acepromazine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
73 61-00-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • acetylpromazine
  • acepromazin
  • acepromazine
  • acetacin
  • acetazin
  • acetazine
  • acetopromazine
  • azepromazine
  • acetopromazine maleate
  • acetopromazine maleate salt
Acepromazine, a phenothiazine derivatives, was first used in the 1950s in the treatment of PSYCHOSES. Now, it is commonly used as tranquilizer/sedative agent in dogs, cats, horses, and other animals. It is thought to block dopamine receptors in the brain or inhibit the activity of dopamine in other ways.
  • Molecular weight: 326.46
  • Formula: C19H22N2OS
  • CLOGP: 4.38
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 23.55
  • ALOGS: -4.52
  • ROTB: 5

Drug dosage:

DoseUnitRoute
0.10 g O
50 mg P

ADMET properties:

PropertyValueReference
BA (Bioavailability) 55 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AA04 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Phenothiazines with aliphatic side-chain
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D015259 Dopamine Agents
MeSH PA D018492 Dopamine Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:37930 phenothiazine antipsychotics

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.04 Basic
pKa2 1.82 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Major prion protein Surface antigen EC50 5.30 CHEMBL

External reference:

IDSource
54EJ303F0R UNII
N0000167279 NUI
D07065 KEGG_DRUG
627-70-3 SECONDARY_CAS_RN
C0000959 UMLSCUI
CHEBI:44932 CHEBI
PMZ PDB_CHEM_ID
CHEMBL39560 ChEMBL_ID
6077 PUBCHEM_CID
DB01614 DRUGBANK_ID
D000075 MESH_DESCRIPTOR_UI
667 INN_ID
155 RXNORM
005220 NDDF
96218000 SNOMEDCT_US

Pharmaceutical products:

None