All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

colestipol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	728	50925-79-6

Description:

Molecule	Description
Synonyms: colestipol cholestabyl cholestipol colestipol hydrochloride colestipol HCl	Highly crosslinked and insoluble basic anion exchange resin used as anticholesteremic. It may also may reduce triglyceride levels. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
20	g	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	4	Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
April 4, 1977	FDA	PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Diarrhoea	138.95	18.44	228	5559	938962	89683698
Product physical issue	94.23	18.44	28	5759	5632	90617028
Fistula	52.51	18.44	22	5765	12067	90610593
Product dose omission issue	45.60	18.44	73	5714	291614	90331046
Rectal fissure	43.16	18.44	10	5777	764	90621896
Mucous stools	42.31	18.44	15	5772	5256	90617404
Feeding intolerance	40.47	18.44	10	5777	1004	90621656
Intestinal obstruction	36.31	18.44	25	5762	37106	90585554
Vaginal abscess	35.59	18.44	8	5779	534	90622126
Infusion site streaking	34.95	18.44	8	5779	579	90622081
Anal skin tags	33.78	18.44	8	5779	672	90621988
Cholangitis sclerosing	32.71	18.44	10	5777	2211	90620449
Dehydration	32.19	18.44	50	5737	194397	90428263
Procedural anxiety	31.95	18.44	8	5779	848	90621812
Vitamin D increased	31.16	18.44	8	5779	938	90621722
Gastrointestinal ulcer	30.39	18.44	10	5777	2801	90619859
Clostridium difficile infection	29.89	18.44	22	5765	36223	90586437
Haematocrit increased	29.50	18.44	10	5777	3068	90619592
Lactose intolerance	28.62	18.44	10	5777	3359	90619301
Haemorrhoids	28.54	18.44	19	5768	26683	90595977
Product use complaint	28.15	18.44	10	5777	3523	90619137
Oesophageal ulcer	28.01	18.44	11	5776	5108	90617552
Poor quality product administered	26.92	18.44	10	5777	3998	90618662
Oesophageal pain	26.07	18.44	10	5777	4364	90618296
Incontinence	25.97	18.44	14	5773	13421	90609239
Gingival swelling	24.75	18.44	10	5777	5003	90617657
Fatigue	23.93	18.44	140	5647	1153883	89468777
Dermatitis exfoliative generalised	23.69	18.44	10	5777	5583	90617077
Cystic fibrosis	23.45	18.44	9	5778	3932	90618728
Proctalgia	23.03	18.44	11	5776	8187	90614473
Defaecation urgency	22.63	18.44	10	5777	6232	90616428
White blood cell disorder	22.15	18.44	8	5779	2956	90619704
Anorectal discomfort	21.97	18.44	8	5779	3026	90619634
Blood magnesium decreased	21.33	18.44	13	5774	15680	90606980
Flatulence	21.15	18.44	19	5768	41348	90581312
Neuropathy peripheral	20.97	18.44	34	5753	136936	90485724
Haemoglobin increased	20.90	18.44	10	5777	7471	90615189
Large intestinal ulcer	19.98	18.44	8	5779	3909	90618751
Frequent bowel movements	19.49	18.44	21	5766	56914	90565746
Serum ferritin decreased	19.32	18.44	7	5780	2607	90620053
Diverticulum	18.99	18.44	11	5776	12102	90610558

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Diarrhoea	65.17	21.51	87	1684	460762	42158802
Intestinal stenosis	30.26	21.51	9	1762	2795	42616769

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Diarrhoea	111.27	17.54	210	5759	1139295	109444035
Fistula	57.74	17.54	24	5945	15275	110568055
Product physical issue	49.50	17.54	16	5953	5020	110578310
Rectal fissure	46.08	17.54	11	5958	1133	110582197
Mucous stools	40.94	17.54	15	5954	6832	110576498
Feeding intolerance	40.60	17.54	10	5959	1174	110582156
Intestinal obstruction	38.68	17.54	28	5941	53199	110530131
Vaginal abscess	37.68	17.54	8	5961	485	110582845
Anal skin tags	36.59	17.54	8	5961	557	110582773
Infusion site streaking	36.25	17.54	8	5961	582	110582748
Cholangitis sclerosing	33.66	17.54	11	5958	3571	110579759
Vitamin D increased	33.31	17.54	8	5961	845	110582485
Procedural anxiety	33.24	17.54	8	5961	853	110582477
Oesophageal pain	29.80	17.54	11	5958	5114	110578216
Lactose intolerance	28.02	17.54	9	5960	2767	110580563
Gastrointestinal ulcer	27.96	17.54	10	5959	4250	110579080
Intestinal stenosis	26.97	17.54	10	5959	4705	110578625
Haematocrit increased	26.48	17.54	10	5959	4949	110578381
COVID-19	25.91	17.54	47	5922	245013	110338317
Gingival swelling	25.78	17.54	10	5959	5320	110578010
Product use complaint	25.24	17.54	9	5960	3794	110579536
Oesophageal ulcer	25.10	17.54	11	5958	7953	110575377
Large intestinal ulcer	25.03	17.54	10	5959	5751	110577579
Intestinal resection	24.95	17.54	9	5960	3920	110579410
Product dose omission issue	24.74	17.54	54	5915	321728	110261602
Haemorrhoids	24.18	17.54	18	5951	35654	110547676
Clostridium difficile infection	24.05	17.54	21	5948	52108	110531222
Blood magnesium decreased	22.97	17.54	14	5955	19982	110563348
Proctalgia	22.59	17.54	12	5957	13210	110570120
Fatigue	22.12	17.54	126	5843	1215832	109367498
Dehydration	21.58	17.54	47	5922	279464	110303866
White blood cell disorder	21.40	17.54	8	5961	3851	110579479
Defaecation urgency	21.01	17.54	10	5959	8737	110574593
Anorectal discomfort	20.88	17.54	8	5961	4118	110579212
Diverticulum	20.79	17.54	12	5957	15514	110567816
Haemoglobin increased	20.59	17.54	10	5959	9137	110574193
Flatulence	20.12	17.54	19	5950	52130	110531200
Incontinence	20.02	17.54	12	5957	16623	110566707
Cystic fibrosis	19.82	17.54	8	5961	4723	110578607
Serum ferritin decreased	19.50	17.54	7	5962	3007	110580323
Dermatitis exfoliative generalised	18.86	17.54	10	5959	10962	110572368
Frequent bowel movements	18.49	17.54	21	5948	71369	110511961
Fear of injection	17.85	17.54	9	5960	8902	110574428

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C10AC02	CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, PLAIN Bile acid sequestrants
FDA MoA	N0000175365	Bile-acid Binding Activity
MeSH PA	D000837	Anion Exchange Resins
MeSH PA	D000960	Hypolipidemic Agents
MeSH PA	D000963	Antimetabolites
MeSH PA	D057847	Lipid Regulating Agents
MeSH PA	D064449	Sequestering Agents
CHEBI has role	CHEBI:35821	anticholesteremic drug
FDA EPC	N0000180292	Bile Acid Sequestrant
CHEBI has role	CHEBI:35554	cardiovascular drug
CHEBI has role	CHEBI:35610	antineoplastic agent

Related Drugs by ATC class:

C10AC Bile acid sequestrants 3 drugs

cholestyraminecolesevelamcolextran

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypercholesterolemia	indication	13644009
Hyperlipidemia	indication	55822004	DOID:1168
Poisoning by digitalis glycoside	off-label use	12876009
Biliary Obstruction with Pruritus	off-label use
Constipation	contraindication	14760008	DOID:2089
Blood coagulation disorder	contraindication	64779008	DOID:1247
Hemorrhoids	contraindication	70153002	DOID:9746
Kidney disease	contraindication	90708001	DOID:557
Calculus in biliary tract	contraindication	266474003
Complete Biliary Obstruction	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4019692	VUID
N0000147784	NUI
D02113	KEGG_DRUG
37296-80-3	SECONDARY_CAS_RN
104485	RXNORM
C0009279	UMLSCUI
CHEBI:3814	CHEBI
CHEMBL1201474	ChEMBL_ID
CHEMBL1909303	ChEMBL_ID
DB00375	DRUGBANK_ID
D003084	MESH_DESCRIPTOR_UI
2738	INN_ID
K50N755924	UNII
4494	MMSL
83640	MMSL
d00744	MMSL
001217	NDDF
004708	NDDF
372811005	SNOMEDCT_US
55316001	SNOMEDCT_US
66971004	SNOMEDCT_US
3084661	PUBCHEM_CID
26658-42-4	SECONDARY_CAS_RN
4018086	VANDF
4019692	VANDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Colestid	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0260	GRANULE, FOR SUSPENSION	5 g	ORAL	NDA	18 sections
Flavored Colestid	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0370	GRANULE, FOR SUSPENSION	5 g	ORAL	NDA	18 sections
Colestid	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0450	TABLET	1 g	ORAL	NDA	18 sections
COLESTIPOL HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0115-5211	TABLET, FILM COATED	1 g	ORAL	ANDA	19 sections
COLESTIPOL HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0115-5212	SUSPENSION	5 g	ORAL	ANDA	14 sections
COLESTIPOL HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0115-5213	SUSPENSION	5 g	ORAL	ANDA	14 sections
Colestipol Hydrochloride	Human Prescription Drug Label	1	42799-115	TABLET	1 g	ORAL	ANDA	16 sections
Colestipol Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	50742-284	TABLET, FILM COATED	1 g	ORAL	ANDA	19 sections
Colestipol Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	50742-284	TABLET, FILM COATED	1 g	ORAL	ANDA	19 sections
Colestipol Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	54868-0610	TABLET	1 g	ORAL	NDA authorized generic	19 sections
Colestipol Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	59762-0260	GRANULE, FOR SUSPENSION	5 g	ORAL	NDA authorized generic	18 sections
Colestipol Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	59762-0450	TABLET	1 g	ORAL	NDA AUTHORIZED GENERIC	18 sections
Colestipol Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	60687-715	TABLET, FILM COATED	1 g	ORAL	ANDA	19 sections
Colestipol Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	60687-715	TABLET, FILM COATED	1 g	ORAL	ANDA	19 sections
COLESTIPOL HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	62559-395	TABLET, FILM COATED	1 g	ORAL	ANDA	16 sections
Colestipol Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	68151-4361	TABLET	1 g	ORAL	NDA AUTHORIZED GENERIC	18 sections
Colestipol hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	70710-1467	TABLET, FILM COATED	1 g	ORAL	ANDA	16 sections
Colestipol hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	70771-1653	TABLET, FILM COATED	1 g	ORAL	ANDA	1 sections