acepromazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 73 | 61-00-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Acepromazine, a phenothiazine derivatives, was first used in the 1950s in the treatment of PSYCHOSES. Now, it is commonly used as tranquilizer/sedative agent in dogs, cats, horses, and other animals. It is thought to block dopamine receptors in the brain or inhibit the activity of dopamine in other ways.
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Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.10 | g | O |
| 50 | mg | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 55 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N05AA04 | NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Phenothiazines with aliphatic side-chain |
| MeSH PA | D014150 | Antipsychotic Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D015259 | Dopamine Agents |
| MeSH PA | D018492 | Dopamine Antagonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D011619 | Psychotropic Drugs |
| MeSH PA | D014149 | Tranquilizing Agents |
| CHEBI has role | CHEBI:37930 | phenothiazine antipsychotic drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cats | Control intractable animals during examination, treatment, grooming, x-ray and minor surgical procedures | Indication |
| Cats | Itching caused by skin irritation | Indication |
| Cats | Control vomiting associated with motion sickness | Indication |
| Dogs | Control intractable animals during examination, treatment, grooming, x-ray and minor surgical procedures | Indication |
| Dogs | Itching caused by skin irritation | Indication |
| Dogs | Control vomiting associated with motion sickness | Indication |
| Horses | Controll fractious animals during examination,treatment, loading and transportation | Indication |
| Horses | Local anesthesia for firing, castration, neurectomy, removal of skin tumors, ocular surgery and applying casts | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| PromAce Injectable | Boehringer lngelheim Animal Health USA Inc. | 1 |
| PromAce Tablets | Boehringer lngelheim Animal Health USA Inc. | 1 |
| Acepromazine Maleate Injection | Boehringer lngelheim Animal Health USA Inc. | 1 |
| PromAce | Boehringer lngelheim Animal Health USA Inc. | 1 |
| Acepromazine Maleate Injection | Elanco US Inc. | 1 |
| Acepromazine Maleate Injection | Boehringer lngelheim Animal Health USA Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.04 | Basic |
| pKa2 | 1.82 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| D(1A) dopamine receptor | GPCR | ANTAGONIST | DRUGBANK | DRUGBANK | |||||
| D(2) dopamine receptor | GPCR | ANTAGONIST | DRUGBANK | DRUGBANK | |||||
| Major prion protein | Surface antigen | EC50 | 5.30 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000167279 | NUI |
| D07065 | KEGG_DRUG |
| 627-70-3 | SECONDARY_CAS_RN |
| 1114057 | RXNORM |
| C0000959 | UMLSCUI |
| CHEBI:44932 | CHEBI |
| PMZ | PDB_CHEM_ID |
| CHEMBL39560 | ChEMBL_ID |
| D000075 | MESH_DESCRIPTOR_UI |
| DB01614 | DRUGBANK_ID |
| 667 | INN_ID |
| 3598-37-6 | SECONDARY_CAS_RN |
| 54EJ303F0R | UNII |
| 6077 | PUBCHEM_CID |
| 412076009 | SNOMEDCT_US |
| 96218000 | SNOMEDCT_US |
| CHEMBL1883146 | ChEMBL_ID |
| NOCODE | MMSL |
| 005220 | NDDF |
| 005221 | NDDF |
Pharmaceutical products:
None