cyclopentolate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	757	512-15-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: cyclopentolate cyclopentolate hydrochloride cyclogyl cyclopentylate cyclopentolate HCl	A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia. Molecular weight: 291.39 Formula: C17H25NO3 CLOGP: 2.69 LIPINSKI: 0 HAC: 4 HDO: 1 TPSA: 49.77 ALOGS: -2.29 ROTB: 7 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

cyclopentolate
cyclopentolate hydrochloride
cyclogyl
cyclopentylate
cyclopentolate HCl

A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia.

Molecular weight: 291.39
Formula: C17H25NO3
CLOGP: 2.69
LIPINSKI: 0
HAC: 4
HDO: 1
TPSA: 49.77
ALOGS: -2.29
ROTB: 7

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
July 31, 1974	FDA	ALCON LABS INC

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Corneal oedema	126.53	47.48	22	1084	1471	63486445
Toxic anterior segment syndrome	96.82	47.48	18	1088	1753	63486163
Keratopathy	93.75	47.48	15	1091	601	63487315
Corneal epithelium defect	86.65	47.48	13	1093	339	63487577
Anterior chamber cell	81.00	47.48	13	1093	531	63487385
Punctate keratitis	72.21	47.48	12	1094	609	63487307
Visual acuity reduced	55.86	47.48	19	1087	21807	63466109
Hypopyon	50.08	47.48	9	1097	723	63487193
Floppy iris syndrome	49.72	47.48	7	1099	115	63487801
Mydriasis	49.46	47.48	15	1091	11941	63475975

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Mydriasis	56.27	47.16	15	624	7222	34949070
Toxic anterior segment syndrome	51.58	47.16	10	629	1159	34955133

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Corneal oedema	139.71	38.17	27	1701	2593	79740067
Toxic anterior segment syndrome	138.27	38.17	27	1701	2737	79739923
Keratopathy	133.35	38.17	23	1705	1171	79741489
Corneal epithelium defect	123.28	38.17	20	1708	699	79741961
Anterior chamber cell	97.30	38.17	17	1711	932	79741728
Punctate keratitis	89.99	38.17	16	1712	970	79741690
Mydriasis	88.54	38.17	27	1701	17616	79725044
Visual acuity reduced	78.72	38.17	28	1700	29441	79713219
Eye pain	72.08	38.17	28	1700	37550	79705110
Corneal opacity	69.97	38.17	13	1715	1007	79741653

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	S01FA04	SENSORY ORGANS OPHTHALMOLOGICALS MYDRIATICS AND CYCLOPLEGICS Anticholinergics
ATC	S01FA54	SENSORY ORGANS OPHTHALMOLOGICALS MYDRIATICS AND CYCLOPLEGICS Anticholinergics
CHEBI has role	CHEBI:33295	diagnostic aid
CHEBI has role	CHEBI:48876	muscarinic antagonists
CHEBI has role	CHEBI:50370	parasympatholytics
CHEBI has role	CHEBI:50513	mydriatics
MeSH PA	D018678	Cholinergic Agents
MeSH PA	D018680	Cholinergic Antagonists
MeSH PA	D018727	Muscarinic Antagonists
MeSH PA	D009184	Mydriatics

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Dilated pupil	indication	37125009
Cycloplegia	indication	68158006	DOID:10033
Perioperative Mydriasis	indication
Uveitis	off-label use	128473001	DOID:13141
Prevention of Posterior Synechiae	off-label use
Brain damage	contraindication	2470005
Hyperthyroidism	contraindication	34486009	DOID:7998
Hypertensive disorder	contraindication	38341003	DOID:10763
Complete trisomy 21 syndrome	contraindication	41040004	DOID:14250
Conduction disorder of the heart	contraindication	44808001

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.23	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN	ANTAGONIST				CHEMBL	CHEMBL

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External reference:

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ID	Source
001752	NDDF
004703	NDDF
106029	RXNORM
225	MMSL
242	MMSL
266	INN_ID
2905	PUBCHEM_CID
372869004	SNOMEDCT_US
39891	MMSL
4018593	VANDF

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
AK-PENTOLATE	HUMAN PRESCRIPTION DRUG LABEL	1	21695-883	SOLUTION/ DROPS	10 mg	OPHTHALMIC	ANDA	19 sections
Cyclogyl	HUMAN PRESCRIPTION DRUG LABEL	1	0065-0395	SOLUTION/ DROPS	5 mg	OPHTHALMIC	ANDA	20 sections
Cyclogyl	HUMAN PRESCRIPTION DRUG LABEL	1	0065-0395	SOLUTION/ DROPS	5 mg	OPHTHALMIC	ANDA	20 sections
Cyclogyl	HUMAN PRESCRIPTION DRUG LABEL	1	0065-0396	SOLUTION/ DROPS	10 mg	OPHTHALMIC	ANDA	20 sections
Cyclogyl	HUMAN PRESCRIPTION DRUG LABEL	1	0065-0396	SOLUTION/ DROPS	10 mg	OPHTHALMIC	ANDA	20 sections
Cyclogyl	HUMAN PRESCRIPTION DRUG LABEL	1	0065-0397	SOLUTION/ DROPS	20 mg	OPHTHALMIC	ANDA	20 sections
Cyclogyl	HUMAN PRESCRIPTION DRUG LABEL	1	0065-0397	SOLUTION/ DROPS	20 mg	OPHTHALMIC	ANDA	20 sections
Cyclomydril	HUMAN PRESCRIPTION DRUG LABEL	2	0065-0359	SOLUTION/ DROPS	2 mg	OPHTHALMIC	ANDA	20 sections
Cyclomydril	HUMAN PRESCRIPTION DRUG LABEL	2	0065-0359	SOLUTION/ DROPS	2 mg	OPHTHALMIC	ANDA	20 sections
Cyclopentolate	HUMAN PRESCRIPTION DRUG LABEL	1	17478-096	SOLUTION/ DROPS	5 mg	OPHTHALMIC	ANDA	12 sections

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