colforsin daropate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	729	138605-00-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: colforsin dapropate hydrochloride colforsin dapropate colforsin daropate hydrochloride colforsin daropate colforsin dapropate HCl colforsin daropate HCl	Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland. Molecular weight: 509.64 Formula: C27H43NO8 CLOGP: 2.52 LIPINSKI: 1 HAC: 9 HDO: 2 TPSA: 122.60 ALOGS: -3.33 ROTB: 8

Molecule

Description

Molfile Inchi Smiles

Synonyms:

colforsin dapropate hydrochloride
colforsin dapropate
colforsin daropate hydrochloride
colforsin daropate
colforsin dapropate HCl
colforsin daropate HCl

Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.

Molecular weight: 509.64
Formula: C27H43NO8
CLOGP: 2.52
LIPINSKI: 1
HAC: 9
HDO: 2
TPSA: 122.60
ALOGS: -3.33
ROTB: 8

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D000276	Adjuvants, Immunologic
MeSH PA	D018927	Anti-Asthmatic Agents
MeSH PA	D001993	Bronchodilator Agents
MeSH PA	D002316	Cardiotonic Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D007155	Immunologic Factors
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D020011	Protective Agents
MeSH PA	D019141	Respiratory System Agents
MeSH PA	D014665	Vasodilator Agents
CHEBI has role	CHEBI:35620	vasodilator agents
CHEBI has role	CHEBI:35674	antihypertensive drugs
CHEBI has role	CHEBI:38147	cardiotonic drugs
CHEBI has role	CHEBI:78548	adenylate cyclase agonists
CHEBI has role	CHEBI:50427	platelet aggregation inhibitors
CHEBI has role	CHEBI:64946	anti-AIDS agent
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:78547	protein kinase A agonists

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.82	acidic
pKa2	8.74	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Adenylate cyclase type 1	Enzyme	Q08828	ADCY1_HUMAN	IC50	7.39	CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III)	Ion channel	P35498 Q99250 Q9NY46	SCN1A_HUMAN SCN2A_HUMAN SCN3A_HUMAN	IC50	4.22	CHEMBL
Solute carrier family 2, facilitated glucose transporter member 1	Transporter	P11166	GTR1_HUMAN	Kd	5.30	CHEMBL
Adenylate cyclase type 8	Enzyme	P40145	ADCY8_HUMAN	EC50	7.03	CHEMBL
Adenylate cyclase type 1	Enzyme		ADCY1_BOVIN	Kd	7.54	CHEMBL

External reference:

ID	Source
D01697	KEGG_DRUG
113462-26-3	SECONDARY_CAS_RN
4033874	VANDF
CHEBI:31429	CHEBI
CHEBI:42471	CHEBI
C122001	MESH_SUPPLEMENTAL_RECORD_UI
DB02587	DRUGBANK_ID
007852	NDDF
C0909725	UMLSCUI
C0917964	UMLSCUI
CHEMBL52606	ChEMBL_ID
444029	PUBCHEM_CID
5326	INN_ID
66575-29-9	SECONDARY_CAS_RN
47936	PUBCHEM_CID
D005576	MESH_DESCRIPTOR_UI
1196KQZ976	UNII
1F7A44V6OU	UNII

Pharmaceutical products:

None