clonidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| alpha-2 adrenoreceptor agonists | 704 | 4205-90-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.45 | mg | O |
| 0.45 | mg | P |
| 0.10 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.17 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Hosey CM, Chan R, Benet LZ |
| EoM (Fraction excreted unchanged in urine) | 62 % | Hosey CM, Chan R, Benet LZ |
| BA (Bioavailability) | 95 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 3.30 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 4 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.56 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 7.60 hours | Lombardo F, Berellini G, Obach RS |
| S (Water solubility) | 50 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 3, 1974 | FDA | BOEHRINGER INGELHEIM |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Temperature regulation disorder | 399.07 | 9.97 | 171 | 65427 | 5961 | 63417463 |
| Completed suicide | 328.90 | 9.97 | 561 | 65037 | 145112 | 63278312 |
| Food allergy | 301.13 | 9.97 | 172 | 65426 | 11229 | 63412195 |
| Coeliac disease | 280.13 | 9.97 | 171 | 65427 | 12626 | 63410798 |
| Immunodeficiency | 211.41 | 9.97 | 172 | 65426 | 20082 | 63403342 |
| Bradycardia | 193.46 | 9.97 | 303 | 65295 | 72924 | 63350500 |
| Bursitis | 186.00 | 9.97 | 210 | 65388 | 36831 | 63386593 |
| Hypertension | 183.19 | 9.97 | 669 | 64929 | 278634 | 63144790 |
| Hyperhidrosis | 180.02 | 9.97 | 365 | 65233 | 107471 | 63315953 |
| Hypertensive crisis | 164.16 | 9.97 | 132 | 65466 | 15154 | 63408270 |
| Cardiac failure congestive | 161.61 | 9.97 | 319 | 65279 | 92114 | 63331310 |
| Drug withdrawal syndrome | 155.34 | 9.97 | 165 | 65433 | 27029 | 63396395 |
| Pemphigus | 150.64 | 9.97 | 10 | 65588 | 183716 | 63239708 |
| Rash erythematous | 142.76 | 9.97 | 197 | 65401 | 42313 | 63381111 |
| Overdose | 138.61 | 9.97 | 342 | 65256 | 114736 | 63308688 |
| Mental status changes | 135.22 | 9.97 | 185 | 65413 | 39414 | 63384010 |
| Synovitis | 135.05 | 9.97 | 17 | 65581 | 186901 | 63236523 |
| Hand deformity | 132.74 | 9.97 | 8 | 65590 | 159449 | 63263975 |
| Fluid retention | 132.01 | 9.97 | 228 | 65370 | 59458 | 63363966 |
| Glossodynia | 125.11 | 9.97 | 18 | 65580 | 178858 | 63244566 |
| Systemic lupus erythematosus | 119.27 | 9.97 | 34 | 65564 | 208884 | 63214540 |
| Arthropathy | 112.34 | 9.97 | 51 | 65547 | 234741 | 63188683 |
| Blood pressure inadequately controlled | 107.60 | 9.97 | 66 | 65532 | 4912 | 63418512 |
| Application site rash | 103.77 | 9.97 | 51 | 65547 | 2447 | 63420977 |
| Blood pressure increased | 103.35 | 9.97 | 385 | 65213 | 161677 | 63261747 |
| Pericarditis | 99.97 | 9.97 | 10 | 65588 | 131569 | 63291855 |
| Body tinea | 98.26 | 9.97 | 45 | 65553 | 1840 | 63421584 |
| Application site pruritus | 96.94 | 9.97 | 57 | 65541 | 3927 | 63419497 |
| Anti-cyclic citrullinated peptide antibody positive | 96.19 | 9.97 | 6 | 65592 | 116206 | 63307218 |
| Upper respiratory tract infection | 93.68 | 9.97 | 239 | 65359 | 81808 | 63341616 |
| Hypotension | 89.75 | 9.97 | 534 | 65064 | 272070 | 63151354 |
| Maternal exposure during pregnancy | 89.00 | 9.97 | 59 | 65539 | 220003 | 63203421 |
| Neovascularisation | 88.15 | 9.97 | 36 | 65562 | 1109 | 63422315 |
| Nephrogenic systemic fibrosis | 87.40 | 9.97 | 56 | 65542 | 4500 | 63418924 |
| Product adhesion issue | 83.16 | 9.97 | 55 | 65543 | 4664 | 63418760 |
| Alopecia | 82.22 | 9.97 | 139 | 65459 | 337397 | 63086027 |
| Sinus bradycardia | 80.81 | 9.97 | 87 | 65511 | 14464 | 63408960 |
| Inhibitory drug interaction | 80.67 | 9.97 | 45 | 65553 | 2804 | 63420620 |
| Wound | 80.37 | 9.97 | 34 | 65564 | 163229 | 63260195 |
| Cerebrovascular accident | 80.32 | 9.97 | 270 | 65328 | 107754 | 63315670 |
| Joint swelling | 78.83 | 9.97 | 136 | 65462 | 327530 | 63095894 |
| Poisoning | 78.00 | 9.97 | 83 | 65515 | 13617 | 63409807 |
| Paradoxical drug reaction | 74.65 | 9.97 | 49 | 65549 | 4103 | 63419321 |
| Hypertensive encephalopathy | 73.90 | 9.97 | 27 | 65571 | 611 | 63422813 |
| Application site erythema | 72.50 | 9.97 | 51 | 65547 | 4784 | 63418640 |
| Constipation | 72.30 | 9.97 | 438 | 65160 | 224505 | 63198919 |
| Infection susceptibility increased | 71.84 | 9.97 | 45 | 65553 | 3476 | 63419948 |
| Withdrawal syndrome | 69.12 | 9.97 | 94 | 65504 | 19903 | 63403521 |
| Drug intolerance | 68.99 | 9.97 | 134 | 65464 | 308527 | 63114897 |
| Therapeutic product effect decreased | 67.63 | 9.97 | 60 | 65538 | 193127 | 63230297 |
| Somnolence | 63.27 | 9.97 | 357 | 65241 | 178328 | 63245096 |
| Withdrawal hypertension | 63.24 | 9.97 | 17 | 65581 | 131 | 63423293 |
| Discomfort | 62.26 | 9.97 | 49 | 65549 | 167325 | 63256099 |
| Accidental exposure to product by child | 60.68 | 9.97 | 28 | 65570 | 1165 | 63422259 |
| Application site irritation | 58.91 | 9.97 | 31 | 65567 | 1719 | 63421705 |
| Duodenal ulcer perforation | 58.17 | 9.97 | 10 | 65588 | 87199 | 63336225 |
| Rheumatoid factor positive | 57.82 | 9.97 | 9 | 65589 | 84397 | 63339027 |
| Swelling | 56.91 | 9.97 | 125 | 65473 | 275253 | 63148171 |
| Glucose tolerance impaired | 56.60 | 9.97 | 50 | 65548 | 6527 | 63416897 |
| Toxicity to various agents | 55.50 | 9.97 | 441 | 65157 | 246809 | 63176615 |
| Folliculitis | 54.31 | 9.97 | 5 | 65593 | 70312 | 63353112 |
| Abdominal discomfort | 53.75 | 9.97 | 162 | 65436 | 320723 | 63102701 |
| Muscle injury | 52.24 | 9.97 | 4 | 65594 | 65341 | 63358083 |
| Sedation | 50.59 | 9.97 | 119 | 65479 | 38690 | 63384734 |
| Myocardial infarction | 50.58 | 9.97 | 221 | 65377 | 99672 | 63323752 |
| Rash | 50.43 | 9.97 | 356 | 65242 | 560515 | 62862909 |
| Arthralgia | 49.58 | 9.97 | 365 | 65233 | 569345 | 62854079 |
| Acute motor-sensory axonal neuropathy | 48 | 9.97 | 16 | 65582 | 273 | 63423151 |
| Lower respiratory tract infection | 47.62 | 9.97 | 40 | 65558 | 132267 | 63291157 |
| Asthma | 46.54 | 9.97 | 257 | 65341 | 127304 | 63296120 |
| Chronic kidney disease | 46.45 | 9.97 | 127 | 65471 | 45271 | 63378153 |
| Neutropenia | 46.41 | 9.97 | 68 | 65530 | 174937 | 63248487 |
| Product tampering | 45.87 | 9.97 | 17 | 65581 | 401 | 63423023 |
| Unresponsive to stimuli | 45.51 | 9.97 | 105 | 65493 | 33711 | 63389713 |
| Malignant catatonia | 45.23 | 9.97 | 14 | 65584 | 186 | 63423238 |
| Infusion related reaction | 44.74 | 9.97 | 119 | 65479 | 245402 | 63178022 |
| Impaired healing | 43.47 | 9.97 | 26 | 65572 | 102516 | 63320908 |
| Hypertensive emergency | 43.37 | 9.97 | 26 | 65572 | 1856 | 63421568 |
| Cardiac arrest | 43.29 | 9.97 | 200 | 65398 | 92345 | 63331079 |
| Intestinal angioedema | 41.73 | 9.97 | 18 | 65580 | 637 | 63422787 |
| Adulterated product | 41.72 | 9.97 | 14 | 65584 | 244 | 63423180 |
| Irritable bowel syndrome | 40.80 | 9.97 | 17 | 65581 | 82395 | 63341029 |
| Malignant hypertension | 39.45 | 9.97 | 21 | 65577 | 1192 | 63422232 |
| Impaired quality of life | 39.12 | 9.97 | 59 | 65539 | 13724 | 63409700 |
| Poor quality sleep | 38.73 | 9.97 | 72 | 65526 | 19863 | 63403561 |
| Nasopharyngitis | 38.62 | 9.97 | 134 | 65464 | 254123 | 63169301 |
| Hyperlipidaemia | 38.41 | 9.97 | 71 | 65527 | 19500 | 63403924 |
| Infection | 38.12 | 9.97 | 116 | 65482 | 229057 | 63194367 |
| Peritonitis bacterial | 37.87 | 9.97 | 35 | 65563 | 4844 | 63418580 |
| Gastrointestinal disorder | 37.81 | 9.97 | 48 | 65550 | 131191 | 63292233 |
| Suspected suicide | 37.75 | 9.97 | 40 | 65558 | 6528 | 63416896 |
| Anti-neutrophil cytoplasmic antibody positive vasculitis | 37.59 | 9.97 | 28 | 65570 | 2871 | 63420553 |
| Nodal rhythm | 37.39 | 9.97 | 23 | 65575 | 1720 | 63421704 |
| Skin induration | 37.10 | 9.97 | 29 | 65569 | 3194 | 63420230 |
| Sleep disorder due to general medical condition, insomnia type | 37.08 | 9.97 | 5 | 65593 | 52212 | 63371212 |
| Claustrophobia | 37.04 | 9.97 | 19 | 65579 | 999 | 63422425 |
| Hypothermia | 36.94 | 9.97 | 57 | 65541 | 13524 | 63409900 |
| Product substitution issue | 36.51 | 9.97 | 62 | 65536 | 15934 | 63407490 |
| Acute myocardial infarction | 36.04 | 9.97 | 93 | 65505 | 32031 | 63391393 |
| Left ventricular hypertrophy | 35.32 | 9.97 | 35 | 65563 | 5280 | 63418144 |
| Respiratory arrest | 35.08 | 9.97 | 93 | 65505 | 32552 | 63390872 |
| Helicobacter infection | 34.69 | 9.97 | 27 | 65571 | 92758 | 63330666 |
| Malignant neoplasm progression | 34.56 | 9.97 | 21 | 65577 | 82100 | 63341324 |
| Febrile neutropenia | 34.46 | 9.97 | 43 | 65555 | 118406 | 63305018 |
| Back pain | 34.14 | 9.97 | 420 | 65178 | 263725 | 63159699 |
| Purpura | 34.13 | 9.97 | 50 | 65548 | 11335 | 63412089 |
| Sinusitis | 33.38 | 9.97 | 121 | 65477 | 226532 | 63196892 |
| Pulse abnormal | 33.29 | 9.97 | 24 | 65574 | 2340 | 63421084 |
| Miosis | 32.40 | 9.97 | 39 | 65559 | 7314 | 63416110 |
| Cardio-respiratory arrest | 32.15 | 9.97 | 135 | 65463 | 59824 | 63363600 |
| Blister | 31.97 | 9.97 | 53 | 65545 | 129761 | 63293663 |
| Anuria | 31.82 | 9.97 | 51 | 65547 | 12500 | 63410924 |
| Coronary artery disease | 31.56 | 9.97 | 89 | 65509 | 32288 | 63391136 |
| Intentional product misuse | 31.00 | 9.97 | 135 | 65463 | 60782 | 63362642 |
| Skin hypertrophy | 29.62 | 9.97 | 26 | 65572 | 3365 | 63420059 |
| Medical device site pain | 29.45 | 9.97 | 10 | 65588 | 181 | 63423243 |
| Psoriatic arthropathy | 29.02 | 9.97 | 31 | 65567 | 91489 | 63331935 |
| Contraindicated product administered | 28.97 | 9.97 | 121 | 65477 | 217527 | 63205897 |
| Respiratory moniliasis | 28.90 | 9.97 | 10 | 65588 | 192 | 63423232 |
| Skin disorder | 28.66 | 9.97 | 81 | 65517 | 29426 | 63393998 |
| Lethargy | 28.41 | 9.97 | 124 | 65474 | 55883 | 63367541 |
| Extrapyramidal disorder | 28.38 | 9.97 | 50 | 65548 | 13234 | 63410190 |
| Anaesthesia | 27.87 | 9.97 | 12 | 65586 | 423 | 63423001 |
| Condition aggravated | 27.60 | 9.97 | 274 | 65324 | 401943 | 63021481 |
| Musculoskeletal stiffness | 27.55 | 9.97 | 98 | 65500 | 184520 | 63238904 |
| Basal ganglion degeneration | 27.53 | 9.97 | 12 | 65586 | 436 | 63422988 |
| Bone density decreased | 27.42 | 9.97 | 52 | 65546 | 14560 | 63408864 |
| Interstitial lung disease | 27.23 | 9.97 | 15 | 65583 | 61893 | 63361531 |
| Agitation | 27.10 | 9.97 | 128 | 65470 | 59629 | 63363795 |
| Tissue infiltration | 26.60 | 9.97 | 13 | 65585 | 616 | 63422808 |
| Erythema | 26.51 | 9.97 | 288 | 65310 | 175463 | 63247961 |
| Abortion spontaneous | 26.32 | 9.97 | 8 | 65590 | 47187 | 63376237 |
| Implant site extravasation | 26.29 | 9.97 | 12 | 65586 | 487 | 63422937 |
| Epilepsy with myoclonic-atonic seizures | 25.93 | 9.97 | 8 | 65590 | 105 | 63423319 |
| Primary hyperaldosteronism | 25.81 | 9.97 | 7 | 65591 | 56 | 63423368 |
| Urinary incontinence | 25.54 | 9.97 | 82 | 65516 | 31932 | 63391492 |
| Blood aldosterone increased | 25.04 | 9.97 | 9 | 65589 | 194 | 63423230 |
| Accidental overdose | 24.63 | 9.97 | 66 | 65532 | 23243 | 63400181 |
| Rheumatic fever | 24.60 | 9.97 | 7 | 65591 | 43104 | 63380320 |
| Drug dependence | 23.57 | 9.97 | 67 | 65531 | 24416 | 63399008 |
| Encephalomalacia | 23.31 | 9.97 | 11 | 65587 | 482 | 63422942 |
| Retrograde amnesia | 23.16 | 9.97 | 11 | 65587 | 489 | 63422935 |
| Sympathomimetic effect | 22.90 | 9.97 | 7 | 65591 | 89 | 63423335 |
| Drug ineffective for unapproved indication | 22.57 | 9.97 | 82 | 65516 | 33981 | 63389443 |
| Prescribed overdose | 22.45 | 9.97 | 82 | 65516 | 34071 | 63389353 |
| Respiratory depression | 22.34 | 9.97 | 46 | 65552 | 13669 | 63409755 |
| Medication error | 22.27 | 9.97 | 110 | 65488 | 52174 | 63371250 |
| Drug ineffective | 22.12 | 9.97 | 870 | 64728 | 1043895 | 62379529 |
| Renin decreased | 21.77 | 9.97 | 7 | 65591 | 106 | 63423318 |
| Leukopenia | 21.50 | 9.97 | 29 | 65569 | 77261 | 63346163 |
| Diarrhoea | 20.98 | 9.97 | 571 | 65027 | 714795 | 62708629 |
| Apnoea | 20.89 | 9.97 | 33 | 65565 | 7989 | 63415435 |
| Norepinephrine increased | 20.67 | 9.97 | 6 | 65592 | 63 | 63423361 |
| Depressed level of consciousness | 20.61 | 9.97 | 122 | 65476 | 61956 | 63361468 |
| Somatic symptom disorder | 20.49 | 9.97 | 19 | 65579 | 2641 | 63420783 |
| Swollen joint count increased | 20.30 | 9.97 | 6 | 65592 | 36048 | 63387376 |
| Loss of personal independence in daily activities | 20.19 | 9.97 | 44 | 65554 | 97246 | 63326178 |
| Application site papules | 19.94 | 9.97 | 6 | 65592 | 72 | 63423352 |
| Application site pain | 19.78 | 9.97 | 23 | 65575 | 4159 | 63419265 |
| Pulse absent | 19.70 | 9.97 | 26 | 65572 | 5348 | 63418076 |
| Ill-defined disorder | 19.55 | 9.97 | 34 | 65564 | 81721 | 63341703 |
| Medical device site discharge | 19.54 | 9.97 | 5 | 65593 | 31 | 63423393 |
| C-reactive protein increased | 19.52 | 9.97 | 43 | 65555 | 94664 | 63328760 |
| Injection site erythema | 19.52 | 9.97 | 35 | 65563 | 83139 | 63340285 |
| Osteonecrosis of jaw | 19.50 | 9.97 | 6 | 65592 | 35117 | 63388307 |
| White blood cell count decreased | 19.34 | 9.97 | 76 | 65522 | 139028 | 63284396 |
| Atrioventricular block second degree | 19.31 | 9.97 | 22 | 65576 | 3892 | 63419532 |
| Coma scale abnormal | 18.99 | 9.97 | 25 | 65573 | 5128 | 63418296 |
| Impaired work ability | 18.99 | 9.97 | 50 | 65548 | 17425 | 63405999 |
| Hypoventilation | 18.99 | 9.97 | 24 | 65574 | 4730 | 63418694 |
| Myocardial ischaemia | 18.49 | 9.97 | 41 | 65557 | 12818 | 63410606 |
| Gastrointestinal tract mucosal pigmentation | 18.40 | 9.97 | 10 | 65588 | 592 | 63422832 |
| Arthritis | 18.32 | 9.97 | 60 | 65538 | 115861 | 63307563 |
| Implant site infection | 18.31 | 9.97 | 12 | 65586 | 1002 | 63422422 |
| Renal failure | 18.29 | 9.97 | 194 | 65404 | 117458 | 63305966 |
| Dialysis | 18.21 | 9.97 | 36 | 65562 | 10391 | 63413033 |
| Uterine enlargement | 18.14 | 9.97 | 13 | 65585 | 1255 | 63422169 |
| Anhedonia | 18.10 | 9.97 | 37 | 65561 | 10937 | 63412487 |
| Foetal death | 18.09 | 9.97 | 37 | 65561 | 10943 | 63412481 |
| Pulmonary renal syndrome | 18.06 | 9.97 | 9 | 65589 | 445 | 63422979 |
| Application site discolouration | 18.04 | 9.97 | 11 | 65587 | 810 | 63422614 |
| Neutrophil count decreased | 18.00 | 9.97 | 19 | 65579 | 56387 | 63367037 |
| Page kidney | 17.97 | 9.97 | 4 | 65594 | 12 | 63423412 |
| Pyrexia | 17.81 | 9.97 | 361 | 65237 | 470117 | 62953307 |
| Disease progression | 17.75 | 9.97 | 66 | 65532 | 122692 | 63300732 |
| Hip arthroplasty | 17.63 | 9.97 | 14 | 65584 | 47632 | 63375792 |
| Pernicious anaemia | 17.34 | 9.97 | 10 | 65588 | 664 | 63422760 |
| Peripheral swelling | 17.05 | 9.97 | 184 | 65414 | 265758 | 63157666 |
| Blood pressure abnormal | 17.04 | 9.97 | 44 | 65554 | 15154 | 63408270 |
| Vascular stenosis | 16.92 | 9.97 | 8 | 65590 | 352 | 63423072 |
| Hypertrichosis | 16.90 | 9.97 | 12 | 65586 | 1142 | 63422282 |
| Gamma-glutamyltransferase increased | 16.87 | 9.97 | 7 | 65591 | 34024 | 63389400 |
| Inguinal hernia | 16.76 | 9.97 | 15 | 65583 | 1992 | 63421432 |
| Seizure | 16.72 | 9.97 | 210 | 65388 | 132424 | 63291000 |
| Klebsiella infection | 16.71 | 9.97 | 31 | 65567 | 8535 | 63414889 |
| Application site vesicles | 16.71 | 9.97 | 13 | 65585 | 1422 | 63422002 |
| Human herpesvirus 6 infection reactivation | 16.63 | 9.97 | 8 | 65590 | 366 | 63423058 |
| Loss of consciousness | 16.63 | 9.97 | 191 | 65407 | 117930 | 63305494 |
| Cerebral ischaemia | 16.59 | 9.97 | 27 | 65571 | 6701 | 63416723 |
| Knee arthroplasty | 16.48 | 9.97 | 19 | 65579 | 54187 | 63369237 |
| Focal segmental glomerulosclerosis | 16.45 | 9.97 | 13 | 65585 | 1455 | 63421969 |
| Hyperreflexia | 16.27 | 9.97 | 25 | 65573 | 5909 | 63417515 |
| Renal transplant failure | 16.21 | 9.97 | 10 | 65588 | 752 | 63422672 |
| Glomerulonephritis rapidly progressive | 16.10 | 9.97 | 11 | 65587 | 984 | 63422440 |
| Hyperlactacidaemia | 15.76 | 9.97 | 17 | 65581 | 2832 | 63420592 |
| Medical device site erythema | 15.75 | 9.97 | 4 | 65594 | 24 | 63423400 |
| Change in seizure presentation | 15.70 | 9.97 | 8 | 65590 | 415 | 63423009 |
| Tachyphylaxis | 15.69 | 9.97 | 7 | 65591 | 269 | 63423155 |
| Brain injury | 15.68 | 9.97 | 27 | 65571 | 7016 | 63416408 |
| Pulmonary fibrosis | 15.63 | 9.97 | 11 | 65587 | 39798 | 63383626 |
| Cardiac hypertrophy | 15.61 | 9.97 | 11 | 65587 | 1034 | 63422390 |
| Neurological symptom | 15.35 | 9.97 | 24 | 65574 | 5759 | 63417665 |
| Human ehrlichiosis | 15.29 | 9.97 | 6 | 65592 | 166 | 63423258 |
| Posterior reversible encephalopathy syndrome | 15.29 | 9.97 | 46 | 65552 | 17299 | 63406125 |
| Intentional product use issue | 15.26 | 9.97 | 74 | 65524 | 127818 | 63295606 |
| Iliac artery stenosis | 15.24 | 9.97 | 5 | 65593 | 81 | 63423343 |
| Haematochezia | 14.98 | 9.97 | 20 | 65578 | 53524 | 63369900 |
| Basal ganglia haemorrhage | 14.98 | 9.97 | 9 | 65589 | 645 | 63422779 |
| Alanine aminotransferase increased | 14.87 | 9.97 | 56 | 65542 | 103714 | 63319710 |
| Normochromic normocytic anaemia | 14.83 | 9.97 | 21 | 65577 | 4615 | 63418809 |
| Device expulsion | 14.59 | 9.97 | 9 | 65589 | 34913 | 63388511 |
| Off label use | 14.56 | 9.97 | 560 | 65038 | 673902 | 62749522 |
| Sinus arrhythmia | 14.30 | 9.97 | 12 | 65586 | 1461 | 63421963 |
| Arteriospasm coronary | 14.24 | 9.97 | 19 | 65579 | 3949 | 63419475 |
| Therapeutic drug monitoring analysis incorrectly performed | 14.22 | 9.97 | 7 | 65591 | 337 | 63423087 |
| Rhinorrhoea | 14.16 | 9.97 | 29 | 65569 | 65548 | 63357876 |
| Liver disorder | 14.08 | 9.97 | 21 | 65577 | 53666 | 63369758 |
| Mood swings | 13.89 | 9.97 | 46 | 65552 | 18202 | 63405222 |
| Hyperaesthesia | 13.64 | 9.97 | 30 | 65568 | 9328 | 63414096 |
| Hepatic function abnormal | 13.64 | 9.97 | 11 | 65587 | 37131 | 63386293 |
| Feeling abnormal | 13.53 | 9.97 | 222 | 65376 | 148170 | 63275254 |
| Pain in jaw | 13.49 | 9.97 | 15 | 65583 | 43481 | 63379943 |
| Aggression | 13.45 | 9.97 | 54 | 65544 | 23444 | 63399980 |
| Systolic dysfunction | 13.45 | 9.97 | 12 | 65586 | 1587 | 63421837 |
| Mobility decreased | 13.38 | 9.97 | 72 | 65526 | 121087 | 63302337 |
| Paranoia | 13.29 | 9.97 | 34 | 65564 | 11645 | 63411779 |
| Tremor | 13.25 | 9.97 | 201 | 65397 | 132038 | 63291386 |
| Patent ductus arteriosus | 13.23 | 9.97 | 19 | 65579 | 4231 | 63419193 |
| Device programming error | 13.22 | 9.97 | 5 | 65593 | 125 | 63423299 |
| Haemorrhage intracranial | 13.19 | 9.97 | 37 | 65561 | 13382 | 63410042 |
| Neoplasm progression | 13.11 | 9.97 | 11 | 65587 | 36417 | 63387007 |
| Psychogenic seizure | 12.87 | 9.97 | 12 | 65586 | 1680 | 63421744 |
| Emotional distress | 12.82 | 9.97 | 67 | 65531 | 32482 | 63390942 |
| Intercepted medication error | 12.82 | 9.97 | 8 | 65590 | 614 | 63422810 |
| End stage renal disease | 12.78 | 9.97 | 24 | 65574 | 6669 | 63416755 |
| Device infusion issue | 12.77 | 9.97 | 13 | 65585 | 2025 | 63421399 |
| Skin fibrosis | 12.54 | 9.97 | 9 | 65589 | 871 | 63422553 |
| Injection site pruritus | 12.47 | 9.97 | 17 | 65581 | 45099 | 63378325 |
| Hypertensive heart disease | 12.47 | 9.97 | 14 | 65584 | 2438 | 63420986 |
| Femur fracture | 12.30 | 9.97 | 15 | 65583 | 41741 | 63381683 |
| Chest pain | 12.28 | 9.97 | 301 | 65297 | 215658 | 63207766 |
| Product quality issue | 12.23 | 9.97 | 71 | 65527 | 35794 | 63387630 |
| BRASH syndrome | 12.18 | 9.97 | 7 | 65591 | 462 | 63422962 |
| Injection site abscess | 12.13 | 9.97 | 10 | 65588 | 1188 | 63422236 |
| Exposure via ingestion | 12.12 | 9.97 | 15 | 65583 | 2894 | 63420530 |
| Trichoglossia | 12.11 | 9.97 | 6 | 65592 | 293 | 63423131 |
| Drug abuser | 12.06 | 9.97 | 15 | 65583 | 2908 | 63420516 |
| Fibrosis | 11.97 | 9.97 | 18 | 65580 | 4174 | 63419250 |
| Colitis ulcerative | 11.95 | 9.97 | 6 | 65592 | 26085 | 63397339 |
| Left atrial dilatation | 11.90 | 9.97 | 12 | 65586 | 1849 | 63421575 |
| Akathisia | 11.87 | 9.97 | 28 | 65570 | 9118 | 63414306 |
| Kidney fibrosis | 11.79 | 9.97 | 12 | 65586 | 1869 | 63421555 |
| Hypernatraemia | 11.79 | 9.97 | 25 | 65573 | 7584 | 63415840 |
| Anion gap increased | 11.78 | 9.97 | 12 | 65586 | 1870 | 63421554 |
| Atrioventricular block | 11.70 | 9.97 | 25 | 65573 | 7622 | 63415802 |
| Suicidal ideation | 11.68 | 9.97 | 107 | 65491 | 62314 | 63361110 |
| Acute lung injury | 11.67 | 9.97 | 11 | 65587 | 1560 | 63421864 |
| Left ventricular failure | 11.63 | 9.97 | 21 | 65577 | 5666 | 63417758 |
| Hypertensive urgency | 11.60 | 9.97 | 6 | 65592 | 321 | 63423103 |
| Live birth | 11.58 | 9.97 | 6 | 65592 | 25624 | 63397800 |
| Implant site haematoma | 11.50 | 9.97 | 4 | 65594 | 78 | 63423346 |
| Cerebellar atrophy | 11.47 | 9.97 | 8 | 65590 | 740 | 63422684 |
| Cellulitis | 11.30 | 9.97 | 132 | 65466 | 81826 | 63341598 |
| Application site haematoma | 11.29 | 9.97 | 3 | 65595 | 22 | 63423402 |
| Blood glucose increased | 11.15 | 9.97 | 134 | 65464 | 83622 | 63339802 |
| Headache | 11.14 | 9.97 | 778 | 64820 | 632463 | 62790961 |
| Melaena | 11.14 | 9.97 | 9 | 65589 | 30356 | 63393068 |
| Pneumonia respiratory syncytial viral | 11.13 | 9.97 | 9 | 65589 | 1041 | 63422383 |
| Medical device site swelling | 11.06 | 9.97 | 3 | 65595 | 24 | 63423400 |
| Factitious disorder | 11.05 | 9.97 | 4 | 65594 | 88 | 63423336 |
| Daydreaming | 11.01 | 9.97 | 6 | 65592 | 357 | 63423067 |
| Monoplegia | 10.99 | 9.97 | 15 | 65583 | 3186 | 63420238 |
| Drug screen positive | 10.97 | 9.97 | 16 | 65582 | 3613 | 63419811 |
| Drug dependence, antepartum | 10.85 | 9.97 | 3 | 65595 | 26 | 63423398 |
| Infusion site mass | 10.85 | 9.97 | 12 | 65586 | 2056 | 63421368 |
| Fanconi syndrome | 10.83 | 9.97 | 10 | 65588 | 1382 | 63422042 |
| Joint contracture | 10.81 | 9.97 | 11 | 65587 | 1713 | 63421711 |
| Spinal pain | 10.79 | 9.97 | 34 | 65564 | 13105 | 63410319 |
| Electrocardiogram abnormal | 10.74 | 9.97 | 27 | 65571 | 9152 | 63414272 |
| Macular degeneration | 10.58 | 9.97 | 6 | 65592 | 24370 | 63399054 |
| SJS-TEN overlap | 10.56 | 9.97 | 6 | 65592 | 387 | 63423037 |
| Joint injury | 10.56 | 9.97 | 9 | 65589 | 29563 | 63393861 |
| Labile blood pressure | 10.47 | 9.97 | 11 | 65587 | 1778 | 63421646 |
| Blood potassium increased | 10.42 | 9.97 | 42 | 65556 | 18267 | 63405157 |
| Glomerulonephritis | 10.38 | 9.97 | 11 | 65587 | 1795 | 63421629 |
| Alcoholism | 10.32 | 9.97 | 11 | 65587 | 1807 | 63421617 |
| Implant site hypersensitivity | 10.29 | 9.97 | 3 | 65595 | 32 | 63423392 |
| Macroangiopathy | 10.22 | 9.97 | 4 | 65594 | 110 | 63423314 |
| Hypervolaemia | 10.18 | 9.97 | 57 | 65541 | 28356 | 63395068 |
| Inflammation | 10.17 | 9.97 | 47 | 65551 | 82226 | 63341198 |
| Pruritus | 10.16 | 9.97 | 290 | 65308 | 361163 | 63062261 |
| Enterococcal infection | 10.15 | 9.97 | 24 | 65574 | 7824 | 63415600 |
| Neurological decompensation | 10.04 | 9.97 | 13 | 65585 | 2625 | 63420799 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Completed suicide | 229.73 | 11.35 | 418 | 41605 | 97750 | 34817158 |
| Drug withdrawal syndrome | 208.00 | 11.35 | 180 | 41843 | 19654 | 34895254 |
| Aggression | 161.35 | 11.35 | 216 | 41807 | 38748 | 34876160 |
| Bradycardia | 157.45 | 11.35 | 306 | 41717 | 75112 | 34839796 |
| Withdrawal hypertension | 129.51 | 11.35 | 33 | 41990 | 168 | 34914740 |
| Respiratory depression | 124.86 | 11.35 | 124 | 41899 | 16121 | 34898787 |
| Drug dependence | 98.29 | 11.35 | 133 | 41890 | 24084 | 34890824 |
| Hypertensive crisis | 88.84 | 11.35 | 78 | 41945 | 8673 | 34906235 |
| Hypertension | 86.69 | 11.35 | 359 | 41664 | 136084 | 34778824 |
| Withdrawal syndrome | 81.13 | 11.35 | 87 | 41936 | 12368 | 34902540 |
| Victim of child abuse | 79.94 | 11.35 | 33 | 41990 | 894 | 34914014 |
| Oppositional defiant disorder | 77.61 | 11.35 | 28 | 41995 | 521 | 34914387 |
| Hypotension | 73.73 | 11.35 | 487 | 41536 | 221162 | 34693746 |
| Decreased eye contact | 72.81 | 11.35 | 26 | 41997 | 469 | 34914439 |
| Choreoathetosis | 69.11 | 11.35 | 31 | 41992 | 1033 | 34913875 |
| Application site rash | 68.83 | 11.35 | 29 | 41994 | 828 | 34914080 |
| Blood pressure inadequately controlled | 67.10 | 11.35 | 41 | 41982 | 2599 | 34912309 |
| Obesity | 63.66 | 11.35 | 78 | 41945 | 12800 | 34902108 |
| Epidural lipomatosis | 59.95 | 11.35 | 28 | 41995 | 1026 | 34913882 |
| Accidental exposure to product by child | 59.46 | 11.35 | 31 | 41992 | 1445 | 34913463 |
| Agitation | 58.88 | 11.35 | 177 | 41846 | 57222 | 34857686 |
| Anxiety | 57.97 | 11.35 | 255 | 41768 | 99173 | 34815735 |
| Sedation | 57.51 | 11.35 | 96 | 41927 | 20910 | 34893998 |
| Sinus bradycardia | 56.91 | 11.35 | 74 | 41949 | 12889 | 34902019 |
| Cardiac failure congestive | 55.90 | 11.35 | 223 | 41800 | 83047 | 34831861 |
| Product substitution issue | 54.58 | 11.35 | 64 | 41959 | 10031 | 34904877 |
| Miosis | 54.15 | 11.35 | 62 | 41961 | 9473 | 34905435 |
| Dystonia | 52.50 | 11.35 | 65 | 41958 | 10780 | 34904128 |
| Blood prolactin increased | 51.68 | 11.35 | 30 | 41993 | 1730 | 34913178 |
| Mental status changes | 51.54 | 11.35 | 130 | 41893 | 37953 | 34876955 |
| Somnolence | 51.01 | 11.35 | 266 | 41757 | 110850 | 34804058 |
| Blood pressure increased | 50.62 | 11.35 | 225 | 41798 | 87877 | 34827031 |
| Overweight | 49.70 | 11.35 | 30 | 41993 | 1860 | 34913048 |
| Crying | 49.25 | 11.35 | 47 | 41976 | 5815 | 34909093 |
| Trismus | 49.15 | 11.35 | 33 | 41990 | 2462 | 34912446 |
| Psychomotor hyperactivity | 48.73 | 11.35 | 59 | 41964 | 9563 | 34905345 |
| Febrile neutropenia | 48.31 | 11.35 | 56 | 41967 | 136793 | 34778115 |
| Homicidal ideation | 46.99 | 11.35 | 33 | 41990 | 2649 | 34912259 |
| Bruxism | 46.81 | 11.35 | 28 | 41995 | 1707 | 34913201 |
| Neuroleptic malignant syndrome | 46.50 | 11.35 | 80 | 41943 | 17854 | 34897054 |
| Hypertensive emergency | 45.24 | 11.35 | 23 | 42000 | 1017 | 34913891 |
| Juvenile idiopathic arthritis | 44.51 | 11.35 | 28 | 41995 | 1869 | 34913039 |
| Product adhesion issue | 43.63 | 11.35 | 26 | 41997 | 1574 | 34913334 |
| Nephrogenic systemic fibrosis | 43.28 | 11.35 | 37 | 41986 | 3968 | 34910940 |
| Lethargy | 41.40 | 11.35 | 126 | 41897 | 40996 | 34873912 |
| Toxic epidermal necrolysis | 40.50 | 11.35 | 84 | 41939 | 21562 | 34893346 |
| Serotonin syndrome | 40.44 | 11.35 | 80 | 41943 | 19853 | 34895055 |
| Interstitial lung disease | 40.40 | 11.35 | 14 | 42009 | 65268 | 34849640 |
| Irritability | 39.56 | 11.35 | 90 | 41933 | 24600 | 34890308 |
| Pneumonia | 39.38 | 11.35 | 265 | 41758 | 362362 | 34552546 |
| Toxicity to various agents | 39.08 | 11.35 | 390 | 41633 | 199972 | 34714936 |
| Suicidal ideation | 39.03 | 11.35 | 122 | 41901 | 40266 | 34874642 |
| Thrombocytopenia | 38.84 | 11.35 | 81 | 41942 | 156166 | 34758742 |
| Cerebrovascular accident | 38.19 | 11.35 | 202 | 41821 | 84609 | 34830299 |
| Cardiac arrest | 37.95 | 11.35 | 221 | 41802 | 95938 | 34818970 |
| Malignant catatonia | 36.48 | 11.35 | 13 | 42010 | 233 | 34914675 |
| Product prescribing error | 36.10 | 11.35 | 83 | 41940 | 22844 | 34892064 |
| Application site pruritus | 35.71 | 11.35 | 22 | 42001 | 1415 | 34913493 |
| Peritonitis bacterial | 35.15 | 11.35 | 40 | 41983 | 6070 | 34908838 |
| Catatonia | 34.31 | 11.35 | 36 | 41987 | 4989 | 34909919 |
| Device failure | 34.29 | 11.35 | 26 | 41997 | 2350 | 34912558 |
| Respiratory arrest | 34.12 | 11.35 | 92 | 41931 | 27951 | 34886957 |
| Dyskinesia | 34.04 | 11.35 | 80 | 41943 | 22333 | 34892575 |
| Emotional distress | 33.79 | 11.35 | 63 | 41960 | 14963 | 34899945 |
| Aplastic anaemia | 32.96 | 11.35 | 49 | 41974 | 9667 | 34905241 |
| Neutropenia | 32.81 | 11.35 | 89 | 41934 | 156689 | 34758219 |
| Malignant neoplasm progression | 32.17 | 11.35 | 35 | 41988 | 88011 | 34826897 |
| Hepatic function abnormal | 32.14 | 11.35 | 7 | 42016 | 44356 | 34870552 |
| Sedation complication | 31.45 | 11.35 | 22 | 42001 | 1755 | 34913153 |
| Tic | 30.76 | 11.35 | 23 | 42000 | 2035 | 34912873 |
| Suspected suicide | 30.62 | 11.35 | 33 | 41990 | 4715 | 34910193 |
| Pancytopenia | 30.37 | 11.35 | 42 | 41981 | 95115 | 34819793 |
| Hypotonia | 30.15 | 11.35 | 42 | 41981 | 7811 | 34907097 |
| Tardive dyskinesia | 30.13 | 11.35 | 36 | 41987 | 5754 | 34909154 |
| Pyrexia | 30.12 | 11.35 | 256 | 41767 | 332757 | 34582151 |
| Child abuse | 29.53 | 11.35 | 13 | 42010 | 414 | 34914494 |
| Overdose | 29.50 | 11.35 | 199 | 41824 | 90860 | 34824048 |
| Intestinal pseudo-obstruction | 29.36 | 11.35 | 21 | 42002 | 1735 | 34913173 |
| Unresponsive to stimuli | 29.18 | 11.35 | 86 | 41937 | 27483 | 34887425 |
| Accidental overdose | 28.55 | 11.35 | 70 | 41953 | 20070 | 34894838 |
| Autonomic nervous system imbalance | 28.45 | 11.35 | 24 | 41999 | 2527 | 34912381 |
| Application site erythema | 28.18 | 11.35 | 23 | 42000 | 2313 | 34912595 |
| Hyperaesthesia | 27.81 | 11.35 | 31 | 41992 | 4599 | 34910309 |
| Anal inflammation | 27.56 | 11.35 | 18 | 42005 | 1282 | 34913626 |
| Application site irritation | 26.30 | 11.35 | 14 | 42009 | 681 | 34914227 |
| Affect lability | 26.25 | 11.35 | 27 | 41996 | 3656 | 34911252 |
| Kidney transplant rejection | 25.70 | 11.35 | 38 | 41985 | 7459 | 34907449 |
| Accelerated hypertension | 25.04 | 11.35 | 10 | 42013 | 248 | 34914660 |
| Drug ineffective for unapproved indication | 24.17 | 11.35 | 73 | 41950 | 23642 | 34891266 |
| General physical health deterioration | 23.80 | 11.35 | 77 | 41946 | 128192 | 34786716 |
| SARS-CoV-2 test negative | 23.79 | 11.35 | 15 | 42008 | 1005 | 34913903 |
| Inadequate analgesia | 23.39 | 11.35 | 23 | 42000 | 2952 | 34911956 |
| Natural killer cell count decreased | 22.90 | 11.35 | 4 | 42019 | 0 | 34914908 |
| Labile hypertension | 22.77 | 11.35 | 7 | 42016 | 77 | 34914831 |
| Galactorrhoea | 22.68 | 11.35 | 11 | 42012 | 439 | 34914469 |
| Injury | 22.34 | 11.35 | 65 | 41958 | 20622 | 34894286 |
| Rheumatoid arthritis | 22.31 | 11.35 | 9 | 42014 | 38229 | 34876679 |
| Corneal reflex decreased | 21.41 | 11.35 | 8 | 42015 | 165 | 34914743 |
| Paradoxical drug reaction | 21.10 | 11.35 | 23 | 42000 | 3328 | 34911580 |
| Insomnia | 21.05 | 11.35 | 204 | 41819 | 103703 | 34811205 |
| Platelet count decreased | 20.75 | 11.35 | 74 | 41949 | 119643 | 34795265 |
| Hyperkinesia | 20.48 | 11.35 | 17 | 42006 | 1751 | 34913157 |
| Product preparation issue | 20.41 | 11.35 | 10 | 42013 | 408 | 34914500 |
| Stress cardiomyopathy | 20.19 | 11.35 | 18 | 42005 | 2041 | 34912867 |
| Abnormal behaviour | 20.16 | 11.35 | 71 | 41952 | 24898 | 34890010 |
| Anger | 19.79 | 11.35 | 44 | 41979 | 11840 | 34903068 |
| Product administered to patient of inappropriate age | 19.71 | 11.35 | 22 | 42001 | 3269 | 34911639 |
| Coordination abnormal | 19.68 | 11.35 | 34 | 41989 | 7610 | 34907298 |
| Drug screen positive | 19.67 | 11.35 | 24 | 41999 | 3919 | 34910989 |
| Tourette's disorder | 19.05 | 11.35 | 6 | 42017 | 72 | 34914836 |
| Speech disorder | 19.01 | 11.35 | 71 | 41952 | 25615 | 34889293 |
| Neutrophil count decreased | 19.01 | 11.35 | 20 | 42003 | 51084 | 34863824 |
| Poisoning | 18.96 | 11.35 | 44 | 41979 | 12182 | 34902726 |
| Medical device site pain | 18.90 | 11.35 | 6 | 42017 | 74 | 34914834 |
| Fibrosis | 18.82 | 11.35 | 19 | 42004 | 2517 | 34912391 |
| Pain | 18.82 | 11.35 | 348 | 41675 | 204327 | 34710581 |
| Attention deficit hyperactivity disorder | 18.67 | 11.35 | 19 | 42004 | 2540 | 34912368 |
| Drug tolerance | 18.53 | 11.35 | 20 | 42003 | 2862 | 34912046 |
| Axillary pain | 18.22 | 11.35 | 9 | 42014 | 374 | 34914534 |
| Respiratory rate decreased | 18.10 | 11.35 | 18 | 42005 | 2341 | 34912567 |
| Disease progression | 17.94 | 11.35 | 68 | 41955 | 108009 | 34806899 |
| Diarrhoea | 17.87 | 11.35 | 346 | 41677 | 389566 | 34525342 |
| Prostate cancer | 17.79 | 11.35 | 13 | 42010 | 39636 | 34875272 |
| Implant site extravasation | 17.70 | 11.35 | 9 | 42014 | 398 | 34914510 |
| Inflammation | 17.61 | 11.35 | 6 | 42017 | 28289 | 34886619 |
| Product prescribing issue | 17.42 | 11.35 | 17 | 42006 | 2162 | 34912746 |
| Anhedonia | 17.30 | 11.35 | 32 | 41991 | 7553 | 34907355 |
| Infection | 17.26 | 11.35 | 54 | 41969 | 90861 | 34824047 |
| Mood altered | 17.05 | 11.35 | 35 | 41988 | 8917 | 34905991 |
| Accidental poisoning | 16.90 | 11.35 | 11 | 42012 | 779 | 34914129 |
| Loss of consciousness | 16.59 | 11.35 | 162 | 41861 | 82505 | 34832403 |
| Poor quality sleep | 16.58 | 11.35 | 33 | 41990 | 8223 | 34906685 |
| Metabolic alkalosis | 16.49 | 11.35 | 14 | 42009 | 1487 | 34913421 |
| Drug ineffective | 16.49 | 11.35 | 688 | 41335 | 456063 | 34458845 |
| Oromandibular dystonia | 15.94 | 11.35 | 9 | 42014 | 492 | 34914416 |
| Brief psychotic disorder with marked stressors | 15.87 | 11.35 | 7 | 42016 | 224 | 34914684 |
| Product use issue | 15.82 | 11.35 | 130 | 41893 | 63086 | 34851822 |
| Cytokine release syndrome | 15.80 | 11.35 | 4 | 42019 | 22873 | 34892035 |
| Reaction to excipient | 15.71 | 11.35 | 9 | 42014 | 506 | 34914402 |
| Cardio-respiratory arrest | 15.67 | 11.35 | 117 | 41906 | 55156 | 34859752 |
| Device power source issue | 15.40 | 11.35 | 8 | 42015 | 370 | 34914538 |
| Streptococcal infection | 15.38 | 11.35 | 24 | 41999 | 4937 | 34909971 |
| Mast cell degranulation present | 15.30 | 11.35 | 5 | 42018 | 68 | 34914840 |
| C-reactive protein increased | 15.22 | 11.35 | 26 | 41997 | 54072 | 34860836 |
| Double inlet left ventricle | 15.15 | 11.35 | 4 | 42019 | 24 | 34914884 |
| Hyponatraemia | 15.08 | 11.35 | 50 | 41973 | 82641 | 34832267 |
| Hyperhidrosis | 15.02 | 11.35 | 148 | 41875 | 75544 | 34839364 |
| Sepsis | 15.02 | 11.35 | 128 | 41895 | 166433 | 34748475 |
| Product compounding quality issue | 15.01 | 11.35 | 4 | 42019 | 25 | 34914883 |
| Myocardial infarction | 14.87 | 11.35 | 216 | 41807 | 120869 | 34794039 |
| Product preparation error | 14.76 | 11.35 | 16 | 42007 | 2301 | 34912607 |
| Metastases to eye | 14.73 | 11.35 | 5 | 42018 | 77 | 34914831 |
| Lower respiratory tract infection | 14.68 | 11.35 | 10 | 42013 | 31627 | 34883281 |
| White blood cell count decreased | 14.61 | 11.35 | 62 | 41961 | 95383 | 34819525 |
| Pneumocystis jirovecii pneumonia | 14.50 | 11.35 | 3 | 42020 | 19707 | 34895201 |
| Drooling | 14.36 | 11.35 | 19 | 42004 | 3363 | 34911545 |
| Arthralgia | 14.31 | 11.35 | 133 | 41890 | 169908 | 34745000 |
| Post transplant distal limb syndrome | 14.23 | 11.35 | 7 | 42016 | 288 | 34914620 |
| Saccadic eye movement | 14.18 | 11.35 | 6 | 42017 | 173 | 34914735 |
| Hypoxic-ischaemic encephalopathy | 14.16 | 11.35 | 22 | 42001 | 4510 | 34910398 |
| Cardiac failure | 14.14 | 11.35 | 59 | 41964 | 91189 | 34823719 |
| Incision site pain | 14.06 | 11.35 | 14 | 42009 | 1824 | 34913084 |
| Impaired gastric emptying | 14.05 | 11.35 | 19 | 42004 | 3434 | 34911474 |
| Renal transplant | 13.99 | 11.35 | 14 | 42009 | 1835 | 34913073 |
| Skin induration | 13.96 | 11.35 | 15 | 42008 | 2136 | 34912772 |
| Pulmonary embolism | 13.92 | 11.35 | 58 | 41965 | 89688 | 34825220 |
| Productive cough | 13.84 | 11.35 | 15 | 42008 | 37798 | 34877110 |
| Transcription medication error | 13.81 | 11.35 | 6 | 42017 | 185 | 34914723 |
| Intentional product misuse | 13.76 | 11.35 | 98 | 41925 | 45513 | 34869395 |
| Univentricular heart | 13.73 | 11.35 | 4 | 42019 | 36 | 34914872 |
| Seizure | 13.65 | 11.35 | 189 | 41834 | 104668 | 34810240 |
| Autoimmune enteropathy | 13.64 | 11.35 | 4 | 42019 | 37 | 34914871 |
| Muscle spasticity | 13.63 | 11.35 | 25 | 41998 | 5863 | 34909045 |
| Device infusion issue | 13.47 | 11.35 | 10 | 42013 | 875 | 34914033 |
| Gastrointestinal tract mucosal pigmentation | 13.46 | 11.35 | 8 | 42015 | 482 | 34914426 |
| COVID-19 | 13.39 | 11.35 | 48 | 41975 | 77502 | 34837406 |
| Skin tightness | 13.39 | 11.35 | 15 | 42008 | 2238 | 34912670 |
| Hydrocele male infected | 13.36 | 11.35 | 4 | 42019 | 40 | 34914868 |
| Drug withdrawal maintenance therapy | 13.30 | 11.35 | 5 | 42018 | 105 | 34914803 |
| Gastric hypomotility | 13.17 | 11.35 | 5 | 42018 | 108 | 34914800 |
| Pulmonary fibrosis | 13.13 | 11.35 | 3 | 42020 | 18393 | 34896515 |
| Sprue-like enteropathy | 13.12 | 11.35 | 8 | 42015 | 505 | 34914403 |
| Skin hypertrophy | 13.11 | 11.35 | 16 | 42007 | 2613 | 34912295 |
| Harlequin syndrome | 13.03 | 11.35 | 3 | 42020 | 9 | 34914899 |
| End stage renal disease | 12.77 | 11.35 | 31 | 41992 | 8830 | 34906078 |
| Septic shock | 12.71 | 11.35 | 44 | 41979 | 71790 | 34843118 |
| Contraindicated product administered | 12.62 | 11.35 | 5 | 42018 | 21476 | 34893432 |
| Product quality issue | 12.53 | 11.35 | 47 | 41976 | 16988 | 34897920 |
| Posterior reversible encephalopathy syndrome | 12.45 | 11.35 | 33 | 41990 | 9921 | 34904987 |
| Accident | 12.41 | 11.35 | 22 | 42001 | 5025 | 34909883 |
| Hypercapnia | 12.39 | 11.35 | 20 | 42003 | 4235 | 34910673 |
| Nephropathy | 12.30 | 11.35 | 24 | 41999 | 5893 | 34909015 |
| Alopecia | 12.27 | 11.35 | 7 | 42016 | 24348 | 34890560 |
| Impulsive behaviour | 12.18 | 11.35 | 14 | 42009 | 2148 | 34912760 |
| Multiple organ dysfunction syndrome | 12.17 | 11.35 | 49 | 41974 | 76517 | 34838391 |
| Liver disorder | 12.17 | 11.35 | 13 | 42010 | 32984 | 34881924 |
| Rash | 11.98 | 11.35 | 192 | 41831 | 222560 | 34692348 |
| Rash maculo-papular | 11.91 | 11.35 | 10 | 42013 | 28441 | 34886467 |
| Hepatitis | 11.86 | 11.35 | 7 | 42016 | 23897 | 34891011 |
| Arthropathy | 11.84 | 11.35 | 9 | 42014 | 26898 | 34888010 |
| Atrioventricular block first degree | 11.81 | 11.35 | 24 | 41999 | 6068 | 34908840 |
| Agranulocytosis | 11.78 | 11.35 | 7 | 42016 | 23814 | 34891094 |
| Mood swings | 11.77 | 11.35 | 28 | 41995 | 7873 | 34907035 |
| Renal artery stenosis | 11.67 | 11.35 | 14 | 42009 | 2247 | 34912661 |
| Drug withdrawal headache | 11.66 | 11.35 | 3 | 42020 | 16 | 34914892 |
| Lymphocele | 11.63 | 11.35 | 11 | 42012 | 1346 | 34913562 |
| Joint contracture | 11.56 | 11.35 | 13 | 42010 | 1948 | 34912960 |
| Hyperbilirubinaemia | 11.52 | 11.35 | 3 | 42020 | 16840 | 34898068 |
| Autism spectrum disorder | 11.50 | 11.35 | 14 | 42009 | 2282 | 34912626 |
| Disseminated intravascular coagulation | 11.38 | 11.35 | 6 | 42017 | 21810 | 34893098 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Completed suicide | 594.01 | 10.24 | 1018 | 88031 | 244749 | 79410590 |
| Temperature regulation disorder | 380.87 | 10.24 | 167 | 88882 | 5686 | 79649653 |
| Bradycardia | 350.16 | 10.24 | 579 | 88470 | 134978 | 79520361 |
| Drug withdrawal syndrome | 324.65 | 10.24 | 286 | 88763 | 34432 | 79620907 |
| Food allergy | 270.68 | 10.24 | 162 | 88887 | 10662 | 79644677 |
| Coeliac disease | 268.68 | 10.24 | 164 | 88885 | 11187 | 79644152 |
| Hypertensive crisis | 265.10 | 10.24 | 205 | 88844 | 20565 | 79634774 |
| Hypertension | 200.98 | 10.24 | 816 | 88233 | 330176 | 79325163 |
| Immunodeficiency | 187.03 | 10.24 | 171 | 88878 | 21597 | 79633742 |
| Cardiac failure congestive | 183.90 | 10.24 | 456 | 88593 | 141946 | 79513393 |
| Mental status changes | 175.40 | 10.24 | 288 | 88761 | 66671 | 79588668 |
| Withdrawal hypertension | 174.20 | 10.24 | 47 | 89002 | 337 | 79655002 |
| Overdose | 172.25 | 10.24 | 524 | 88525 | 183682 | 79471657 |
| Bursitis | 163.54 | 10.24 | 201 | 88848 | 35643 | 79619696 |
| Hyperhidrosis | 158.89 | 10.24 | 449 | 88600 | 151043 | 79504296 |
| Aggression | 155.37 | 10.24 | 235 | 88814 | 50723 | 79604616 |
| Sinus bradycardia | 144.33 | 10.24 | 159 | 88890 | 25088 | 79630251 |
| Withdrawal syndrome | 141.35 | 10.24 | 162 | 88887 | 26692 | 79628647 |
| Respiratory depression | 139.26 | 10.24 | 163 | 88886 | 27467 | 79627872 |
| Hypotension | 134.90 | 10.24 | 897 | 88152 | 439420 | 79215919 |
| Accidental exposure to product by child | 126.71 | 10.24 | 63 | 88986 | 2863 | 79652476 |
| Synovitis | 117.19 | 10.24 | 15 | 89034 | 150719 | 79504620 |
| Toxicity to various agents | 115.64 | 10.24 | 836 | 88213 | 420704 | 79234635 |
| Somnolence | 108.60 | 10.24 | 541 | 88508 | 238440 | 79416899 |
| Cerebrovascular accident | 108.02 | 10.24 | 400 | 88649 | 154892 | 79500447 |
| Drug dependence | 96.97 | 10.24 | 168 | 88881 | 40601 | 79614738 |
| Poisoning | 96.85 | 10.24 | 130 | 88919 | 25142 | 79630197 |
| Miosis | 92.96 | 10.24 | 101 | 88948 | 15688 | 79639651 |
| Hand deformity | 92.34 | 10.24 | 6 | 89043 | 103913 | 79551426 |
| Paradoxical drug reaction | 91.85 | 10.24 | 71 | 88978 | 7114 | 79648225 |
| Body tinea | 89.52 | 10.24 | 43 | 89006 | 1811 | 79653528 |
| Cardiac arrest | 89.35 | 10.24 | 405 | 88644 | 171691 | 79483648 |
| Fluid retention | 88.41 | 10.24 | 222 | 88827 | 69587 | 79585752 |
| Arthropathy | 87.78 | 10.24 | 44 | 89005 | 177067 | 79478272 |
| Blood pressure inadequately controlled | 87.72 | 10.24 | 65 | 88984 | 6112 | 79649227 |
| Rash erythematous | 87.54 | 10.24 | 197 | 88852 | 57572 | 79597767 |
| Sedation | 85.47 | 10.24 | 183 | 88866 | 51712 | 79603627 |
| Hypertensive emergency | 83.75 | 10.24 | 47 | 89002 | 2738 | 79652601 |
| Neovascularisation | 82.54 | 10.24 | 36 | 89013 | 1209 | 79654130 |
| Oppositional defiant disorder | 82.35 | 10.24 | 28 | 89021 | 469 | 79654870 |
| Pemphigus | 82.21 | 10.24 | 8 | 89041 | 99574 | 79555765 |
| Victim of child abuse | 81.40 | 10.24 | 33 | 89016 | 920 | 79654419 |
| Malignant catatonia | 80.21 | 10.24 | 27 | 89022 | 438 | 79654901 |
| Respiratory arrest | 77.08 | 10.24 | 187 | 88862 | 57363 | 79597976 |
| Alopecia | 75.74 | 10.24 | 88 | 88961 | 231267 | 79424072 |
| Neutropenia | 75.69 | 10.24 | 128 | 88921 | 287582 | 79367757 |
| Agitation | 73.66 | 10.24 | 262 | 88787 | 99453 | 79555886 |
| Anti-cyclic citrullinated peptide antibody positive | 73.28 | 10.24 | 5 | 89044 | 83138 | 79572201 |
| Nephrogenic systemic fibrosis | 72.55 | 10.24 | 58 | 88991 | 6102 | 79649237 |
| Arthralgia | 70.95 | 10.24 | 363 | 88686 | 571440 | 79083899 |
| Joint swelling | 70.03 | 10.24 | 135 | 88914 | 288511 | 79366828 |
| Febrile neutropenia | 69.21 | 10.24 | 94 | 88955 | 230905 | 79424434 |
| Infection susceptibility increased | 68.76 | 10.24 | 46 | 89003 | 3675 | 79651664 |
| Pericarditis | 68.70 | 10.24 | 16 | 89033 | 104220 | 79551119 |
| Lethargy | 68.30 | 10.24 | 223 | 88826 | 81069 | 79574270 |
| Suspected suicide | 68.19 | 10.24 | 71 | 88978 | 10505 | 79644834 |
| Hypertensive encephalopathy | 67.08 | 10.24 | 29 | 89020 | 953 | 79654386 |
| Upper respiratory tract infection | 66.87 | 10.24 | 239 | 88810 | 90929 | 79564410 |
| Glossodynia | 65.89 | 10.24 | 17 | 89032 | 103320 | 79552019 |
| Blood pressure increased | 64.78 | 10.24 | 431 | 88618 | 210929 | 79444410 |
| Interstitial lung disease | 63.73 | 10.24 | 23 | 89026 | 112577 | 79542762 |
| Malignant neoplasm progression | 62.69 | 10.24 | 37 | 89012 | 135953 | 79519386 |
| Inhibitory drug interaction | 61.32 | 10.24 | 46 | 89003 | 4407 | 79650932 |
| Myocardial infarction | 61.03 | 10.24 | 383 | 88666 | 183746 | 79471593 |
| Decreased eye contact | 60.58 | 10.24 | 26 | 89023 | 839 | 79654500 |
| Systemic lupus erythematosus | 60.16 | 10.24 | 30 | 89019 | 121119 | 79534220 |
| Choreoathetosis | 59.81 | 10.24 | 31 | 89018 | 1539 | 79653800 |
| Unresponsive to stimuli | 58.07 | 10.24 | 165 | 88884 | 55623 | 79599716 |
| Epidural lipomatosis | 57.84 | 10.24 | 28 | 89021 | 1200 | 79654139 |
| Poor quality sleep | 57.14 | 10.24 | 96 | 88953 | 22626 | 79632713 |
| Drug intolerance | 55.37 | 10.24 | 134 | 88915 | 263985 | 79391354 |
| Homicidal ideation | 55.07 | 10.24 | 39 | 89010 | 3418 | 79651921 |
| Accidental overdose | 54.49 | 10.24 | 130 | 88919 | 39451 | 79615888 |
| Helicobacter infection | 54.00 | 10.24 | 7 | 89042 | 69697 | 79585642 |
| Application site pruritus | 51.67 | 10.24 | 39 | 89010 | 3771 | 79651568 |
| Lower respiratory tract infection | 50.52 | 10.24 | 42 | 89007 | 129178 | 79526161 |
| Glucose tolerance impaired | 49.85 | 10.24 | 53 | 88996 | 8031 | 79647308 |
| Infusion related reaction | 49.69 | 10.24 | 115 | 88934 | 230122 | 79425217 |
| Wound | 48.93 | 10.24 | 35 | 89014 | 116144 | 79539195 |
| Cardio-respiratory arrest | 48.75 | 10.24 | 245 | 88804 | 108265 | 79547074 |
| Rash | 48.49 | 10.24 | 413 | 88636 | 577945 | 79077394 |
| Diarrhoea | 47.23 | 10.24 | 696 | 88353 | 879793 | 78775546 |
| Drug ineffective for unapproved indication | 46.17 | 10.24 | 144 | 88905 | 51094 | 79604245 |
| Application site irritation | 45.94 | 10.24 | 27 | 89022 | 1717 | 79653622 |
| Application site rash | 45.88 | 10.24 | 29 | 89020 | 2103 | 79653236 |
| Therapeutic product effect decreased | 45.79 | 10.24 | 70 | 88979 | 163793 | 79491546 |
| Infection | 45.79 | 10.24 | 129 | 88920 | 241583 | 79413756 |
| Intentional product misuse | 45.70 | 10.24 | 219 | 88830 | 94946 | 79560393 |
| Maternal exposure during pregnancy | 45.68 | 10.24 | 51 | 88998 | 136487 | 79518852 |
| Trismus | 45.11 | 10.24 | 42 | 89007 | 5425 | 79649914 |
| Medical device site pain | 45.04 | 10.24 | 16 | 89033 | 307 | 79655032 |
| Swelling | 44.58 | 10.24 | 111 | 88938 | 216600 | 79438739 |
| C-reactive protein increased | 44.48 | 10.24 | 47 | 89002 | 128980 | 79526359 |
| Anxiety | 44.24 | 10.24 | 448 | 88601 | 248064 | 79407275 |
| Product tampering | 44.20 | 10.24 | 17 | 89032 | 411 | 79654928 |
| Rheumatoid factor positive | 44.05 | 10.24 | 7 | 89042 | 59832 | 79595507 |
| Duodenal ulcer perforation | 43.95 | 10.24 | 10 | 89039 | 66201 | 79589138 |
| Nasopharyngitis | 42.07 | 10.24 | 144 | 88905 | 253737 | 79401602 |
| Hepatic function abnormal | 41.25 | 10.24 | 15 | 89034 | 73092 | 79582247 |
| Pyrexia | 41.20 | 10.24 | 523 | 88526 | 678186 | 78977153 |
| Irritability | 41.18 | 10.24 | 120 | 88929 | 41024 | 79614315 |
| Peritonitis bacterial | 40.99 | 10.24 | 52 | 88997 | 9515 | 79645824 |
| Neuroleptic malignant syndrome | 40.65 | 10.24 | 93 | 88956 | 27466 | 79627873 |
| Acute motor-sensory axonal neuropathy | 40.62 | 10.24 | 16 | 89033 | 413 | 79654926 |
| Suicidal ideation | 40.58 | 10.24 | 181 | 88868 | 76159 | 79579180 |
| Constipation | 39.76 | 10.24 | 487 | 88562 | 282563 | 79372776 |
| Folliculitis | 39.61 | 10.24 | 7 | 89042 | 55373 | 79599966 |
| Implant site extravasation | 39.56 | 10.24 | 19 | 89030 | 800 | 79654539 |
| Blood prolactin increased | 39.40 | 10.24 | 34 | 89015 | 3977 | 79651362 |
| Toxic epidermal necrolysis | 38.98 | 10.24 | 124 | 88925 | 44457 | 79610882 |
| Adulterated product | 38.87 | 10.24 | 14 | 89035 | 280 | 79655059 |
| Condition aggravated | 38.84 | 10.24 | 365 | 88684 | 500759 | 79154580 |
| Obesity | 38.63 | 10.24 | 106 | 88943 | 35019 | 79620320 |
| Apnoea | 38.56 | 10.24 | 56 | 88993 | 11648 | 79643691 |
| Psoriatic arthropathy | 37.70 | 10.24 | 20 | 89029 | 77979 | 79577360 |
| Product substitution issue | 37.54 | 10.24 | 75 | 88974 | 20181 | 79635158 |
| Neutrophil count decreased | 37.39 | 10.24 | 30 | 89019 | 93929 | 79561410 |
| Crying | 36.49 | 10.24 | 80 | 88969 | 22963 | 79632376 |
| Impaired healing | 36.14 | 10.24 | 27 | 89022 | 87628 | 79567711 |
| Psychomotor hyperactivity | 35.66 | 10.24 | 66 | 88983 | 16783 | 79638556 |
| Intestinal angioedema | 35.27 | 10.24 | 18 | 89031 | 865 | 79654474 |
| Medication error | 35.18 | 10.24 | 161 | 88888 | 68481 | 79586858 |
| Malignant hypertension | 34.75 | 10.24 | 22 | 89027 | 1600 | 79653739 |
| Dystonia | 34.69 | 10.24 | 75 | 88974 | 21324 | 79634015 |
| Left ventricular hypertrophy | 34.65 | 10.24 | 52 | 88997 | 11139 | 79644200 |
| Coronary artery disease | 34.62 | 10.24 | 155 | 88894 | 65319 | 79590020 |
| Application site erythema | 34.19 | 10.24 | 35 | 89014 | 5075 | 79650264 |
| Hyperaesthesia | 33.93 | 10.24 | 54 | 88995 | 12168 | 79643171 |
| Catatonia | 33.48 | 10.24 | 45 | 89004 | 8711 | 79646628 |
| Anti-neutrophil cytoplasmic antibody positive vasculitis | 33.41 | 10.24 | 30 | 89019 | 3699 | 79651640 |
| Irritable bowel syndrome | 33.09 | 10.24 | 14 | 89035 | 62227 | 79593112 |
| Overweight | 32.55 | 10.24 | 31 | 89018 | 4119 | 79651220 |
| White blood cell count decreased | 32.41 | 10.24 | 105 | 88944 | 188183 | 79467156 |
| Gastrointestinal tract mucosal pigmentation | 32.34 | 10.24 | 18 | 89031 | 1032 | 79654307 |
| Sleep disorder due to general medical condition, insomnia type | 32.27 | 10.24 | 5 | 89044 | 43551 | 79611788 |
| Brain injury | 32.13 | 10.24 | 51 | 88998 | 11466 | 79643873 |
| Emotional distress | 32.09 | 10.24 | 108 | 88941 | 39861 | 79615478 |
| Hyperlipidaemia | 32.00 | 10.24 | 82 | 88967 | 26011 | 79629328 |
| Intentional product use issue | 31.99 | 10.24 | 77 | 88972 | 152035 | 79503304 |
| Claustrophobia | 31.73 | 10.24 | 19 | 89030 | 1251 | 79654088 |
| Sinusitis | 31.62 | 10.24 | 112 | 88937 | 195389 | 79459950 |
| Liver disorder | 31.57 | 10.24 | 21 | 89028 | 72396 | 79582943 |
| Arthritis | 31.21 | 10.24 | 50 | 88999 | 114830 | 79540509 |
| Discomfort | 31.09 | 10.24 | 58 | 88991 | 125559 | 79529780 |
| Loss of consciousness | 30.46 | 10.24 | 304 | 88745 | 167639 | 79487700 |
| Child abuse | 30.39 | 10.24 | 13 | 89036 | 416 | 79654923 |
| Bruxism | 29.56 | 10.24 | 29 | 89020 | 3997 | 79651342 |
| Kidney transplant rejection | 29.45 | 10.24 | 46 | 89003 | 10200 | 79645139 |
| Drug screen positive | 29.27 | 10.24 | 35 | 89014 | 6028 | 79649311 |
| Abdominal discomfort | 28.88 | 10.24 | 163 | 88886 | 250564 | 79404775 |
| Impaired quality of life | 28.76 | 10.24 | 55 | 88994 | 14331 | 79641008 |
| Chronic kidney disease | 28.74 | 10.24 | 148 | 88901 | 66006 | 79589333 |
| Acute myocardial infarction | 28.53 | 10.24 | 165 | 88884 | 76871 | 79578468 |
| Tardive dyskinesia | 28.38 | 10.24 | 46 | 89003 | 10525 | 79644814 |
| Disease progression | 28.25 | 10.24 | 108 | 88941 | 184254 | 79471085 |
| Skin hypertrophy | 28.10 | 10.24 | 31 | 89018 | 4897 | 79650442 |
| Osteonecrosis of jaw | 27.76 | 10.24 | 7 | 89042 | 43219 | 79612120 |
| Pneumonia | 27.50 | 10.24 | 546 | 88503 | 659700 | 78995639 |
| Hypoventilation | 27.43 | 10.24 | 37 | 89012 | 7187 | 79648152 |
| Product compounding quality issue | 27.31 | 10.24 | 7 | 89042 | 40 | 79655299 |
| Depressed level of consciousness | 27.14 | 10.24 | 193 | 88856 | 96459 | 79558880 |
| Aplastic anaemia | 27.05 | 10.24 | 61 | 88988 | 17844 | 79637495 |
| Skin induration | 26.73 | 10.24 | 29 | 89020 | 4496 | 79650843 |
| Tic | 26.71 | 10.24 | 24 | 89025 | 2962 | 79652377 |
| Bone density decreased | 26.65 | 10.24 | 51 | 88998 | 13296 | 79642043 |
| Posterior reversible encephalopathy syndrome | 26.63 | 10.24 | 77 | 88972 | 26204 | 79629135 |
| Anhedonia | 26.22 | 10.24 | 54 | 88995 | 14844 | 79640495 |
| Nodal rhythm | 25.71 | 10.24 | 24 | 89025 | 3111 | 79652228 |
| Inflammation | 25.28 | 10.24 | 41 | 89008 | 93712 | 79561627 |
| Medical device site discharge | 25.27 | 10.24 | 7 | 89042 | 56 | 79655283 |
| Asthma | 25.20 | 10.24 | 246 | 88803 | 134849 | 79520490 |
| Dyskinesia | 25.19 | 10.24 | 108 | 88941 | 44665 | 79610674 |
| Epilepsy with myoclonic-atonic seizures | 25.12 | 10.24 | 8 | 89041 | 108 | 79655231 |
| Back pain | 25.08 | 10.24 | 478 | 88571 | 303702 | 79351637 |
| Anal inflammation | 24.81 | 10.24 | 17 | 89032 | 1413 | 79653926 |
| Product adhesion issue | 24.71 | 10.24 | 22 | 89027 | 2682 | 79652657 |
| Autonomic nervous system imbalance | 24.47 | 10.24 | 28 | 89021 | 4602 | 79650737 |
| Renin decreased | 24.47 | 10.24 | 8 | 89041 | 118 | 79655221 |
| Akathisia | 24.46 | 10.24 | 49 | 89000 | 13210 | 79642129 |
| Product prescribing error | 24.38 | 10.24 | 107 | 88942 | 44706 | 79610633 |
| Anger | 24.30 | 10.24 | 57 | 88992 | 17105 | 79638234 |
| Pulse abnormal | 24.15 | 10.24 | 24 | 89025 | 3360 | 79651979 |
| Mood swings | 23.89 | 10.24 | 62 | 88987 | 19818 | 79635521 |
| Juvenile idiopathic arthritis | 23.83 | 10.24 | 28 | 89021 | 4735 | 79650604 |
| Thrombocytopenia | 23.73 | 10.24 | 186 | 88863 | 265073 | 79390266 |
| Extrapyramidal disorder | 23.52 | 10.24 | 67 | 88982 | 22612 | 79632727 |
| Basal ganglion degeneration | 23.50 | 10.24 | 11 | 89038 | 437 | 79654902 |
| Pneumocystis jirovecii pneumonia | 23.49 | 10.24 | 4 | 89045 | 32504 | 79622835 |
| Device infusion issue | 23.42 | 10.24 | 20 | 89029 | 2306 | 79653033 |
| Hypothermia | 23.40 | 10.24 | 67 | 88982 | 22679 | 79632660 |
| Intestinal pseudo-obstruction | 23.39 | 10.24 | 21 | 89028 | 2588 | 79652751 |
| Blood aldosterone increased | 23.34 | 10.24 | 9 | 89040 | 219 | 79655120 |
| Pulmonary fibrosis | 23.32 | 10.24 | 10 | 89039 | 44102 | 79611237 |
| Seizure | 23.16 | 10.24 | 317 | 88732 | 188517 | 79466822 |
| Leukopenia | 22.93 | 10.24 | 61 | 88988 | 116452 | 79538887 |
| Musculoskeletal stiffness | 22.83 | 10.24 | 109 | 88940 | 174899 | 79480440 |
| Primary hyperaldosteronism | 22.79 | 10.24 | 8 | 89041 | 148 | 79655191 |
| Anuria | 22.79 | 10.24 | 63 | 88986 | 20900 | 79634439 |
| Attention deficit hyperactivity disorder | 22.75 | 10.24 | 23 | 89026 | 3286 | 79652053 |
| COVID-19 | 22.49 | 10.24 | 95 | 88954 | 157579 | 79497760 |
| Pancytopenia | 22.35 | 10.24 | 102 | 88947 | 165643 | 79489696 |
| Hepatitis | 21.91 | 10.24 | 18 | 89031 | 55709 | 79599630 |
| Anaesthesia | 21.80 | 10.24 | 11 | 89038 | 516 | 79654823 |
| Oromandibular dystonia | 21.80 | 10.24 | 14 | 89035 | 1044 | 79654295 |
| Application site discolouration | 21.78 | 10.24 | 13 | 89036 | 851 | 79654488 |
| Tissue infiltration | 21.70 | 10.24 | 12 | 89037 | 679 | 79654660 |
| Lymphopenia | 21.55 | 10.24 | 4 | 89045 | 30553 | 79624786 |
| Accelerated hypertension | 21.53 | 10.24 | 12 | 89037 | 690 | 79654649 |
| Loss of personal independence in daily activities | 21.50 | 10.24 | 52 | 88997 | 102528 | 79552811 |
| Abnormal behaviour | 21.38 | 10.24 | 89 | 88960 | 36332 | 79619007 |
| Neoplasm progression | 21.20 | 10.24 | 16 | 89033 | 51666 | 79603673 |
| Platelet count decreased | 21.11 | 10.24 | 129 | 88920 | 194535 | 79460804 |
| General physical health deterioration | 21.05 | 10.24 | 201 | 88848 | 275037 | 79380302 |
| Rash maculo-papular | 20.97 | 10.24 | 19 | 89030 | 56059 | 79599280 |
| Implant site infection | 20.78 | 10.24 | 17 | 89032 | 1848 | 79653491 |
| Tremor | 20.64 | 10.24 | 285 | 88764 | 169798 | 79485541 |
| Dialysis | 20.58 | 10.24 | 56 | 88993 | 18406 | 79636933 |
| Retrograde amnesia | 20.37 | 10.24 | 11 | 89038 | 594 | 79654745 |
| Neutropenic sepsis | 20.30 | 10.24 | 3 | 89046 | 27061 | 79628278 |
| Prostate cancer | 20.22 | 10.24 | 6 | 89043 | 33262 | 79622077 |
| Cancer pain | 20.12 | 10.24 | 27 | 89022 | 5218 | 79650121 |
| Somatic symptom disorder | 19.99 | 10.24 | 19 | 89030 | 2518 | 79652821 |
| Productive cough | 19.95 | 10.24 | 43 | 89006 | 88288 | 79567051 |
| Fibrosis | 19.87 | 10.24 | 27 | 89022 | 5282 | 79650057 |
| Acute myeloid leukaemia | 19.84 | 10.24 | 5 | 89044 | 30880 | 79624459 |
| Gastrointestinal disorder | 19.76 | 10.24 | 70 | 88979 | 122135 | 79533204 |
| Alanine aminotransferase increased | 19.64 | 10.24 | 104 | 88945 | 162466 | 79492873 |
| Haematochezia | 19.52 | 10.24 | 43 | 89006 | 87602 | 79567737 |
| Peripheral swelling | 19.32 | 10.24 | 200 | 88849 | 269417 | 79385922 |
| Device failure | 19.25 | 10.24 | 29 | 89020 | 6232 | 79649107 |
| Hyperreflexia | 19.21 | 10.24 | 34 | 89015 | 8351 | 79646988 |
| Insomnia | 19.09 | 10.24 | 382 | 88667 | 244788 | 79410551 |
| Foetal death | 18.93 | 10.24 | 33 | 89016 | 8011 | 79647328 |
| Urinary incontinence | 18.81 | 10.24 | 93 | 88956 | 40816 | 79614523 |
| Reaction to excipient | 18.79 | 10.24 | 15 | 89034 | 1574 | 79653765 |
| Atrioventricular block second degree | 18.53 | 10.24 | 31 | 89018 | 7281 | 79648058 |
| SARS-CoV-2 test negative | 18.52 | 10.24 | 14 | 89035 | 1357 | 79653982 |
| Norepinephrine increased | 18.51 | 10.24 | 6 | 89043 | 86 | 79655253 |
| Hypotonia | 18.50 | 10.24 | 43 | 89006 | 12827 | 79642512 |
| Drug withdrawal headache | 18.44 | 10.24 | 6 | 89043 | 87 | 79655252 |
| Skin disorder | 18.43 | 10.24 | 81 | 88968 | 33862 | 79621477 |
| Autism spectrum disorder | 18.36 | 10.24 | 13 | 89036 | 1139 | 79654200 |
| Osteoporosis | 18.32 | 10.24 | 20 | 89029 | 54092 | 79601247 |
| Atrioventricular block first degree | 18.25 | 10.24 | 42 | 89007 | 12449 | 79642890 |
| Colitis ulcerative | 18.17 | 10.24 | 8 | 89041 | 34734 | 79620605 |
| Respiratory moniliasis | 18.06 | 10.24 | 8 | 89041 | 279 | 79655060 |
| Device power source issue | 18.02 | 10.24 | 12 | 89037 | 951 | 79654388 |
| Sympathomimetic effect | 17.79 | 10.24 | 6 | 89043 | 98 | 79655241 |
| Pernicious anaemia | 17.76 | 10.24 | 10 | 89039 | 586 | 79654753 |
| Cytomegalovirus infection | 17.75 | 10.24 | 13 | 89036 | 42631 | 79612708 |
| Osteoarthritis | 17.72 | 10.24 | 45 | 89004 | 87264 | 79568075 |
| Injection site erythema | 17.72 | 10.24 | 38 | 89011 | 78159 | 79577180 |
| Purpura | 17.70 | 10.24 | 55 | 88994 | 19472 | 79635867 |
| Vascular stenosis | 17.61 | 10.24 | 10 | 89039 | 596 | 79654743 |
| Muscle contracture | 17.59 | 10.24 | 17 | 89032 | 2300 | 79653039 |
| Drug eruption | 17.51 | 10.24 | 14 | 89035 | 43921 | 79611418 |
| Product administered to patient of inappropriate age | 17.47 | 10.24 | 26 | 89023 | 5527 | 79649812 |
| Basal cell carcinoma | 17.45 | 10.24 | 10 | 89039 | 37365 | 79617974 |
| Bone marrow failure | 17.18 | 10.24 | 19 | 89030 | 51088 | 79604251 |
| Coma scale abnormal | 17.13 | 10.24 | 33 | 89016 | 8645 | 79646694 |
| Mood altered | 16.86 | 10.24 | 51 | 88998 | 17796 | 79637543 |
| Abortion spontaneous | 16.74 | 10.24 | 6 | 89043 | 29501 | 79625838 |
| Infusion site mass | 16.66 | 10.24 | 14 | 89035 | 1579 | 79653760 |
| Affect lability | 16.61 | 10.24 | 38 | 89011 | 11221 | 79644118 |
| Incision site pain | 16.48 | 10.24 | 18 | 89031 | 2812 | 79652527 |
| Injection site abscess | 16.31 | 10.24 | 14 | 89035 | 1626 | 79653713 |
| Cytokine release syndrome | 16.29 | 10.24 | 10 | 89039 | 35988 | 79619351 |
| Uterine enlargement | 16.24 | 10.24 | 11 | 89038 | 897 | 79654442 |
| Change in seizure presentation | 16.22 | 10.24 | 9 | 89040 | 513 | 79654826 |
| Corneal reflex decreased | 16.14 | 10.24 | 8 | 89041 | 361 | 79654978 |
| Rash pruritic | 16.07 | 10.24 | 35 | 89014 | 71594 | 79583745 |
| Melaena | 16.07 | 10.24 | 27 | 89022 | 60863 | 79594476 |
| Agranulocytosis | 15.97 | 10.24 | 16 | 89033 | 45014 | 79610325 |
| Pulse absent | 15.91 | 10.24 | 35 | 89014 | 10068 | 79645271 |
| Rheumatic fever | 15.84 | 10.24 | 6 | 89043 | 28519 | 79626820 |
| Serotonin syndrome | 15.74 | 10.24 | 95 | 88954 | 44932 | 79610407 |
| Respiratory rate decreased | 15.72 | 10.24 | 24 | 89025 | 5219 | 79650120 |
| Pain in jaw | 15.69 | 10.24 | 17 | 89032 | 46134 | 79609205 |
| Mast cell degranulation present | 15.66 | 10.24 | 5 | 89044 | 68 | 79655271 |
| Malaise | 15.61 | 10.24 | 422 | 88627 | 489447 | 79165892 |
| Hyperthyroidism | 15.47 | 10.24 | 3 | 89046 | 22206 | 79633133 |
| Medical device site infection | 15.46 | 10.24 | 9 | 89040 | 562 | 79654777 |
| Application site papules | 15.34 | 10.24 | 5 | 89044 | 73 | 79655266 |
| Hyperkinesia | 15.27 | 10.24 | 17 | 89032 | 2712 | 79652627 |
| Prescribed overdose | 15.25 | 10.24 | 83 | 88966 | 37800 | 79617539 |
| Chest discomfort | 15.21 | 10.24 | 91 | 88958 | 137953 | 79517386 |
| Labelled drug-drug interaction medication error | 15.05 | 10.24 | 6 | 89043 | 27644 | 79627695 |
| Speech disorder | 14.87 | 10.24 | 108 | 88941 | 54337 | 79601002 |
| Drooling | 14.82 | 10.24 | 25 | 89024 | 5909 | 79649430 |
| Saccadic eye movement | 14.78 | 10.24 | 6 | 89043 | 168 | 79655171 |
| Drug tolerance | 14.75 | 10.24 | 31 | 89018 | 8644 | 79646695 |
| Renal injury | 14.72 | 10.24 | 47 | 89002 | 16880 | 79638459 |
| Implant site discharge | 14.68 | 10.24 | 6 | 89043 | 171 | 79655168 |
| Gamma-glutamyltransferase increased | 14.66 | 10.24 | 24 | 89025 | 54656 | 79600683 |
| Iliac artery stenosis | 14.51 | 10.24 | 6 | 89043 | 176 | 79655163 |
| Pulmonary renal syndrome | 14.51 | 10.24 | 9 | 89040 | 631 | 79654708 |
| Blood potassium increased | 14.50 | 10.24 | 68 | 88981 | 29207 | 79626132 |
| Neurological symptom | 14.49 | 10.24 | 31 | 89018 | 8752 | 79646587 |
| Renal transplant | 14.48 | 10.24 | 16 | 89033 | 2531 | 79652808 |
| Brief psychotic disorder with marked stressors | 14.42 | 10.24 | 7 | 89042 | 302 | 79655037 |
| Cardiac hypertrophy | 14.38 | 10.24 | 13 | 89036 | 1617 | 79653722 |
| Mobility decreased | 14.29 | 10.24 | 79 | 88970 | 122096 | 79533243 |
| Pneumonitis | 14.27 | 10.24 | 29 | 89020 | 60831 | 79594508 |
| Glomerulonephritis rapidly progressive | 14.26 | 10.24 | 13 | 89036 | 1635 | 79653704 |
| Focal segmental glomerulosclerosis | 14.15 | 10.24 | 18 | 89031 | 3303 | 79652036 |
| Product preparation issue | 13.95 | 10.24 | 12 | 89037 | 1398 | 79653941 |
| Impaired work ability | 13.92 | 10.24 | 51 | 88998 | 19630 | 79635709 |
| Joint injury | 13.77 | 10.24 | 9 | 89040 | 31326 | 79624013 |
| Hyponatraemia | 13.54 | 10.24 | 130 | 88919 | 177718 | 79477621 |
| Hip arthroplasty | 13.51 | 10.24 | 12 | 89037 | 35744 | 79619595 |
| Renal artery stenosis | 13.47 | 10.24 | 18 | 89031 | 3464 | 79651875 |
| Hypoxic-ischaemic encephalopathy | 13.36 | 10.24 | 28 | 89021 | 7792 | 79647547 |
| Pulmonary oedema | 13.31 | 10.24 | 154 | 88895 | 88100 | 79567239 |
| Pruritus | 13.08 | 10.24 | 338 | 88711 | 394310 | 79261029 |
| Hepatic cytolysis | 13.06 | 10.24 | 7 | 89042 | 27144 | 79628195 |
| Hypertensive urgency | 13.04 | 10.24 | 8 | 89041 | 550 | 79654789 |
| Delirium | 12.91 | 10.24 | 148 | 88901 | 84479 | 79570860 |
| Multiple sclerosis relapse | 12.87 | 10.24 | 20 | 89029 | 46513 | 79608826 |
| Hypertrichosis | 12.86 | 10.24 | 11 | 89038 | 1271 | 79654068 |
| Bladder cancer | 12.86 | 10.24 | 3 | 89046 | 19523 | 79635816 |
| Human herpesvirus 6 infection reactivation | 12.82 | 10.24 | 8 | 89041 | 567 | 79654772 |
| Product prescribing issue | 12.81 | 10.24 | 19 | 89030 | 4026 | 79651313 |
| Product quality issue | 12.76 | 10.24 | 73 | 88976 | 33867 | 79621472 |
| Mydriasis | 12.71 | 10.24 | 46 | 89003 | 17597 | 79637742 |
| Drug detoxification | 12.66 | 10.24 | 7 | 89042 | 396 | 79654943 |
| Stress cardiomyopathy | 12.58 | 10.24 | 34 | 89015 | 11132 | 79644207 |
| End stage renal disease | 12.57 | 10.24 | 36 | 89013 | 12184 | 79643155 |
| Knee arthroplasty | 12.53 | 10.24 | 18 | 89031 | 43230 | 79612109 |
| Autoimmune enteropathy | 12.49 | 10.24 | 4 | 89045 | 55 | 79655284 |
| Contraindicated product administered | 12.49 | 10.24 | 114 | 88935 | 157424 | 79497915 |
| Educational problem | 12.49 | 10.24 | 7 | 89042 | 407 | 79654932 |
| Normochromic normocytic anaemia | 12.43 | 10.24 | 27 | 89022 | 7700 | 79647639 |
| Accidental poisoning | 12.29 | 10.24 | 12 | 89037 | 1645 | 79653694 |
| Mucosal erosion | 12.22 | 10.24 | 14 | 89035 | 2304 | 79653035 |
| Skin tightness | 12.15 | 10.24 | 22 | 89027 | 5500 | 79649839 |
| Peritoneal dialysis complication | 12.05 | 10.24 | 14 | 89035 | 2340 | 79652999 |
| Exposure during pregnancy | 12.04 | 10.24 | 65 | 88984 | 101067 | 79554272 |
| Device expulsion | 11.96 | 10.24 | 7 | 89042 | 25854 | 79629485 |
| Eczema | 11.82 | 10.24 | 17 | 89032 | 40801 | 79614538 |
| Hypersomnia | 11.71 | 10.24 | 54 | 88995 | 23032 | 79632307 |
| Tendonitis | 11.68 | 10.24 | 6 | 89043 | 23824 | 79631515 |
| Gun shot wound | 11.66 | 10.24 | 10 | 89039 | 1160 | 79654179 |
| Myelodysplastic syndrome | 11.65 | 10.24 | 10 | 89039 | 30291 | 79625048 |
| Myalgia | 11.60 | 10.24 | 142 | 88907 | 185499 | 79469840 |
| Pain | 11.58 | 10.24 | 924 | 88125 | 702878 | 78952461 |
| Sinus arrhythmia | 11.56 | 10.24 | 13 | 89036 | 2097 | 79653242 |
| Page kidney | 11.55 | 10.24 | 4 | 89045 | 71 | 79655268 |
| Grip strength decreased | 11.49 | 10.24 | 5 | 89044 | 21864 | 79633475 |
| Vision blurred | 11.47 | 10.24 | 174 | 88875 | 105724 | 79549615 |
| Adrenal insufficiency | 11.45 | 10.24 | 9 | 89040 | 28478 | 79626861 |
| Right ventricular failure | 11.39 | 10.24 | 6 | 89043 | 23491 | 79631848 |
| Blood bilirubin increased | 11.34 | 10.24 | 37 | 89012 | 66195 | 79589144 |
| Femur fracture | 11.29 | 10.24 | 16 | 89033 | 38636 | 79616703 |
| Joint contracture | 11.26 | 10.24 | 14 | 89035 | 2510 | 79652829 |
| Bone erosion | 11.25 | 10.24 | 3 | 89046 | 17844 | 79637495 |
| Skin fibrosis | 11.23 | 10.24 | 11 | 89038 | 1513 | 79653826 |
| Therapeutic drug monitoring analysis incorrectly performed | 11.23 | 10.24 | 8 | 89041 | 708 | 79654631 |
| Encephalomalacia | 11.15 | 10.24 | 10 | 89039 | 1231 | 79654108 |
| Ill-defined disorder | 11.14 | 10.24 | 37 | 89012 | 65838 | 79589501 |
| Aspartate aminotransferase increased | 11.13 | 10.24 | 100 | 88949 | 138541 | 79516798 |
| Medical device site erythema | 11.11 | 10.24 | 4 | 89045 | 80 | 79655259 |
| Medical device site swelling | 11.01 | 10.24 | 4 | 89045 | 82 | 79655257 |
| Gastric hypomotility | 10.96 | 10.24 | 5 | 89044 | 187 | 79655152 |
| Swollen joint count increased | 10.90 | 10.24 | 6 | 89043 | 22921 | 79632418 |
| Drug resistance | 10.88 | 10.24 | 19 | 89030 | 42194 | 79613145 |
| Renal transplant failure | 10.88 | 10.24 | 12 | 89037 | 1895 | 79653444 |
| Device programming error | 10.86 | 10.24 | 5 | 89044 | 191 | 79655148 |
| Peau d'orange | 10.86 | 10.24 | 6 | 89043 | 339 | 79655000 |
| Hyperbilirubinaemia | 10.83 | 10.24 | 7 | 89042 | 24511 | 79630828 |
| Psychogenic seizure | 10.76 | 10.24 | 12 | 89037 | 1919 | 79653420 |
| Nervousness | 10.74 | 10.24 | 69 | 88980 | 33346 | 79621993 |
| Pleural effusion | 10.71 | 10.24 | 107 | 88942 | 145155 | 79510184 |
| Labile hypertension | 10.66 | 10.24 | 7 | 89042 | 542 | 79654797 |
| Respiratory failure | 10.65 | 10.24 | 271 | 88778 | 180640 | 79474699 |
| Drug dependence, antepartum | 10.62 | 10.24 | 3 | 89046 | 26 | 79655313 |
| Gastric ileus | 10.52 | 10.24 | 3 | 89046 | 27 | 79655312 |
| Foot deformity | 10.47 | 10.24 | 7 | 89042 | 24067 | 79631272 |
| Toxic skin eruption | 10.36 | 10.24 | 6 | 89043 | 22287 | 79633052 |
| Electrocardiogram QRS complex prolonged | 10.27 | 10.24 | 31 | 89018 | 10802 | 79644537 |
| Left atrial dilatation | 10.26 | 10.24 | 15 | 89034 | 3138 | 79652201 |
| Blood creatinine increased | 10.26 | 10.24 | 236 | 88813 | 154821 | 79500518 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C02AC01 | CARDIOVASCULAR SYSTEM ANTIHYPERTENSIVES ANTIADRENERGIC AGENTS, CENTRALLY ACTING Imidazoline receptor agonists |
| ATC | C02LC01 | CARDIOVASCULAR SYSTEM ANTIHYPERTENSIVES ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION Imidazoline receptor agonists in combination with diuretics |
| ATC | C02LC51 | CARDIOVASCULAR SYSTEM ANTIHYPERTENSIVES ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION Imidazoline receptor agonists in combination with diuretics |
| ATC | N02CX02 | NERVOUS SYSTEM ANALGESICS ANTIMIGRAINE PREPARATIONS Other antimigraine preparations |
| ATC | S01EA04 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Sympathomimetics in glaucoma therapy |
| FDA MoA | N0000009918 | Adrenergic alpha2-Agonists |
| FDA EPC | N0000175554 | Central alpha-2 Adrenergic Agonist |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D000322 | Adrenergic Agonists |
| MeSH PA | D058647 | Adrenergic alpha-2 Receptor Agonists |
| MeSH PA | D000316 | Adrenergic alpha-Agonists |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
| MeSH PA | D013565 | Sympatholytics |
| CHEBI has role | CHEBI:35569 | alpha-adrenergic agonists |
| CHEBI has role | CHEBI:35674 | antihypertensive drugs |
| CHEBI has role | CHEBI:66991 | sympatholytic drug |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
| Severe pain | indication | 76948002 | |
| Open-angle glaucoma | indication | 84494001 | DOID:1067 |
| Attention deficit hyperactivity disorder | indication | 406506008 | |
| Increased Intraocular Pressure after Ocular Procedure | indication | ||
| Ocular hypertension | off-label use | 4210003 | DOID:9282 |
| Gilles de la Tourette's syndrome | off-label use | 5158005 | DOID:11119 |
| Pain | off-label use | 22253000 | |
| Diarrhea | off-label use | 62315008 | |
| Opioid withdrawal | off-label use | 87132004 | |
| Menopausal flushing | off-label use | 198436008 | |
| Smoking cessation assistance | off-label use | 384742004 | |
| Nicotine Withdrawal Symptoms | off-label use | ||
| Anuria | contraindication | 2472002 | DOID:2983 |
| Hypercholesterolemia | contraindication | 13644009 | |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Depressive disorder | contraindication | 35489007 | |
| Hyperuricemia | contraindication | 35885006 | DOID:1920 |
| Hypokalemia | contraindication | 43339004 | |
| Diabetes mellitus type 2 | contraindication | 44054006 | DOID:9352 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Low blood pressure | contraindication | 45007003 | |
| Tear film insufficiency | contraindication | 46152009 | |
| End stage renal disease | contraindication | 46177005 | DOID:784 |
| Diabetes mellitus type 1 | contraindication | 46635009 | DOID:9744 |
| Bradycardia | contraindication | 48867003 | |
| Sinus bradycardia | contraindication | 49710005 | |
| Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
| Sympathectomy | contraindication | 57071006 | |
| Acute nephropathy | contraindication | 58574008 | |
| Hepatic failure | contraindication | 59927004 | |
| Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Hypercalcemia | contraindication | 66931009 | DOID:12678 |
| Hypochloremic alkalosis | contraindication | 70134007 | |
| Decreased respiratory function | contraindication | 80954004 | |
| Oliguria | contraindication | 83128009 | |
| Hyponatremia | contraindication | 89627008 | |
| Gout | contraindication | 90560007 | DOID:13189 |
| Magnetic resonance imaging | contraindication | 113091000 | |
| Perioperative care | contraindication | 133897009 | |
| Hypomagnesemia | contraindication | 190855004 | |
| Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
| Atrioventricular block | contraindication | 233917008 | DOID:0050820 |
| Labor pain | contraindication | 247412007 | |
| Raynaud's phenomenon | contraindication | 266261006 | |
| Syncope | contraindication | 271594007 | |
| Surgical procedure | contraindication | 387713003 | |
| Chronic myocardial ischemia | contraindication | 413844008 | DOID:3393 |
| Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
| Inflammatory dermatosis | contraindication | 703938007 | |
| Vagal Reflex Bradycardia | contraindication | ||
| Severe Cardiopulmonary Disease | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.5 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Alpha-2B adrenergic receptor | GPCR | AGONIST | Ki | 7.50 | CHEMBL | CHEMBL | |||
| Alpha-2C adrenergic receptor | GPCR | AGONIST | EC50 | 6.70 | WOMBAT-PK | CHEMBL | |||
| Alpha-2A adrenergic receptor | GPCR | AGONIST | Ki | 8.42 | CHEMBL | CHEMBL | |||
| Alpha-1D adrenergic receptor | GPCR | Ki | 6.22 | CHEMBL | |||||
| Alpha-1B adrenergic receptor | GPCR | Ki | 6.50 | PDSP | |||||
| Nischarin | Membrane receptor | Ki | 8.05 | CHEMBL | |||||
| Solute carrier family 22 member 1 | Transporter | IC50 | 4.65 | CHEMBL | |||||
| Solute carrier family 22 member 2 | Transporter | IC50 | 4.80 | WOMBAT-PK | |||||
| Multidrug and toxin extrusion protein 1 | Transporter | IC50 | 4.48 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 1A | GPCR | Ki | 5.49 | CHEMBL | |||||
| Alpha-1A adrenergic receptor | GPCR | Ki | 6.50 | PDSP | |||||
| Alpha-1B adrenergic receptor | GPCR | Ki | 5.99 | DRUG MATRIX | |||||
| Alpha-1A adrenergic receptor | GPCR | Kd | 6.59 | CHEMBL | |||||
| Alpha-2B adrenergic receptor | GPCR | Ki | 8.08 | CHEMBL | |||||
| Alpha-1D adrenergic receptor | GPCR | AGONIST | Ki | 6.90 | IUPHAR | ||||
| 5-hydroxytryptamine receptor 1A | GPCR | IC50 | 5.27 | CHEMBL | |||||
| Alpha-2A adrenergic receptor | GPCR | Ki | 9.41 | CHEMBL | |||||
| Alpha-1A adrenergic receptor | GPCR | EC50 | 7.05 | CHEMBL | |||||
| Alpha-2A adrenergic receptor | GPCR | IC50 | 8.70 | CHEMBL | |||||
| Beta-1 adrenergic receptor | GPCR | Kd | 4.40 | CHEMBL | |||||
| Nischarin | Unclassified | Ki | 6.95 | CHEMBL | |||||
| Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Ion channel | BLOCKER | IC50 | 4.40 | IUPHAR | ||||
| Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Ion channel | BLOCKER | IC50 | 5.10 | IUPHAR | ||||
| Adrenergic receptor alpha-2 | GPCR | Ki | 8.82 | CHEMBL | |||||
| Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Ion channel | BLOCKER | IC50 | 5 | IUPHAR | ||||
| Alpha-1B adrenergic receptor | GPCR | EC50 | 7.08 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4017850 | VUID |
| N0000146207 | NUI |
| D00281 | KEGG_DRUG |
| 4205-91-8 | SECONDARY_CAS_RN |
| 142432 | RXNORM |
| 4017849 | VANDF |
| 4017850 | VANDF |
| C0009014 | UMLSCUI |
| CHEBI:46631 | CHEBI |
| CLU | PDB_CHEM_ID |
| CHEMBL134 | ChEMBL_ID |
| DB00575 | DRUGBANK_ID |
| CHEMBL1705 | ChEMBL_ID |
| D003000 | MESH_DESCRIPTOR_UI |
| 2803 | PUBCHEM_CID |
| 516 | IUPHAR_LIGAND_ID |
| 2624 | INN_ID |
| MN3L5RMN02 | UNII |
| 27687 | MMSL |
| 381 | MMSL |
| 4478 | MMSL |
| 4479 | MMSL |
| 89106 | MMSL |
| d00044 | MMSL |
| 000644 | NDDF |
| 004495 | NDDF |
| 372805007 | SNOMEDCT_US |
| 387121001 | SNOMEDCT_US |
| 62782004 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9723 | INJECTION, SOLUTION | 500 ug | INTRAVENOUS | ANDA | 21 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9723 | INJECTION, SOLUTION | 500 ug | INTRAVENOUS | ANDA | 21 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9724 | INJECTION, SOLUTION | 100 ug | INTRAVENOUS | ANDA | 21 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9724 | INJECTION, SOLUTION | 100 ug | INTRAVENOUS | ANDA | 21 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2127 | TABLET | 0.10 mg | ORAL | ANDA | 12 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2127 | TABLET | 0.10 mg | ORAL | ANDA | 12 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2128 | TABLET | 0.20 mg | ORAL | ANDA | 12 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2128 | TABLET | 0.20 mg | ORAL | ANDA | 12 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2129 | TABLET | 0.30 mg | ORAL | ANDA | 12 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2129 | TABLET | 0.30 mg | ORAL | ANDA | 12 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-4241 | TABLET, EXTENDED RELEASE | 0.10 mg | ORAL | ANDA | 19 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-4241 | TABLET, EXTENDED RELEASE | 0.10 mg | ORAL | ANDA | 19 sections |
| Clonidine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-4241 | TABLET, EXTENDED RELEASE | 0.10 mg | ORAL | ANDA | 19 sections |
| Clonidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0871 | PATCH | 0.10 mg | TRANSDERMAL | ANDA | 17 sections |
| Clonidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0871 | PATCH | 0.10 mg | TRANSDERMAL | ANDA | 17 sections |
| Clonidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0872 | PATCH | 0.20 mg | TRANSDERMAL | ANDA | 17 sections |
| Clonidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0872 | PATCH | 0.20 mg | TRANSDERMAL | ANDA | 17 sections |
| Clonidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0873 | PATCH | 0.30 mg | TRANSDERMAL | ANDA | 17 sections |
| Clonidine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0873 | PATCH | 0.30 mg | TRANSDERMAL | ANDA | 17 sections |
| Clonidine transdermal system | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3508 | PATCH | 0.10 mg | TRANSDERMAL | ANDA | 21 sections |
| Clonidine transdermal system | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3508 | PATCH | 0.10 mg | TRANSDERMAL | ANDA | 21 sections |
| Clonidine transdermal system | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3509 | PATCH | 0.20 mg | TRANSDERMAL | ANDA | 21 sections |
| Clonidine transdermal system | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3509 | PATCH | 0.20 mg | TRANSDERMAL | ANDA | 21 sections |
| Clonidine transdermal system | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3510 | PATCH | 0.30 mg | TRANSDERMAL | ANDA | 21 sections |
| Clonidine transdermal system | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3510 | PATCH | 0.30 mg | TRANSDERMAL | ANDA | 21 sections |
| Catapres-TTS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0031 | PATCH | 0.10 mg | TRANSDERMAL | NDA | 23 sections |
| Catapres-TTS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0031 | PATCH | 0.10 mg | TRANSDERMAL | NDA | 23 sections |
| Catapres-TTS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0032 | PATCH | 0.20 mg | TRANSDERMAL | NDA | 23 sections |
| Catapres-TTS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0032 | PATCH | 0.20 mg | TRANSDERMAL | NDA | 23 sections |
| Catapres-TTS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0033 | PATCH | 0.30 mg | TRANSDERMAL | NDA | 23 sections |