cyamemazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
746 3546-03-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cyamemazine
  • ciamatil
  • cianatil
  • cyamemazin
  • cyamepromazine
  • cyamepromezine
phototoxic neuroleptic effects
  • Molecular weight: 323.46
  • Formula: C19H21N3S
  • CLOGP: 4.87
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 30.27
  • ALOGS: -4.05
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Coma 946.61 51.41 315 5043 56564 50543202
Poisoning deliberate 553.65 51.41 135 5223 7777 50591989
Toxicity to various agents 253.62 51.41 196 5162 212303 50387463
Somnolence 236.67 51.41 166 5192 154819 50444947
Hepatocellular injury 182.92 51.41 77 5281 25870 50573896
Rhabdomyolysis 164.72 51.41 81 5277 38946 50560820
Suicide attempt 156.91 51.41 86 5272 51646 50548120
Altered state of consciousness 141.08 51.41 61 5297 21849 50577917
Drug abuse 127.16 51.41 79 5279 59767 50539999
Hypotension 126.01 51.41 139 5219 235330 50364436
Intentional overdose 121.52 51.41 78 5280 62426 50537340
Extrapyramidal disorder 121.43 51.41 46 5312 11724 50588042
Miosis 112.32 51.41 37 5321 6273 50593493
Bladder dilatation 95.49 51.41 21 5337 757 50599009
Urinary retention 86.15 51.41 46 5312 26144 50573622
Asphyxia 81.46 51.41 28 5330 5399 50594367
Hypotonia neonatal 74.64 51.41 18 5340 979 50598787
Tachycardia 73.28 51.41 70 5288 99693 50500073
Neuroleptic malignant syndrome 68.37 51.41 30 5328 11100 50588666
Serotonin syndrome 61.10 51.41 36 5322 24677 50575089
Wrong patient received product 60.52 51.41 17 5341 1683 50598083
Megacolon 60.46 51.41 17 5341 1689 50598077
Poisoning 59.00 51.41 28 5330 12401 50587365
Cerebral microhaemorrhage 58.93 51.41 10 5348 86 50599680
Vasoplegia syndrome 57.82 51.41 15 5343 1099 50598667
Faecal vomiting 56.76 51.41 13 5345 564 50599202
Brain death 52.26 51.41 17 5341 2766 50597000
Pyramidal tract syndrome 51.67 51.41 11 5347 339 50599427

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Coma 994.36 40.97 337 4787 39113 29530290
Poisoning deliberate 477.08 40.97 124 5000 5607 29563796
Miosis 304.51 40.97 94 5030 7915 29561488
Drug abuse 287.99 40.97 176 4948 79707 29489696
Somnolence 223.97 40.97 160 4964 93795 29475608
Asphyxia 183.53 40.97 58 5066 5257 29564146
Altered state of consciousness 106.66 40.97 57 5067 19832 29549571
Intentional overdose 103.95 40.97 71 5053 38457 29530946
Extrapyramidal disorder 103.23 40.97 46 5078 10785 29558618
Hepatocellular injury 103.14 40.97 57 5067 21186 29548217
Pneumonia aspiration 97.44 40.97 67 5057 36670 29532733
Toxicity to various agents 91.32 40.97 130 4994 173531 29395872
Mydriasis 88.75 40.97 35 5089 6050 29563353
Wrong patient 69.90 40.97 13 5111 115 29569288
Rhabdomyolysis 65.94 40.97 66 5058 60742 29508661
Bladder dilatation 65.41 40.97 19 5105 1289 29568114
Respiratory depression 64.81 40.97 36 5088 13487 29555916
Colitis ischaemic 62.82 40.97 27 5097 5796 29563607
Hyperthermia 61.95 40.97 31 5093 9399 29560004
Depressed level of consciousness 61.44 40.97 51 5073 36891 29532512
Suicide attempt 60.74 40.97 49 5075 34061 29535342
Drug dependence 59.69 40.97 40 5084 20941 29548462
Disturbance in attention 58.94 40.97 40 5084 21384 29548019
Sedation 56.39 40.97 36 5088 17369 29552034
Rheumatoid nodule 44.76 40.97 16 5108 2106 29567297
Bradypnoea 43.03 40.97 16 5108 2355 29567048
Tachycardia 42.02 40.97 57 5067 72353 29497050

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Coma 1839.24 40.20 639 9614 86976 64401503
Poisoning deliberate 983.81 40.20 258 9995 13200 64475279
Somnolence 449.58 40.20 320 9933 203325 64285154
Miosis 412.83 40.20 131 10122 13135 64475344
Drug abuse 384.88 40.20 247 10006 132127 64356352
Toxicity to various agents 292.38 40.20 322 9931 363191 64125288
Hepatocellular injury 263.00 40.20 133 10120 45102 64443377
Altered state of consciousness 239.66 40.20 118 10135 37784 64450695
Asphyxia 238.85 40.20 80 10173 9486 64478993
Intentional overdose 213.07 40.20 148 10105 89796 64398683
Suicide attempt 209.56 40.20 134 10119 70873 64417606
Extrapyramidal disorder 186.50 40.20 81 10172 19471 64469008
Rhabdomyolysis 185.23 40.20 137 10116 91589 64396890
Bladder dilatation 156.80 40.20 40 10213 1814 64486665
Pneumonia aspiration 141.31 40.20 98 10155 59173 64429306
Urinary retention 116.43 40.20 81 10172 49120 64439359
Mydriasis 115.93 40.20 54 10199 15258 64473221
Tachycardia 98.48 40.20 120 10133 149459 64339020
Hypotension 96.85 40.20 197 10056 380777 64107702
Neuroleptic malignant syndrome 91 40.20 54 10199 24942 64463537
Disturbance in attention 86.50 40.20 63 10190 41011 64447468
Depressed level of consciousness 84.41 40.20 83 10170 81353 64407126
Hyperthermia 79.52 40.20 42 10211 15508 64472971
Wrong patient 77.85 40.20 15 10238 179 64488300
Overdose 77.10 40.20 110 10143 159456 64329023
Bradypnoea 71.71 40.20 28 10225 5131 64483348
Respiratory depression 70.91 40.20 45 10208 23398 64465081
Colitis ischaemic 70.78 40.20 37 10216 13377 64475102
Electrocardiogram QT prolonged 69.65 40.20 74 10179 79374 64409105
Pain 68.99 40.20 5 10248 553506 63934973
Poisoning 68.69 40.20 43 10210 21836 64466643
Drug dependence 67.65 40.20 50 10203 33262 64455217
Sedation 66.28 40.20 54 10199 41408 64447071
Fatigue 63.83 40.20 20 10233 748710 63739769
Agitation 63.19 40.20 74 10179 88293 64400186
Pneumonia 59.65 40.20 9 10244 559567 63928912
Nausea 58.59 40.20 26 10227 785774 63702705
Arthralgia 58.06 40.20 3 10250 442257 64046222
Confusional state 58.01 40.20 128 10125 261016 64227463
Drug interaction 57.58 40.20 156 10097 361927 64126552
Dizziness 56.21 40.20 3 10250 430160 64058319
Wrong patient received product 54.35 40.20 21 10232 3741 64484738
Drug use disorder 54.18 40.20 24 10229 6030 64482449
Blood creatine phosphokinase increased 53.90 40.20 56 10197 58502 64429977
Drug reaction with eosinophilia and systemic symptoms 53.81 40.20 54 10199 54163 64434316
Aggression 53.31 40.20 50 10203 46182 64442297
Drug ineffective 52.17 40.20 35 10218 840212 63648267
Chemical submission 51.91 40.20 11 10242 217 64488262
Faecaloma 51.80 40.20 27 10226 9701 64478778
Vasoplegia syndrome 49.27 40.20 18 10235 2749 64485730
Headache 49.05 40.20 12 10241 529455 63959024
Cerebral microhaemorrhage 47.80 40.20 10 10243 185 64488294
Megacolon 47.38 40.20 18 10235 3064 64485415
Cholestasis 46.95 40.20 46 10207 44826 64443653
Hepatic cytolysis 45.07 40.20 28 10225 14021 64474458
Psychomotor skills impaired 43.51 40.20 18 10235 3827 64484652
Serotonin syndrome 42.46 40.20 41 10212 39241 64449238
Subileus 42.20 40.20 19 10234 4958 64483521
Dyspnoea 40.59 40.20 33 10220 718641 63769838

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AA06 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Phenothiazines with aliphatic side-chain

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.92 Basic
pKa2 2.39 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(1A) dopamine receptor GPCR Ki 8.42 PDSP
D(2) dopamine receptor GPCR Ki 8.24 PDSP
5-hydroxytryptamine receptor 1A GPCR ANTAGONIST Ki 6.30 IUPHAR
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 8.80 IUPHAR
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST Ki 7.90 IUPHAR
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 7.20 IUPHAR
D(3) dopamine receptor GPCR Ki 8.60 PDSP
Muscarinic acetylcholine receptor M1 GPCR Ki 7.89 PDSP
Muscarinic acetylcholine receptor M2 GPCR Ki 7.38 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 7.50 PDSP
Muscarinic acetylcholine receptor M4 GPCR Ki 7.92 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 7.46 PDSP
5-hydroxytryptamine receptor 3A Ion channel Ki 5.53 PDSP

External reference:

IDSource
D07307 KEGG_DRUG
21877 RXNORM
C0056643 UMLSCUI
CHEBI:135379 CHEBI
CHEMBL2104153 ChEMBL_ID
DB09000 DRUGBANK_ID
C028457 MESH_SUPPLEMENTAL_RECORD_UI
62865 PUBCHEM_CID
84 IUPHAR_LIGAND_ID
1148 INN_ID
A2JGV5CNU4 UNII
005507 NDDF

Pharmaceutical products:

None