clotiapine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 717 2058-52-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clothiapine
  • clothiapin
  • clotiapine
  • entumine
  • Molecular weight: 343.87
  • Formula: C18H18ClN3S
  • CLOGP: 4.28
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 18.84
  • ALOGS: -4.38
  • ROTB: 0

Drug dosage:

DoseUnitRoute
80 mg O
80 mg P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 202.19 86.49 57 506 72461 63415998
Sopor 190.55 86.49 43 520 22121 63466338

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sopor 224.40 65.80 53 792 12083 34944003
Drug abuse 124.64 65.80 56 789 99040 34857046
Sudden death 85.50 65.80 26 819 15175 34940911
Toxicity to various agents 80.06 65.80 53 792 200309 34755777

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sopor 393.57 60.96 96 1375 32914 79710003
Drug abuse 304.24 60.96 113 1358 162578 79580339
Toxicity to various agents 106.65 60.96 76 1395 421464 79321453
Intentional self-injury 100.31 60.96 33 1438 32386 79710531
Sudden death 82.20 60.96 26 1445 22485 79720432
Depressed level of consciousness 71.36 60.96 35 1436 96617 79646300
Suicide attempt 61.09 60.96 30 1441 82902 79660015

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AH06 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.59 Basic
pKa2 3.09 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR Ki 9.31 CHEMBL
D(2) dopamine receptor GPCR Ki 8.36 CHEMBL
D(1A) dopamine receptor GPCR Ki 7.85 CHEMBL
Muscarinic acetylcholine receptor GPCR Ki 6.87 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 9.23 CHEMBL

External reference:

IDSource
D01597 KEGG_DRUG
2620 RXNORM
C0009071 UMLSCUI
CHEBI:31424 CHEBI
CHEMBL304902 ChEMBL_ID
DB13256 DRUGBANK_ID
C084602 MESH_SUPPLEMENTAL_RECORD_UI
16351 PUBCHEM_CID
006953 NDDF
698028004 SNOMEDCT_US
2136 INN_ID
Z05HCY0X1T UNII

Pharmaceutical products:

None