cyamemazine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
746 3546-03-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cyamemazine
  • ciamatil
  • cianatil
  • cyamemazin
  • cyamepromazine
  • cyamepromezine
phototoxic neuroleptic effects
  • Molecular weight: 323.46
  • Formula: C19H21N3S
  • CLOGP: 4.87
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 30.27
  • ALOGS: -4.05
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Coma 910.95 48.20 309 5093 61474 53282190
Poisoning deliberate 633.69 48.20 152 5250 8561 53335103
Toxicity to various agents 314.81 48.20 222 5180 219376 53124288
Somnolence 180.14 48.20 143 5259 167591 53176073
Hepatocellular injury 159.43 48.20 72 5330 29914 53313750
Suicide attempt 156.48 48.20 88 5314 58080 53285584
Rhabdomyolysis 156.15 48.20 80 5322 43843 53299821
Intentional overdose 139.54 48.20 86 5316 67119 53276545
Altered state of consciousness 136.34 48.20 61 5341 24775 53318889
Extrapyramidal disorder 124.70 48.20 47 5355 12355 53331309
Hypotension 122.41 48.20 139 5263 253937 53089727
Miosis 110.16 48.20 37 5365 6965 53336699
Drug abuse 97.23 48.20 68 5334 65458 53278206
Bladder dilatation 95.55 48.20 21 5381 790 53342874
Wrong patient received product 94.12 48.20 25 5377 2103 53341561
Urinary retention 84.48 48.20 46 5356 28420 53315244
Hypotonia neonatal 74.12 48.20 18 5384 1055 53342609
Neuroleptic malignant syndrome 70.63 48.20 31 5371 12002 53331662
Asphyxia 69.00 48.20 25 5377 5876 53337788
Tachycardia 67.39 48.20 68 5334 108144 53235520
Megacolon 58.83 48.20 17 5385 1949 53341715
Poisoning 57.30 48.20 28 5374 13822 53329842
Vasoplegia syndrome 56.75 48.20 15 5387 1237 53342427
Cerebral microhaemorrhage 56.28 48.20 10 5392 121 53343543
Overdose 55.14 48.20 61 5341 107675 53235989
Drug interaction 53.02 48.20 86 5316 219243 53124421
Pyramidal tract syndrome 51.82 48.20 11 5391 350 53343314
Brain death 51.71 48.20 17 5385 2991 53340673
Faecal vomiting 50.22 48.20 12 5390 656 53343008

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Coma 970.30 38.87 333 5008 42279 32465906
Poisoning deliberate 548.24 38.87 140 5201 6235 32501950
Miosis 301.70 38.87 94 5247 8610 32499575
Drug abuse 269.90 38.87 166 5175 80077 32428108
Somnolence 212.71 38.87 158 5183 103639 32404546
Asphyxia 183.57 38.87 58 5283 5542 32502643
Intentional overdose 136.68 38.87 85 5256 41516 32466669
Toxicity to various agents 135.93 38.87 156 5185 177885 32330300
Extrapyramidal disorder 104.62 38.87 47 5294 11848 32496337
Altered state of consciousness 104.11 38.87 57 5284 21940 32486245
Wrong patient 103.32 38.87 18 5323 112 32508073
Hepatocellular injury 101.93 38.87 59 5282 25259 32482926
Pneumonia aspiration 96.08 38.87 68 5273 41088 32467097
Rhabdomyolysis 78.15 38.87 74 5267 67191 32440994
Mydriasis 64.83 38.87 28 5313 6418 32501767
Respiratory depression 64.59 38.87 35 5306 13176 32495009
Suicide attempt 64.38 38.87 52 5289 38192 32469993
Bladder dilatation 64.19 38.87 19 5322 1453 32506732
Hyperthermia 62.62 38.87 32 5309 10696 32497489
Colitis ischaemic 62.08 38.87 27 5314 6293 32501892
Depressed level of consciousness 59.33 38.87 51 5290 40796 32467389
Drug dependence 57.53 38.87 40 5301 23444 32484741
Disturbance in attention 57.12 38.87 40 5301 23713 32484472
Sedation 56.09 38.87 36 5305 18490 32489695
Rheumatoid nodule 45.71 38.87 16 5325 2091 32506094
Diarrhoea 45.39 38.87 4 5337 364798 32143387
Bradypnoea 43.12 38.87 16 5325 2470 32505715
Electrocardiogram QT prolonged 42.92 38.87 42 5299 39599 32468586
Laryngeal dyspnoea 40.28 38.87 8 5333 109 32508076
Tachycardia 38.98 38.87 56 5285 79032 32429153

Pharmacologic Action:

SourceCodeDescription
ATC N05AA06 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Phenothiazines with aliphatic side-chain

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.92 Basic
pKa2 2.39 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(1A) dopamine receptor GPCR Ki 8.42 PDSP
D(2) dopamine receptor GPCR Ki 8.24 PDSP
5-hydroxytryptamine receptor 1A GPCR ANTAGONIST Ki 6.30 IUPHAR
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 8.80 IUPHAR
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST Ki 7.90 IUPHAR
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 7.20 IUPHAR
D(3) dopamine receptor GPCR Ki 8.60 PDSP
Muscarinic acetylcholine receptor M1 GPCR Ki 7.89 PDSP
Muscarinic acetylcholine receptor M2 GPCR Ki 7.38 PDSP
Muscarinic acetylcholine receptor M3 GPCR Ki 7.50 PDSP
Muscarinic acetylcholine receptor M4 GPCR Ki 7.92 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 7.46 PDSP
5-hydroxytryptamine receptor 3A Ion channel Ki 5.53 PDSP

External reference:

IDSource
D07307 KEGG_DRUG
C0056643 UMLSCUI
CHEBI:135379 CHEBI
CHEMBL2104153 ChEMBL_ID
DB09000 DRUGBANK_ID
C028457 MESH_SUPPLEMENTAL_RECORD_UI
62865 PUBCHEM_CID
84 IUPHAR_LIGAND_ID
1148 INN_ID
A2JGV5CNU4 UNII
21877 RXNORM
005507 NDDF

Pharmaceutical products:

None