Stem definition | Drug id | CAS RN |
---|---|---|
751 | 303-53-7 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 200 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 1.37 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 55 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 26, 1977 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1010.68 | 10.96 | 1107 | 74131 | 130782 | 50399104 |
Toxicity to various agents | 621.51 | 10.96 | 1123 | 74115 | 211376 | 50318510 |
Drug abuse | 458.42 | 10.96 | 503 | 74735 | 59343 | 50470543 |
Sedation complication | 434.98 | 10.96 | 227 | 75011 | 8539 | 50521347 |
Sedation | 391.85 | 10.96 | 341 | 74897 | 30269 | 50499617 |
Creatinine renal clearance decreased | 378.27 | 10.96 | 230 | 75008 | 11651 | 50518235 |
Orthostatic hypotension | 323.23 | 10.96 | 301 | 74937 | 29180 | 50500706 |
Cognitive disorder | 292.14 | 10.96 | 344 | 74894 | 43779 | 50486107 |
Temperature regulation disorder | 285.46 | 10.96 | 135 | 75103 | 4092 | 50525794 |
Blood calcium decreased | 279.84 | 10.96 | 238 | 75000 | 20468 | 50509418 |
Constipation | 270.07 | 10.96 | 743 | 74495 | 184965 | 50344921 |
Balance disorder | 230.07 | 10.96 | 392 | 74846 | 70198 | 50459688 |
Food allergy | 212.57 | 10.96 | 139 | 75099 | 7998 | 50521888 |
Depressed level of consciousness | 206.80 | 10.96 | 316 | 74922 | 51637 | 50478249 |
Coeliac disease | 197.22 | 10.96 | 136 | 75102 | 8549 | 50521337 |
Respiratory arrest | 180.65 | 10.96 | 223 | 75015 | 29786 | 50500100 |
Immunodeficiency | 171.42 | 10.96 | 156 | 75082 | 14672 | 50515214 |
Cardio-respiratory arrest | 162.16 | 10.96 | 289 | 74949 | 53603 | 50476283 |
Bursitis | 148.80 | 10.96 | 174 | 75064 | 21961 | 50507925 |
Pain | 139.32 | 10.96 | 1391 | 73847 | 577512 | 49952374 |
Maternal exposure during pregnancy | 135.80 | 10.96 | 35 | 75203 | 159743 | 50370143 |
Hyperhidrosis | 123.01 | 10.96 | 351 | 74887 | 89075 | 50440811 |
Glossodynia | 122.89 | 10.96 | 14 | 75224 | 115555 | 50414331 |
Mobility decreased | 121.05 | 10.96 | 325 | 74913 | 79623 | 50450263 |
Drug hypersensitivity | 119.96 | 10.96 | 709 | 74529 | 250301 | 50279585 |
Systemic lupus erythematosus | 115.36 | 10.96 | 33 | 75205 | 140589 | 50389297 |
Hand deformity | 112.09 | 10.96 | 10 | 75228 | 100189 | 50429697 |
Synovitis | 109.40 | 10.96 | 25 | 75213 | 123840 | 50406046 |
Back pain | 107.34 | 10.96 | 625 | 74613 | 219405 | 50310481 |
Fall | 103.30 | 10.96 | 850 | 74388 | 334082 | 50195804 |
Anti-cyclic citrullinated peptide antibody positive | 91.35 | 10.96 | 3 | 75235 | 70584 | 50459302 |
Fluid retention | 91.31 | 10.96 | 220 | 75018 | 50429 | 50479457 |
Migraine | 90.71 | 10.96 | 282 | 74956 | 74998 | 50454888 |
Pericarditis | 87.61 | 10.96 | 8 | 75230 | 78681 | 50451205 |
Upper respiratory tract infection | 86.10 | 10.96 | 254 | 74984 | 65644 | 50464242 |
Product dose omission issue | 84.34 | 10.96 | 514 | 74724 | 183324 | 50346562 |
Cardiac arrest | 79.23 | 10.96 | 289 | 74949 | 83362 | 50446524 |
Poisoning | 74.19 | 10.96 | 92 | 75146 | 12337 | 50517549 |
Lower respiratory tract infection | 73.29 | 10.96 | 25 | 75213 | 95176 | 50434710 |
Rash erythematous | 72.29 | 10.96 | 160 | 75078 | 34692 | 50495194 |
Decorticate posture | 71.87 | 10.96 | 24 | 75214 | 279 | 50529607 |
Exposure during pregnancy | 71.30 | 10.96 | 46 | 75192 | 120969 | 50408917 |
Anxiety | 68.84 | 10.96 | 476 | 74762 | 177130 | 50352756 |
Hyponatraemia | 66.19 | 10.96 | 30 | 75208 | 96109 | 50433777 |
Asthma | 64.04 | 10.96 | 283 | 74955 | 89054 | 50440832 |
Pulmonary malformation | 63.79 | 10.96 | 20 | 75218 | 187 | 50529699 |
Wound | 61.26 | 10.96 | 41 | 75197 | 105753 | 50424133 |
Intentional product misuse | 60.90 | 10.96 | 180 | 75058 | 46554 | 50483332 |
Headache | 58.51 | 10.96 | 1067 | 74171 | 505468 | 50024418 |
Fibromyalgia | 56.49 | 10.96 | 171 | 75067 | 44807 | 50485079 |
Hypotension | 54.87 | 10.96 | 563 | 74675 | 234906 | 50294980 |
Neutropenia | 54.28 | 10.96 | 85 | 75153 | 147880 | 50382006 |
Drug ineffective | 53.44 | 10.96 | 878 | 74360 | 818455 | 49711431 |
Respiratory depression | 51.96 | 10.96 | 76 | 75162 | 11934 | 50517952 |
Alopecia | 51.49 | 10.96 | 189 | 75049 | 244858 | 50285028 |
Therapeutic product effect decreased | 51.01 | 10.96 | 77 | 75161 | 135973 | 50393913 |
Memory impairment | 50.65 | 10.96 | 243 | 74995 | 79117 | 50450769 |
Psoriasis | 49.00 | 10.96 | 218 | 75020 | 68782 | 50461104 |
Febrile neutropenia | 48.74 | 10.96 | 44 | 75194 | 97623 | 50432263 |
Discomfort | 47.09 | 10.96 | 55 | 75183 | 108325 | 50421561 |
Leukopenia | 46.58 | 10.96 | 21 | 75217 | 67507 | 50462379 |
Thrombocytopenia | 46.20 | 10.96 | 74 | 75164 | 127599 | 50402287 |
Pancytopenia | 45.45 | 10.96 | 35 | 75203 | 83995 | 50445891 |
Cardiac failure | 44.64 | 10.96 | 29 | 75209 | 76011 | 50453875 |
Joint swelling | 42.94 | 10.96 | 203 | 75035 | 245083 | 50284803 |
Pyrexia | 42.22 | 10.96 | 362 | 74876 | 379841 | 50150045 |
Lung cyst | 42.14 | 10.96 | 14 | 75224 | 160 | 50529726 |
Myocardial depression | 41.93 | 10.96 | 18 | 75220 | 432 | 50529454 |
Spinal operation | 41.71 | 10.96 | 49 | 75189 | 6211 | 50523675 |
Infusion related reaction | 41.66 | 10.96 | 122 | 75116 | 169435 | 50360451 |
Acute kidney injury | 40.35 | 10.96 | 188 | 75050 | 227870 | 50302016 |
Anaemia | 39.61 | 10.96 | 217 | 75021 | 252239 | 50277647 |
C-reactive protein increased | 39.50 | 10.96 | 25 | 75213 | 66449 | 50463437 |
Suspected suicide | 39.18 | 10.96 | 44 | 75194 | 5313 | 50524573 |
Post-traumatic neck syndrome | 38.92 | 10.96 | 28 | 75210 | 1882 | 50528004 |
Muscle injury | 38.19 | 10.96 | 5 | 75233 | 37106 | 50492780 |
Blepharospasm | 38.01 | 10.96 | 33 | 75205 | 2915 | 50526971 |
Muscle spasms | 37.13 | 10.96 | 316 | 74922 | 125237 | 50404649 |
Arthropathy | 36.38 | 10.96 | 117 | 75121 | 157789 | 50372097 |
Contraindicated product administered | 35.28 | 10.96 | 109 | 75129 | 148849 | 50381037 |
Alanine aminotransferase increased | 35.09 | 10.96 | 48 | 75190 | 88311 | 50441575 |
Depression | 34.97 | 10.96 | 388 | 74850 | 165035 | 50364851 |
General physical health deterioration | 34.61 | 10.96 | 103 | 75135 | 142331 | 50387555 |
Treatment failure | 34.56 | 10.96 | 98 | 75140 | 137539 | 50392347 |
Gastrointestinal disorder | 33.00 | 10.96 | 56 | 75182 | 94400 | 50435486 |
Electrocardiogram QT prolonged | 32.97 | 10.96 | 18 | 75220 | 51868 | 50478018 |
Respiratory tract malformation | 32.54 | 10.96 | 10 | 75228 | 87 | 50529799 |
Libido increased | 31.89 | 10.96 | 21 | 75217 | 1222 | 50528664 |
Hyperkalaemia | 31.57 | 10.96 | 16 | 75222 | 48073 | 50481813 |
Therapy interrupted | 31.55 | 10.96 | 83 | 75155 | 20069 | 50509817 |
Hostility | 31.54 | 10.96 | 24 | 75214 | 1758 | 50528128 |
Exposure via ingestion | 31.43 | 10.96 | 29 | 75209 | 2774 | 50527112 |
Renal impairment | 31.17 | 10.96 | 40 | 75198 | 75621 | 50454265 |
Pre-existing condition improved | 30.83 | 10.96 | 45 | 75193 | 7052 | 50522834 |
Taste disorder | 30.81 | 10.96 | 49 | 75189 | 8275 | 50521611 |
Soft tissue injury | 30.80 | 10.96 | 22 | 75216 | 1462 | 50528424 |
Off label use | 29.90 | 10.96 | 511 | 74727 | 473915 | 50055971 |
Dysphoria | 29.56 | 10.96 | 36 | 75202 | 4738 | 50525148 |
Malignant neoplasm progression | 29.12 | 10.96 | 35 | 75203 | 68089 | 50461797 |
Folliculitis | 28.99 | 10.96 | 11 | 75227 | 39214 | 50490672 |
International normalised ratio increased | 27.37 | 10.96 | 15 | 75223 | 43137 | 50486749 |
Therapy cessation | 27.30 | 10.96 | 93 | 75145 | 25918 | 50503968 |
Hypoaesthesia | 27.11 | 10.96 | 299 | 74939 | 126958 | 50402928 |
Swelling | 27.10 | 10.96 | 181 | 75057 | 200691 | 50329195 |
Sternal fracture | 27.01 | 10.96 | 23 | 75215 | 1979 | 50527907 |
Intervertebral disc protrusion | 26.99 | 10.96 | 79 | 75159 | 20314 | 50509572 |
Blood creatinine increased | 26.74 | 10.96 | 45 | 75193 | 76115 | 50453771 |
Unresponsive to stimuli | 26.66 | 10.96 | 103 | 75135 | 30506 | 50499380 |
Bronchitis | 26.61 | 10.96 | 254 | 74984 | 103905 | 50425981 |
Surgery | 26.61 | 10.96 | 102 | 75136 | 30103 | 50499783 |
Aspartate aminotransferase increased | 26.55 | 10.96 | 47 | 75191 | 77951 | 50451935 |
Gamma-glutamyltransferase increased | 26.09 | 10.96 | 6 | 75232 | 29617 | 50500269 |
Drug intolerance | 25.91 | 10.96 | 205 | 75033 | 218899 | 50310987 |
Abdominal discomfort | 25.90 | 10.96 | 220 | 75018 | 231421 | 50298465 |
Mucosal inflammation | 25.40 | 10.96 | 14 | 75224 | 40128 | 50489758 |
Pleural effusion | 25.17 | 10.96 | 52 | 75186 | 81402 | 50448484 |
Back disorder | 24.32 | 10.96 | 47 | 75191 | 9258 | 50520628 |
Hypokalaemia | 24.09 | 10.96 | 60 | 75178 | 87932 | 50441954 |
Neck pain | 23.89 | 10.96 | 156 | 75082 | 56911 | 50472975 |
Rash | 23.87 | 10.96 | 483 | 74755 | 436988 | 50092898 |
Urinary incontinence | 23.82 | 10.96 | 94 | 75144 | 28114 | 50501772 |
Impaired healing | 23.80 | 10.96 | 42 | 75196 | 69744 | 50460142 |
Lactation disorder | 23.57 | 10.96 | 11 | 75227 | 323 | 50529563 |
Bone marrow failure | 23.54 | 10.96 | 6 | 75232 | 27618 | 50502268 |
Concussion | 23.04 | 10.96 | 41 | 75197 | 7587 | 50522299 |
Drug interaction | 22.58 | 10.96 | 189 | 75049 | 199432 | 50330454 |
Fracture pain | 22.50 | 10.96 | 11 | 75227 | 359 | 50529527 |
Drug-induced liver injury | 22.28 | 10.96 | 7 | 75231 | 28088 | 50501798 |
Gluten sensitivity | 22.12 | 10.96 | 12 | 75226 | 488 | 50529398 |
Irritability | 21.84 | 10.96 | 92 | 75146 | 28334 | 50501552 |
Meniscus injury | 21.83 | 10.96 | 36 | 75202 | 6266 | 50523620 |
Infection | 21.77 | 10.96 | 159 | 75079 | 172795 | 50357091 |
Atrial fibrillation | 21.64 | 10.96 | 78 | 75160 | 101667 | 50428219 |
Paranasal cyst | 21.61 | 10.96 | 10 | 75228 | 288 | 50529598 |
Vascular malformation | 21.45 | 10.96 | 10 | 75228 | 293 | 50529593 |
Device expulsion | 21.43 | 10.96 | 8 | 75230 | 28814 | 50501072 |
Erythema | 21.43 | 10.96 | 321 | 74917 | 146093 | 50383793 |
Decreased appetite | 21.06 | 10.96 | 194 | 75044 | 200729 | 50329157 |
Stomatitis | 20.70 | 10.96 | 79 | 75159 | 101265 | 50428621 |
Stress | 20.69 | 10.96 | 144 | 75094 | 53649 | 50476237 |
Ascites | 20.61 | 10.96 | 14 | 75224 | 35847 | 50494039 |
Jaundice | 20.23 | 10.96 | 7 | 75231 | 26422 | 50503464 |
Injury | 20.02 | 10.96 | 133 | 75105 | 48792 | 50481094 |
Serum sickness-like reaction | 20.00 | 10.96 | 11 | 75227 | 460 | 50529426 |
Blood alkaline phosphatase increased | 19.82 | 10.96 | 16 | 75222 | 37510 | 50492376 |
Hepatic function abnormal | 19.82 | 10.96 | 12 | 75226 | 32669 | 50497217 |
Abortion spontaneous | 19.46 | 10.96 | 20 | 75218 | 41752 | 50488134 |
Paraesthesia | 19.33 | 10.96 | 268 | 74970 | 119975 | 50409911 |
Blood lactate dehydrogenase increased | 19.27 | 10.96 | 3 | 75235 | 19559 | 50510327 |
Emotional distress | 19.17 | 10.96 | 89 | 75149 | 28574 | 50501312 |
Dyspnoea | 18.89 | 10.96 | 646 | 74592 | 546962 | 49982924 |
Poor quality sleep | 18.79 | 10.96 | 61 | 75177 | 16585 | 50513301 |
Muscle twitching | 18.74 | 10.96 | 58 | 75180 | 15373 | 50514513 |
Exposure via breast milk | 18.74 | 10.96 | 17 | 75221 | 1591 | 50528295 |
Psoriatic arthropathy | 18.74 | 10.96 | 127 | 75111 | 46905 | 50482981 |
Hyperaesthesia | 18.64 | 10.96 | 39 | 75199 | 8134 | 50521752 |
Drug resistance | 18.51 | 10.96 | 3 | 75235 | 18986 | 50510900 |
Feeling abnormal | 18.31 | 10.96 | 275 | 74963 | 125217 | 50404669 |
Interstitial lung disease | 18.13 | 10.96 | 32 | 75206 | 53144 | 50476742 |
Blister | 17.82 | 10.96 | 66 | 75172 | 85352 | 50444534 |
Blood bilirubin increased | 17.76 | 10.96 | 13 | 75225 | 32025 | 50497861 |
Maternal exposure during breast feeding | 17.70 | 10.96 | 23 | 75215 | 3231 | 50526655 |
Liver function test abnormal | 17.68 | 10.96 | 24 | 75214 | 44315 | 50485571 |
Uterine perforation | 17.50 | 10.96 | 33 | 75205 | 6382 | 50523504 |
Road traffic accident | 17.32 | 10.96 | 77 | 75161 | 24275 | 50505611 |
Nightmare | 17.31 | 10.96 | 58 | 75180 | 16028 | 50513858 |
Infrequent bowel movements | 17.28 | 10.96 | 14 | 75224 | 1124 | 50528762 |
Insomnia | 17.23 | 10.96 | 360 | 74878 | 174505 | 50355381 |
Liver disorder | 17.13 | 10.96 | 18 | 75220 | 37204 | 50492682 |
Withdrawal syndrome | 16.82 | 10.96 | 61 | 75177 | 17529 | 50512357 |
Drug eruption | 16.82 | 10.96 | 7 | 75231 | 23599 | 50506287 |
Personality disorder | 16.76 | 10.96 | 26 | 75212 | 4298 | 50525588 |
Lymphatic system neoplasm | 16.75 | 10.96 | 5 | 75233 | 39 | 50529847 |
Lactic acidosis | 16.66 | 10.96 | 15 | 75223 | 33340 | 50496546 |
Electrocardiogram QRS complex prolonged | 16.50 | 10.96 | 29 | 75209 | 5315 | 50524571 |
Mastoiditis | 16.43 | 10.96 | 12 | 75226 | 826 | 50529060 |
Multiple sclerosis | 16.27 | 10.96 | 67 | 75171 | 20426 | 50509460 |
Confusional state | 16.01 | 10.96 | 188 | 75050 | 185740 | 50344146 |
Dry mouth | 15.86 | 10.96 | 140 | 75098 | 56038 | 50473848 |
Agranulocytosis | 15.84 | 10.96 | 6 | 75232 | 21415 | 50508471 |
Cardiac failure congestive | 15.83 | 10.96 | 68 | 75170 | 84314 | 50445572 |
Platelet count decreased | 15.53 | 10.96 | 87 | 75151 | 100639 | 50429247 |
Sepsis | 15.40 | 10.96 | 125 | 75113 | 132800 | 50397086 |
Suicidal ideation | 15.11 | 10.96 | 137 | 75101 | 55248 | 50474638 |
Gastrooesophageal reflux disease | 15.10 | 10.96 | 177 | 75061 | 76251 | 50453635 |
Lower limb fracture | 15.00 | 10.96 | 51 | 75187 | 14195 | 50515691 |
Intervertebral disc degeneration | 14.90 | 10.96 | 49 | 75189 | 13412 | 50516474 |
Melaena | 14.76 | 10.96 | 11 | 75227 | 26853 | 50503033 |
Oedema peripheral | 14.67 | 10.96 | 157 | 75081 | 157804 | 50372082 |
Stevens-Johnson syndrome | 14.63 | 10.96 | 7 | 75231 | 21745 | 50508141 |
Rib fracture | 14.61 | 10.96 | 62 | 75176 | 19159 | 50510727 |
Overdose | 14.33 | 10.96 | 218 | 75020 | 99509 | 50430377 |
Cholecystitis chronic | 14.30 | 10.96 | 39 | 75199 | 9630 | 50520256 |
Circulatory collapse | 14.14 | 10.96 | 6 | 75232 | 19994 | 50509892 |
Disseminated intravascular coagulation | 14.07 | 10.96 | 4 | 75234 | 17131 | 50512755 |
Somnolence | 13.96 | 10.96 | 315 | 74923 | 154670 | 50375216 |
Premature delivery | 13.92 | 10.96 | 9 | 75229 | 23654 | 50506232 |
Peritonitis | 13.91 | 10.96 | 3 | 75235 | 15483 | 50514403 |
Therapy non-responder | 13.80 | 10.96 | 35 | 75203 | 50987 | 50478899 |
Exposure via inhalation | 13.78 | 10.96 | 4 | 75234 | 28 | 50529858 |
Neutrophil count decreased | 13.70 | 10.96 | 30 | 75208 | 45996 | 50483890 |
Hypoglycaemia | 13.55 | 10.96 | 38 | 75200 | 53543 | 50476343 |
Multiple organ dysfunction syndrome | 13.25 | 10.96 | 35 | 75203 | 50302 | 50479584 |
Haematemesis | 13.22 | 10.96 | 13 | 75225 | 27712 | 50502174 |
Cholestasis | 13.20 | 10.96 | 11 | 75227 | 25390 | 50504496 |
Foot fracture | 13.15 | 10.96 | 62 | 75176 | 20029 | 50509857 |
Muscle strain | 12.99 | 10.96 | 31 | 75207 | 7057 | 50522829 |
Neurotoxicity | 12.95 | 10.96 | 3 | 75235 | 14737 | 50515149 |
Muscle neoplasm | 12.89 | 10.96 | 4 | 75234 | 36 | 50529850 |
Pregnancy | 12.85 | 10.96 | 15 | 75223 | 29562 | 50500324 |
Rotator cuff syndrome | 12.75 | 10.96 | 42 | 75196 | 11502 | 50518384 |
Knee arthroplasty | 12.74 | 10.96 | 21 | 75217 | 35825 | 50494061 |
Middle insomnia | 12.71 | 10.96 | 38 | 75200 | 9883 | 50520003 |
Irritable bowel syndrome | 12.63 | 10.96 | 37 | 75201 | 51404 | 50478482 |
Gallbladder neoplasm | 12.61 | 10.96 | 4 | 75234 | 39 | 50529847 |
Angioedema | 12.55 | 10.96 | 23 | 75215 | 37653 | 50492233 |
Product use issue | 12.53 | 10.96 | 152 | 75086 | 149323 | 50380563 |
Sleep apnoea syndrome | 12.38 | 10.96 | 69 | 75169 | 23799 | 50506087 |
Congenital cystic lung | 12.34 | 10.96 | 4 | 75234 | 42 | 50529844 |
Hypothyroidism | 12.33 | 10.96 | 90 | 75148 | 34035 | 50495851 |
Hypocalcaemia | 12.31 | 10.96 | 13 | 75225 | 26803 | 50503083 |
Transaminases increased | 12.21 | 10.96 | 14 | 75224 | 27810 | 50502076 |
Lymphopenia | 12.19 | 10.96 | 4 | 75234 | 15617 | 50514269 |
Rash maculo-papular | 12.13 | 10.96 | 13 | 75225 | 26628 | 50503258 |
Gastrointestinal haemorrhage | 12.04 | 10.96 | 62 | 75176 | 73259 | 50456627 |
Bradycardia | 12.03 | 10.96 | 52 | 75186 | 64374 | 50465512 |
Altered state of consciousness | 12.00 | 10.96 | 9 | 75229 | 21901 | 50507985 |
Back injury | 11.94 | 10.96 | 30 | 75208 | 7055 | 50522831 |
Anticholinergic syndrome | 11.87 | 10.96 | 14 | 75224 | 1781 | 50528105 |
Syncope | 11.87 | 10.96 | 97 | 75141 | 102905 | 50426981 |
Respiratory acidosis | 11.74 | 10.96 | 27 | 75211 | 6001 | 50523885 |
Tubulointerstitial nephritis | 11.69 | 10.96 | 4 | 75234 | 15207 | 50514679 |
Fatigue | 11.62 | 10.96 | 1211 | 74027 | 706390 | 49823496 |
Hip arthroplasty | 11.61 | 10.96 | 17 | 75221 | 30412 | 50499474 |
Multiple sclerosis relapse | 11.58 | 10.96 | 106 | 75132 | 42858 | 50487028 |
Injection site mass | 11.47 | 10.96 | 50 | 75188 | 15630 | 50514256 |
Liver injury | 11.41 | 10.96 | 12 | 75226 | 24794 | 50505092 |
Drug withdrawal syndrome | 11.38 | 10.96 | 70 | 75168 | 25011 | 50504875 |
Myalgia | 11.29 | 10.96 | 253 | 74985 | 124066 | 50405820 |
Bladder discomfort | 11.26 | 10.96 | 8 | 75230 | 527 | 50529359 |
Body height increased | 11.24 | 10.96 | 4 | 75234 | 57 | 50529829 |
Tenderness | 11.23 | 10.96 | 56 | 75182 | 18509 | 50511377 |
Copper deficiency | 11.17 | 10.96 | 4 | 75234 | 58 | 50529828 |
Upper gastrointestinal haemorrhage | 11.03 | 10.96 | 5 | 75233 | 16030 | 50513856 |
Rheumatoid arthritis | 11.02 | 10.96 | 386 | 74852 | 202164 | 50327722 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 512.08 | 13.28 | 464 | 21086 | 89782 | 29463195 |
Drug abuse | 278.34 | 13.28 | 316 | 21234 | 79567 | 29473410 |
Toxicity to various agents | 216.08 | 13.28 | 423 | 21127 | 173238 | 29379739 |
Respiratory arrest | 103.21 | 13.28 | 110 | 21440 | 25723 | 29527254 |
Cardio-respiratory arrest | 61.02 | 13.28 | 122 | 21428 | 50479 | 29502498 |
Milk-alkali syndrome | 59.64 | 13.28 | 20 | 21530 | 502 | 29552475 |
Intentional product misuse | 57.56 | 13.28 | 96 | 21454 | 34565 | 29518412 |
Product dose omission issue | 53.44 | 13.28 | 173 | 21377 | 96210 | 29456767 |
Back pain | 46.59 | 13.28 | 172 | 21378 | 102112 | 29450865 |
General physical health deterioration | 42.94 | 13.28 | 11 | 21539 | 102846 | 29450131 |
Back disorder | 42.34 | 13.28 | 35 | 21515 | 5938 | 29547039 |
Spinal operation | 35.35 | 13.28 | 22 | 21528 | 2392 | 29550585 |
Lymphocyte count abnormal | 34.38 | 13.28 | 14 | 21536 | 613 | 29552364 |
Interstitial lung disease | 31.17 | 13.28 | 3 | 21547 | 57715 | 29495262 |
Pain | 29.64 | 13.28 | 220 | 21330 | 171212 | 29381765 |
Back injury | 28.05 | 13.28 | 22 | 21528 | 3462 | 29549515 |
Death | 27.38 | 13.28 | 374 | 21176 | 341710 | 29211267 |
Suspected suicide | 27.34 | 13.28 | 23 | 21527 | 3997 | 29548980 |
Cardiac arrest | 27.22 | 13.28 | 129 | 21421 | 85462 | 29467515 |
Serotonin syndrome | 27.07 | 13.28 | 47 | 21503 | 17465 | 29535512 |
Thrombocytopenia | 26.19 | 13.28 | 36 | 21514 | 134787 | 29418190 |
Drug hypersensitivity | 25.43 | 13.28 | 108 | 21442 | 68298 | 29484679 |
Leukopenia | 24.83 | 13.28 | 5 | 21545 | 55198 | 29497779 |
Ankylosing spondylitis | 24.57 | 13.28 | 22 | 21528 | 4154 | 29548823 |
Overdose | 23.73 | 13.28 | 118 | 21432 | 79701 | 29473276 |
Spinal fracture | 23.07 | 13.28 | 26 | 21524 | 6460 | 29546517 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 22.67 | 13.28 | 11 | 21539 | 732 | 29552245 |
C-reactive protein increased | 22.15 | 13.28 | 3 | 21547 | 44260 | 29508717 |
Anaemia | 21.37 | 13.28 | 75 | 21475 | 200876 | 29352101 |
Exposure via ingestion | 21.31 | 13.28 | 15 | 21535 | 2003 | 29550974 |
Poisoning | 21.20 | 13.28 | 31 | 21519 | 9962 | 29543015 |
Product use in unapproved indication | 20.30 | 13.28 | 20 | 21530 | 86855 | 29466122 |
Anion gap | 19.80 | 13.28 | 10 | 21540 | 726 | 29552251 |
Arthralgia | 19.65 | 13.28 | 171 | 21379 | 139446 | 29413531 |
Peripheral swelling | 18.77 | 13.28 | 94 | 21456 | 63645 | 29489332 |
Bronchial hyperreactivity | 18.56 | 13.28 | 12 | 21538 | 1394 | 29551583 |
Cardiac failure | 17.68 | 13.28 | 19 | 21531 | 79268 | 29473709 |
Metabolic alkalosis | 17.43 | 13.28 | 11 | 21539 | 1225 | 29551752 |
Feeling abnormal | 17.25 | 13.28 | 82 | 21468 | 54363 | 29498614 |
Blood creatinine increased | 17.25 | 13.28 | 22 | 21528 | 85080 | 29467897 |
Muscle spasms | 17.11 | 13.28 | 93 | 21457 | 64989 | 29487988 |
Hyponatraemia | 16.47 | 13.28 | 15 | 21535 | 67618 | 29485359 |
Accidental poisoning | 16.24 | 13.28 | 8 | 21542 | 550 | 29552427 |
Adverse drug reaction | 15.97 | 13.28 | 46 | 21504 | 23974 | 29529003 |
Respiratory failure | 15.94 | 13.28 | 29 | 21521 | 97102 | 29455875 |
Intervertebral disc protrusion | 15.71 | 13.28 | 25 | 21525 | 8645 | 29544332 |
Unresponsive to stimuli | 15.64 | 13.28 | 47 | 21503 | 25079 | 29527898 |
Vasoplegia syndrome | 15.44 | 13.28 | 11 | 21539 | 1497 | 29551480 |
Psoriasis | 15.31 | 13.28 | 55 | 21495 | 32172 | 29520805 |
Neck pain | 15.17 | 13.28 | 42 | 21508 | 21405 | 29531572 |
Hepatic function abnormal | 14.90 | 13.28 | 5 | 21545 | 39254 | 29513723 |
Pain in extremity | 14.87 | 13.28 | 134 | 21416 | 110299 | 29442678 |
Insomnia | 14.78 | 13.28 | 113 | 21437 | 88648 | 29464329 |
Irritable bowel syndrome | 14.59 | 13.28 | 14 | 21536 | 2887 | 29550090 |
Anion gap abnormal | 14.32 | 13.28 | 5 | 21545 | 142 | 29552835 |
Painful ejaculation | 13.73 | 13.28 | 4 | 21546 | 62 | 29552915 |
Melaena | 13.65 | 13.28 | 3 | 21547 | 31173 | 29521804 |
Ascites | 13.32 | 13.28 | 5 | 21545 | 36614 | 29516363 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1482.99 | 10.79 | 1586 | 77212 | 222828 | 64197106 |
Toxicity to various agents | 791.81 | 10.79 | 1512 | 77286 | 362001 | 64057933 |
Drug abuse | 664.31 | 10.79 | 813 | 77985 | 131561 | 64288373 |
Sedation complication | 485.20 | 10.79 | 242 | 78556 | 10112 | 64409822 |
Creatinine renal clearance decreased | 420.51 | 10.79 | 246 | 78552 | 14175 | 64405759 |
Sedation | 399.22 | 10.79 | 361 | 78437 | 41101 | 64378833 |
Cognitive disorder | 313.23 | 10.79 | 361 | 78437 | 54726 | 64365208 |
Blood calcium decreased | 309.99 | 10.79 | 254 | 78544 | 25300 | 64394634 |
Temperature regulation disorder | 304.82 | 10.79 | 133 | 78665 | 4078 | 64415856 |
Orthostatic hypotension | 292.53 | 10.79 | 322 | 78476 | 46416 | 64373518 |
Constipation | 270.07 | 10.79 | 750 | 78048 | 228587 | 64191347 |
Balance disorder | 258.61 | 10.79 | 408 | 78390 | 83518 | 64336416 |
Pain | 253.41 | 10.79 | 1337 | 77461 | 552174 | 63867760 |
Respiratory arrest | 251.74 | 10.79 | 317 | 78481 | 52668 | 64367266 |
Coeliac disease | 233.53 | 10.79 | 133 | 78665 | 7279 | 64412655 |
Food allergy | 231.68 | 10.79 | 135 | 78663 | 7716 | 64412218 |
Cardio-respiratory arrest | 212.56 | 10.79 | 409 | 78389 | 97984 | 64321950 |
Depressed level of consciousness | 209.38 | 10.79 | 365 | 78433 | 81071 | 64338863 |
Immunodeficiency | 172.29 | 10.79 | 149 | 78649 | 15975 | 64403959 |
Bursitis | 172.11 | 10.79 | 169 | 78629 | 21316 | 64398618 |
Mobility decreased | 161.61 | 10.79 | 337 | 78461 | 85503 | 64334431 |
Drug hypersensitivity | 132.90 | 10.79 | 609 | 78189 | 237206 | 64182728 |
Back pain | 131.28 | 10.79 | 629 | 78169 | 249542 | 64170392 |
Intentional product misuse | 119.12 | 10.79 | 269 | 78529 | 72026 | 64347908 |
Migraine | 109.78 | 10.79 | 239 | 78559 | 62438 | 64357496 |
Fall | 97.53 | 10.79 | 854 | 77944 | 415972 | 64003962 |
Fluid retention | 97.31 | 10.79 | 221 | 78577 | 59385 | 64360549 |
Cardiac arrest | 94.63 | 10.79 | 406 | 78392 | 153658 | 64266276 |
Poisoning | 88.50 | 10.79 | 121 | 78677 | 21758 | 64398176 |
Product dose omission issue | 88.24 | 10.79 | 470 | 78328 | 194277 | 64225657 |
Upper respiratory tract infection | 85.38 | 10.79 | 238 | 78560 | 72547 | 64347387 |
Hyperhidrosis | 82.79 | 10.79 | 337 | 78461 | 124583 | 64295351 |
Thrombocytopenia | 82.52 | 10.79 | 91 | 78707 | 223710 | 64196224 |
Acute kidney injury | 80.18 | 10.79 | 281 | 78517 | 448959 | 63970975 |
Hyponatraemia | 79.42 | 10.79 | 41 | 78757 | 148298 | 64271636 |
Decorticate posture | 75.43 | 10.79 | 24 | 78774 | 293 | 64419641 |
Neutropenia | 75.29 | 10.79 | 110 | 78688 | 239514 | 64180420 |
Anaemia | 70.85 | 10.79 | 232 | 78566 | 378448 | 64041486 |
Asthma | 68.81 | 10.79 | 264 | 78534 | 94961 | 64324973 |
Headache | 67.71 | 10.79 | 963 | 77835 | 528504 | 63891430 |
Pyrexia | 67.16 | 10.79 | 404 | 78394 | 558240 | 63861694 |
Fibromyalgia | 66.87 | 10.79 | 140 | 78658 | 35591 | 64384343 |
Febrile neutropenia | 66.24 | 10.79 | 79 | 78719 | 187578 | 64232356 |
General physical health deterioration | 66.03 | 10.79 | 92 | 78706 | 204333 | 64215601 |
Cardiac failure | 65.94 | 10.79 | 40 | 78758 | 132333 | 64287601 |
Rash erythematous | 63.02 | 10.79 | 165 | 78633 | 48468 | 64371466 |
Leukopenia | 60.40 | 10.79 | 24 | 78774 | 101218 | 64318716 |
Synovitis | 59.92 | 10.79 | 23 | 78775 | 99067 | 64320867 |
Spinal operation | 56.25 | 10.79 | 52 | 78746 | 6081 | 64413853 |
Suspected suicide | 53.03 | 10.79 | 59 | 78739 | 8595 | 64411339 |
Hand deformity | 52.96 | 10.79 | 7 | 78791 | 62764 | 64357170 |
Drug interaction | 52.25 | 10.79 | 246 | 78552 | 361837 | 64058097 |
Anxiety | 51.35 | 10.79 | 423 | 78375 | 202226 | 64217708 |
C-reactive protein increased | 51.13 | 10.79 | 26 | 78772 | 94883 | 64325051 |
Pericarditis | 50.36 | 10.79 | 8 | 78790 | 62508 | 64357426 |
Renal impairment | 49.62 | 10.79 | 55 | 78743 | 134962 | 64284972 |
Memory impairment | 48.91 | 10.79 | 221 | 78577 | 85461 | 64334473 |
Blood creatinine increased | 48.07 | 10.79 | 57 | 78741 | 135725 | 64284209 |
Pancytopenia | 47.77 | 10.79 | 63 | 78735 | 143246 | 64276688 |
Exposure via ingestion | 47.76 | 10.79 | 43 | 78755 | 4859 | 64415075 |
Pulmonary malformation | 47.07 | 10.79 | 14 | 78784 | 134 | 64419800 |
Interstitial lung disease | 46.65 | 10.79 | 31 | 78767 | 97701 | 64322233 |
Lower respiratory tract infection | 46.54 | 10.79 | 29 | 78769 | 94585 | 64325349 |
Psoriasis | 46.34 | 10.79 | 192 | 78606 | 71511 | 64348423 |
Back disorder | 46.19 | 10.79 | 59 | 78739 | 9931 | 64410003 |
Rheumatoid arthritis | 46.03 | 10.79 | 351 | 78447 | 163943 | 64255991 |
Malignant neoplasm progression | 46.02 | 10.79 | 42 | 78756 | 112829 | 64307105 |
Hyperkalaemia | 45.73 | 10.79 | 34 | 78764 | 101095 | 64318839 |
Maternal exposure during pregnancy | 44.98 | 10.79 | 31 | 78767 | 95853 | 64324081 |
Multiple organ dysfunction syndrome | 44.70 | 10.79 | 35 | 78763 | 101378 | 64318556 |
Hepatocellular injury | 43.54 | 10.79 | 3 | 78795 | 45232 | 64374702 |
Myocardial depression | 43.41 | 10.79 | 18 | 78780 | 485 | 64419449 |
Off label use | 42.63 | 10.79 | 532 | 78266 | 632274 | 63787660 |
Death | 42.06 | 10.79 | 825 | 77973 | 481880 | 63938054 |
Post-traumatic neck syndrome | 41.55 | 10.79 | 27 | 78771 | 1875 | 64418059 |
Hepatic function abnormal | 40.45 | 10.79 | 14 | 78784 | 64299 | 64355635 |
Gamma-glutamyltransferase increased | 39.54 | 10.79 | 6 | 78792 | 48504 | 64371430 |
Alanine aminotransferase increased | 38.76 | 10.79 | 69 | 78729 | 138962 | 64280972 |
Respiratory depression | 38.33 | 10.79 | 87 | 78711 | 23356 | 64396578 |
Systemic lupus erythematosus | 37.88 | 10.79 | 24 | 78774 | 77588 | 64342346 |
Neck pain | 36.84 | 10.79 | 161 | 78637 | 61372 | 64358562 |
Bone marrow failure | 36.73 | 10.79 | 7 | 78791 | 47945 | 64371989 |
International normalised ratio increased | 36.59 | 10.79 | 26 | 78772 | 79141 | 64340793 |
Hypoglycaemia | 35.99 | 10.79 | 34 | 78764 | 89858 | 64330076 |
Glossodynia | 35.94 | 10.79 | 17 | 78781 | 64679 | 64355255 |
Unresponsive to stimuli | 35.80 | 10.79 | 139 | 78659 | 50254 | 64369680 |
Blepharospasm | 35.67 | 10.79 | 31 | 78767 | 3344 | 64416590 |
Electrocardiogram QT prolonged | 35.55 | 10.79 | 27 | 78771 | 79421 | 64340513 |
Ascites | 34.89 | 10.79 | 16 | 78782 | 61985 | 64357949 |
Melaena | 34.83 | 10.79 | 11 | 78787 | 53537 | 64366397 |
Therapy cessation | 33.99 | 10.79 | 102 | 78696 | 32387 | 64387547 |
Platelet count decreased | 33.95 | 10.79 | 99 | 78699 | 167612 | 64252322 |
Milk-alkali syndrome | 33.84 | 10.79 | 20 | 78778 | 1173 | 64418761 |
Soft tissue injury | 33.48 | 10.79 | 22 | 78776 | 1557 | 64418377 |
Lung cyst | 33.07 | 10.79 | 11 | 78787 | 156 | 64419778 |
Overdose | 32.65 | 10.79 | 318 | 78480 | 159248 | 64260686 |
Decreased appetite | 32.35 | 10.79 | 206 | 78592 | 281083 | 64138851 |
Concussion | 32.25 | 10.79 | 44 | 78754 | 7894 | 64412040 |
Hypoaesthesia | 31.86 | 10.79 | 284 | 78514 | 138824 | 64281110 |
Hostility | 31.17 | 10.79 | 24 | 78774 | 2183 | 64417751 |
Libido increased | 30.98 | 10.79 | 22 | 78776 | 1768 | 64418166 |
Pleural effusion | 30.81 | 10.79 | 68 | 78730 | 126491 | 64293443 |
Sternal fracture | 30.79 | 10.79 | 24 | 78774 | 2223 | 64417711 |
Taste disorder | 30.60 | 10.79 | 47 | 78751 | 9386 | 64410548 |
Hyperaesthesia | 29.86 | 10.79 | 48 | 78750 | 9966 | 64409968 |
Sepsis | 29.49 | 10.79 | 163 | 78635 | 230178 | 64189756 |
Surgery | 28.97 | 10.79 | 88 | 78710 | 28125 | 64391809 |
Drug-induced liver injury | 28.89 | 10.79 | 11 | 78787 | 47632 | 64372302 |
Lactic acidosis | 28.60 | 10.79 | 20 | 78778 | 61390 | 64358544 |
Depression | 28.57 | 10.79 | 346 | 78452 | 182945 | 64236989 |
Back injury | 28.54 | 10.79 | 41 | 78757 | 7716 | 64412218 |
Mucosal inflammation | 28.34 | 10.79 | 21 | 78777 | 62563 | 64357371 |
Injury | 27.99 | 10.79 | 139 | 78659 | 55853 | 64364081 |
Aspartate aminotransferase increased | 27.83 | 10.79 | 66 | 78732 | 119722 | 64300212 |
Cholestasis | 27.82 | 10.79 | 10 | 78788 | 44862 | 64375072 |
Lactation disorder | 27.81 | 10.79 | 10 | 78788 | 181 | 64419753 |
Intervertebral disc protrusion | 27.69 | 10.79 | 70 | 78728 | 20121 | 64399813 |
Serotonin syndrome | 27.62 | 10.79 | 108 | 78690 | 39174 | 64380760 |
Fatigue | 27.39 | 10.79 | 1146 | 77652 | 747584 | 63672350 |
Gastrointestinal disorder | 27.34 | 10.79 | 42 | 78756 | 89667 | 64330267 |
Hypotension | 27.26 | 10.79 | 633 | 78165 | 380341 | 64039593 |
Blood lactate dehydrogenase increased | 27.17 | 10.79 | 4 | 78794 | 33074 | 64386860 |
Atrial fibrillation | 26.58 | 10.79 | 113 | 78685 | 170976 | 64248958 |
Road traffic accident | 26.22 | 10.79 | 90 | 78708 | 30655 | 64389279 |
Drug eruption | 26.18 | 10.79 | 6 | 78792 | 36130 | 64383804 |
Exposure during pregnancy | 26.02 | 10.79 | 34 | 78764 | 77641 | 64342293 |
Meniscus injury | 25.92 | 10.79 | 34 | 78764 | 5873 | 64414061 |
Electrocardiogram QRS complex prolonged | 25.79 | 10.79 | 43 | 78755 | 9201 | 64410733 |
Bronchitis | 25.40 | 10.79 | 223 | 78575 | 108520 | 64311414 |
Cytomegalovirus infection | 25.36 | 10.79 | 7 | 78791 | 37192 | 64382742 |
Gluten sensitivity | 25.12 | 10.79 | 11 | 78787 | 340 | 64419594 |
Drug resistance | 25.09 | 10.79 | 6 | 78792 | 35096 | 64384838 |
Jaundice | 25.08 | 10.79 | 14 | 78784 | 48498 | 64371436 |
Muscle spasms | 25.02 | 10.79 | 273 | 78525 | 140750 | 64279184 |
Uterine perforation | 24.77 | 10.79 | 33 | 78765 | 5787 | 64414147 |
Fracture pain | 24.74 | 10.79 | 11 | 78787 | 353 | 64419581 |
Hypokalaemia | 24.64 | 10.79 | 72 | 78726 | 121831 | 64298103 |
Cardiogenic shock | 24.28 | 10.79 | 5 | 78793 | 32422 | 64387512 |
Disseminated intravascular coagulation | 24.19 | 10.79 | 5 | 78793 | 32343 | 64387591 |
Blood alkaline phosphatase increased | 24.07 | 10.79 | 20 | 78778 | 56259 | 64363675 |
Therapy interrupted | 23.95 | 10.79 | 66 | 78732 | 19970 | 64399964 |
Rash maculo-papular | 23.70 | 10.79 | 14 | 78784 | 47012 | 64372922 |
Emotional distress | 23.67 | 10.79 | 97 | 78701 | 35941 | 64383993 |
Circulatory collapse | 23.66 | 10.79 | 6 | 78792 | 33726 | 64386208 |
Pneumocystis jirovecii pneumonia | 23.50 | 10.79 | 3 | 78795 | 27631 | 64392303 |
Vascular malformation | 23.37 | 10.79 | 10 | 78788 | 292 | 64419642 |
Intervertebral disc degeneration | 22.92 | 10.79 | 50 | 78748 | 13070 | 64406864 |
Agranulocytosis | 22.89 | 10.79 | 9 | 78789 | 38220 | 64381714 |
Blood bilirubin increased | 22.77 | 10.79 | 22 | 78776 | 57531 | 64362403 |
Tubulointerstitial nephritis | 22.66 | 10.79 | 5 | 78793 | 30904 | 64389030 |
Altered state of consciousness | 22.57 | 10.79 | 9 | 78789 | 37893 | 64382041 |
Respiratory failure | 22.33 | 10.79 | 111 | 78687 | 161072 | 64258862 |
Maternal exposure during breast feeding | 22.28 | 10.79 | 19 | 78779 | 1997 | 64417937 |
Paranasal cyst | 22.12 | 10.79 | 10 | 78788 | 334 | 64419600 |
Personality disorder | 22.06 | 10.79 | 28 | 78770 | 4683 | 64415251 |
Feeling abnormal | 22.05 | 10.79 | 255 | 78543 | 133347 | 64286587 |
Lower limb fracture | 21.84 | 10.79 | 50 | 78748 | 13495 | 64406439 |
Pre-existing condition improved | 21.82 | 10.79 | 28 | 78770 | 4734 | 64415200 |
Gastrooesophageal reflux disease | 21.81 | 10.79 | 175 | 78623 | 82968 | 64336966 |
Dyspnoea | 21.73 | 10.79 | 691 | 78107 | 717983 | 63701951 |
Hypocalcaemia | 21.65 | 10.79 | 12 | 78786 | 41741 | 64378193 |
Syncope | 21.02 | 10.79 | 110 | 78688 | 157525 | 64262409 |
Hepatic failure | 20.97 | 10.79 | 22 | 78776 | 55372 | 64364562 |
Oedema peripheral | 20.74 | 10.79 | 161 | 78637 | 210156 | 64209778 |
Painful ejaculation | 20.60 | 10.79 | 4 | 78794 | 3 | 64419931 |
Erythema | 20.58 | 10.79 | 332 | 78466 | 186738 | 64233196 |
Serum sickness-like reaction | 20.42 | 10.79 | 11 | 78787 | 539 | 64419395 |
Wound | 20.38 | 10.79 | 39 | 78759 | 76438 | 64343496 |
Withdrawal syndrome | 20.24 | 10.79 | 69 | 78729 | 23423 | 64396511 |
Dry mouth | 19.74 | 10.79 | 134 | 78664 | 60284 | 64359650 |
Stress | 19.63 | 10.79 | 134 | 78664 | 60400 | 64359534 |
Rhinorrhoea | 19.59 | 10.79 | 133 | 78665 | 59836 | 64360098 |
Multiple sclerosis | 19.37 | 10.79 | 59 | 78739 | 18882 | 64401052 |
Neutrophil count decreased | 19.18 | 10.79 | 41 | 78757 | 77155 | 64342779 |
Exposure via breast milk | 19.16 | 10.79 | 12 | 78786 | 782 | 64419152 |
Application site burn | 19.13 | 10.79 | 12 | 78786 | 784 | 64419150 |
Bradycardia | 19.03 | 10.79 | 77 | 78721 | 118142 | 64301792 |
Dysphoria | 18.86 | 10.79 | 25 | 78773 | 4363 | 64415571 |
Pneumonia aspiration | 18.79 | 10.79 | 27 | 78771 | 59244 | 64360690 |
Prescribed overdose | 18.65 | 10.79 | 61 | 78737 | 20270 | 64399664 |
Infusion related reaction | 18.60 | 10.79 | 121 | 78677 | 164346 | 64255588 |
Infection | 18.48 | 10.79 | 141 | 78657 | 184739 | 64235195 |
Haemoglobin decreased | 18.46 | 10.79 | 151 | 78647 | 194912 | 64225022 |
Poor quality sleep | 18.42 | 10.79 | 58 | 78740 | 18893 | 64401041 |
Septic shock | 18.04 | 10.79 | 67 | 78731 | 105370 | 64314564 |
Liver function test abnormal | 17.92 | 10.79 | 28 | 78770 | 59373 | 64360561 |
Respiratory tract malformation | 17.72 | 10.79 | 5 | 78793 | 39 | 64419895 |
Acute hepatic failure | 17.64 | 10.79 | 5 | 78793 | 26107 | 64393827 |
Haematemesis | 17.42 | 10.79 | 19 | 78779 | 46980 | 64372954 |
Lymphatic system neoplasm | 17.29 | 10.79 | 5 | 78793 | 43 | 64419891 |
Lymphopenia | 17.17 | 10.79 | 5 | 78793 | 25652 | 64394282 |
Neurotoxicity | 17.17 | 10.79 | 6 | 78792 | 27398 | 64392536 |
Cerebral infarction | 17.05 | 10.79 | 15 | 78783 | 41029 | 64378905 |
Cardiac failure congestive | 16.92 | 10.79 | 92 | 78706 | 130488 | 64289446 |
Insomnia | 16.77 | 10.79 | 337 | 78461 | 197499 | 64222435 |
Gastrointestinal haemorrhage | 16.72 | 10.79 | 94 | 78704 | 132218 | 64287716 |
Stomatitis | 16.64 | 10.79 | 73 | 78725 | 109532 | 64310402 |
Transaminases increased | 16.55 | 10.79 | 18 | 78780 | 44576 | 64375358 |
Paraesthesia | 16.42 | 10.79 | 243 | 78555 | 134279 | 64285655 |
Muscle injury | 16.20 | 10.79 | 6 | 78792 | 26431 | 64393503 |
Stevens-Johnson syndrome | 16.15 | 10.79 | 11 | 78787 | 34238 | 64385696 |
Renal failure | 16.13 | 10.79 | 143 | 78655 | 181545 | 64238389 |
Hepatotoxicity | 16.13 | 10.79 | 15 | 78783 | 39947 | 64379987 |
Allodynia | 16.07 | 10.79 | 13 | 78785 | 1270 | 64418664 |
Proteinuria | 15.84 | 10.79 | 7 | 78791 | 27716 | 64392218 |
Cholecystitis chronic | 15.78 | 10.79 | 35 | 78763 | 9252 | 64410682 |
Upper gastrointestinal haemorrhage | 15.71 | 10.79 | 12 | 78786 | 35208 | 64384726 |
Muscle twitching | 15.67 | 10.79 | 55 | 78743 | 18943 | 64400991 |
Cerebral haemorrhage | 15.49 | 10.79 | 24 | 78774 | 51066 | 64368868 |
Urinary incontinence | 15.49 | 10.79 | 86 | 78712 | 36065 | 64383869 |
Blood creatine phosphokinase increased | 15.48 | 10.79 | 30 | 78768 | 58528 | 64361406 |
Pneumonia | 15.47 | 10.79 | 544 | 78254 | 559032 | 63860902 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 15.38 | 10.79 | 12 | 78786 | 1113 | 64418821 |
Liver disorder | 15.29 | 10.79 | 26 | 78772 | 53325 | 64366609 |
Disease progression | 15.14 | 10.79 | 106 | 78692 | 141574 | 64278360 |
Ankylosing spondylitis | 15.09 | 10.79 | 32 | 78766 | 8202 | 64411732 |
Polyneuropathy | 15.03 | 10.79 | 3 | 78795 | 19891 | 64400043 |
Nightmare | 14.98 | 10.79 | 58 | 78740 | 20935 | 64398999 |
Osteonecrosis of jaw | 14.87 | 10.79 | 16 | 78782 | 39809 | 64380125 |
Hyperglycaemia | 14.63 | 10.79 | 33 | 78765 | 60935 | 64358999 |
Rotator cuff syndrome | 14.59 | 10.79 | 40 | 78758 | 12067 | 64407867 |
Therapeutic product effect decreased | 14.54 | 10.79 | 82 | 78716 | 115269 | 64304665 |
Sciatica | 14.47 | 10.79 | 56 | 78742 | 20208 | 64399726 |
Myelodysplastic syndrome | 14.20 | 10.79 | 8 | 78790 | 27571 | 64392363 |
Bronchopulmonary aspergillosis | 14.17 | 10.79 | 3 | 78795 | 19082 | 64400852 |
Psoriatic arthropathy | 14.14 | 10.79 | 96 | 78702 | 43185 | 64376749 |
Ischaemic stroke | 14.13 | 10.79 | 9 | 78789 | 29026 | 64390908 |
Muscle strain | 14.05 | 10.79 | 31 | 78767 | 8163 | 64411771 |
Rib fracture | 13.70 | 10.79 | 62 | 78736 | 23976 | 64395958 |
Injection site mass | 13.39 | 10.79 | 49 | 78749 | 17221 | 64402713 |
Peritonitis | 13.26 | 10.79 | 7 | 78791 | 25016 | 64394918 |
Pneumonitis | 13.14 | 10.79 | 26 | 78772 | 50339 | 64369595 |
Irritability | 12.91 | 10.79 | 83 | 78715 | 36663 | 64383271 |
Gait disturbance | 12.89 | 10.79 | 288 | 78510 | 171867 | 64248067 |
Angioedema | 12.86 | 10.79 | 36 | 78762 | 61785 | 64358149 |
Confusional state | 12.86 | 10.79 | 233 | 78565 | 260911 | 64159023 |
Sinusitis | 12.84 | 10.79 | 250 | 78548 | 145678 | 64274256 |
Mastoiditis | 12.77 | 10.79 | 12 | 78786 | 1433 | 64418501 |
Extrapyramidal disorder | 12.74 | 10.79 | 4 | 78794 | 19548 | 64400386 |
Muscle neoplasm | 12.34 | 10.79 | 4 | 78794 | 52 | 64419882 |
Sinus headache | 12.32 | 10.79 | 20 | 78778 | 4187 | 64415747 |
Pulmonary fibrosis | 12.31 | 10.79 | 11 | 78787 | 29867 | 64390067 |
Pain in extremity | 12.19 | 10.79 | 469 | 78329 | 302616 | 64117318 |
Rash | 12.15 | 10.79 | 448 | 78350 | 458101 | 63961833 |
Anuria | 12.15 | 10.79 | 4 | 78794 | 18960 | 64400974 |
Pelvic pain | 12.12 | 10.79 | 35 | 78763 | 10875 | 64409059 |
Myocarditis | 12.01 | 10.79 | 3 | 78795 | 17040 | 64402894 |
Intentional overdose | 11.98 | 10.79 | 165 | 78633 | 89779 | 64330155 |
Injection site pain | 11.97 | 10.79 | 197 | 78601 | 111211 | 64308723 |
Drug ineffective | 11.93 | 10.79 | 875 | 77923 | 839372 | 63580562 |
Therapy non-responder | 11.85 | 10.79 | 41 | 78757 | 65858 | 64354076 |
Oropharyngeal pain | 11.83 | 10.79 | 163 | 78635 | 88704 | 64331230 |
Poor sucking reflex | 11.76 | 10.79 | 4 | 78794 | 61 | 64419873 |
Thrombosis | 11.72 | 10.79 | 135 | 78663 | 70507 | 64349427 |
Appetite disorder | 11.72 | 10.79 | 25 | 78773 | 6436 | 64413498 |
Treatment failure | 11.71 | 10.79 | 89 | 78709 | 116727 | 64303207 |
Major depression | 11.67 | 10.79 | 28 | 78770 | 7788 | 64412146 |
Hypophagia | 11.62 | 10.79 | 19 | 78779 | 39568 | 64380366 |
Myocardial ischaemia | 11.60 | 10.79 | 7 | 78791 | 23244 | 64396690 |
Throat irritation | 11.56 | 10.79 | 74 | 78724 | 32637 | 64387297 |
Lung disorder | 11.44 | 10.79 | 37 | 78761 | 60663 | 64359271 |
Blood urea increased | 11.34 | 10.79 | 23 | 78775 | 44130 | 64375804 |
Catheter site bruise | 11.25 | 10.79 | 6 | 78792 | 288 | 64419646 |
Foot fracture | 11.24 | 10.79 | 48 | 78750 | 18109 | 64401825 |
Gallbladder neoplasm | 11.09 | 10.79 | 4 | 78794 | 73 | 64419861 |
Suicidal ideation | 10.96 | 10.79 | 127 | 78671 | 66415 | 64353519 |
Total lung capacity | 10.91 | 10.79 | 3 | 78795 | 21 | 64419913 |
Hypoalbuminaemia | 10.85 | 10.79 | 4 | 78794 | 17670 | 64402264 |
Basal cell carcinoma | 10.85 | 10.79 | 13 | 78785 | 30825 | 64389109 |
None
Source | Code | Description |
---|---|---|
ATC | M03BX08 | MUSCULO-SKELETAL SYSTEM MUSCLE RELAXANTS MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS Other centrally acting agents |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D000929 | Antidepressive Agents, Tricyclic |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D009125 | Muscle Relaxants, Central |
MeSH PA | D009465 | Neuromuscular Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D014149 | Tranquilizing Agents |
CHEBI has role | CHEBI:35469 | antidepressants |
CHEBI has role | CHEBI:35473 | tranquilizing drugs |
CHEBI has role | CHEBI:51371 | muscle relaxants |
FDA PE | N0000175730 | Centrally-mediated Muscle Relaxation |
FDA EPC | N0000175737 | Muscle Relaxant |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Spasticity | indication | 221360009 | |
Fibromyalgia | off-label use | 203082005 | DOID:631 |
Sinus tachycardia | contraindication | 11092001 | |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Conduction disorder of the heart | contraindication | 44808001 | |
Chronic heart failure | contraindication | 48447003 | |
Hepatic failure | contraindication | 59927004 | |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Heart block | contraindication | 233916004 | |
Retention of urine | contraindication | 267064002 | |
Myocardial infarction in recovery phase | contraindication | 418044006 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.66 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
15MG | AMRIX | TEVA PHARMS INTL | N021777 | Feb. 1, 2007 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 7544372 | Nov. 14, 2023 | RELIEF OF MUSCLE SPASM |
15MG | AMRIX | TEVA PHARMS INTL | N021777 | Feb. 1, 2007 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 7829121 | Nov. 14, 2023 | RELIEF OF MUSCLE SPASM |
15MG | AMRIX | TEVA PHARMS INTL | N021777 | Feb. 1, 2007 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8877245 | Nov. 14, 2023 | RELIEF OF MUSCLE SPASM |
15MG | AMRIX | TEVA PHARMS INTL | N021777 | Feb. 1, 2007 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9375410 | Nov. 14, 2023 | RELIEF OF MUSCLE SPASM |
15MG | AMRIX | TEVA PHARMS INTL | N021777 | Feb. 1, 2007 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9399025 | Nov. 14, 2023 | RELIEF OF MUSCLE SPASM |
30MG | AMRIX | TEVA PHARMS INTL | N021777 | Feb. 1, 2007 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 7544372 | Nov. 14, 2023 | RELIEF OF MUSCLE SPASM |
30MG | AMRIX | TEVA PHARMS INTL | N021777 | Feb. 1, 2007 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 7829121 | Nov. 14, 2023 | RELIEF OF MUSCLE SPASM |
30MG | AMRIX | TEVA PHARMS INTL | N021777 | Feb. 1, 2007 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8877245 | Nov. 14, 2023 | RELIEF OF MUSCLE SPASM |
30MG | AMRIX | TEVA PHARMS INTL | N021777 | Feb. 1, 2007 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9375410 | Nov. 14, 2023 | RELIEF OF MUSCLE SPASM |
30MG | AMRIX | TEVA PHARMS INTL | N021777 | Feb. 1, 2007 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9399025 | Nov. 14, 2023 | RELIEF OF MUSCLE SPASM |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 2A | GPCR | ANTAGONIST | Ki | 7.54 | WOMBAT-PK | CHEMBL | |||
Sodium-dependent serotonin transporter | Transporter | Ki | 6.97 | WOMBAT-PK | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 7.44 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 6.81 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2C | GPCR | ANTAGONIST | Ki | 7.24 | WOMBAT-PK | ||||
5-hydroxytryptamine receptor 6 | GPCR | Ki | 6.84 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 7 | GPCR | Ki | 6.82 | WOMBAT-PK | |||||
Histamine H1 receptor | GPCR | Ki | 8.83 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M1 | GPCR | IC50 | 6.95 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M2 | GPCR | Ki | 7.22 | PDSP | |||||
Muscarinic acetylcholine receptor M3 | GPCR | Ki | 8.22 | PDSP | |||||
Aldehyde oxidase | Enzyme | IC50 | 5.51 | WOMBAT-PK | |||||
Multidrug resistance protein 1 | Transporter | IC50 | 4.73 | WOMBAT-PK | |||||
Proto-oncogene tyrosine-protein kinase receptor Ret | Kinase | IC50 | 6.52 | CHEMBL |
ID | Source |
---|---|
4019699 | VUID |
N0000147791 | NUI |
D00772 | KEGG_DRUG |
6202-23-9 | SECONDARY_CAS_RN |
21949 | RXNORM |
4017956 | VANDF |
4019699 | VANDF |
C0056732 | UMLSCUI |
CHEBI:3996 | CHEBI |
CHEMBL669 | ChEMBL_ID |
DB00924 | DRUGBANK_ID |
CHEMBL1200636 | ChEMBL_ID |
C004704 | MESH_SUPPLEMENTAL_RECORD_UI |
2895 | PUBCHEM_CID |
7152 | IUPHAR_LIGAND_ID |
791 | INN_ID |
69O5WQQ5TI | UNII |
217 | MMSL |
4517 | MMSL |
d00963 | MMSL |
001678 | NDDF |
004680 | NDDF |
373779004 | SNOMEDCT_US |
63083007 | SNOMEDCT_US |
80802008 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-1920 | CAPSULE, EXTENDED RELEASE | 15 mg | ORAL | NDA authorized generic | 30 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-1921 | CAPSULE, EXTENDED RELEASE | 30 mg | ORAL | NDA authorized generic | 30 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3420 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 20 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3421 | TABLET, FILM COATED | 7.50 mg | ORAL | ANDA | 20 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3422 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 20 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1436 | CAPSULE, EXTENDED RELEASE | 15 mg | ORAL | NDA AUTHORIZED GENERIC | 28 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1437 | CAPSULE, EXTENDED RELEASE | 30 mg | ORAL | NDA AUTHORIZED GENERIC | 28 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-1350 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 20 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-7350 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 19 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3256 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 20 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3330 | TABLET, FILM COATED | 7.50 mg | ORAL | ANDA | 20 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-5658 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 20 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8084 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 21 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8182 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 14 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7809 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 20 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-072 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 23 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-159 | TABLET | 10 mg | ORAL | ANDA | 13 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-200 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 13 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10702-006 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 13 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10702-007 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 13 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-528 | TABLET | 10 mg | ORAL | ANDA | 20 sections |
Cyclobenzaprine Hydrochloride | Human Prescription Drug Label | 1 | 16571-782 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 23 sections |
Cyclobenzaprine Hydrochloride | Human Prescription Drug Label | 1 | 16571-783 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 23 sections |
CYCLOBENZAPRINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-065 | TABLET | 10 mg | ORAL | ANDA | 12 sections |
CYCLOBENZAPRINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-544 | TABLET | 5 mg | ORAL | ANDA | 12 sections |
Amrix | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-596 | CAPSULE, EXTENDED RELEASE | 15 mg | ORAL | NDA | 13 sections |
FEXMID | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-699 | TABLET, FILM COATED | 7.50 mg | ORAL | ANDA | 22 sections |
Amrix | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-810 | CAPSULE, EXTENDED RELEASE | 30 mg | ORAL | NDA | 13 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-036 | TABLET | 5 mg | ORAL | ANDA | 13 sections |
Cyclobenzaprine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-037 | TABLET | 10 mg | ORAL | ANDA | 13 sections |