colestipol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
728 50925-79-6

Description:

MoleculeDescription

Synonyms:

  • colestipol
  • cholestabyl
  • cholestipol
  • colestipol hydrochloride
  • colestipol HCl
Highly crosslinked and insoluble basic anion exchange resin used as anticholesteremic. It may also may reduce triglyceride levels.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
20 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
April 4, 1977 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Diarrhoea 138.95 18.44 228 5559 938962 89683698
Product physical issue 94.23 18.44 28 5759 5632 90617028
Fistula 52.51 18.44 22 5765 12067 90610593
Product dose omission issue 45.60 18.44 73 5714 291614 90331046
Rectal fissure 43.16 18.44 10 5777 764 90621896
Mucous stools 42.31 18.44 15 5772 5256 90617404
Feeding intolerance 40.47 18.44 10 5777 1004 90621656
Intestinal obstruction 36.31 18.44 25 5762 37106 90585554
Vaginal abscess 35.59 18.44 8 5779 534 90622126
Infusion site streaking 34.95 18.44 8 5779 579 90622081
Anal skin tags 33.78 18.44 8 5779 672 90621988
Cholangitis sclerosing 32.71 18.44 10 5777 2211 90620449
Dehydration 32.19 18.44 50 5737 194397 90428263
Procedural anxiety 31.95 18.44 8 5779 848 90621812
Vitamin D increased 31.16 18.44 8 5779 938 90621722
Gastrointestinal ulcer 30.39 18.44 10 5777 2801 90619859
Clostridium difficile infection 29.89 18.44 22 5765 36223 90586437
Haematocrit increased 29.50 18.44 10 5777 3068 90619592
Lactose intolerance 28.62 18.44 10 5777 3359 90619301
Haemorrhoids 28.54 18.44 19 5768 26683 90595977
Product use complaint 28.15 18.44 10 5777 3523 90619137
Oesophageal ulcer 28.01 18.44 11 5776 5108 90617552
Poor quality product administered 26.92 18.44 10 5777 3998 90618662
Oesophageal pain 26.07 18.44 10 5777 4364 90618296
Incontinence 25.97 18.44 14 5773 13421 90609239
Gingival swelling 24.75 18.44 10 5777 5003 90617657
Fatigue 23.93 18.44 140 5647 1153883 89468777
Dermatitis exfoliative generalised 23.69 18.44 10 5777 5583 90617077
Cystic fibrosis 23.45 18.44 9 5778 3932 90618728
Proctalgia 23.03 18.44 11 5776 8187 90614473
Defaecation urgency 22.63 18.44 10 5777 6232 90616428
White blood cell disorder 22.15 18.44 8 5779 2956 90619704
Anorectal discomfort 21.97 18.44 8 5779 3026 90619634
Blood magnesium decreased 21.33 18.44 13 5774 15680 90606980
Flatulence 21.15 18.44 19 5768 41348 90581312
Neuropathy peripheral 20.97 18.44 34 5753 136936 90485724
Haemoglobin increased 20.90 18.44 10 5777 7471 90615189
Large intestinal ulcer 19.98 18.44 8 5779 3909 90618751
Frequent bowel movements 19.49 18.44 21 5766 56914 90565746
Serum ferritin decreased 19.32 18.44 7 5780 2607 90620053
Diverticulum 18.99 18.44 11 5776 12102 90610558

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Diarrhoea 65.17 21.51 87 1684 460762 42158802
Intestinal stenosis 30.26 21.51 9 1762 2795 42616769

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Diarrhoea 111.27 17.54 210 5759 1139295 109444035
Fistula 57.74 17.54 24 5945 15275 110568055
Product physical issue 49.50 17.54 16 5953 5020 110578310
Rectal fissure 46.08 17.54 11 5958 1133 110582197
Mucous stools 40.94 17.54 15 5954 6832 110576498
Feeding intolerance 40.60 17.54 10 5959 1174 110582156
Intestinal obstruction 38.68 17.54 28 5941 53199 110530131
Vaginal abscess 37.68 17.54 8 5961 485 110582845
Anal skin tags 36.59 17.54 8 5961 557 110582773
Infusion site streaking 36.25 17.54 8 5961 582 110582748
Cholangitis sclerosing 33.66 17.54 11 5958 3571 110579759
Vitamin D increased 33.31 17.54 8 5961 845 110582485
Procedural anxiety 33.24 17.54 8 5961 853 110582477
Oesophageal pain 29.80 17.54 11 5958 5114 110578216
Lactose intolerance 28.02 17.54 9 5960 2767 110580563
Gastrointestinal ulcer 27.96 17.54 10 5959 4250 110579080
Intestinal stenosis 26.97 17.54 10 5959 4705 110578625
Haematocrit increased 26.48 17.54 10 5959 4949 110578381
COVID-19 25.91 17.54 47 5922 245013 110338317
Gingival swelling 25.78 17.54 10 5959 5320 110578010
Product use complaint 25.24 17.54 9 5960 3794 110579536
Oesophageal ulcer 25.10 17.54 11 5958 7953 110575377
Large intestinal ulcer 25.03 17.54 10 5959 5751 110577579
Intestinal resection 24.95 17.54 9 5960 3920 110579410
Product dose omission issue 24.74 17.54 54 5915 321728 110261602
Haemorrhoids 24.18 17.54 18 5951 35654 110547676
Clostridium difficile infection 24.05 17.54 21 5948 52108 110531222
Blood magnesium decreased 22.97 17.54 14 5955 19982 110563348
Proctalgia 22.59 17.54 12 5957 13210 110570120
Fatigue 22.12 17.54 126 5843 1215832 109367498
Dehydration 21.58 17.54 47 5922 279464 110303866
White blood cell disorder 21.40 17.54 8 5961 3851 110579479
Defaecation urgency 21.01 17.54 10 5959 8737 110574593
Anorectal discomfort 20.88 17.54 8 5961 4118 110579212
Diverticulum 20.79 17.54 12 5957 15514 110567816
Haemoglobin increased 20.59 17.54 10 5959 9137 110574193
Flatulence 20.12 17.54 19 5950 52130 110531200
Incontinence 20.02 17.54 12 5957 16623 110566707
Cystic fibrosis 19.82 17.54 8 5961 4723 110578607
Serum ferritin decreased 19.50 17.54 7 5962 3007 110580323
Dermatitis exfoliative generalised 18.86 17.54 10 5959 10962 110572368
Frequent bowel movements 18.49 17.54 21 5948 71369 110511961
Fear of injection 17.85 17.54 9 5960 8902 110574428

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C10AC02 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
Bile acid sequestrants
FDA MoA N0000175365 Bile-acid Binding Activity
MeSH PA D000837 Anion Exchange Resins
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D000963 Antimetabolites
MeSH PA D057847 Lipid Regulating Agents
MeSH PA D064449 Sequestering Agents
CHEBI has role CHEBI:35821 anticholesteremic drug
FDA EPC N0000180292 Bile Acid Sequestrant
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent

Related Drugs by ATC class:

C10AC Bile acid sequestrants 3 drugs
cholestyraminecolesevelamcolextran

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypercholesterolemia indication 13644009
Hyperlipidemia indication 55822004 DOID:1168
Poisoning by digitalis glycoside off-label use 12876009
Biliary Obstruction with Pruritus off-label use
Constipation contraindication 14760008 DOID:2089
Blood coagulation disorder contraindication 64779008 DOID:1247
Hemorrhoids contraindication 70153002 DOID:9746
Kidney disease contraindication 90708001 DOID:557
Calculus in biliary tract contraindication 266474003
Complete Biliary Obstruction contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019692 VUID
N0000147784 NUI
D02113 KEGG_DRUG
37296-80-3 SECONDARY_CAS_RN
104485 RXNORM
C0009279 UMLSCUI
CHEBI:3814 CHEBI
CHEMBL1201474 ChEMBL_ID
CHEMBL1909303 ChEMBL_ID
DB00375 DRUGBANK_ID
D003084 MESH_DESCRIPTOR_UI
2738 INN_ID
K50N755924 UNII
4494 MMSL
83640 MMSL
d00744 MMSL
001217 NDDF
004708 NDDF
372811005 SNOMEDCT_US
55316001 SNOMEDCT_US
66971004 SNOMEDCT_US
3084661 PUBCHEM_CID
26658-42-4 SECONDARY_CAS_RN
4018086 VANDF
4019692 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Colestid HUMAN PRESCRIPTION DRUG LABEL 1 0009-0260 GRANULE, FOR SUSPENSION 5 g ORAL NDA 18 sections
Flavored Colestid HUMAN PRESCRIPTION DRUG LABEL 1 0009-0370 GRANULE, FOR SUSPENSION 5 g ORAL NDA 18 sections
Colestid HUMAN PRESCRIPTION DRUG LABEL 1 0009-0450 TABLET 1 g ORAL NDA 18 sections
COLESTIPOL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0115-5211 TABLET, FILM COATED 1 g ORAL ANDA 19 sections
COLESTIPOL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0115-5212 SUSPENSION 5 g ORAL ANDA 14 sections
COLESTIPOL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0115-5213 SUSPENSION 5 g ORAL ANDA 14 sections
Colestipol Hydrochloride Human Prescription Drug Label 1 42799-115 TABLET 1 g ORAL ANDA 16 sections
Colestipol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50742-284 TABLET, FILM COATED 1 g ORAL ANDA 19 sections
Colestipol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50742-284 TABLET, FILM COATED 1 g ORAL ANDA 19 sections
Colestipol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 54868-0610 TABLET 1 g ORAL NDA authorized generic 19 sections
Colestipol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 59762-0260 GRANULE, FOR SUSPENSION 5 g ORAL NDA authorized generic 18 sections
Colestipol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 59762-0450 TABLET 1 g ORAL NDA AUTHORIZED GENERIC 18 sections
Colestipol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 60687-715 TABLET, FILM COATED 1 g ORAL ANDA 19 sections
Colestipol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 60687-715 TABLET, FILM COATED 1 g ORAL ANDA 19 sections
COLESTIPOL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 62559-395 TABLET, FILM COATED 1 g ORAL ANDA 16 sections
Colestipol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 68151-4361 TABLET 1 g ORAL NDA AUTHORIZED GENERIC 18 sections
Colestipol hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 70710-1467 TABLET, FILM COATED 1 g ORAL ANDA 16 sections
Colestipol hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 70771-1653 TABLET, FILM COATED 1 g ORAL ANDA 1 sections