cyclopentolate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 757 | 512-15-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 31, 1974 | FDA | ALCON LABS INC |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Toxic anterior segment syndrome | 164.36 | 123.98 | 20 | 106 | 273 | 2357686 |
| Corneal oedema | 124.70 | 123.98 | 16 | 110 | 336 | 2357623 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Intraocular pressure increased | 78.31 | 72.28 | 13 | 95 | 1168 | 1745505 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | S01FA04 | SENSORY ORGANS OPHTHALMOLOGICALS MYDRIATICS AND CYCLOPLEGICS Anticholinergics |
| ATC | S01FA54 | SENSORY ORGANS OPHTHALMOLOGICALS MYDRIATICS AND CYCLOPLEGICS Anticholinergics |
| CHEBI has role | CHEBI:50513 | mydriatic agent |
| CHEBI has role | CHEBI:50370 | parasympatholytic |
| CHEBI has role | CHEBI:48876 | muscarinic antagonist |
| CHEBI has role | CHEBI:33295 | diagnostic agent |
| MeSH PA | D018678 | Cholinergic Agents |
| MeSH PA | D018680 | Cholinergic Antagonists |
| MeSH PA | D018727 | Muscarinic Antagonists |
| MeSH PA | D009184 | Mydriatics |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D010276 | Parasympatholytics |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Dilated pupil | indication | 37125009 | |
| Cycloplegia | indication | 68158006 | DOID:10033 |
| Perioperative Mydriasis | indication | ||
| Uveitis | off-label use | 128473001 | DOID:13141 |
| Prevention of Posterior Synechiae | off-label use | ||
| Brain damage | contraindication | 2470005 | |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Complete trisomy 21 syndrome | contraindication | 41040004 | DOID:14250 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Heart disease | contraindication | 56265001 | DOID:114 |
| Arteriosclerotic vascular disease | contraindication | 72092001 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Spastic paralysis | contraindication | 78403003 | |
| Arterial aneurysm | contraindication | 233981004 | |
| Benign prostatic hyperplasia | contraindication | 266569009 | |
| Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
| Disorder of coronary artery | contraindication | 414024009 | |
| Predisposition to Glaucoma | contraindication |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.23 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M3 | GPCR | ANTAGONIST | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D003519 | MESH_DESCRIPTOR_UI |
| 4019700 | VUID |
| N0000147792 | NUI |
| C0010582 | UMLSCUI |
| D01002 | KEGG_DRUG |
| 736I6971TE | UNII |
| 5870-29-1 | SECONDARY_CAS_RN |
| 8348002 | SNOMEDCT_US |
| 4019700 | VANDF |
| 004703 | NDDF |
| 3001 | RXNORM |
| 372869004 | SNOMEDCT_US |
| CHEBI:4024 | CHEBI |
| DB00979 | DRUGBANK_ID |
| CHEMBL1200473 | ChEMBL_ID |
| 266 | INN_ID |
| 7153 | IUPHAR_LIGAND_ID |
| 2905 | PUBCHEM_CID |
| CHEMBL1201338 | ChEMBL_ID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Cyclomydril | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0065-0359 | SOLUTION/ DROPS | 2 mg | OPHTHALMIC | ANDA | 12 sections |
| Cyclogyl | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0065-0395 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 12 sections |
| Cyclogyl | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0065-0396 | SOLUTION/ DROPS | 10 mg | OPHTHALMIC | ANDA | 12 sections |
| Cyclogyl | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0065-0397 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 12 sections |
| Cyclopentolate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-096 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 12 sections |
| Cyclopentolate Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-097 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 12 sections |
| Cyclopentolate Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-100 | SOLUTION/ DROPS | 10 mg | OPHTHALMIC | ANDA | 12 sections |
| AK-PENTOLATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-883 | SOLUTION/ DROPS | 10 mg | OPHTHALMIC | ANDA | 12 sections |
| Cyclopentolate Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24208-735 | SOLUTION/ DROPS | 10 mg | OPHTHALMIC | ANDA | 11 sections |
| Cyclopentolate Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-013 | SOLUTION/ DROPS | 10 mg | OPHTHALMIC | ANDA | 13 sections |
| Cyclopentolate Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3234 | SOLUTION | 10 mg | OPHTHALMIC | ANDA | 12 sections |
| Cyclopentolate Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3874 | SOLUTION/ DROPS | 10 mg | OPHTHALMIC | ANDA | 13 sections |
| Cyclopentolate Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4697 | SOLUTION/ DROPS | 10 mg | OPHTHALMIC | ANDA | 13 sections |
| Cyclopentolate Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61314-396 | SOLUTION | 10 mg | OPHTHALMIC | ANDA | 12 sections |