cyclopentolate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
757 512-15-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cyclopentolate
  • cyclopentolate hydrochloride
  • cyclogyl
  • cyclopentylate
  • cyclopentolate HCl
A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia.
  • Molecular weight: 291.39
  • Formula: C17H25NO3
  • CLOGP: 2.69
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 49.77
  • ALOGS: -2.29
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,MAP3K7,MAPK12,MAPK7,MET,NTRK2,PDK2,PDK4,PIK3CB,PRKDC,SIK2,SIK3,TEK,TGFBR1 29
kinase-selectivity-class AXL,PDK4 2
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
July 31, 1974 FDA ALCON LABS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Corneal oedema 126.00 46.20 22 1247 1879 90625299
Toxic anterior segment syndrome 109.26 46.20 20 1249 2230 90624948
Keratopathy 94.93 46.20 15 1254 693 90626485
Corneal epithelium defect 85.16 46.20 13 1256 478 90626700
Anterior chamber cell 79.90 46.20 13 1256 723 90626455
Punctate keratitis 71.85 46.20 12 1257 784 90626394
Eye pain 57.37 46.20 22 1247 44146 90583032
Endophthalmitis 55.89 46.20 13 1256 4672 90622506
Visual acuity reduced 54.56 46.20 18 1251 23392 90603786
Iridocyclitis 53.58 46.20 12 1257 3649 90623529
Floppy iris syndrome 51.25 46.20 7 1262 115 90627063
Retinal detachment 51.04 46.20 13 1256 6809 90620369
Hypopyon 50.05 46.20 9 1260 905 90626273
Mydriasis 49.31 46.20 15 1254 14997 90612181
Presyncope 49.16 46.20 18 1251 31787 90595391

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Mydriasis 59.35 40.22 16 699 8754 42611866
Scleromalacia 56.53 40.22 7 708 41 42620579
Toxic anterior segment syndrome 50.52 40.22 10 705 1406 42619214
Corneal opacity 44.66 40.22 8 707 657 42619963
Keratopathy 44.27 40.22 8 707 690 42619930
Corneal epithelium defect 41.32 40.22 7 708 415 42620205

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic anterior segment syndrome 149.79 36.89 29 1941 3425 110583904
Keratopathy 134.62 36.89 23 1947 1350 110585979
Corneal oedema 133.64 36.89 26 1944 3147 110584182
Corneal epithelium defect 122.43 36.89 20 1950 892 110586437
Anterior chamber cell 96.34 36.89 17 1953 1204 110586125
Punctate keratitis 89.92 36.89 16 1954 1188 110586141
Mydriasis 87.66 36.89 27 1943 22130 110565199
Eye pain 83.68 36.89 32 1938 50067 110537262
Visual acuity reduced 73.92 36.89 26 1944 32147 110555182
Endophthalmitis 73.76 36.89 19 1951 8168 110579161
Corneal opacity 69.86 36.89 13 1957 1238 110586091
Ocular hyperaemia 58.15 36.89 23 1947 39263 110548066
Iridocyclitis 55.85 36.89 14 1956 5394 110581935
Vision blurred 54.80 36.89 32 1938 128990 110458339
Uveitis 51.59 36.89 18 1952 21692 110565637
Intraocular pressure increased 50.49 36.89 15 1955 10861 110576468
Hypopyon 49.71 36.89 10 1960 1430 110585899
Scleromalacia 43.12 36.89 6 1964 88 110587241
Retinal detachment 41.66 36.89 13 1957 11087 110576242
Eye irritation 40.63 36.89 17 1953 33435 110553894
Corneal abrasion 38.16 36.89 8 1962 1401 110585928
Presyncope 37.46 36.89 18 1952 48869 110538460

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01FA04 SENSORY ORGANS
OPHTHALMOLOGICALS
MYDRIATICS AND CYCLOPLEGICS
Anticholinergics
ATC S01FA54 SENSORY ORGANS
OPHTHALMOLOGICALS
MYDRIATICS AND CYCLOPLEGICS
Anticholinergics
MeSH PA D009184 Mydriatics
MeSH PA D010276 Parasympatholytics
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018678 Cholinergic Agents
MeSH PA D018680 Cholinergic Antagonists
MeSH PA D018727 Muscarinic Antagonists
CHEBI has role CHEBI:33295 diagnostic agent
CHEBI has role CHEBI:48876 muscarinic antagonist
CHEBI has role CHEBI:50370 parasympatholytic
CHEBI has role CHEBI:50513 mydriatic agent
CHEBI has role CHEBI:66981 ophthalmology drug

Related Drugs by ATC class:

S01FA Anticholinergics 5 drugs
atropinehomatropinemethscopolaminescopolaminetropicamide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Dilated pupil indication 37125009
Cycloplegia indication 68158006 DOID:10033
Perioperative Mydriasis indication
Uveitis off-label use 128473001 DOID:13141
Prevention of Posterior Synechiae off-label use
Brain damage contraindication 2470005
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Conduction disorder of the heart contraindication 44808001
Heart disease contraindication 56265001 DOID:114
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Spastic paralysis contraindication 78403003
Arterial aneurysm contraindication 233981004
Benign prostatic hyperplasia contraindication 266569009
Angle-closure glaucoma contraindication 392291006 DOID:13550
Disorder of coronary artery contraindication 414024009
Predisposition to Glaucoma contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Muscarinic acetylcholine receptor M3 GPCR ANTAGONIST CHEMBL CHEMBL

External reference:

IDSource
4019700 VUID
N0000147792 NUI
D01002 KEGG_DRUG
5870-29-1 SECONDARY_CAS_RN
106029 RXNORM
C0010582 UMLSCUI
CHEBI:4024 CHEBI
CHEMBL1201338 ChEMBL_ID
CHEMBL1200473 ChEMBL_ID
DB00979 DRUGBANK_ID
D003519 MESH_DESCRIPTOR_UI
2905 PUBCHEM_CID
7153 IUPHAR_LIGAND_ID
266 INN_ID
I76F4SHP7J UNII
225 MMSL
242 MMSL
39891 MMSL
4518 MMSL
001752 NDDF
004703 NDDF
372869004 SNOMEDCT_US
8348002 SNOMEDCT_US
83534009 SNOMEDCT_US
4018593 VANDF
4019700 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cyclomydril HUMAN PRESCRIPTION DRUG LABEL 2 0065-0359 SOLUTION/ DROPS 2 mg OPHTHALMIC ANDA 19 sections
Cyclogyl HUMAN PRESCRIPTION DRUG LABEL 1 0065-0395 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 20 sections
Cyclogyl HUMAN PRESCRIPTION DRUG LABEL 1 0065-0396 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 20 sections
Cyclogyl HUMAN PRESCRIPTION DRUG LABEL 1 0065-0397 SOLUTION/ DROPS 20 mg OPHTHALMIC ANDA 20 sections
Cyclopentolate HUMAN PRESCRIPTION DRUG LABEL 1 17478-096 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 12 sections
AK-PENTOLATE HUMAN PRESCRIPTION DRUG LABEL 1 21695-883 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 19 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 24208-735 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 20 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 42254-013 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 21 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-3234 SOLUTION 10 mg OPHTHALMIC ANDA 20 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-3874 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 20 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 54868-4697 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 21 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 61314-396 SOLUTION 10 mg OPHTHALMIC ANDA 20 sections