cyamemazine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
746 3546-03-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cyamemazine
  • ciamatil
  • cianatil
  • cyamemazin
  • cyamepromazine
  • cyamepromezine
phototoxic neuroleptic effects
  • Molecular weight: 323.46
  • Formula: C19H21N3S
  • CLOGP: 4.87
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 30.27
  • ALOGS: -4.05
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 223.79 139.08 54 139 32700 2325192

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Coma 202.40 150.62 43 183 7219 1739336

Pharmacologic Action:

SourceCodeDescription
ATC N05AA06 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Phenothiazines with aliphatic side-chain

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.92 Basic
pKa2 2.39 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 3A Ion channel Ki 5.53 PDSP
D(3) dopamine receptor GPCR Ki 8.60 PDSP
D(1A) dopamine receptor GPCR Ki 8.42 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 7.49 PDSP
D(2) dopamine receptor GPCR Ki 8.24 PDSP
Muscarinic acetylcholine receptor M1 GPCR Ki 7.89 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 7.46 PDSP
Muscarinic acetylcholine receptor M4 GPCR Ki 7.92 PDSP
Muscarinic acetylcholine receptor M2 GPCR Ki 7.38 PDSP
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 8.80 IUPHAR
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST Ki 7.90 IUPHAR
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 7.20 IUPHAR
5-hydroxytryptamine receptor 1A GPCR ANTAGONIST Ki 6.30 IUPHAR

External reference:

IDSource
C0056643 UMLSCUI
D07307 KEGG_DRUG
21877 RXNORM
005507 NDDF
A2JGV5CNU4 UNII
1148 INN_ID
C028457 MESH_SUPPLEMENTAL_RECORD_UI
DB09000 DRUGBANK_ID
CHEBI:135379 CHEBI
84 IUPHAR_LIGAND_ID
62865 PUBCHEM_CID
CHEMBL2104153 ChEMBL_ID

Pharmaceutical products:

None