cyclopentolate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
757 512-15-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cyclopentolate
  • cyclopentolate hydrochloride
  • cyclogyl
  • cyclopentylate
  • cyclopentolate HCl
A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia.
  • Molecular weight: 291.39
  • Formula: C17H25NO3
  • CLOGP: 2.69
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 49.77
  • ALOGS: -2.29
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 31, 1974 FDA ALCON LABS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic anterior segment syndrome 164.36 123.98 20 106 273 2357686
Corneal oedema 124.70 123.98 16 110 336 2357623

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intraocular pressure increased 78.31 72.28 13 95 1168 1745505

Pharmacologic Action:

SourceCodeDescription
ATC S01FA04 SENSORY ORGANS
OPHTHALMOLOGICALS
MYDRIATICS AND CYCLOPLEGICS
Anticholinergics
ATC S01FA54 SENSORY ORGANS
OPHTHALMOLOGICALS
MYDRIATICS AND CYCLOPLEGICS
Anticholinergics
CHEBI has role CHEBI:50513 mydriatic agent
CHEBI has role CHEBI:50370 parasympatholytic
CHEBI has role CHEBI:48876 muscarinic antagonist
CHEBI has role CHEBI:33295 diagnostic agent
MeSH PA D018678 Cholinergic Agents
MeSH PA D018680 Cholinergic Antagonists
MeSH PA D018727 Muscarinic Antagonists
MeSH PA D009184 Mydriatics
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D010276 Parasympatholytics
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Dilated pupil indication 37125009
Cycloplegia indication 68158006 DOID:10033
Perioperative Mydriasis indication
Uveitis off-label use 128473001 DOID:13141
Prevention of Posterior Synechiae off-label use
Brain damage contraindication 2470005
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Conduction disorder of the heart contraindication 44808001
Heart disease contraindication 56265001 DOID:114
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Spastic paralysis contraindication 78403003
Arterial aneurysm contraindication 233981004
Benign prostatic hyperplasia contraindication 266569009
Angle-closure glaucoma contraindication 392291006 DOID:13550
Disorder of coronary artery contraindication 414024009
Predisposition to Glaucoma contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M3 GPCR ANTAGONIST CHEMBL CHEMBL

External reference:

IDSource
D003519 MESH_DESCRIPTOR_UI
4019700 VUID
N0000147792 NUI
C0010582 UMLSCUI
D01002 KEGG_DRUG
736I6971TE UNII
5870-29-1 SECONDARY_CAS_RN
8348002 SNOMEDCT_US
4019700 VANDF
004703 NDDF
3001 RXNORM
372869004 SNOMEDCT_US
CHEBI:4024 CHEBI
DB00979 DRUGBANK_ID
CHEMBL1200473 ChEMBL_ID
266 INN_ID
7153 IUPHAR_LIGAND_ID
2905 PUBCHEM_CID
CHEMBL1201338 ChEMBL_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cyclomydril HUMAN PRESCRIPTION DRUG LABEL 2 0065-0359 SOLUTION/ DROPS 2 mg OPHTHALMIC ANDA 12 sections
Cyclogyl HUMAN PRESCRIPTION DRUG LABEL 1 0065-0395 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 12 sections
Cyclogyl HUMAN PRESCRIPTION DRUG LABEL 1 0065-0396 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 12 sections
Cyclogyl HUMAN PRESCRIPTION DRUG LABEL 1 0065-0397 SOLUTION/ DROPS 20 mg OPHTHALMIC ANDA 12 sections
Cyclopentolate HUMAN PRESCRIPTION DRUG LABEL 1 17478-096 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 12 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 17478-097 SOLUTION/ DROPS 20 mg OPHTHALMIC ANDA 12 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 17478-100 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 12 sections
AK-PENTOLATE HUMAN PRESCRIPTION DRUG LABEL 1 21695-883 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 12 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 24208-735 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 11 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 42254-013 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 13 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-3234 SOLUTION 10 mg OPHTHALMIC ANDA 12 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-3874 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 13 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 54868-4697 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 13 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 61314-396 SOLUTION 10 mg OPHTHALMIC ANDA 12 sections