cyclopentolate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
757 512-15-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cyclopentolate
  • cyclopentolate hydrochloride
  • cyclogyl
  • cyclopentylate
  • cyclopentolate HCl
A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia.
  • Molecular weight: 291.39
  • Formula: C17H25NO3
  • CLOGP: 2.69
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 49.77
  • ALOGS: -2.29
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 31, 1974 FDA ALCON LABS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Corneal oedema 126.53 47.48 22 1084 1471 63486445
Toxic anterior segment syndrome 96.82 47.48 18 1088 1753 63486163
Keratopathy 93.75 47.48 15 1091 601 63487315
Corneal epithelium defect 86.65 47.48 13 1093 339 63487577
Anterior chamber cell 81.00 47.48 13 1093 531 63487385
Punctate keratitis 72.21 47.48 12 1094 609 63487307
Visual acuity reduced 55.86 47.48 19 1087 21807 63466109
Hypopyon 50.08 47.48 9 1097 723 63487193
Floppy iris syndrome 49.72 47.48 7 1099 115 63487801
Mydriasis 49.46 47.48 15 1091 11941 63475975

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Mydriasis 56.27 47.16 15 624 7222 34949070
Toxic anterior segment syndrome 51.58 47.16 10 629 1159 34955133

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Corneal oedema 139.71 38.17 27 1701 2593 79740067
Toxic anterior segment syndrome 138.27 38.17 27 1701 2737 79739923
Keratopathy 133.35 38.17 23 1705 1171 79741489
Corneal epithelium defect 123.28 38.17 20 1708 699 79741961
Anterior chamber cell 97.30 38.17 17 1711 932 79741728
Punctate keratitis 89.99 38.17 16 1712 970 79741690
Mydriasis 88.54 38.17 27 1701 17616 79725044
Visual acuity reduced 78.72 38.17 28 1700 29441 79713219
Eye pain 72.08 38.17 28 1700 37550 79705110
Corneal opacity 69.97 38.17 13 1715 1007 79741653
Endophthalmitis 55.39 38.17 15 1713 6413 79736247
Intraocular pressure increased 54.43 38.17 16 1712 9189 79733471
Ocular hyperaemia 50.48 38.17 20 1708 28186 79714474
Hypopyon 50.07 38.17 10 1718 1132 79741528
Vision blurred 49.64 38.17 30 1698 105868 79636792
Iridocyclitis 43.24 38.17 11 1717 3693 79738967
Eye irritation 41.72 38.17 16 1712 20665 79721995
Foreign body sensation in eyes 38.41 38.17 9 1719 2148 79740512

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01FA04 SENSORY ORGANS
OPHTHALMOLOGICALS
MYDRIATICS AND CYCLOPLEGICS
Anticholinergics
ATC S01FA54 SENSORY ORGANS
OPHTHALMOLOGICALS
MYDRIATICS AND CYCLOPLEGICS
Anticholinergics
CHEBI has role CHEBI:33295 diagnostic aid
CHEBI has role CHEBI:48876 muscarinic antagonists
CHEBI has role CHEBI:50370 parasympatholytics
CHEBI has role CHEBI:50513 mydriatics
MeSH PA D018678 Cholinergic Agents
MeSH PA D018680 Cholinergic Antagonists
MeSH PA D018727 Muscarinic Antagonists
MeSH PA D009184 Mydriatics
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D010276 Parasympatholytics
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Dilated pupil indication 37125009
Cycloplegia indication 68158006 DOID:10033
Perioperative Mydriasis indication
Uveitis off-label use 128473001 DOID:13141
Prevention of Posterior Synechiae off-label use
Brain damage contraindication 2470005
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Conduction disorder of the heart contraindication 44808001
Heart disease contraindication 56265001 DOID:114
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Spastic paralysis contraindication 78403003
Arterial aneurysm contraindication 233981004
Benign prostatic hyperplasia contraindication 266569009
Angle-closure glaucoma contraindication 392291006 DOID:13550
Disorder of coronary artery contraindication 414024009
Predisposition to Glaucoma contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M3 GPCR ANTAGONIST CHEMBL CHEMBL

External reference:

IDSource
4019700 VUID
N0000147792 NUI
D01002 KEGG_DRUG
5870-29-1 SECONDARY_CAS_RN
106029 RXNORM
4018593 VANDF
4019700 VANDF
C0010582 UMLSCUI
CHEBI:4024 CHEBI
CHEMBL1201338 ChEMBL_ID
DB00979 DRUGBANK_ID
CHEMBL1200473 ChEMBL_ID
D003519 MESH_DESCRIPTOR_UI
2905 PUBCHEM_CID
7153 IUPHAR_LIGAND_ID
266 INN_ID
I76F4SHP7J UNII
225 MMSL
242 MMSL
39891 MMSL
4518 MMSL
001752 NDDF
004703 NDDF
372869004 SNOMEDCT_US
8348002 SNOMEDCT_US
83534009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cyclomydril HUMAN PRESCRIPTION DRUG LABEL 2 0065-0359 SOLUTION/ DROPS 2 mg OPHTHALMIC ANDA 20 sections
Cyclomydril HUMAN PRESCRIPTION DRUG LABEL 2 0065-0359 SOLUTION/ DROPS 2 mg OPHTHALMIC ANDA 20 sections
Cyclogyl HUMAN PRESCRIPTION DRUG LABEL 1 0065-0395 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 20 sections
Cyclogyl HUMAN PRESCRIPTION DRUG LABEL 1 0065-0395 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 20 sections
Cyclogyl HUMAN PRESCRIPTION DRUG LABEL 1 0065-0396 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 20 sections
Cyclogyl HUMAN PRESCRIPTION DRUG LABEL 1 0065-0396 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 20 sections
Cyclogyl HUMAN PRESCRIPTION DRUG LABEL 1 0065-0397 SOLUTION/ DROPS 20 mg OPHTHALMIC ANDA 20 sections
Cyclogyl HUMAN PRESCRIPTION DRUG LABEL 1 0065-0397 SOLUTION/ DROPS 20 mg OPHTHALMIC ANDA 20 sections
Cyclopentolate HUMAN PRESCRIPTION DRUG LABEL 1 17478-096 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 12 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 17478-097 SOLUTION/ DROPS 20 mg OPHTHALMIC ANDA 20 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 17478-097 SOLUTION/ DROPS 20 mg OPHTHALMIC ANDA 20 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 17478-097 SOLUTION/ DROPS 20 mg OPHTHALMIC ANDA 20 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 17478-100 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 20 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 17478-100 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 20 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 17478-100 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 20 sections
AK-PENTOLATE HUMAN PRESCRIPTION DRUG LABEL 1 21695-883 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 19 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 24208-735 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 20 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 24208-735 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 20 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 42254-013 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 21 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-3234 SOLUTION 10 mg OPHTHALMIC ANDA 20 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-3874 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 20 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 54868-4697 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 21 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 61314-396 SOLUTION 10 mg OPHTHALMIC ANDA 20 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 61314-396 SOLUTION 10 mg OPHTHALMIC ANDA 20 sections