cyclopentolate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
757 512-15-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cyclopentolate
  • cyclopentolate hydrochloride
  • cyclogyl
  • cyclopentylate
  • cyclopentolate HCl
A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia.
  • Molecular weight: 291.39
  • Formula: C17H25NO3
  • CLOGP: 2.69
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 49.77
  • ALOGS: -2.29
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 31, 1974 FDA ALCON LABS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic anterior segment syndrome 200.86 45.67 35 889 2102 46683036
Corneal oedema 121.63 45.67 22 902 1624 46683514
Corneal epithelium defect 85.12 45.67 13 911 336 46684802
Anterior chamber cell 78.63 45.67 13 911 562 46684576
Endophthalmitis 77.89 45.67 17 907 3261 46681877
Keratopathy 71.62 45.67 11 913 295 46684843
Punctate keratitis 71.05 45.67 12 912 591 46684547
Iridocyclitis 68.30 45.67 14 910 1986 46683152
Mydriasis 62.60 45.67 18 906 10535 46674603
Visual acuity reduced 57.09 45.67 20 904 22093 46663045
Eye irritation 50.55 45.67 17 907 16597 46668541
Floppy iris syndrome 48.39 45.67 7 917 123 46685015
Corneal abrasion 47.31 45.67 9 915 869 46684269

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Floppy iris syndrome 85.13 50.28 13 633 308 29951524
Intraocular pressure increased 79.20 50.28 19 627 5101 29946731
Visual acuity reduced 70.33 50.28 22 624 15824 29936008
Keratopathy 59.68 50.28 9 637 195 29951637
Eye pain 54.92 50.28 17 629 11772 29940060

Pharmacologic Action:

SourceCodeDescription
ATC S01FA04 SENSORY ORGANS
OPHTHALMOLOGICALS
MYDRIATICS AND CYCLOPLEGICS
Anticholinergics
ATC S01FA54 SENSORY ORGANS
OPHTHALMOLOGICALS
MYDRIATICS AND CYCLOPLEGICS
Anticholinergics
CHEBI has role CHEBI:33295 diagnostic aid
CHEBI has role CHEBI:48876 antimuskarinika
CHEBI has role CHEBI:50370 parasympatholytics
CHEBI has role CHEBI:50513 mydriatics
MeSH PA D018678 Cholinergic Agents
MeSH PA D018680 Cholinergic Antagonists
MeSH PA D018727 Muscarinic Antagonists
MeSH PA D009184 Mydriatics
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D010276 Parasympatholytics
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Dilated pupil indication 37125009
Cycloplegia indication 68158006 DOID:10033
Perioperative Mydriasis indication
Uveitis off-label use 128473001 DOID:13141
Prevention of Posterior Synechiae off-label use
Brain damage contraindication 2470005
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Conduction disorder of the heart contraindication 44808001
Heart disease contraindication 56265001 DOID:114
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Spastic paralysis contraindication 78403003
Arterial aneurysm contraindication 233981004
Benign prostatic hyperplasia contraindication 266569009
Angle-closure glaucoma contraindication 392291006 DOID:13550
Disorder of coronary artery contraindication 414024009
Predisposition to Glaucoma contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M3 GPCR ANTAGONIST CHEMBL CHEMBL

External reference:

IDSource
4019700 VUID
N0000147792 NUI
D01002 KEGG_DRUG
5870-29-1 SECONDARY_CAS_RN
4018593 VANDF
4019700 VANDF
C0010563 UMLSCUI
CHEBI:4024 CHEBI
CHEMBL1200473 ChEMBL_ID
CHEMBL1201338 ChEMBL_ID
DB00979 DRUGBANK_ID
D003519 MESH_DESCRIPTOR_UI
2905 PUBCHEM_CID
7153 IUPHAR_LIGAND_ID
266 INN_ID
I76F4SHP7J UNII
106029 RXNORM
225 MMSL
242 MMSL
4518 MMSL
001752 NDDF
004703 NDDF
372869004 SNOMEDCT_US
8348002 SNOMEDCT_US
83534009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cyclomydril HUMAN PRESCRIPTION DRUG LABEL 2 0065-0359 SOLUTION/ DROPS 2 mg OPHTHALMIC ANDA 20 sections
Cyclogyl HUMAN PRESCRIPTION DRUG LABEL 1 0065-0395 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 20 sections
Cyclogyl HUMAN PRESCRIPTION DRUG LABEL 1 0065-0396 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 20 sections
Cyclogyl HUMAN PRESCRIPTION DRUG LABEL 1 0065-0397 SOLUTION/ DROPS 20 mg OPHTHALMIC ANDA 20 sections
Cyclopentolate Human Prescription Drug Label 1 17478-096 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 12 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 17478-097 SOLUTION/ DROPS 20 mg OPHTHALMIC ANDA 20 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 17478-100 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 20 sections
AK-PENTOLATE HUMAN PRESCRIPTION DRUG LABEL 1 21695-883 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 19 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 24208-735 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 20 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 42254-013 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 21 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-3234 SOLUTION 10 mg OPHTHALMIC ANDA 20 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-3874 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 20 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 54868-4697 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 21 sections
Cyclopentolate Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 61314-396 SOLUTION 10 mg OPHTHALMIC ANDA 20 sections