clopidogrel 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
platelet aggregation inhibitors 708 113665-84-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clopidogrel
  • zyllt
  • clopidogrel bisulfate
  • clopidogrel besilate
  • clopidogrel hydrochloride
  • clopidogrel hydrogen sulphate
  • clopidogrel hydrobromide
  • clopidogrel sulfate
  • clopidogrel HCl
A ticlopidine analog and platelet purinergic P2Y receptor antagonist that inhibits adenosine diphosphate-mediated PLATELET AGGREGATION. It is used to prevent THROMBOEMBOLISM in patients with ARTERIAL OCCLUSIVE DISEASES; MYOCARDIAL INFARCTION; STROKE; or ATRIAL FIBRILLATION.
  • Molecular weight: 321.82
  • Formula: C16H16ClNO2S
  • CLOGP: 4.21
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 29.54
  • ALOGS: -4.43
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
75 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Bocci G, Oprea TI, Benet LZ
MRTD (Maximum Recommended Therapeutic Daily Dose) 13.32 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.01 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 23.65 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.06 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 15, 1998 EMA
Nov. 17, 1997 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 2224.54 9.94 1905 156773 97988 63232356
Acute myocardial infarction 1193.13 9.94 831 157847 31293 63299051
Gastrointestinal haemorrhage 1191.04 9.94 1229 157449 79947 63250397
Cerebrovascular accident 934.08 9.94 1247 157431 106777 63223567
Coronary artery disease 870.92 9.94 690 157988 31687 63298657
Anaemia 624.49 9.94 1877 156801 291553 63038791
Drug ineffective 554.52 9.94 1115 157563 1043650 62286694
Melaena 524.79 9.94 503 158175 29862 63300482
Labelled drug-drug interaction medication error 521.68 9.94 357 158321 13042 63317302
Coronary arterial stent insertion 468.99 9.94 198 158480 2631 63327713
Haematoma 460.02 9.94 499 158179 34321 63296023
Cardiac failure congestive 458.54 9.94 826 157852 91607 63238737
Angina pectoris 450.71 9.94 461 158217 29617 63300727
Synovitis 423.28 9.94 9 158669 186909 63143435
Systemic lupus erythematosus 401.56 9.94 32 158646 208886 63121458
Drug interaction 400.56 9.94 1371 157307 227760 63102584
Pemphigus 400.48 9.94 13 158665 183713 63146631
Transient ischaemic attack 384.29 9.94 473 158205 37280 63293064
Cerebral haemorrhage 375.88 9.94 423 158255 30306 63300038
Drug intolerance 368.89 9.94 155 158523 308506 63021838
Maternal exposure during pregnancy 364.56 9.94 57 158621 220005 63110339
Hand deformity 363.72 9.94 7 158671 159450 63170894
Treatment failure 349.84 9.94 43 158635 199000 63131344
Coronary artery occlusion 334.94 9.94 225 158453 7966 63322378
Haematemesis 317.56 9.94 386 158292 30026 63300318
Vascular stent thrombosis 315.14 9.94 111 158567 866 63329478
Rectal haemorrhage 309.32 9.94 488 158190 48542 63281802
Infusion related reaction 308.54 9.94 114 158564 245407 63084937
Subdural haematoma 299.37 9.94 264 158414 14064 63316280
Alopecia 299.30 9.94 243 158435 337293 62993051
Glossodynia 299.25 9.94 45 158633 178831 63151513
Acute kidney injury 295.40 9.94 1372 157306 262043 63068301
Therapeutic product effect decreased 294.13 9.94 62 158616 193125 63137219
Joint swelling 292.89 9.94 234 158444 327432 63002912
Haematochezia 290.66 9.94 498 158180 53046 63277298
Upper gastrointestinal haemorrhage 289.78 9.94 293 158385 18559 63311785
Contraindicated product administered 283.83 9.94 95 158583 217553 63112791
Off label use 283.74 9.94 811 157867 673651 62656693
Acute coronary syndrome 276.86 9.94 218 158460 9908 63320436
Rhabdomyolysis 273.85 9.94 435 158243 43516 63286828
Haemorrhage 270.76 9.94 520 158158 60502 63269842
Arthropathy 263.06 9.94 129 158549 234663 63095681
Pericarditis 258.87 9.94 18 158660 131561 63198783
Angina unstable 257.30 9.94 181 158497 6914 63323430
Shock haemorrhagic 244.98 9.94 201 158477 9694 63320650
Thrombosis in device 240.30 9.94 127 158551 2863 63327481
Epistaxis 238.95 9.94 548 158130 72177 63258167
Haemorrhage intracranial 236.92 9.94 225 158453 13194 63317150
Rheumatoid arthritis 235.96 9.94 174 158504 253645 63076699
Vascular pseudoaneurysm 229.99 9.94 100 158578 1434 63328910
Chest pain 226.05 9.94 1103 157575 214856 63115488
Coronary artery stenosis 222.49 9.94 142 158536 4602 63325742
Product use issue 218.46 9.94 141 158537 220379 63109965
Stent placement 215.89 9.94 128 158550 3627 63326717
Pain 204.93 9.94 1055 157623 739573 62590771
Abdominal discomfort 196.19 9.94 312 158366 320573 63009771
Rheumatoid factor positive 195.33 9.94 3 158675 84403 63245941
Fall 192.23 9.94 1653 157025 390681 62939663
Discomfort 190.38 9.94 90 158588 167284 63163060
Duodenal ulcer perforation 183.66 9.94 8 158670 87201 63243143
Exposure during pregnancy 182.59 9.94 80 158598 155467 63174877
Hepatic enzyme increased 181.22 9.94 144 158534 202184 63128160
Vascular stent stenosis 179.02 9.94 63 158615 490 63329854
Helicobacter infection 173.27 9.94 16 158662 92769 63237575
Infection 172.47 9.94 191 158487 228982 63101362
Hypersensitivity 171.04 9.94 293 158385 292392 63037952
Wound 170.56 9.94 98 158580 163165 63167179
Swelling 168.04 9.94 268 158410 275110 63055234
Hyperkalaemia 162.32 9.94 394 158284 53809 63276535
Cerebral infarction 162.10 9.94 246 158432 23647 63306697
Eosinophilic bronchitis 161.83 9.94 59 158619 514 63329830
Hypoglycaemia 160.40 9.94 418 158260 59647 63270697
Folliculitis 156.71 9.94 4 158674 70313 63260031
Syncope 156.10 9.94 644 158034 116741 63213603
Arthralgia 148.67 9.94 827 157851 568883 62761461
Coronary artery thrombosis 147.48 9.94 67 158611 1072 63329272
Lower gastrointestinal haemorrhage 146.39 9.94 136 158542 7754 63322590
Rash 145.89 9.94 815 157863 560056 62770288
Hypotension 145.82 9.94 1172 157506 271432 63058912
Haemoglobin decreased 142.82 9.94 730 157948 144755 63185589
Thrombotic thrombocytopenic purpura 141.75 9.94 99 158579 3737 63326607
Ecchymosis 141.26 9.94 156 158522 10938 63319406
Multiple injuries 140.62 9.94 75 158603 1723 63328621
Retroperitoneal haemorrhage 139.37 9.94 87 158591 2710 63327634
Spinal epidural haematoma 138.72 9.94 64 158614 1063 63329281
Therapeutic product effect incomplete 138.00 9.94 70 158608 124986 63205358
Arterial haemorrhage 135.35 9.94 72 158606 1645 63328699
Muscle injury 134.35 9.94 7 158671 65338 63265006
Sinusitis 130.43 9.94 229 158449 226424 63103920
Pyrexia 130.38 9.94 669 158009 469809 62860535
Psoriatic arthropathy 130.04 9.94 34 158644 91486 63238858
Abdominal wall haematoma 129.91 9.94 86 158592 2969 63327375
Nasopharyngitis 128.04 9.94 278 158400 253979 63076365
Hyponatraemia 127.44 9.94 586 158092 111314 63219030
Intentional product use issue 122.23 9.94 85 158593 127807 63202537
Arteriosclerosis 120.39 9.94 137 158541 9929 63320415
Hemiparesis 119.07 9.94 211 158467 23071 63307273
Musculoskeletal stiffness 118.96 9.94 173 158505 184445 63145899
Completed suicide 117.90 9.94 114 158564 145559 63184785
Subarachnoid haemorrhage 117.27 9.94 161 158517 14122 63316222
Ischaemic stroke 116.34 9.94 181 158497 17776 63312568
Toxicity to various agents 115.87 9.94 281 158397 246969 63083375
Myocardial ischaemia 111.73 9.94 149 158529 12710 63317634
Irritable bowel syndrome 110.82 9.94 34 158644 82378 63247966
Drug hypersensitivity 109.63 9.94 403 158275 310284 63020060
Blood loss anaemia 105.10 9.94 121 158557 8880 63321464
Carotid artery stenosis 101.53 9.94 92 158586 5078 63325266
Extradural haematoma 99.78 9.94 59 158619 1663 63328681
Cardiogenic shock 98.86 9.94 168 158510 17764 63312580
Febrile neutropenia 97.83 9.94 91 158587 118358 63211986
Fatigue 97.40 9.94 1599 157079 886429 62443915
Cardiac disorder 97.34 9.94 314 158364 50502 63279842
Bradycardia 96.71 9.94 401 158277 72826 63257518
Coronary artery bypass 96.67 9.94 65 158613 2304 63328040
Haemoptysis 94.88 9.94 217 158461 28509 63301835
Renal failure 91.81 9.94 555 158123 117097 63213247
Abortion spontaneous 88.47 9.94 8 158670 47187 63283157
Product use in unapproved indication 88.29 9.94 198 158480 178882 63151462
Post procedural haematoma 87.75 9.94 49 158629 1236 63329108
Ischaemic cardiomyopathy 87.05 9.94 62 158616 2415 63327929
C-reactive protein abnormal 85.91 9.94 8 158670 46088 63284256
Lactic acidosis 85.85 9.94 250 158428 38037 63292307
Peripheral arterial occlusive disease 84.95 9.94 76 158602 4125 63326219
Asthenia 83.03 9.94 1383 157295 382221 62948123
Hip arthroplasty 81.92 9.94 11 158667 47635 63282709
Drug abuse 80.87 9.94 40 158638 72478 63257866
Gastrointestinal disorder 80.63 9.94 127 158551 131112 63199232
Peripheral vascular disorder 80.55 9.94 87 158591 5948 63324396
Atrial fibrillation 79.73 9.94 532 158146 116104 63214240
Cardiac failure 77.00 9.94 432 158246 88710 63241634
Pallor 76.78 9.94 208 158470 30360 63299984
Arterial occlusive disease 74.51 9.94 83 158595 5875 63324469
Ill-defined disorder 73.36 9.94 58 158620 81697 63248647
Cerebral haematoma 73.23 9.94 66 158612 3617 63326727
Haemorrhagic stroke 72.97 9.94 81 158597 5711 63324633
Stomatitis 72.85 9.94 148 158530 138577 63191767
Impaired healing 72.19 9.94 90 158588 102452 63227892
Intraventricular haemorrhage 72.06 9.94 52 158626 2068 63328276
Malignant neoplasm progression 71.52 9.94 60 158618 82061 63248283
Weight increased 70.85 9.94 373 158305 260419 63069925
Intestinal haemorrhage 70.76 9.94 66 158612 3781 63326563
Haematuria 69.86 9.94 195 158483 28962 63301382
Pregnancy 69.70 9.94 6 158672 36830 63293514
Retroperitoneal haematoma 69.65 9.94 58 158620 2855 63327489
Loss of personal independence in daily activities 67.85 9.94 86 158592 97204 63233140
Arterial stenosis 67.49 9.94 32 158646 567 63329777
Coronary artery restenosis 67.42 9.94 28 158650 356 63329988
Gastritis erosive 66.87 9.94 79 158599 5960 63324384
Diverticulum intestinal haemorrhagic 66.51 9.94 44 158634 1517 63328827
Blood creatine phosphokinase increased 65.65 9.94 196 158482 30234 63300110
Device expulsion 65.24 9.94 6 158672 34916 63295428
Knee arthroplasty 64.96 9.94 27 158651 54179 63276165
Neutrophilia 63.21 9.94 66 158612 4340 63326004
Disease progression 62.73 9.94 133 158545 122625 63207719
Arteriosclerosis coronary artery 62.23 9.94 90 158588 8283 63322061
Skin candida 61.82 9.94 43 158635 1612 63328732
Mitral valve incompetence 61.40 9.94 145 158533 19449 63310895
Post procedural haemorrhage 61.24 9.94 87 158591 7877 63322467
International normalised ratio increased 60.31 9.94 253 158425 46172 63284172
Duodenal ulcer 60.04 9.94 85 158593 7671 63322673
Internal haemorrhage 59.58 9.94 69 158609 5096 63325248
Procedural haemorrhage 59.10 9.94 51 158627 2637 63327707
Product administration error 58.87 9.94 155 158523 22242 63308102
Splenic rupture 57.70 9.94 38 158640 1300 63329044
Condition aggravated 57.45 9.94 686 157992 401531 62928813
Cardiovascular disorder 56.50 9.94 104 158574 11708 63318636
Brain herniation 56.22 9.94 57 158621 3620 63326724
Peripheral ischaemia 55.99 9.94 65 158613 4813 63325531
Injection site reaction 55.75 9.94 39 158639 58485 63271859
Tachyarrhythmia 55.66 9.94 62 158616 4388 63325956
Spontaneous haematoma 55.45 9.94 32 158646 861 63329483
Dysarthria 54.89 9.94 232 158446 42479 63287865
Traumatic haematoma 54.11 9.94 38 158640 1447 63328897
Angioplasty 53.96 9.94 37 158641 1355 63328989
Ventricular fibrillation 53.67 9.94 102 158576 11765 63318579
Abnormal loss of weight 53.33 9.94 69 158609 5713 63324631
Intentional overdose 53.33 9.94 64 158614 74088 63256256
Lower respiratory tract infection 53.17 9.94 162 158516 132145 63198199
Polyp 52.77 9.94 73 158605 6448 63323896
Ocular retrobulbar haemorrhage 52.50 9.94 17 158661 99 63330245
Peripheral artery stenosis 52.21 9.94 27 158651 581 63329763
Peripheral swelling 52.06 9.94 420 158258 265522 63064822
Oesophageal intramural haematoma 51.28 9.94 16 158662 81 63330263
Coronary artery dissection 51.17 9.94 30 158648 832 63329512
Aortic arteriosclerosis 50.98 9.94 70 158608 6139 63324205
Eosinophil count increased 50.75 9.94 95 158583 10833 63319511
Subdural haemorrhage 50.74 9.94 50 158628 3068 63327276
Loss of consciousness 50.61 9.94 484 158194 117637 63212707
Cardiac tamponade 50.46 9.94 61 158617 4714 63325630
Chronic obstructive pulmonary disease 50.33 9.94 298 158380 62388 63267956
Haemarthrosis 50.16 9.94 50 158628 3111 63327233
Blister 50.02 9.94 162 158516 129652 63200692
Liver injury 49.36 9.94 47 158631 60473 63269871
Gastric haemorrhage 49.36 9.94 70 158608 6328 63324016
Cerebellar haemorrhage 49.24 9.94 35 158643 1359 63328985
Foetal exposure during pregnancy 49.12 9.94 10 158668 31952 63298392
Intermittent claudication 49.00 9.94 39 158639 1800 63328544
Live birth 48.97 9.94 4 158674 25626 63304718
Dyspnoea 48.35 9.94 2066 156612 659247 62671097
Coma scale abnormal 48.32 9.94 62 158616 5091 63325253
Gastritis 48.23 9.94 203 158475 37100 63293244
Presyncope 48.14 9.94 166 158512 27619 63302725
Cerebral ischaemia 48.09 9.94 71 158607 6657 63323687
Injection site erythema 47.81 9.94 84 158594 83090 63247254
Dizziness 47.73 9.94 1409 157269 428516 62901828
Vascular graft 46.67 9.94 28 158650 811 63329533
Atrioventricular block 46.66 9.94 75 158603 7572 63322772
Faeces discoloured 46.53 9.94 126 158552 18383 63311961
Fibromyalgia 46.42 9.94 81 158597 80339 63250005
Kidney rupture 46.28 9.94 13 158665 42 63330302
Pemphigoid 46.15 9.94 73 158605 7271 63323073
White blood cell count decreased 46.03 9.94 185 158493 138919 63191425
Cardiac arrest 45.13 9.94 390 158288 92155 63238189
Pulmonary alveolar haemorrhage 45.09 9.94 57 158621 4611 63325733
Microcytic anaemia 45.01 9.94 49 158629 3380 63326964
Electrocardiogram ST segment elevation 44.52 9.94 52 158626 3875 63326469
Device occlusion 44.46 9.94 72 158606 7315 63323029
Gastric ulcer haemorrhage 44.38 9.94 58 158620 4850 63325494
Heparin-induced thrombocytopenia 44.34 9.94 56 158622 4526 63325818
Subarachnoid haematoma 44.09 9.94 10 158668 8 63330336
Gastrointestinal tract mucosal pigmentation 43.98 9.94 24 158654 578 63329766
Ischaemic cerebral infarction 43.45 9.94 32 158646 1314 63329030
Muscle haemorrhage 42.73 9.94 46 158632 3133 63327211
Oedema peripheral 42.64 9.94 688 157990 188823 63141521
Headache 41.97 9.94 1234 157444 632007 62698337
Myalgia 41.65 9.94 554 158124 145975 63184369
Chronic kidney disease 41.18 9.94 223 158455 45175 63285169
Gastric ulcer 41.11 9.94 143 158535 23894 63306450
Head injury 40.95 9.94 156 158522 27240 63303104
Pericardial haemorrhage 40.31 9.94 33 158645 1586 63328758
Oesophageal pain 40.29 9.94 48 158630 3653 63326691
Oesophageal spasm 39.90 9.94 44 158634 3079 63327265
Therapy non-responder 39.81 9.94 81 158597 75820 63254524
Carotid arteriosclerosis 39.60 9.94 28 158650 1078 63329266
Dermatitis exfoliative 39.59 9.94 58 158620 5401 63324943
Intentional self-injury 39.55 9.94 8 158670 25679 63304665
Petechiae 39.44 9.94 99 158579 13798 63316546
Angioedema 39.13 9.94 229 158449 47736 63282608
Circulatory collapse 38.82 9.94 132 158546 21806 63308538
Coronary angioplasty 38.49 9.94 13 158665 88 63330256
Diverticulum intestinal 38.47 9.94 64 158614 6649 63323695
Migraine 38.41 9.94 131 158547 103215 63227129
Lacunar infarction 38.14 9.94 44 158634 3236 63327108
Adverse event 37.25 9.94 70 158608 67489 63262855
Labile hypertension 37.24 9.94 20 158658 466 63329878
C-reactive protein increased 36.60 9.94 118 158560 94589 63235755
Tricuspid valve incompetence 36.22 9.94 99 158579 14522 63315822
Intracardiac thrombus 36.19 9.94 37 158641 2373 63327971
Adverse drug reaction 36.18 9.94 92 158586 79622 63250722
Groin pain 35.84 9.94 79 158599 10124 63320220
COVID-19 35.81 9.94 153 158525 112950 63217394
Endothelial dysfunction 35.76 9.94 14 158664 151 63330193
Hallucination 35.62 9.94 247 158431 54570 63275774
Pulmonary oedema 35.51 9.94 247 158431 54626 63275718
Facial paralysis 34.71 9.94 95 158583 13946 63316398
Toxic skin eruption 34.71 9.94 90 158588 12795 63317549
Hypomagnesaemia 34.55 9.94 153 158525 28584 63301760
Haemangioma of spleen 34.17 9.94 9 158669 21 63330323
Renal artery stenosis 33.67 9.94 32 158646 1877 63328467
Puncture site haemorrhage 33.57 9.94 16 158662 287 63330057
Peripheral artery occlusion 33.46 9.94 27 158651 1271 63329073
Lymphocyte count decreased 33.26 9.94 17 158661 30240 63300104
Diabetes mellitus inadequate control 33.17 9.94 98 158580 15028 63315316
Lymphatic fistula 33.11 9.94 22 158656 764 63329580
Arthritis 33.02 9.94 163 158515 115758 63214586
Mobility decreased 33.02 9.94 173 158505 120986 63209358
Periorbital haematoma 32.91 9.94 22 158656 772 63329572
Blood glucose increased 32.85 9.94 337 158341 83419 63246925
Injection site pain 32.82 9.94 190 158488 129610 63200734
Large intestinal haemorrhage 32.46 9.94 27 158651 1327 63329017
Liver function test increased 32.41 9.94 21 158657 32790 63297554
Acute pulmonary oedema 31.92 9.94 66 158612 8092 63322252
Femoral hernia incarcerated 31.76 9.94 22 158656 819 63329525
Renal impairment 31.61 9.94 349 158329 88006 63242338
Gastrointestinal vascular malformation haemorrhagic 31.57 9.94 14 158664 211 63330133
Cholestasis 31.17 9.94 151 158527 29283 63301061
Therapeutic response decreased 31.13 9.94 67 158611 61458 63268886
Coronary artery reocclusion 30.96 9.94 9 158669 34 63330310
Product prescribing error 30.88 9.94 139 158539 26150 63304194
Acute left ventricular failure 30.77 9.94 24 158654 1075 63329269
Suicidal ideation 30.74 9.94 69 158609 62352 63267992
Acne 30.61 9.94 10 158668 23283 63307061
Red blood cell sedimentation rate increased 30.53 9.94 39 158639 43943 63286401
Drug tolerance decreased 30.11 9.94 4 158674 17469 63312875
Thrombosis 30.07 9.94 270 158408 64485 63265859
Hiatus hernia 29.87 9.94 120 158558 21474 63308870
Haemorrhage subcutaneous 29.73 9.94 37 158641 2946 63327398
Aortic aneurysm 29.57 9.94 42 158636 3802 63326542
Sedation 29.52 9.94 32 158646 38777 63291567
Ejection fraction decreased 29.23 9.94 122 158556 22210 63308134
Hemiplegia 29.22 9.94 69 158609 9254 63321090
Aphasia 29.19 9.94 161 158517 32839 63297505
Atrioventricular block complete 29.11 9.94 64 158614 8187 63322157
Bladder sphincter atony 28.86 9.94 12 158666 153 63330191
Systemic infection 28.84 9.94 46 158632 4614 63325730
Type 2 diabetes mellitus 28.76 9.94 74 158604 63794 63266550
Inflammation 28.76 9.94 107 158571 82166 63248178
Capillary fragility test 28.68 9.94 8 158670 25 63330319
Blood cholesterol increased 28.67 9.94 129 158549 93903 63236441
Suicide attempt 28.67 9.94 69 158609 60849 63269495
Pancreatic steatosis 28.04 9.94 22 158656 994 63329350
Low density lipoprotein increased 27.96 9.94 54 158624 6303 63324041
Cerebral mass effect 27.89 9.94 21 158657 892 63329452
Eye haemorrhage 27.85 9.94 64 158614 8432 63321912
Coronary artery perforation 27.78 9.94 8 158670 29 63330315
Platelet function test abnormal 27.75 9.94 10 158668 84 63330260
Bursitis 27.67 9.94 31 158647 37010 63293334
Iron deficiency anaemia 27.65 9.94 111 158567 19858 63310486
Catheter site haematoma 27.60 9.94 12 158666 172 63330172
Duplicate therapy error 27.34 9.94 10 158668 88 63330256
Percutaneous coronary intervention 27.13 9.94 13 158665 236 63330108
Hypertensive heart disease 27.02 9.94 32 158646 2420 63327924
Red blood cell sedimentation rate abnormal 26.88 9.94 8 158670 19774 63310570
Duodenal ulcer haemorrhage 26.86 9.94 32 158646 2435 63327909
Cardiac operation 26.80 9.94 37 158641 3261 63327083
Wound infection pseudomonas 26.80 9.94 24 158654 1304 63329040
Aortic valve stenosis 26.80 9.94 37 158641 3262 63327082
Dehydration 26.77 9.94 594 158084 172760 63157584
Hepatic cyst 26.72 9.94 47 158631 5107 63325237
Hepatotoxicity 26.59 9.94 32 158646 37009 63293335
Traumatic intracranial haemorrhage 26.22 9.94 16 158662 478 63329866
Orthopnoea 26.10 9.94 52 158626 6209 63324135
Foot deformity 25.95 9.94 19 158659 27834 63302510
Insulin autoimmune syndrome 25.87 9.94 10 158668 104 63330240
Rectosigmoid cancer 25.86 9.94 11 158667 149 63330195
Hepatorenal failure 25.85 9.94 18 158660 676 63329668
Orbital compartment syndrome 25.69 9.94 9 158669 69 63330275
Cerebral hyperperfusion syndrome 25.56 9.94 7 158671 20 63330324
Premature baby 25.38 9.94 10 158668 20725 63309619
Device inappropriate shock delivery 25.34 9.94 6 158672 7 63330337
Nephrosclerosis 25.23 9.94 21 158657 1033 63329311
Multiple sclerosis relapse 25.19 9.94 52 158626 48426 63281918
Arterial thrombosis 25.10 9.94 24 158654 1419 63328925
Myelosuppression 25.05 9.94 14 158664 23689 63306655
Coagulation time prolonged 25.03 9.94 24 158654 1424 63328920
Psoriasis 24.92 9.94 122 158556 86835 63243509
Dysphagia 24.77 9.94 334 158344 88251 63242093
Crush syndrome 24.67 9.94 10 158668 119 63330225
Coagulopathy 24.41 9.94 109 158569 20435 63309909
Urine output decreased 24.30 9.94 73 158605 11297 63319047
Haemorrhagic transformation stroke 24.30 9.94 22 158656 1213 63329131
Cerebrovascular disorder 24.26 9.94 32 158646 2700 63327644
Blood pressure decreased 24.26 9.94 259 158419 64763 63265581
Sleep disorder 24.21 9.94 113 158565 81453 63248891
Ischaemia 24.07 9.94 43 158635 4729 63325615
Cardiac procedure complication 24.04 9.94 11 158667 179 63330165
Cardiac death 23.65 9.94 16 158662 573 63329771
Postinfarction angina 23.57 9.94 7 158671 29 63330315
Left ventricular failure 23.43 9.94 47 158631 5640 63324704
Spinal subdural haematoma 23.41 9.94 10 158668 137 63330207
Product odour abnormal 23.39 9.94 22 158656 1274 63329070
Hyperlipidaemia 23.37 9.94 104 158574 19467 63310877
Pharyngeal haematoma 23.34 9.94 8 158670 57 63330287
Swollen tongue 23.31 9.94 158 158520 34642 63295702
Carotid artery occlusion 23.30 9.94 42 158636 4652 63325692
Acid base balance abnormal 23.26 9.94 12 158666 257 63330087
Haemothorax 23.23 9.94 28 158650 2157 63328187
Mitral valve stenosis 23.22 9.94 21 158657 1156 63329188
Rheumatoid nodule 23.19 9.94 7 158671 17148 63313196
Amblyopia 23.17 9.94 12 158666 259 63330085
Osteoporosis 23.17 9.94 70 158608 57268 63273076
Contusion 23.12 9.94 514 158164 149530 63180814
Multiple organ dysfunction syndrome 23.04 9.94 230 158448 56522 63273822
Joint effusion 22.99 9.94 7 158671 17053 63313291
Immunodeficiency 22.84 9.94 11 158667 20243 63310101
Tongue oedema 22.72 9.94 41 158637 4545 63325799
Haemoperitoneum 22.65 9.94 31 158647 2710 63327634
Blood creatine phosphokinase MB increased 22.63 9.94 21 158657 1195 63329149
Small intestinal haemorrhage 22.56 9.94 27 158651 2065 63328279
Cardiac stress test abnormal 22.51 9.94 16 158662 621 63329723
Obstructive airways disorder 22.50 9.94 107 158571 20592 63309752
Neutropenia 22.49 9.94 305 158373 174700 63155644
Occult blood positive 22.40 9.94 36 158642 3634 63326710
Grip strength decreased 22.37 9.94 14 158664 22273 63308071
Herpes zoster 22.32 9.94 118 158560 82344 63248000
Skin weeping 22.30 9.94 17 158661 736 63329608
Dilatation ventricular 22.27 9.94 29 158649 2416 63327928
Respiratory tract haemorrhage 22.26 9.94 14 158664 442 63329902
Oesophageal mucosal dissection 22.21 9.94 6 158672 16 63330328
Pulmonary fibrosis 22.16 9.94 41 158637 39768 63290576
Dyspnoea exertional 21.94 9.94 239 158439 60063 63270281
Resuscitation 21.76 9.94 20 158658 1124 63329220
Spinal cord compression 21.73 9.94 38 158640 4110 63326234
Joint stiffness 21.68 9.94 45 158633 41824 63288520
Pericardial effusion 21.67 9.94 139 158539 29919 63300425
Neoplasm progression 21.65 9.94 36 158642 36392 63293952
Troponin increased 21.65 9.94 65 158613 10056 63320288
Embolic stroke 21.64 9.94 36 158642 3740 63326604
Ventricular tachycardia 21.52 9.94 103 158575 19876 63310468
Lip dry 21.49 9.94 6 158672 15464 63314880
Spinal cord haemorrhage 21.43 9.94 11 158667 233 63330111
Product substitution issue 21.42 9.94 88 158590 15908 63314436
Catheterisation cardiac 21.35 9.94 40 158638 4563 63325781
Eructation 21.22 9.94 57 158621 8276 63322068
Unresponsive to stimuli 21.16 9.94 151 158527 33665 63296679
Blood glucose decreased 21.13 9.94 106 158572 20846 63309498
Neurotoxicity 21.11 9.94 8 158670 16982 63313362
Spontaneous haemorrhage 21.07 9.94 15 158663 584 63329760
Diabetic macroangiopathy 21.02 9.94 9 158669 124 63330220
Iliac artery occlusion 21.00 9.94 10 158668 179 63330165
Contrast encephalopathy 20.97 9.94 8 158670 80 63330264
Cytokine release syndrome 20.94 9.94 5 158673 14309 63316035
Hydrocephalus 20.88 9.94 43 158635 5257 63325087
Haemorrhoidal haemorrhage 20.88 9.94 38 158640 4241 63326103
Cachexia 20.87 9.94 45 158633 5681 63324663
Premature delivery 20.86 9.94 27 158651 30254 63300090
Peripheral artery thrombosis 20.79 9.94 25 158653 1921 63328423
Bundle branch block left 20.78 9.94 51 158627 7008 63323336
Injection site swelling 20.75 9.94 56 158622 47516 63282828
Vessel puncture site haematoma 20.64 9.94 9 158669 130 63330214
Haemodynamic instability 20.59 9.94 60 158618 9130 63321214
Tongue haemorrhage 20.51 9.94 13 158665 416 63329928
Hypokalaemia 20.47 9.94 369 158309 103435 63226909
Administration site discomfort 20.46 9.94 8 158670 86 63330258
Lichen nitidus 20.46 9.94 8 158670 86 63330258
Sodium retention 20.45 9.94 9 158669 133 63330211
Nephrogenic systemic fibrosis 20.40 9.94 39 158639 4517 63325827
Jaundice 20.31 9.94 134 158544 29117 63301227
Night sweats 20.15 9.94 59 158619 48755 63281589
Angiopathy 20.06 9.94 39 158639 4574 63325770
Electrocardiogram ST segment depression 20.05 9.94 30 158648 2847 63327497
Metastases to bone 20.02 9.94 14 158664 21005 63309339
Vascular stenosis 19.99 9.94 12 158666 348 63329996
Sciatic nerve palsy 19.99 9.94 6 158672 26 63330318
Soft tissue haemorrhage 19.86 9.94 11 158667 273 63330071
Pulseless electrical activity 19.71 9.94 52 158626 7469 63322875
Arterial stent insertion 19.63 9.94 6 158672 28 63330316
Hypoglycaemic coma 19.61 9.94 28 158650 2547 63327797
Caesarean section 19.59 9.94 9 158669 17023 63313321
Brain stem stroke 19.48 9.94 12 158666 365 63329979
Bleeding time prolonged 19.44 9.94 15 158663 661 63329683
Facial nerve disorder 19.44 9.94 14 158664 555 63329789
Vertigo 19.38 9.94 232 158446 59655 63270689
Drop attacks 19.33 9.94 15 158663 667 63329677
Hyperparathyroidism secondary 19.32 9.94 21 158657 1446 63328898
Coagulation factor increased 19.18 9.94 5 158673 11 63330333
Disability 19.16 9.94 11 158667 18336 63312008
Gastrointestinal angiodysplasia 19.15 9.94 13 158665 468 63329876
Sensorimotor disorder 19.03 9.94 13 158665 473 63329871
Premature labour 19.03 9.94 4 158674 12500 63317844
Duodenitis 19.02 9.94 34 158644 3741 63326603
Carotid artery disease 18.97 9.94 22 158656 1627 63328717
Anal haemorrhage 18.94 9.94 25 158653 2111 63328233
Flushing 18.92 9.94 110 158568 74977 63255367
Mouth haemorrhage 18.91 9.94 48 158630 6735 63323609
Faecaloma 18.91 9.94 53 158625 7888 63322456
Insomnia 18.91 9.94 402 158276 214850 63115494
Muscle spasticity 18.87 9.94 16 158662 21778 63308566
Deep vein thrombosis postoperative 18.67 9.94 3 158675 11366 63318978
Therapeutic response increased 18.61 9.94 12 158666 396 63329948
Lethargy 18.57 9.94 218 158460 55789 63274555
Brain compression 18.55 9.94 12 158666 398 63329946
Ear pain 18.55 9.94 39 158639 36079 63294265
Ocular icterus 18.52 9.94 33 158645 3623 63326721
Neuropathy peripheral 18.50 9.94 188 158490 113479 63216865
Aortic dissection 18.48 9.94 24 158654 1994 63328350
Embolism arterial 18.48 9.94 17 158661 957 63329387
Sinus node dysfunction 18.45 9.94 38 158640 4647 63325697
Respiratory rate increased 18.21 9.94 75 158603 13573 63316771
Ear infection 18.20 9.94 43 158635 38170 63292174
Inappropriate schedule of product administration 18.17 9.94 169 158509 103796 63226548
Kounis syndrome 18.12 9.94 22 158656 1708 63328636
Lipoprotein (a) increased 18.11 9.94 6 158672 38 63330306
Tenosynovitis 17.99 9.94 6 158672 13789 63316555
Erosive oesophagitis 17.91 9.94 22 158656 1728 63328616
Arterial restenosis 17.84 9.94 5 158673 16 63330328
Catheter site haemorrhage 17.83 9.94 30 158648 3145 63327199
Vessel perforation 17.75 9.94 4 158674 3 63330341
Basal ganglia haemorrhage 17.70 9.94 14 158664 640 63329704
Diverticulum 17.69 9.94 68 158610 11923 63318421
Coronary ostial stenosis 17.68 9.94 7 158671 78 63330266
Mucosal membrane hyperplasia 17.59 9.94 6 158672 42 63330302
Injection site pruritus 17.57 9.94 56 158622 45060 63285284
Disorientation 17.55 9.94 163 158515 39289 63291055
Tongue haematoma 17.52 9.94 7 158671 80 63330264
Cytomegalovirus infection 17.40 9.94 16 158662 20936 63309408
Ventricular hypertrophy 17.38 9.94 31 158647 3405 63326939
Oesophagitis 17.36 9.94 79 158599 14929 63315415
Vaginal haematoma 17.22 9.94 8 158670 135 63330209
Anal prolapse 17.07 9.94 7 158671 86 63330258
Arterial injury 17.00 9.94 10 158668 279 63330065
Autoimmune disorder 16.96 9.94 11 158667 17166 63313178
Change of bowel habit 16.93 9.94 24 158654 2169 63328175
Eyelid retraction 16.90 9.94 6 158672 48 63330296
Cerebral artery thrombosis 16.89 9.94 11 158667 369 63329975
Renal injury 16.88 9.94 57 158621 9382 63320962
Non-small cell lung cancer recurrent 16.85 9.94 7 158671 89 63330255
Vascular occlusion 16.80 9.94 16 158662 941 63329403
Fear 16.78 9.94 81 158597 15685 63314659
Oropharyngeal pain 16.77 9.94 153 158525 94334 63236010
Upper respiratory tract infection 16.76 9.94 128 158550 81919 63248425
Arrhythmia 16.67 9.94 157 158521 37983 63292361
Product dose omission issue 16.61 9.94 452 158226 233861 63096483
Obesity 16.54 9.94 31 158647 29921 63300423
Angiocardiogram 16.48 9.94 6 158672 52 63330292
Sinus bradycardia 16.39 9.94 76 158602 14475 63315869
Hot flush 16.31 9.94 69 158609 51090 63279254
Impaired quality of life 16.30 9.94 7 158671 13776 63316568
Left ventricular hypertrophy 16.29 9.94 39 158639 5276 63325068
Eosinophilia 16.26 9.94 105 158573 22651 63307693
Infarction 16.25 9.94 26 158652 2615 63327729
Foot amputation 16.23 9.94 10 158668 304 63330040
Wrong patient 16.22 9.94 9 158669 224 63330120
Lymphoedema 16.19 9.94 65 158613 11627 63318717
Choroidal haemorrhage 16.19 9.94 6 158672 55 63330289
Compartment syndrome 16.18 9.94 24 158654 2260 63328084
Paraplegia 16.02 9.94 26 158652 2646 63327698
Seroma 15.97 9.94 23 158655 2108 63328236
Gingival bleeding 15.88 9.94 68 158610 12519 63317825
Joint range of motion decreased 15.84 9.94 36 158642 32392 63297952
Respiratory tract infection 15.80 9.94 52 158626 41431 63288913
Platelet dysfunction 15.75 9.94 7 158671 106 63330238
Parkinsonian rest tremor 15.70 9.94 7 158671 107 63330237
Macroangiopathy 15.70 9.94 7 158671 107 63330237
Drug dependence 15.69 9.94 23 158655 24460 63305884
Device dislocation 15.65 9.94 25 158653 25680 63304664
Fungal infection 15.64 9.94 44 158634 36830 63293514
Atheroembolism 15.60 9.94 4 158674 8 63330336
Acute myeloid leukaemia 15.58 9.94 12 158666 17135 63313209
Splenic haematoma 15.58 9.94 7 158671 109 63330235
Myocardial rupture 15.55 9.94 6 158672 62 63330282
Vascular pseudoaneurysm ruptured 15.55 9.94 6 158672 62 63330282
Intracranial aneurysm 15.52 9.94 31 158647 3708 63326636
Essential hypertension 15.50 9.94 37 158641 4996 63325348
Activated partial thromboplastin time prolonged 15.44 9.94 45 158633 6848 63323496
Vascular encephalopathy 15.41 9.94 11 158667 430 63329914
Medication error 15.39 9.94 199 158479 52085 63278259
Orthostatic hypotension 15.39 9.94 148 158530 36012 63294332
Quadriparesis 15.36 9.94 22 158656 2007 63328337
Exercise tolerance increased 15.32 9.94 5 158673 30 63330314
Colitis ulcerative 15.31 9.94 26 158652 26065 63304279
Haemorrhagic diathesis 15.30 9.94 34 158644 4381 63325963
Influenza 15.25 9.94 186 158492 108536 63221808
Anal stenosis 15.14 9.94 11 158667 442 63329902
Chills 15.14 9.94 196 158482 113182 63217162
Device breakage 15.09 9.94 5 158673 11537 63318807
Prescribed overdose 15.05 9.94 40 158638 34113 63296231
Arteriogram coronary abnormal 14.99 9.94 4 158674 10 63330334
Coronary artery embolism 14.99 9.94 8 158670 184 63330160
Haemophagocytic lymphohistiocytosis 14.99 9.94 4 158674 10623 63319721
Hypothrombinaemia 14.98 9.94 3 158675 0 63330344
Mastocytic enterocolitis 14.98 9.94 3 158675 0 63330344
Malabsorption from application site 14.98 9.94 3 158675 0 63330344
Puncture site swelling 14.98 9.94 3 158675 0 63330344
Metastases to central nervous system 14.95 9.94 7 158671 13098 63317246
Impaired work ability 14.92 9.94 13 158665 17462 63312882
Nervous system disorder 14.92 9.94 89 158589 18677 63311667
Post procedural complication 14.90 9.94 83 158595 16991 63313353
Confusional state 14.89 9.94 728 157950 235652 63094692
Femoral neck fracture 14.83 9.94 51 158627 8472 63321872
Arterial disorder 14.80 9.94 17 158661 1244 63329100
Muscle abscess 14.78 9.94 10 158668 358 63329986
Hepatitis toxic 14.76 9.94 28 158650 3225 63327119
Angiogram 14.76 9.94 6 158672 72 63330272
Inappropriate antidiuretic hormone secretion 14.73 9.94 77 158601 15385 63314959
Brain contusion 14.72 9.94 12 158666 573 63329771
Incision site haemorrhage 14.72 9.94 12 158666 573 63329771
Haemorrhagic erosive gastritis 14.72 9.94 11 158667 462 63329882
Vascular stent insertion 14.72 9.94 4 158674 11 63330333
Blood pressure inadequately controlled 14.69 9.94 36 158642 4942 63325402
Anal polyp 14.68 9.94 6 158672 73 63330271
Lip infection 14.66 9.94 7 158671 126 63330218
Pituitary apoplexy 14.66 9.94 7 158671 126 63330218
Binocular eye movement disorder 14.66 9.94 5 158673 35 63330309
Injection site warmth 14.64 9.94 10 158668 15185 63315159
Palmar erythema 14.63 9.94 20 158658 1747 63328597
Gastrointestinal arteriovenous malformation 14.60 9.94 12 158666 580 63329764
Osteoarthritis 14.58 9.94 160 158518 95183 63235161
Hypertensive crisis 14.48 9.94 76 158602 15210 63315134
Implant site haematoma 14.47 9.94 6 158672 76 63330268
Brown-Sequard syndrome 14.46 9.94 4 158674 12 63330332
Pulmonary toxicity 14.44 9.94 3 158675 9452 63320892
Hypokinesia 14.40 9.94 71 158607 13865 63316479
Palmar-plantar erythrodysaesthesia syndrome 14.38 9.94 22 158656 22993 63307351
Cystitis noninfective 14.34 9.94 15 158663 988 63329356
Thalamic infarction 14.33 9.94 11 158667 481 63329863
Chest expansion decreased 14.31 9.94 5 158673 38 63330306
Cardiomegaly 14.30 9.94 84 158594 17530 63312814
Cerebral atrophy 14.28 9.94 36 158642 5030 63325314
Haematotoxicity 14.27 9.94 3 158675 9373 63320971
Carotid bruit 14.22 9.94 13 158665 726 63329618
Cardiorenal syndrome 14.18 9.94 14 158664 861 63329483
Thrombotic cerebral infarction 14.14 9.94 7 158671 137 63330207
Helicobacter gastritis 14.13 9.94 19 158659 1633 63328711
Coagulation time abnormal 14.12 9.94 6 158672 81 63330263
Symmetrical drug-related intertriginous and flexural exanthema 14.10 9.94 11 158667 493 63329851
Urinary straining 14.09 9.94 5 158673 40 63330304
Blood potassium increased 14.03 9.94 86 158592 18223 63312121
Ligament pain 14.00 9.94 8 158670 211 63330133
Cerebral artery occlusion 13.91 9.94 14 158664 881 63329463
Cardiac valve disease 13.90 9.94 32 158646 4220 63326124
Drug eruption 13.90 9.94 32 158646 28662 63301682
Uveitis 13.88 9.94 7 158671 12546 63317798
Functional gastrointestinal disorder 13.87 9.94 32 158646 4227 63326117
Myocardial necrosis marker increased 13.87 9.94 20 158658 1836 63328508
Blood creatinine increased 13.86 9.94 302 158376 87542 63242802
Oesophageal ulcer 13.82 9.94 33 158645 4457 63325887
Product complaint 13.77 9.94 66 158612 12743 63317601
Mediastinal haematoma 13.74 9.94 6 158672 87 63330257
Anuria 13.73 9.94 65 158613 12486 63317858
No adverse event 13.73 9.94 55 158623 41350 63288994
Intracranial mass 13.71 9.94 16 158662 1191 63329153
Chest discomfort 13.70 9.94 366 158312 109603 63220741
Pituitary haemorrhage 13.68 9.94 6 158672 88 63330256
Device issue 13.68 9.94 24 158654 23757 63306587
Obstructive shock 13.67 9.94 5 158673 44 63330300
Post viral fatigue syndrome 13.66 9.94 9 158669 308 63330036
Hypoglycaemic unconsciousness 13.66 9.94 13 158665 764 63329580
Ventricular dysfunction 13.65 9.94 25 158653 2803 63327541
Lip swelling 13.64 9.94 128 158550 30935 63299409
Anhedonia 13.62 9.94 59 158619 10915 63319429
Haemorrhagic thyroid cyst 13.58 9.94 4 158674 16 63330328
Posterior reversible encephalopathy syndrome 13.53 9.94 14 158664 17331 63313013
Pneumonitis 13.52 9.94 44 158634 35178 63295166
Drug ineffective for unapproved indication 13.46 9.94 42 158636 34021 63296323
Cardiac pacemaker insertion 13.43 9.94 31 158647 4095 63326249
Lower limb fracture 13.43 9.94 25 158653 24196 63306148
Intentional product misuse 13.42 9.94 93 158585 60824 63269520
Documented hypersensitivity to administered product 13.34 9.94 11 158667 534 63329810
Nuchal rigidity 13.32 9.94 12 158666 657 63329687
Blindness unilateral 13.27 9.94 40 158638 6201 63324143
Intestinal ischaemia 13.27 9.94 45 158633 7423 63322921
Abscess neck 13.26 9.94 12 158666 661 63329683
Blood parathyroid hormone decreased 13.23 9.94 4 158674 9787 63320557
Breast cancer 13.22 9.94 69 158609 48314 63282030
Exsanguination 13.20 9.94 4 158674 18 63330326
Agitation 13.07 9.94 216 158462 59541 63270803
Blindness 13.06 9.94 96 158582 21603 63308741
Nikolsky's sign 13.04 9.94 6 158672 99 63330245
Lacunar stroke 13.04 9.94 7 158671 163 63330181
Mucosal haemorrhage 12.97 9.94 15 158663 1106 63329238
Haemorrhagic cholecystitis 12.91 9.94 3 158675 3 63330341
Breast cancer stage II 12.88 9.94 3 158675 8733 63321611
Myoglobinaemia 12.86 9.94 4 158674 20 63330324
Subcapsular splenic haematoma 12.86 9.94 4 158674 20 63330324
General physical health deterioration 12.83 9.94 621 158057 200781 63129563
Gangrene 12.79 9.94 39 158639 6084 63324260
Tuberculosis 12.77 9.94 6 158672 11205 63319139
Eyelid oedema 12.75 9.94 56 158622 10423 63319921
Atrial thrombosis 12.73 9.94 19 158659 1799 63328545
Nasal congestion 12.68 9.94 104 158574 65556 63264788
Dislocation of vertebra 12.66 9.94 3 158675 8632 63321712
Mitral valve calcification 12.65 9.94 14 158664 984 63329360
Vascular purpura 12.65 9.94 17 158661 1461 63328883
Sweat gland tumour 12.62 9.94 6 158672 107 63330237
Injection site urticaria 12.60 9.94 10 158668 14063 63316281
Sinus rhythm 12.60 9.94 13 158665 843 63329501
Pericarditis constrictive 12.56 9.94 9 158669 354 63329990
Implantable defibrillator insertion 12.54 9.94 10 158668 463 63329881
Necrosis 12.46 9.94 36 158642 5451 63324893
Vascular insufficiency 12.46 9.94 8 158670 262 63330082
Cerebral artery stenosis 12.41 9.94 10 158668 470 63329874
Allergic cough 12.37 9.94 12 158666 722 63329622
Post cardiac arrest syndrome 12.25 9.94 4 158674 24 63330320
Long QT syndrome 12.21 9.94 26 158652 3253 63327091
Bacterial infection 12.16 9.94 87 158591 19412 63310932
Dialysis 12.14 9.94 55 158623 10372 63319972
Wheezing 12.13 9.94 167 158511 95428 63234916
Colitis ischaemic 12.11 9.94 56 158622 10652 63319692
Cystitis 12.11 9.94 199 158479 54792 63275552
Cerebellar ischaemia 12.08 9.94 5 158673 63 63330281
Burn oesophageal 12.07 9.94 7 158671 190 63330154
Duodenal vascular ectasia 12.05 9.94 3 158675 5 63330339
Reocclusion 12.05 9.94 3 158675 5 63330339
Vision blurred 12.05 9.94 308 158370 91616 63238728
Gastric antral vascular ectasia 12.00 9.94 11 158667 616 63329728
Neutrophil count decreased 11.99 9.94 87 158591 56319 63274025
Iliac vein occlusion 11.98 9.94 4 158674 26 63330318
Electrocardiogram ST-T change 11.98 9.94 14 158664 1044 63329300
Blood pressure diastolic increased 11.97 9.94 5 158673 10005 63320339
Tinnitus 11.95 9.94 139 158539 35489 63294855
Wound dehiscence 11.95 9.94 33 158645 4870 63325474
Akathisia 11.89 9.94 4 158674 9142 63321202
Aneurysm repair 11.85 9.94 4 158674 27 63330317
Wound haemorrhage 11.84 9.94 22 158656 2494 63327850
Dementia 11.80 9.94 84 158594 18710 63311634
Increased tendency to bruise 11.80 9.94 55 158623 10497 63319847
Appendicitis 11.79 9.94 3 158675 8226 63322118
Amenorrhoea 11.78 9.94 5 158673 9909 63320435
Illness 11.77 9.94 73 158605 48986 63281358
Diarrhoea 11.75 9.94 1588 157090 713778 62616566
Cardiovascular symptom 11.74 9.94 5 158673 68 63330276
Conjunctival haemorrhage 11.73 9.94 27 158651 3560 63326784
Balance disorder 11.70 9.94 285 158393 84137 63246207
Hepatic necrosis 11.67 9.94 36 158642 5651 63324693
Bone marrow failure 11.66 9.94 36 158642 29254 63301090
Skull fracture 11.59 9.94 14 158664 1081 63329263
X-ray abnormal 11.54 9.94 3 158675 8107 63322237
Bronchiectasis 11.53 9.94 14 158664 16128 63314216
Retinal detachment 11.53 9.94 37 158641 5932 63324412
Bleeding varicose vein 11.50 9.94 8 158670 300 63330044
Extremity necrosis 11.50 9.94 17 158661 1596 63328748
Hyporesponsive to stimuli 11.50 9.94 14 158664 1090 63329254
Gastrointestinal ulcer 11.49 9.94 20 158658 2155 63328189
Metastases to lung 11.49 9.94 9 158669 12741 63317603
Cold sweat 11.48 9.94 60 158618 11987 63318357
Wound haematoma 11.48 9.94 5 158673 72 63330272
Extravasation blood 11.48 9.94 5 158673 72 63330272
Hypovolaemic shock 11.44 9.94 38 158640 6203 63324141
Hepatic fibrosis 11.41 9.94 27 158651 3625 63326719
Blood pressure abnormal 11.40 9.94 71 158607 15127 63315217
Hepatic haemorrhage 11.39 9.94 10 158668 529 63329815
Superinfection fungal 11.39 9.94 3 158675 7 63330337
Atrial appendage closure 11.38 9.94 4 158674 31 63330313
Mental status changes 11.35 9.94 150 158528 39449 63290895
Agranulocytosis 11.26 9.94 104 158574 25030 63305314
Cerebellar infarction 11.24 9.94 19 158659 2000 63328344
Gastrointestinal ulcer haemorrhage 11.22 9.94 11 158667 671 63329673
Ventricle rupture 11.16 9.94 4 158674 33 63330311
Muscle hypertrophy 11.12 9.94 5 158673 78 63330266
Interventricular septum rupture 11.11 9.94 3 158675 8 63330336
Blood triglycerides increased 11.09 9.94 61 158617 12427 63317917
Influenza like illness 11.09 9.94 110 158568 66714 63263630
Ventricular hypokinesia 11.06 9.94 31 158647 4613 63325731
Vascular graft occlusion 11.04 9.94 7 158671 224 63330120
Hyperphosphataemia 11.01 9.94 20 158658 2228 63328116
Hepatitis cholestatic 10.97 9.94 40 158638 6838 63323506
Asthma 10.97 9.94 239 158439 127322 63203022
Dystonia 10.95 9.94 11 158667 13808 63316536
Left ventricular dysfunction 10.94 9.94 59 158619 11929 63318415
Metastases to liver 10.94 9.94 27 158651 23612 63306732
Haemorrhagic arteriovenous malformation 10.94 9.94 6 158672 146 63330198
Rectal perforation 10.93 9.94 9 158669 436 63329908
Gastrointestinal injury 10.88 9.94 10 158668 562 63329782
Photophobia 10.88 9.94 17 158661 17618 63312726
Fat embolism 10.88 9.94 7 158671 230 63330114
Kidney fibrosis 10.87 9.94 18 158660 1863 63328481
Colonic haematoma 10.86 9.94 4 158674 36 63330308
Thalamus haemorrhage 10.86 9.94 11 158667 698 63329646
Traumatic haemorrhage 10.85 9.94 10 158668 564 63329780
Puncture site haematoma 10.85 9.94 3 158675 9 63330335
Phlebitis deep 10.85 9.94 3 158675 9 63330335
Pulmonary haemorrhage 10.82 9.94 41 158637 7140 63323204
Blood creatine phosphokinase MM increased 10.67 9.94 4 158674 38 63330306
Eyelid bleeding 10.67 9.94 4 158674 38 63330306
Platelet disorder 10.62 9.94 18 158660 1898 63328446
Arterial rupture 10.62 9.94 8 158670 340 63330004
Vascular access site haemorrhage 10.61 9.94 3 158675 10 63330334
Gastritis haemorrhagic 10.61 9.94 16 158662 1529 63328815
Rales 10.60 9.94 61 158617 12636 63317708
Bradyarrhythmia 10.60 9.94 19 158659 2096 63328248
Aortic valve incompetence 10.57 9.94 36 158642 5952 63324392
Cerebrovascular insufficiency 10.52 9.94 5 158673 89 63330255
Electrolyte imbalance 10.52 9.94 86 158592 19990 63310354
Sciatica 10.51 9.94 47 158631 34277 63296067
Aldolase increased 10.48 9.94 6 158672 159 63330185
Chronic sinusitis 10.44 9.94 10 158668 12833 63317511
Ruptured cerebral aneurysm 10.44 9.94 9 158669 465 63329879
Electrocardiogram abnormal 10.38 9.94 48 158630 9131 63321213
Adrenal insufficiency 10.37 9.94 18 158660 17897 63312447
Foetal growth restriction 10.36 9.94 3 158675 7550 63322794
Coeliac disease 10.36 9.94 10 158668 12787 63317557
Device difficult to use 10.36 9.94 10 158668 12786 63317558
Pelvic haematoma 10.35 9.94 10 158668 599 63329745
Hip fracture 10.34 9.94 116 158562 29358 63300986
Microangiopathy 10.32 9.94 14 158664 1214 63329130
Skin fissures 10.31 9.94 8 158670 11380 63318964
Brain stem ischaemia 10.28 9.94 5 158673 94 63330250
Large intestinal ulcer 10.26 9.94 25 158653 3419 63326925
Gastroenteritis viral 10.26 9.94 28 158650 23672 63306672
Interstitial lung disease 10.23 9.94 102 158576 61806 63268538
Ovarian cyst 10.20 9.94 15 158663 15930 63314414
Skin flap necrosis 10.18 9.94 3 158675 12 63330332
Brain stem haemorrhage 10.15 9.94 11 158667 755 63329589
Oral contusion 10.14 9.94 5 158673 97 63330247
Dilatation atrial 10.12 9.94 18 158660 1973 63328371
Urinary tract infection staphylococcal 10.11 9.94 8 158670 366 63329978
Rash papulosquamous 10.09 9.94 5 158673 98 63330246
Troponin T increased 10.09 9.94 14 158664 1240 63329104
Cholestatic liver injury 10.08 9.94 21 158657 2589 63327755
Nausea 10.06 9.94 1933 156745 852538 62477806
Aortic rupture 10.04 9.94 5 158673 99 63330245
Basal cell carcinoma 10.04 9.94 36 158642 27955 63302389
Aortic thrombosis 9.96 9.94 13 158665 1086 63329258

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 1913.76 10.94 2881 198581 118204 34637265
Acute myocardial infarction 1162.69 10.94 1489 199973 52230 34703239
Gastrointestinal haemorrhage 1121.90 10.94 1906 199556 86571 34668898
Coronary artery disease 979.78 10.94 1297 200165 47008 34708461
Melaena 871.62 10.94 1047 200415 34333 34721136
Labelled drug-drug interaction medication error 649.69 10.94 599 200863 14340 34741129
Coronary arterial stent insertion 628.49 10.94 355 201107 3774 34751695
Vascular stent thrombosis 582.67 10.94 301 201161 2634 34752835
Angina pectoris 573.19 10.94 801 200661 30562 34724907
Cerebrovascular accident 522.40 10.94 1360 200102 83451 34672018
Thrombosis in device 474.21 10.94 274 201188 3051 34752418
Off label use 441.69 10.94 1118 200344 418406 34337063
Haemorrhage 425.85 10.94 925 200537 50445 34705024
Toxicity to various agents 411.83 10.94 331 201131 200031 34555438
Cerebral haemorrhage 405.86 10.94 725 200737 34212 34721257
Upper gastrointestinal haemorrhage 402.53 10.94 608 200854 24910 34730559
Drug abuse 400.00 10.94 50 201412 99046 34656423
Angina unstable 393.76 10.94 407 201055 11246 34744223
Chest pain 389.93 10.94 1604 199858 125158 34630311
Gastric haemorrhage 362.34 10.94 367 201095 9894 34745575
Subdural haematoma 354.45 10.94 509 200953 19912 34735557
Febrile neutropenia 343.67 10.94 180 201282 136669 34618800
Anaemia 336.02 10.94 2397 199065 230938 34524531
Haematemesis 333.36 10.94 584 200878 27127 34728342
Haematuria 325.71 10.94 820 200642 49246 34706223
Haematochezia 320.51 10.94 779 200683 45755 34709714
Cardiac failure congestive 310.98 10.94 1121 200341 82149 34673320
Coronary artery stenosis 293.18 10.94 318 201144 9298 34746171
Coronary artery occlusion 290.56 10.94 337 201125 10625 34744844
Rectal haemorrhage 288.14 10.94 684 200778 39565 34715904
Acute coronary syndrome 277.79 10.94 366 201096 13179 34742290
Haematoma 272.85 10.94 512 200950 25093 34730376
Drug ineffective 255.89 10.94 1566 199896 455185 34300284
Haemorrhage intracranial 222.26 10.94 359 201103 15587 34739882
Pyrexia 220.60 10.94 1079 200383 331934 34423535
Drug interaction 217.10 10.94 2120 199342 223826 34531643
Coronary artery restenosis 205.11 10.94 106 201356 928 34754541
Lower gastrointestinal haemorrhage 180.95 10.94 247 201215 9205 34746264
Completed suicide 174.32 10.94 185 201277 97983 34657486
Vascular stent stenosis 172.88 10.94 99 201363 1082 34754387
Disease progression 172.24 10.94 222 201240 107855 34647614
Blood loss anaemia 167.36 10.94 221 201241 7973 34747496
Neutropenia 166.24 10.94 415 201047 156363 34599106
Stent placement 165.50 10.94 174 201288 4904 34750565
Product use in unapproved indication 164.91 10.94 264 201198 117235 34638234
Transient ischaemic attack 159.74 10.94 433 201029 27180 34728289
Epistaxis 159.37 10.94 712 200750 57539 34697930
Foetal exposure during pregnancy 156.66 10.94 18 201444 38083 34717386
Post procedural haemorrhage 154.75 10.94 214 201248 8075 34747394
Cerebral infarction 153.33 10.94 425 201037 27030 34728439
Ischaemic stroke 150.36 10.94 328 201134 17922 34737547
Coronary artery thrombosis 148.78 10.94 113 201349 2046 34753423
Syncope 146.80 10.94 966 200496 90485 34664984
Coronary artery bypass 142.29 10.94 158 201304 4744 34750725
Faeces discoloured 141.96 10.94 284 201178 14594 34740875
Subarachnoid haemorrhage 140.01 10.94 257 201205 12378 34743091
Vascular pseudoaneurysm 135.35 10.94 107 201355 2060 34753409
Infusion related reaction 134.19 10.94 69 201393 52988 34702481
Carotid artery stenosis 134.17 10.94 155 201307 4864 34750605
Dizziness 133.17 10.94 1879 199583 216642 34538827
Death 133.03 10.94 1562 199900 396487 34358982
Malignant neoplasm progression 132.02 10.94 189 201273 87857 34667612
Myocardial ischaemia 129.04 10.94 300 201162 17108 34738361
Haemoglobin decreased 127.03 10.94 1156 200306 119616 34635853
Haemoptysis 126.89 10.94 467 200995 34539 34720930
Retroperitoneal haematoma 125.44 10.94 112 201350 2566 34752903
Therapeutic product effect incomplete 124.48 10.94 68 201394 50473 34704996
Rhabdomyolysis 123.66 10.94 743 200719 67420 34688049
Insulin autoimmune syndrome 120.61 10.94 50 201412 246 34755223
Cardiac disorder 119.33 10.94 529 200933 42597 34712872
Cytokine release syndrome 110.52 10.94 5 201457 22872 34732597
Gastritis erosive 109.01 10.94 152 201310 5780 34749689
Arterial occlusive disease 107.80 10.94 129 201333 4205 34751264
Cardiac failure 106.61 10.94 894 200568 90354 34665115
Treatment failure 103.61 10.94 71 201391 46626 34708843
Cerebral haematoma 98.17 10.94 127 201335 4488 34750981
COVID-19 98.04 10.94 186 201276 77364 34678105
Shock haemorrhagic 98.03 10.94 208 201254 11146 34744323
White blood cell count decreased 96.95 10.94 258 201204 95187 34660282
Pneumonia 95.99 10.94 1492 199970 361135 34394334
Thrombotic thrombocytopenic purpura 93.33 10.94 106 201356 3264 34752205
Product administration error 93.22 10.94 255 201207 16089 34739380
Cytomegalovirus infection 92.33 10.94 19 201443 26116 34729353
Duodenal ulcer haemorrhage 91.45 10.94 128 201334 4885 34750584
Peripheral arterial occlusive disease 91.21 10.94 139 201323 5735 34749734
Intermittent claudication 90.15 10.94 87 201375 2207 34753262
Fall 89.50 10.94 1654 199808 201231 34554238
Respiratory tract haemorrhage 88.68 10.94 67 201395 1203 34754266
Hemiparesis 87.83 10.94 244 201218 15534 34739935
Multiple injuries 86.28 10.94 78 201384 1817 34753652
Haemorrhagic stroke 85.41 10.94 143 201319 6396 34749073
Gastric ulcer 85.13 10.94 240 201222 15410 34740059
Stomatitis 82.49 10.94 74 201388 42440 34713029
Haemorrhagic transformation stroke 82.06 10.94 69 201393 1454 34754015
Mucosal inflammation 81.40 10.94 62 201400 38560 34716909
Duodenal ulcer 80.93 10.94 182 201280 10150 34745319
Sepsis 80.67 10.94 595 200867 165966 34589503
Muscle haemorrhage 80.16 10.94 103 201359 3615 34751854
Drug dependence 76.96 10.94 22 201440 24195 34731274
Cardiac tamponade 75.34 10.94 120 201342 5146 34750323
Pancytopenia 75.09 10.94 288 201174 94869 34660600
Diverticulum intestinal haemorrhagic 73.89 10.94 82 201380 2460 34753009
Diarrhoea 73.54 10.94 1700 199762 388212 34367257
Drug intolerance 73.43 10.94 145 201317 59425 34696044
Iron deficiency anaemia 72.20 10.94 174 201288 10155 34745314
Coronary angioplasty 71.83 10.94 39 201423 381 34755088
Dyspnoea 71.14 10.94 2747 198715 374035 34381434
Arthralgia 71.06 10.94 632 200830 169409 34586060
Ischaemic cardiomyopathy 70.83 10.94 130 201332 6259 34749210
Haemobilia 70.44 10.94 38 201424 366 34755103
Angioplasty 69.90 10.94 53 201409 957 34754512
Gingival bleeding 69.64 10.94 136 201326 6864 34748605
Subdural haemorrhage 68.17 10.94 88 201374 3103 34752366
Mitral valve incompetence 67.87 10.94 215 201247 14728 34740741
Mallory-Weiss syndrome 67.05 10.94 59 201403 1325 34754144
Neuropathy peripheral 66.33 10.94 251 201211 83012 34672457
Infection 66.17 10.94 284 201178 90631 34664838
Hemiplegia 65.20 10.94 132 201330 6840 34748629
International normalised ratio increased 64.73 10.94 481 200981 46846 34708623
Psychotic disorder 64.54 10.94 30 201432 24422 34731047
Arteriosclerosis 63.60 10.94 182 201280 11786 34743683
Occult blood positive 63.15 10.94 96 201366 3952 34751517
Presyncope 63.05 10.94 247 201215 18812 34736657
Intraventricular haemorrhage 62.69 10.94 89 201373 3442 34752027
Product dose omission issue 62.14 10.94 419 201043 119292 34636177
Intentional product use issue 62 10.94 160 201302 59656 34695813
Serotonin syndrome 61.71 10.94 19 201443 19914 34735555
Rheumatoid arthritis 61.41 10.94 78 201384 38160 34717309
Cardiac aneurysm 61.24 10.94 48 201414 912 34754557
Occult blood 61.07 10.94 46 201416 822 34754647
Intentional product misuse 60.66 10.94 106 201356 45505 34709964
Myelosuppression 60.30 10.94 18 201444 19247 34736222
Premature baby 60.27 10.94 19 201443 19614 34735855
Myalgia 60.09 10.94 745 200717 83365 34672104
Pericardial haemorrhage 59.64 10.94 82 201380 3076 34752393
Neuroleptic malignant syndrome 59.42 10.94 15 201447 17919 34737550
Aphasia 59.19 10.94 263 201199 21191 34734278
Troponin increased 58.40 10.94 171 201291 11218 34744251
Post procedural haematoma 58.33 10.94 57 201405 1469 34754000
Neutrophil count decreased 58.27 10.94 130 201332 50974 34704495
Extradural haematoma 58.23 10.94 51 201411 1138 34754331
Overdose 57.71 10.94 299 201163 90760 34664709
Retroperitoneal haemorrhage 57.60 10.94 77 201385 2811 34752658
Peripheral artery stenosis 56.50 10.94 44 201418 828 34754641
Weight increased 56.45 10.94 310 201152 92723 34662746
Ventricular tachycardia 56.24 10.94 302 201160 26277 34729192
Hypoglycaemia 55.32 10.94 519 200943 54121 34701348
Sinusitis 55.25 10.94 96 201366 41306 34714163
Hyphaema 54.90 10.94 37 201425 550 34754919
Synovitis 54.55 10.94 8 201454 14058 34741411
Spinal cord haemorrhage 54.40 10.94 30 201432 303 34755166
Gastric ulcer haemorrhage 54.14 10.94 106 201356 5360 34750109
Product prescribing error 53.70 10.94 268 201194 22659 34732810
Coronary artery dissection 53.70 10.94 29 201433 280 34755189
Leukopenia 53.69 10.94 184 201278 62672 34692797
Gastritis 53.61 10.94 259 201203 21614 34733855
Electrocardiogram Q wave abnormal 53.60 10.94 33 201429 416 34755053
Bleeding time prolonged 53.37 10.94 38 201424 620 34754849
Product use issue 53.36 10.94 186 201276 63030 34692439
Contraindicated product administered 53.11 10.94 255 201207 21226 34734243
Ventricular hypokinesia 52.98 10.94 106 201356 5446 34750023
Spinal epidural haematoma 52.83 10.94 29 201433 290 34755179
Device occlusion 52.05 10.94 116 201346 6429 34749040
Pulmonary alveolar haemorrhage 51.92 10.94 126 201336 7386 34748083
Percutaneous coronary intervention 51.66 10.94 26 201436 214 34755255
Drug ineffective for unapproved indication 51.35 10.94 37 201425 23678 34731791
Conjunctival haemorrhage 51.31 10.94 75 201387 2980 34752489
Neurotoxicity 50.88 10.94 20 201442 17990 34737479
Pulmonary haematoma 50.77 10.94 18 201444 52 34755417
Intra-abdominal haematoma 50.19 10.94 50 201412 1320 34754149
Suicide attempt 50.13 10.94 93 201369 39023 34716446
Haemothorax 49.99 10.94 84 201378 3768 34751701
Electrocardiogram ST segment elevation 48.78 10.94 99 201363 5139 34750330
Duodenitis 48.27 10.94 94 201368 4734 34750735
Fractional exhaled nitric oxide increased 48.21 10.94 44 201418 1038 34754431
Vascular stent occlusion 48.01 10.94 23 201439 168 34755301
Septic shock 47.72 10.94 232 201230 71602 34683867
Asthenia 47.54 10.94 1794 199668 243457 34512012
Arterial stenosis 47.30 10.94 45 201417 1121 34754348
Injury 47.17 10.94 240 201222 20447 34735022
Hepatojugular reflux 47.12 10.94 34 201428 567 34754902
Neoplasm progression 47.09 10.94 39 201423 23261 34732208
Procedural haemorrhage 46.71 10.94 64 201398 2393 34753076
Microcytic anaemia 46.36 10.94 63 201399 2337 34753132
Vascular graft occlusion 45.81 10.94 33 201429 549 34754920
Arterial restenosis 45.64 10.94 17 201445 59 34755410
Chest discomfort 45.61 10.94 498 200964 54032 34701437
Kounis syndrome 45.49 10.94 64 201398 2454 34753015
Coronary artery perforation 45.44 10.94 16 201446 45 34755424
Rash 45.32 10.94 959 200503 221793 34533676
Loss of personal independence in daily activities 45.13 10.94 76 201386 33103 34722366
Pneumocystis jirovecii pneumonia 45.02 10.94 29 201433 19681 34735788
Atrial fibrillation 44.88 10.94 971 200491 121422 34634047
Acquired haemophilia 44.86 10.94 41 201421 969 34754500
Fat embolism 44.78 10.94 22 201440 171 34755298
Blood cholesterol 44.44 10.94 23 201439 202 34755267
Ulcer haemorrhage 44.05 10.94 65 201397 2605 34752864
Bone marrow failure 43.60 10.94 63 201399 29190 34726279
Haemorrhagic ascites 43.57 10.94 20 201442 131 34755338
Spinal subarachnoid haemorrhage 43.44 10.94 15 201447 39 34755430
Hypotension 43.33 10.94 1623 199839 220026 34535443
Musculoskeletal stiffness 43.09 10.94 132 201330 46548 34708921
Platelet count decreased 42.79 10.94 462 201000 119255 34636214
Gastritis haemorrhagic 42.51 10.94 47 201415 1404 34754065
Therapeutic product effect decreased 42.43 10.94 85 201377 34658 34720811
Dyspnoea exertional 42.27 10.94 408 201054 42871 34712598
Ecchymosis 41.67 10.94 109 201353 6694 34748775
Normocytic anaemia 41.49 10.94 59 201403 2285 34753184
Condition aggravated 40.99 10.94 821 200641 191375 34564094
Therapy partial responder 40.91 10.94 4 201458 9612 34745857
Angiocardiogram 40.91 10.94 21 201441 181 34755288
Peripheral vascular disorder 40.89 10.94 90 201372 4946 34750523
Pulmonary embolism 40.84 10.94 326 201136 89420 34666049
Vascular graft 40.67 10.94 47 201415 1475 34753994
N-terminal prohormone brain natriuretic peptide increased 40.40 10.94 63 201399 2652 34752817
Inappropriate schedule of product administration 40.34 10.94 203 201259 62093 34693376
Bronchopulmonary aspergillosis 40.24 10.94 17 201445 14642 34740827
Posterior reversible encephalopathy syndrome 40.17 10.94 5 201457 9949 34745520
Embolic stroke 40.08 10.94 83 201379 4371 34751098
Dyspnoea at rest 40.07 10.94 76 201386 3752 34751717
Aggression 39.77 10.94 105 201357 38859 34716610
Suicidal ideation 39.61 10.94 111 201351 40277 34715192
Degenerative mitral valve disease 39.57 10.94 23 201439 259 34755210
Myoglobin blood increased 39.34 10.94 66 201396 2957 34752512
Haemorrhage urinary tract 38.97 10.94 51 201411 1823 34753646
Small intestinal haemorrhage 38.75 10.94 54 201408 2052 34753417
Ejection fraction decreased 38.74 10.94 215 201247 18939 34736530
Blood creatine phosphokinase MB increased 38.71 10.94 51 201411 1835 34753634
Bradycardia 38.22 10.94 629 200833 74789 34680680
Contusion 38.10 10.94 348 201114 36016 34719453
Dystonia 38.06 10.94 8 201454 10837 34744632
Somnolence 38.04 10.94 433 201029 110683 34644786
Drug withdrawal syndrome 37.90 10.94 35 201427 19799 34735670
Gastrointestinal polyp haemorrhage 37.83 10.94 24 201438 320 34755149
Haemorrhage subcutaneous 37.51 10.94 56 201406 2268 34753201
Exposure during pregnancy 37.27 10.94 4 201458 8930 34746539
Myocardial rupture 37.19 10.94 19 201443 162 34755307
Platelet function test abnormal 37.08 10.94 17 201445 111 34755358
Splenic rupture 36.91 10.94 45 201417 1496 34753973
Spontaneous haemorrhage 36.89 10.94 23 201439 297 34755172
Sedation 36.78 10.94 40 201422 20966 34734503
Peripheral ischaemia 36.78 10.94 93 201369 5594 34749875
Alopecia 36.75 10.94 52 201410 24303 34731166
Plasma cell myeloma 36.61 10.94 122 201340 41915 34713554
Respiratory failure 36.42 10.94 425 201037 108147 34647322
Acute myeloid leukaemia 36.40 10.94 31 201431 18239 34737230
Immune reconstitution inflammatory syndrome 36.34 10.94 4 201458 8755 34746714
C-reactive protein increased 36.34 10.94 174 201288 53924 34701545
Dermatitis exfoliative 36.29 10.94 102 201360 6537 34748932
Injection site pain 36.21 10.94 110 201352 38895 34716574
Cytopenia 36.15 10.94 14 201448 12709 34742760
Inferior vena cava dilatation 36.02 10.94 32 201430 728 34754741
Pallor 35.99 10.94 261 201201 25219 34730250
Haematotoxicity 35.96 10.94 3 201459 8191 34747278
Intentional overdose 35.85 10.94 130 201332 43544 34711925
Heparin-induced thrombocytopenia 35.67 10.94 91 201371 5504 34749965
Asthma 35.65 10.94 126 201336 42530 34712939
Lower respiratory tract infection 35.63 10.94 81 201381 31556 34723913
Gastrointestinal angiodysplasia 35.59 10.94 29 201433 584 34754885
Cardiac failure chronic 35.44 10.94 113 201349 7766 34747703
Encephalopathy 35.43 10.94 96 201366 35223 34720246
Pathogen resistance 35.40 10.94 6 201456 9476 34745993
Page kidney 35.37 10.94 13 201449 43 34755426
Puncture site haemorrhage 35.22 10.94 22 201440 285 34755184
Chronic kidney disease 35.22 10.94 378 201084 40832 34714637
Orthostatic hypotension 35.19 10.94 263 201199 25656 34729813
Systolic dysfunction 35.07 10.94 59 201403 2649 34752820
Oxygen saturation decreased 35.05 10.94 175 201287 53643 34701826
Infective exacerbation of chronic obstructive airways disease 34.86 10.94 48 201414 1803 34753666
Insomnia 34.75 10.94 407 201055 103500 34651969
Nasopharyngitis 34.75 10.94 248 201214 69720 34685749
Intentional self-injury 34.67 10.94 18 201444 13753 34741716
Urogenital haemorrhage 34.58 10.94 31 201431 714 34754755
Joint swelling 34.46 10.94 203 201259 59687 34695782
Oropharyngeal pain 34.44 10.94 98 201364 35387 34720082
Angiopathy 34.36 10.94 75 201387 4098 34751371
Mesenteric artery thrombosis 34.29 10.94 25 201437 424 34755045
Plantar fasciitis 34.17 10.94 51 201411 2065 34753404
Eosinophilia 33.87 10.94 263 201199 25959 34729510
Coagulation time abnormal 33.87 10.94 17 201445 139 34755330
Poisoning 33.84 10.94 14 201448 12212 34743257
Arteriosclerosis coronary artery 33.65 10.94 152 201310 12333 34743136
Haemorrhagic infarction 32.94 10.94 25 201437 452 34755017
Fatigue 32.92 10.94 1774 199688 368879 34386590
Mediastinal haematoma 32.83 10.94 15 201447 97 34755372
Hospitalisation 32.67 10.94 193 201269 56709 34698760
Colitis 32.57 10.94 110 201352 37640 34717829
Vitreous haemorrhage 32.48 10.94 53 201409 2320 34753149
Drug hypersensitivity 32.40 10.94 302 201160 80227 34675242
Appendicitis 32.19 10.94 23 201439 14784 34740685
Subcutaneous haematoma 32.14 10.94 34 201428 965 34754504
Normochromic normocytic anaemia 31.89 10.94 74 201388 4213 34751256
Ischaemia 31.84 10.94 77 201385 4503 34750966
Intracardiac thrombus 31.82 10.94 54 201408 2442 34753027
Atheroembolism 31.34 10.94 21 201441 309 34755160
Mouth haemorrhage 31.34 10.94 84 201378 5235 34750234
Cardiac ventricular thrombosis 31.30 10.94 36 201426 1124 34754345
Prostate cancer 31.25 10.94 120 201342 39529 34715940
Herpes zoster 31.23 10.94 98 201364 34301 34721168
Tachycardia 31.14 10.94 325 201137 84447 34671022
Hiatus hernia 31.13 10.94 106 201356 7539 34747930
Device related infection 31.10 10.94 32 201430 17205 34738264
Helicobacter gastritis 31.09 10.94 37 201425 1199 34754270
Head injury 31.03 10.94 195 201267 17965 34737504
Influenza 30.93 10.94 164 201298 49502 34705967
Blood pressure decreased 30.84 10.94 442 201020 51073 34704396
Constipation 30.74 10.94 580 200882 136402 34619067
Wound haemorrhage 30.50 10.94 48 201414 2037 34753432
Pulmonary vascular disorder 30.49 10.94 28 201434 666 34754803
Haemorrhagic arteriovenous malformation 30.43 10.94 22 201440 368 34755101
Nausea 30.14 10.94 1627 199835 338281 34417188
Shone complex 30.11 10.94 13 201449 72 34755397
Transplant rejection 29.88 10.94 11 201451 10300 34745169
Venoocclusive liver disease 29.83 10.94 5 201457 7961 34747508
Haemophagocytic lymphohistiocytosis 29.75 10.94 19 201443 12954 34742515
Coronary revascularisation 29.52 10.94 10 201452 24 34755445
Catheter site haematoma 29.49 10.94 16 201446 156 34755313
Cytomegalovirus viraemia 29.34 10.94 4 201458 7426 34748043
Adverse drug reaction 29.24 10.94 80 201382 29262 34726207
Infarction 29.24 10.94 55 201407 2698 34752771
Poisoning deliberate 29.20 10.94 5 201457 7839 34747630
Multiple organ dysfunction syndrome 29.17 10.94 291 201171 76275 34679194
Carotid arteriosclerosis 28.89 10.94 44 201418 1814 34753655
Irritability 28.80 10.94 62 201400 24628 34730841
Lymphocyte count decreased 28.79 10.94 54 201408 22568 34732901
Agitation 28.71 10.94 203 201259 57196 34698273
Peripheral artery occlusion 28.71 10.94 42 201420 1670 34753799
Haemorrhagic cholecystitis 28.59 10.94 13 201449 83 34755386
Vomiting 28.59 10.94 1152 200310 246469 34509000
Gastrointestinal vascular malformation haemorrhagic 28.57 10.94 26 201436 611 34754858
Carotid artery occlusion 28.34 10.94 65 201397 3672 34751797
Epstein-Barr virus infection 28.10 10.94 5 201457 7623 34747846
Brain natriuretic peptide increased 28.09 10.94 84 201378 5575 34749894
Aortic stenosis 27.90 10.94 71 201391 4287 34751182
Ascites 27.78 10.94 156 201306 46415 34709054
Coronary artery reocclusion 27.72 10.94 13 201449 90 34755379
Myocarditis 27.52 10.94 23 201439 13659 34741810
Arterial intramural haematoma 27.40 10.94 11 201451 49 34755420
Blood pressure fluctuation 27.35 10.94 66 201396 25183 34730286
Respiratory depression 27.28 10.94 32 201430 16213 34739256
Peripheral swelling 27.08 10.94 296 201166 76245 34679224
Atrial thrombosis 27.04 10.94 47 201415 2167 34753302
Respiratory arrest 26.81 10.94 78 201384 27965 34727504
Hepatic encephalopathy 26.79 10.94 27 201435 14658 34740811
Anaemia macrocytic 26.77 10.94 56 201406 2970 34752499
Hallucination, auditory 26.58 10.94 18 201444 11899 34743570
Sudden cardiac death 26.57 10.94 63 201399 3638 34751831
Abdominal wall haematoma 26.47 10.94 42 201420 1795 34753674
Coagulation time prolonged 26.40 10.94 35 201427 1267 34754202
Sensation of foreign body 26.39 10.94 53 201409 2730 34752739
Pain 26.31 10.94 940 200522 203735 34551734
Deep vein thrombosis 26.11 10.94 245 201217 65003 34690466
Lacunar infarction 25.97 10.94 56 201406 3034 34752435
Aorta hypoplasia 25.72 10.94 12 201450 82 34755387
Alanine aminotransferase increased 25.70 10.94 320 201142 80495 34674974
Petechiae 25.63 10.94 115 201347 9303 34746166
Splenic haematoma 25.58 10.94 15 201447 172 34755297
Circulatory collapse 25.53 10.94 208 201254 20830 34734639
Aspergillus infection 25.40 10.94 20 201442 12234 34743235
Laryngeal haemorrhage 25.39 10.94 9 201453 26 34755443
Cerebral hyperperfusion syndrome 25.36 10.94 12 201450 85 34755384
Skin flap necrosis 25.28 10.94 8 201454 14 34755455
Lymphadenopathy 25.20 10.94 82 201380 28381 34727088
Hemiataxia 25.19 10.94 10 201452 43 34755426
Fungal infection 25.07 10.94 33 201429 15902 34739567
Helicobacter test positive 25.04 10.94 28 201434 847 34754622
Vessel puncture site haematoma 24.83 10.94 10 201452 45 34755424
Labelled drug-disease interaction medication error 24.75 10.94 13 201449 118 34755351
Pituitary haemorrhage 24.64 10.94 15 201447 185 34755284
Akathisia 24.62 10.94 8 201454 8101 34747368
Blood phosphorus increased 24.55 10.94 7 201455 7714 34747755
Stenosis 24.50 10.94 36 201426 1437 34754032
Post procedural complication 24.50 10.94 130 201332 11258 34744211
Depression 24.36 10.94 403 201059 96695 34658774
Thrombotic cerebral infarction 24.24 10.94 19 201443 361 34755108
Upper respiratory tract infection 24.19 10.94 103 201359 32956 34722513
Arthropathy 24.18 10.94 77 201385 26830 34728639
C-reactive protein abnormal 24.07 10.94 10 201452 8700 34746769
Pneumonitis 23.91 10.94 107 201355 33771 34721698
Purpura 23.77 10.94 120 201342 10191 34745278
Eye injury 23.75 10.94 27 201435 832 34754637
Prostatic adenoma 23.69 10.94 14 201448 163 34755306
Low birth weight baby 23.65 10.94 8 201454 7897 34747572
Aspartate aminotransferase increased 23.63 10.94 263 201199 67520 34687949
Nicotine dependence 23.46 10.94 23 201439 595 34754874
Therapy non-responder 23.42 10.94 131 201331 39015 34716454
Renal haemorrhage 23.36 10.94 35 201427 1422 34754047
Acute pulmonary oedema 23.34 10.94 94 201368 7249 34748220
Cellulitis 23.32 10.94 194 201268 52757 34702712
Aortic valve incompetence 23.29 10.94 81 201381 5823 34749646
Neutropenic sepsis 23.24 10.94 27 201435 13740 34741729
Iliac artery stenosis 23.23 10.94 11 201451 78 34755391
Therapeutic response shortened 23.02 10.94 7 201455 7397 34748072
Blood bilirubin increased 22.99 10.94 128 201334 38168 34717301
Intracranial haematoma 22.96 10.94 20 201442 443 34755026
Thrombocytopenic purpura 22.89 10.94 31 201431 1146 34754323
Psoriatic arthropathy 22.86 10.94 50 201412 19748 34735721
Chills 22.83 10.94 329 201133 80714 34674755
Candida infection 22.80 10.94 42 201420 17673 34737796
Cerebellar haemorrhage 22.75 10.94 36 201426 1535 34753934
Parinaud syndrome 22.56 10.94 6 201456 3 34755466
Schizophrenia 22.30 10.94 11 201451 8655 34746814
Electrocardiogram ST segment depression 22.22 10.94 46 201416 2422 34753047
Gastrointestinal tract mucosal pigmentation 21.98 10.94 20 201442 470 34754999
Nipple exudate bloody 21.93 10.94 6 201456 4 34755465
Mesenteric arterial occlusion 21.92 10.94 9 201453 43 34755426
Multiple sclerosis relapse 21.91 10.94 26 201436 13107 34742362
Haemarthrosis 21.81 10.94 54 201408 3205 34752264
Cardiovascular disorder 21.77 10.94 115 201347 9941 34745528
Cardiac arrest 21.68 10.94 716 200746 95443 34660026
Hyperbilirubinaemia 21.62 10.94 40 201422 16803 34738666
Pneumonia fungal 21.56 10.94 7 201455 7093 34748376
Creatinine renal clearance decreased 21.56 10.94 55 201407 3326 34752143
Subacute hepatic failure 21.51 10.94 11 201451 94 34755375
Supravalvular aortic stenosis 21.43 10.94 9 201453 46 34755423
Intestinal haemorrhage 21.40 10.94 56 201406 3440 34752029
CYP2C19 polymorphism 21.36 10.94 6 201456 5 34755464
Vascular occlusion 21.27 10.94 27 201435 936 34754533
Osteoporosis 21.22 10.94 25 201437 12643 34742826
Injection site erythema 21.08 10.94 37 201425 15862 34739607
Bacteraemia 20.99 10.94 52 201410 19665 34735804
Tardive dyskinesia 20.89 10.94 4 201458 5786 34749683
Cerebral mass effect 20.83 10.94 27 201435 956 34754513
Product shape issue 20.81 10.94 5 201457 0 34755469
Wrong dosage formulation 20.81 10.94 5 201457 0 34755469
Catheterisation cardiac 20.79 10.94 47 201415 2630 34752839
Tricuspid valve incompetence 20.71 10.94 111 201351 9649 34745820
BK virus infection 20.62 10.94 4 201458 5734 34749735
Reperfusion injury 20.54 10.94 10 201452 76 34755393
Anxiety 20.48 10.94 427 201035 99001 34656468
Traumatic haematoma 20.43 10.94 23 201439 701 34754768
Traumatic haemorrhage 20.42 10.94 24 201438 767 34754702
Subcapsular renal haematoma 20.39 10.94 18 201444 406 34755063
Incision site haemorrhage 20.17 10.94 20 201442 525 34754944
Quadriparesis 20.08 10.94 34 201428 1535 34753934
Palpitations 20.06 10.94 333 201129 39653 34715816
Colonic haematoma 20.04 10.94 8 201454 35 34755434
Thyroid haemorrhage 19.94 10.94 6 201456 8 34755461
Albumin urine present 19.87 10.94 17 201445 367 34755102
Product substitution error 19.80 10.94 7 201455 20 34755449
Palmar-plantar erythrodysaesthesia syndrome 19.73 10.94 42 201420 16753 34738716
Peptic ulcer haemorrhage 19.68 10.94 20 201442 541 34754928
Cytomegalovirus infection reactivation 19.64 10.94 3 201459 5115 34750354
Mitral valve hypoplasia 19.52 10.94 8 201454 38 34755431
Acute right ventricular failure 19.46 10.94 11 201451 117 34755352
Ventricular arrhythmia 19.39 10.94 73 201389 5455 34750014
Ear haemorrhage 19.39 10.94 26 201436 952 34754517
Pharyngeal haematoma 19.35 10.94 9 201453 61 34755408
Thrombosis 19.33 10.94 403 201059 50055 34705414
Illness 19.32 10.94 30 201432 13499 34741970
Laboratory test abnormal 19.28 10.94 57 201405 20334 34735135
Diverticulum 19.17 10.94 87 201375 7072 34748397
Product odour abnormal 19.14 10.94 23 201439 753 34754716
Viral infection 19.14 10.94 46 201416 17577 34737892
Traumatic haemothorax 19.05 10.94 15 201447 287 34755182
Erosive duodenitis 19.01 10.94 35 201427 1689 34753780
Tumour lysis syndrome 18.95 10.94 44 201418 17015 34738454
Hyperlipidaemia 18.92 10.94 146 201316 14383 34741086
Large intestine perforation 18.76 10.94 13 201449 8490 34746979
Generalised tonic-clonic seizure 18.74 10.94 61 201401 21113 34734356
Spontaneous haematoma 18.72 10.94 19 201443 513 34754956
Toxic epidermal necrolysis 18.72 10.94 63 201399 21583 34733886
Urinary bladder haemorrhage 18.65 10.94 35 201427 1714 34753755
Maternal exposure during pregnancy 18.61 10.94 3 201459 4915 34750554
Full blood count abnormal 18.52 10.94 51 201411 18617 34736852
Gastrointestinal angiectasia 18.45 10.94 15 201447 301 34755168
Arteriosclerotic gangrene 18.31 10.94 9 201453 70 34755399
Syringe issue 18.26 10.94 5 201457 5659 34749810
Benign gastrointestinal neoplasm 18.19 10.94 11 201451 134 34755335
Headache 18.17 10.94 958 200504 199677 34555792
Therapeutic response decreased 18.13 10.94 97 201365 29216 34726253
Cerebellar haematoma 18.11 10.94 13 201449 215 34755254
Implant site haematoma 18.10 10.94 9 201453 72 34755397
Myocardial necrosis marker increased 18.09 10.94 34 201428 1667 34753802
Blood creatine phosphokinase increased 18.09 10.94 361 201101 44496 34710973
Swollen tongue 18.04 10.94 145 201317 14460 34741009
Diffuse large B-cell lymphoma 18.01 10.94 10 201452 7360 34748109
Ventricular fibrillation 17.98 10.94 207 201255 22747 34732722
Mania 17.92 10.94 17 201445 9494 34745975
Staphylococcal infection 17.81 10.94 113 201349 32647 34722822
Substance abuse 17.78 10.94 11 201451 7630 34747839
Biliary cirrhosis 17.72 10.94 10 201452 106 34755363
Spinal cord haematoma 17.72 10.94 10 201452 106 34755363
Carotid artery disease 17.69 10.94 24 201438 889 34754580
Escherichia infection 17.67 10.94 13 201449 8232 34747237
Gallbladder neoplasm 17.65 10.94 7 201455 30 34755439
Aneurysm 17.64 10.94 36 201426 1876 34753593
Encephalitis 17.61 10.94 10 201452 7267 34748202
Angiodysplasia 17.58 10.94 21 201441 683 34754786
Pericardial disease 17.56 10.94 17 201445 433 34755036
Mood swings 17.54 10.94 12 201450 7889 34747580
Respiratory syncytial virus infection 17.53 10.94 3 201459 4706 34750763
Muscle rupture 17.46 10.94 40 201422 2258 34753211
Skin haemorrhage 17.44 10.94 63 201399 4615 34750854
Serum ferritin abnormal 17.42 10.94 13 201449 229 34755240
Bacterial infection 17.40 10.94 46 201416 17017 34738452
Metallosis of globe 17.37 10.94 5 201457 5 34755464
Splenic haemorrhage 17.37 10.94 17 201445 439 34755030
Thalamus haemorrhage 17.35 10.94 25 201437 980 34754489
Anastomotic infection 17.33 10.94 10 201452 111 34755358
Coronary artery embolism 17.32 10.94 11 201451 147 34755322
Anhedonia 17.29 10.94 88 201374 7497 34747972
Aortic valve stenosis 17.27 10.94 44 201418 2659 34752810
Influenza virus test positive 17.25 10.94 10 201452 112 34755357
Amaurosis fugax 17.20 10.94 19 201443 567 34754902
Mitral valve disease 17.17 10.94 30 201432 1389 34754080
Arterial disorder 17.07 10.94 28 201434 1231 34754238
No adverse event 17.04 10.94 71 201391 22856 34732613
Hypocoagulable state 17.02 10.94 24 201438 922 34754547
Colitis microscopic 17.01 10.94 40 201422 2297 34753172
Lipoprotein (a) increased 16.98 10.94 8 201454 56 34755413
Cerebral artery stenosis 16.97 10.94 15 201447 339 34755130
Nephropathy toxic 16.96 10.94 29 201433 12559 34742910
Myoglobinaemia 16.95 10.94 10 201452 116 34755353
Knee arthroplasty 16.93 10.94 11 201451 7433 34748036
Osteonecrosis 16.87 10.94 38 201424 14852 34740617
Chest wall haematoma 16.84 10.94 12 201450 196 34755273
Retinal artery occlusion 16.81 10.94 35 201427 1850 34753619
Carotid artery dissection 16.76 10.94 11 201451 156 34755313
Insulin C-peptide increased 16.75 10.94 8 201454 58 34755411
Aortic aneurysm rupture 16.70 10.94 25 201437 1015 34754454
Injection site reaction 16.68 10.94 31 201431 13002 34742467
Wound haematoma 16.63 10.94 8 201454 59 34755410
Acute respiratory distress syndrome 16.59 10.94 85 201377 25884 34729585
Prescribed underdose 16.57 10.94 98 201364 8835 34746634
Withdrawal syndrome 16.50 10.94 29 201433 12426 34743043
Arterial stent insertion 16.48 10.94 9 201453 89 34755380
Gangrene 16.45 10.94 61 201401 4525 34750944
Peptic ulcer 16.45 10.94 44 201418 2739 34752730
Ileus 16.43 10.94 45 201417 16454 34739015
Internal haemorrhage 16.40 10.94 65 201397 4976 34750493
Reocclusion 16.29 10.94 6 201456 20 34755449
Physical examination abnormal 16.22 10.94 14 201448 306 34755163
Ankylosing spondylitis 16.20 10.94 6 201456 5598 34749871
Cardiogenic shock 16.17 10.94 229 201233 26389 34729080
Neutrophil count increased 16.16 10.94 48 201414 17098 34738371
Angioedema 16.16 10.94 304 201158 37070 34718399
Haemorrhagic diathesis 16.12 10.94 44 201418 2772 34752697
Myopathy 16.11 10.94 118 201344 11436 34744033
Concomitant disease progression 16.10 10.94 41 201421 2477 34752992
Loss of consciousness 16.01 10.94 605 200857 82062 34673407
Uveitis 15.99 10.94 12 201450 7523 34747946
Herpes simplex 15.99 10.94 6 201456 5553 34749916
Seizure 15.97 10.94 471 200991 104386 34651083
Accidental exposure to product 15.90 10.94 31 201431 12771 34742698
Psoriasis 15.84 10.94 145 201317 38667 34716802
Emotional distress 15.84 10.94 144 201318 14882 34740587
Clostridium difficile infection 15.67 10.94 56 201406 18842 34736627
Hepatic steatosis 15.50 10.94 54 201408 18308 34737161
Product monitoring error 15.49 10.94 58 201404 4323 34751146
Anastomotic ulcer haemorrhage 15.45 10.94 6 201456 24 34755445
Haemoperitoneum 15.41 10.94 33 201429 1779 34753690
Haematoma muscle 15.37 10.94 28 201434 1340 34754129
Hypovolaemic shock 15.32 10.94 81 201381 7004 34748465
Arterial haemorrhage 15.32 10.94 22 201440 860 34754609
Thoracic haemorrhage 15.27 10.94 11 201451 183 34755286
Anal fistula 15.24 10.94 6 201456 5393 34750076
Eye haemorrhage 15.23 10.94 57 201405 4248 34751221
Myelodysplastic syndrome 15.22 10.94 58 201404 19150 34736319
Paranoia 15.19 10.94 29 201433 12039 34743430
Compartment syndrome 15.17 10.94 45 201417 2973 34752496
Factor V inhibition 15.12 10.94 11 201451 186 34755283
Immunosuppressant drug level increased 15.11 10.94 8 201454 6047 34749422
Type IIa hyperlipidaemia 15.07 10.94 11 201451 187 34755282
Arrhythmia 15.05 10.94 290 201172 35518 34719951
Carotid artery thrombosis 14.97 10.94 14 201448 341 34755128
Cystitis haemorrhagic 14.93 10.94 7 201455 5672 34749797
Bladder tamponade 14.93 10.94 17 201445 525 34754944
Flagellate dermatitis 14.92 10.94 8 201454 76 34755393
Platelet aggregation abnormal 14.90 10.94 6 201456 27 34755442
Haemodynamic instability 14.89 10.94 100 201362 9423 34746046
Immunosuppression 14.77 10.94 9 201453 6295 34749174
Cardiac discomfort 14.77 10.94 18 201444 598 34754871
Haemorrhage coronary artery 14.76 10.94 5 201457 12 34755457
Nerve degeneration 14.58 10.94 11 201451 197 34755272
Progressive multifocal leukoencephalopathy 14.58 10.94 21 201441 9743 34745726
Coronary ostial stenosis 14.49 10.94 8 201454 81 34755388
Oral candidiasis 14.47 10.94 30 201432 12080 34743389
Brain stem haemorrhage 14.39 10.94 22 201440 910 34754559
Gastrointestinal ulcer 14.37 10.94 31 201431 1680 34753789
Oral herpes 14.34 10.94 7 201455 5540 34749929
Intercepted product preparation error 14.33 10.94 3 201459 4075 34751394
Tuberculosis 14.29 10.94 17 201445 8560 34746909
Hypochromic anaemia 14.27 10.94 22 201440 917 34754552
Post procedural myocardial infarction 14.24 10.94 6 201456 31 34755438
Coeliac artery stenosis 14.22 10.94 5 201457 14 34755455
Congenital heart valve disorder 14.18 10.94 7 201455 55 34755414
Vessel puncture site haemorrhage 14.16 10.94 8 201454 85 34755384
Upper motor neurone lesion 14.12 10.94 9 201453 121 34755348
Brain stem infarction 14.10 10.94 26 201436 1256 34754213
Intrapericardial thrombosis 14.08 10.94 7 201455 56 34755413
Mitral valve calcification 14.06 10.94 17 201445 560 34754909
Atrioventricular block complete 14.06 10.94 97 201365 9222 34746247
Post-traumatic amnestic disorder 13.97 10.94 7 201455 57 34755412
Febrile bone marrow aplasia 13.97 10.94 16 201446 8193 34747276
Oesophagitis 13.93 10.94 127 201335 13134 34742335
Colorectal cancer 13.93 10.94 5 201457 4756 34750713
Oesophageal ulcer 13.87 10.94 47 201415 3334 34752135
Hepatitis C 13.85 10.94 22 201440 9808 34745661
Arteriovenous malformation 13.84 10.94 20 201442 786 34754683
Heart rate increased 13.80 10.94 186 201276 46157 34709312
Affective disorder 13.78 10.94 4 201458 4356 34751113
Maternal drugs affecting foetus 13.76 10.94 3 201459 3962 34751507
Migraine 13.70 10.94 53 201409 17425 34738044
Nocardiosis 13.69 10.94 3 201459 3948 34751521
Psychological trauma 13.69 10.94 11 201451 217 34755252
Drug screen positive 13.65 10.94 3 201459 3940 34751529
Medication error 13.60 10.94 215 201247 25350 34730119
Cholestatic liver injury 13.59 10.94 37 201425 2327 34753142
Brain contusion 13.53 10.94 20 201442 803 34754666
Salivary hypersecretion 13.50 10.94 18 201444 8626 34746843
Pulmonary valve disease 13.46 10.94 13 201449 330 34755139
Haematospermia 13.46 10.94 13 201449 330 34755139
Strangury 13.46 10.94 9 201453 132 34755337
Hepatitis B 13.39 10.94 9 201453 5974 34749495
Hypoxia 13.37 10.94 230 201232 54865 34700604
Bundle branch block left 13.37 10.94 69 201393 5910 34749559
Euphoric mood 13.30 10.94 8 201454 5633 34749836
Device leakage 13.29 10.94 11 201451 6564 34748905
Platelet aggregation decreased 13.28 10.94 5 201457 18 34755451
Haematoma evacuation 13.26 10.94 10 201452 179 34755290
Hyperkalaemia 13.24 10.94 507 200955 68882 34686587
Haemodilution 13.24 10.94 6 201456 38 34755431
Myocardial haemorrhage 13.24 10.94 6 201456 38 34755431
Subacute cutaneous lupus erythematosus 13.20 10.94 22 201440 980 34754489
Intra-abdominal haemorrhage 13.20 10.94 37 201425 2367 34753102
Epiglottic oedema 13.17 10.94 10 201452 181 34755288
Mucosal haemorrhage 13.15 10.94 29 201433 1596 34753873
Abnormal behaviour 13.13 10.94 87 201375 24882 34730587
Amaurosis 13.12 10.94 18 201444 674 34754795
Small intestinal obstruction 13.04 10.94 43 201419 14823 34740646
Colitis ulcerative 13.01 10.94 50 201412 16470 34738999
Supine hypertension 12.96 10.94 13 201449 346 34755123
Blindness transient 12.96 10.94 35 201427 2191 34753278
Increased tendency to bruise 12.92 10.94 52 201410 4009 34751460
Large intestine polyp 12.91 10.94 84 201378 7830 34747639
Crying 12.88 10.94 9 201453 5853 34749616
Vascular procedure complication 12.88 10.94 5 201457 20 34755449
Anal abscess 12.87 10.94 11 201451 6462 34749007
Liver function test increased 12.86 10.94 42 201420 14523 34740946
Contrast media reaction 12.77 10.94 21 201441 925 34754544
Right ventricular diastolic collapse 12.75 10.94 7 201455 70 34755399
Blue toe syndrome 12.74 10.94 9 201453 145 34755324
Acne 12.73 10.94 28 201434 11038 34744431
Poor venous access 12.72 10.94 7 201455 5176 34750293
Macular ischaemia 12.67 10.94 7 201455 71 34755398
Haemorrhagic cerebral infarction 12.67 10.94 20 201442 851 34754618
Haematocoele 12.64 10.94 4 201458 7 34755462
Arterial injury 12.64 10.94 14 201448 419 34755050
Drug level decreased 12.60 10.94 16 201446 7830 34747639
Pulmonary haemorrhage 12.57 10.94 102 201360 10202 34745267
Urethral haemorrhage 12.56 10.94 14 201448 422 34755047
Vertigo 12.56 10.94 212 201250 25324 34730145
Cardiac failure acute 12.55 10.94 104 201358 10466 34745003
Anti-insulin antibody increased 12.50 10.94 7 201455 73 34755396
Peripheral revascularisation 12.49 10.94 3 201459 0 34755469
Blood copper decreased 12.49 10.94 3 201459 0 34755469
Peripheral artery stent insertion 12.49 10.94 3 201459 0 34755469
Hypertrophy of tongue papillae 12.49 10.94 3 201459 0 34755469
Erosive oesophagitis 12.47 10.94 27 201435 1467 34754002
Kidney transplant rejection 12.34 10.94 15 201447 7482 34747987
Exercise tolerance decreased 12.34 10.94 61 201401 5137 34750332
Exposure to toxic agent 12.32 10.94 3 201459 3672 34751797
Cardiac stress test 12.30 10.94 4 201458 8 34755461
Blood uric acid increased 12.22 10.94 23 201439 9601 34745868
Neonatal respiratory distress syndrome 12.21 10.94 4 201458 4030 34751439
Skin infection 12.19 10.94 16 201446 7721 34747748
Extrapyramidal disorder 12.18 10.94 36 201426 12844 34742625
Device embolisation 12.16 10.94 5 201457 24 34755445
Thrombotic microangiopathy 12.14 10.94 27 201435 10603 34744866
Klebsiella infection 12.10 10.94 19 201443 8512 34746957
Non-cardiac chest pain 12.09 10.94 53 201409 4244 34751225
Arterial bypass operation 12.07 10.94 6 201456 48 34755421
Lacunar stroke 12.04 10.94 10 201452 207 34755262
Enterococcal infection 12.03 10.94 22 201440 9284 34746185
Stent malfunction 12.00 10.94 5 201457 25 34755444
Cerebrovascular disorder 12.00 10.94 30 201432 1792 34753677
Urinary tract infection 11.98 10.94 381 201081 83700 34671769
Pericardial fibrosis 11.98 10.94 8 201454 117 34755352
Cardiac death 11.96 10.94 22 201440 1061 34754408
Hypothyroidism 11.93 10.94 71 201391 20831 34734638
Body temperature decreased 11.92 10.94 37 201425 12997 34742472
Alcohol poisoning 11.91 10.94 3 201459 3590 34751879
Rectal ulcer 11.86 10.94 21 201441 983 34754486
Thrombotic stroke 11.83 10.94 11 201451 266 34755203
Monoparesis 11.81 10.94 35 201427 2311 34753158
Varicose vein 11.80 10.94 25 201437 1338 34754131
Bundle branch block right 11.79 10.94 79 201383 7437 34748032
Vitamin B complex deficiency 11.74 10.94 13 201449 389 34755080
Haemorrhagic cyst 11.74 10.94 7 201455 83 34755386
Consciousness fluctuating 11.73 10.94 23 201439 1164 34754305
Carotid artery stent insertion 11.70 10.94 4 201458 10 34755459
Blood pressure orthostatic abnormal 11.66 10.94 7 201455 84 34755385
Oedema peripheral 11.66 10.94 821 200641 118991 34636478
Metastases to liver 11.65 10.94 40 201422 13623 34741846
Needle issue 11.63 10.94 11 201451 6154 34749315
Obsessive-compulsive disorder 11.63 10.94 9 201453 5555 34749914
Conjunctivitis 11.63 10.94 24 201438 9681 34745788
Diverticulum intestinal 11.63 10.94 50 201412 3971 34751498
Exostosis 11.62 10.94 56 201406 4667 34750802
Atrioventricular block 11.62 10.94 83 201379 7980 34747489
Toxic encephalopathy 11.61 10.94 8 201454 5241 34750228
Rales 11.61 10.94 97 201365 9786 34745683
Diffuse vasculitis 11.59 10.94 7 201455 85 34755384
Congenital aortic anomaly 11.59 10.94 7 201455 85 34755384
Peripheral venous disease 11.59 10.94 38 201424 2650 34752819
Cerebellar ischaemia 11.53 10.94 8 201454 125 34755344
Clostridium difficile colitis 11.51 10.94 49 201413 15681 34739788
Herpes zoster cutaneous disseminated 11.48 10.94 9 201453 171 34755298
Muscle injury 11.47 10.94 26 201436 1457 34754012
Acute hepatic failure 11.47 10.94 42 201420 14032 34741437
Tenosynovitis 11.46 10.94 6 201456 4564 34750905
Impaired quality of life 11.43 10.94 10 201452 5808 34749661
Pseudomonas infection 11.43 10.94 35 201427 12347 34743122
Implantable defibrillator insertion 11.38 10.94 18 201444 767 34754702
Mydriasis 11.37 10.94 15 201447 7222 34748247
Tongue haematoma 11.37 10.94 8 201454 128 34755341
Cognitive disorder 11.36 10.94 108 201354 28585 34726884
Immunodeficiency 11.36 10.94 9 201453 5489 34749980
Nasal congestion 11.30 10.94 82 201380 22975 34732494
Osteitis deformans 11.25 10.94 5 201457 30 34755439
Meningitis 11.25 10.94 7 201455 4840 34750629
Hepatotoxicity 11.23 10.94 75 201387 21410 34734059
Gastric polyps 11.21 10.94 23 201439 1203 34754266
Peripheral artery restenosis 11.17 10.94 4 201458 12 34755457
Renal injury 11.15 10.94 106 201356 11089 34744380
Aortic aneurysm 11.09 10.94 72 201390 6707 34748762
Mineral supplementation 11.06 10.94 7 201455 93 34755376
Catheter site haemorrhage 11.03 10.94 33 201429 2191 34753278
Cardioactive drug level increased 11.02 10.94 28 201434 1689 34753780
Graft thrombosis 10.96 10.94 11 201451 293 34755176
Brain herniation 10.95 10.94 49 201413 3959 34751510

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 3889.73 9.91 4158 306101 179971 79254158
Acute myocardial infarction 2401.44 9.91 2155 308104 74881 79359248
Gastrointestinal haemorrhage 2256.37 9.91 2825 307434 144894 79289235
Coronary artery disease 1825.06 9.91 1721 308538 63753 79370376
Melaena 1456.31 9.91 1472 308787 59418 79374711
Cerebrovascular accident 1278.77 9.91 2221 308038 153071 79281058
Labelled drug-drug interaction medication error 1195.47 9.91 935 309324 26715 79407414
Coronary arterial stent insertion 1058.48 9.91 502 309757 5542 79428587
Anaemia 1009.29 9.91 3904 306355 441111 78993018
Vascular stent thrombosis 936.77 9.91 398 309861 3312 79430817
Angina pectoris 926.90 9.91 1074 309185 50658 79383471
Cerebral haemorrhage 816.00 9.91 1063 309196 56610 79377519
Cardiac failure congestive 808.73 9.91 1741 308518 140661 79293468
Upper gastrointestinal haemorrhage 742.76 9.91 860 309399 40520 79393609
Haematoma 685.98 9.91 928 309331 51267 79382862
Subdural haematoma 684.61 9.91 723 309536 30711 79403418
Haematochezia 667.22 9.91 1212 309047 86433 79347696
Haematemesis 663.85 9.91 914 309345 51350 79382779
Haemorrhage 650.93 9.91 1226 309033 89892 79344237
Drug interaction 650.26 9.91 3262 306997 411921 79022208
Angina unstable 646.26 9.91 527 309732 16000 79418129
Drug ineffective 612.46 9.91 2161 308098 1078752 78355377
Off label use 606.49 9.91 1682 308577 905533 78528596
Thrombosis in device 605.88 9.91 333 309926 5109 79429020
Rectal haemorrhage 601.02 9.91 1071 309188 75229 79358900
Haematuria 575.60 9.91 992 309267 67844 79366285
Acute coronary syndrome 558.92 9.91 540 309719 20593 79413536
Synovitis 516.99 9.91 15 310244 150719 79283410
Chest pain 497.65 9.91 2296 307963 280008 79154121
Coronary artery occlusion 491.55 9.91 436 309823 14879 79419250
Infusion related reaction 476.83 9.91 151 310108 230086 79204043
Drug intolerance 472.65 9.91 218 310041 263901 79170228
Toxicity to various agents 470.58 9.91 569 309690 420971 79013158
Coronary artery stenosis 464.93 9.91 387 309872 12097 79422032
Gastric haemorrhage 464.32 9.91 419 309840 14631 79419498
Transient ischaemic attack 458.45 9.91 773 309486 51922 79382207
Haemorrhage intracranial 447.72 9.91 531 309728 25662 79408467
Rhabdomyolysis 406.33 9.91 1095 309164 102036 79332093
Drug abuse 377.80 9.91 85 310174 162606 79271523
Treatment failure 370.84 9.91 102 310157 170384 79263745
Epistaxis 362.62 9.91 1105 309154 110410 79323719
Maternal exposure during pregnancy 356.43 9.91 53 310206 136485 79297644
Hand deformity 353.92 9.91 11 310248 103908 79330221
Lower gastrointestinal haemorrhage 349.47 9.91 370 309889 15755 79418374
Alopecia 347.57 9.91 237 310022 231118 79203011
Systemic lupus erythematosus 345.65 9.91 35 310224 121114 79313015
Joint swelling 338.71 9.91 374 309885 288272 79145857
Cerebral infarction 337.77 9.91 624 309635 45052 79389077
Rheumatoid arthritis 334.49 9.91 198 310061 208272 79225857
Febrile neutropenia 333.40 9.91 247 310012 230752 79203377
Therapeutic product effect decreased 331.20 9.91 112 310147 163751 79270378
Syncope 328.87 9.91 1477 308782 177972 79256157
Completed suicide 312.64 9.91 297 309962 245470 79188659
Pemphigus 311.37 9.91 19 310240 99563 79334566
Vascular pseudoaneurysm 308.24 9.91 184 310075 3326 79430803
Vascular stent stenosis 298.89 9.91 137 310122 1390 79432739
Shock haemorrhagic 298.10 9.91 379 309880 19681 79414448
Arthralgia 288.75 9.91 1195 309064 570608 78863521
Blood loss anaemia 286.26 9.91 327 309932 15171 79418958
Pyrexia 280.94 9.91 1524 308735 677185 78756944
Coronary artery thrombosis 278.44 9.91 165 310094 2941 79431188
Arthropathy 276.03 9.91 174 310085 176937 79257192
Pericarditis 266.27 9.91 43 310216 104193 79329936
Haemoglobin decreased 261.84 9.91 1618 308641 220501 79213628
Ischaemic stroke 260.67 9.91 465 309794 32666 79401463
Coronary artery restenosis 256.26 9.91 118 310141 1211 79432918
Pain 255.91 9.91 1647 308612 702155 78731974
Haemoptysis 254.96 9.91 628 309631 55371 79378758
Glossodynia 254.37 9.91 47 310212 103290 79330839
Stent placement 252.97 9.91 207 310052 6313 79427816
Myocardial ischaemia 249.88 9.91 395 309864 25124 79409005
Coronary artery bypass 249.04 9.91 199 310060 5863 79428266
Therapeutic product effect incomplete 242.43 9.91 124 310135 141521 79292608
Sinusitis 235.12 9.91 248 310011 195253 79238876
Subarachnoid haemorrhage 233.10 9.91 374 309885 24091 79410038
Acute kidney injury 232.20 9.91 3060 307199 516344 78917785
Nasopharyngitis 227.64 9.91 399 309860 253482 79180647
Multiple injuries 226.14 9.91 151 310108 3344 79430785
Product use issue 225.62 9.91 291 309968 209531 79224598
Exposure during pregnancy 222.70 9.91 59 310200 101073 79333056
Infection 218.41 9.91 378 309881 241334 79192795
Carotid artery stenosis 211.50 9.91 213 310046 8545 79425584
Post procedural haemorrhage 211.09 9.91 264 309995 13480 79420649
Cardiac failure 207.58 9.91 1167 309092 153675 79280454
Duodenal ulcer perforation 202.93 9.91 14 310245 66197 79367932
Thrombotic thrombocytopenic purpura 199.60 9.91 179 310080 6197 79427932
Fall 199.52 9.91 2828 307431 484801 78949328
Product use in unapproved indication 198.73 9.91 423 309836 249936 79184193
Hemiparesis 194.13 9.91 415 309844 33318 79400811
Hypoglycaemia 194.13 9.91 847 309412 100747 79333382
Faeces discoloured 190.79 9.91 378 309881 28749 79405380
Musculoskeletal stiffness 184.76 9.91 246 310013 174762 79259367
Hypersensitivity 182.62 9.91 475 309784 261764 79172365
Drug hypersensitivity 180.72 9.91 579 309680 298337 79135792
Hepatic enzyme increased 180.53 9.91 269 309990 182341 79251788
Cerebral haematoma 178.81 9.91 186 310073 7756 79426373
Retroperitoneal haematoma 176.37 9.91 154 310105 5143 79428986
Gastritis erosive 174.06 9.91 213 310046 10634 79423495
Folliculitis 171.81 9.91 11 310248 55369 79378760
Spinal epidural haematoma 171.56 9.91 92 310167 1340 79432789
Hypotension 171.44 9.91 2532 307727 437785 78996344
Weight increased 169.98 9.91 534 309725 276852 79157277
Arteriosclerosis 165.98 9.91 273 309986 17954 79416175
Ecchymosis 165.21 9.91 247 310012 14959 79419170
Helicobacter infection 164.62 9.91 35 310224 69669 79364460
Retroperitoneal haemorrhage 164.23 9.91 150 310109 5320 79428809
Abdominal discomfort 163.44 9.91 469 309790 250258 79183871
Intentional product use issue 163.44 9.91 211 310048 151901 79282228
Disease progression 163.16 9.91 292 309967 184070 79250059
Stomatitis 162.45 9.91 199 310060 146558 79287571
Product administration error 160.98 9.91 372 309887 31474 79402655
Ischaemic cardiomyopathy 158.69 9.91 172 310087 7523 79426606
Rash 158.34 9.91 1463 308796 576895 78857234
Swelling 158.26 9.91 383 309876 216328 79217801
Discomfort 158.23 9.91 153 310106 125464 79308665
Peripheral arterial occlusive disease 157.19 9.91 177 310082 8081 79426048
Intraventricular haemorrhage 154.57 9.91 138 310121 4749 79429380
Duodenal ulcer 152.89 9.91 248 310011 16121 79418008
Insulin autoimmune syndrome 152.63 9.91 59 310200 373 79433756
Psoriatic arthropathy 151.25 9.91 57 310202 77942 79356187
Cardiac disorder 150.73 9.91 580 309679 65177 79368952
Haemorrhagic stroke 150.55 9.91 200 310059 10846 79423283
Sleep disorder due to general medical condition, insomnia type 150.52 9.91 4 310255 43552 79390577
Hyperkalaemia 149.84 9.91 857 309402 113541 79320588
International normalised ratio increased 145.15 9.91 684 309575 84037 79350092
Duodenal ulcer haemorrhage 140.58 9.91 156 310103 7007 79427122
Irritable bowel syndrome 139.53 9.91 35 310224 62206 79371923
Diverticulum intestinal haemorrhagic 138.37 9.91 119 310140 3892 79430237
Bradycardia 136.76 9.91 950 309309 134607 79299522
Dizziness 136.13 9.91 2836 307423 523605 78910524
C-reactive protein abnormal 135.29 9.91 15 310244 48352 79385777
Extradural haematoma 134.62 9.91 102 310157 2774 79431355
Post procedural haematoma 133.25 9.91 95 310164 2347 79431782
Mitral valve incompetence 129.63 9.91 320 309939 28245 79405884
Lower respiratory tract infection 128.03 9.91 190 310069 129030 79305099
Malignant neoplasm progression 127.07 9.91 208 310051 135782 79298347
Abdominal wall haematoma 125.97 9.91 123 310136 4750 79429379
Intermittent claudication 125.92 9.91 106 310153 3365 79430764
Muscle haemorrhage 125.01 9.91 138 310121 6162 79427967
Subdural haemorrhage 124.49 9.91 134 310125 5814 79428315
Gastric ulcer 122.54 9.91 349 309910 33556 79400573
Respiratory tract haemorrhage 120.94 9.91 80 310179 1743 79432386
Atrial fibrillation 120.77 9.91 1239 309020 196647 79237482
Loss of personal independence in daily activities 120.07 9.91 133 310126 102447 79331682
Arterial occlusive disease 119.72 9.91 156 310103 8300 79425829
Asthenia 119.30 9.91 2716 307543 508973 78925156
White blood cell count decreased 118.46 9.91 358 309901 187930 79246199
Cardiac tamponade 115.87 9.91 161 310098 9115 79425014
Pallor 115.08 9.91 442 309817 49620 79384509
COVID-19 114.03 9.91 280 309979 157394 79276735
Neutropenia 113.18 9.91 656 309603 287054 79147075
Pulmonary alveolar haemorrhage 111.68 9.91 177 310082 11280 79422849
Arterial haemorrhage 111.50 9.91 87 310172 2474 79431655
Presyncope 110.89 9.91 382 309877 40672 79393457
Headache 110.55 9.91 1834 308425 651938 78782191
Contraindicated product administered 106.82 9.91 289 309970 157249 79276880
Injection site pain 106.63 9.91 215 310044 129623 79304506
Fatigue 105.73 9.91 2783 307476 926944 78507185
Muscle injury 105.63 9.91 29 310230 48532 79385597
Cytokine release syndrome 103.69 9.91 10 310249 35988 79398141
Peripheral swelling 101.68 9.91 623 309636 268994 79165135
Arteriosclerosis coronary artery 101.14 9.91 218 310041 17598 79416531
Pericardial haemorrhage 100.70 9.91 105 310154 4390 79429739
Angioplasty 100.56 9.91 72 310187 1791 79432338
Splenic rupture 100.34 9.91 80 310179 2349 79431780
Arterial stenosis 100.10 9.91 65 310194 1371 79432758
Coronary angioplasty 99.95 9.91 43 310216 370 79433759
Iron deficiency anaemia 98.43 9.91 270 309989 25402 79408727
Hip arthroplasty 97.74 9.91 12 310247 35744 79398385
Injection site erythema 97.58 9.91 96 310163 78101 79356028
Abortion spontaneous 97.39 9.91 4 310255 29503 79404626
Microcytic anaemia 96.92 9.91 111 310148 5163 79428966
Knee arthroplasty 95.63 9.91 25 310234 43223 79390906
Peripheral artery stenosis 95.48 9.91 61 310198 1250 79432879
Condition aggravated 94.71 9.91 1376 308883 499748 78934381
Procedural haemorrhage 93.23 9.91 103 310156 4603 79429526
Product prescribing error 92.83 9.91 383 309876 44430 79389699
Renal failure 92.37 9.91 1191 309068 199777 79234352
Electrocardiogram ST segment elevation 92.08 9.91 137 310122 8260 79425869
Occult blood positive 91.31 9.91 123 310136 6760 79427369
Aphasia 91.05 9.91 392 309867 46340 79387789
Gastritis 90.01 9.91 398 309861 47595 79386534
Troponin increased 89.80 9.91 218 310041 19037 79415092
Dyspnoea 89.19 9.91 4130 306129 852895 78581234
Hemiplegia 88.50 9.91 186 310073 14753 79419376
Gastrointestinal disorder 87.57 9.91 218 310041 121987 79312142
Haemorrhagic transformation stroke 87.09 9.91 77 310182 2615 79431514
Ill-defined disorder 86.75 9.91 77 310182 65798 79368331
Wound 85.81 9.91 204 310055 115975 79318154
Cardiogenic shock 85.07 9.91 356 309903 41558 79392571
Intentional overdose 84.85 9.91 178 310081 105782 79328347
Asthma 84.85 9.91 257 310002 134838 79299291
Gastric ulcer haemorrhage 84.62 9.91 137 310122 8890 79425239
Pregnancy 84.29 9.91 5 310254 26846 79407283
Ventricular tachycardia 84.20 9.91 355 309904 41580 79392549
Intestinal haemorrhage 83.98 9.91 114 310145 6312 79427817
Blood creatine phosphokinase increased 83.82 9.91 491 309768 65599 79368530
Peripheral vascular disorder 82.36 9.91 127 310132 7903 79426226
Injection site reaction 82.34 9.91 56 310203 54729 79379400
Cytomegalovirus infection 81.28 9.91 32 310227 42612 79391517
Myalgia 80.65 9.91 1089 309170 184552 79249577
Chronic kidney disease 80.39 9.91 486 309773 65668 79368461
Coronary artery dissection 80.28 9.91 52 310207 1092 79433037
Fibromyalgia 80.26 9.91 79 310180 64261 79369868
Myelosuppression 78.87 9.91 29 310230 40267 79393862
C-reactive protein increased 78.52 9.91 249 310010 128778 79305351
Haemobilia 77.86 9.91 39 310220 489 79433640
Cardiac arrest 77.85 9.91 1017 309242 171079 79263050
Spinal cord haemorrhage 77.65 9.91 40 310219 534 79433595
Heparin-induced thrombocytopenia 77.57 9.91 137 310122 9545 79424584
Coronary artery perforation 77.29 9.91 24 310235 68 79434061
Nausea 76.54 9.91 2999 307260 954197 78479932
Vascular graft 75.70 9.91 63 310196 1968 79432161
Mallory-Weiss syndrome 75.62 9.91 73 310186 2779 79431350
Bleeding time prolonged 74.93 9.91 52 310207 1229 79432900
Duodenitis 74.80 9.91 121 310138 7846 79426283
Percutaneous coronary intervention 74.77 9.91 35 310224 374 79433755
Peripheral ischaemia 74.72 9.91 133 310126 9324 79424805
Diarrhoea 73.82 9.91 2743 307516 877746 78556383
Ejection fraction decreased 72.78 9.91 297 309962 34280 79399849
Haemarthrosis 72.78 9.91 101 310158 5711 79428418
Impaired healing 72.09 9.91 145 310114 87510 79346619
Device occlusion 71.77 9.91 149 310110 11717 79422412
Haemorrhage subcutaneous 71.66 9.91 91 310168 4718 79429411
Dermatitis exfoliative 71.47 9.91 141 310118 10688 79423441
Ventricular hypokinesia 71.39 9.91 129 310130 9150 79424979
Haemothorax 71.32 9.91 97 310162 5381 79428748
Drug dependence 70.75 9.91 35 310224 40734 79393395
Herpes zoster 70.70 9.91 161 310098 92922 79341207
Gingival bleeding 70.35 9.91 179 310080 16097 79418032
Spontaneous haematoma 70.05 9.91 52 310207 1370 79432759
Device expulsion 69.90 9.91 9 310250 25852 79408277
Sedation 69.13 9.91 60 310199 51835 79382294
Head injury 68.64 9.91 308 309951 37061 79397068
Cardiovascular disorder 68.53 9.91 189 310070 17836 79416293
Vascular stent occlusion 67.71 9.91 28 310231 216 79433913
Intentional product misuse 66.45 9.91 172 310087 94993 79339136
Lactic acidosis 66.22 9.91 485 309774 69874 79364255
Neoplasm progression 66.16 9.91 62 310197 51620 79382509
Hyphaema 65.68 9.91 42 310217 862 79433267
Product dose omission issue 65.45 9.91 631 309628 246906 79187223
Cardiac aneurysm 64.86 9.91 51 310208 1467 79432662
Conjunctival haemorrhage 64.76 9.91 96 310163 5769 79428360
Embolic stroke 64.34 9.91 112 310147 7714 79426415
Arthritis 64.23 9.91 230 310029 114650 79319479
Intentional self-injury 64.01 9.91 23 310236 32396 79401733
Neuropathy peripheral 63.99 9.91 307 309952 140998 79293131
Ventricular fibrillation 63.88 9.91 270 309989 31656 79402473
Kounis syndrome 63.76 9.91 81 310178 4201 79429928
Blood creatine phosphokinase MB increased 63.58 9.91 66 310193 2745 79431384
Internal haemorrhage 63.18 9.91 119 310140 8714 79425415
Gastrointestinal vascular malformation haemorrhagic 63.07 9.91 39 310220 753 79433376
Carotid arteriosclerosis 63.04 9.91 64 310195 2592 79431537
Blister 63.01 9.91 245 310014 119231 79314898
Circulatory collapse 62.95 9.91 302 309957 37366 79396763
Suicide attempt 62.54 9.91 144 310115 82788 79351341
Gastrointestinal tract mucosal pigmentation 62.30 9.91 43 310216 1007 79433122
Loss of consciousness 62.13 9.91 958 309301 166985 79267144
Inappropriate schedule of product administration 61.87 9.91 288 309971 133340 79300789
Cerebellar haemorrhage 61.49 9.91 66 310193 2854 79431275
Lymphocyte count decreased 61.40 9.91 56 310203 47233 79386896
Puncture site haemorrhage 61.30 9.91 35 310224 580 79433549
Oropharyngeal pain 61.09 9.91 219 310040 109134 79324995
Neurotoxicity 61.00 9.91 25 310234 32493 79401636
Unmasking of previously unidentified disease 60.96 9.91 56 310203 2001 79432128
Hyponatraemia 60.72 9.91 1001 309258 176847 79257282
Migraine 60.42 9.91 159 310100 87334 79346795
Angiopathy 60.38 9.91 103 310156 6979 79427150
Live birth 60.36 9.91 3 310256 18741 79415388
Insomnia 60.25 9.91 636 309623 244534 79189595
Osteoporosis 59.19 9.91 74 310185 54038 79380091
Traumatic haematoma 58.59 9.91 55 310204 2021 79432108
Posterior reversible encephalopathy syndrome 58.47 9.91 15 310244 26266 79407863
Drug ineffective for unapproved indication 58.24 9.91 68 310191 51170 79382959
Electrocardiogram Q wave abnormal 57.87 9.91 34 310225 596 79433533
Small intestinal haemorrhage 57.69 9.91 76 310183 4087 79430042
Intracardiac thrombus 57.38 9.91 77 310182 4216 79429913
Influenza 57.29 9.91 284 309975 129322 79304807
Tricuspid valve incompetence 57.28 9.91 188 310071 19524 79414605
Spontaneous haemorrhage 57.00 9.91 37 310222 780 79433349
Hepatojugular reflux 56.98 9.91 34 310225 614 79433515
Therapy non-responder 56.95 9.91 177 310082 92128 79342001
Ischaemia 56.78 9.91 108 310151 7967 79426162
Lacunar infarction 56.65 9.91 91 310168 5866 79428263
Petechiae 56.09 9.91 192 310067 20373 79413756
Neutrophil count decreased 55.99 9.91 183 310076 93776 79340353
Vascular graft occlusion 55.83 9.91 35 310224 693 79433436
Dysarthria 55.76 9.91 452 309807 67170 79366959
Immunodeficiency 55.53 9.91 9 310250 21759 79412370
Coagulation time prolonged 55.39 9.91 58 310201 2437 79431692
Brain herniation 55.20 9.91 102 310157 7361 79426768
Occult blood 55.18 9.91 49 310210 1674 79432455
Overdose 55.07 9.91 455 309804 183751 79250378
Mobility decreased 54.99 9.91 266 309993 121909 79312220
Gastrointestinal angiodysplasia 54.70 9.91 40 310219 1029 79433100
Angiocardiogram 54.38 9.91 24 310235 221 79433908
Red blood cell sedimentation rate increased 54.37 9.91 59 310200 45883 79388246
Thrombosis 54.34 9.91 533 309726 83567 79350562
Cerebral hyperperfusion syndrome 53.76 9.91 20 310239 112 79434017
Hiatus hernia 53.71 9.91 206 310053 23106 79411023
Ocular retrobulbar haemorrhage 53.26 9.91 21 310238 141 79433988
Angioedema 53.16 9.91 490 309769 75545 79358584
Adverse drug reaction 52.75 9.91 112 310147 66280 79367849
Multiple sclerosis relapse 52.63 9.91 62 310197 46471 79387658
Peripheral artery occlusion 52.45 9.91 57 310202 2500 79431629
Therapy partial responder 52.38 9.91 4 310255 17393 79416736
Atrioventricular block 52.17 9.91 146 310113 13895 79420234
Therapeutic response decreased 52.10 9.91 114 310145 66739 79367390
Cardiac failure chronic 51.85 9.91 126 310133 11009 79423120
Intra-abdominal haematoma 51.70 9.91 60 310199 2831 79431298
Mucosal inflammation 51.70 9.91 138 310121 75442 79358687
N-terminal prohormone brain natriuretic peptide increased 51.31 9.91 77 310182 4678 79429451
Flushing 51.17 9.91 174 310085 88094 79346035
Oesophageal intramural haematoma 51.13 9.91 19 310240 106 79434023
Cerebral mass effect 50.94 9.91 49 310210 1857 79432272
Serotonin syndrome 50.92 9.91 60 310199 44967 79389162
Pneumonia 50.80 9.91 2077 308182 658169 78775960
Blood pressure decreased 50.62 9.91 601 309658 98865 79335264
Psoriasis 50.31 9.91 179 310080 89408 79344721
Pulmonary haematoma 49.98 9.91 19 310240 114 79434015
Spinal subarachnoid haemorrhage 49.90 9.91 16 310243 52 79434077
Poisoning deliberate 49.82 9.91 7 310252 18821 79415308
Wheezing 49.65 9.91 259 310000 116405 79317724
Coagulation time abnormal 49.53 9.91 22 310237 206 79433923
Catheter site haematoma 49.39 9.91 26 310233 364 79433765
Helicobacter gastritis 49.21 9.91 54 310205 2395 79431734
Suicidal ideation 48.80 9.91 144 310115 76196 79357933
Injection site pruritus 48.18 9.91 56 310203 42227 79391902
Arterial restenosis 47.95 9.91 16 310243 61 79434068
Gastritis haemorrhagic 47.28 9.91 55 310204 2602 79431527
Mediastinal haematoma 47.15 9.91 21 310238 198 79433931
Orthostatic hypotension 46.62 9.91 376 309883 55788 79378341
Mouth haemorrhage 46.21 9.91 119 310140 10780 79423349
Acute pulmonary oedema 46.19 9.91 141 310118 14089 79420040
Dystonia 46.12 9.91 13 310246 21386 79412743
Dyspnoea exertional 46.03 9.91 530 309729 86543 79347586
Neuroleptic malignant syndrome 45.83 9.91 25 310234 27534 79406595
Platelet function test abnormal 45.81 9.91 20 310239 179 79433950
Wound haemorrhage 45.79 9.91 68 310191 4093 79430036
Dyspnoea at rest 45.70 9.91 93 310166 7209 79426920
Degenerative mitral valve disease 45.67 9.91 23 310236 292 79433837
Hyperlipidaemia 45.64 9.91 212 310047 25881 79408248
Coronary artery reocclusion 45.57 9.91 19 310240 150 79433979
Haematotoxicity 45.53 9.91 4 310255 15515 79418614
Inferior vena cava dilatation 45.50 9.91 33 310226 838 79433291
Aortic aneurysm 45.28 9.91 101 310158 8345 79425784
Acquired haemophilia 45.27 9.91 46 310213 1865 79432264
Gastrointestinal polyp haemorrhage 45.23 9.91 27 310232 488 79433641
Acne 44.73 9.91 25 310234 27165 79406964
Systolic dysfunction 44.63 9.91 64 310195 3731 79430398
Upper respiratory tract infection 44.29 9.91 193 310066 90975 79343154
Myocardial rupture 44.09 9.91 21 310238 234 79433895
Diverticulum intestinal 44.01 9.91 101 310158 8504 79425625
Atheroembolism 43.75 9.91 23 310236 321 79433808
Infective exacerbation of chronic obstructive airways disease 43.59 9.91 54 310205 2730 79431399
Haemorrhagic cholecystitis 43.39 9.91 16 310243 87 79434042
Bone marrow failure 43.35 9.91 83 310176 51024 79383105
Oedema peripheral 42.85 9.91 1285 308974 251003 79183126
Rheumatoid nodule 42.75 9.91 8 310251 17430 79416699
Ischaemic cerebral infarction 42.66 9.91 51 310208 2484 79431645
Injection site swelling 42.24 9.91 74 310185 47058 79387071
Haemorrhage urinary tract 42.22 9.91 50 310209 2411 79431718
Electrocardiogram ST segment depression 41.66 9.91 71 310188 4807 79429322
Haemorrhagic arteriovenous malformation 41.64 9.91 27 310232 568 79433561
Pharyngeal haematoma 41.35 9.91 17 310242 129 79434000
Haemorrhagic ascites 41.33 9.91 21 310238 272 79433857
Pathogen resistance 41.26 9.91 4 310255 14338 79419791
Cerebral ischaemia 41.19 9.91 116 310143 11079 79423050
Red blood cell sedimentation rate abnormal 41.17 9.91 15 310244 20948 79413181
Adverse event 41.14 9.91 110 310149 60104 79374025
Illness 40.81 9.91 74 310185 46437 79387692
Acute myeloid leukaemia 40.78 9.91 36 310223 30849 79403280
Aortic valve incompetence 40.35 9.91 104 310155 9426 79424703
Sepsis 40.23 9.91 772 309487 268656 79165473
Pituitary haemorrhage 40.14 9.91 21 310238 290 79433839
Inflammation 39.97 9.91 208 310051 93545 79340584
Liver function test increased 39.84 9.91 58 310201 39715 79394414
Foot deformity 39.80 9.91 22 310237 24052 79410077
Fungal infection 39.78 9.91 63 310196 41685 79392444
Nasal congestion 39.71 9.91 158 310101 76394 79357735
Normocytic anaemia 39.64 9.91 64 310195 4143 79429986
Infarction 39.54 9.91 67 310192 4515 79429614
Splenic haematoma 39.39 9.91 21 310238 302 79433827
Carotid artery occlusion 39.38 9.91 90 310169 7557 79426572
Oesophagitis 39.34 9.91 193 310066 24096 79410033
Atrioventricular block complete 39.27 9.91 148 310111 16462 79417667
Pancytopenia 38.68 9.91 435 309824 165310 79268819
Skin candida 38.48 9.91 44 310215 2043 79432086
Vessel puncture site haematoma 38.32 9.91 18 310241 194 79433935
Subarachnoid haematoma 38.31 9.91 20 310239 275 79433854
Fat embolism 38.08 9.91 23 310236 425 79433704
Stenosis 37.95 9.91 47 310212 2375 79431754
Urogenital haemorrhage 37.86 9.91 31 310228 946 79433183
Atrial thrombosis 37.75 9.91 58 310201 3598 79430531
Facial paralysis 37.44 9.91 172 310087 20900 79413229
Mesenteric artery thrombosis 37.41 9.91 26 310233 616 79433513
Renal haemorrhage 37.33 9.91 45 310214 2211 79431918
Sleep disorder 37.13 9.91 189 310070 85488 79348641
Vitreous haemorrhage 37.07 9.91 58 310201 3655 79430474
Renal injury 36.90 9.91 147 310112 16780 79417349
Pemphigoid 36.66 9.91 137 310122 15178 79418951
Page kidney 36.65 9.91 13 310246 62 79434067
Aortic arteriosclerosis 36.40 9.91 96 310163 8822 79425307
Aortic valve stenosis 36.24 9.91 70 310189 5224 79428905
Eosinophilic bronchitis 36.10 9.91 23 310236 469 79433660
Arrhythmia 36.07 9.91 381 309878 60891 79373238
Bladder sphincter atony 36.02 9.91 15 310244 118 79434011
Chronic obstructive pulmonary disease 35.80 9.91 498 309761 84921 79349208
Encephalopathy 35.66 9.91 138 310121 67259 79366870
Haemoperitoneum 35.50 9.91 62 310197 4281 79429848
Cardiac ventricular thrombosis 35.46 9.91 39 310220 1734 79432395
Diverticulum 35.44 9.91 133 310126 14763 79419366
Device related infection 35.35 9.91 49 310210 34245 79399884
Tachycardia 35.29 9.91 483 309776 177285 79256844
Skin flap necrosis 35.21 9.91 11 310248 32 79434097
Eosinophilia 35.19 9.91 299 309960 45046 79389083
Aortic stenosis 35.10 9.91 85 310174 7410 79426719
Arterial intramural haematoma 34.77 9.91 13 310246 74 79434055
Immune reconstitution inflammatory syndrome 34.69 9.91 6 310253 13835 79420294
Cytopenia 34.62 9.91 18 310241 20365 79413764
Haemophagocytic lymphohistiocytosis 34.62 9.91 21 310238 21816 79412313
Subcutaneous haematoma 34.39 9.91 48 310211 2729 79431400
Bursitis 34.24 9.91 54 310205 35790 79398339
Post procedural complication 34.16 9.91 183 310076 23646 79410483
Quadriparesis 34.00 9.91 54 310205 3447 79430682
Premature delivery 33.93 9.91 25 310234 23442 79410687
Lip dry 33.92 9.91 9 310250 15409 79418720
Pulmonary haemorrhage 33.86 9.91 130 310129 14587 79419542
Labile hypertension 33.80 9.91 23 310236 526 79433603
Gynaecomastia 33.74 9.91 85 310174 7596 79426533
Pulmonary vascular disorder 33.58 9.91 30 310229 1033 79433096
Drug withdrawal syndrome 33.45 9.91 52 310207 34666 79399463
Normochromic normocytic anaemia 33.41 9.91 85 310174 7642 79426487
Endothelial dysfunction 33.33 9.91 17 310242 222 79433907
Transplant rejection 33.26 9.91 17 310242 19420 79414709
Bronchopulmonary aspergillosis 33.22 9.91 23 310236 22271 79411858
Incision site haemorrhage 33.03 9.91 30 310229 1056 79433073
Bundle branch block left 32.73 9.91 109 310150 11404 79422725
Tachyarrhythmia 32.65 9.91 79 310180 6883 79427246
Intracranial haematoma 32.65 9.91 28 310231 912 79433217
Joint stiffness 32.33 9.91 69 310190 40761 79393368
Myoglobinaemia 32.29 9.91 14 310245 123 79434006
Cardiac death 32.14 9.91 35 310224 1539 79432590
Blood glucose increased 32.09 9.91 627 309632 114348 79319781
Grip strength decreased 32.00 9.91 23 310236 21846 79412283
Pneumocystis jirovecii pneumonia 31.98 9.91 48 310211 32460 79401669
Renal impairment 31.93 9.91 822 309437 156961 79277168
Panniculitis 31.81 9.91 5 310254 12366 79421763
Laryngeal haemorrhage 31.80 9.91 11 310248 48 79434081
Drug tolerance decreased 31.72 9.91 6 310253 12972 79421157
Obesity 31.61 9.91 55 310204 35070 79399059
Cardiac operation 31.57 9.91 64 310195 4948 79429181
Large intestine polyp 31.52 9.91 115 310144 12593 79421536
Cytomegalovirus viraemia 31.18 9.91 6 310253 12815 79421314
Hypomagnesaemia 31.13 9.91 299 309960 46612 79387517
Large intestinal haemorrhage 31.09 9.91 46 310213 2759 79431370
Pulmonary embolism 31.05 9.91 475 309784 171179 79262950
Eye haemorrhage 31.03 9.91 96 310163 9661 79424468
Haemodynamic instability 30.97 9.91 142 310117 17240 79416889
Compartment syndrome 30.95 9.91 64 310195 5018 79429111
Tongue haemorrhage 30.94 9.91 28 310231 981 79433148
Haemorrhagic infarction 30.92 9.91 25 310234 749 79433380
Chills 30.86 9.91 438 309821 159796 79274333
Tenosynovitis 30.76 9.91 11 310248 15543 79418586
Thrombotic cerebral infarction 30.63 9.91 22 310237 550 79433579
Schizophrenia 30.40 9.91 11 310248 15429 79418700
Hypovolaemic shock 30.38 9.91 111 310148 12165 79421964
Blood pressure fluctuation 30.31 9.91 146 310113 66999 79367130
Breast cancer 30.31 9.91 53 310206 33728 79400401
Myopathy 30.22 9.91 159 310100 20404 79413725
Blood parathyroid hormone decreased 30.15 9.91 3 310256 10533 79423596
Colonic haematoma 30.13 9.91 12 310247 83 79434046
Abnormal loss of weight 30.05 9.91 86 310173 8290 79425839
Erosive duodenitis 29.88 9.91 39 310220 2078 79432051
Coronary revascularisation 29.79 9.91 10 310249 39 79434090
Venoocclusive liver disease 29.73 9.91 5 310254 11766 79422363
Hydrocephalus 29.65 9.91 89 310170 8811 79425318
Peptic ulcer haemorrhage 29.64 9.91 27 310232 954 79433175
Septic shock 29.55 9.91 320 309939 122481 79311648
Mucosal haemorrhage 29.52 9.91 43 310216 2543 79431586
Implant site haematoma 29.32 9.91 14 310245 157 79433972
Poisoning 29.30 9.91 33 310226 25239 79408890
General physical health deterioration 29.20 9.91 1330 308929 273908 79160221
Cerebrovascular disorder 29.13 9.91 52 310207 3653 79430476
Oesophageal spasm 29.12 9.91 50 310209 3406 79430723
Ear pain 29.10 9.91 52 310207 32817 79401312
Leukopenia 29.10 9.91 301 309958 116212 79317917
Anhedonia 29.03 9.91 125 310134 14773 79419356
Appendicitis 28.98 9.91 23 310236 20771 79413358
Anaemia macrocytic 28.96 9.91 66 310193 5531 79428598
Coronary ostial stenosis 28.78 9.91 14 310245 164 79433965
Akathisia 28.68 9.91 8 310251 13251 79420878
Oesophageal mucosal dissection 28.61 9.91 9 310250 27 79434102
Thalamus haemorrhage 28.60 9.91 35 310224 1747 79432382
Oral herpes 28.53 9.91 39 310220 27415 79406714
Therapeutic response shortened 28.47 9.91 13 310246 15850 79418279
Haemangioma of spleen 28.39 9.91 8 310251 14 79434115
Lower limb fracture 28.38 9.91 29 310230 23186 79410943
Ear infection 28.27 9.91 57 310202 34375 79399754
Aspergillus infection 28.24 9.91 20 310239 19141 79414988
Blood cholesterol increased 28.20 9.91 200 310059 83520 79350609
Ulcer haemorrhage 28.19 9.91 67 310192 5771 79428358
CYP2C19 polymorphism 28.12 9.91 7 310252 5 79434124
Facet joint syndrome 28.10 9.91 5 310254 11297 79422832
Tongue haematoma 28.06 9.91 15 310244 217 79433912
Hepatotoxicity 27.91 9.91 104 310155 51248 79382881
Myocarditis 27.90 9.91 26 310233 21707 79412422
Pneumonitis 27.67 9.91 132 310127 60728 79373401
Spinal subdural haematoma 27.64 9.91 15 310244 224 79433905
Joint effusion 27.62 9.91 18 310241 17996 79416133
Sudden cardiac death 27.47 9.91 62 310197 5163 79428966
Urinary retention 27.42 9.91 339 309920 56291 79377838
Gangrene 27.41 9.91 87 310172 8877 79425252
Product substitution issue 27.32 9.91 153 310106 20103 79414026
Kidney rupture 27.29 9.91 15 310244 230 79433899
Bundle branch block right 27.22 9.91 101 310158 11150 79422979
Epstein-Barr virus infection 27.17 9.91 11 310248 14405 79419724
Aortic dissection 27.12 9.91 54 310205 4121 79430008
Basal ganglia haemorrhage 27.11 9.91 33 310226 1638 79432491
Brain contusion 27.11 9.91 30 310229 1343 79432786
Blood cholesterol 27.10 9.91 22 310237 663 79433466
Impaired quality of life 27.08 9.91 11 310248 14375 79419754
Mania 26.99 9.91 19 310240 18241 79415888
Retinal artery occlusion 26.89 9.91 47 310212 3247 79430882
Full blood count abnormal 26.85 9.91 75 310184 40399 79393730
Crying 26.82 9.91 30 310229 23013 79411116
Sleep disorder due to a general medical condition 26.74 9.91 11 310248 14266 79419863
Chest discomfort 26.72 9.91 715 309544 137329 79296800
Purpura 26.67 9.91 148 310111 19379 79414750
Sinus bradycardia 26.66 9.91 179 310080 25068 79409061
Spinal cord compression 26.39 9.91 69 310190 6308 79427821
Carotid artery disease 26.36 9.91 38 310221 2226 79431903
Caesarean section 26.31 9.91 8 310251 12527 79421602
Wound haematoma 26.31 9.91 13 310246 158 79433971
Dilatation ventricular 26.20 9.91 53 310206 4091 79430038
Brain stem stroke 26.17 9.91 22 310237 697 79433432
Swollen tongue 26.14 9.91 267 309992 42303 79391826
Traumatic intracranial haemorrhage 26.12 9.91 28 310231 1209 79432920
Arterial stent insertion 26.05 9.91 11 310248 90 79434039
Lymphatic fistula 26.04 9.91 23 310236 780 79433349
Respiratory depression 26.03 9.91 42 310217 27588 79406541
Helicobacter test positive 26.02 9.91 29 310230 1309 79432820
Product monitoring error 25.93 9.91 85 310174 8821 79425308
Hemiataxia 25.88 9.91 9 310250 40 79434089
Labelled drug-disease interaction medication error 25.87 9.91 16 310243 309 79433820
Urinary bladder haemorrhage 25.86 9.91 40 310219 2496 79431633
Brain stem haemorrhage 25.83 9.91 32 310227 1618 79432511
Blood pressure diastolic abnormal 25.82 9.91 22 310237 19180 79414949
Psychotic disorder 25.81 9.91 79 310180 41323 79392806
Colitis 25.74 9.91 173 310086 73134 79360995
Death 25.42 9.91 1879 308380 564635 78869494
Injection site warmth 25.26 9.91 13 310246 14794 79419335
Hypoaesthesia 25.21 9.91 519 309740 178833 79255296
Exposure to toxic agent 25.21 9.91 3 310256 9155 79424974
Capillary fragility test 25.19 9.91 8 310251 25 79434104
Chromaturia 25.09 9.91 179 310080 25567 79408562
Lymphadenopathy 25.09 9.91 114 310145 53133 79380996
Adjustment disorder with depressed mood 24.95 9.91 3 310256 9083 79425046
Muscle spasticity 24.95 9.91 28 310231 21447 79412682
Arteriosclerotic gangrene 24.89 9.91 10 310249 71 79434058
Colitis ulcerative 24.86 9.91 62 310197 34680 79399449
Cholestasis 24.83 9.91 311 309948 51798 79382331
Myocardial necrosis marker increased 24.81 9.91 45 310214 3201 79430928
Erosive oesophagitis 24.68 9.91 42 310217 2840 79431289
Palmar-plantar erythrodysaesthesia syndrome 24.60 9.91 58 310201 33076 79401053
Coma scale abnormal 24.53 9.91 82 310177 8596 79425533
Hypoglycaemic coma 24.49 9.91 56 310203 4704 79429425
Oesophageal ulcer 24.43 9.91 71 310188 6904 79427225
Traumatic haemorrhage 24.40 9.91 28 310231 1305 79432824
Haemorrhagic diathesis 24.33 9.91 65 310194 6019 79428110
Extravasation blood 24.31 9.91 17 310242 407 79433722
Cerebellar haematoma 24.27 9.91 20 310239 616 79433513
Uveitis 24.24 9.91 18 310241 16812 79417317
Gastrointestinal ulcer 24.12 9.91 46 310213 3400 79430729
Mood swings 24.12 9.91 25 310234 19855 79414274
Pulmonary valve disease 24.11 9.91 15 310244 293 79433836
Periorbital haematoma 24.09 9.91 24 310235 950 79433179
Platelet count decreased 24.02 9.91 575 309684 194089 79240040
Oesophageal pain 23.88 9.91 52 310207 4227 79429902
Mitral valve calcification 23.75 9.91 29 310230 1444 79432685
Respiratory syncytial virus infection 23.73 9.91 4 310255 9398 79424731
Cardiac stress test abnormal 23.72 9.91 22 310237 796 79433333
Ventricular hypertrophy 23.70 9.91 70 310189 6868 79427261
Night sweats 23.68 9.91 113 310146 51982 79382147
Cardiac failure acute 23.59 9.91 140 310119 18789 79415340
Haematoma muscle 23.58 9.91 39 310220 2576 79431553
Constipation 23.52 9.91 882 309377 282168 79151961
Toxic skin eruption 23.50 9.91 158 310101 22135 79411994
Coronary artery embolism 23.49 9.91 15 310244 307 79433822
Peptic ulcer 23.41 9.91 65 310194 6158 79427971
Left ventricular dysfunction 23.36 9.91 142 310117 19219 79414910
Cardiac procedure complication 23.36 9.91 16 310243 370 79433759
Acute left ventricular failure 23.29 9.91 32 310227 1792 79432337
Respiratory arrest 23.24 9.91 130 310129 57420 79376709
Femoral hernia incarcerated 23.17 9.91 22 310237 820 79433309
Cholestatic liver injury 23.10 9.91 56 310203 4885 79429244
Device dislocation 23.07 9.91 41 310218 25929 79408200
Cerebral artery stenosis 23.01 9.91 21 310238 744 79433385
Poor venous access 22.96 9.91 22 310237 18127 79416002
Vascular occlusion 22.93 9.91 29 310230 1497 79432632
Osteoarthritis 22.86 9.91 223 310036 87086 79347043
Throat irritation 22.86 9.91 82 310177 40864 79393265
Mucormycosis 22.76 9.91 3 310256 8466 79425663
Jaundice 22.74 9.91 312 309947 53037 79381092
Catheterisation cardiac 22.71 9.91 61 310198 5667 79428462
Iliac artery stenosis 22.67 9.91 12 310247 170 79433959
Arterial disorder 22.59 9.91 33 310226 1957 79432172
Postinfarction angina 22.41 9.91 8 310251 39 79434090
Plasma cell myeloma 22.23 9.91 119 310140 53140 79380989
Thyroid haemorrhage 22.12 9.91 10 310249 98 79434031
Lipoprotein (a) increased 22.04 9.91 9 310250 67 79434062
Benign gastrointestinal neoplasm 21.95 9.91 11 310248 138 79433991
Respiratory tract infection 21.90 9.91 106 310153 48583 79385546
Rales 21.84 9.91 143 310116 19858 79414271
Intra-abdominal haemorrhage 21.81 9.91 52 310207 4488 79429641
Ovarian cyst 21.75 9.91 11 310248 12644 79421485
Haemorrhoidal haemorrhage 21.75 9.91 67 310192 6728 79427401
Tardive dyskinesia 21.74 9.91 7 310252 10564 79423565
Hospitalisation 21.71 9.91 248 310011 93988 79340141
Haemorrhagic erosive gastritis 21.67 9.91 20 310239 719 79433410
Physical examination abnormal 21.57 9.91 14 310245 295 79433834
Implantable defibrillator insertion 21.57 9.91 23 310236 987 79433142
Breast cancer stage II 21.53 9.91 3 310256 8117 79426012
Medication error 21.46 9.91 381 309878 68261 79365868
Platelet dysfunction 21.41 9.91 16 310243 426 79433703
Low density lipoprotein increased 21.37 9.91 78 310181 8544 79425585
Cytomegalovirus infection reactivation 21.36 9.91 4 310255 8712 79425417
Metastases to bone 21.31 9.91 39 310220 24388 79409741
Drug level decreased 21.27 9.91 15 310244 14387 79419742
Wound infection 21.20 9.91 38 310221 23953 79410176
Prostatic adenoma 21.19 9.91 10 310249 109 79434020
Vomiting 21.14 9.91 2268 307991 663560 78770569
Glomerular filtration rate decreased 21.07 9.91 156 310103 22546 79411583
Orbital compartment syndrome 21.07 9.91 9 310250 76 79434053
Brain stem infarction 21.02 9.91 32 310227 1969 79432160
Diabetes mellitus inadequate control 20.99 9.91 164 310095 24100 79410029
Lacunar stroke 20.95 9.91 15 310244 373 79433756
Pancreatic steatosis 20.87 9.91 24 310235 1121 79433008
Coeliac disease 20.85 9.91 9 310250 11342 79422787
Nicotine dependence 20.84 9.91 22 310237 933 79433196
Aneurysm 20.81 9.91 44 310215 3504 79430625
Vascular procedure complication 20.71 9.91 7 310252 28 79434101
Dislocation of vertebra 20.69 9.91 3 310256 7877 79426252
Infusion site pain 20.63 9.91 15 310244 14161 79419968
Device issue 20.49 9.91 47 310212 27061 79407068
Parinaud syndrome 20.45 9.91 6 310253 13 79434116
Wrong dosage formulation 20.43 9.91 5 310254 3 79434126
Pneumonia fungal 20.41 9.91 9 310250 11201 79422928
Potentiating drug interaction 20.37 9.91 78 310181 8741 79425388
Fear 20.36 9.91 151 310108 21835 79412294
Body temperature decreased 20.28 9.91 61 310198 32084 79402045
Ventricular arrhythmia 20.27 9.91 78 310181 8762 79425367
Traumatic haemothorax 20.27 9.91 17 310242 537 79433592
Premature labour 20.25 9.91 4 310255 8386 79425743
Thoracic haemorrhage 20.24 9.91 12 310247 214 79433915
Hypercalcaemia 20.13 9.91 79 310180 38351 79395778
Basal cell carcinoma 20.11 9.91 76 310183 37299 79396830
Amaurosis fugax 20.06 9.91 21 310238 882 79433247
Autoimmune disorder 20.03 9.91 21 310238 16591 79417538
Pulmonary oedema 20.01 9.91 467 309792 87787 79346342
Chronic sinusitis 20.00 9.91 13 310246 13013 79421116
Cerebral atrophy 19.97 9.91 73 310186 8002 79426127
Angiodysplasia 19.92 9.91 23 310236 1079 79433050
Metastases to liver 19.89 9.91 51 310208 28263 79405866
Prescribed overdose 19.76 9.91 78 310181 37805 79396324
Viral infection 19.73 9.91 93 310166 42923 79391206
Subacute hepatic failure 19.72 9.91 12 310247 225 79433904
Progressive multifocal leukoencephalopathy 19.71 9.91 31 310228 20569 79413560
Cardiac valve disease 19.68 9.91 58 310201 5683 79428446
Breast cancer female 19.64 9.91 10 310249 11451 79422678
Hepatitis cholestatic 19.60 9.91 106 310153 13746 79420383
Sciatica 19.58 9.91 65 310194 33157 79400972
Subacute cutaneous lupus erythematosus 19.56 9.91 43 310216 3518 79430611
Heart rate increased 19.53 9.91 341 309918 120383 79313746
Ventricle rupture 19.49 9.91 9 310250 93 79434036
Impaired work ability 19.42 9.91 29 310230 19652 79414477
Injection site urticaria 19.42 9.91 13 310246 12813 79421316
Pericardial disease 19.41 9.91 17 310242 570 79433559
Frequent bowel movements 19.40 9.91 55 310204 29484 79404645
Cold sweat 19.40 9.91 132 310127 18567 79415562
Anastomotic infection 19.38 9.91 10 310249 134 79433995
Accidental exposure to product 19.36 9.91 60 310199 31262 79402867
Metallosis of globe 19.32 9.91 5 310254 5 79434124
Bladder tamponade 19.29 9.91 17 310242 575 79433554
Fear of injection 19.27 9.91 3 310256 7471 79426658
Orthopnoea 19.23 9.91 84 310175 9989 79424140
Rhinorrhoea 19.21 9.91 196 310063 75878 79358251
Drug tolerance 19.21 9.91 5 310254 8670 79425459
Pericardial effusion 19.14 9.91 269 309990 45968 79388161
Vascular device infection 19.11 9.91 8 310251 10268 79423861
Renal artery stenosis 19.07 9.91 42 310217 3440 79430689
Sodium retention 19.07 9.91 11 310248 186 79433943
Ankylosing spondylitis 18.98 9.91 12 310247 12193 79421936
Haemorrhagic cerebral infarction 18.97 9.91 26 310233 1453 79432676
Subcapsular renal haematoma 18.95 9.91 19 310240 758 79433371
Vascular stenosis 18.94 9.91 17 310242 589 79433540
Albumin urine present 18.91 9.91 18 310241 673 79433456
Left ventricular hypertrophy 18.90 9.91 90 310169 11101 79423028
Cerebellar infarction 18.87 9.91 43 310216 3604 79430525
Reperfusion injury 18.86 9.91 11 310248 190 79433939
Carotid bruit 18.83 9.91 19 310240 764 79433365
Gastroenteritis viral 18.81 9.91 43 310216 24788 79409341
Catheter site haemorrhage 18.81 9.91 53 310206 5064 79429065
Device breakage 18.77 9.91 9 310250 10666 79423463
Anxiety 18.77 9.91 783 309476 247729 79186400
Cerebral artery occlusion 18.74 9.91 28 310231 1694 79432435
Crush syndrome 18.51 9.91 11 310248 197 79433932
Dilatation atrial 18.42 9.91 43 310216 3661 79430468
Mydriasis 18.40 9.91 25 310234 17618 79416511
Hypertensive crisis 18.31 9.91 141 310118 20629 79413500
Increased tendency to bruise 18.29 9.91 85 310174 10379 79423750
Post procedural myocardial infarction 18.28 9.91 7 310252 43 79434086
Paradoxical drug reaction 18.26 9.91 3 310256 7182 79426947
Hepatic encephalopathy 18.18 9.91 42 310217 24124 79410005
Bacteraemia 18.15 9.91 66 310193 32758 79401371
Epiglottic oedema 18.10 9.91 13 310246 325 79433804
Dry eye 18.04 9.91 78 310181 36853 79397276
Social problem 18.02 9.91 25 310234 1413 79432716
Clostridium difficile infection 18.02 9.91 95 310164 42590 79391539
Skin infection 17.89 9.91 27 310232 18218 79415911
Myocardial haemorrhage 17.88 9.91 7 310252 46 79434083
Amenorrhoea 17.88 9.91 4 310255 7688 79426441
Arterial thrombosis 17.87 9.91 35 310224 2639 79431490
Vertigo 17.70 9.91 372 309887 68710 79365419
Insulin C-peptide increased 17.68 9.91 9 310250 117 79434012
Vascular pseudoaneurysm ruptured 17.66 9.91 10 310249 163 79433966
Tracheal haemorrhage 17.66 9.91 17 310242 645 79433484
Soft tissue haemorrhage 17.62 9.91 14 310245 409 79433720
Bronchiectasis 17.58 9.91 38 310221 22348 79411781
Non-small cell lung cancer recurrent 17.55 9.91 9 310250 119 79434010
Incorrect route of product administration 17.54 9.91 73 310186 34856 79399273
Gastrointestinal angiectasia 17.53 9.91 14 310245 412 79433717
Product substitution error 17.51 9.91 7 310252 49 79434080
Retro-orbital neoplasm 17.51 9.91 7 310252 49 79434080
Laryngitis 17.47 9.91 22 310237 16017 79418112
Nephrosclerosis 17.46 9.91 28 310231 1802 79432327
Tuberculosis 17.45 9.91 20 310239 15178 79418951
Encephalitis 17.41 9.91 19 310240 14741 79419388
Aneurysm ruptured 17.40 9.91 20 310239 934 79433195
Femoral neck fracture 17.37 9.91 81 310178 9903 79424226
Joint injury 17.33 9.91 63 310196 31272 79402857
Cough 17.33 9.91 1211 309048 365578 79068551
Bradyarrhythmia 17.30 9.91 45 310214 4101 79430028
Paraplegia 17.28 9.91 51 310208 5002 79429127
Coagulopathy 17.20 9.91 215 310044 35791 79398338
Muscle rupture 17.17 9.91 42 310217 3685 79430444
Gastrointestinal arteriovenous malformation 17.16 9.91 20 310239 948 79433181
Biliary cirrhosis 17.14 9.91 10 310249 173 79433956
Hepatorenal failure 17.10 9.91 23 310236 1262 79432867
Blindness transient 17.10 9.91 49 310210 4727 79429402
Cardiac discomfort 17.06 9.91 23 310236 1265 79432864
Post-traumatic amnestic disorder 17.04 9.91 7 310252 53 79434076
Confusional state 16.93 9.91 1447 308812 316550 79117579
Lip swelling 16.93 9.91 238 310021 40673 79393456
Tumour lysis syndrome 16.91 9.91 43 310216 23896 79410233
Sinus node dysfunction 16.88 9.91 67 310192 7634 79426495
Mitral valve disease 16.88 9.91 38 310221 3159 79430970
Photophobia 16.84 9.91 34 310225 20494 79413635
Liver injury 16.83 9.91 140 310119 56474 79377655
Lichen nitidus 16.81 9.91 8 310251 89 79434040
Urticaria 16.76 9.91 571 309688 184630 79249499
Amblyopia 16.74 9.91 11 310248 237 79433892
Oesophagitis ulcerative 16.73 9.91 22 310237 1181 79432948
Candida infection 16.72 9.91 84 310175 38130 79395999
Resuscitation 16.72 9.91 32 310227 2372 79431757
Intrapericardial thrombosis 16.71 9.91 7 310252 56 79434073
Haemorrhage coronary artery 16.69 9.91 5 310254 12 79434117
Aortic valve replacement 16.69 9.91 23 310236 1292 79432837
Mitral valve hypoplasia 16.69 9.91 6 310253 30 79434099
Shone complex 16.69 9.91 6 310253 30 79434099
Pain in jaw 16.66 9.91 108 310151 46043 79388086
Monoparesis 16.64 9.91 40 310219 3471 79430658
Ear haemorrhage 16.61 9.91 30 310229 2127 79432002
Intracranial aneurysm 16.60 9.91 47 310212 4503 79429626
Strangury 16.55 9.91 10 310249 185 79433944
Body temperature increased 16.53 9.91 103 310156 44317 79389812
Congenital aortic valve stenosis 16.52 9.91 6 310253 31 79434098
Metastases to lymph nodes 16.48 9.91 10 310249 10387 79423742
Tongue disorder 16.48 9.91 18 310241 13957 79420172
Seroma 16.47 9.91 31 310228 2269 79431860
Dyslipidaemia 16.45 9.91 89 310170 11544 79422585
Alanine aminotransferase increased 16.44 9.91 494 309765 162076 79272053
Anaphylactic reaction 16.44 9.91 228 310031 83515 79350614
Aspartate aminotransferase increased 16.42 9.91 412 309847 138229 79295900
Reocclusion 16.41 9.91 5 310254 13 79434116
Aorta hypoplasia 16.37 9.91 6 310253 32 79434097
Activated partial thromboplastin time prolonged 16.32 9.91 103 310156 14125 79420004
Hypothyroidism 16.29 9.91 128 310131 52264 79381865
Spinal cord haematoma 16.27 9.91 12 310247 313 79433816
Diffuse large B-cell lymphoma 16.24 9.91 14 310245 12135 79421994
Iliac artery occlusion 16.20 9.91 12 310247 315 79433814
Hot flush 16.18 9.91 136 310123 54741 79379388
Duodenal vascular ectasia 16.15 9.91 5 310254 14 79434115
Haematocoele 16.15 9.91 5 310254 14 79434115
BK virus infection 16.14 9.91 7 310252 8797 79425332
Erythema 16.13 9.91 707 309552 222583 79211546
Vessel puncture site haemorrhage 16.13 9.91 10 310249 194 79433935
Diabetic macroangiopathy 16.09 9.91 9 310250 143 79433986
Arteriospasm coronary 16.01 9.91 60 310199 6656 79427473
Hypochromic anaemia 16.00 9.91 34 310225 2717 79431412
Peripheral artery stent insertion 15.99 9.91 4 310255 3 79434126
Incision site haematoma 15.98 9.91 9 310250 145 79433984
Oxygen saturation decreased 15.96 9.91 381 309878 128666 79305463
Consciousness fluctuating 15.95 9.91 28 310231 1941 79432188
Type IIa hyperlipidaemia 15.92 9.91 11 310248 258 79433871
Device use error 15.90 9.91 4 310255 7097 79427032
Haematospermia 15.89 9.91 11 310248 259 79433870
Rectal ulcer 15.87 9.91 29 310230 2075 79432054
Skin haemorrhage 15.83 9.91 90 310169 11891 79422238
Polyp 15.78 9.91 68 310191 8039 79426090
Pituitary apoplexy 15.73 9.91 10 310249 203 79433926
Aortic intramural haematoma 15.61 9.91 9 310250 152 79433977
Troponin T increased 15.50 9.91 39 310220 3483 79430646
Gastrointestinal ulcer haemorrhage 15.49 9.91 22 310237 1271 79432858
Supine hypertension 15.49 9.91 13 310246 411 79433718
Diastolic dysfunction 15.48 9.91 83 310176 10728 79423401
Hypoglycaemic unconsciousness 15.48 9.91 21 310238 1162 79432967
Glycosylated haemoglobin increased 15.47 9.91 128 310131 19132 79414997
Ascites 15.46 9.91 204 310055 75358 79358771
Hypotonic urinary bladder 15.45 9.91 7 310252 69 79434060
Troponin I increased 15.43 9.91 47 310212 4691 79429438
Rectosigmoid cancer 15.42 9.91 11 310248 272 79433857
Amaurosis 15.37 9.91 21 310238 1170 79432959
Hypocoagulable state 15.33 9.91 29 310230 2130 79431999
Metastases to central nervous system 15.33 9.91 25 310234 16350 79417779
Pulseless electrical activity 15.31 9.91 101 310158 14059 79420070
Pericardial fibrosis 15.31 9.91 9 310250 158 79433971
Carotid artery dissection 15.27 9.91 12 310247 345 79433784
Angiogram 15.26 9.91 8 310251 111 79434018
Congenital heart valve disorder 15.25 9.91 6 310253 40 79434089
Pharyngeal haemorrhage 15.19 9.91 22 310237 1294 79432835
Anal prolapse 15.19 9.91 7 310252 72 79434057
Eyelid bleeding 15.19 9.91 7 310252 72 79434057
Nerve degeneration 15.14 9.91 11 310248 280 79433849
Hyperbilirubinaemia 15.13 9.91 47 310212 24471 79409658
Cutaneous lupus erythematosus 15.09 9.91 35 310224 2968 79431161
Anti-insulin antibody increased 15.01 9.91 8 310251 115 79434014
Heart disease congenital 14.99 9.91 15 310244 597 79433532
Influenza virus test positive 14.94 9.91 12 310247 356 79433773
Oesophageal ulcer haemorrhage 14.93 9.91 15 310244 600 79433529
Sweat gland tumour 14.92 9.91 14 310245 514 79433615
Mucosal membrane hyperplasia 14.89 9.91 6 310253 43 79434086
Influenza like illness 14.88 9.91 193 310066 71514 79362615
Long QT syndrome 14.86 9.91 54 310205 5901 79428228
Chest wall haematoma 14.84 9.91 13 310246 436 79433693
Acid base balance abnormal 14.83 9.91 12 310247 360 79433769
Blood pressure diastolic increased 14.77 9.91 21 310238 14521 79419608
Peripheral artery thrombosis 14.73 9.91 38 310221 3445 79430684
Cerebellar ischaemia 14.72 9.91 10 310249 228 79433901
Left ventricular failure 14.71 9.91 75 310184 9506 79424623
Personality disorder 14.69 9.91 3 310256 6143 79427986
Eyelid retraction 14.65 9.91 6 310253 45 79434084
Facial nerve disorder 14.65 9.91 16 310243 706 79433423
Coronary no-reflow phenomenon 14.60 9.91 5 310254 21 79434108
Systemic candida 14.59 9.91 4 310255 6702 79427427
Factor V inhibition 14.58 9.91 12 310247 369 79433760
Exophthalmos 14.54 9.91 25 310234 1705 79432424
Right ventricular diastolic collapse 14.47 9.91 7 310252 81 79434048
Ventricular enlargement 14.46 9.91 16 310243 716 79433413
Eructation 14.45 9.91 82 310177 10827 79423302
Neutrophil count increased 14.41 9.91 62 310197 29334 79404795
Arterial injury 14.39 9.91 16 310243 720 79433409
Wound infection pseudomonas 14.38 9.91 24 310235 1597 79432532
Vascular purpura 14.36 9.91 35 310224 3063 79431066
Contrast encephalopathy 14.32 9.91 9 310250 179 79433950
Gallbladder neoplasm 14.24 9.91 7 310252 84 79434045
Amyloidosis senile 14.22 9.91 6 310253 49 79434080
Arteriovenous malformation 14.21 9.91 25 310234 1736 79432393
Gastric mucosal lesion 14.15 9.91 18 310241 935 79433194
Pelvic haematoma 14.08 9.91 17 310242 837 79433292
Gastric antral vascular ectasia 14.07 9.91 18 310241 940 79433189
Product storage error 14.07 9.91 26 310233 16200 79417929
Procedural complication 14.06 9.91 65 310194 7918 79426211
Prostate examination abnormal 14.06 9.91 9 310250 185 79433944
Administration site discomfort 14.04 9.91 8 310251 132 79433997
Cushingoid 14.04 9.91 10 310249 9542 79424587
Anal polyp 14.03 9.91 7 310252 87 79434042
Aortic aneurysm rupture 14.02 9.91 21 310238 1274 79432855
Eyelid haematoma 14.01 9.91 6 310253 51 79434078
Optic neuritis 13.95 9.91 10 310249 9510 79424619
Vaginal haematoma 13.94 9.91 8 310251 134 79433995
Anal stenosis 13.93 9.91 13 310246 474 79433655
Congenital aortic anomaly 13.90 9.91 5 310254 25 79434104
Supravalvular aortic stenosis 13.90 9.91 5 310254 25 79434104
Congenital aortic stenosis 13.90 9.91 5 310254 25 79434104
Somnolence 13.89 9.91 774 309485 238207 79195922
Urethral haemorrhage 13.89 9.91 12 310247 395 79433734
Contraindication to medical treatment 13.88 9.91 21 310238 1285 79432844
Disorientation 13.87 9.91 331 309928 62445 79371684
Feeling hot 13.83 9.91 157 310102 59577 79374552
Sensitivity to weather change 13.82 9.91 7 310252 8040 79426089
Foetal death 13.81 9.91 7 310252 8037 79426092
Ventricular extrasystoles 13.77 9.91 127 310132 19577 79414552
Demyelination 13.75 9.91 7 310252 8016 79426113
Therapeutic response increased 13.75 9.91 14 310245 569 79433560
Upper motor neurone lesion 13.72 9.91 10 310249 256 79433873
Prostatomegaly 13.72 9.91 37 310222 3446 79430683
Neuralgia 13.70 9.91 75 310184 33309 79400820
Frustration tolerance decreased 13.70 9.91 6 310253 7496 79426633
Ventricular dysfunction 13.69 9.91 53 310206 5970 79428159
Injection site mass 13.69 9.91 37 310222 20147 79413982
Renal artery thrombosis 13.66 9.91 13 310246 486 79433643
Mastocytic enterocolitis 13.66 9.91 3 310256 0 79434129
Hypothrombinaemia 13.66 9.91 3 310256 0 79434129
Malabsorption from application site 13.66 9.91 3 310256 0 79434129
Arteriovenous graft thrombosis 13.66 9.91 3 310256 0 79434129
Brain compression 13.65 9.91 14 310245 574 79433555
Livedo reticularis 13.64 9.91 41 310218 4062 79430067
Blood glucose decreased 13.55 9.91 159 310100 26075 79408054
Multiple sclerosis 13.55 9.91 43 310216 22239 79411890
Nodule 13.54 9.91 45 310214 22949 79411180
Device inappropriate shock delivery 13.52 9.91 6 310253 56 79434073
Memory impairment 13.51 9.91 331 309928 111403 79322726
Bone pain 13.51 9.91 145 310114 55597 79378532
Dyspnoea paroxysmal nocturnal 13.50 9.91 28 310231 2200 79431929
Immunosuppression 13.49 9.91 18 310241 12785 79421344
Serum ferritin abnormal 13.49 9.91 12 310247 411 79433718
Amputation 13.45 9.91 16 310243 775 79433354
No adverse event 13.44 9.91 87 310172 37105 79397024
Hypokinesia 13.40 9.91 123 310136 18937 79415192
Mitral valve thickening 13.39 9.91 12 310247 415 79433714
Groin pain 13.37 9.91 92 310167 12988 79421141
Blood calcium decreased 13.33 9.91 71 310188 31748 79402381
Preternatural anus 13.30 9.91 7 310252 98 79434031
Rectal perforation 13.29 9.91 17 310242 888 79433241
Hepatic haemorrhage 13.27 9.91 18 310241 996 79433133
Intracranial mass 13.23 9.91 28 310231 2231 79431898
Sarcoidosis 13.23 9.91 8 310251 8327 79425802
Parkinsonian rest tremor 13.23 9.91 10 310249 271 79433858
Eye irritation 13.22 9.91 39 310220 20642 79413487
Splenic haemorrhage 13.21 9.91 15 310244 691 79433438
Neutropenic colitis 13.20 9.91 3 310256 5704 79428425
Macular ischaemia 13.17 9.91 7 310252 100 79434029
Skin oedema 13.13 9.91 24 310235 1717 79432412
Forced expiratory volume decreased 13.12 9.91 7 310252 7807 79426322
Acute right ventricular failure 13.05 9.91 11 310248 350 79433779
Febrile bone marrow aplasia 13.03 9.91 19 310240 13001 79421128
Ileus 13.02 9.91 55 310204 26156 79407973
Exercise tolerance increased 13.02 9.91 5 310254 31 79434098
Retinitis 12.98 9.91 3 310256 5640 79428489
Vascular encephalopathy 12.98 9.91 14 310245 609 79433520
Arterial perforation 12.97 9.91 4 310255 11 79434118
Peripheral artery restenosis 12.97 9.91 4 310255 11 79434118
Cutaneous vasculitis 12.96 9.91 65 310194 8187 79425942
Physical disability 12.95 9.91 35 310224 3263 79430866
Procedural hypotension 12.94 9.91 26 310233 1997 79432132
Large intestine perforation 12.94 9.91 23 310236 14544 79419585
Cardiac ventricular disorder 12.91 9.91 11 310248 355 79433774
Electrocardiogram change 12.89 9.91 20 310239 1251 79432878
Interventricular septum rupture 12.88 9.91 5 310254 32 79434097
Conjunctival pallor 12.87 9.91 8 310251 156 79433973
Paraesthesia 12.79 9.91 558 309701 175765 79258364
Concomitant disease progression 12.79 9.91 36 310223 3437 79430692
Diabetic foot 12.75 9.91 37 310222 3595 79430534
Oesophageal dilatation 12.74 9.91 12 310247 443 79433686
Systemic infection 12.72 9.91 73 310186 9679 79424450
Venous recanalisation 12.71 9.91 4 310255 12 79434117
Capsular warning syndrome 12.71 9.91 4 310255 12 79434117
Patent ductus arteriosus 12.70 9.91 7 310252 108 79434021
Myxoedema coma 12.69 9.91 15 310244 722 79433407
Thrombocytopenic purpura 12.65 9.91 29 310230 2440 79431689
Arterial insufficiency 12.61 9.91 11 310248 367 79433762
Angioimmunoblastic T-cell lymphoma 12.54 9.91 12 310247 452 79433677
Coarctation of the aorta 12.51 9.91 6 310253 68 79434061
Skin disorder 12.47 9.91 79 310180 33864 79400265
Oral candidiasis 12.47 9.91 66 310193 29562 79404567
Tooth disorder 12.45 9.91 56 310203 26177 79407952
Duplicate therapy error 12.44 9.91 10 310249 297 79433832
Heart sounds abnormal 12.43 9.91 21 310238 1412 79432717
Procedural pain 12.38 9.91 47 310212 23037 79411092
Normal newborn 12.38 9.91 6 310253 7066 79427063
Withdrawal syndrome 12.35 9.91 58 310201 26796 79407333
Ruptured cerebral aneurysm 12.34 9.91 13 310246 550 79433579
Abdominal tenderness 12.34 9.91 77 310182 10517 79423612
Injection site induration 12.31 9.91 12 310247 9807 79424322
Blood creatinine abnormal 12.29 9.91 44 310215 4773 79429356
Extrapyramidal disorder 12.28 9.91 46 310213 22633 79411496
Cardioactive drug level increased 12.27 9.91 37 310222 3672 79430457
Haematocrit decreased 12.27 9.91 319 309940 60993 79373136
Nephrogenic systemic fibrosis 12.25 9.91 52 310207 6108 79428021
Cardiac pacemaker insertion 12.24 9.91 50 310209 5772 79428357
Intestinal ischaemia 12.21 9.91 91 310168 13179 79420950
Aortic valve calcification 12.16 9.91 15 310244 755 79433374
Catheter site pain 12.16 9.91 3 310256 5393 79428736
Diffuse vasculitis 12.15 9.91 7 310252 118 79434011
Laryngeal haematoma 12.15 9.91 8 310251 173 79433956
Rhinovirus infection 12.12 9.91 8 310251 7945 79426184
Alanine aminotransferase abnormal 12.12 9.91 10 310249 8857 79425272
Device related thrombosis 12.11 9.91 30 310229 2653 79431476
Klebsiella infection 12.09 9.91 27 310232 15693 79418436
Vaginal discharge 12.08 9.91 7 310252 7456 79426673
Cerebral microhaemorrhage 12.06 9.91 9 310250 239 79433890
Subclavian artery stenosis 12.06 9.91 9 310250 239 79433890
Oesophagitis haemorrhagic 12.04 9.91 14 310245 662 79433467
Device difficult to use 12.01 9.91 21 310238 13364 79420765
Toe amputation 12.00 9.91 38 310221 3873 79430256
Haematoma evacuation 11.97 9.91 10 310249 314 79433815
Device malfunction 11.94 9.91 43 310216 21405 79412724
Blood creatine phosphokinase MM increased 11.94 9.91 5 310254 40 79434089
Substance abuse 11.93 9.91 14 310245 10512 79423617
Mediastinal haemorrhage 11.92 9.91 6 310253 76 79434053
Small intestinal obstruction 11.90 9.91 60 310199 27212 79406917
Disability 11.90 9.91 31 310228 17089 79417040
Exercise tolerance decreased 11.89 9.91 68 310191 9003 79425126
Fistula 11.88 9.91 20 310239 12920 79421209
Affective disorder 11.85 9.91 9 310250 8310 79425819
Deep vein thrombosis 11.84 9.91 369 309890 120550 79313579
Haemorrhagic thyroid cyst 11.84 9.91 4 310255 16 79434113
Paresis cranial nerve 11.83 9.91 5 310254 41 79434088
Catatonia 11.81 9.91 10 310249 8746 79425383
Hepatic cyst 11.80 9.91 51 310208 6038 79428091
Infusion site swelling 11.76 9.91 8 310251 7818 79426311
Ligament pain 11.75 9.91 9 310250 249 79433880
Cerebral artery embolism 11.74 9.91 24 310235 1867 79432262
Blood bilirubin increased 11.72 9.91 184 310075 66048 79368081
Complication of device insertion 11.72 9.91 5 310254 6345 79427784
Nail pitting 11.70 9.91 11 310248 405 79433724
Meningitis 11.68 9.91 12 310247 9570 79424559
Sinus congestion 11.68 9.91 39 310220 19857 79414272
Monoplegia 11.65 9.91 38 310221 3933 79430196
Peripheral artery angioplasty 11.65 9.91 4 310255 17 79434112
Acute hepatic failure 11.63 9.91 69 310190 30044 79404085
Brain natriuretic peptide decreased 11.62 9.91 5 310254 43 79434086
Basilar artery stenosis 11.62 9.91 5 310254 43 79434086
Product preparation error 11.62 9.91 4 310255 5789 79428340
Coronary artery surgery 11.60 9.91 8 310251 187 79433942
Back pain 11.60 9.91 1022 309237 303158 79130971
Puncture site swelling 11.59 9.91 3 310256 3 79434126
Peripheral revascularisation 11.59 9.91 3 310256 3 79434126
Oesophageal dysplasia 11.59 9.91 3 310256 3 79434126
Oral contusion 11.59 9.91 6 310253 81 79434048
Vascular insufficiency 11.58 9.91 12 310247 498 79433631
Syringe issue 11.56 9.91 5 310254 6293 79427836
Conjunctivitis 11.56 9.91 56 310203 25659 79408470
Embolism arterial 11.55 9.91 21 310238 1497 79432632
Gestational diabetes 11.54 9.91 5 310254 6288 79427841
Ischaemic limb pain 11.53 9.91 5 310254 44 79434085
Basal ganglia infarction 11.48 9.91 13 310246 597 79433532
Hysterectomy 11.48 9.91 5 310254 6267 79427862
Blood phosphorus increased 11.47 9.91 14 310245 10333 79423796
Arterial rupture 11.47 9.91 15 310244 801 79433328
High density lipoprotein decreased 11.44 9.91 42 310217 4613 79429516
Adenoma benign 11.44 9.91 18 310241 1140 79432989
Postresuscitation encephalopathy 11.43 9.91 5 310254 45 79434084
Product complaint 11.42 9.91 90 310169 13259 79420870
Exposure via ingestion 11.42 9.91 3 310256 5171 79428958
Lip infection 11.39 9.91 8 310251 193 79433936
Spinal pain 11.38 9.91 27 310232 15365 79418764
Transplant dysfunction 11.37 9.91 7 310252 7214 79426915
Skin weeping 11.36 9.91 17 310242 1030 79433099
Pharyngitis streptococcal 11.36 9.91 15 310244 10699 79423430
Periorbital haemorrhage 11.35 9.91 9 310250 262 79433867
Eye injury 11.35 9.91 29 310230 2614 79431515
Prothrombin time prolonged 11.35 9.91 108 310151 16791 79417338
Tricuspid valve disease 11.35 9.91 11 310248 421 79433708
Dry skin 11.34 9.91 191 310068 67804 79366325
Puncture site reaction 11.29 9.91 4 310255 19 79434110
Heparin-induced thrombocytopenia test positive 11.28 9.91 7 310252 136 79433993
Parainfluenzae virus infection 11.27 9.91 4 310255 5678 79428451
Sneezing 11.27 9.91 39 310220 19644 79414485
Road traffic accident 11.23 9.91 112 310147 43552 79390577
Blood potassium increased 11.20 9.91 168 310091 29107 79405022
Artery dissection 11.15 9.91 9 310250 269 79433860
Toxic encephalopathy 11.15 9.91 17 310242 11423 79422706
Vascular access site haemorrhage 11.15 9.91 5 310254 48 79434081
Cholecystitis acute 11.13 9.91 90 310169 13361 79420768
Thalamic infarction 11.13 9.91 19 310240 1288 79432841
Episcleral venous pressure increased 11.12 9.91 4 310255 20 79434109
Respiratory tract congestion 11.11 9.91 40 310219 19914 79414215
Enterocolitis 11.10 9.91 25 310234 14487 79419642
Poor quality sleep 11.09 9.91 48 310211 22674 79411455
Anal abscess 11.08 9.91 12 310247 9343 79424786
Urinary straining 11.06 9.91 5 310254 49 79434080
Herpes simplex 11.04 9.91 19 310240 12168 79421961
Faecaloma 11.04 9.91 80 310179 11484 79422645
Hypoalbuminaemia 11.01 9.91 44 310215 21253 79412876
Nodal arrhythmia 10.99 9.91 24 310235 1954 79432175
Obstructive shock 10.98 9.91 6 310253 91 79434038
Liver disorder 10.94 9.91 207 310052 72210 79361919
International normalised ratio abnormal 10.94 9.91 48 310211 5720 79428409
Tenderness 10.91 9.91 51 310208 23591 79410538
Inappropriate antidiuretic hormone secretion 10.85 9.91 153 310106 26160 79407969
Nephrolithiasis 10.85 9.91 144 310115 53147 79380982
Mitral valve stenosis 10.85 9.91 18 310241 1192 79432937
Vessel perforation 10.81 9.91 4 310255 22 79434107
Coronary artery aneurysm 10.81 9.91 7 310252 147 79433982
Anuria 10.81 9.91 127 310132 20836 79413293
Second primary malignancy 10.75 9.91 25 310234 14325 79419804
Product odour abnormal 10.74 9.91 19 310240 1325 79432804
Duodenitis haemorrhagic 10.72 9.91 7 310252 149 79433980
Stress 10.70 9.91 232 310027 79380 79354749
Ocular hyperaemia 10.70 9.91 65 310194 28141 79405988
Blood creatine phosphokinase abnormal 10.68 9.91 11 310248 453 79433676
Electrocardiogram ST-T change 10.68 9.91 21 310238 1588 79432541
Mean cell volume decreased 10.67 9.91 3 310256 4944 79429185
Drug effective for unapproved indication 10.64 9.91 5 310254 5996 79428133
Blood pressure orthostatic abnormal 10.64 9.91 6 310253 97 79434032
Brain abscess 10.64 9.91 3 310256 4933 79429196
Exostosis 10.63 9.91 32 310227 16826 79417303
Immune thrombocytopenia 10.61 9.91 111 310148 17694 79416435
Vascular dementia 10.60 9.91 15 310244 864 79433265
Deafness transitory 10.58 9.91 16 310243 979 79433150
Pneumonia viral 10.57 9.91 12 310247 9146 79424983
Change of bowel habit 10.57 9.91 29 310230 2728 79431401
Atrioventricular block first degree 10.57 9.91 84 310175 12407 79421722
Macroangiopathy 10.56 9.91 7 310252 153 79433976
Cognitive disorder 10.53 9.91 200 310059 69726 79364403
Post cardiac arrest syndrome 10.52 9.91 4 310255 24 79434105
Facial pain 10.52 9.91 20 310239 12330 79421799
Uterine leiomyoma 10.49 9.91 6 310253 6437 79427692
Basilar artery thrombosis 10.48 9.91 10 310249 375 79433754
Stroke in evolution 10.48 9.91 6 310253 100 79434029
Blood creatinine increased 10.47 9.91 719 309540 154338 79279791
Obstructive pancreatitis 10.45 9.91 15 310244 875 79433254
Platelet disorder 10.44 9.91 30 310229 2899 79431230
Torsade de pointes 10.40 9.91 118 310141 19194 79414935
Bacterial infection 10.40 9.91 75 310184 31205 79402924
Vitamin B complex deficiency 10.38 9.91 14 310245 770 79433359
Cardiomegaly 10.38 9.91 152 310107 26200 79407929
Hypertensive heart disease 10.38 9.91 38 310221 4168 79429961
Skull fracture 10.35 9.91 22 310237 1758 79432371
Aortic valve sclerosis 10.35 9.91 22 310237 1758 79432371
Nasal polyps 10.34 9.91 8 310251 7319 79426810
Vascular graft complication 10.33 9.91 7 310252 159 79433970
Prosthetic cardiac valve thrombosis 10.32 9.91 5 310254 58 79434071
Eye pruritus 10.32 9.91 43 310216 20527 79413602
Feeling abnormal 10.30 9.91 510 309749 158689 79275440
Red cell distribution width increased 10.29 9.91 28 310231 15214 79418915
Exsanguination 10.27 9.91 6 310253 104 79434025
Nail disorder 10.27 9.91 19 310240 11833 79422296
Contrast media reaction 10.26 9.91 24 310235 2046 79432083
Small intestine polyp 10.25 9.91 4 310255 26 79434103
Basal ganglia haematoma 10.25 9.91 5 310254 59 79434070
Thrombectomy 10.25 9.91 9 310250 303 79433826
Pruritus 10.24 9.91 1362 308897 393286 79040843
Breast cancer metastatic 10.23 9.91 11 310248 8591 79425538
Blood uric acid increased 10.23 9.91 23 310236 13337 79420792
Neoplasm malignant 10.23 9.91 77 310182 31733 79402396
Hyperparathyroidism secondary 10.22 9.91 28 310231 2632 79431497
Basal ganglia stroke 10.21 9.91 7 310252 162 79433967
Kidney transplant rejection 10.20 9.91 15 310244 10231 79423898
Psychological trauma 10.13 9.91 19 310240 1387 79432742
Nightmare 10.12 9.91 149 310110 25712 79408417
Vessel puncture site swelling 10.08 9.91 3 310256 7 79434122
Renal ischaemia 10.04 9.91 17 310242 1145 79432984
Dry mouth 10.04 9.91 263 309996 87756 79346373
Depression 10.02 9.91 717 309542 216073 79218056
Myoglobin blood increased 10.02 9.91 31 310228 3120 79431009
Choroidal haemorrhage 9.99 9.91 7 310252 168 79433961
Generalised tonic-clonic seizure 9.94 9.91 116 310143 43794 79390335
Bladder diverticulum 9.93 9.91 6 310253 111 79434018
Urinary tract infection 9.93 9.91 926 309333 273586 79160543
Aortic thrombosis 9.92 9.91 21 310238 1674 79432455
Feeling jittery 9.92 9.91 22 310237 12819 79421310

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B01AC04 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Platelet aggregation inhibitors excl. heparin
FDA PE N0000008832 Decreased Platelet Aggregation
CHEBI has role CHEBI:50249 anticoagulants
CHEBI has role CHEBI:50427 platelet aggregation inhibitors
CHEBI has role CHEBI:68563 ADP receptor subtype P2Y12 antagonists
MeSH PA D006401 Hematologic Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D010975 Platelet Aggregation Inhibitors
MeSH PA D058914 Purinergic Antagonists
MeSH PA D058919 Purinergic P2 Receptor Antagonists
MeSH PA D058921 Purinergic P2Y Receptor Antagonists
FDA EPC N0000182142 P2Y12 Platelet Inhibitor
FDA MoA N0000182143 P2Y12 Receptor Antagonists
FDA MoA N0000187062 Cytochrome P450 2C8 Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Unstable angina indication 4557003
Atrial fibrillation indication 49436004 DOID:0060224
Cerebral embolism indication 75543006 DOID:4372
Non-Q wave myocardial infarction indication 314207007
Acute coronary syndrome indication 394659003
Acute ST segment elevation myocardial infarction indication 401303003
Prevention of blood clots after heart attack or stroke indication
Peripheral Arterial Thromboembolism Prevention indication
Myocardial Reinfarction Prevention indication
Prevention blood clots forming in hardened blood vessels indication
Intracranial hemorrhage contraindication 1386000
Acute hemorrhage contraindication 8573003
Retinal hemorrhage contraindication 28998008
Gastrointestinal ulcer contraindication 40845000
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Acute hepatic failure contraindication 197270009
Surgical procedure contraindication 387713003
Traumatic injury contraindication 417746004
Poor metabolizer due to cytochrome p450 CYP2C19 variant contraindication 424500005




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.4 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
P2Y purinoceptor 12 GPCR ANTAGONIST Ki 6.90 WOMBAT-PK CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 6.52 DRUG MATRIX
Cytochrome P450 2B6 Enzyme Ki 6.30 WOMBAT-PK

External reference:

IDSource
4024096 VUID
N0000022101 NUI
D00769 KEGG_DRUG
120202-66-6 SECONDARY_CAS_RN
120202-65-5 SECONDARY_CAS_RN
120202-67-7 SECONDARY_CAS_RN
236991 RXNORM
4021078 VANDF
4024096 VANDF
C0070166 UMLSCUI
CHEBI:37941 CHEBI
CGE PDB_CHEM_ID
CHEMBL1771 ChEMBL_ID
DB00758 DRUGBANK_ID
CHEMBL1083385 ChEMBL_ID
D000077144 MESH_DESCRIPTOR_UI
60606 PUBCHEM_CID
7150 IUPHAR_LIGAND_ID
5908 INN_ID
A74586SNO7 UNII
24922 MMSL
4480 MMSL
87809 MMSL
d04258 MMSL
007363 NDDF
007364 NDDF
013218 NDDF
015645 NDDF
015649 NDDF
108979001 SNOMEDCT_US
386952008 SNOMEDCT_US
412354008 SNOMEDCT_US
734471009 SNOMEDCT_US
734972007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Plavix HUMAN PRESCRIPTION DRUG LABEL 1 0024-1171 TABLET, FILM COATED 75 mg ORAL NDA 28 sections
Plavix HUMAN PRESCRIPTION DRUG LABEL 1 0024-1171 TABLET, FILM COATED 75 mg ORAL NDA 28 sections
Plavix HUMAN PRESCRIPTION DRUG LABEL 1 0024-1332 TABLET, FILM COATED 300 mg ORAL NDA 28 sections
Plavix HUMAN PRESCRIPTION DRUG LABEL 1 0024-1332 TABLET, FILM COATED 300 mg ORAL NDA 28 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 0093-7314 TABLET, FILM COATED 75 mg ORAL ANDA 27 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 0093-7314 TABLET, FILM COATED 75 mg ORAL ANDA 27 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 0615-8014 TABLET, FILM COATED 75 mg ORAL ANDA 28 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 0615-8014 TABLET, FILM COATED 75 mg ORAL ANDA 28 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 0615-8014 TABLET, FILM COATED 75 mg ORAL ANDA 28 sections
Clopidogrel Bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6294 TABLET 75 mg ORAL ANDA 20 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 0904-6467 TABLET, FILM COATED 300 mg ORAL ANDA 27 sections
Clopidogrel Bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 13668-141 TABLET 75 mg ORAL ANDA 20 sections
Clopidogrel Bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 13668-141 TABLET 75 mg ORAL ANDA 20 sections
Clopidogrel Bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 13668-141 TABLET 75 mg ORAL ANDA 20 sections
Clopidogrel Bisulfate HUMAN PRESCRIPTION DRUG LABEL 1 13668-141 TABLET 75 mg ORAL ANDA 20 sections
PLAVIX HUMAN PRESCRIPTION DRUG LABEL 1 16590-288 TABLET, FILM COATED 75 mg ORAL NDA 12 sections
Clopidogrel Human Prescription Drug Label 1 16714-052 TABLET 75 mg ORAL ANDA 27 sections
Clopidogrel Human Prescription Drug Label 1 16714-052 TABLET 75 mg ORAL ANDA 27 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 16729-218 TABLET, FILM COATED 75 mg ORAL ANDA 28 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 16729-218 TABLET, FILM COATED 75 mg ORAL ANDA 28 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 16729-219 TABLET, FILM COATED 300 mg ORAL ANDA 28 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 16729-219 TABLET, FILM COATED 300 mg ORAL ANDA 28 sections
Plavix HUMAN PRESCRIPTION DRUG LABEL 1 21695-665 TABLET, FILM COATED 75 mg ORAL NDA 28 sections
clopidogrel Human Prescription Drug Label 1 31722-901 TABLET, FILM COATED 75 mg ORAL ANDA 28 sections
clopidogrel Human Prescription Drug Label 1 31722-902 TABLET, FILM COATED 300 mg ORAL ANDA 28 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 33261-987 TABLET, FILM COATED 75 mg ORAL ANDA 28 sections
Clopidogrel Human Prescription Drug Label 1 33342-060 TABLET 75 mg ORAL ANDA 27 sections
Clopidogrel Human Prescription Drug Label 1 33342-060 TABLET 75 mg ORAL ANDA 27 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 42543-713 TABLET 75 mg ORAL ANDA 27 sections
Clopidogrel HUMAN PRESCRIPTION DRUG LABEL 1 42543-714 TABLET 300 mg ORAL ANDA 27 sections