564 8245 29817664
Achromobacter infection 20.13 12.03 8 126561 50 29825859
Sleep apnoea syndrome 20.06 12.03 25 126544 16832 29809077
Lower respiratory tract infection fungal 20.05 12.03 18 126551 573 29825336
Dystonia 20.01 12.03 8 126561 9719 29816190
Tooth development disorder 19.96 12.03 6 126563 13 29825896
Pulmonary veno-occlusive disease 19.95 12.03 16 126553 435 29825474
Swelling face 19.89 12.03 37 126532 21167 29804742
Mood swings 19.88 12.03 4 126565 7622 29818287
Clostridium colitis 19.84 12.03 26 126543 1279 29824630
Vascular access complication 19.83 12.03 12 126557 204 29825705
Orthostatic hypotension 19.81 12.03 45 126524 23934 29801975
Metastases to retroperitoneum 19.73 12.03 12 126557 206 29825703
Device malfunction 19.65 12.03 5 126564 8106 29817803
Antithrombin III decreased 19.64 12.03 15 126554 379 29825530
Peripheral T-cell lymphoma unspecified stage IV 19.59 12.03 7 126562 31 29825878
Lethargy 19.58 12.03 93 126476 39426 29786483
Subdural hygroma 19.54 12.03 14 126555 320 29825589
Ameloblastoma 19.48 12.03 9 126560 85 29825824
Pericarditis 19.45 12.03 80 126489 8526 29817383
Haemolysis 19.42 12.03 71 126498 7160 29818749
Toxoplasmosis 19.41 12.03 23 126546 1020 29824889
Kidney fibrosis 19.39 12.03 33 126536 2052 29823857
Blastic plasmacytoid dendritic cell neoplasia 19.39 12.03 9 126560 86 29825823
Limb discomfort 19.36 12.03 7 126562 9043 29816866
Eye pain 19.36 12.03 13 126556 11776 29814133
Chromaturia 19.35 12.03 18 126551 13847 29812062
Periorbital infection 19.35 12.03 10 126559 123 29825786
Hepatomegaly 19.34 12.03 89 126480 9958 29815951
Viral test positive 19.33 12.03 12 126557 214 29825695
Benign prostatic hyperplasia 19.30 12.03 10 126559 10437 29815472
Blood lactate dehydrogenase increased 19.23 12.03 151 126418 20450 29805459
Product use issue 19.22 12.03 287 126282 45729 29780180
Limb injury 19.16 12.03 7 126562 8984 29816925
Underdose 19.13 12.03 14 126555 12127 29813782
Intussusception 19.13 12.03 17 126552 534 29825375
Refractory cytopenia with unilineage dysplasia 18.96 12.03 16 126553 468 29825441
Cerebral salt-wasting syndrome 18.90 12.03 7 126562 35 29825874
Viral cardiomyopathy 18.90 12.03 7 126562 35 29825874
Facial paresis 18.87 12.03 39 126530 2811 29823098
Therapeutic response unexpected 18.85 12.03 7 126562 8896 29817013
Aplastic anaemia 18.85 12.03 59 126510 5497 29820412
Inhibin B 18.83 12.03 6 126563 17 29825892
Arteriosclerosis coronary artery 18.79 12.03 12 126557 11164 29814745
Joint stiffness 18.77 12.03 8 126561 9353 29816556
Inflammatory myofibroblastic tumour 18.73 12.03 10 126559 132 29825777
Coronary artery occlusion 18.73 12.03 12 126557 11145 29814764
Anaplastic large-cell lymphoma 18.70 12.03 11 126558 177 29825732
Haematemesis 18.69 12.03 53 126516 26150 29799759
Small intestinal perforation 18.67 12.03 29 126540 1670 29824239
Leukaemic infiltration 18.57 12.03 8 126561 63 29825846
Multiple sclerosis 18.56 12.03 4 126565 7263 29818646
Actinomycosis 18.51 12.03 15 126554 414 29825495
Desmoid tumour 18.45 12.03 9 126560 97 29825812
Rubulavirus test positive 18.44 12.03 5 126564 6 29825903
Eye disorder 18.30 12.03 5 126564 7729 29818180
Splenic marginal zone lymphoma 18.28 12.03 7 126562 39 29825870
Accidental exposure to product 18.22 12.03 10 126559 10105 29815804
Chronic kidney disease 18.19 12.03 90 126479 37748 29788161
Haematoma 18.17 12.03 47 126522 23906 29802003
Morphoea 18.16 12.03 10 126559 141 29825768
Positron emission tomogram abnormal 18.14 12.03 9 126560 101 29825808
Lymphocytosis 18.09 12.03 31 126538 1939 29823970
Cystitis escherichia 18.02 12.03 11 126558 190 29825719
Non-Hodgkin's lymphoma 18.01 12.03 29 126540 1722 29824187
Hepatic amoebiasis 17.94 12.03 8 126561 69 29825840
Medulloblastoma recurrent 17.94 12.03 8 126561 69 29825840
Infusion site discolouration 17.91 12.03 9 126560 104 29825805
Adenoviral upper respiratory infection 17.88 12.03 4 126565 0 29825909
Personality change due to a general medical condition 17.85 12.03 7 126562 42 29825867
Hypertension 17.80 12.03 384 126185 120970 29704939
Hepatitis B DNULL increased 17.78 12.03 16 126553 511 29825398
Hepatitis D 17.72 12.03 7 126562 43 29825866
Human herpesvirus 6 encephalitis 17.62 12.03 10 126559 150 29825759
Tooth deposit 17.61 12.03 9 126560 108 29825801
Dementia 17.60 12.03 16 126553 12445 29813464
Pemphigoid 17.56 12.03 5 126564 7523 29818386
Tendonitis 17.56 12.03 6 126563 8030 29817879
Epstein-Barr virus test positive 17.47 12.03 16 126553 523 29825386
Viral vasculitis 17.46 12.03 8 126561 74 29825835
Sphingomonas paucimobilis infection 17.45 12.03 7 126562 45 29825864
Central nervous system enteroviral infection 17.45 12.03 7 126562 45 29825864
Bone marrow transplant 17.45 12.03 21 126548 947 29824962
Metastases to muscle 17.44 12.03 11 126558 202 29825707
Product storage error 17.42 12.03 3 126566 6388 29819521
Testicular disorder 17.41 12.03 17 126552 603 29825306
Evans syndrome 17.38 12.03 12 126557 258 29825651
Organising pneumonia 17.32 12.03 54 126515 5020 29820889
Blood creatinine increased 17.17 12.03 277 126292 91098 29734811
Disturbance in attention 17.12 12.03 43 126526 22086 29803823
Ischaemic cardiomyopathy 17.06 12.03 3 126566 6294 29819615
Pneumonia parainfluenzae viral 17.05 12.03 9 126560 116 29825793
Fungal sepsis 17.02 12.03 18 126551 703 29825206
Encephalitis cytomegalovirus 17.02 12.03 14 126555 395 29825514
Eating disorder 16.95 12.03 4 126565 6823 29819086
Acanthamoeba infection 16.85 12.03 15 126554 472 29825437
Suspected product quality issue 16.84 12.03 10 126559 164 29825745
Human rhinovirus test positive 16.84 12.03 10 126559 164 29825745
Hyperpyrexia 16.76 12.03 35 126534 2542 29823367
Disorientation 16.72 12.03 72 126497 31346 29794563
Inflammatory pseudotumour 16.71 12.03 6 126563 27 29825882
Cryptococcal fungaemia 16.67 12.03 8 126561 83 29825826
Abdominal wall abscess 16.64 12.03 15 126554 480 29825429
Conus medullaris syndrome 16.59 12.03 5 126564 11 29825898
POEMS syndrome 16.54 12.03 6 126563 28 29825881
Ileus paralytic 16.49 12.03 57 126512 5591 29820318
Arteriosclerosis 16.42 12.03 13 126556 10820 29815089
Pneumonia aspiration 16.41 12.03 93 126476 37687 29788222
Device occlusion 16.40 12.03 3 126566 6117 29819792
Humoral immune defect 16.37 12.03 7 126562 54 29825855
Marginal zone lymphoma recurrent 16.37 12.03 6 126563 29 29825880
Granulocytopenia neonatal 16.37 12.03 6 126563 29 29825880
Tricuspid valve incompetence 16.31 12.03 8 126561 8615 29817294
Transaminases increased 16.23 12.03 161 126408 23296 29802613
Autoimmune pancytopenia 16.18 12.03 8 126561 89 29825820
Infection in an immunocompromised host 16.18 12.03 17 126552 659 29825250
Adenocarcinoma of colon 16.16 12.03 40 126529 3252 29822657
Renal amyloidosis 16.15 12.03 7 126562 56 29825853
Splenic lesion 16.15 12.03 9 126560 130 29825779
Blood loss anaemia 16.15 12.03 6 126563 7621 29818288
Gastric stenosis 15.89 12.03 6 126563 32 29825877
Epstein-Barr virus infection reactivation 15.83 12.03 11 126558 239 29825670
Alpha haemolytic streptococcal infection 15.76 12.03 18 126551 767 29825142
Atypical teratoid/rhabdoid tumour of CNS 15.74 12.03 5 126564 14 29825895
Renal salt-wasting syndrome 15.68 12.03 9 126560 138 29825771
Viraemia 15.66 12.03 22 126547 1157 29824752
Morganella infection 15.65 12.03 13 126556 372 29825537
Primary amyloidosis 15.64 12.03 7 126562 61 29825848
Akathisia 15.60 12.03 3 126566 5901 29820008
Cutaneous T-cell lymphoma recurrent 15.59 12.03 6 126563 34 29825875
Neurological decompensation 15.59 12.03 32 126537 2296 29823613
Arthritis 15.52 12.03 52 126517 24349 29801560
Thirst 15.52 12.03 5 126564 6944 29818965
Gallbladder adenocarcinoma 15.49 12.03 5 126564 15 29825894
Coxsackie viral infection 15.49 12.03 5 126564 15 29825894
Candida endophthalmitis 15.44 12.03 8 126561 99 29825810
Gynaecomastia 15.42 12.03 8 126561 8343 29817566
Pleural mass 15.35 12.03 7 126562 64 29825845
Fusobacterium infection 15.35 12.03 7 126562 64 29825845
Platelet transfusion 15.35 12.03 20 126549 978 29824931
Tongue fungal infection 15.30 12.03 6 126563 36 29825873
Abdominal neoplasm 15.28 12.03 10 126559 196 29825713
Medulloblastoma 15.26 12.03 7 126562 65 29825844
Drug level decreased 15.23 12.03 3 126566 5802 29820107
Acinetobacter infection 15.16 12.03 20 126549 990 29824919
Serum ferritin increased 15.13 12.03 54 126515 5383 29820526
Phlebitis infective 15.08 12.03 9 126560 149 29825760
Lip swelling 15.06 12.03 19 126550 12725 29813184
Hepatosplenic T-cell lymphoma 15.05 12.03 14 126555 467 29825442
Rib fracture 15.00 12.03 19 126550 12701 29813208
VIth nerve paralysis 14.97 12.03 17 126552 720 29825189
Blood pressure decreased 14.96 12.03 127 126442 46948 29778961
Lupus nephritis 14.89 12.03 11 126558 264 29825645
Movement disorder 14.80 12.03 12 126557 9871 29816038
Ventricular extrasystoles 14.75 12.03 16 126553 11458 29814451
Dysphonia 14.70 12.03 37 126532 18995 29806914
Respiratory distress 14.69 12.03 208 126361 32764 29793145
Pneumococcal infection 14.57 12.03 12 126557 339 29825570
Cord blood transplant therapy 14.53 12.03 6 126563 42 29825867
Refractoriness to platelet transfusion 14.53 12.03 6 126563 42 29825867
Gastritis erosive 14.52 12.03 3 126566 5610 29820299
Escherichia test positive 14.45 12.03 20 126549 1037 29824872
Vascular injury 14.43 12.03 11 126558 277 29825632
Leukaemia cutis 14.41 12.03 6 126563 43 29825866
CSF protein increased 14.40 12.03 17 126552 751 29825158
Pulmonary haemorrhage 14.40 12.03 78 126491 9314 29816595
Helicobacter sepsis 14.39 12.03 5 126564 20 29825889
Lung adenocarcinoma 14.34 12.03 44 126525 4055 29821854
Peripheral T-cell lymphoma unspecified stage III 14.29 12.03 6 126563 44 29825865
Enteropathy-associated T-cell lymphoma 14.24 12.03 4 126565 6 29825903
Kidney transplant rejection 14.15 12.03 7 126562 7502 29818407
Superior vena cava syndrome 14.12 12.03 13 126556 428 29825481
Hepatitis B surface antigen positive 14.09 12.03 8 126561 120 29825789
Gingival hypertrophy 14.08 12.03 25 126544 1608 29824301
Bronchitis 14.08 12.03 102 126467 39023 29786886
Diffuse large B-cell lymphoma stage II 14.06 12.03 6 126563 46 29825863
Cerebrosclerosis 14.02 12.03 5 126564 22 29825887
Glottis carcinoma 14.02 12.03 5 126564 22 29825887
Opportunistic infection 13.97 12.03 22 126547 1282 29824627
Blood HIV RNULL increased 13.95 12.03 23 126546 1393 29824516
Thrombosis 13.84 12.03 113 126456 42118 29783791
Skin mass 13.73 12.03 39 126530 3443 29822466
Hepatic enzyme increased 13.72 12.03 84 126485 33410 29792499
Toxic neuropathy 13.72 12.03 12 126557 369 29825540
Viral diarrhoea 13.70 12.03 8 126561 127 29825782
Delayed engraftment 13.70 12.03 7 126562 84 29825825
Premature ageing 13.70 12.03 7 126562 84 29825825
Device related thrombosis 13.69 12.03 17 126552 792 29825117
Cytomegalovirus hepatitis 13.69 12.03 11 126558 300 29825609
Pneumonia measles 13.67 12.03 5 126564 24 29825885
Blood urine present 13.64 12.03 13 126556 9887 29816022
Intestinal obstruction 13.60 12.03 39 126530 19173 29806736
Hyperbilirubinaemia 13.58 12.03 120 126449 16822 29809087
Respiratory syncytial virus infection 13.55 12.03 38 126531 3330 29822579
Viral skin infection 13.52 12.03 4 126565 8 29825901
Ganglioneuroma 13.52 12.03 4 126565 8 29825901
Lymphoplasmacytoid lymphoma/immunocytoma recurrent 13.52 12.03 4 126565 8 29825901
Prescribed underdose 13.51 12.03 8 126561 7751 29818158
Femur fracture 13.50 12.03 7 126562 7302 29818607
Clostridium test positive 13.46 12.03 28 126541 2028 29823881
Neoplasm 13.44 12.03 43 126526 4053 29821856
Haemorrhoids 13.44 12.03 19 126550 12122 29813787
Hepatitis B e antigen positive 13.43 12.03 6 126563 52 29825857
Dyspnoea exertional 13.42 12.03 91 126478 35339 29790570
Therapeutic product ineffective for unapproved indication 13.41 12.03 3 126566 0 29825909
Retrograde portal vein flow 13.41 12.03 3 126566 0 29825909
Hepatosplenic abscess 13.41 12.03 3 126566 0 29825909
Disseminated large cell lymphoma 13.41 12.03 3 126566 0 29825909
Autologous haematopoietic stem cell transplant 13.41 12.03 3 126566 0 29825909
Klippel-Feil syndrome 13.41 12.03 3 126566 0 29825909
Chylothorax 13.40 12.03 15 126554 625 29825284
Blood immunoglobulin A decreased 13.39 12.03 10 126559 244 29825665
Muscle twitching 13.38 12.03 9 126560 8146 29817763
Viral myocarditis 13.37 12.03 8 126561 133 29825776
Embryonal rhabdomyosarcoma 13.34 12.03 5 126564 26 29825883
Tooth malformation 13.34 12.03 5 126564 26 29825883
Hypokinesia 13.34 12.03 7 126562 7253 29818656
Viral load increased 13.30 12.03 34 126535 2820 29823089
Ureaplasma infection 13.26 12.03 9 126560 188 29825721
Gastric disorder 13.23 12.03 15 126554 10528 29815381
Stomatitis necrotising 13.21 12.03 7 126562 91 29825818
Angina pectoris 13.18 12.03 72 126497 29446 29796463
Geotrichum infection 13.18 12.03 13 126556 467 29825442
Cytomegalovirus enterocolitis 13.18 12.03 17 126552 823 29825086
Peliosis hepatis 13.14 12.03 6 126563 55 29825854
Electrocardiogram T wave biphasic 13.14 12.03 6 126563 55 29825854
Diverticulum 13.12 12.03 6 126563 6727 29819182
Epistaxis 13.04 12.03 152 126417 52829 29773080
Follicular mucinosis 13.04 12.03 5 126564 28 29825881
Skin exfoliation 13.02 12.03 52 126517 23120 29802789
Cough 13.01 12.03 418 126151 125224 29700685
Neurological symptom 13.01 12.03 38 126531 3409 29822500
Stomatococcal infection 12.97 12.03 8 126561 141 29825768
Blood potassium increased 12.93 12.03 31 126538 16182 29809727
Pulmonary oedema 12.93 12.03 121 126448 43854 29782055
Hemianopia 12.92 12.03 15 126554 651 29825258
Congenital hepatobiliary anomaly 12.89 12.03 5 126564 29 29825880
Salivary hypersecretion 12.89 12.03 8 126561 7558 29818351
Blood alkaline phosphatase increased 12.88 12.03 79 126490 31408 29794501
Drug clearance decreased 12.86 12.03 21 126548 1262 29824647
Enterocolitis infectious 12.85 12.03 20 126549 1154 29824755
Drug eruption 12.83 12.03 35 126534 17491 29808418
Mass 12.83 12.03 62 126507 7078 29818831
Gastrointestinal inflammation 12.81 12.03 34 126535 2885 29823024
Haemolytic uraemic syndrome 12.80 12.03 27 126542 1975 29823934
Hiatus hernia 12.78 12.03 7 126562 7083 29818826
Tracheal inflammation 12.78 12.03 6 126563 59 29825850
T-lymphocyte count decreased 12.78 12.03 9 126560 200 29825709
Pulmonary sarcoidosis 12.73 12.03 14 126555 572 29825337
JC polyomavirus test positive 12.73 12.03 14 126555 572 29825337
Vomiting 12.71 12.03 780 125789 219038 29606871
Biopsy lymph gland 12.69 12.03 6 126563 60 29825849
Optic nerve disorder 12.69 12.03 14 126555 574 29825335
Secondary immunodeficiency 12.66 12.03 11 126558 335 29825574
Chronic lymphocytic leukaemia stage 2 12.64 12.03 4 126565 11 29825898
Emotional disorder 12.62 12.03 3 126566 5091 29820818
Paternal exposure timing unspecified 12.62 12.03 5 126564 31 29825878
Increased appetite 12.61 12.03 4 126565 5613 29820296
Mantle cell lymphoma stage IV 12.61 12.03 6 126563 61 29825848
Extramedullary haemopoiesis 12.61 12.03 6 126563 61 29825848
Bladder spasm 12.59 12.03 17 126552 861 29825048
Crying 12.59 12.03 4 126565 5605 29820304
Fungal test positive 12.54 12.03 13 126556 496 29825413
Blister 12.53 12.03 45 126524 20638 29805271
White blood cell count abnormal 12.52 12.03 32 126537 2654 29823255
Palatal ulcer 12.48 12.03 5 126564 32 29825877
Rhabdomyosarcoma 12.44 12.03 6 126563 63 29825846
Autonomic neuropathy 12.44 12.03 17 126552 871 29825038
Streptococcal bacteraemia 12.44 12.03 24 126545 1646 29824263
Peripheral T-cell lymphoma unspecified refractory 12.39 12.03 4 126565 12 29825897
Metastases to lymph nodes 12.37 12.03 41 126528 3936 29821973
Gout 12.36 12.03 35 126534 17280 29808629
Ureteric compression 12.35 12.03 5 126564 33 29825876
Schizophrenia 12.33 12.03 12 126557 9036 29816873
Exophthalmos 12.33 12.03 13 126556 506 29825403
Abdominal pain 12.28 12.03 459 126110 135195 29690714
Pulmonary mucormycosis 12.26 12.03 12 126557 427 29825482
Fracture 12.26 12.03 5 126564 6001 29819908
Urinary retention 12.24 12.03 85 126484 32832 29793077
Epstein-Barr virus antigen positive 12.23 12.03 5 126564 34 29825875
Miosis 12.21 12.03 9 126560 7767 29818142
Central nervous system haemorrhage 12.19 12.03 6 126563 66 29825843
Bacteroides bacteraemia 12.15 12.03 4 126565 13 29825896
Visual impairment 12.13 12.03 77 126492 30361 29795548
Extravasation 12.09 12.03 25 126544 1803 29824106
Post lumbar puncture syndrome 12.09 12.03 8 126561 160 29825749
Restless legs syndrome 12.08 12.03 7 126562 6865 29819044
Choking 12.08 12.03 3 126566 4943 29820966
Soft tissue mass 12.07 12.03 10 126559 285 29825624
Pneumonia respiratory syncytial viral 12.07 12.03 14 126555 607 29825302
Throat irritation 12.05 12.03 11 126558 8537 29817372

Pharmacologic Action:

SourceCodeDescription
ATC L01AA01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ALKYLATING AGENTS
Nitrogen mustard analogues
CHEBI has role CHEBI:35610 cytostatic
CHEBI has role CHEBI:35705 immunosuppressant
CHEBI has role CHEBI:50903 cancerogene
MeSH PA D000477 Alkylating Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018906 Antineoplastic Agents, Alkylating
MeSH PA D018501 Antirheumatic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009153 Mutagens
MeSH PA D019653 Myeloablative Agonists
MeSH PA D009676 Noxae

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Multiple myeloma indication 109989006 DOID:9538
Malignant lymphoma indication 118600007 DOID:0060058
Mycosis fungoides indication 118618005
Carcinoma of breast indication 254838004 DOID:3459
Retinoblastoma indication 370967009 DOID:768
Neuroblastoma indication 432328008 DOID:769

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.39 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cytochrome P450 3A4 Enzyme IC50 5.68 WOMBAT-PK
DNA DNA OTHER CHEMBL CHEMBL

External reference:

IDSource
4018114 VUID
N0000146452 NUI
D00287 KEGG_DRUG
6055-19-2 SECONDARY_CAS_RN
4018114 VANDF
C0010583 UMLSCUI
CHEBI:4026 CHEBI
CHEMBL88 ChEMBL_ID
CHEMBL1200796 ChEMBL_ID
DB00531 DRUGBANK_ID
D003520 MESH_DESCRIPTOR_UI
2907 PUBCHEM_CID
7154 IUPHAR_LIGAND_ID
8N3DW7272P UNII
3002 RXNORM
31952 MMSL
4519 MMSL
d00036 MMSL
002631 NDDF
387420009 SNOMEDCT_US
74470007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0054-0382 CAPSULE 25 mg ORAL NDA 27 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0054-0383 CAPSULE 50 mg ORAL NDA 27 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3233 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3244 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3255 INJECTION, POWDER, FOR SOLUTION 2 g ORAL ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-935 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-936 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-937 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-938 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-939 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-942 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-943 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-944 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 10019-945 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-955 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-956 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-957 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-982 TABLET 25 mg ORAL NDA authorized generic 27 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 10019-984 TABLET 50 mg ORAL NDA 27 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 16714-857 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 16714-858 INJECTION, POWDER, FOR SOLUTION 2 g ORAL ANDA 25 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 16714-859 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 43975-307 CAPSULE 25 mg ORAL ANDA 27 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 43975-308 CAPSULE 50 mg ORAL ANDA 27 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 54868-5005 TABLET 50 mg ORAL ANDA 19 sections
Cyclophosphamide HUMAN PRESCRIPTION DRUG LABEL 1 54868-5218 TABLET 25 mg ORAL ANDA 19 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 54879-021 CAPSULE 25 mg ORAL ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 54879-022 CAPSULE 50 mg ORAL ANDA 25 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 62559-930 CAPSULE 25 mg ORAL ANDA 27 sections
CYCLOPHOSPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 1 62559-931 CAPSULE 50 mg ORAL ANDA 27 sections