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| Stem definition | Drug id | CAS RN |
|---|---|---|
| 727 | 11041-12-6 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
| Dose | Unit | Route |
|---|---|---|
| 14 | g | O |
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Bocci G, Oprea TI, Benet LZ |
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 3, 1973 | FDA | BRISTOL MYERS |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Diarrhoea | 214.91 | 13.22 | 506 | 16116 | 938684 | 89673141 |
| Product taste abnormal | 104.85 | 13.22 | 32 | 16590 | 2428 | 90609397 |
| Product physical consistency issue | 94.30 | 13.22 | 24 | 16598 | 930 | 90610895 |
| Product solubility abnormal | 78.98 | 13.22 | 21 | 16601 | 968 | 90610857 |
| Frequent bowel movements | 60.75 | 13.22 | 63 | 16559 | 56872 | 90554953 |
| Colitis | 60.01 | 13.22 | 69 | 16553 | 69873 | 90541952 |
| Product residue present | 58.83 | 13.22 | 24 | 16598 | 4267 | 90607558 |
| Abdominal pain | 51.03 | 13.22 | 174 | 16448 | 395547 | 90216278 |
| Glossodynia | 47.17 | 13.22 | 3 | 16619 | 321776 | 90290049 |
| Bowel movement irregularity | 46.23 | 13.22 | 23 | 16599 | 6491 | 90605334 |
| Abdominal distension | 45.46 | 13.22 | 84 | 16538 | 130517 | 90481308 |
| Drug ineffective for unapproved indication | 44.60 | 13.22 | 58 | 16564 | 66586 | 90545239 |
| Systemic lupus erythematosus | 43.74 | 13.22 | 7 | 16615 | 361889 | 90249936 |
| Laparotomy | 43.22 | 13.22 | 11 | 16611 | 426 | 90611399 |
| Bulimia nervosa | 41.45 | 13.22 | 11 | 16611 | 503 | 90611322 |
| Intestinal obstruction | 41.26 | 13.22 | 42 | 16580 | 37089 | 90574736 |
| Contraindicated product administered | 39.11 | 13.22 | 6 | 16616 | 320133 | 90291692 |
| Wound | 38.61 | 13.22 | 5 | 16617 | 302975 | 90308850 |
| Faecal calprotectin increased | 37.23 | 13.22 | 17 | 16605 | 3970 | 90607855 |
| Clostridium difficile infection | 36.68 | 13.22 | 39 | 16583 | 36206 | 90575619 |
| Gastrointestinal wall thickening | 36.46 | 13.22 | 14 | 16608 | 2123 | 90609702 |
| Product use complaint | 35.96 | 13.22 | 16 | 16606 | 3517 | 90608308 |
| Rheumatoid arthritis | 34.05 | 13.22 | 12 | 16610 | 362602 | 90249223 |
| Intestinal stenosis | 33.88 | 13.22 | 15 | 16607 | 3259 | 90608566 |
| Intestinal anastomosis | 30.97 | 13.22 | 10 | 16612 | 912 | 90610913 |
| Flatulence | 30.84 | 13.22 | 38 | 16584 | 41329 | 90570496 |
| Helicobacter infection | 30.76 | 13.22 | 3 | 16619 | 226847 | 90384978 |
| Sacroiliitis | 30.25 | 13.22 | 15 | 16607 | 4204 | 90607621 |
| Constipation | 29.91 | 13.22 | 116 | 16506 | 280279 | 90331546 |
| Toxicity to various agents | 29.76 | 13.22 | 8 | 16614 | 287838 | 90323987 |
| Cholangitis sclerosing | 29.01 | 13.22 | 12 | 16610 | 2209 | 90609616 |
| Intestinal resection | 28.97 | 13.22 | 13 | 16609 | 2914 | 90608911 |
| Intestinal fibrosis | 28.71 | 13.22 | 7 | 16615 | 227 | 90611598 |
| Mesenteric vein thrombosis | 28.38 | 13.22 | 10 | 16612 | 1191 | 90610634 |
| Rash macular | 27.88 | 13.22 | 31 | 16591 | 30249 | 90581576 |
| Ileal stenosis | 27.74 | 13.22 | 12 | 16610 | 2466 | 90609359 |
| Bile acid malabsorption | 27.10 | 13.22 | 7 | 16615 | 288 | 90611537 |
| Anal incontinence | 27.02 | 13.22 | 23 | 16599 | 16207 | 90595618 |
| Folliculitis | 26.94 | 13.22 | 3 | 16619 | 204350 | 90407475 |
| Therapeutic product effect decreased | 26.37 | 13.22 | 9 | 16613 | 277562 | 90334263 |
| Proctalgia | 25.74 | 13.22 | 17 | 16605 | 8181 | 90603644 |
| Post procedural diarrhoea | 25.39 | 13.22 | 7 | 16615 | 370 | 90611455 |
| Small intestinal obstruction | 25.39 | 13.22 | 25 | 16597 | 21209 | 90590616 |
| Cerebral venous sinus thrombosis | 24.95 | 13.22 | 11 | 16611 | 2365 | 90609460 |
| Functional gastrointestinal disorder | 24.92 | 13.22 | 14 | 16608 | 5048 | 90606777 |
| Blood alkaline phosphatase increased | 24.90 | 13.22 | 37 | 16585 | 48042 | 90563783 |
| Ophthalmoplegia | 24.72 | 13.22 | 10 | 16612 | 1739 | 90610086 |
| Type 2 diabetes mellitus | 24.38 | 13.22 | 4 | 16618 | 203240 | 90408585 |
| Terminal ileitis | 24.26 | 13.22 | 9 | 16613 | 1241 | 90610584 |
| Foreign body in throat | 23.75 | 13.22 | 7 | 16615 | 471 | 90611354 |
| Off label use | 23.33 | 13.22 | 306 | 16316 | 1101946 | 89509879 |
| Impaired healing | 23.29 | 13.22 | 7 | 16615 | 234192 | 90377633 |
| Nephrolithiasis | 22.92 | 13.22 | 36 | 16586 | 49049 | 90562776 |
| Product odour abnormal | 22.26 | 13.22 | 9 | 16613 | 1562 | 90610263 |
| Gastroenteritis | 22.03 | 13.22 | 27 | 16595 | 29202 | 90582623 |
| Ill-defined disorder | 21.39 | 13.22 | 4 | 16618 | 184887 | 90426938 |
| Jaundice | 21.28 | 13.22 | 28 | 16594 | 32489 | 90579336 |
| Stomatitis | 21.21 | 13.22 | 12 | 16610 | 274686 | 90337139 |
| Suprapubic pain | 20.93 | 13.22 | 7 | 16615 | 713 | 90611112 |
| Drug level decreased | 20.89 | 13.22 | 16 | 16606 | 9714 | 90602111 |
| Arthropathy | 20.68 | 13.22 | 22 | 16600 | 366220 | 90245605 |
| Serum ferritin increased | 20.07 | 13.22 | 14 | 16608 | 7367 | 90604458 |
| Pleural rub | 19.10 | 13.22 | 4 | 16618 | 64 | 90611761 |
| Anal fissure | 18.96 | 13.22 | 12 | 16610 | 5373 | 90606452 |
| Enterocutaneous fistula | 18.87 | 13.22 | 8 | 16614 | 1566 | 90610259 |
| Colectomy | 18.47 | 13.22 | 10 | 16612 | 3357 | 90608468 |
| Cystitis | 18.46 | 13.22 | 39 | 16583 | 66679 | 90545146 |
| Infusion related reaction | 18.45 | 13.22 | 30 | 16592 | 416750 | 90195075 |
| Retching | 18.30 | 13.22 | 20 | 16602 | 19139 | 90592686 |
| Vascular device infection | 18.00 | 13.22 | 16 | 16606 | 11936 | 90599889 |
| Dehydration | 17.98 | 13.22 | 77 | 16545 | 194370 | 90417455 |
| Lower respiratory tract infection | 17.89 | 13.22 | 12 | 16610 | 250647 | 90361178 |
| Plasma cell myeloma | 17.77 | 13.22 | 29 | 16593 | 40799 | 90571026 |
| Therapeutic reaction time decreased | 17.69 | 13.22 | 10 | 16612 | 3648 | 90608177 |
| Crohn's disease | 17.56 | 13.22 | 11 | 16611 | 4840 | 90606985 |
| Wheezing | 17.53 | 13.22 | 11 | 16611 | 238069 | 90373756 |
| Sarcoma | 17.51 | 13.22 | 6 | 16616 | 658 | 90611167 |
| Clostridium difficile colitis | 17.48 | 13.22 | 23 | 16599 | 26683 | 90585142 |
| Cholecystitis infective | 17.45 | 13.22 | 8 | 16614 | 1884 | 90609941 |
| Fibromyalgia | 17.43 | 13.22 | 8 | 16614 | 206261 | 90405564 |
| Colitis microscopic | 16.93 | 13.22 | 15 | 16607 | 11144 | 90600681 |
| Intestinal anastomosis complication | 16.90 | 13.22 | 5 | 16617 | 341 | 90611484 |
| Joint swelling | 16.53 | 13.22 | 43 | 16579 | 503257 | 90108568 |
| Urinary tract infection | 16.40 | 13.22 | 104 | 16518 | 305528 | 90306297 |
| Cholelithiasis | 16.07 | 13.22 | 32 | 16590 | 52474 | 90559351 |
| Alanine aminotransferase increased | 16.05 | 13.22 | 53 | 16569 | 118285 | 90493540 |
| Swelling | 16.02 | 13.22 | 33 | 16589 | 419025 | 90192800 |
| Hepatic steatosis | 15.75 | 13.22 | 26 | 16596 | 36919 | 90574906 |
| Aspartate aminotransferase increased | 15.70 | 13.22 | 48 | 16574 | 102889 | 90508936 |
| Weight decreased | 15.54 | 13.22 | 121 | 16501 | 379789 | 90232036 |
| Cholestatic liver injury | 14.73 | 13.22 | 9 | 16613 | 3788 | 90608037 |
| Remission not achieved | 14.27 | 13.22 | 4 | 16618 | 225 | 90611600 |
| Ileostomy | 14.16 | 13.22 | 7 | 16615 | 1947 | 90609878 |
| Tinnitus | 14.08 | 13.22 | 27 | 16595 | 43075 | 90568750 |
| Choking | 14.08 | 13.22 | 14 | 16608 | 12019 | 90599806 |
| Klebsiella infection | 13.97 | 13.22 | 13 | 16609 | 10284 | 90601541 |
| Thyrotoxic crisis | 13.91 | 13.22 | 6 | 16616 | 1225 | 90610600 |
| Discomfort | 13.84 | 13.22 | 18 | 16604 | 274317 | 90337508 |
| Blister | 13.64 | 13.22 | 16 | 16606 | 254982 | 90356843 |
| Diarrhoea haemorrhagic | 13.58 | 13.22 | 13 | 16609 | 10650 | 90601175 |
| Thyroidectomy | 13.51 | 13.22 | 6 | 16616 | 1313 | 90610512 |
| Benign vulval neoplasm | 13.51 | 13.22 | 3 | 16619 | 64 | 90611761 |
| Trance | 13.51 | 13.22 | 3 | 16619 | 64 | 90611761 |
| Gait inability | 13.47 | 13.22 | 5 | 16617 | 146451 | 90465374 |
| Neuropathy peripheral | 13.25 | 13.22 | 55 | 16567 | 136915 | 90474910 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Diarrhoea | 91.86 | 16.09 | 262 | 8983 | 460587 | 42151503 |
| Alveolar lung disease | 80.77 | 16.09 | 19 | 9226 | 443 | 42611647 |
| Pulmonary interstitial emphysema syndrome | 77.04 | 16.09 | 19 | 9226 | 544 | 42611546 |
| Diffuse alveolar damage | 52.01 | 16.09 | 20 | 9225 | 2572 | 42609518 |
| Intestinal intraepithelial lymphocytes increased | 48.95 | 16.09 | 11 | 9234 | 208 | 42611882 |
| Cryptitis | 45.84 | 16.09 | 11 | 9234 | 280 | 42611810 |
| Drug ineffective | 43.39 | 16.09 | 258 | 8987 | 629939 | 41982151 |
| Microvillous inclusion disease | 42.51 | 16.09 | 10 | 9235 | 233 | 42611857 |
| Nerve degeneration | 38.84 | 16.09 | 9 | 9236 | 196 | 42611894 |
| Intestinal obstruction | 38.79 | 16.09 | 38 | 9207 | 27120 | 42584970 |
| Apoptosis | 38.07 | 16.09 | 11 | 9234 | 582 | 42611508 |
| Product taste abnormal | 37.70 | 16.09 | 13 | 9232 | 1226 | 42610864 |
| Eosinophilic pneumonia | 36.96 | 16.09 | 19 | 9226 | 4855 | 42607235 |
| Probiotic therapy | 35.41 | 16.09 | 8 | 9237 | 155 | 42611935 |
| Faecal calprotectin increased | 32.29 | 16.09 | 15 | 9230 | 3079 | 42609011 |
| Abdominal rigidity | 31.13 | 16.09 | 12 | 9233 | 1553 | 42610537 |
| Hyperammonaemia | 30.95 | 16.09 | 20 | 9225 | 7846 | 42604244 |
| Hemivertebra | 30.78 | 16.09 | 7 | 9238 | 140 | 42611950 |
| Dehydration | 29.32 | 16.09 | 82 | 9163 | 141685 | 42470405 |
| Colitis microscopic | 29.04 | 16.09 | 14 | 9231 | 3119 | 42608971 |
| Vascular device infection | 27.72 | 16.09 | 17 | 9228 | 6093 | 42605997 |
| Gastric polyps | 26.63 | 16.09 | 11 | 9234 | 1704 | 42610386 |
| Small intestinal obstruction | 26.48 | 16.09 | 25 | 9220 | 17036 | 42595054 |
| Arthralgia | 26.43 | 16.09 | 101 | 9144 | 205137 | 42406953 |
| Erosive duodenitis | 26.18 | 16.09 | 11 | 9234 | 1778 | 42610312 |
| Transaminases abnormal | 25.46 | 16.09 | 7 | 9238 | 309 | 42611781 |
| Frequent bowel movements | 25.20 | 16.09 | 27 | 9218 | 21380 | 42590710 |
| Product solubility abnormal | 25.03 | 16.09 | 8 | 9237 | 596 | 42611494 |
| Biopsy | 24.93 | 16.09 | 7 | 9238 | 334 | 42611756 |
| Gastrointestinal anastomotic stenosis | 24.77 | 16.09 | 5 | 9240 | 55 | 42612035 |
| Abdominal pain | 24.74 | 16.09 | 94 | 9151 | 190377 | 42421713 |
| Hepatic enzyme abnormal | 24.58 | 16.09 | 13 | 9232 | 3519 | 42608571 |
| Fistula | 23.71 | 16.09 | 17 | 9228 | 7895 | 42604195 |
| Hepatic encephalopathy | 23.46 | 16.09 | 23 | 9222 | 16419 | 42595671 |
| Thyrotoxic crisis | 22.50 | 16.09 | 8 | 9237 | 826 | 42611264 |
| Enterocolonic fistula | 22.08 | 16.09 | 5 | 9240 | 98 | 42611992 |
| Escherichia urinary tract infection | 22.02 | 16.09 | 13 | 9232 | 4350 | 42607740 |
| Oesophageal atresia | 21.89 | 16.09 | 7 | 9238 | 522 | 42611568 |
| Renal mass | 21.81 | 16.09 | 10 | 9235 | 1992 | 42610098 |
| Glomerular filtration rate decreased | 21.72 | 16.09 | 22 | 9223 | 16329 | 42595761 |
| Renal neoplasm | 21.36 | 16.09 | 9 | 9236 | 1466 | 42610624 |
| Generalised oedema | 21.04 | 16.09 | 21 | 9224 | 15315 | 42596775 |
| Flatulence | 20.08 | 16.09 | 26 | 9219 | 25126 | 42586964 |
| Abdominal adhesions | 19.92 | 16.09 | 9 | 9236 | 1733 | 42610357 |
| Bacterial diarrhoea | 19.28 | 16.09 | 5 | 9240 | 176 | 42611914 |
| Intestinal stenosis | 18.61 | 16.09 | 10 | 9235 | 2794 | 42609296 |
| Toxicity to various agents | 18.03 | 16.09 | 14 | 9231 | 229122 | 42382968 |
| Bone density decreased | 17.89 | 16.09 | 9 | 9236 | 2197 | 42609893 |
| Lymphocyte count increased | 17.65 | 16.09 | 11 | 9234 | 4053 | 42608037 |
| Inappropriate schedule of product administration | 17.43 | 16.09 | 53 | 9192 | 95849 | 42516241 |
| Ileus | 17.21 | 16.09 | 21 | 9224 | 19118 | 42592972 |
| Rectal haemorrhage | 17.08 | 16.09 | 35 | 9210 | 49571 | 42562519 |
| Duodenitis | 16.79 | 16.09 | 12 | 9233 | 5544 | 42606546 |
| Hernia | 16.75 | 16.09 | 16 | 9229 | 11057 | 42601033 |
| Short-bowel syndrome | 16.26 | 16.09 | 5 | 9240 | 328 | 42611762 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Diarrhoea | 160.25 | 13.24 | 513 | 19686 | 1138992 | 109430108 |
| Pulmonary interstitial emphysema syndrome | 79.88 | 13.24 | 19 | 20180 | 556 | 110568544 |
| Alveolar lung disease | 75.66 | 13.24 | 19 | 20180 | 700 | 110568400 |
| Product solubility abnormal | 66.62 | 13.24 | 19 | 20180 | 1143 | 110567957 |
| Intestinal obstruction | 66.40 | 13.24 | 64 | 20135 | 53163 | 110515937 |
| Faecal calprotectin increased | 63.96 | 13.24 | 29 | 20170 | 6690 | 110562410 |
| Off label use | 58.58 | 13.24 | 470 | 19729 | 1499715 | 109069385 |
| Product physical consistency issue | 58.34 | 13.24 | 18 | 20181 | 1422 | 110567678 |
| Abdominal pain | 53.51 | 13.24 | 210 | 19989 | 512779 | 110056321 |
| Intestinal intraepithelial lymphocytes increased | 49.69 | 13.24 | 11 | 20188 | 232 | 110568868 |
| Diffuse alveolar damage | 46.71 | 13.24 | 20 | 20179 | 4027 | 110565073 |
| Vascular device infection | 46.62 | 13.24 | 32 | 20167 | 16480 | 110552620 |
| Small intestinal obstruction | 46.47 | 13.24 | 42 | 20157 | 32171 | 110536929 |
| Bowel movement irregularity | 45.63 | 13.24 | 24 | 20175 | 7636 | 110561464 |
| Cryptitis | 44.43 | 13.24 | 11 | 20188 | 382 | 110568718 |
| Drug ineffective | 44.19 | 13.24 | 447 | 19752 | 1520093 | 109049007 |
| Microvillous inclusion disease | 42.85 | 13.24 | 10 | 20189 | 269 | 110568831 |
| Drug ineffective for unapproved indication | 40.94 | 13.24 | 70 | 20129 | 102768 | 110466332 |
| Intestinal resection | 40.72 | 13.24 | 18 | 20181 | 3911 | 110565189 |
| Intestinal stenosis | 40.65 | 13.24 | 19 | 20180 | 4696 | 110564404 |
| Abdominal distension | 40.51 | 13.24 | 95 | 20104 | 175008 | 110394092 |
| Toxicity to various agents | 38.31 | 13.24 | 20 | 20179 | 480535 | 110088565 |
| Dehydration | 38.12 | 13.24 | 125 | 20074 | 279386 | 110289714 |
| Apoptosis | 37.74 | 13.24 | 11 | 20188 | 715 | 110568385 |
| Product taste abnormal | 37.54 | 13.24 | 15 | 20184 | 2537 | 110566563 |
| Nerve degeneration | 37.40 | 13.24 | 9 | 20190 | 277 | 110568823 |
| Thyrotoxic crisis | 37.15 | 13.24 | 14 | 20185 | 2026 | 110567074 |
| Probiotic therapy | 36.03 | 13.24 | 8 | 20191 | 171 | 110568929 |
| Frequent bowel movements | 35.82 | 13.24 | 54 | 20145 | 71336 | 110497764 |
| Eosinophilic pneumonia | 35.69 | 13.24 | 20 | 20179 | 7207 | 110561893 |
| Product residue present | 34.35 | 13.24 | 16 | 20183 | 3925 | 110565175 |
| Clostridium difficile infection | 32.90 | 13.24 | 44 | 20155 | 52085 | 110517015 |
| Therapeutic reaction time decreased | 32.76 | 13.24 | 17 | 20182 | 5262 | 110563838 |
| Anal fissure | 32.35 | 13.24 | 21 | 20178 | 9860 | 110559240 |
| Colitis | 32.30 | 13.24 | 63 | 20136 | 102260 | 110466840 |
| Product use complaint | 31.79 | 13.24 | 15 | 20184 | 3788 | 110565312 |
| Colitis microscopic | 31.00 | 13.24 | 23 | 20176 | 13371 | 110555729 |
| Abdominal adhesions | 30.40 | 13.24 | 15 | 20184 | 4175 | 110564925 |
| Cerebrovascular accident | 30.23 | 13.24 | 87 | 20112 | 181197 | 110387903 |
| Glossodynia | 29.77 | 13.24 | 3 | 20196 | 222001 | 110347099 |
| Flatulence | 28.40 | 13.24 | 41 | 20158 | 52108 | 110516992 |
| Blood pressure increased | 27.87 | 13.24 | 107 | 20092 | 258266 | 110310834 |
| Laparotomy | 27.18 | 13.24 | 8 | 20191 | 538 | 110568562 |
| Wound | 27.12 | 13.24 | 5 | 20194 | 234432 | 110334668 |
| Systemic lupus erythematosus | 26.25 | 13.24 | 7 | 20192 | 254331 | 110314769 |
| Rheumatoid arthritis | 26.12 | 13.24 | 11 | 20188 | 299602 | 110269498 |
| Inappropriate schedule of product administration | 25.91 | 13.24 | 89 | 20110 | 203548 | 110365552 |
| Psoriatic arthropathy | 25.52 | 13.24 | 3 | 20196 | 196758 | 110372342 |
| Erosive duodenitis | 25.38 | 13.24 | 11 | 20188 | 2280 | 110566820 |
| Enterocolonic fistula | 25.21 | 13.24 | 6 | 20193 | 176 | 110568924 |
| Hepatic encephalopathy | 24.52 | 13.24 | 28 | 20171 | 28228 | 110540872 |
| Gastrointestinal anastomotic stenosis | 24.26 | 13.24 | 5 | 20194 | 74 | 110569026 |
| Hyperammonaemia | 24.04 | 13.24 | 20 | 20179 | 13712 | 110555388 |
| Arthralgia | 23.84 | 13.24 | 232 | 19967 | 779400 | 109789700 |
| Gastric polyps | 23.84 | 13.24 | 14 | 20185 | 5509 | 110563591 |
| Cholangitis sclerosing | 23.57 | 13.24 | 12 | 20187 | 3570 | 110565530 |
| Contraindicated product administered | 23.50 | 13.24 | 8 | 20191 | 248259 | 110320841 |
| Mesenteric vein thrombosis | 23.49 | 13.24 | 10 | 20189 | 1985 | 110567115 |
| Gastrointestinal wall thickening | 23.44 | 13.24 | 12 | 20187 | 3611 | 110565489 |
| Abdominal rigidity | 23.26 | 13.24 | 12 | 20187 | 3668 | 110565432 |
| Intestinal anastomosis | 22.90 | 13.24 | 8 | 20191 | 933 | 110568167 |
| Functional gastrointestinal disorder | 22.66 | 13.24 | 14 | 20185 | 6035 | 110563065 |
| Poor venous access | 22.48 | 13.24 | 25 | 20174 | 24497 | 110544603 |
| Jaundice | 21.85 | 13.24 | 39 | 20160 | 59197 | 110509903 |
| Duodenitis | 21.75 | 13.24 | 16 | 20183 | 9180 | 110559920 |
| Terminal ileitis | 21.70 | 13.24 | 9 | 20190 | 1675 | 110567425 |
| Colectomy | 21.31 | 13.24 | 12 | 20187 | 4366 | 110564734 |
| Nephrolithiasis | 21.17 | 13.24 | 41 | 20158 | 66171 | 110502929 |
| Biopsy | 20.75 | 13.24 | 7 | 20192 | 735 | 110568365 |
| Drug level decreased | 20.71 | 13.24 | 21 | 20178 | 18527 | 110550573 |
| Folliculitis | 20.67 | 13.24 | 3 | 20196 | 167650 | 110401450 |
| Drug level above therapeutic | 20.54 | 13.24 | 17 | 20182 | 11571 | 110557529 |
| Lymphocyte count increased | 20.43 | 13.24 | 14 | 20185 | 7189 | 110561911 |
| Stomatitis | 20.42 | 13.24 | 12 | 20187 | 270230 | 110298870 |
| Blood alkaline phosphatase increased | 20.37 | 13.24 | 42 | 20157 | 70893 | 110498207 |
| Type 2 diabetes mellitus | 20.03 | 13.24 | 4 | 20195 | 177228 | 110391872 |
| Bile acid malabsorption | 19.52 | 13.24 | 6 | 20193 | 468 | 110568632 |
| Anal incontinence | 19.46 | 13.24 | 22 | 20177 | 21942 | 110547158 |
| Completed suicide | 19.42 | 13.24 | 10 | 20189 | 242371 | 110326729 |
| Fibromyalgia | 19.02 | 13.24 | 4 | 20195 | 170905 | 110398195 |
| Pleural rub | 18.94 | 13.24 | 4 | 20195 | 67 | 110569033 |
| Product odour abnormal | 18.85 | 13.24 | 8 | 20191 | 1575 | 110567525 |
| Transaminases abnormal | 18.79 | 13.24 | 7 | 20192 | 981 | 110568119 |
| Ileal stenosis | 18.78 | 13.24 | 10 | 20189 | 3260 | 110565840 |
| Arthropathy | 18.76 | 13.24 | 15 | 20184 | 287507 | 110281593 |
| Renal neoplasm | 18.62 | 13.24 | 9 | 20190 | 2397 | 110566703 |
| Proctalgia | 18.60 | 13.24 | 17 | 20182 | 13205 | 110555895 |
| Foreign body in throat | 18.29 | 13.24 | 7 | 20192 | 1056 | 110568044 |
| Serum ferritin increased | 18.18 | 13.24 | 16 | 20183 | 11831 | 110557269 |
| Ophthalmoplegia | 18.01 | 13.24 | 10 | 20189 | 3540 | 110565560 |
| Ileus | 17.97 | 13.24 | 25 | 20174 | 30704 | 110538396 |
| Hepatic steatosis | 17.81 | 13.24 | 32 | 20167 | 48799 | 110520301 |
| Renal mass | 17.79 | 13.24 | 10 | 20189 | 3625 | 110565475 |
| Ill-defined disorder | 16.79 | 13.24 | 4 | 20195 | 156849 | 110412251 |
| Drug interaction | 16.78 | 13.24 | 42 | 20157 | 500141 | 110068959 |
| Enteritis | 16.65 | 13.24 | 19 | 20180 | 19137 | 110549963 |
| Plasma cell myeloma | 16.61 | 13.24 | 36 | 20163 | 62900 | 110506200 |
| Bacterial diarrhoea | 16.59 | 13.24 | 5 | 20194 | 365 | 110568735 |
| Fistula | 16.50 | 13.24 | 17 | 20182 | 15282 | 110553818 |
| Intestinal anastomosis complication | 16.17 | 13.24 | 5 | 20194 | 398 | 110568702 |
| Weight decreased | 16.14 | 13.24 | 143 | 20056 | 467914 | 110101186 |
| Drug hypersensitivity | 16.13 | 13.24 | 37 | 20162 | 454053 | 110115047 |
| Glomerular filtration rate decreased | 16.10 | 13.24 | 23 | 20176 | 28933 | 110540167 |
| Impaired healing | 15.93 | 13.24 | 8 | 20191 | 196709 | 110372391 |
| Wheezing | 15.80 | 13.24 | 14 | 20185 | 255216 | 110313884 |
| Myopathy | 15.64 | 13.24 | 21 | 20178 | 24939 | 110544161 |
| Swelling | 15.61 | 13.24 | 25 | 20174 | 351016 | 110218084 |
| Myalgia | 15.57 | 13.24 | 81 | 20118 | 222300 | 110346800 |
| Generalised oedema | 15.08 | 13.24 | 23 | 20176 | 30681 | 110538419 |
| Heart rate decreased | 15.04 | 13.24 | 41 | 20158 | 82715 | 110486385 |
| Sarcoma | 15.04 | 13.24 | 6 | 20193 | 1011 | 110568089 |
| Rectal haemorrhage | 14.91 | 13.24 | 52 | 20147 | 119781 | 110449319 |
| Choking | 14.88 | 13.24 | 16 | 20183 | 15094 | 110554006 |
| Duodenal polyp | 14.87 | 13.24 | 5 | 20194 | 520 | 110568580 |
| Stoma complication | 14.85 | 13.24 | 6 | 20193 | 1045 | 110568055 |
| Hernia | 14.73 | 13.24 | 18 | 20181 | 19482 | 110549618 |
| Hepatic fibrosis | 14.65 | 13.24 | 12 | 20187 | 8054 | 110561046 |
| Infusion site extravasation | 14.52 | 13.24 | 14 | 20185 | 11620 | 110557480 |
| Therapeutic product effect decreased | 14.42 | 13.24 | 14 | 20185 | 244302 | 110324798 |
| Metastasis | 14.39 | 13.24 | 12 | 20187 | 8255 | 110560845 |
| Escherichia urinary tract infection | 14.00 | 13.24 | 16 | 20183 | 16146 | 110552954 |
| Gastroenteritis | 13.61 | 13.24 | 25 | 20174 | 38775 | 110530325 |
| Lung disorder | 13.59 | 13.24 | 8 | 20191 | 180039 | 110389061 |
| Vanishing bile duct syndrome | 13.59 | 13.24 | 8 | 20191 | 3160 | 110565940 |
| Benign vulval neoplasm | 13.52 | 13.24 | 3 | 20196 | 64 | 110569036 |
| Haematochezia | 13.40 | 13.24 | 49 | 20150 | 115475 | 110453625 |
None
| Source | Code | Description |
|---|---|---|
| ATC | C10AC01 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, PLAIN Bile acid sequestrants |
| FDA MoA | N0000175365 | Bile-acid Binding Activity |
| FDA EPC | N0000180292 | Bile Acid Sequestrant |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:35705 | immunosuppressive agent |
| CHEBI has role | CHEBI:35821 | anticholesteremic drug |
| CHEBI has role | CHEBI:50671 | antithyroid drug |
| CHEBI has role | CHEBI:231911 | renoprotective agent |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypercholesterolemia | indication | 13644009 | |
| Hyperlipidemia | indication | 55822004 | DOID:1168 |
| Biliary Obstruction with Pruritus | indication | ||
| Poisoning by digitalis glycoside | off-label use | 12876009 | |
| Chronic diarrhea | off-label use | 236071009 | |
| Classical phenylketonuria | contraindication | 7573000 | |
| Constipation | contraindication | 14760008 | DOID:2089 |
| Hypovolemia | contraindication | 28560003 | |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Hemorrhoids | contraindication | 70153002 | DOID:9746 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Calculus in biliary tract | contraindication | 266474003 | |
| Complete Biliary Obstruction | contraindication |
None
None
None
None
None
None
| ID | Source |
|---|---|
| 4018811 | VUID |
| N0000147114 | NUI |
| D02690 | KEGG_DRUG |
| 2447 | RXNORM |
| CHEBI:749501 | CHEBI |
| CHEMBL1201625 | ChEMBL_ID |
| 1005 | INN_ID |
| DB01432 | DRUGBANK_ID |
| 4B33BGI082 | UNII |
| 4435 | MMSL |
| 6264 | MMSL |
| d00193 | MMSL |
| 001216 | NDDF |
| 387408001 | SNOMEDCT_US |
| 72824008 | SNOMEDCT_US |
| C0008402 | UMLSCUI |
| 4018811 | VANDF |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Prevalite | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0245-0036 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 22 sections |
| CHOLESTYRAMINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24658-266 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 21 sections |
| CHOLESTYRAMINE LIGHT | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24658-270 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 22 sections |
| CHOLESTYRAMINE LIGHT | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24658-271 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 22 sections |
| Cholestyramine | Human Prescription Drug Label | 1 | 27241-134 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 20 sections |
| Cholestyramine | Human Prescription Drug Label | 1 | 33342-293 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 21 sections |
| Cholestyramine | Human Prescription Drug Label | 1 | 33342-293 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 21 sections |
| Cholestyramine | Human Prescription Drug Label | 1 | 33342-319 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 21 sections |
| Cholestyramine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42571-508 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 20 sections |
| CHOLESTYRAMINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42806-265 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 21 sections |
| CHOLESTYRAMINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42806-266 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 21 sections |
| CHOLESTYRAMINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42806-267 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 21 sections |
| CHOLESTYRAMINE LIGHT | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42806-269 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 22 sections |
| CHOLESTYRAMINE LIGHT | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42806-270 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 22 sections |
| CHOLESTYRAMINE LIGHT | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42806-271 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 22 sections |
| Cholestyramine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 49884-465 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 22 sections |
| Cholestyramine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 49884-466 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 22 sections |
| QUESTRAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 49884-936 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 22 sections |
| QUESTRAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 49884-937 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 22 sections |
| Cholestyramine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3415 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 21 sections |
| CHOLESTYRAMINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3845 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 12 sections |
| Cholestyramine Light | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51224-009 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 23 sections |
| Cholestyramine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51224-011 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 21 sections |
| Cholestyramine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4812 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 14 sections |
| Cholestyramine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5526 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 14 sections |
| Cholestyramine for Oral Suspension | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62135-008 | POWDER | 4 g | ORAL | ANDA | 13 sections |
| Cholestyramine for Oral Suspension | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62135-937 | POWDER | 4 g | ORAL | ANDA | 13 sections |
| Cholestyramine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-2162 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 21 sections |
| Cholestyramine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-2164 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 21 sections |
| cholestyramine powder for suspension | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-9196 | POWDER, FOR SUSPENSION | 4 g | ORAL | ANDA | 19 sections |