acepromazine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 73 | 61-00-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Acepromazine, a phenothiazine derivatives, was first used in the 1950s in the treatment of PSYCHOSES. Now, it is commonly used as tranquilizer/sedative agent in dogs, cats, horses, and other animals. It is thought to block dopamine receptors in the brain or inhibit the activity of dopamine in other ways.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.10 | g | O |
| 50 | mg | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 55 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N05AA04 | NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Phenothiazines with aliphatic side-chain |
| MeSH PA | D014150 | Antipsychotic Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D015259 | Dopamine Agents |
| MeSH PA | D018492 | Dopamine Antagonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D011619 | Psychotropic Drugs |
| MeSH PA | D014149 | Tranquilizing Agents |
| CHEBI has role | CHEBI:37930 | phenothiazine antipsychotics |
Drug Use (View source of the data)
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.04 | Basic |
| pKa2 | 1.82 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Major prion protein | Surface antigen | EC50 | 5.30 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 54EJ303F0R | UNII |
| N0000167279 | NUI |
| D07065 | KEGG_DRUG |
| 627-70-3 | SECONDARY_CAS_RN |
| C0000959 | UMLSCUI |
| CHEBI:44932 | CHEBI |
| PMZ | PDB_CHEM_ID |
| CHEMBL39560 | ChEMBL_ID |
| 6077 | PUBCHEM_CID |
| DB01614 | DRUGBANK_ID |
| D000075 | MESH_DESCRIPTOR_UI |
| 667 | INN_ID |
| 155 | RXNORM |
| 005220 | NDDF |
| 96218000 | SNOMEDCT_US |
Pharmaceutical products:
None